betacarotene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
arotinoid derivatives 345 7235-40-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betacarotene
  • provatene
  • beta-Carotene
  • beta carotene
A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).
  • Molecular weight: 536.89
  • Formula: C40H56
  • CLOGP: 12
  • LIPINSKI: 2
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS: -6.14
  • ROTB: 10
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 4.378 High 0.82
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.104 High 0.82
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0 10^-6 cm/s High 0.82
dh-clint Dog hepatocyte intrinsic clearance 9.141 uL/min/10^6 cells High 0.82
dppb Dog plasma protein binding (% unbound) 0.100 % High 0.82
fcs-ppb Fetal calf serum protein binding (% unbound) 0 % High 0.82
herg hERG pIC50 4.225 pIC50 High 0.82
hh-clint Human hepatocyte intrinsic clearance 7.129 uL/min/10^6 cells High 0.82
hlm-clint Human liver microsomal intrinsic clearance 10.023 uL/min/mg protein High 0.82
hppb Human plasma protein binding (% unbound) 0.180 % High 0.82
kinase-safety-class ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,EGFR,EIF2AK3,ERBB2,GRK2,ITK,JAK3,MAP3K7,MAPK10,MAPK7,PDK2,PDK4,PDPK1,PRKDC,STK33,TEK,TGFBR1 25
kinase-selectivity-class AXL,BRAF,CDK4,EIF2AK3,GRK2,MAP2K6,STK33,TEK,TTK 9
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.010 High 0.82
mh-clint Mouse hepatocyte intrinsic clearance 33.574 High 0.82
mppb Mouse plasma protein binding (% unbound) 0.080 High 0.82
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.002 High 0.82
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 0 % High 0.82
rh-clint Rat hepatocyte intrinsic clearance 5.572 uL/min/10^6 cells High 0.82
rh-fuinc Rat hepatocyte fraction unbound in incubation 0.010 % High 0.82
rppb Rat plasma protein binding (% unbound) 0.090 % High 0.82
solubility-dd Solubility at pH 7.4 in DMSO 0.339 uM High 0.82

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Systemic lupus erythematosus 113.71 11.76 15 41141 361881 90225410
Product dose omission issue 113.49 11.76 340 40816 291347 90295944
Glossodynia 106.90 11.76 11 41145 321768 90265523
Diarrhoea 105.75 11.76 758 40398 938432 89648859
Pericarditis 105.16 11.76 4 41152 270147 90317144
Product use in unapproved indication 103.12 11.76 15 41141 336221 90251070
Treatment failure 101.97 11.76 10 41146 303918 90283373
Maternal exposure during pregnancy 101.74 11.76 20 41136 360043 90227248
Off label use 94.97 11.76 227 40929 1102025 89485266
Infusion related reaction 93.81 11.76 36 41120 416744 90170547
Wound 91.78 11.76 14 41142 302966 90284325
Product use issue 87.76 11.76 21 41135 329898 90257393
Duodenal ulcer perforation 87.07 11.76 3 41153 221285 90366006
Helicobacter infection 86.14 11.76 4 41152 226846 90360445
Fall 83.30 11.76 435 40721 481375 90105916
Unevaluable event 82.88 11.76 113 41043 54735 90532556
Drug intolerance 82.03 11.76 51 41105 447540 90139751
Folliculitis 76.32 11.76 4 41152 204349 90382942
Device expulsion 73.87 11.76 92 41064 40794 90546497
Fatigue 66.44 11.76 807 40349 1153216 89434075
Type 2 diabetes mellitus 60.16 11.76 10 41146 203234 90384057
Full blood count decreased 58.82 11.76 70 41086 29619 90557672
Nausea 56.45 11.76 759 40397 1109557 89477734
Deep vein thrombosis 56.42 11.76 127 41029 91493 90495798
Liver injury 56.17 11.76 6 41150 170561 90416730
Feeling abnormal 55.81 11.76 185 40971 167050 90420241
Therapeutic product effect decreased 54.55 11.76 29 41127 277542 90309749
Lower respiratory tract infection 54.15 11.76 23 41133 250636 90336655
Device dislocation 53.95 11.76 69 41087 31413 90555878
Muscle spasms 53.93 11.76 242 40914 251641 90335650
Irritable bowel syndrome 53.59 11.76 14 41142 207434 90379857
Hepatic enzyme increased 52.30 11.76 52 41104 360684 90226607
Intentional product use issue 51.71 11.76 17 41139 216875 90370416
Neuropathy peripheral 51.61 11.76 158 40998 136812 90450479
Therapy cessation 50.57 11.76 72 41084 36289 90551002
C-reactive protein increased 49.29 11.76 11 41145 181378 90405913
Drug hypersensitivity 48.63 11.76 85 41071 463524 90123767
Arthropathy 47.36 11.76 58 41098 366184 90221107
Toxicity to various agents 47.13 11.76 37 41119 287809 90299482
Drug ineffective 46.63 11.76 404 40752 1383894 89203397
Haemoglobin decreased 45.26 11.76 169 40987 161787 90425504
