valaciclovir 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antivirals bicyclic heterocycle compounds 2798 124832-27-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • valacyclovir
  • valaciclovir
  • valcivir
  • valacyclovir hydrochloride
  • valacyclovir HCl
A prodrug of acyclovir that is used in the treatment of HERPES ZOSTER and HERPES SIMPLEX VIRUS INFECTION of the skin and mucous membranes, including GENITAL HERPES.
  • Molecular weight: 324.34
  • Formula: C13H20N6O4
  • CLOGP: -1.22
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 3
  • TPSA: 146.85
  • ALOGS: -1.97
  • ROTB: 8
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
3 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 174 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 154.16 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
fu (Fraction unbound in plasma) 1 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K
BA (Bioavailability) 54 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.040 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.133 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.092 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 0.995 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 86.930 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 69.560 % High 1
herg hERG pIC50 3.665 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 2.495 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 6.223 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 83.870 % High 1
kinase-safety-class ACVR2B,EIF2AK3,GRK2,PDK1,PDK2,PRKDC 6
kinase-selectivity-class AXL,CDK1,CDK16,CDK2,CDK3,CDK9,MAP3K21,PDK1 8
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.914 High 1
mh-clint Mouse hepatocyte intrinsic clearance 37.931 High 1
mppb Mouse plasma protein binding (% unbound) 87.400 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.681 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 87.060 % High 1
rh-clint Rat hepatocyte intrinsic clearance 14.289 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 94.620 % High 1
rppb Rat plasma protein binding (% unbound) 67.630 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 922.571 uM High 1

Approvals:

DateAgencyCompanyOrphan
June 23, 1995 FDA GLAXOSMITHKLINE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 655.18 9.83 836 98331 157513 90371767
Cytokine release syndrome 497.68 9.83 335 98832 27638 90501642
Acute kidney injury 483.91 9.83 1076 98091 319311 90209969
Plasma cell myeloma 453.20 9.83 368 98799 40460 90488820
Pemphigus 340.95 9.83 3 99164 326861 90202419
Neutropenia 326.46 9.83 744 98423 224160 90305120
Neurotoxicity 325.33 9.83 233 98934 21234 90508046
Synovitis 315.58 9.83 10 99157 329742 90199538
Altered state of consciousness 314.11 9.83 267 98900 31265 90498015
Hand deformity 307.76 9.83 3 99164 296359 90232921
Toxic encephalopathy 292.70 9.83 157 99010 8542 90520738
Glossodynia 284.14 9.83 17 99150 321762 90207518
Systemic lupus erythematosus 271.94 9.83 37 99130 361859 90167421
Contraindicated product administered 267.96 9.83 22 99145 320117 90209163
Agranulocytosis 250.05 9.83 246 98921 34756 90494524
Drug reaction with eosinophilia and systemic symptoms 238.11 9.83 263 98904 42495 90486785
Helicobacter infection 228.01 9.83 4 99163 226846 90302434
Wound 225.16 9.83 32 99135 302948 90226332
Encephalopathy 222.03 9.83 264 98903 46180 90483100
Hepatocellular injury 207.73 9.83 204 98963 28754 90500526
Rash maculo-papular 197.85 9.83 234 98933 40699 90488581
Herpes zoster 193.68 9.83 361 98806 94283 90434997
Arthropathy 189.16 9.83 82 99085 366160 90163120
Joint swelling 187.60 9.83 165 99002 503135 90026145
Oral herpes 182.85 9.83 204 98963 33320 90495960
Drug intolerance 178.86 9.83 137 99030 447454 90081826
Muscle injury 177.98 9.83 3 99164 176651 90352629
Pericarditis 177.94 9.83 39 99128 270112 90259168
Febrile bone marrow aplasia 176.46 9.83 118 99049 9620 90519660
Folliculitis 173.85 9.83 13 99154 204340 90324940
Toxic skin eruption 168.30 9.83 139 99028 15635 90513645
Treatment failure 166.79 9.83 62 99105 303866 90225414
Hepatic cytolysis 163.27 9.83 185 98982 30731 90498549
Pancytopenia 162.38 9.83 387 98780 119876 90409404
Swelling 160.23 9.83 134 99033 418924 90110356
Thrombocytopenia 155.29 9.83 542 98625 208183 90321097
Rheumatoid factor positive 154.74 9.83 8 99159 171642 90357638
Dyslalia 154.32 9.83 49 99118 669 90528611
Therapeutic product effect decreased 150.00 9.83 58 99109 277513 90251767
Dysarthria 148.49 9.83 236 98931 54246 90475034
Impaired healing 145.98 9.83 38 99129 234161 90295119
Hepatic enzyme increased 142.04 9.83 112 99055 360624 90168656
Type 2 diabetes mellitus 138.65 9.83 27 99140 203217 90326063
Mobility decreased 137.80 9.83 51 99116 250683 90278597
Immune effector cell-associated neurotoxicity syndrome 134.62 9.83 82 99085 5686 90523594
Neuropathy peripheral 133.14 9.83 390 98777 136580 90392700
Drug hypersensitivity 132.20 9.83 189 98978 463420 90065860
COVID-19 131.28 9.83 445 98722 168398 90360882
Alopecia 129.50 9.83 214 98953 494857 90034423
Rheumatoid arthritis 127.77 9.83 125 99042 362489 90166791
Blood urea increased 123.03 9.83 159 99008 30254 90499026
Abdominal discomfort 121.46 9.83 210 98957 477118 90052162
Herpes simplex 119.79 9.83 95 99072 10086 90519194
Irritable bowel syndrome 117.73 9.83 40 99127 207408 90321872
Psoriatic arthropathy 111.80 9.83 55 99112 228280 90301000
Drug ineffective 109.02 9.83 981 98186 1383317 89145963
C-reactive protein abnormal 108.66 9.83 8 99159 127421 90401859
Cholestasis 108.36 9.83 164 99003 36135 90493145
Herpes virus infection 102.97 9.83 72 99095 6312 90522968
Fibromyalgia 102.02 9.83 49 99118 206220 90323060
