sucralfate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4106 54182-58-0

Description:

MoleculeDescription

Synonyms:

  • sucralfate
  • antepsin
  • carafate
  • sucralfin
  • sucrate
  • sulcrate
  • ulcerlmin
  • ulcogant
A basic aluminum complex of sulfated sucrose.
  • Molecular weight:
  • Formula: None
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
4 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Oct. 30, 1981 FDA FOREST LABS INC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Vaginal flatulence 253.28 11.86 117 36964 12521 90578845
Proctitis 244.10 11.86 121 36960 15138 90576228
Female genital tract fistula 234.53 11.86 124 36957 17744 90573622
Radiculopathy 224.87 11.86 122 36959 18383 90572983
Vaginal discharge 213.64 11.86 120 36961 19344 90572022
Chronic sinusitis 193.79 11.86 121 36960 23681 90567685
Oral candidiasis 167.58 11.86 129 36952 35326 90556040
Colitis 160.01 11.86 169 36912 69773 90521593
Haematochezia 135.63 11.86 156 36925 70757 90520609
Frequent bowel movements 130.98 11.86 138 36943 56797 90534569
Colitis ulcerative 126.22 11.86 139 36942 60127 90531239
Paraesthesia oral 123.62 11.86 103 36978 31556 90559810
Macular degeneration 120.96 11.86 110 36971 37860 90553506
Constipation 120.47 11.86 317 36764 280078 90311288
Abdominal pain 114.58 11.86 389 36692 395332 90196034
Rectal haemorrhage 108.81 11.86 151 36930 82593 90508773
Hand deformity 107.35 11.86 3 37078 296359 90295007
Maternal exposure during pregnancy 105.48 11.86 12 37069 360051 90231315
Procedural pain 105.00 11.86 96 36985 33264 90558102
Contraindicated product administered 95.46 11.86 10 37071 320129 90271237
Glossodynia 93.55 11.86 11 37070 321768 90269598
Systemic lupus erythematosus 92.37 11.86 18 37063 361878 90229488
Pericarditis 90.20 11.86 5 37076 270146 90321220
Gastritis 88.62 11.86 97 36984 41656 90549710
Nausea 88.23 11.86 763 36318 1109553 89481813
Anaemia 85.20 11.86 327 36754 352475 90238891
Gastric ulcer 73.06 11.86 72 37009 27376 90563990
Weight decreased 72.78 11.86 328 36753 379582 90211784
Cholecystitis chronic 72.61 11.86 47 37034 9779 90581587
Joint swelling 72.23 11.86 60 37021 503240 90088126
Early satiety 66.11 11.86 24 37057 1383 90589983
Wound 65.82 11.86 21 37060 302959 90288407
Helicobacter infection 65.30 11.86 8 37073 226842 90364524
Oesophagitis 60.95 11.86 53 37028 17196 90574170
Exposure during pregnancy 58.44 11.86 13 37068 238397 90352969
Hepatic enzyme increased 56.85 11.86 39 37042 360697 90230669
General physical health deterioration 56.49 11.86 38 37043 355077 90236289
Treatment failure 56.25 11.86 27 37054 303901 90287465
Arthropathy 53.32 11.86 43 37038 366199 90225167
Angina bullosa haemorrhagica 52.81 11.86 12 37069 121 90591245
Musculoskeletal stiffness 52.39 11.86 28 37053 296504 90294862
Impaired gastric emptying 50.67 11.86 42 37039 12767 90578599
Drug intolerance 47.95 11.86 68 37013 447523 90143843
Impaired healing 47.81 11.86 18 37063 234181 90357185
Type 2 diabetes mellitus 46.10 11.86 13 37068 203231 90388135
Psoriatic arthropathy 45.86 11.86 18 37063 228317 90363049
Erythema 45.39 11.86 200 36881 229046 90362320
Lower respiratory tract infection 45.26 11.86 23 37058 250636 90340730
Product use issue 45.25 11.86 41 37040 329878 90261488
Dehydration 42.63 11.86 175 36906 194272 90397094
Gastrointestinal haemorrhage 40.68 11.86 104 36977 90144 90501222
Product dose omission issue 40.41 11.86 230 36851 291457 90299909