General physical health deterioration 45.12 11.76 57 41099 355058 90232233
Dizziness 44.29 11.76 435 40721 588849 89998442
Constipation 44.17 11.76 247 40909 280148 90307143
Therapeutic product effect incomplete 43.15 11.76 17 41139 193879 90393412
Blister 41.46 11.76 33 41123 254965 90332326
Fibromyalgia 41.33 11.76 21 41135 206248 90381043
Plasma cell myeloma 40.25 11.76 69 41087 40759 90546532
Back pain 40.17 11.76 264 40892 316911 90270380
Impaired healing 39.74 11.76 29 41127 234170 90353121
Asthenia 39.59 11.76 393 40763 533358 90053933
Dehydration 38.04 11.76 182 40974 194265 90393026
Joint swelling 37.56 11.76 111 41045 503189 90084102
Flatulence 37.01 11.76 67 41089 41300 90545991
Discomfort 37.00 11.76 42 41114 274293 90312998
Pulmonary embolism 36.95 11.76 137 41019 130683 90456608
Urinary tract infection 36.66 11.76 251 40905 305381 90281910
Joint range of motion decreased 35.32 11.76 9 41147 135634 90451657
Pneumonia 35.11 11.76 443 40713 637616 89949675
Ill-defined disorder 33.91 11.76 21 41135 184870 90402421
Psoriasis 33.91 11.76 145 41011 147609 90439682
Prescribed overdose 33.28 11.76 3 41153 97622 90489669
Headache 32.90 11.76 562 40594 862184 89725107
Hypercholesterolaemia 32.09 11.76 4 41152 100888 90486403
Bursitis 31.94 11.76 10 41146 131644 90455647
Intentional overdose 31.67 11.76 3 41153 93831 90493460
Hot flush 29.66 11.76 76 41080 59412 90527879
Injection site pain 28.65 11.76 155 41001 173544 90413747
COVID-19 28.52 11.76 21 41135 168822 90418469
Rheumatoid arthritis 28.48 11.76 78 41078 362536 90224755
Injection site erythema 27.68 11.76 103 41053 98399 90488892
Exposure during pregnancy 27.51 11.76 41 41115 238369 90348922
Obesity 27.47 11.76 7 41149 105500 90481791
Pelvic pain 26.85 11.76 34 41122 15323 90571968
Injection site haemorrhage 26.79 11.76 47 41109 28271 90559020
Grip strength decreased 26.41 11.76 5 41151 92571 90494720
Tremor 26.16 11.76 138 41018 153035 90434256
Wound infection 25.95 11.76 8 41148 106394 90480897
Influenza like illness 25.82 11.76 88 41068 80523 90506768
Asthma 25.72 11.76 44 41112 242116 90345175
White blood cell count decreased 25.48 11.76 146 41010 166963 90420328
Alopecia 25.41 11.76 127 41029 494944 90092347
Peripheral venous disease 25.11 11.76 4 41152 83917 90503374
Laboratory test abnormal 24.63 11.76 57 41099 41797 90545494
Wheezing 24.61 11.76 44 41112 238036 90349255
Dyspnoea 24.13 11.76 546 40610 880409 89706882
Hip fracture 23.97 11.76 49 41107 33028 90554263
Blood potassium decreased 23.81 11.76 61 41095 47666 90539625
Mobility decreased 23.60 11.76 49 41107 250685 90336606
Thrombosis 23.49 11.76 80 41076 73171 90514120
Atrial fibrillation 23.24 11.76 121 41035 133490 90453801
Gastrointestinal disorder 22.64 11.76 52 41104 256635 90330656
Epilepsy 22.29 11.76 5 41151 82201 90505090
Hypervolaemia 21.96 11.76 47 41109 32710 90554581
Eye swelling 21.85 11.76 44 41112 29342 90557949
Nasal congestion 21.61 11.76 85 41071 83329 90503962
Skin discolouration 21.45 11.76 56 41100 44259 90543032
Hypersensitivity 21.45 11.76 120 41036 454557 90132734
Balance disorder 21.29 11.76 94 41062 96986 90490305
Cardiac failure congestive 21.22 11.76 95 41061 98599 90488692
Vaginal haemorrhage 21.11 11.76 45 41111 31226 90556065
Live birth 21.08 11.76 5 41151 79102 90508189
Infection 20.87 11.76 89 41067 362005 90225286
Hypoxia 20.58 11.76 76 41080 72323 90514968
Pulmonary arterial hypertension 20.42 11.76 40 41116 26147 90561144
Sleep disorder 20.10 11.76 37 41119 197993 90389298
Platelet count decreased 19.80 11.76 118 41038 136851 90450440
Oedema peripheral 19.60 11.76 191 40965 257724 90329567
Blood cholesterol increased 19.28 11.76 41 41115 207971 90379320
Dysgeusia 19.19 11.76 60 41096 52500 90534791
Pleural effusion 19.18 11.76 101 41055 111890 90475401
Skin cancer 19.14 11.76 27 41129 13492 90573799
Lung disorder 19.07 11.76 24 41132 149859 90437432
Bladder disorder 19.07 11.76 24 41132 10748 90576543
Pulmonary hypertension 18.83 11.76 52 41104 42471 90544820
Red blood cell sedimentation rate increased 18.77 11.76 7 41149 82588 90504703
Multiple sclerosis relapse 18.45 11.76 59 41097 52246 90535045
Fluid retention 18.34 11.76 84 41072 88007 90499284
Autoimmune disorder 18.31 11.76 6 41150 76738 90510553
Overdose 18.30 11.76 27 41129 157682 90429609
Dyspnoea exertional 18.19 11.76 73 41083 72215 90515076
Adverse event 18.08 11.76 16 41140 117402 90469889
Chills 18.00 11.76 112 41044 131869 90455422