White blood cell count decreased 101.76 9.83 407 98760 166702 90362578
Platelet count decreased 97.78 9.83 351 98816 136618 90392662
Blood creatinine increased 96.89 9.83 287 98880 101099 90428181
Joint range of motion decreased 94.67 9.83 17 99150 135626 90393654
Pyrexia 93.27 9.83 1118 98049 659367 89869913
Acute generalised exanthematous pustulosis 89.93 9.83 92 99075 13611 90515669
Infusion related reaction 87.45 9.83 205 98962 416575 90112705
Liver injury 85.13 9.83 40 99127 170527 90358753
Maternal exposure during pregnancy 84.77 9.83 166 99001 359897 90169383
Musculoskeletal stiffness 81.40 9.83 124 99043 296408 90232872
Product use issue 81.26 9.83 148 99019 329771 90199509
Discomfort 79.94 9.83 110 99057 274225 90255055
Septic shock 79.23 9.83 237 98930 83923 90445357
Eosinophilia 78.28 9.83 124 99043 28409 90500871
Diarrhoea 78.12 9.83 1451 97716 937739 89591541
Blood cholesterol increased 77.59 9.83 68 99099 207944 90321336
Lower respiratory tract infection 75.57 9.83 98 99069 250561 90278719
Hypersensitivity 74.41 9.83 252 98915 454425 90074855
Nervous system disorder 73.79 9.83 104 99063 21489 90507791
Bursitis 73.61 9.83 26 99141 131628 90397652
Blister 73.53 9.83 103 99064 254895 90274385
Tumour lysis syndrome 73.41 9.83 75 99092 11077 90518203
Grip strength decreased 73.03 9.83 8 99159 92568 90436712
Lip dry 71.88 9.83 12 99155 100943 90428337
Intentional overdose 71.81 9.83 9 99158 93825 90435455
Hypercholesterolaemia 69.64 9.83 13 99154 100879 90428401
Gastrointestinal disorder 68.85 9.83 109 99058 256578 90272702
Nephropathy toxic 68.81 9.83 77 99090 12611 90516669
Cryopyrin associated periodic syndrome 67.99 9.83 25 99142 543 90528737
Obesity 67.88 9.83 16 99151 105491 90423789
Osteoarthritis 66.00 9.83 70 99097 195660 90333620
Acute myeloid leukaemia 65.53 9.83 96 99071 20544 90508736
Graft versus host disease 65.26 9.83 61 99106 8083 90521197
Peripheral venous disease 64.34 9.83 8 99159 83913 90445367
Escherichia bacteraemia 64.25 9.83 52 99115 5683 90523597
Vocal cord dysfunction 62.99 9.83 27 99140 887 90528393
Laryngitis fungal 61.69 9.83 18 99149 181 90529099
Hallucination, visual 60.13 9.83 98 99069 22994 90506286
Prescribed overdose 58.62 9.83 17 99150 97608 90431672
Gait inability 58.17 9.83 45 99122 146411 90382869
Drug abuse 58.15 9.83 10 99157 82337 90446943
Wound infection 57.82 9.83 22 99145 106380 90422900
Rectal prolapse 57.49 9.83 34 99133 2233 90527047
Lymphopenia 56.75 9.83 95 99072 22786 90506494
Dermatitis atopic 56.29 9.83 96 99071 23376 90505904
Neutrophil count decreased 55.95 9.83 189 98978 71343 90457937
Injury 54.63 9.83 82 99085 197267 90332013
Completed suicide 54.59 9.83 47 99120 145011 90384269
COVID-19 pneumonia 54.06 9.83 82 99085 18095 90511185
Product tampering 54.02 9.83 20 99147 443 90528837
Diffuse large B-cell lymphoma refractory 53.68 9.83 30 99137 1770 90527510
Sciatica 53.38 9.83 22 99145 101360 90427920
Posterior reversible encephalopathy syndrome 53.08 9.83 91 99076 22248 90507032
Aplasia 52.97 9.83 40 99127 3951 90525329
Dermatitis exfoliative generalised 52.91 9.83 46 99121 5547 90523733
Injection site inflammation 52.62 9.83 42 99125 4499 90524781
Lower limb fracture 52.54 9.83 14 99153 84999 90444281
Therapeutic product effect incomplete 52.30 9.83 82 99085 193814 90335466
Pain 52.28 9.83 772 98395 995569 89533711
Ophthalmic herpes simplex 51.02 9.83 21 99146 622 90528658
Red blood cell sedimentation rate increased 50.30 9.83 14 99153 82581 90446699
Laryngeal stenosis 50.25 9.83 26 99141 1313 90527967
Bronchopulmonary aspergillosis 48.32 9.83 61 99106 11337 90517943
Hip arthroplasty 48.15 9.83 12 99155 76196 90453084
Depressed level of consciousness 48.11 9.83 182 98985 72602 90456678
Musculoskeletal pain 47.55 9.83 71 99096 171180 90358100
Ill-defined disorder 47.24 9.83 81 99086 184810 90344470
Wheezing 46.82 9.83 121 99046 237959 90291321
Adulterated product 45.90 9.83 17 99150 377 90528903
Blepharospasm 45.81 9.83 4 99163 55441 90473839
Renal impairment 45.53 9.83 232 98935 105189 90424091
Encephalitis cytomegalovirus 45.42 9.83 20 99147 702 90528578
Human herpesvirus 6 encephalitis 45.12 9.83 17 99150 396 90528884
Hyperthermia 44.91 9.83 56 99111 10279 90519001
Hepatic cirrhosis 43.97 9.83 8 99159 63245 90466035
Sepsis 43.38 9.83 341 98826 179473 90349807
Acute pulmonary oedema 43.38 9.83 53 99114 9527 90519753
Disorientation 43.19 9.83 126 99041 43988 90485292
Renal disorder 42.85 9.83 114 99053 37745 90491535
Pulmonary fibrosis 42.72 9.83 33 99134 107470 90421810
Post herpetic neuralgia 42.66 9.83 30 99137 2654 90526626
Thrombotic microangiopathy 42.61 9.83 68 99099 15675 90513605
Knee arthroplasty 42.28 9.83 19 99148 83163 90446117
Claustrophobia 41.99 9.83 23 99144 1304 90527976
Peripheral swelling 41.52 9.83 273 98894 412833 90116447
Feeling abnormal 40.81 9.83 318 98849 166917 90362363
Full blood count decreased 40.53 9.83 96 99071 29593 90499687
Arthralgia 40.49 9.83 604 98563 777918 89751362
Hallucination 40.39 9.83 161 99006 65798 90463482
Renal tubular disorder 40.05 9.83 31 99136 3176 90526104
Cytomegalovirus infection 39.59 9.83 89 99078 26513 90502767
Onychomadesis 38.88 9.83 3 99164 45995 90483285
Renal failure 38.82 9.83 261 98906 130746 90398534
Skin lesion 38.79 9.83 109 99058 37256 90492024
Metabolic encephalopathy 38.38 9.83 42 99125 6710 90522570
Prescribed underdose 38.34 9.83 17 99150 75002 90454278
Psychiatric symptom 38.26 9.83 43 99124 7075 90522205
Somatic symptom disorder 38.12 9.83 31 99136 3410 90525870
Inflammation 38.07 9.83 87 99080 178505 90350775
Neurological symptom 37.90 9.83 42 99125 6805 90522475
Hypophagia 37.47 9.83 105 99062 35832 90493448
Autoimmune disorder 36.76 9.83 19 99148 76725 90452555
