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| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-infectives, sulfonamides | 4142 | 22199-08-2 |
| Molecule | Description |
|---|---|
|
Synonyms:
|
Antibacterial used topically in burn therapy.
|
None
None
None
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 26, 1973 | FDA | KING PHARMS |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug hypersensitivity | 222.13 | 17.22 | 160 | 3090 | 463449 | 90161748 |
| PRIDE syndrome | 30.51 | 17.22 | 4 | 3246 | 16 | 90625181 |
| SJS-TEN overlap | 29.25 | 17.22 | 7 | 3243 | 1101 | 90624096 |
| Tumour necrosis factor receptor-associated periodic syndrome | 24.07 | 17.22 | 4 | 3246 | 96 | 90625101 |
| Cellulitis | 21.34 | 17.22 | 21 | 3229 | 91316 | 90533881 |
| Oral lichen planus | 20.89 | 17.22 | 5 | 3245 | 786 | 90624411 |
| Pyoderma gangrenosum | 19.61 | 17.22 | 7 | 3243 | 4457 | 90620740 |
| Oral fungal infection | 17.62 | 17.22 | 6 | 3244 | 3326 | 90621871 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug hypersensitivity | 90.52 | 23.63 | 55 | 1777 | 99334 | 42520169 |
| Toxic epidermal necrolysis | 89.47 | 23.63 | 36 | 1796 | 26714 | 42592789 |
| Skin graft failure | 34.53 | 23.63 | 6 | 1826 | 157 | 42619346 |
| Thermal burn | 25.29 | 23.63 | 8 | 1824 | 2946 | 42616557 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug hypersensitivity | 210.72 | 18.28 | 161 | 4265 | 453929 | 110130944 |
| Toxic epidermal necrolysis | 77.19 | 18.28 | 40 | 4386 | 56687 | 110528186 |
| Cellulitis | 34.12 | 18.28 | 33 | 4393 | 125983 | 110458890 |
| Skin graft failure | 32.39 | 18.28 | 6 | 4420 | 244 | 110584629 |
| PRIDE syndrome | 28.45 | 18.28 | 4 | 4422 | 26 | 110584847 |
| SJS-TEN overlap | 24.83 | 18.28 | 7 | 4419 | 1867 | 110583006 |
| Tumour necrosis factor receptor-associated periodic syndrome | 23.84 | 18.28 | 4 | 4422 | 91 | 110584782 |
| Skin ulcer | 23.80 | 18.28 | 20 | 4406 | 63625 | 110521248 |
| Skin infection | 22.62 | 18.28 | 13 | 4413 | 22496 | 110562377 |
| Oral lichen planus | 19.56 | 18.28 | 5 | 4421 | 922 | 110583951 |
None
| Source | Code | Description |
|---|---|---|
| ATC | D06BA01 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE CHEMOTHERAPEUTICS FOR TOPICAL USE Sulfonamides |
| ATC | D06BA51 | DERMATOLOGICALS ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE CHEMOTHERAPEUTICS FOR TOPICAL USE Sulfonamides |
| FDA CS | M0020790 | Sulfonamides |
| FDA EPC | N0000175503 | Sulfonamide Antibacterial |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000891 | Anti-Infective Agents, Local |
| CHEBI has role | CHEBI:33281 | antibiotics |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Skin ulcer | indication | 46742003 | |
| Burn Wound Infections | indication | ||
| Minor Bacterial Skin Infections | indication | ||
| Leukopenia | contraindication | 84828003 | DOID:615 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
| Superimposed infection | contraindication | 193198003 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Anemia | contraindication | 271737000 | DOID:2355 |
| Pregnancy, function | contraindication | 289908002 | |
| Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
| Porphyria | contraindication | 418470004 |
| Species | Use | Relation |
|---|---|---|
| Dogs | Otitis externa complicated by bacterial and fungal organisms | Indication |
| Product | Applicant | Ingredients |
|---|---|---|
| Baytril Otic | Elanco US Inc. | 2 |
None
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Aurora kinase A | Kinase | IC50 | 4.68 | CHEMBL | |||||
| Dihydropteroate synthase | Enzyme | INHIBITOR | CHEMBL | CHEMBL |
| ID | Source |
|---|---|
| 4018504 | VUID |
| N0000146826 | NUI |