Vision blurred 17.89 11.76 98 41058 110195 90477096
Suicide attempt 17.80 11.76 6 41150 75393 90511898
Product complaint 17.70 11.76 26 41130 13474 90573817
Abdominal discomfort 17.45 11.76 136 41020 477192 90110099
Dry skin 16.89 11.76 82 41074 87991 90499300
Tooth disorder 16.84 11.76 41 41115 31049 90556242
Nocturia 16.82 11.76 22 41134 10233 90577058
Stomatitis 16.77 11.76 66 41090 274632 90312659
Flushing 16.69 11.76 82 41074 88409 90498882
Hypertension 16.42 11.76 131 41025 457401 90129890
Pulmonary fibrosis 16.13 11.76 15 41141 107488 90479803
Red blood cell count decreased 16.09 11.76 52 41104 46299 90540992
Condition aggravated 16.06 11.76 183 40973 595362 89991929
Bone pain 15.92 11.76 63 41093 61920 90525371
Anaemia 15.69 11.76 236 40920 352566 90234725
Body height decreased 15.65 11.76 23 41133 11926 90575365
Swelling 15.50 11.76 119 41037 418939 90168352
Myalgia 15.48 11.76 134 41022 174991 90412300
International normalised ratio increased 15.46 11.76 52 41104 47264 90540027
Illness 15.46 11.76 9 41147 81960 90505331
Injection site mass 15.16 11.76 32 41124 22058 90565233
Gallbladder disorder 15.14 11.76 30 41126 19773 90567518
Administration site swelling 14.92 11.76 9 41147 1490 90585801
Cellulitis 14.71 11.76 81 41075 91256 90496035
Hospice care 14.66 11.76 20 41136 9684 90577607
Weight decreased 14.59 11.76 248 40908 379662 90207629
Injection site bruising 14.11 11.76 54 41102 52253 90535038
Drug interaction 14.11 11.76 71 41085 276382 90310909
Abdominal pain 14.01 11.76 255 40901 395466 90191825
Plasma cell myeloma recurrent 13.79 11.76 13 41143 4215 90583076
Swelling face 13.68 11.76 73 41083 81279 90506012
Intestinal dilatation 13.60 11.76 10 41146 2300 90584991
Colostomy 13.35 11.76 8 41148 1309 90585982
Cardiac pacemaker insertion 13.33 11.76 13 41143 4394 90582897
Pollakiuria 13.29 11.76 39 41117 32966 90554325
Heavy menstrual bleeding 13.24 11.76 29 41127 20501 90566790
Night sweats 13.12 11.76 24 41132 128742 90458549
Hypophagia 13.10 11.76 41 41115 35896 90551395
Drug-induced liver injury 13.09 11.76 13 41143 90305 90496986
Lethargy 12.99 11.76 60 41096 63079 90524212
Depression 12.94 11.76 200 40956 300401 90286890
Multiple allergies 12.88 11.76 24 41132 15122 90572169
Blood calcium increased 12.71 11.76 21 41135 12037 90575254
Restless legs syndrome 12.56 11.76 30 41126 22440 90564851
Upper limb fracture 12.27 11.76 29 41127 21549 90565742
Gout 12.24 11.76 25 41131 16834 90570457
Burning sensation 12.11 11.76 59 41097 63393 90523898
Blepharospasm 12.10 11.76 5 41151 55440 90531851
Urinary incontinence 12.02 11.76 41 41115 37525 90549766
Complication associated with device 12.01 11.76 27 41129 19422 90567869
Aspartate aminotransferase increased 12.00 11.76 84 41072 102853 90484438
Haematocrit decreased 11.96 11.76 44 41112 41788 90545503
Pain in extremity 11.89 11.76 278 40878 450251 90137040
Nail disorder 11.84 11.76 6 41150 59061 90528230
Cough 11.77 11.76 234 40922 368728 90218563

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 143.69 13.06 98 28876 13358 42579003
Appendicitis 110.66 13.06 100 28874 20513 42571848
Hyperphosphataemia 102.95 13.06 79 28895 12925 42579436
Myasthenia gravis 102.16 13.06 86 28888 16051 42576310
Blood phosphorus increased 101.15 13.06 77 28897 12448 42579913
Analgesic therapy 90.49 13.06 56 28918 6468 42585893
Ventricular fibrillation 87.24 13.06 105 28869 30018 42562343
Drug therapy 84.04 13.06 53 28921 6327 42586034
Stress 83.37 13.06 125 28849 44087 42548274
Sleep disorder therapy 82.72 13.06 54 28920 6840 42585521
Anticoagulant therapy 78.75 13.06 45 28929 4490 42587871
Dry mouth 78.42 13.06 115 28859 39764 42552597
Antacid therapy 77.10 13.06 45 28929 4672 42587689
Hypophosphataemia 74.13 13.06 81 28893 20864 42571497
Thrombosis 73.38 13.06 151 28823 68360 42524001
Cardiogenic shock 73.32 13.06 105 28869 35535 42556826
Neuralgia 71.98 13.06 88 28886 25559 42566802
Off label use 70.22 13.06 213 28761 638122 41954239
Bacterial infection 69.25 13.06 90 28884 27789 42564572
Blood uric acid increased 67.36 13.06 67 28907 15480 42576881
Incorrect route of product administration 64.36 13.06 81 28893 24224 42568137
Abdominal distension 64.13 13.06 147 28827 71588 42520773
Constipation 62.72 13.06 247 28727 162044 42430317
Drug interaction 57.60 13.06 58 28916 266941 42325420
Activated partial thromboplastin time prolonged 57.14 13.06 62 28912 15841 42576520
Ascites 56.12 13.06 121 28853 56557 42535804