Weight increased 36.75 9.83 287 98880 417640 90111640
Stomatitis 36.71 9.83 165 99002 274533 90254747
Lupus-like syndrome 36.61 9.83 5 99162 48841 90480439
General physical health deterioration 36.53 9.83 233 98934 354882 90174398
Incorrect dosage administered 36.49 9.83 28 99139 2832 90526448
Bladder prolapse 36.39 9.83 25 99142 2130 90527150
Deep vein thrombosis 36.38 9.83 197 98970 91423 90437857
Foreign body in reproductive tract 36.14 9.83 20 99147 1157 90528123
Antiviral drug level above therapeutic 36.00 9.83 8 99159 22 90529258
Mixed liver injury 35.87 9.83 43 99124 7580 90521700
Hypertension 35.81 9.83 324 98843 457208 90072072
Pneumonia 35.67 9.83 932 98235 637127 89892153
Cheilitis 35.39 9.83 35 99132 4972 90524308
Myoclonus 35.35 9.83 70 99097 19098 90510182
Subretinal haematoma 35.35 9.83 9 99158 51 90529229
Diffuse large B-cell lymphoma 34.65 9.83 45 99122 8600 90520680
Fluid replacement 34.64 9.83 16 99151 629 90528651
Plasma cell myeloma recurrent 34.52 9.83 32 99135 4196 90525084
Chills 34.46 9.83 255 98912 131726 90397554
Road traffic accident 33.54 9.83 41 99126 107585 90421695
Crystalluria 33.53 9.83 15 99152 547 90528733
Contusion 33.50 9.83 151 99016 251065 90278215
Eyelid irritation 33.37 9.83 18 99149 990 90528290
Erdheim-Chester disease 33.36 9.83 9 99158 66 90529214
Night sweats 33.26 9.83 56 99111 128710 90400570
Constipation 33.23 9.83 460 98707 279935 90249345
Gamma-glutamyltransferase increased 33.02 9.83 104 99063 37848 90491432
Suicide attempt 32.79 9.83 21 99146 75378 90453902
Lymphocyte count decreased 32.31 9.83 98 99069 34952 90494328
Urine output decreased 32.15 9.83 53 99114 12550 90516730
Oedema 32.04 9.83 112 99055 200183 90329097
Fear of disease 31.94 9.83 20 99147 1456 90527824
Ischaemic stroke 31.70 9.83 73 99094 22093 90507187
Mucosal inflammation 30.85 9.83 135 99032 57490 90471790
Cerebellar stroke 30.79 9.83 13 99154 411 90528869
Ophthalmic herpes zoster 30.64 9.83 25 99142 2763 90526517
Exostosis 30.55 9.83 10 99157 53124 90476156
Pulse abnormal 30.50 9.83 26 99141 3053 90526227
Genital herpes simplex 30.30 9.83 13 99154 428 90528852
Epstein-Barr virus associated lymphoma 30.23 9.83 15 99152 693 90528587
Vision blurred 29.88 9.83 215 98952 110078 90419202
Ectropion 29.70 9.83 11 99156 244 90529036
Bone marrow failure 29.62 9.83 90 99077 32131 90497149
Cholestatic liver injury 29.58 9.83 28 99139 3769 90525511
Disease progression 29.39 9.83 281 98886 156334 90372946
Pathogen resistance 29.09 9.83 40 99127 8075 90521205
Cytopenia 28.96 9.83 61 99106 17388 90511892
Bacterial sepsis 28.48 9.83 31 99136 4924 90524356
Bacteraemia 28.18 9.83 70 99097 22230 90507050
Cutaneous vasculitis 28.14 9.83 37 99130 7156 90522124
Serotonin syndrome 28.11 9.83 4 99163 37883 90491397
Clostridium difficile colitis 27.81 9.83 78 99089 26628 90502652
Genital herpes 27.60 9.83 21 99146 2097 90527183
Aplastic anaemia 27.60 9.83 51 99116 13218 90516062
Product dose omission issue 27.40 9.83 460 98707 291227 90238053
X-ray abnormal 27.10 9.83 8 99159 45416 90483864
Epilepsy 27.03 9.83 30 99137 82176 90447104
Toxic erythema of chemotherapy 26.91 9.83 10 99157 224 90529056
Illness 26.53 9.83 167 99000 81802 90447478
Coeliac disease 26.35 9.83 8 99159 44602 90484678
Dry mouth 26.14 9.83 108 99059 183951 90345329
Vitamin D decreased 26.13 9.83 47 99120 11932 90517348
Hypogammaglobulinaemia 26.04 9.83 44 99123 10630 90518650
Macular degeneration 25.97 9.83 5 99162 37965 90491315
Chronic lymphocytic leukaemia 25.89 9.83 24 99143 3146 90526134
Fungal endocarditis 25.82 9.83 11 99156 356 90528924
Walking aid user 25.76 9.83 4 99163 35502 90493778
Finger deformity 25.55 9.83 3 99164 32894 90496386
Hepatitis acute 25.41 9.83 44 99123 10843 90518437
Toxicity to various agents 25.12 9.83 198 98969 287648 90241632
Intracranial pressure increased 25.06 9.83 34 99133 6777 90522503
Nail disorder 24.94 9.83 17 99150 59050 90470230
Cerebral ventricle dilatation 24.74 9.83 15 99152 1031 90528249
Liver function test increased 24.71 9.83 34 99133 84821 90444459
Loss of personal independence in daily activities 24.63 9.83 72 99095 136033 90393247
Herpes ophthalmic 24.45 9.83 17 99150 1477 90527803
Pneumocystis jirovecii pneumonia 24.37 9.83 65 99102 21551 90507729
Serum amyloid A protein increased 24.28 9.83 13 99154 704 90528576
Cryptosporidiosis infection 24.24 9.83 11 99156 415 90528865
Squamous cell carcinoma of skin 24.16 9.83 35 99132 7414 90521866
Infective aneurysm 23.95 9.83 11 99156 427 90528853
Product administration interrupted 23.50 9.83 46 99121 12446 90516834
Inappropriate antidiuretic hormone secretion 23.37 9.83 60 99107 19445 90509835
Haemophagocytic lymphohistiocytosis 23.32 9.83 52 99115 15407 90513873
Cytomegalovirus chorioretinitis 23.10 9.83 20 99147 2399 90526881
Joint dislocation 22.94 9.83 10 99157 44572 90484708
Emotional distress 22.85 9.83 90 99077 36572 90492708
Foot deformity 22.83 9.83 19 99148 59632 90469648
Bronchiolitis 22.55 9.83 23 99144 3389 90525891
Plasmacytoma 22.53 9.83 21 99146 2772 90526508
Sleep disorder 22.42 9.83 126 99041 197904 90331376
Speech disorder 22.31 9.83 104 99063 45481 90483799
Incorrect route of product administration 22.15 9.83 14 99153 50612 90478668
Mucormycosis 22.12 9.83 24 99143 3797 90525483
Pneumonia parainfluenzae viral 22.12 9.83 10 99157 374 90528906
Intentional self-injury 21.99 9.83 3 99164 29331 90499949
Product quality issue 21.90 9.83 33 99134 79292 90449988
Spina bifida 21.80 9.83 13 99154 867 90528413
Progressive multifocal leukoencephalopathy 21.78 9.83 51 99116 15604 90513676
Restlessness 21.71 9.83 87 99080 35633 90493647
Embedded device 21.71 9.83 25 99142 4223 90525057
Sedation 21.52 9.83 13 99154 48158 90481122
Hyperreflexia 21.18 9.83 31 99136 6626 90522654
