octinoxate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4236 5466-77-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • octyl methoxycinnamate
  • octinoxate
  • ethylhexyl methoxycinnamate
  • ethylhexyl p-methoxycinnamate
  • Parsol MOX
  • Eusolex 2292
  • parsol
  • methoxycinnamate
a UV filter compound
  • Molecular weight: 290.40
  • Formula: C18H26O3
  • CLOGP: 5.96
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 35.53
  • ALOGS: -5.81
  • ROTB: 10
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP2K6,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,STK33,TEK,TTK 38
kinase-selectivity-class AXL,BRAF,GRK2,MAPK7,PDK4,STK33 6
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Dec. 7, 1992 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 1160.95 24.97 326 8053 37644 90582424
Chronic sinusitis 457.29 24.97 143 8236 23659 90596409
Paraesthesia oral 413.31 24.97 142 8237 31517 90588551
Procedural pain 390.71 24.97 138 8241 33222 90586846
Vaginal flatulence 387.25 24.97 109 8270 12529 90607539
Female genital tract fistula 383.89 24.97 117 8262 17751 90602317
Radiculopathy 367.18 24.97 114 8265 18391 90601677
Proctitis 366.95 24.97 109 8270 15150 90604918
Vaginal discharge 340.81 24.97 109 8270 19355 90600713
Oral candidiasis 276.90 24.97 109 8270 35346 90584722
Haematochezia 230.35 24.97 118 8261 70795 90549273
Colitis ulcerative 227.33 24.97 111 8268 60155 90559913
Frequent bowel movements 227.23 24.97 109 8270 56826 90563242
Colitis 217.41 24.97 113 8266 69829 90550239
Rectal haemorrhage 210.48 24.97 117 8262 82627 90537441
Therapeutic product effect incomplete 202.77 24.97 157 8222 193739 90426329
Dyspepsia 163.92 24.97 140 8239 198020 90422048
Drug ineffective 150.02 24.97 366 8013 1383932 89236136
Weight decreased 108.11 24.97 153 8226 379757 90240311
Constipation 107.81 24.97 131 8248 280264 90339804
Squamous cell carcinoma of skin 107.20 24.97 36 8343 7413 90612655
Erythema 102.92 24.97 116 8263 229130 90390938
Anaemia 88.58 24.97 134 8245 352668 90267400
Infusion related reaction 79.77 24.97 140 8239 416640 90203428
Abdominal pain 74.51 24.97 132 8247 395589 90224479
Pyrexia 66.88 24.97 171 8208 660314 89959754
Carbuncle 65.64 24.97 17 8362 1419 90618649
Malaise 59.56 24.97 152 8227 585834 90034234
Monoclonal immunoglobulin present 59.05 24.97 17 8362 2107 90617961
Hypothalamo-pituitary disorder 58.07 24.97 17 8362 2235 90617833
Skin atrophy 57.56 24.97 21 8358 5508 90614560
Amyloid arthropathy 49.19 24.97 14 8365 1666 90618402
Asthma-chronic obstructive pulmonary disease overlap syndrome 48.75 24.97 18 8361 4881 90615187
Total lung capacity increased 48.32 24.97 18 8361 5003 90615065
Off label use 47.44 24.97 214 8165 1102038 89518030
Ochronosis 44.41 24.97 7 8372 42 90620026
Nasal polyps 43.84 24.97 21 8358 10859 90609209
Overweight 41.94 24.97 17 8362 5917 90614151
Fibrosis 41.89 24.97 17 8362 5935 90614133
Cholelithiasis 41.04 24.97 36 8343 52470 90567598
Neoplasm skin 40.56 24.97 14 8365 3128 90616940
Wrist deformity 40.14 24.97 14 8365 3224 90616844
Hypomania 38.38 24.97 18 8361 8879 90611189
Nausea 37.99 24.97 202 8177 1110114 89509954
Nephropathy 37.74 24.97 18 8361 9217 90610851
Jaundice cholestatic 36.31 24.97 18 8361 10025 90610043
Sarcoidosis 35.27 24.97 18 8361 10655 90609413
Bronchiectasis 34.54 24.97 23 8356 22307 90597761
Dyslipidaemia 33.27 24.97 17 8362 10090 90609978
Body height decreased 30.59 24.97 17 8362 11932 90608136
Pulmonary pain 30.56 24.97 13 8366 5101 90614967
Proctalgia 30.55 24.97 15 8364 8183 90611885
Joint swelling 30.48 24.97 5 8374 503295 90116773
Rhinitis allergic 30.17 24.97 19 8360 16766 90603302
Purpura 29.79 24.97 18 8361 14760 90605308
Schizophrenia 29.64 24.97 18 8361 14896 90605172
Bone density decreased 29.59 24.97 19 8360 17326 90602742
Renal cyst 29.32 24.97 17 8362 12933 90607135
Drug intolerance 28.12 24.97 4 8375 447587 90172481
Pain 26.65 24.97 170 8209 996171 89623897
Cardiac murmur 26.36 24.97 18 8361 18176 90601892
Swelling 25.73 24.97 4 8375 419054 90201014