Blood cholesterol increased 55.31 13.06 79 28895 26662 42565699
Bronchopulmonary aspergillosis allergic 55.12 13.06 36 28938 4562 42587799
Hyponatraemia 53.41 13.06 171 28803 101291 42491070
Swelling 53.00 13.06 116 28858 54769 42537592
Blood calcium increased 51.34 13.06 44 28930 8410 42583951
Iron deficiency 50.39 13.06 49 28925 11012 42581349
End stage renal disease 50.04 13.06 59 28915 16499 42575862
Troponin increased 49.63 13.06 63 28911 18999 42573362
Toxicity to various agents 49.14 13.06 50 28924 229086 42363275
Sleep disorder 47.97 13.06 103 28871 47992 42544369
Completed suicide 47.77 13.06 5 28969 96460 42495901
Blood test abnormal 47.57 13.06 51 28923 12855 42579506
Fatigue 46.60 13.06 476 28498 435165 42157196
Product dose omission issue 45.81 13.06 217 28757 154148 42438213
Hyperlipidaemia 45.14 13.06 64 28910 21452 42570909
Ulcer 43.85 13.06 55 28919 16386 42575975
Plasma cell myeloma 41.95 13.06 97 28877 47481 42544880
Gout 41.45 13.06 71 28903 27984 42564377
Congenital hiatus hernia 41.34 13.06 34 28940 6140 42586221
Abdominal pain 39.68 13.06 243 28731 190228 42402133
Chronic obstructive pulmonary disease 39.42 13.06 113 28861 63001 42529360
Drug ineffective 38.56 13.06 261 28713 629936 41962425
COVID-19 37.38 13.06 16 28958 115932 42476429
Pleuritic pain 37.31 13.06 34 28940 7043 42585318
Aspiration 35.75 13.06 52 28922 17834 42574527
Asthenia 33.94 13.06 315 28659 280478 42311883
Micturition urgency 33.66 13.06 41 28933 11857 42580504
Full blood count decreased 32.99 13.06 54 28920 20506 42571855
Laboratory test abnormal 31.15 13.06 56 28918 22922 42569439
Bacteroides infection 30.39 13.06 20 28954 2567 42589794
Multiple organ dysfunction syndrome 29.92 13.06 138 28836 96897 42495464
Joint injury 29.82 13.06 43 28931 14633 42577728
Aortic stenosis 29.52 13.06 33 28941 8712 42583649
Febrile neutropenia 29.11 13.06 51 28923 185652 42406709
Sepsis 28.96 13.06 233 28741 199101 42393260
Diabetes mellitus 28.67 13.06 98 28876 59989 42532372
Breath sounds abnormal 28.41 13.06 38 28936 12055 42580306
Intentional product use issue 28.27 13.06 7 28967 71826 42520535
Total lung capacity decreased 26.75 13.06 21 28953 3549 42588812
Overdose 26.11 13.06 20 28954 105244 42487117
Transient ischaemic attack 25.68 13.06 65 28909 33674 42558687
Interstitial lung disease 25.00 13.06 11 28963 78451 42513910
Treatment failure 24.84 13.06 6 28968 62618 42529743
White blood cell count decreased 22.41 13.06 140 28834 110256 42482105
Product use in unapproved indication 21.99 13.06 59 28915 184397 42407964
Somnolence 21.60 13.06 167 28807 140938 42451423
Oedema peripheral 20.80 13.06 161 28813 135915 42456446
Adverse drug reaction 20.50 13.06 64 28910 37370 42554991
Cytokine release syndrome 20.35 13.06 3 28971 44524 42547837
Hepatic function abnormal 20.33 13.06 5 28969 51562 42540799
Upper respiratory tract infection 20.30 13.06 69 28905 42104 42550257
Drug intolerance 20.25 13.06 108 28866 80316 42512045
Cardiovascular disorder 19.97 13.06 34 28940 13331 42579030
Foetal exposure during pregnancy 19.84 13.06 4 28970 47307 42545054
Hypercholesterolaemia 19.61 13.06 33 28941 12816 42579545
Coma 19.60 13.06 6 28968 53548 42538813
Drug ineffective for unapproved indication 19.16 13.06 4 28970 46159 42546202
Acute kidney injury 19.08 13.06 159 28815 367178 42225183
Respiratory symptom 18.95 13.06 30 28944 11076 42581285
Pulmonary embolism 18.55 13.06 142 28832 119470 42472891
Nausea 18.15 13.06 374 28600 396425 42195936
Fall 18.13 13.06 241 28733 234279 42358082
Viral infection 17.82 13.06 44 28930 22439 42569922
Drug hypersensitivity 17.71 13.06 122 28852 99267 42493094
Leukopenia 17.53 13.06 15 28959 74731 42517630
Product use issue 17.29 13.06 16 28958 76735 42515626
Therapeutic product effect incomplete 16.93 13.06 14 28960 70925 42521436
Diarrhoea 16.60 13.06 420 28554 460429 42131932
Cardiac failure 16.14 13.06 30 28944 106826 42485535
Benign prostatic hyperplasia 15.44 13.06 40 28934 21012 42571349
Suicide attempt 15.43 13.06 6 28968 46094 42546267
Drug reaction with eosinophilia and systemic symptoms 14.89 13.06 5 28969 42070 42550291
Musculoskeletal stiffness 14.83 13.06 78 28896 57687 42534674
Psoriasis 14.14 13.06 68 28906 48536 42543825
Renal impairment 14.09 13.06 34 28940 110194 42482167
Tremor 13.88 13.06 113 28861 96816 42495545
Intentional product misuse 13.50 13.06 80 28894 61820 42530541
Depressed level of consciousness 13.38 13.06 8 28966 47962 42544399