Anaemia 21.03 9.83 520 98647 352282 90176998
Cell death 20.94 9.83 21 99146 3034 90526246
Blood immunoglobulin E increased 20.88 9.83 25 99142 4400 90524880
Eye infection bacterial 20.85 9.83 9 99158 301 90528979
Urinary tract infection 20.84 9.83 459 98708 305173 90224107
Tumour flare 20.73 9.83 11 99156 585 90528695
Venoocclusive liver disease 20.67 9.83 29 99138 5964 90523316
Dry skin 20.66 9.83 166 99001 87907 90441373
Bicytopenia 20.65 9.83 23 99144 3748 90525532
Epstein-Barr virus infection 20.57 9.83 39 99128 10305 90518975
Mucosal excoriation 20.51 9.83 4 99163 4 90529276
Asthma 20.47 9.83 168 98999 241992 90287288
Streptococcal bacteraemia 20.43 9.83 18 99149 2209 90527071
Jugular vein occlusion 20.33 9.83 6 99161 63 90529217
Complication of device insertion 20.33 9.83 39 99128 10397 90518883
Tractional retinal detachment 20.24 9.83 6 99161 64 90529216
Neuralgia 20.18 9.83 78 99089 31422 90497858
Biopsy skin abnormal 20.11 9.83 7 99160 129 90529151
Pseudolymphoma 20.00 9.83 11 99156 629 90528651
Intentional product use issue 19.95 9.83 147 99020 216745 90312535
Neuropsychiatric syndrome 19.91 9.83 6 99161 68 90529212
Adverse event 19.90 9.83 64 99103 117354 90411926
Plasma cell myeloma refractory 19.62 9.83 13 99154 1043 90528237
Congenital herpes simplex infection 19.62 9.83 4 99163 6 90529274
Leukopenia 19.54 9.83 182 98985 100528 90428752
Cholecystitis chronic 19.48 9.83 37 99130 9789 90519491
Drug resistance 19.18 9.83 75 99092 30374 90498906
Acute respiratory distress syndrome 19.17 9.83 72 99095 28614 90500666
Blood uric acid increased 19.12 9.83 32 99135 7672 90521608
Intensive care 19.11 9.83 14 99153 1320 90527960
Erythrosis 19.09 9.83 6 99161 79 90529201
Blood lactate dehydrogenase increased 18.95 9.83 67 99100 25865 90503415
Pregnancy 18.95 9.83 24 99143 62023 90467257
Eye pain 18.92 9.83 97 99070 44071 90485209
Back injury 18.92 9.83 14 99153 46608 90482672
Thrombosis 18.81 9.83 141 99026 73110 90456170
Hepatitis E 18.74 9.83 16 99151 1883 90527397
Crystal nephropathy 18.61 9.83 13 99154 1138 90528142
Taste disorder 18.59 9.83 24 99143 61522 90467758
Pancreatitis acute 18.55 9.83 77 99090 32038 90497242
Macrocytosis 18.52 9.83 19 99148 2819 90526461
Bacterial vaginosis 18.46 9.83 15 99152 1648 90527632
Nausea 18.41 9.83 1431 97736 1108885 89420395
Arterial intramural haematoma 18.35 9.83 7 99160 169 90529111
Monoclonal immunoglobulin increased 18.21 9.83 9 99158 412 90528868
Anal infection 18.20 9.83 6 99161 93 90529187
Adverse reaction 18.15 9.83 5 99162 29707 90499573
Campylobacter colitis 18.15 9.83 5 99162 40 90529240
Live birth 18.13 9.83 37 99130 79070 90450210
Rash pustular 18.10 9.83 32 99135 8017 90521263
Herpes simplex viraemia 18.03 9.83 9 99158 421 90528859
Meningoencephalitis herpetic 18.00 9.83 14 99153 1445 90527835
Mycobacterium tuberculosis complex test positive 17.98 9.83 18 99149 2594 90526686
Drug monitoring procedure not performed 17.88 9.83 11 99156 776 90528504
Rhinovirus infection 17.87 9.83 27 99140 5936 90523344
Partial seizures 17.81 9.83 30 99137 7230 90522050
Klebsiella test positive 17.63 9.83 14 99153 1489 90527791
Neutrophil morphology abnormal 17.50 9.83 4 99163 13 90529267
Congenital pyelocaliectasis 17.46 9.83 3 99164 0 90529280
Sopor 17.38 9.83 3 99164 24641 90504639
Vitiligo 17.28 9.83 16 99151 2094 90527186
Condition aggravated 17.25 9.83 508 98659 595037 89934243
Venoocclusive disease 17.05 9.83 17 99150 2438 90526842
Aspergillus infection 17.00 9.83 37 99130 10786 90518494
Cough 16.96 9.83 526 98641 368436 90160844
Portal vein cavernous transformation 16.87 9.83 6 99161 118 90529162
Infective chondritis 16.86 9.83 4 99163 16 90529264
Anaphylactic reaction 16.80 9.83 45 99122 87479 90441801
Chronic papillomatous dermatitis 16.65 9.83 5 99162 56 90529224
Dermatitis exfoliative 16.50 9.83 25 99142 5511 90523769
Lichenification 16.44 9.83 9 99158 510 90528770
Mycobacterial peritonitis 16.34 9.83 5 99162 60 90529220
Bone marrow necrosis 16.29 9.83 6 99161 131 90529149
Klebsiella bacteraemia 16.28 9.83 17 99150 2575 90526705
Rhegmatogenous retinal detachment 16.25 9.83 6 99161 132 90529148
Laryngeal inflammation 16.12 9.83 6 99161 135 90529145
Gastrointestinal viral infection 16.07 9.83 13 99154 1420 90527860
Urea renal clearance decreased 15.97 9.83 4 99163 21 90529259
Laboratory test abnormal 15.94 9.83 89 99078 41765 90487515
Pseudomyopia 15.90 9.83 5 99162 66 90529214
Influenza 15.88 9.83 227 98940 139037 90390243
Visual acuity reduced 15.85 9.83 59 99108 23351 90505929
Interstitial lung disease 15.80 9.83 140 99027 76265 90453015
Hypoglycaemic seizure 15.80 9.83 9 99158 551 90528729
Monocyte percentage increased 15.79 9.83 12 99155 1196 90528084
Alpha haemolytic streptococcal infection 15.74 9.83 14 99153 1740 90527540
Escherichia pyelonephritis 15.68 9.83 10 99157 752 90528528
Meningitis 15.67 9.83 31 99136 8450 90520830
Metastases to liver 15.57 9.83 6 99161 28801 90500479
Disability 15.57 9.83 13 99154 40732 90488548
Granulicatella infection 15.53 9.83 6 99161 150 90529130
Bacterial diarrhoea 15.53 9.83 6 99161 150 90529130
Mycetoma mycotic 15.52 9.83 4 99163 24 90529256
Terminal ileitis 15.43 9.83 12 99155 1238 90528042
Cerebral thrombosis 15.41 9.83 14 99153 1789 90527491
Citrobacter sepsis 15.38 9.83 3 99164 3 90529277
Underdose 15.37 9.83 22 99145 53995 90475285
Herpes simplex reactivation 15.30 9.83 11 99156 1008 90528272
Eye infection toxoplasmal 15.28 9.83 8 99159 414 90528866
HCoV-OC43 infection 15.24 9.83 4 99163 26 90529254
SARS-CoV-2 test positive 15.20 9.83 36 99131 11092 90518188
Fungal infection 15.12 9.83 89 99078 42572 90486708
Acute febrile neutrophilic dermatosis 15.07 9.83 19 99148 3526 90525754