Rheumatoid arthritis 39.91 11.86 54 37027 362560 90228806
Alopecia 38.12 11.86 92 36989 494979 90096387
Peptic ulcer 37.56 11.86 25 37056 5450 90585916
Blister 37.02 11.86 30 37051 254968 90336398
Toxicity to various agents 36.88 11.86 38 37043 287808 90303558
Facial asymmetry 36.71 11.86 14 37067 926 90590440
Therapeutic product effect decreased 36.29 11.86 36 37045 277535 90313831
Discomfort 35.39 11.86 36 37045 274299 90317067
Muscle swelling 34.92 11.86 12 37069 588 90590778
Haematemesis 34.87 11.86 55 37026 33671 90557695
Irritable bowel syndrome 34.60 11.86 21 37060 207427 90383939
Reflux gastritis 34.51 11.86 15 37066 1389 90589977
Hypersensitivity 32.29 11.86 88 36993 454589 90136777
Dyspepsia 32.00 11.86 163 36918 197997 90393369
Swelling 31.36 11.86 79 37002 418979 90172387
Urinary tract infection 31.18 11.86 223 36858 305409 90285957
Cholelithiasis 30.72 11.86 67 37014 52439 90538927
Bursitis 30.64 11.86 8 37073 131646 90459720
Gastrooesophageal reflux disease 30.57 11.86 142 36939 166195 90425171
Ill-defined disorder 30.44 11.86 19 37062 184872 90406494
Mobility decreased 30.01 11.86 35 37046 250699 90340667
Headache 29.88 11.86 507 36574 862239 89729127
Facet joint syndrome 29.49 11.86 3 37078 98386 90492980
Gallbladder disorder 28.84 11.86 38 37043 19765 90571601
Cellulitis 28.29 11.86 92 36989 91245 90500121
Intentional overdose 27.76 11.86 3 37078 93831 90497535
Tarsal tunnel syndrome 27.70 11.86 10 37071 567 90590799
Grip strength decreased 27.29 11.86 3 37078 92573 90498793
Hiatus hernia 27.11 11.86 42 37039 25319 90566047
Fibromyalgia 26.67 11.86 27 37054 206242 90385124
Malaise 26.29 11.86 360 36721 585626 90005740
Drug ineffective 26.25 11.86 404 36677 1383894 89207472
Wheezing 25.63 11.86 36 37045 238044 90353322
Diarrhoea 25.63 11.86 532 36549 938658 89652708
Vulval disorder 25.55 11.86 12 37069 1332 90590034
Faeces discoloured 25.20 11.86 37 37044 21283 90570083
Oesophageal ulcer 25.00 11.86 19 37062 5100 90586266
Haemoglobin decreased 24.60 11.86 131 36950 161825 90429541
C-reactive protein increased 24.31 11.86 23 37058 181366 90410000
Wound infection 23.76 11.86 7 37074 106395 90484971
Hypercholesterolaemia 23.73 11.86 6 37075 100886 90490480
Back pain 23.41 11.86 215 36866 316960 90274406
Gait inability 22.82 11.86 16 37065 146440 90444926
Genotype drug resistance test positive 22.38 11.86 8 37073 441 90590925
Paranoia 22.34 11.86 27 37054 12881 90578485
Vascular rupture 22.02 11.86 12 37069 1821 90589545
External ear cellulitis 21.64 11.86 7 37074 284 90591082
Bronchitis 21.42 11.86 121 36960 152806 90438560
Liver injury 21.29 11.86 23 37058 170544 90420822
Red blood cell sedimentation rate increased 21.27 11.86 4 37077 82591 90508775
Blood alkaline phosphatase increased 21.24 11.86 55 37026 48024 90543342
Hip arthroplasty 21.17 11.86 3 37078 76205 90515161
Confusional state 21.01 11.86 84 36997 386121 90205245
Blood cholesterol increased 20.88 11.86 33 37048 207979 90383387
Rash 20.75 11.86 217 36864 795883 89795483
Oesophageal stenosis 20.43 11.86 15 37066 3821 90587545
Purpura senile 19.93 11.86 8 37073 607 90590759
Tendon injury 19.72 11.86 12 37069 2241 90589125
Dysphagia 19.27 11.86 94 36987 112184 90479182
Movement disorder 19.27 11.86 39 37042 28980 90562386
Overdose 18.88 11.86 22 37059 157687 90433679
Stomatitis 18.86 11.86 54 37027 274644 90316722
Urticaria 18.31 11.86 66 37015 312668 90278698