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 179.42 11.46 104 56669 14151 110518375
Appendicitis 128.76 11.46 111 56662 28353 110504173
Off label use 125.94 11.46 376 56397 1499809 109032717
Blood phosphorus increased 122.61 11.46 86 56687 16254 110516272
Hyperphosphataemia 122.41 11.46 86 56687 16295 110516231
Product dose omission issue 117.65 11.46 398 56375 321384 110211142
Myasthenia gravis 116.27 11.46 93 56680 21418 110511108
Analgesic therapy 115.88 11.46 62 56711 7222 110525304
Treatment failure 114.40 11.46 7 56766 277227 110255299
Sleep disorder therapy 108.87 11.46 60 56713 7411 110525115
Drug therapy 107.47 11.46 59 56714 7232 110525294
Completed suicide 100.36 11.46 6 56767 242375 110290151
Anticoagulant therapy 97.75 11.46 50 56723 5311 110527215
Antacid therapy 96.68 11.46 50 56723 5434 110527092
Ventricular fibrillation 95.66 11.46 112 56661 41201 110491325
Systemic lupus erythematosus 95.00 11.46 10 56763 254328 110278198
Toxicity to various agents 86.30 11.46 72 56701 480483 110052043
Infusion related reaction 86.22 11.46 44 56729 381118 110151408
Blood uric acid increased 83.56 11.46 77 56696 21452 110511074
Product use issue 83.36 11.46 28 56745 311667 110220859
Thrombosis 82.14 11.46 176 56597 108486 110424040
Neuralgia 78.43 11.46 110 56663 48368 110484158
Drug ineffective 75.60 11.46 465 56308 1520075 109012451
Product use in unapproved indication 75.54 11.46 71 56702 447306 110085220
Device expulsion 75.30 11.46 86 56687 30805 110501721
Bacterial infection 75.28 11.46 105 56668 45931 110486595
Hypophosphataemia 75.23 11.46 89 56684 33093 110499433
Helicobacter infection 73.80 11.46 5 56768 181872 110350654
Cardiogenic shock 72.58 11.46 116 56657 57222 110475304
Ascites 72.08 11.46 152 56621 92656 110439870
Duodenal ulcer perforation 71.77 11.46 5 56768 177695 110354831
Maternal exposure during pregnancy 71.54 11.46 21 56752 254862 110277664
Constipation 71.01 11.46 367 56406 357419 110175107
Glossodynia 70.70 11.46 14 56759 221990 110310536
Pulmonary embolism 69.45 11.46 255 56518 214219 110318307
Pericarditis 69.40 11.46 14 56759 219100 110313426
Fall 69.20 11.46 538 56235 602944 109929582
Activated partial thromboplastin time prolonged 68.05 11.46 70 56703 22298 110510228
Blood calcium increased 67.08 11.46 63 56710 17977 110514549
Abdominal distension 66.95 11.46 220 56553 174883 110357643
Intentional product use issue 66.75 11.46 22 56751 247884 110284642
Troponin increased 66.10 11.46 79 56694 29687 110502839
End stage renal disease 64.96 11.46 67 56706 21406 110511120
Folliculitis 64.14 11.46 6 56767 167647 110364879
Stress 63.43 11.46 156 56617 105192 110427334
Plasma cell myeloma 62.10 11.46 114 56659 62822 110469704
Gout 60.68 11.46 84 56689 36482 110496044
COVID-19 60.50 11.46 25 56748 245035 110287491
Iron deficiency 60.19 11.46 60 56713 18416 110514110
Drug interaction 59.90 11.46 103 56670 500080 110032446
Asthenia 57.07 11.46 572 56201 688427 109844099
Fatigue 55.69 11.46 904 55869 1215054 109317472
Therapeutic product effect incomplete 54.97 11.46 23 56750 223782 110308744
Irritable bowel syndrome 53.03 11.46 10 56763 164205 110368321
Nausea 53.02 11.46 909 55864 1234781 109297745
Diarrhoea 52.84 11.46 849 55924 1138656 109393870
Sepsis 52.43 11.46 317 56456 327029 110205497
Congenital hiatus hernia 51.81 11.46 35 56738 6224 110526302
C-reactive protein increased 51.00 11.46 24 56749 217895 110314631
Chronic obstructive pulmonary disease 50.88 11.46 147 56626 109011 110423515
Type 2 diabetes mellitus 50.84 11.46 14 56759 177218 110355308
Joint swelling 50.48 11.46 94 56679 442751 110089775
Wound 50.16 11.46 29 56744 234408 110298118
Deep vein thrombosis 50.13 11.46 172 56601 139715 110392811
Intentional overdose 50.01 11.46 5 56768 132496 110400030
Hepatic enzyme increased 49.51 11.46 55 56718 320837 110211689
Abdominal pain 49.47 11.46 440 56333 512549 110019977
Aortic stenosis 49.31 11.46 46 56727 13013 110519513
Bronchopulmonary aspergillosis allergic 48.91 11.46 38 56735 8388 110524138
Therapy cessation 46.48 11.46 83 56690 44774 110487752
Fibromyalgia 46.29 11.46 15 56758 170894 110361632
Liver injury 44.82 11.46 11 56762 150402 110382124
Hyperlipidaemia 44.65 11.46 72 56701 35776 110496750
Dizziness 44.26 11.46 550 56223 697643 109834883
Micturition urgency 44.09 11.46 52 56721 19268 110513258
Unevaluable event 43.67 11.46 95 56678 59132 110473394