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anal inflammation 165.17 26.04 34 1846 2195 42617260
SARS-CoV-2 test negative 154.75 26.04 31 1849 1744 42617711
Accident 128.95 26.04 34 1846 6469 42612986
Proctalgia 126.02 26.04 34 1846 7059 42612396
Haemorrhoids 92.73 26.04 33 1847 17064 42602391
Body temperature increased 90.75 26.04 34 1846 20324 42599131
Febrile neutropenia 49.11 26.04 50 1830 185653 42433802
Back pain 38.93 26.04 39 1841 141737 42477718
Chills 37.73 26.04 32 1848 94034 42525421
Pyrexia 34.77 26.04 62 1818 393980 42225475
Neutropenia 32.75 26.04 42 1838 199389 42420066
Pain 28.90 26.04 44 1836 244804 42374651
Vomiting 28.64 26.04 48 1832 289675 42329780

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 495.15 20.82 147 9560 21512 110558080
Chronic sinusitis 448.69 20.82 141 9566 24943 110554649
Paraesthesia oral 404.05 20.82 140 9567 33531 110546061
Female genital tract fistula 394.45 20.82 116 9591 16403 110563189
Vaginal flatulence 392.43 20.82 108 9599 12036 110567556
Procedural pain 381.34 20.82 136 9571 35429 110544163
Radiculopathy 363.76 20.82 113 9594 19223 110560369
Proctitis 356.98 20.82 108 9599 16819 110562773
Vaginal discharge 350.98 20.82 108 9599 17800 110561792
Oral candidiasis 254.38 20.82 108 9599 44652 110534940
Frequent bowel movements 212.01 20.82 110 9597 71280 110508312
Colitis ulcerative 203.69 20.82 110 9597 77253 110502339
Therapeutic product effect incomplete 194.14 20.82 159 9548 223646 110355946
Colitis 182.68 20.82 113 9594 102210 110477382
Haematochezia 182.34 20.82 118 9589 115406 110464186
Rectal haemorrhage 180.82 20.82 119 9588 119714 110459878
Dyspepsia 172.57 20.82 139 9568 190826 110388766
Anal inflammation 132.76 20.82 33 9674 2463 110577129
Proctalgia 131.94 20.82 48 9659 13174 110566418
SARS-CoV-2 test negative 122.25 20.82 30 9677 2123 110577469
Weight decreased 104.89 20.82 164 9543 467893 110111699
Constipation 96.79 20.82 137 9570 357649 110221943
Infusion related reaction 95.89 20.82 141 9566 381021 110198571
Erythema 94.64 20.82 122 9585 291325 110288267
Pyrexia 89.84 20.82 224 9483 898041 109681551
Malaise 86.31 20.82 185 9522 671634 109907958
Accident 84.70 20.82 33 9674 10919 110568673
Squamous cell carcinoma of skin 79.74 20.82 36 9671 17167 110562425
Carbuncle 66.15 20.82 17 9690 1450 110578142
Pain 61.12 20.82 203 9504 954752 109624840
Abdominal pain 60.91 20.82 137 9570 512852 110066740
Anaemia 60.44 20.82 142 9565 546944 110032648
Skin atrophy 58.73 20.82 22 9685 6542 110573050
Monoclonal immunoglobulin present 56.92 20.82 17 9690 2523 110577069
Hypothalamo-pituitary disorder 55.01 20.82 17 9690 2829 110576763
Total lung capacity increased 52.64 20.82 19 9688 5093 110574499
Amyloid arthropathy 49.90 20.82 14 9693 1666 110577926
Asthma-chronic obstructive pulmonary disease overlap syndrome 48.64 20.82 19 9688 6325 110573267
Haemorrhoids 45.55 20.82 32 9675 35640 110543952
Nasal polyps 43.95 20.82 22 9685 13178 110566414
Ochronosis 42.28 20.82 7 9700 63 110579529
Overweight 41.38 20.82 17 9690 6447 110573145
Wrist deformity 41.06 20.82 14 9693 3175 110576417
Neoplasm skin 41.00 20.82 14 9693 3190 110576402
Hypomania 39.94 20.82 19 9688 10191 110569401
Body temperature increased 39.37 20.82 35 9672 54678 110524914
Fibrosis 38.64 20.82 17 9690 7625 110571967
Cholelithiasis 36.82 20.82 36 9671 63386 110516206
Sarcoidosis 36.18 20.82 19 9688 12560 110567032
Nausea 35.10 20.82 206 9501 1235484 109344108
Rhinitis allergic 35.01 20.82 21 9686 17901 110561691
Jaundice cholestatic 33.52 20.82 19 9688 14589 110565003
Body height decreased 33.39 20.82 17 9690 10546 110569046
Drug interaction 32.94 20.82 3 9704 500180 110079412
Off label use 32.77 20.82 234 9473 1499951 109079641
Bone density decreased 31.87 20.82 19 9688 16023 110563569
Bronchiectasis 29.60 20.82 25 9682 36468 110543124
Nephropathy 29.52 20.82 17 9690 13450 110566142
Pulmonary pain 28.62 20.82 13 9694 6280 110573312
Dyslipidaemia 26.84 20.82 17 9690 15948 110563644
Dyspnoea 26.62 20.82 35 9672 1106837 109472755
Toxicity to various agents 26.59 20.82 5 9702 480550 110099042
Schizophrenia 26.52 20.82 19 9688 21807 110557785
Renal cyst 24.84 20.82 17 9690 18155 110561437
Cardiac murmur 24.47 20.82 19 9688 24609 110554983
Joint swelling 23.68 20.82 5 9702 442840 110136752
Therapeutic product effect delayed 22.76 20.82 10 9697 4469 110575123
Death 22.63 20.82 17 9690 698852 109880740
Limb injury 21.16 20.82 21 9686 37615 110541977