Vitamin B1 deficiency 18.23 11.86 7 37074 472 90590894
Blood magnesium decreased 18.21 11.86 27 37054 15666 90575700
Biliary dyskinesia 18.15 11.86 12 37069 2587 90588779
Burning sensation 17.95 11.86 62 37019 63390 90527976
Pancreatitis 17.85 11.86 66 37015 69760 90521606
Gastric polyps 17.82 11.86 15 37066 4657 90586709
Pulmonary fibrosis 17.75 11.86 11 37070 107492 90483874
Blood pressure diastolic increased 17.62 11.86 24 37057 12882 90578484
Drug abuse 17.35 11.86 6 37075 82341 90509025
Gastrointestinal ulcer 17.29 11.86 12 37069 2799 90588567
Liver abscess 17.12 11.86 13 37068 3483 90587883
Limb injury 17.07 11.86 39 37042 31469 90559897
Cough 17.05 11.86 228 36853 368734 90222632
Gallbladder injury 16.95 11.86 9 37072 1297 90590069
Upper gastrointestinal haemorrhage 16.61 11.86 32 37049 22944 90568422
Illness 16.57 11.86 72 37009 81897 90509469
Hallucination, auditory 16.44 11.86 26 37055 15949 90575417
Feeling abnormal 16.44 11.86 121 36960 167114 90424252
Keratomileusis 16.00 11.86 5 37076 181 90591185
Flatulence 15.94 11.86 45 37036 41322 90550044
Odynophagia 15.79 11.86 19 37062 9024 90582342
Epilepsy 15.66 11.86 7 37074 82199 90509167
Economic problem 15.63 11.86 12 37069 3269 90588097
Vestibular disorder 15.51 11.86 9 37072 1540 90589826
Upper respiratory tract infection 15.07 11.86 97 36984 128221 90463145
Inappropriate schedule of product administration 15.03 11.86 109 36972 149824 90441542
Prescribed underdose 14.91 11.86 6 37075 75013 90516353
Limb mass 14.86 11.86 12 37069 3516 90587850
Abdominal pain upper 14.72 11.86 204 36877 332470 90258896
Resorption bone increased 14.70 11.86 8 37073 1211 90590155
Inflammation 14.67 11.86 32 37049 178560 90412806
Vomiting 14.65 11.86 424 36657 787869 89803497
Intentional product use issue 14.62 11.86 43 37038 216849 90374517
Crepitations 14.49 11.86 18 37063 8834 90582532
Vocal cord operation 14.41 11.86 4 37077 95 90591271
Fear 14.35 11.86 25 37056 16597 90574769
Dysuria 14.35 11.86 42 37039 39359 90552007
Chronic obstructive pulmonary disease 14.27 11.86 64 37017 73765 90517601
Gastric haemorrhage 14.20 11.86 16 37065 7087 90584279
Adjustment disorder with depressed mood 14.09 11.86 3 37078 56750 90534616
Lung disorder 13.91 11.86 25 37056 149858 90441508
Musculoskeletal pain 13.81 11.86 31 37050 171220 90420146
Pharyngeal cyst 13.75 11.86 4 37077 113 90591253
Nasopharyngitis 13.64 11.86 104 36977 407000 90184366
Pyrexia 13.60 11.86 360 36721 660125 89931241
Obesity 13.42 11.86 14 37067 105493 90485873
Infusion site swelling 13.36 11.86 20 37061 11700 90579666
Suture insertion 13.34 11.86 5 37076 315 90591051
Cholecystectomy 13.32 11.86 20 37061 11735 90579631
Thiopurine methyltransferase decreased 13.30 11.86 5 37076 318 90591048
Hypersomnia 13.19 11.86 28 37053 21503 90569863
AST/ALT ratio abnormal 13.19 11.86 4 37077 131 90591235
Death 13.18 11.86 261 36820 456290 90135076
Knee arthroplasty 13.07 11.86 9 37072 83173 90508193
Nail disorder 12.98 11.86 4 37077 59063 90532303
Pancreatic enzyme abnormality 12.96 11.86 3 37078 33 90591333
Pain 12.72 11.86 513 36568 995828 89595538
Chills 12.69 11.86 95 36986 131886 90459480
Lip ulceration 12.58 11.86 9 37072 2203 90589163
Angiodysplasia 12.56 11.86 6 37075 692 90590674
Gastroenteritis 12.46 11.86 33 37048 29196 90562170
Abdominal discomfort 12.45 11.86 130 36951 477198 90114168
Sciatica 12.29 11.86 14 37067 101368 90489998