Full blood count decreased 43.48 11.46 67 56706 32032 110500494
Dehydration 43.05 11.46 268 56505 279243 110253283
Haemoglobin decreased 41.82 11.46 244 56529 248483 110284043
Device dislocation 41.30 11.46 65 56708 31639 110500887
Hyponatraemia 38.87 11.46 217 56556 217436 110315090
Therapeutic product effect decreased 38.64 11.46 41 56732 244275 110288251
Arthropathy 38.38 11.46 55 56718 287467 110245059
Incorrect route of product administration 36.60 11.46 93 56680 63968 110468558
Blood test abnormal 36.45 11.46 58 56715 28496 110504030
Aspiration 36.23 11.46 60 56713 30473 110502053
Overdose 36.13 11.46 40 56733 233754 110298772
Bursitis 35.90 11.46 11 56762 129907 110402619
Feeling abnormal 35.54 11.46 185 56588 180526 110352000
Oedema peripheral 35.38 11.46 289 56484 328371 110204155
Mobility decreased 35.19 11.46 42 56731 237380 110295146
Rheumatoid arthritis 34.65 11.46 63 56710 299550 110232976
Blister 33.94 11.46 40 56733 227336 110305190
Bacteroides infection 33.33 11.46 20 56753 2899 110529627
Tremor 33.09 11.46 197 56576 202035 110330491
Ill-defined disorder 32.70 11.46 20 56753 156833 110375693
Transient ischaemic attack 32.59 11.46 89 56684 63893 110468633
Dyspnoea 32.57 11.46 770 56003 1106102 109426424
Joint range of motion decreased 32.45 11.46 11 56762 121821 110410705
Multiple organ dysfunction syndrome 32.42 11.46 159 56614 151551 110380975
Prescribed overdose 31.30 11.46 4 56769 87577 110444949
Pleuritic pain 31.27 11.46 40 56733 16100 110516426
Peripheral venous disease 29.68 11.46 4 56769 84113 110448413
Hypervolaemia 29.50 11.46 73 56700 49387 110483139
Pneumonia 29.24 11.46 621 56152 876093 109656433
Pleural effusion 28.99 11.46 173 56600 177536 110354990
Obesity 28.89 11.46 11 56762 113340 110419186
Total lung capacity decreased 28.69 11.46 26 56747 7088 110525438
Epilepsy 28.57 11.46 8 56765 100201 110432325
Ulcer 28.26 11.46 66 56707 43050 110489476
Grip strength decreased 27.85 11.46 4 56769 80170 110452356
Discomfort 27.74 11.46 42 56731 214665 110317861
Hospice care 27.52 11.46 33 56740 12440 110520086
Benign prostatic hyperplasia 27.46 11.46 40 56733 18194 110514332
Impaired healing 26.87 11.46 37 56736 196680 110335846
Illness 26.53 11.46 5 56768 82166 110450360
Muscle spasms 26.46 11.46 238 56535 277919 110254607
Fluid retention 26.30 11.46 107 56666 94200 110438326
Mental status changes 25.88 11.46 92 56681 76030 110456496
Cytokine release syndrome 25.64 11.46 3 56770 70303 110462223
Therapeutic response decreased 25.20 11.46 9 56764 96490 110436036
Suicide attempt 24.78 11.46 11 56762 103383 110429143
Cardiac failure congestive 24.63 11.46 147 56626 150853 110381673
Coma 24.61 11.46 15 56758 117854 110414672
Exposure during pregnancy 24.40 11.46 30 56743 167394 110365132
Hip fracture 24.35 11.46 55 56718 35096 110497430
Somnolence 24.08 11.46 246 56527 297203 110235323
Flatulence 24.07 11.46 70 56703 52079 110480447
Infection 23.98 11.46 100 56673 362100 110170426
Autoimmune disorder 23.38 11.46 3 56770 65480 110467046
Drug ineffective for unapproved indication 23.03 11.46 12 56761 102826 110429700
Live birth 22.93 11.46 4 56769 69480 110463046
Hypersensitivity 22.92 11.46 118 56655 403880 110128646
Influenza like illness 22.85 11.46 98 56675 88314 110444212
Respiratory symptom 22.82 11.46 33 56740 14912 110517614
Multiple sclerosis relapse 22.77 11.46 67 56706 50173 110482353
Pelvic pain 22.61 11.46 34 56739 15908 110516618
Aspartate aminotransferase increased 22.54 11.46 150 56623 159786 110372740
Headache 21.82 11.46 600 56173 881777 109650749
Anaemia 21.72 11.46 398 56375 546688 109985838
Haematocrit decreased 21.70 11.46 79 56694 66038 110466488
Stomatitis 21.58 11.46 69 56704 270173 110262353
Alopecia 21.57 11.46 105 56668 364648 110167878
Drug-induced liver injury 21.50 11.46 18 56755 120049 110412477
Dyspnoea exertional 21.47 11.46 108 56665 103952 110428574
Hypoxia 21.07 11.46 126 56647 129389 110403137
Blood potassium decreased 20.67 11.46 68 56705 54046 110478480
White blood cell count decreased 20.66 11.46 194 56579 229196 110303330
Hepatic function abnormal 20.63 11.46 10 56763 89285 110443241
Wound infection 20.52 11.46 12 56761 96453 110436073
Wheezing 20.50 11.46 65 56708 255165 110277361
Viral infection 20.50 11.46 67 56706 53072 110479454
Pulmonary arterial hypertension 20.42 11.46 49 56724 32519 110500007
Diabetes mellitus 20.40 11.46 103 56670 99278 110433248
Breath sounds abnormal 20.17 11.46 42 56731 25362 110507164
