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undecylenic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3446 | 112-38-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
a fatty acid with a terminal double bond
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 59 | |||
| kinase-selectivity-class | AXL,BRAF,CDK4,CDK9,CSNK2A2,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,INSR,MAP2K6,MAPK10,MAPK12,MAPK7,MAPK8,MTOR,PLK1,PLK2,PLK3,PTK2,SIK2,STK33,SYK,TEK,TTK,UHMK1,ZAP70 | 28 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Macular degeneration | 1216.29 | 38.59 | 345 | 8842 | 37625 | 90581635 |
| Chronic sinusitis | 544.51 | 38.59 | 167 | 9020 | 23635 | 90595625 |
| Paraesthesia oral | 438.81 | 38.59 | 152 | 9035 | 31507 | 90587753 |
| Vaginal flatulence | 404.17 | 38.59 | 115 | 9072 | 12523 | 90606737 |
| Sedation complication | 383.57 | 38.59 | 118 | 9069 | 16826 | 90602434 |
| Proctitis | 382.76 | 38.59 | 115 | 9072 | 15144 | 90604116 |
| Creatinine renal clearance decreased | 379.16 | 38.59 | 120 | 9067 | 18779 | 90600481 |
| Constipation | 374.03 | 38.59 | 272 | 8915 | 280123 | 90339137 |
| Female genital tract fistula | 373.21 | 38.59 | 117 | 9070 | 17751 | 90601509 |
| Procedural pain | 367.06 | 38.59 | 135 | 9052 | 33225 | 90586035 |
| Radiculopathy | 360.90 | 38.59 | 115 | 9072 | 18390 | 90600870 |
| Vaginal discharge | 355.19 | 38.59 | 115 | 9072 | 19349 | 90599911 |
| Blood calcium decreased | 320.44 | 38.59 | 119 | 9068 | 30063 | 90589197 |
| Oral candidiasis | 287.82 | 38.59 | 115 | 9072 | 35340 | 90583920 |
| Orthostatic hypotension | 282.77 | 38.59 | 119 | 9068 | 41708 | 90577552 |
| Sedation | 269.81 | 38.59 | 120 | 9067 | 48051 | 90571209 |
| Depressed level of consciousness | 248.29 | 38.59 | 129 | 9058 | 72655 | 90546605 |
| Colitis | 241.55 | 38.59 | 125 | 9062 | 69817 | 90549443 |
| Frequent bowel movements | 238.51 | 38.59 | 116 | 9071 | 56819 | 90562441 |
| Colitis ulcerative | 235.21 | 38.59 | 117 | 9070 | 60149 | 90559111 |
| Cognitive disorder | 230.97 | 38.59 | 121 | 9066 | 69286 | 90549974 |
| Haematochezia | 228.52 | 38.59 | 121 | 9066 | 70792 | 90548468 |
| Rectal haemorrhage | 205.69 | 38.59 | 119 | 9068 | 82625 | 90536635 |
| Therapeutic product effect incomplete | 196.23 | 38.59 | 160 | 9027 | 193736 | 90425524 |
| Balance disorder | 193.13 | 38.59 | 121 | 9066 | 96959 | 90522301 |
| Renal function test abnormal | 166.51 | 38.59 | 51 | 9136 | 7140 | 90612120 |
| Creatinine renal clearance increased | 161.64 | 38.59 | 42 | 9145 | 3239 | 90616021 |
| Dyspepsia | 154.65 | 38.59 | 141 | 9046 | 198019 | 90421241 |
| Erythema | 130.01 | 38.59 | 137 | 9050 | 229109 | 90390151 |
| Weight decreased | 120.39 | 38.59 | 169 | 9018 | 379741 | 90239519 |
| Drug ineffective | 119.30 | 38.59 | 357 | 8830 | 1383941 | 89235319 |
| Abdominal pain | 112.18 | 38.59 | 167 | 9020 | 395554 | 90223706 |
| Pain | 107.25 | 38.59 | 279 | 8908 | 996062 | 89623198 |
| Multiple drug therapy | 102.17 | 38.59 | 35 | 9152 | 6974 | 90612286 |
| Mobility decreased | 95.30 | 38.59 | 122 | 9065 | 250612 | 90368648 |
| Anaemia | 86.05 | 38.59 | 139 | 9048 | 352663 | 90266597 |
| Toxicity to various agents | 82.18 | 38.59 | 122 | 9065 | 287724 | 90331536 |
| Hypotension | 79.04 | 38.59 | 128 | 9059 | 325269 | 90293991 |