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D02BA02 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
PROTECTIVES AGAINST UV-RADIATION
Protectives against UV-radiation for topical use
MeSH PA D003879 Dermatologic Agents
MeSH PA D011837 Radiation-Protective Agents
MeSH PA D013473 Sunscreening Agents
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:35610 antineoplastic agent

Related Drugs by ATC class:

D02BA Protectives against UV-radiation for topical use 1 drug
aminobenzoic acid

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Discoloration of skin indication 3253007
Chloasma indication 36209000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4Y5P7MUD51 UNII
4025697 VUID
N0000179014 NUI
D05225 KEGG_DRUG
4020294 VANDF
4020377 VANDF
4020661 VANDF
4025697 VANDF
C0046100 UMLSCUI
CHEBI:134750 CHEBI
CHEMBL3183184 ChEMBL_ID
5355130 PUBCHEM_CID
DB09496 DRUGBANK_ID
7945 INN_ID
C118580 MESH_SUPPLEMENTAL_RECORD_UI
C516303 MESH_SUPPLEMENTAL_RECORD_UI
13369 RXNORM
003659 NDDF
007440 NDDF
255902000 SNOMEDCT_US
411144000 SNOMEDCT_US
83834-59-7 SECONDARY_CAS_RN

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen HUMAN OTC DRUG LABEL 3 0023-5494 LOTION 75 mg TOPICAL OTC Monograph Drug 13 sections
TOTAL DEFENSE REPAIR BROAD SPECTRUM SPF 34 Sunscreen (Tinted) HUMAN OTC DRUG LABEL 4 0023-5497 LOTION 75 mg TOPICAL OTC Monograph Drug 13 sections
Essential Defense Everyday Clear Broad Spectrum SPF 47 Sunscreen HUMAN OTC DRUG LABEL 2 0023-5738 LOTION 75 mg TOPICAL OTC Monograph Drug 13 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
Solbar Thirty SPF 30 HUMAN OTC DRUG LABEL 5 0096-0685 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
Solbar Avo SPF35 HUMAN OTC DRUG LABEL 4 0096-0687 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
Solbar Zinc SPF38 HUMAN OTC DRUG LABEL 3 0096-0688 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
SOLBAR THIRTY HUMAN OTC DRUG LABEL 5 0096-0689 GEL 75 mg TOPICAL OTC Monograph Drug 11 sections
SOLBAR SUNSCREEN 35 AVO HUMAN OTC DRUG LABEL 4 0096-0690 CREAM 75 mg TOPICAL OTC Monograph Drug 11 sections
SOLBAR SUNSCREEN 40 ZINC HUMAN OTC DRUG LABEL 3 0096-0691 CREAM 75 mg TOPICAL OTC Monograph Drug 11 sections