Depressed level of consciousness 19.90 11.46 17 56756 112261 110420265
Eosinophilia 19.87 11.46 3 56770 57933 110474593
Joint injury 19.74 11.46 55 56718 39939 110492587
Small intestinal obstruction 19.69 11.46 48 56725 32165 110500361
Back pain 19.61 11.46 283 56490 370713 110161813
International normalised ratio increased 19.29 11.46 92 56681 86680 110445846
Pulmonary hypertension 18.99 11.46 67 56706 55153 110477373
Injection site haemorrhage 18.91 11.46 48 56725 32980 110499546
Injection site erythema 18.91 11.46 97 56676 94079 110438447
Drug intolerance 18.67 11.46 127 56646 406385 110126141
Dry mouth 18.45 11.46 170 56603 199778 110332748
Injection site pain 18.35 11.46 155 56618 177767 110354759
Interstitial lung disease 18.24 11.46 27 56746 139307 110393219
Complication associated with device 18.11 11.46 35 56738 20038 110512488
Urinary tract infection 17.68 11.46 250 56523 326032 110206494
Cellulitis 17.64 11.46 118 56655 125898 110406628
Agranulocytosis 17.48 11.46 5 56768 61755 110470771
Product complaint 17.31 11.46 28 56745 13944 110518582
Dysgeusia 16.88 11.46 76 56697 69909 110462617
Cholestasis 16.88 11.46 6 56767 64512 110468014
Eye swelling 16.86 11.46 46 56727 33002 110499524
Colostomy 16.80 11.46 10 56763 1428 110531098
Lower respiratory tract infection 16.79 11.46 66 56707 243040 110289486
Febrile neutropenia 16.59 11.46 95 56678 316672 110215854
Inflammation 16.38 11.46 48 56725 193190 110339336
Drug reaction with eosinophilia and systemic symptoms 16.38 11.46 11 56762 82084 110450442
Blepharospasm 16.36 11.46 4 56769 54847 110477679
Nasal congestion 16.23 11.46 96 56677 98186 110434340
Cytomegalovirus infection 16.18 11.46 4 56769 54440 110478086
Vaginal haemorrhage 16.01 11.46 38 56735 25036 110507490
Nail disorder 15.83 11.46 5 56768 57930 110474596
Cardiac disorder 15.62 11.46 79 56694 76201 110456325
Hepatitis 15.52 11.46 14 56759 90040 110442486
Flushing 15.22 11.46 99 56674 104637 110427889
Laryngeal pain 15.18 11.46 17 56756 5958 110526568
Drug resistance 15.17 11.46 5 56768 56369 110476157
Sleep disorder due to a general medical condition 15.16 11.46 4 56769 52108 110480418
Cardiovascular disorder 15.09 11.46 35 56738 22725 110509801
Red blood cell sedimentation rate increased 14.95 11.46 11 56762 78291 110454235
Bone erosion 14.60 11.46 3 56770 46368 110486158
Transfusion 14.57 11.46 37 56736 25435 110507091
Coronary artery disease 14.50 11.46 74 56699 71616 110460910
Upper respiratory tract infection 14.39 11.46 116 56657 131212 110401314
Neuropathy peripheral 14.37 11.46 148 56625 179129 110353397
Platelet count decreased 14.31 11.46 181 56592 230262 110302264
Night sweats 13.90 11.46 30 56743 133953 110398573
Chills 13.73 11.46 154 56619 190426 110342100
Bone pain 13.72 11.46 68 56705 65065 110467461
Osteoarthritis 13.64 11.46 48 56725 182575 110349951
Infective pulmonary exacerbation of cystic fibrosis 13.62 11.46 26 56747 14745 110517781
Full blood count abnormal 13.62 11.46 61 56712 55991 110476535
Delirium 13.38 11.46 31 56742 134994 110397532
Red blood cell count decreased 13.30 11.46 68 56705 65855 110466671
Anaphylactic shock 13.14 11.46 5 56768 51541 110480985
Atelectasis 13.02 11.46 45 56728 36667 110495859
Heavy menstrual bleeding 12.93 11.46 27 56746 16338 110516188
Bronchitis 12.76 11.46 130 56643 156902 110375624
Lung opacity 12.64 11.46 22 56751 11630 110520896
Application site erythema 12.64 11.46 15 56758 5595 110526931
Altered state of consciousness 12.50 11.46 7 56766 57619 110474907
Gallbladder disorder 12.50 11.46 31 56742 20998 110511528
Accidental exposure to product 12.50 11.46 5 56768 50003 110482523
Gastrointestinal haemorrhage 12.49 11.46 135 56638 165383 110367143
Rotator cuff syndrome 12.45 11.46 27 56746 16767 110515759
Atrial fibrillation 12.05 11.46 175 56598 229467 110303059
Vomiting 12.03 11.46 577 56196 910098 109622428
Psoriatic arthropathy 12.00 11.46 56 56717 196705 110335821
Pain in jaw 11.91 11.46 55 56718 51122 110481404
Foot deformity 11.87 11.46 5 56768 48475 110484051
Leukopenia 11.87 11.46 38 56735 148753 110383773
Renal impairment 11.87 11.46 53 56720 188392 110344134
Rhabdomyolysis 11.65 11.46 28 56745 120373 110412153
Application site discolouration 11.49 11.46 7 56766 1042 110531484

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CA02 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin A, plain
ATC D02BB01 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