| Malaise | 78.64 | 38.59 | 179 | 9008 | 585807 | 90033453 |
| Pyrexia | 77.02 | 38.59 | 191 | 8996 | 660294 | 89958966 |
| Infusion related reaction | 72.93 | 38.59 | 142 | 9045 | 416638 | 90202622 |
| Fatigue | 60.42 | 38.59 | 21 | 9166 | 1154002 | 89465258 |
| Off label use | 56.13 | 38.59 | 240 | 8947 | 1102012 | 89517248 |
| Drug abuse | 47.95 | 38.59 | 50 | 9137 | 82297 | 90536963 |
| Condition aggravated | 45.69 | 38.59 | 4 | 9183 | 595541 | 90023719 |
| Fall | 45.48 | 38.59 | 129 | 9058 | 481681 | 90137579 |
| Rash | 39.04 | 38.59 | 16 | 9171 | 796084 | 89823176 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Injection related reaction | 58.68 | 22.72 | 12 | 2297 | 604 | 42618422 |
| Volvulus | 35.32 | 22.72 | 10 | 2299 | 2003 | 42617023 |
| Skin reaction | 33.24 | 22.72 | 13 | 2296 | 7054 | 42611972 |
| Oesophageal injury | 31.38 | 22.72 | 6 | 2303 | 213 | 42618813 |
| Pneumonia aspiration | 26.84 | 22.72 | 22 | 2287 | 50056 | 42568970 |
| Lymphocyte count decreased | 23.36 | 22.72 | 16 | 2293 | 27793 | 42591233 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Chronic sinusitis | 526.25 | 26.98 | 164 | 10827 | 24920 | 110553388 |
| Macular degeneration | 515.41 | 26.98 | 156 | 10835 | 21503 | 110556805 |
| Paraesthesia oral | 424.74 | 26.98 | 150 | 10841 | 33521 | 110544787 |
| Vaginal flatulence | 406.27 | 26.98 | 114 | 10877 | 12030 | 110566278 |
| Female genital tract fistula | 380.15 | 26.98 | 116 | 10875 | 16403 | 110561905 |
| Proctitis | 377.36 | 26.98 | 116 | 10875 | 16811 | 110561497 |
| Sedation complication | 375.54 | 26.98 | 120 | 10871 | 19735 | 110558573 |
| Creatinine renal clearance decreased | 372.51 | 26.98 | 122 | 10869 | 21693 | 110556615 |
| Constipation | 365.67 | 26.98 | 294 | 10697 | 357492 | 110220816 |
| Vaginal discharge | 362.56 | 26.98 | 114 | 10877 | 17794 | 110560514 |
| Procedural pain | 357.43 | 26.98 | 134 | 10857 | 35431 | 110542877 |
| Radiculopathy | 353.96 | 26.98 | 114 | 10877 | 19222 | 110559086 |
| Blood calcium decreased | 320.40 | 26.98 | 124 | 10867 | 35721 | 110542587 |
| Oral candidiasis | 267.30 | 26.98 | 116 | 10875 | 44644 | 110533664 |
| Orthostatic hypotension | 244.29 | 26.98 | 123 | 10868 | 66126 | 110512182 |
| Sedation | 235.53 | 26.98 | 122 | 10869 | 69561 | 110508747 |
| Depressed level of consciousness | 215.93 | 26.98 | 136 | 10855 | 112142 | 110466166 |
| Frequent bowel movements | 215.76 | 26.98 | 116 | 10875 | 71274 | 110507034 |
| Cognitive disorder | 212.14 | 26.98 | 123 | 10868 | 87388 | 110490920 |
| Colitis ulcerative | 207.03 | 26.98 | 116 | 10875 | 77247 | 110501061 |
| Colitis | 196.87 | 26.98 | 124 | 10867 | 102199 | 110476109 |
| Balance disorder | 186.90 | 26.98 | 126 | 10865 | 116434 | 110461874 |
| Haematochezia | 180.74 | 26.98 | 123 | 10868 | 115401 | 110462907 |
| Therapeutic product effect incomplete | 178.82 | 26.98 | 160 | 10831 | 223645 | 110354663 |
| Rectal haemorrhage | 165.04 | 26.98 | 118 | 10873 | 119715 | 110458593 |
| Creatinine renal clearance increased | 158.30 | 26.98 | 42 | 10949 | 3583 | 110574725 |
| Dyspepsia | 157.41 | 26.98 | 139 | 10852 | 190826 | 110387482 |
| Renal function test abnormal | 156.52 | 26.98 | 51 | 10940 | 8895 | 110569413 |
| Erythema | 132.99 | 26.98 | 154 | 10837 | 291293 | 110287015 |
| Pain | 120.52 | 26.98 | 281 | 10710 | 954674 | 109623634 |