Pregnancy 12.27 11.86 5 37076 62042 90529324
Ocular neoplasm 12.21 11.86 5 37076 399 90590967
Haematocrit decreased 11.94 11.86 41 37040 41791 90549575
Intentional dose omission 11.92 11.86 24 37057 17759 90573607
Synovial cyst 11.92 11.86 19 37062 11733 90579633
Completed suicide 11.91 11.86 26 37055 145032 90446334

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gastrointestinal haemorrhage 61.24 12.02 120 15481 97606 42508128
Oesophagitis 42.44 12.02 39 15562 15208 42590526
Gastrooesophageal reflux disease 40.75 12.02 65 15536 44958 42560776
Enterococcus test positive 40.01 12.02 17 15584 1668 42604066
Blood aluminium increased 39.05 12.02 6 15595 3 42605731
Dysphagia 26.33 12.02 72 15529 72647 42533087
Oesophageal ulcer 24.64 12.02 16 15585 3743 42601991
Vomiting 24.19 12.02 185 15416 289538 42316196
Off label use 23.82 12.02 137 15464 638198 41967536
Brugada syndrome 22.95 12.02 10 15591 1043 42604691
Asthma-chronic obstructive pulmonary disease overlap syndrome 22.12 12.02 11 15590 1548 42604186
Nausea 21.67 12.02 231 15370 396568 42209166
Gastric mucosal calcinosis 20.74 12.02 3 15598 0 42605734
Pneumonia 20.43 12.02 240 15361 421909 42183825
Decreased appetite 20.00 12.02 130 15471 193007 42412727
Toxicity to various agents 19.25 12.02 34 15567 229102 42376632
Abdominal pain upper 19.05 12.02 70 15531 82539 42523195
Completed suicide 18.70 12.02 6 15595 96459 42509275
Hypogonadism 17.54 12.02 11 15590 2423 42603311
Ulcer haemorrhage 17.27 12.02 12 15589 3138 42602596
Mucosal erosion 17.01 12.02 8 15593 997 42604737
Dyspepsia 16.02 12.02 42 15559 41310 42564424
Fatigue 15.78 12.02 235 15366 435406 42170328
Blood immunoglobulin E increased 15.76 12.02 12 15589 3613 42602121
Discoloured vomit 15.75 12.02 7 15594 765 42604969
Drug ineffective 15.47 12.02 152 15449 630045 41975689
Gastric haemorrhage 15.19 12.02 19 15582 10496 42595238
Dehydration 15.01 12.02 96 15505 141671 42464063
Oesophageal dilatation 15.00 12.02 5 15596 250 42605484
Abdominal pain 14.96 12.02 120 15481 190351 42415383
Sputum increased 14.93 12.02 11 15590 3152 42602582
Haemoglobin decreased 14.83 12.02 91 15510 132380 42473354
Escherichia infection 13.99 12.02 19 15582 11377 42594357
Urine phosphorus increased 13.71 12.02 4 15597 128 42605606
Gastritis 13.30 12.02 28 15573 23919 42581815
Asthenia 13.26 12.02 159 15442 280634 42325100
Joint dislocation reduction 13.06 12.02 3 15598 36 42605698
Melaena 12.68 12.02 37 15564 38709 42567025
Bezoar 12.42 12.02 7 15594 1269 42604465
Muscle twitching 12.04 12.02 18 15583 11762 42593972
Haematemesis 12.03 12.02 31 15570 30168 42575566

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Vaginal flatulence 208.06 11.49 99 42456 12045 110534699
Proctitis 199.12 11.49 107 42448 16820 110529924
Female genital tract fistula 198.75 11.49 106 42449 16413 110530331
Chronic sinusitis 187.20 11.49 118 42437 24966 110521778
Vaginal discharge 182.56 11.49 103 42452 17805 110528939
Macular degeneration 179.69 11.49 109 42446 21550 110525194
Radiculopathy 175.21 11.49 103 42452 19233 110527511
Oral candidiasis 140.11 11.49 125 42430 44635 110502109
Paraesthesia oral 127.75 11.49 105 42450 33566 110513178
Colitis 124.14 11.49 174 42381 102149 110444595
Procedural pain 108.70 11.49 98 42457 35467 110511277
Abdominal pain 96.62 11.49 422 42133 512567 110034177
Constipation 95.72 11.49 329 42226 357457 110189287
Haematochezia 93.41 11.49 163 42392 115361 110431383