PROTECTIVES AGAINST UV-RADIATION
Protectives against UV-radiation for systemic use
CHEBI has role CHEBI:22586 antioxidant
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:26130 biological pigment
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67200 provitamin A
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:173084 ferroptosis inhibitor
MeSH PA D000072664 Provitamins
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients

Related Drugs by ATC class:

A11CA Vitamin A, plain 1 drug
retinol
D02BB Protectives against UV-radiation for systemic use 1 drug
afamelanotide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Primary hyperoxaluria contraindication 17901006 DOID:2977
Blood coagulation disorder contraindication 64779008 DOID:1247
Wilson's disease contraindication 88518009
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Hemochromatosis contraindication 399187006 DOID:2352
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Core protein Unclassified IC50 4.53 CHEMBL

External reference:

IDSource
4020599 VUID
N0000148286 NUI
D03101 KEGG_DRUG
19143 RXNORM
C0053396 UMLSCUI
CHEBI:17579 CHEBI
BCR PDB_CHEM_ID
CHEMBL1293 ChEMBL_ID
D019207 MESH_DESCRIPTOR_UI
DB06755 DRUGBANK_ID
4229 INN_ID
01YAE03M7J UNII
5280489 PUBCHEM_CID
4269 MMSL
5679 MMSL
6766 MMSL
d01385 MMSL
4017793 VANDF
4020599 VANDF
001003 NDDF
002022 NDDF
103068006 SNOMEDCT_US
329507006 SNOMEDCT_US
01YAE03M7J INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 600 [iU] ORAL UNAPPROVED DRUG OTHER 14 sections
VitafolUltra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 330 ug ORAL unapproved drug other 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 600 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 330 ug ORAL unapproved drug other 14 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 920 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
St. Paul Brands Verestor HUMAN OTC DRUG LABEL 7 13411-861 CAPSULE 300 ug ORAL unapproved drug other 8 sections
JBA Verestor Mega Fiber Powder HUMAN OTC DRUG LABEL 8 13411-862 POWDER 250 ug ORAL unapproved drug other 6 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 1000 [iU] ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 1000 [iU] ORAL unapproved drug other 16 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 17856-0668 TABLET, FILM COATED 920 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Prenatal Plus Vitamins HUMAN PRESCRIPTION DRUG LABEL 15 39328-106 TABLET 276 ug ORAL UNAPPROVED DRUG OTHER 7 sections
Prenatal Vitamins Plus Low Iron HUMAN PRESCRIPTION DRUG LABEL 15 50090-0616 TABLET 276 ug ORAL UNAPPROVED DRUG OTHER 8 sections
PNV Prenatal Plus Multivitamin HUMAN PRESCRIPTION DRUG LABEL 15 50090-0617 TABLET 2000 [iU] ORAL Unapproved drug other 9 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-173 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-174 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-177 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
healthy mamaBE WELL ROUNDED BE WELL ROUNDED HUMAN PRESCRIPTION DRUG LABEL 17 58154-107 TABLET, FILM COATED 4000 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 65162-668 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 68151-2640 TABLET, FILM COATED 920 [iU] ORAL UNAPPROVED DRUG OTHER 8 sections
Prenatal Vitamins Plus Low Iron HUMAN PRESCRIPTION DRUG LABEL 15 68151-5878 TABLET 920 [iU] ORAL Unapproved drug other 9 sections
Prenatal Plus Vitamins HUMAN PRESCRIPTION DRUG LABEL 15 70518-4258 TABLET 276 ug ORAL unapproved drug other 7 sections
Prenate Elite HUMAN PRESCRIPTION DRUG LABEL 18 75854-314 TABLET, COATED 780 ug ORAL unapproved drug other 12 sections
Vitacore HUMAN PRESCRIPTION DRUG LABEL 12 84460-902 TABLET 0.30 mg ORAL unapproved drug other 11 sections
Florraxyl HUMAN PRESCRIPTION DRUG LABEL 12 84460-903 TABLET 300 ug ORAL unapproved drug other 10 sections
Folartex HUMAN PRESCRIPTION DRUG LABEL 12 85477-511 TABLET 300 ug ORAL unapproved drug other 10 sections
Folyra HUMAN PRESCRIPTION DRUG LABEL 12 85477-523 TABLET 300 ug ORAL unapproved drug other 10 sections
Folaten HUMAN PRESCRIPTION DRUG LABEL 12 85477-901 TABLET 300 ug ORAL unapproved drug other 10 sections
Folixia HUMAN PRESCRIPTION DRUG LABEL 12 85477-902 TABLET 0.30 mg ORAL unapproved drug other 11 sections
Nutralyn HUMAN PRESCRIPTION DRUG LABEL 12 85477-903 TABLET 0.30 mg ORAL unapproved drug other 11 sections