| D00433 | KEGG_DRUG |
| 4018504 | VANDF |
| C0037134 | UMLSCUI |
| CHEMBL1382627 | ChEMBL_ID |
| 441244 | PUBCHEM_CID |
| DB05245 | DRUGBANK_ID |
| 224926 | RXNORM |
| 1640 | MMSL |
| 1649 | MMSL |
| 5463 | MMSL |
| 003135 | NDDF |
| 19630009 | SNOMEDCT_US |
| 387112002 | SNOMEDCT_US |
| D012837 | MESH_DESCRIPTOR_UI |
| CHEBI:9142 | CHEBI |
| W46JY43EJR | UNII |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0440-0124 | CREAM | 10 mg | TOPICAL | NDA | 17 sections |
| SSD | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-206 | CREAM | 10 g | TOPICAL | NDA | 14 sections |
| ThermazeneSilver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-182 | CREAM | 10 mg | TOPICAL | NDA | 11 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-589 | CREAM | 10 mg | TOPICAL | NDA | 16 sections |
| Silver Sulfadiazene | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42254-118 | CREAM | 10 g | TOPICAL | NDA | 16 sections |
| SSD Cream | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-210 | CREAM | 10 g | TOPICAL | NDA | 11 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 45865-642 | CREAM | 10 mg | TOPICAL | NDA | 17 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 49999-185 | CREAM | 10 g | TOPICAL | ANDA | 19 sections |
| SILVADENE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0230 | CREAM | 10 mg | TOPICAL | NDA | 19 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0607 | CREAM | 10 mg | TOPICAL | NDA | 17 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0717 | CREAM | 10 mg | TOPICAL | NDA | 17 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-0763 | CREAM | 10 mg | TOPICAL | NDA | 17 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-2152 | CREAM | 10 mg | TOPICAL | NDA | 17 sections |
| SSD | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-7447 | CREAM | 10 g | TOPICAL | NDA | 11 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50436-1240 | CREAM | 10 mg | TOPICAL | NDA | 17 sections |
| Silver Sulfadiazene | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50436-3099 | CREAM | 10 g | TOPICAL | NDA | 16 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52959-635 | CREAM | 10 g | TOPICAL | NDA | 14 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-9090 | CREAM | 10 mg | TOPICAL | NDA | 17 sections |
| SSD | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53002-9091 | CREAM | 10 g | TOPICAL | NDA | 11 sections |
| Thermazene | HUMAN PRESCRIPTION DRUG LABEL | 1 | 53097-101 | CREAM | 10 mg | TOPICAL | NDA | 17 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-0375 | CREAM | 10 mg | TOPICAL | NDA | 14 sections |
| SILVER SULFADIAZINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 59762-0131 | CREAM | 10 mg | TOPICAL | NDA AUTHORIZED GENERIC | 21 sections |
| SSD Cream | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60760-962 | CREAM | 10 g | TOPICAL | NDA | 10 sections |
| SILVADENE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61570-131 | CREAM | 10 mg | TOPICAL | NDA | 19 sections |
| SILVER SULFADIAZINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61919-206 | CREAM | 10 mg | TOPICAL | NDA | 12 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 61919-237 | CREAM | 10 g | TOPICAL | NDA | 11 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63187-023 | CREAM | 10 mg | TOPICAL | NDA | 17 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-8768 | CREAM | 10 mg | TOPICAL | NDA | 16 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-8769 | CREAM | 10 mg | TOPICAL | NDA | 16 sections |
| Silver Sulfadiazine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63629-8770 | CREAM | 10 mg | TOPICAL | NDA | 16 sections |