Frequent bowel movements 91.98 11.49 125 42430 71265 110475479
Nausea 85.69 11.49 786 41769 1234904 109311840
Colitis ulcerative 82.80 11.49 124 42431 77239 110469505
Oesophagitis 77.82 11.49 74 42481 28641 110518103
Gastrointestinal haemorrhage 77.20 11.49 186 42369 165332 110381412
Hand deformity 71.16 11.49 3 42552 218503 110328241
Maternal exposure during pregnancy 70.12 11.49 8 42547 254875 110291869
Gastritis 69.13 11.49 94 42461 53605 110493139
Rectal haemorrhage 67.35 11.49 145 42410 119688 110427056
Weight decreased 66.36 11.49 355 42200 467702 110079042
Pericarditis 65.26 11.49 5 42550 219109 110327635
Systemic lupus erythematosus 65.15 11.49 10 42545 254328 110292416
Contraindicated product administered 63.05 11.49 10 42545 248257 110298487
Early satiety 59.77 11.49 24 42531 1939 110544805
Cholecystitis chronic 59.38 11.49 40 42515 9460 110537284
Anaemia 57.08 11.49 383 42172 546703 110000041
Folliculitis 52.35 11.49 3 42552 167650 110379094
Toxicity to various agents 52.13 11.49 65 42490 480490 110066254
Psoriatic arthropathy 52.10 11.49 7 42548 196754 110349990
Glossodynia 51.95 11.49 11 42544 221993 110324751
Gastric ulcer 51.69 11.49 70 42485 39757 110506987
Helicobacter infection 49.30 11.49 6 42549 181871 110364873
Dyspepsia 48.73 11.49 173 42382 190792 110355952
Gastrooesophageal reflux disease 45.02 11.49 162 42393 179814 110366930
Blood aluminium increased 43.71 11.49 7 42548 6 110546738
Drug intolerance 43.02 11.49 56 42499 406456 110140288
Joint swelling 42.89 11.49 65 42490 442780 110103964
Oesophageal ulcer 41.51 11.49 30 42525 7934 110538810
Impaired gastric emptying 41.38 11.49 37 42518 13238 110533506
General physical health deterioration 40.63 11.49 63 42492 425232 110121512
Angina bullosa haemorrhagica 37.85 11.49 10 42545 209 110546535
Exposure during pregnancy 37.75 11.49 9 42546 167415 110379329
Wound 37.22 11.49 22 42533 234415 110312329
Dehydration 36.86 11.49 208 42347 279303 110267441
Haematemesis 36.08 11.49 74 42481 59034 110487710
Musculoskeletal stiffness 35.72 11.49 33 42522 279789 110266955
Type 2 diabetes mellitus 35.39 11.49 12 42543 177220 110369524
Reflux gastritis 34.48 11.49 15 42540 1481 110545263
Hepatic enzyme increased 34.15 11.49 44 42511 320848 110225896
Treatment failure 33.86 11.49 34 42521 277200 110269544
Overdose 31.74 11.49 26 42529 233768 110312976
Haemoglobin decreased 31.41 11.49 183 42372 248544 110298200
Dysphagia 30.85 11.49 129 42426 153471 110393273
Lower respiratory tract infection 30.63 11.49 29 42526 243077 110303667
Enterococcus test positive 30.40 11.49 17 42538 2887 110543857
Facial asymmetry 30.02 11.49 12 42543 958 110545786
Product dose omission issue 29.81 11.49 219 42336 321563 110225181
Therapeutic product effect decreased 29.79 11.49 30 42525 244286 110302458
Erythema 29.70 11.49 203 42352 291244 110255500
Completed suicide 29.29 11.49 30 42525 242351 110304393
Arthropathy 29.00 11.49 41 42514 287481 110259263
Product use issue 28.97 11.49 47 42508 311648 110235096
Intentional overdose 28.19 11.49 8 42547 132493 110414251
Peptic ulcer 27.31 11.49 23 42532 7596 110539148
Vomiting 27.00 11.49 496 42059 910179 109636565
Hypersensitivity 26.61 11.49 74 42481 403924 110142820
Bursitis 25.58 11.49 9 42546 129909 110416835
Impaired healing 25.33 11.49 23 42532 196694 110350050
Rheumatoid arthritis 25.28 11.49 48 42507 299565 110247179
Cholelithiasis 25.09 11.49 67 42488 63355 110483389