Ulcer haemorrhage 15.05 9.83 5 99162 26316 90502964
Toxic epidermal necrolysis 15.04 9.83 73 99094 32455 90496825
Erythema multiforme 15.01 9.83 38 99129 12208 90517072
Scab 15.00 9.83 33 99134 9688 90519592
Central nervous system necrosis 14.96 9.83 6 99161 166 90529114
Atrial fibrillation 14.92 9.83 217 98950 133394 90395886
Unevaluable event 14.90 9.83 107 99060 54741 90474539
Somnolence 14.88 9.83 316 98851 208768 90320512
Cytomegalovirus test positive 14.87 9.83 19 99148 3572 90525708
Limbic encephalitis 14.86 9.83 7 99160 288 90528992
Graft versus host disease in gastrointestinal tract 14.79 9.83 21 99146 4367 90524913
Aphthous ulcer 14.70 9.83 47 99120 17240 90512040
Conjunctivitis 14.63 9.83 63 99104 26643 90502637
Pneumonia influenzal 14.63 9.83 15 99152 2225 90527055
Bone marrow transplant 14.58 9.83 10 99157 850 90528430
Conjunctivitis viral 14.57 9.83 7 99160 301 90528979
Ataxia 14.39 9.83 48 99119 17994 90511286
Dyspepsia 14.33 9.83 143 99024 198017 90331263
Complication of device removal 14.23 9.83 25 99142 6230 90523050
Onychomycosis 14.19 9.83 12 99155 37364 90491916
Incoherent 14.16 9.83 22 99145 4955 90524325
Exposure during pregnancy 14.11 9.83 180 98987 238230 90291050
Thermal burn 14.08 9.83 26 99141 6736 90522544
Limb injury 14.06 9.83 70 99097 31438 90497842
Abdominal pain upper 14.00 9.83 268 98899 332406 90196874
Facial paralysis 13.91 9.83 43 99124 15491 90513789
Acute lymphocytic leukaemia recurrent 13.88 9.83 16 99151 2705 90526575
Imperception 13.85 9.83 3 99164 7 90529273
Human ehrlichiosis 13.80 9.83 6 99161 204 90529076
Cytomegalovirus infection reactivation 13.80 9.83 28 99139 7772 90521508
Leukaemia recurrent 13.75 9.83 12 99155 1455 90527825
International normalised ratio increased 13.73 9.83 19 99148 47297 90481983
Blood bilirubin increased 13.71 9.83 88 99079 43382 90485898
Oropharyngeal pain 13.63 9.83 189 98978 114998 90414282
Soliloquy 13.56 9.83 7 99160 352 90528928
Dyspnoea 13.48 9.83 808 98359 880147 89649133
Drug interaction 13.45 9.83 217 98950 276236 90253044
Urticaria 13.45 9.83 251 98916 312483 90216797
Tremor 13.44 9.83 239 98928 152934 90376346
Disturbance in attention 13.44 9.83 93 99074 47016 90482264
Symmetrical drug-related intertriginous and flexural exanthema 13.41 9.83 10 99157 969 90528311
CSF cell count increased 13.38 9.83 4 99163 44 90529236
Maternal exposure timing unspecified 13.34 9.83 4 99163 22479 90506801
Embolism 13.31 9.83 31 99136 9450 90519830
Monocyte morphology abnormal 13.31 9.83 3 99164 9 90529271
Acute lymphocytic leukaemia 13.29 9.83 16 99151 2832 90526448
Tri-iodothyronine free increased 13.28 9.83 6 99161 224 90529056
Acute motor-sensory axonal neuropathy 13.27 9.83 7 99160 368 90528912
Bronchitis 13.20 9.83 238 98929 152689 90376591
Seasonal allergy 13.19 9.83 55 99112 22928 90506352
Cardiac failure 13.10 9.83 180 98987 109316 90419964
Clostridium difficile infection 13.10 9.83 76 99091 36169 90493111
Oliguria 13.06 9.83 33 99134 10591 90518689
Subacute combined cord degeneration 13.01 9.83 6 99161 235 90529045
Asthenia 12.98 9.83 711 98456 533040 89996240
Feeling cold 12.96 9.83 62 99105 27403 90501877
Escherichia sepsis 12.92 9.83 23 99144 5793 90523487
Pulmonary embolism 12.89 9.83 208 98959 130612 90398668
Starvation 12.88 9.83 8 99159 574 90528706
Pain in extremity 12.86 9.83 385 98782 450144 90079136
Gingival ulceration 12.84 9.83 10 99157 1034 90528246
Biliary dyskinesia 12.79 9.83 15 99152 2584 90526696
Dermo-hypodermitis 12.78 9.83 9 99158 798 90528482
Neurosis 12.76 9.83 7 99160 398 90528882
Paranoia 12.76 9.83 37 99130 12871 90516409
Aminoaciduria 12.76 9.83 5 99162 130 90529150
Malnutrition 12.75 9.83 47 99120 18511 90510769
Liver disorder 12.74 9.83 79 99088 121190 90408090
Pneumocystis jirovecii infection 12.71 9.83 13 99154 1923 90527357
Tongue oedema 12.67 9.83 22 99145 5432 90523848
Aortic valve disease 12.59 9.83 11 99156 1335 90527945
Nasal herpes 12.59 9.83 9 99158 817 90528463
Pyelitis 12.51 9.83 6 99161 257 90529023
Stress 12.40 9.83 140 99027 81255 90448025
Pelvic pain 12.38 9.83 41 99126 15316 90513964
Dehydration 12.30 9.83 289 98878 194158 90335122
Varicella zoster virus infection 12.26 9.83 18 99149 3859 90525421
Allogenic stem cell transplantation 12.15 9.83 5 99162 148 90529132
Bone pain 12.01 9.83 112 99055 61871 90467409
Face oedema 12.00 9.83 54 99113 23264 90506016
Albumin urine present 11.99 9.83 6 99161 282 90528998
Therapeutic product ineffective 11.99 9.83 14 99153 2400 90526880
Kussmaul respiration 11.98 9.83 6 99161 283 90528997
White blood cell morphology abnormal 11.94 9.83 3 99164 16 90529264
Chloasma 11.88 9.83 5 99162 157 90529123
Product substitution issue 11.87 9.83 45 99122 17963 90511317
Cardiomyopathy acute 11.84 9.83 6 99161 290 90528990
Dysphonia 11.73 9.83 113 99054 62971 90466309
Oculomucocutaneous syndrome 11.70 9.83 5 99162 163 90529117
Lymphadenopathy 11.69 9.83 88 99079 45687 90483593
Nystagmus 11.69 9.83 25 99142 7202 90522078
Alexithymia 11.68 9.83 4 99163 70 90529210
Brain injury 11.64 9.83 26 99141 7712 90521568
Meningocele 11.64 9.83 3 99164 18 90529262
Neutropenic infection 11.61 9.83 12 99155 1797 90527483
Enteritis 11.60 9.83 31 99136 10290 90518990
Vaccination failure 11.52 9.83 10 99157 1203 90528077
Herpes zoster oticus 11.48 9.83 7 99160 486 90528794
Grimacing 11.40 9.83 7 99160 492 90528788
Clubbing 11.39 9.83 7 99160 493 90528787
Thrombotic thrombocytopenic purpura 11.37 9.83 18 99149 4120 90525160
Respiratory syncytial virus infection 11.30 9.83 31 99136 10449 90518831
CD4 lymphocytes decreased 11.28 9.83 11 99156 1536 90527744
Failure to thrive 11.26 9.83 27 99140 8384 90520896
Lymphocyte morphology abnormal 11.25 9.83 7 99160 504 90528776
Light chain analysis increased 11.19 9.83 11 99156 1551 90527729