SOLBAR SUNSCREEN 50 FIFTY HUMAN OTC DRUG LABEL 4 0096-0693 CREAM 75 mg TOPICAL OTC Monograph Drug 10 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.08 g TOPICAL OTC Monograph Drug 11 sections
Daily Facial MoisturizerSPF 25 HUMAN OTC DRUG LABEL 4 0096-0721 CREAM 0.08 g TOPICAL OTC Monograph Drug 11 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
Solbar Fifty SPF50 HUMAN OTC DRUG LABEL 4 0096-0741 CREAM 0.08 g TOPICAL OTC Monograph Drug 8 sections
Cetaphil Daily Facial Moisturizer with suncreen SPF 50 HUMAN OTC DRUG LABEL 5 0299-4930 LOTION 75 mg TOPICAL OTC Monograph Drug 12 sections
Walgreens Anti-Sagging and Ultra Hydrating Day Cream Broad Spectrum SPF15 Sunscreen HUMAN OTC DRUG LABEL 3 0363-0696 CREAM 10 g TOPICAL OTC monograph not final 12 sections
Creal Zink Sunscreen SPF 50Well at Walgreens HUMAN OTC DRUG LABEL 3 0363-1117 STICK 7.50 g TOPICAL OTC monograph not final 7 sections
Walgreens SunscreenSPF 15 HUMAN OTC DRUG LABEL 2 0363-4001 LOTION 7.50 g TOPICAL OTC monograph not final 10 sections
Walgreens Dark Tanning Oil SunscreenSPF 4 HUMAN OTC DRUG LABEL 1 0363-4004 SPRAY 3 g TOPICAL OTC monograph not final 10 sections
Walgreens SunscreenSPF 45 SPF 45 SPF 45 HUMAN OTC DRUG LABEL 3 0363-4008 LOTION 7.50 g TOPICAL OTC monograph not final 10 sections
Chapstick Moisturizer Original HUMAN OTC DRUG LABEL 3 0573-0725 STICK 75 mg TOPICAL OTC Monograph Drug 14 sections
Chapstick Moisturizer Green Apple HUMAN OTC DRUG LABEL 3 0573-0728 STICK 75 mg TOPICAL OTC MONOGRAPH FINAL 14 sections
Chapstick Moisturizer Cool Mint HUMAN OTC DRUG LABEL 3 0573-0768 STICK 75 mg TOPICAL OTC Monograph Drug 14 sections
Artistry Ideal Radiance Illuminating CC SPF50 Broad Spectrum Sunscreen - Light HUMAN OTC DRUG LABEL 5 10056-030 CREAM 55 mg TOPICAL OTC Monograph Drug 11 sections
Beyond ColorPlumping Lipcolor HUMAN OTC DRUG LABEL 1 10096-0038 LIPSTICK 75 mg TOPICAL OTC monograph not final 13 sections
Skin So Soft Bug Guard Plus IR3535Cool N Fabulous Disappearing Color Insect Repellent Sunscreen HUMAN OTC DRUG LABEL 3 10096-0071 LOTION 75 mg TOPICAL OTC monograph not final 7 sections
moisture therapyintensive healing and repair lip HUMAN OTC DRUG LABEL 2 10096-0103 OINTMENT 75 mg TOPICAL OTC monograph not final 13 sections