Vulval disorder 23.84 11.49 10 42545 903 110545841
Oesophageal stenosis 23.65 11.49 18 42537 5147 110541597
Blood alkaline phosphatase increased 23.24 11.49 70 42485 70865 110475879
C-reactive protein increased 23.05 11.49 30 42525 217889 110328855
Diarrhoea 22.68 11.49 586 41969 1138919 109407825
Drug abuse 22.54 11.49 21 42534 177390 110369354
Muscle swelling 22.18 11.49 10 42545 1075 110545669
Fibromyalgia 21.98 11.49 20 42535 170889 110375855
Tarsal tunnel syndrome 21.29 11.49 8 42547 541 110546203
Prescribed overdose 21.19 11.49 4 42551 87577 110459167
Hiatus hernia 21.07 11.49 38 42517 27568 110519176
Mobility decreased 20.95 11.49 37 42518 237385 110309359
Grip strength decreased 20.87 11.49 3 42552 80171 110466573
Drug ineffective 20.53 11.49 438 42117 1520102 109026642
Purpura senile 20.40 11.49 8 42547 607 110546137
Alopecia 20.35 11.49 72 42483 364681 110182063
Headache 20.31 11.49 463 42092 881914 109664830
Off label use 20.29 11.49 432 42123 1499753 109046991
Gallbladder disorder 20.09 11.49 32 42523 20997 110525747
Vitamin B1 deficiency 20.02 11.49 9 42546 961 110545783
Melaena 19.90 11.49 65 42490 68692 110478052
Upper gastrointestinal haemorrhage 19.89 11.49 53 42502 50043 110496701
Urticaria 19.82 11.49 60 42495 318797 110227947
Swelling 19.78 11.49 69 42486 350972 110195772
Urinary tract infection 19.68 11.49 202 42353 326080 110220664
Biliary dyskinesia 19.60 11.49 12 42543 2409 110544335
Malaise 19.55 11.49 365 42190 671454 109875290
Tendon injury 19.48 11.49 12 42543 2437 110544307
Bronchitis 19.47 11.49 115 42440 156917 110389827
Gastric haemorrhage 19.19 11.49 27 42528 15888 110530856
Irritable bowel syndrome 19.08 11.49 21 42534 164194 110382550
Hypogonadism 19.06 11.49 11 42544 1983 110544761
Lung disorder 18.82 11.49 25 42530 180022 110366722
Cholecystectomy 18.81 11.49 22 42533 10787 110535957
Cellulitis 18.77 11.49 97 42458 125919 110420825
Gastrointestinal pain 18.77 11.49 23 42532 11837 110534907
Confusional state 18.62 11.49 105 42450 468575 110078169
Brugada syndrome 18.56 11.49 10 42545 1578 110545166
Product use in unapproved indication 18.44 11.49 99 42456 447278 110099466
Feeding disorder 18.38 11.49 31 42524 21331 110525413
Blood potassium decreased 18.29 11.49 54 42501 54060 110492684
External ear cellulitis 18.19 11.49 6 42549 276 110546468
Red blood cell sedimentation rate increased 18.06 11.49 4 42551 78298 110468446
Back pain 17.54 11.49 219 42336 370777 110175967
Vascular rupture 17.16 11.49 10 42545 1836 110544908
Abdominal pain upper 16.90 11.49 207 42348 348904 110197840
Keratomileusis 16.84 11.49 5 42550 162 110546582
Discomfort 16.74 11.49 36 42519 214671 110332073
Faeces discoloured 16.73 11.49 39 42516 33909 110512835
Hypercholesterolaemia 16.71 11.49 7 42548 90830 110455914
Wheezing 16.61 11.49 47 42508 255183 110291561
Epilepsy 16.48 11.49 9 42546 100200 110446544
Gastric polyps 16.44 11.49 15 42540 5508 110541236
Condition aggravated 16.15 11.49 193 42362 734643 109812101
Gastric disorder 16.09 11.49 38 42517 33319 110513425
Pneumonia 16.01 11.49 446 42109 876268 109670476
Liver injury 15.61 11.49 21 42534 150392 110396352
Crepitations 15.53 11.49 20 42535 10815 110535929
Wound infection 15.38 11.49 9 42546 96456 110450288
Ill-defined disorder 15.18 11.49 23 42532 156830 110389914
Intentional product use issue 15.15 11.49 47 42508 247859 110298885
Paranoia 14.83 11.49 29 42526 22345 110524399