Respiratory distress 11.17 9.83 77 99090 38869 90490411
Benign hydatidiform mole 11.08 9.83 5 99162 186 90529094
Gallbladder disorder 11.06 9.83 47 99120 19756 90509524
Amenorrhoea 11.01 9.83 33 99134 11689 90517591
Gastric cancer 11.01 9.83 20 99147 5116 90524164
Cells in urine 10.98 9.83 5 99162 190 90529090
Hepatitis cholestatic 10.95 9.83 27 99140 8534 90520746
Joint stiffness 10.95 9.83 46 99121 77996 90451284
Periarthritis 10.93 9.83 15 99152 3022 90526258
Psychiatric decompensation 10.89 9.83 12 99155 1931 90527349
Hyponatraemia 10.89 9.83 206 98961 133332 90395948
Autonomic nervous system imbalance 10.88 9.83 16 99151 3434 90525846
Adrenal insufficiency 10.88 9.83 10 99157 29911 90499369
Neuroendocrine carcinoma 10.86 9.83 6 99161 346 90528934
Rectal haemorrhage 10.86 9.83 50 99117 82694 90446586
Nail discomfort 10.83 9.83 4 99163 88 90529192
Immune-mediated enterocolitis 10.81 9.83 19 99148 4738 90524542
Arthritis 10.78 9.83 124 99043 167191 90362089
Mean cell haemoglobin increased 10.75 9.83 17 99150 3888 90525392
Cerebral venous thrombosis 10.74 9.83 13 99154 2315 90526965
Blood pressure systolic abnormal 10.71 9.83 46 99121 19432 90509848
Lymphocyte adoptive therapy 10.68 9.83 3 99164 26 90529254
Red blood cell count decreased 10.67 9.83 87 99080 46264 90483016
Multiple organ dysfunction syndrome 10.62 9.83 118 99049 68218 90461062
Pharyngeal inflammation 10.60 9.83 9 99158 1051 90528229
Hyperuricaemia 10.59 9.83 23 99144 6696 90522584
CD8 lymphocytes decreased 10.54 9.83 5 99162 209 90529071
Pseudomonas infection 10.51 9.83 38 99129 14827 90514453
Asterixis 10.49 9.83 11 99156 1674 90527606
Gingival bleeding 10.46 9.83 38 99129 14865 90514415
Ageusia 10.45 9.83 40 99127 16036 90513244
Bone density decreased 10.45 9.83 3 99164 17342 90511938
Tympanic membrane perforation 10.43 9.83 13 99154 2384 90526896
Dermatitis 10.37 9.83 50 99117 22170 90507110
Rash morbilliform 10.35 9.83 17 99150 4012 90525268
Dyskinesia 10.35 9.83 72 99095 36462 90492818
Nephritis 10.34 9.83 15 99152 3180 90526100
Middle insomnia 10.34 9.83 41 99126 16710 90512570
Central nervous system lymphoma 10.30 9.83 12 99155 2053 90527227
Gingival erosion 10.22 9.83 5 99162 224 90529056
Haemolytic anaemia 10.13 9.83 32 99135 11665 90517615
Acute graft versus host disease 10.12 9.83 20 99147 5448 90523832
Electrolyte imbalance 10.07 9.83 52 99115 23693 90505587
Gastrooesophageal reflux disease 10.06 9.83 125 99042 166212 90363068
Medication error 10.05 9.83 53 99114 84599 90444681
Hemianopia homonymous 10.02 9.83 8 99159 857 90528423
Rash macular 9.99 9.83 62 99105 30218 90499062
Diverticulitis 9.97 9.83 84 99083 45103 90484177
Dry eye 9.92 9.83 102 99065 57829 90471451
White matter lesion 9.91 9.83 13 99154 2508 90526772
Uterine perforation 9.85 9.83 24 99143 7530 90521750
Autoimmune nephritis 9.85 9.83 6 99161 416 90528864

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 748.66 10.87 1237 73222 184466 42362410
Cytokine release syndrome 699.25 10.87 597 73862 43930 42502946
Plasma cell myeloma 363.94 10.87 432 74027 47146 42499730
Neutropenia 311.31 10.87 907 73552 198524 42348352
Drug reaction with eosinophilia and systemic symptoms 274.93 10.87 353 74106 41722 42505154
Neurotoxicity 261.72 10.87 261 74198 23390 42523486
Rash maculo-papular 242.43 10.87 313 74146 37190 42509686
Acute generalised exanthematous pustulosis 217.31 10.87 153 74306 8442 42538434
Agranulocytosis 204.93 10.87 260 74199 30352 42516524
Thrombocytopenia 202.95 10.87 761 73698 189518 42357358
Pyrexia 192.30 10.87 1260 73199 392782 42154094
Febrile bone marrow aplasia 170.88 10.87 142 74317 10039 42536837
Hepatic cytolysis 170.26 10.87 222 74237 26622 42520254
Encephalopathy 162.55 10.87 273 74186 41060 42505816
Immune effector cell-associated neurotoxicity syndrome 158.88 10.87 132 74327 9329 42537547
Acute kidney injury 135.94 10.87 1100 73359 366237 42180639
Drug abuse 133.24 10.87 14 74445 104757 42442119
Pancytopenia 132.95 10.87 480 73979 117263 42429613
Completed suicide 122.38 10.87 13 74446 96452 42450424
Toxic skin eruption 120.60 10.87 134 74325 13596 42533280
Toxicity to various agents 117.95 10.87 136 74323 229000 42317876
Drug ineffective 117.43 10.87 636 73823 629561 41917315
Hepatocellular injury 114.59 10.87 172 74287 23506 42523370
Dermatitis exfoliative generalised 114.24 10.87 89 74370 5735 42541141
Toxic encephalopathy 104.44 10.87 91 74368 6862 42540014
Cholestasis 103.37 10.87 197 74262 32682 42514194
Pneumonia 91.60 10.87 1132 73327 421017 42125859
Dyslalia 90.39 10.87 36 74423 599 42546277
Cytopenia 84.51 10.87 127 74332 17370 42529506
Herpes zoster 82.96 10.87 199 74260 38678 42508198
Neuropathy peripheral 82.76 10.87 375 74084 101478 42445398
Aplastic anaemia 80.97 10.87 104 74355 12280 42534596
Microsporidia infection 78.62 10.87 39 74420 1113 42545763
Nervous system disorder 73.54 10.87 118 74341 17077 42529799
Tumour lysis syndrome 70.85 10.87 134 74325 22097 42524779
White blood cell count decreased 70.81 10.87 380 74079 110016 42436860
Dysarthria 69.60 10.87 189 74270 39618 42507258
Bronchopulmonary aspergillosis 69.36 10.87 123 74336 19306 42527570
Squamous cell carcinoma of skin 65.24 10.87 95 74364 12631 42534245
Eosinophilia 64.46 10.87 163 74296 32736 42514140
Chronic lymphocytic leukaemia 62.27 10.87 58 74401 4771 42542105
Intentional overdose 60.22 10.87 9 74450 51447 42495429
Mucosal inflammation 59.69 10.87 206 74253 49168 42497708
Drug interaction 58.98 10.87 253 74206 266746 42280130
Lymphopenia 57.91 10.87 121 74338 21442 42525434
Face oedema 57.37 10.87 93 74366 13573 42533303
Suicide attempt 56.47 10.87 7 74452 46093 42500783
Septic shock 55.71 10.87 311 74148 91361 42455515
