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telavancin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| vancomycin related compounds | 4116 | 372151-71-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
an anti-infective agent
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.11 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 0.20 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.07 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 6.70 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 11, 2009 | FDA | THERAVANCE BIOPHARMA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hypertensive heart disease | 83.93 | 63.22 | 14 | 302 | 4582 | 110584401 |
| Tubulointerstitial nephritis | 77.98 | 63.22 | 20 | 296 | 54264 | 110534719 |
| Acute kidney injury | 69.14 | 63.22 | 34 | 282 | 635396 | 109953587 |
| Klebsiella infection | 63.38 | 63.22 | 14 | 302 | 19995 | 110568988 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01XA03 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE OTHER ANTIBACTERIALS Glycopeptide antibacterials |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| FDA EXT | N0000191280 | Lipoglycopeptides |
| FDA EPC | N0000191281 | Lipoglycopeptide Antibacterial |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
Related Drugs by ATC class:
J01XA Glycopeptide antibacterials 4 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Bacterial pneumonia | indication | 53084003 | DOID:874 |
| Pneumonia due to Staphylococcus aureus | indication | 441658007 | |
| Complicated Skin and Skin Structure Streptococcus Agalactiae Infection | indication | ||
| Complicated Skin and Skin Structure Streptococcus Pyogenes Infection | indication | ||
| Complicated Skin and Skin Structure Infection | indication | ||
| Complicated Skin and Skin Structure Enterococcus Faecalis Infection | indication | ||
| Complicated Skin and Skin Structure Staphylococcus Aureus Infection | indication | ||
| Torsades de pointes | contraindication | 31722008 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Chronic heart failure | contraindication | 48447003 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Prolonged QT interval | contraindication | 111975006 | |
| Decompensated cardiac failure | contraindication | 195111005 | |
| Impaired renal function disorder | contraindication | 197663003 | |
| Pregnancy, function | contraindication | 289908002 | |
| Pseudomembranous enterocolitis | contraindication | 397683000 | |
| Congenital long QT syndrome | contraindication | 442917000 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 1.06 | acidic |
| pKa2 | 2.59 | acidic |
| pKa3 | 6.27 | acidic |
| pKa4 | 7.41 | acidic |
| pKa5 | 7.98 | acidic |
| pKa6 | 10.14 | acidic |
| pKa7 | 10.72 | acidic |
| pKa8 | 11.49 | acidic |
| pKa9 | 12.61 | acidic |
| pKa10 | 12.69 | acidic |
| pKa11 | 13.01 | acidic |
| pKa12 | 13.37 | acidic |
| pKa13 | 13.47 | acidic |
| pKa14 | 12.0 | Basic |
| pKa15 | 9.53 | Basic |
| pKa16 | 8.33 | Basic |
| pKa17 | 5.6 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4029465 | VUID |
| N0000180310 | NUI |
| D06057 | KEGG_DRUG |
| 560130-42-9 | SECONDARY_CAS_RN |
| 4029465 | VANDF |
| 4029466 | VANDF |
| C1453642 | UMLSCUI |
| CHEBI:71229 | CHEBI |
| CHEMBL507870 | ChEMBL_ID |
| CHEMBL3301680 | ChEMBL_ID |
| DB06402 | DRUGBANK_ID |
| C487637 | MESH_SUPPLEMENTAL_RECORD_UI |
| 10925 | IUPHAR_LIGAND_ID |
| 8504 | INN_ID |
| XK134822Z0 | UNII |
| 3081362 | PUBCHEM_CID |
| 473837 | RXNORM |
| 167756 | MMSL |
| 26725 | MMSL |
| 30522 | MMSL |
| d07483 | MMSL |
| 013290 | NDDF |
| 013291 | NDDF |
| 443552009 | SNOMEDCT_US |
| 443553004 | SNOMEDCT_US |
| 768493001 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Vibativ | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52118-001 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 15 mg | INTRAVENOUS | NDA | 33 sections |
| Vibativ | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52118-002 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 15 mg | INTRAVENOUS | NDA | 33 sections |
| VIBATIV | HUMAN PRESCRIPTION DRUG LABEL | 1 | 66220-315 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 15 mg | INTRAVENOUS | NDA | 30 sections |