Vein disorder 14.82 11.49 15 42540 6255 110540489
Blister 14.70 11.49 42 42513 227334 110319410
Cough 14.53 11.49 254 42301 461387 110085357
Vocal cord operation 14.38 11.49 4 42551 102 110546642
Upper respiratory tract infection 14.28 11.49 93 42462 131235 110415509
Pharyngeal cyst 14.27 11.49 4 42551 105 110546639
Pain 14.27 11.49 474 42081 954481 109592263
Limb mass 14.27 11.49 12 42543 3957 110542787
Odynophagia 14.23 11.49 22 42533 14079 110532665
Genotype drug resistance test positive 14.09 11.49 8 42547 1398 110545346
Discoloured vomit 13.83 11.49 9 42546 2008 110544736
Inflammation 13.77 11.49 34 42521 193204 110353540
Hypophagia 13.68 11.49 48 42507 52578 110494166
Oesophageal dilatation 13.62 11.49 6 42549 611 110546133
Blood cholesterol increased 13.57 11.49 32 42523 184753 110361991
Gastrointestinal ulcer 13.53 11.49 12 42543 4248 110542496
Resorption bone increased 13.44 11.49 8 42547 1526 110545218
Thiopurine methyltransferase decreased 13.36 11.49 5 42550 334 110546410
Blood chloride decreased 13.34 11.49 17 42538 9098 110537646
Flatulence 13.08 11.49 47 42508 52102 110494642
Suture insertion 13.04 11.49 5 42550 357 110546387
AST/ALT ratio abnormal 12.93 11.49 4 42551 149 110546595
Lymphocytosis 12.89 11.49 13 42542 5398 110541346
Urine phosphorus increased 12.45 11.49 4 42551 169 110546575
Ocular neoplasm 12.38 11.49 5 42550 410 110546334
Short-bowel syndrome 12.30 11.49 6 42549 770 110545974
Burning sensation 12.26 11.49 56 42499 69156 110477588
Sputum increased 12.23 11.49 13 42542 5738 110541006
Drug-induced liver injury 12.22 11.49 17 42538 120050 110426694
Drug hypersensitivity 12.09 11.49 114 42441 453976 110092768
Haematocrit decreased 12.09 11.49 54 42501 66063 110480681
Gastric ulcer haemorrhage 11.98 11.49 17 42538 10077 110536667
Anaemia of chronic disease 11.98 11.49 10 42545 3262 110543482
Pancreatitis 11.91 11.49 69 42486 93464 110453280
Drug interaction 11.90 11.49 129 42426 500054 110046690
Synovial cyst 11.77 11.49 18 42537 11412 110535332
Pyrexia 11.71 11.49 439 42116 897826 109648918
Vestibular disorder 11.67 11.49 9 42546 2623 110544121
Gastroenteritis 11.51 11.49 37 42518 38763 110507981
Blood loss anaemia 11.51 11.49 23 42532 18002 110528742

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02BX02 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD)
FDA CS M0015420 Organometallic Compounds
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D005765 Gastrointestinal Agents
FDA EPC N0000175801 Aluminum Complex
CHEBI has role CHEBI:49201 anti-ulcer drug

Related Drugs by ATC class:

A02BX Other drugs for peptic ulcer and gastro-oesophageal reflux disease (GORD) 15 drugs
acetoxolonealginic acidbismuth subcitratebismuth subnitratecarbenoxolonegefarnateirsogladinemethiosulfonium chloridepirenzepineproglumiderebamipidesulglicotide show all 15 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Duodenal ulcer disease indication 51868009 DOID:1724
Maintenance of Healing Duodenal Ulcer indication
Gingivostomatitis off-label use 20607006
Peptic reflux disease off-label use 57643001
Stomatitis off-label use 61170000 DOID:9637
Gastroesophageal reflux disease off-label use 235595009 DOID:8534
Gastric ulcer off-label use 397825006 DOID:10808
NSAID-Induced Duodenal Ulcer off-label use
Sclerotherapy Induced Esophageal Ulcer off-label use
Stress-Related GI Mucosal Bleeding Prevention off-label use
Maintenance of Healing Gastric Ulcer off-label use