Ophthalmic herpes simplex 55.57 10.87 22 74437 360 42546516
Intentional product misuse 54.44 10.87 20 74439 61880 42484996
Acute myeloid leukaemia 54.16 10.87 120 74339 22136 42524740
Altered state of consciousness 53.24 10.87 141 74318 29118 42517758
COVID-19 51.50 10.87 363 74096 115585 42431291
Cerebral toxoplasmosis 49.92 10.87 36 74423 2062 42544814
Hypoglycaemia 49.90 10.87 21 74438 59833 42487043
Rhinovirus infection 49.24 10.87 59 74400 6489 42540387
Neutrophil count decreased 47.44 10.87 228 74231 63187 42483689
Pathogen resistance 46.82 10.87 77 74382 11373 42535503
Genital herpes 46.74 10.87 24 74435 738 42546138
Platelet count decreased 46.71 10.87 407 74052 138174 42408702
Hypogammaglobulinaemia 45.99 10.87 78 74381 11813 42535063
Parainfluenzae virus infection 45.53 10.87 43 74416 3600 42543276
Therapeutic product effect incomplete 44.73 10.87 35 74424 70904 42475972
Pseudomonas infection 43.52 10.87 90 74369 15833 42531043
Escherichia sepsis 41.94 10.87 51 74408 5696 42541180
Mixed liver injury 41.60 10.87 45 74414 4429 42542447
Squamous cell carcinoma 41.05 10.87 78 74381 12904 42533972
Drug hypersensitivity 41.03 10.87 69 74390 99320 42447556
Aplasia 40.36 10.87 46 74413 4797 42542079
Graft versus host disease in gastrointestinal tract 39.76 10.87 47 74412 5096 42541780
Klebsiella bacteraemia 39.72 10.87 33 74426 2331 42544545
Escherichia bacteraemia 39.72 10.87 47 74412 5102 42541774
Demodicidosis 39.57 10.87 15 74444 217 42546659
Dyspnoea 39.38 10.87 541 73918 442080 42104796
Diffuse large B-cell lymphoma 39.22 10.87 64 74395 9390 42537486
Graft versus host disease 37.63 10.87 75 74384 12850 42534026
Rhabdomyolysis 37.22 10.87 49 74410 77970 42468906
Purpura 37.10 10.87 71 74388 11808 42535068
Hyperuricaemia 36.69 10.87 62 74397 9362 42537514
Bradycardia 34.68 10.87 60 74399 85424 42461452
Polymyositis 34.56 10.87 27 74432 1746 42545130
Stress 34.53 10.87 17 74442 44195 42502681
Drug dependence 34.25 10.87 5 74454 29089 42517787
Pain 34.15 10.87 269 74190 244579 42302297
International normalised ratio increased 34.03 10.87 21 74438 48147 42498729
Malignant neoplasm progression 34.00 10.87 88 74371 108312 42438564
Anxiety 33.66 10.87 101 74358 118459 42428417
Increased viscosity of upper respiratory secretion 33.33 10.87 15 74444 342 42546534
Hyperleukocytosis 33.00 10.87 31 74428 2577 42544299
Encephalitis 32.71 10.87 58 74401 9100 42537776
Mantle cell lymphoma recurrent 32.53 10.87 21 74438 1002 42545874
Herpes simplex 32.14 10.87 50 74409 7045 42539831
Bone marrow failure 31.58 10.87 128 74331 32965 42513911
Congenital herpes simplex infection 31.28 10.87 8 74451 26 42546850
Respiratory tract infection viral 31.22 10.87 34 74425 3372 42543504
Hyperhidrosis 31.13 10.87 70 74389 90442 42456434
Haematochezia 30.74 10.87 34 74425 58402 42488474
Bacteraemia 30.71 10.87 105 74354 24935 42521941
Aspergillus infection 30.53 10.87 78 74381 15759 42531117
Death 30.35 10.87 611 73848 470574 42076302
Infection 30.21 10.87 314 74145 111754 42435122
Aggression 30.17 10.87 20 74439 44143 42502733
Musculoskeletal stiffness 29.96 10.87 34 74425 57731 42489145
Colitis 29.61 10.87 160 74299 46412 42500464
Depression 29.41 10.87 98 74361 111265 42435611
Lung disorder 29.36 10.87 163 74296 47760 42499116
Nephritis allergic 29.06 10.87 17 74442 679 42546197
Respiratory tract infection bacterial 28.70 10.87 25 74434 1884 42544992
Atrial fibrillation 28.64 10.87 371 74088 139222 42407654
Donor leukocyte infusion 28.63 10.87 9 74450 71 42546805
Angina pectoris 28.30 10.87 11 74448 32885 42513991
SARS-CoV-2 sepsis 27.97 10.87 12 74447 243 42546633
Pneumonia fungal 27.75 10.87 54 74405 9092 42537784
Herpes zoster reactivation 27.74 10.87 14 74445 415 42546461
Escherichia infection 27.22 10.87 61 74398 11335 42535541
Drug withdrawal syndrome 27.07 10.87 3 74456 21546 42525330
Confusional state 27.03 10.87 427 74032 167170 42379706
Pneumonia haemophilus 27.03 10.87 19 74440 1045 42545831
Wrong technique in product usage process 26.92 10.87 21 74438 42614 42504262
Plasma cell myeloma recurrent 26.68 10.87 41 74418 5716 42541160
Streptococcal bacteraemia 26.40 10.87 28 74431 2694 42544182
Conjunctival irritation 26.31 10.87 9 74450 95 42546781
Inappropriate schedule of product administration 26.29 10.87 83 74376 95819 42451057
Drug resistance 26.23 10.87 124 74335 34124 42512752
Hypercalcaemia 26.01 10.87 80 74379 17978 42528898
Bronchopneumopathy 25.99 10.87 15 74444 584 42546292
Myocardial infarction 25.81 10.87 120 74339 123889 42422987
Differentiation syndrome 25.77 10.87 23 74436 1790 42545086
Cardiac arrest 25.69 10.87 101 74358 109219 42437657
Tumour flare 25.66 10.87 19 74440 1134 42545742
Coronary artery disease 25.35 10.87 34 74425 53686 42493190
Thrombotic microangiopathy 24.65 10.87 69 74390 14713 42532163
Lymphocyte count decreased 24.53 10.87 105 74354 27704 42519172
Wheezing 24.53 10.87 36 74423 54745 42492131
Blood creatine phosphokinase increased 24.47 10.87 29 74430 48309 42498567
Pulmonary sarcoidosis 24.40 10.87 16 74443 784 42546092
Rash 24.16 10.87 644 73815 276310 42270566
Obstructive airways disorder 23.51 10.87 7 74452 24752 42522124
COVID-19 pneumonia 23.40 10.87 87 74372 21526 42525350
Sedation 23.37 10.87 12 74447 30463 42516413
Peripheral sensory neuropathy 23.33 10.87 49 74410 8713 42538163
Mantle cell lymphoma 23.27 10.87 20 74439 1480 42545396
Sleep disorder 23.15 10.87 30 74429 48065 42498811
Respiratory depression 22.78 10.87 3 74456 18865 42528011
Eosinophilic colitis 22.47 10.87 11 74448 305 42546571
Vomiting 22.28 10.87 364 74095 289359 42257517
Varicella zoster virus infection 22.17 10.87 25 74434 2576 42544300
Nightmare 22.12 10.87 8 74451 25004 42521872