| Weight decreased | 113.64 | 26.98 | 182 | 10809 | 467875 | 110110433 |
| Multiple drug therapy | 109.74 | 26.98 | 38 | 10953 | 7976 | 110570332 |
| Mobility decreased | 109.15 | 26.98 | 126 | 10865 | 237296 | 110341012 |
| Abdominal pain | 95.01 | 26.98 | 177 | 10814 | 512812 | 110065496 |
| Infusion related reaction | 88.04 | 26.98 | 145 | 10846 | 381017 | 110197291 |
| Anaemia | 79.93 | 26.98 | 171 | 10820 | 546915 | 110031393 |
| Pyrexia | 72.17 | 26.98 | 224 | 10767 | 898041 | 109680267 |
| Malaise | 68.90 | 26.98 | 183 | 10808 | 671636 | 109906672 |
| Hypotension | 54.95 | 26.98 | 144 | 10847 | 523705 | 110054603 |
| Toxicity to various agents | 54.44 | 26.98 | 136 | 10855 | 480419 | 110097889 |
| Fatigue | 48.04 | 26.98 | 31 | 10960 | 1215927 | 109362381 |
| Fall | 42.42 | 26.98 | 144 | 10847 | 603338 | 109974970 |
| Injection related reaction | 40.21 | 26.98 | 12 | 10979 | 1566 | 110576742 |
| Off label use | 33.12 | 26.98 | 258 | 10733 | 1499927 | 109078381 |
| Nausea | 31.50 | 26.98 | 220 | 10771 | 1235470 | 109342838 |
| Condition aggravated | 31.40 | 26.98 | 17 | 10974 | 734819 | 109843489 |
| Overdose | 29.43 | 26.98 | 69 | 10922 | 233725 | 110344583 |
| Arthralgia | 29.21 | 26.98 | 21 | 10970 | 779611 | 109798697 |
| Drug intolerance | 27.21 | 26.98 | 4 | 10987 | 406508 | 110171800 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D01AE04 | DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Other antifungals for topical use |
| ATC | D01AE54 | DERMATOLOGICALS ANTIFUNGALS FOR DERMATOLOGICAL USE ANTIFUNGALS FOR TOPICAL USE Other antifungals for topical use |
| CHEBI has role | CHEBI:76924 | plant metabolite |
| CHEBI has role | CHEBI:86327 | antifungal drug |
Related Drugs by ATC class:
D01AE Other antifungals for topical use 23 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Tinea pedis | indication | 6020002 | DOID:12403 |
| Tinea corporis | indication | 84849002 | |
| Tinea Infections | indication |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.76 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4019122 | VUID |
| N0000178998 | NUI |
| D02159 | KEGG_DRUG |
| 4019122 | VANDF |
| C0041660 | UMLSCUI |
| CHEBI:39448 | CHEBI |
| CHEMBL1276010 | ChEMBL_ID |
| DB11117 | DRUGBANK_ID |
| 5634 | PUBCHEM_CID |
| C538763 | MESH_SUPPLEMENTAL_RECORD_UI |
| K3D86KJ24N | UNII |
| 10989 | RXNORM |
| 5342 | MMSL |
| 5654 | MMSL |
| 002892 | NDDF |
| 111145002 | SNOMEDCT_US |
| 386990002 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Undesine | HUMAN OTC DRUG LABEL | 2 | 10578-009 | OINTMENT | 5 g | TOPICAL | OTC monograph final | 11 sections |
| Undecylenic Acid | HUMAN OTC DRUG LABEL | 1 | 11673-634 | LIQUID | 25 mg | TOPICAL | OTC monograph final | 15 sections |
| UNDECYLENIC ACID | HUMAN OTC DRUG LABEL | 1 | 11822-0028 | LIQUID | 288 mg | TOPICAL | OTC monograph final | 8 sections |
| Rite Aid Fungal | HUMAN OTC DRUG LABEL | 1 | 11822-0250 | LIQUID | 288 mg | TOPICAL | OTC monograph final | 7 sections |
| RIte AidMaximum Strength Foot Care Anti-fungal Pen | HUMAN OTC DRUG LABEL | 1 | 11822-9650 | LIQUID | 250 mg | TOPICAL | OTC monograph final | 14 sections |
| Pinceladas Goyescas OriginalBrush on Fungicide | HUMAN OTC DRUG LABEL | 1 | 11856-3365 | LIQUID | 100 mg | TOPICAL | OTC monograph final | 8 sections |