Prevention of Stress Ulcer off-label use
Sclerotherapy-Induced Mucositis off-label use
End stage renal disease contraindication 46177005 DOID:784
Hyperglycemia contraindication 80394007 DOID:4195
Aluminum intoxication contraindication 236546003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Pepsin A-5 Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018816 VUID
N0000147119 NUI
4018816 VANDF
C0038633 UMLSCUI
CHEBI:9313 CHEBI
CHEMBL6067980 ChEMBL_ID
D013392 MESH_DESCRIPTOR_UI
DB00364 DRUGBANK_ID
7055 IUPHAR_LIGAND_ID
2723 INN_ID
XX73205DH5 UNII
10156 RXNORM
1948 MMSL
476 MMSL
5518 MMSL
d00377 MMSL
001132 NDDF
387387008 SNOMEDCT_US
69967001 SNOMEDCT_US
121494085 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 0093-2210 TABLET 1 g ORAL ANDA 20 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 0121-0974 SUSPENSION 1 g ORAL ANDA 17 sections
sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 0378-9205 SUSPENSION 1 g ORAL ANDA 20 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-4517 TABLET 1 g ORAL ANDA 20 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 0615-8653 TABLET 1 g ORAL ANDA 12 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0791 SUSPENSION 1 g ORAL ANDA 19 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 0904-7470 SUSPENSION 1 g ORAL ANDA 17 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 13668-754 SUSPENSION 1 g ORAL ANDA 18 sections
SUCRALFATE HUMAN PRESCRIPTION DRUG LABEL 1 16590-523 TABLET 1 g ORAL ANDA 2 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 17856-0062 SUSPENSION 1 g ORAL ANDA 18 sections
Carafate HUMAN PRESCRIPTION DRUG LABEL 1 17856-0170 SUSPENSION 1 g ORAL NDA 19 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 17856-0306 SUSPENSION 1 g ORAL ANDA 17 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 29033-003 TABLET 1 g ORAL ANDA 18 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 42291-781 SUSPENSION 1 g ORAL ANDA 18 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 42291-936 TABLET 1 g ORAL ANDA 17 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 43353-061 TABLET 1 g ORAL NDA 18 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 48433-091 TABLET 1 g ORAL ANDA 20 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 48433-226 SUSPENSION 1 g ORAL ANDA 19 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-3019 TABLET 1 g ORAL ANDA 20 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-5287 TABLET 1 g ORAL NDA authorized generic 18 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 50090-6455 TABLET 1 g ORAL ANDA 18 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 50268-745 SUSPENSION 1 g ORAL ANDA 18 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 50742-386 SUSPENSION 1 g ORAL ANDA 18 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 51079-753 TABLET 1 g ORAL ANDA 20 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 51407-881 TABLET 1 g ORAL ANDA 18 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 51655-031 TABLET 1 g ORAL ANDA 20 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 51655-475 TABLET 1 g ORAL NDA authorized generic 18 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 52817-840 SUSPENSION 1 g ORAL ANDA 18 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 53002-4930 TABLET 1 g ORAL ANDA 20 sections
Sucralfate HUMAN PRESCRIPTION DRUG LABEL 1 53808-0593 TABLET 1 g ORAL NDA 18 sections