| Pinceladas Goyescas OriginalFungicide | HUMAN OTC DRUG LABEL | 1 | 11856-3367 | LIQUID | 100 mg | TOPICAL | OTC monograph final | 8 sections |
| Good Neighbor Anti-Fungal | HUMAN OTC DRUG LABEL | 1 | 24385-676 | LIQUID | 250 mg | TOPICAL | OTC monograph final | 13 sections |
| TopCare AntifungalMaximum Strength | HUMAN OTC DRUG LABEL | 1 | 36800-754 | LIQUID | 25 mg | TOPICAL | OTC Monograph Drug | 13 sections |
| Flexitol Anti Fungal | HUMAN OTC DRUG LABEL | 1 | 43251-3351 | LIQUID | 250 mg | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
| UNDECYLENIC ACID | HUMAN OTC DRUG LABEL | 1 | 49035-987 | LIQUID | 288 mg | TOPICAL | OTC monograph final | 8 sections |
| Undecylenic Acid | HUMAN OTC DRUG LABEL | 1 | 49283-025 | LIQUID | 25 g | TOPICAL | OTC Monograph Drug | 11 sections |
| ANTIFUNGAL | HUMAN OTC DRUG LABEL | 1 | 49283-250 | LIQUID | 25 g | TOPICAL | OTC Monograph Drug | 11 sections |
| TINGAthetes foot | HUMAN OTC DRUG LABEL | 2 | 51769-002 | CREAM | 3.78 g | Cutaneous | OTC monograph final | 8 sections |
| TINGCream | HUMAN OTC DRUG LABEL | 2 | 51769-003 | CREAM | 3.78 g | Cutaneous | OTC monograph final | 8 sections |
| Myco Nail A Antifungal Solution | HUMAN OTC DRUG LABEL | 1 | 52083-242 | LIQUID | 250 mg | TOPICAL | OTC Monograph Drug | 11 sections |
| Fiore Rx Pink Peppermint Pie Antifungal Nail Polish | HUMAN OTC DRUG LABEL | 1 | 52261-0200 | FILM | 0.45 g | TOPICAL | OTC monograph final | 8 sections |
| Fiore Rx Antifungal Nail Lacquer Red Velvet Cake | HUMAN OTC DRUG LABEL | 1 | 52261-0201 | FILM | 0.45 g | TOPICAL | OTC monograph final | 9 sections |
| Fiore Rx Almond Milk Matte Antifungal Nail Lacquer | HUMAN OTC DRUG LABEL | 1 | 52261-0202 | FILM | 0.45 g | TOPICAL | OTC monograph final | 8 sections |
| Fiore Rx Rock Candy Clear Antifungal Nail Lacquer | HUMAN OTC DRUG LABEL | 1 | 52261-0203 | FILM | 0.45 g | TOPICAL | OTC monograph final | 8 sections |
| Fiore Rx Pixie Dust Pink Antifungal Nail Polish | HUMAN OTC DRUG LABEL | 1 | 52261-0204 | FILM | 0.45 g | TOPICAL | OTC monograph final | 8 sections |
| Fiore Rx Eggplant My Garden Antifungal Nail Polish | HUMAN OTC DRUG LABEL | 1 | 52261-0205 | FILM | 0.45 g | TOPICAL | OTC monograph final | 8 sections |
| Fiore Rx CranApple Crush Antifungal Nail Polish | HUMAN OTC DRUG LABEL | 1 | 52261-0206 | FILM | 0.45 g | TOPICAL | OTC monograph final | 9 sections |
| Fiore Rx Coral Sorbet Antifungal Nail Polish | HUMAN OTC DRUG LABEL | 1 | 52261-0207 | FILM | 0.45 g | TOPICAL | OTC monograph final | 8 sections |
| Fiore Rx Antifungal ProPen | HUMAN OTC DRUG LABEL | 1 | 52261-2500 | LIQUID | 0.50 g | TOPICAL | OTC monograph final | 8 sections |
| Botanimedix OnychoRX Antifungal Nail Gel | HUMAN OTC DRUG LABEL | 1 | 52261-5800 | GEL | 0.25 kg | TOPICAL | OTC monograph final | 11 sections |
| FungicureMaximum Strength | HUMAN OTC DRUG LABEL | 1 | 52389-198 | LIQUID | 250 mg | TOPICAL | Export only | 1 sections |
| Fungicure LiquidGel | HUMAN OTC DRUG LABEL | 1 | 52389-633 | GEL | 250 mg | TOPICAL | Export only | 1 sections |
| Hongocura | HUMAN OTC DRUG LABEL | 2 | 53145-017 | OINTMENT | 5 g | TOPICAL | OTC Monograph Drug | 10 sections |
| Hongocura Pinceladas | HUMAN OTC DRUG LABEL | 1 | 53145-019 | LIQUID | 200 mg | TOPICAL | OTC Monograph Drug | 12 sections |