Haemophagocytic lymphohistiocytosis 21.98 10.87 76 74383 18146 42528730
Bacterial sepsis 21.81 10.87 40 74419 6442 42540434
Infective exacerbation of chronic obstructive airways disease 21.67 10.87 22 74437 2011 42544865
Myositis 21.54 10.87 66 74393 14800 42532076
Pneumocystis jirovecii pneumonia 21.38 10.87 94 74365 25087 42521789
Medication error 21.35 10.87 16 74443 33138 42513738
Incorrect route of product administration 21.12 10.87 8 74451 24297 42522579
Herpes virus infection 21.05 10.87 29 74430 3663 42543213
Tender joint count decreased 21.01 10.87 10 74449 260 42546616
Swollen joint count decreased 21.01 10.87 10 74449 260 42546616
Lactic acidosis 21.00 10.87 29 74430 45232 42501644
Basal cell carcinoma 20.95 10.87 87 74372 22646 42524230
Keratitis bacterial 20.72 10.87 8 74451 122 42546754
Lymphocytosis 20.67 10.87 26 74433 3005 42543871
Respiratory tract infection 20.66 10.87 96 74363 26226 42520650
Cytomegalovirus infection 20.54 10.87 111 74348 32195 42514681
Injection site pain 20.45 10.87 44 74415 57754 42489122
Blood pressure increased 20.41 10.87 100 74359 101828 42445048
Pseudomonal bacteraemia 20.38 10.87 23 74436 2373 42544503
Cerebrovascular accident 20.23 10.87 94 74365 97066 42449810
Delirium 20.20 10.87 159 74300 52360 42494516
Swollen tongue 20.17 10.87 6 74453 21225 42525651
Serotonin syndrome 20.09 10.87 10 74449 25835 42521041
Loss of consciousness 20.03 10.87 88 74371 92266 42454610
Bone hypertrophy 19.95 10.87 10 74449 292 42546584
Melaena 19.88 10.87 23 74436 38723 42508153
Botryomycosis 19.83 10.87 6 74453 41 42546835
Hallucination, visual 19.81 10.87 81 74378 20939 42525937
Campylobacter test positive 19.81 10.87 7 74452 82 42546794
Pericarditis 19.77 10.87 60 74399 13384 42533492
Ophthalmic herpes zoster 19.71 10.87 16 74443 1094 42545782
Ischaemic stroke 19.65 10.87 84 74375 22149 42524727
Oesophagitis 19.63 10.87 65 74394 15182 42531694
Folliculitis 19.59 10.87 35 74424 5523 42541353
Influenza 19.57 10.87 180 74279 61995 42484881
Chest pain 19.56 10.87 153 74306 139377 42407499
Malignant neoplasm of unknown primary site 19.47 10.87 11 74448 411 42546465
Citrobacter infection 19.38 10.87 13 74446 662 42546214
Hyperthermia 19.33 10.87 57 74402 12517 42534359
Ichthyosis 19.26 10.87 8 74451 149 42546727
Alpha haemolytic streptococcal infection 19.22 10.87 20 74439 1882 42544994
Atypical haemolytic uraemic syndrome 19.08 10.87 12 74447 547 42546329
Renal tubular disorder 18.72 10.87 32 74427 4877 42541999
Nocardiosis 18.70 10.87 33 74426 5157 42541719
Cerebellar syndrome 18.70 10.87 24 74435 2831 42544045
Blood glucose increased 18.68 10.87 66 74393 73633 42473243
Monoclonal immunoglobulin present 18.66 10.87 16 74443 1180 42545696
Staphylococcal bacteraemia 18.63 10.87 52 74407 11069 42535807
Myelodysplastic syndrome 18.63 10.87 84 74375 22661 42524215
Glomerulosclerosis 18.55 10.87 14 74445 860 42546016
Palpitations 18.53 10.87 38 74421 50759 42496117
Facial paralysis 18.41 10.87 56 74403 12507 42534369
Fusarium infection 18.17 10.87 18 74441 1598 42545278
Respiratory arrest 17.94 10.87 14 74445 28410 42518466
Laryngeal cancer metastatic 17.92 10.87 6 74453 59 42546817
Hallucination 17.86 10.87 166 74293 57341 42489535
Mutism 17.78 10.87 17 74442 1445 42545431
Vaccination failure 17.68 10.87 17 74442 1455 42545421
Haematemesis 17.68 10.87 16 74443 30183 42516693
Acute myocardial infarction 17.63 10.87 48 74411 58117 42488759
Labelled drug-drug interaction medication error 17.61 10.87 3 74456 15579 42531297
Loss of personal independence in daily activities 17.56 10.87 38 74421 49778 42497098
Arthritis 17.54 10.87 29 74430 42036 42504840
Condition aggravated 17.37 10.87 336 74123 260418 42286458
Acute HIV infection 17.32 10.87 6 74453 66 42546810
Drug ineffective for unapproved indication 17.30 10.87 34 74425 46129 42500747
Rectal abscess 17.27 10.87 18 74441 1697 42545179
Viral mutation identified 17.26 10.87 25 74434 3306 42543570
Arteriosclerosis 17.24 10.87 5 74454 17984 42528892
No adverse event 17.12 10.87 26 74433 38995 42507881
Acute pulmonary oedema 17.08 10.87 43 74416 8608 42538268
Positive end-expiratory pressure 17.03 10.87 4 74455 8 42546868
End stage renal disease 17.02 10.87 4 74455 16554 42530322
Genital erythema 16.97 10.87 9 74450 296 42546580
Obesity 16.87 10.87 4 74455 16455 42530421
SJS-TEN overlap 16.86 10.87 12 74447 673 42546203
Retinal detachment 16.80 10.87 36 74423 6489 42540387
Suicidal ideation 16.76 10.87 37 74422 48124 42498752
SAPHO syndrome 16.66 10.87 10 74449 419 42546457
Psychiatric symptom 16.64 10.87 28 74431 4213 42542663
Fall 16.60 10.87 299 74160 234221 42312655
Disseminated mucormycosis 16.59 10.87 16 74443 1375 42545501
Herpes ophthalmic 16.52 10.87 12 74447 695 42546181
Stomatitis 16.50 10.87 147 74312 50182 42496694
Ventricular fibrillation 16.42 10.87 17 74442 30106 42516770
Metastases to bone 16.41 10.87 3 74456 14806 42532070
Pain in extremity 16.39 10.87 176 74283 150428 42396448
Colitis ulcerative 16.38 10.87 13 74446 26162 42520714
Headache 16.38 10.87 307 74152 239062 42307814
Aphasia 16.16 10.87 84 74375 23999 42522877
Full blood count decreased 16.15 10.87 75 74384 20485 42526391
Chest discomfort 16.10 10.87 57 74402 63559 42483317
Toxic neuropathy 15.99 10.87 11 74448 584 42546292
Graft versus host disease in lung 15.92 10.87 12 74447 736 42546140
Bladder cancer 15.86 10.87 5 74454 17042 42529834
Pneumonia pneumococcal 15.82 10.87 21 74438 2560 42544316
Abdominal distension 15.77 10.87 68 74391 71667 42475209
Congestive cardiomyopathy 15.70 10.87 42 74417 8722 42538154
Morganella infection 15.60 10.87 11 74448 608 42546268
Aeromonas infection 15.58 10.87 9 74450 351 42546525
Neutropenic colitis 15.57 10.87 28 74431 4442 42542434
Oral herpes 15.42 10.87 38 74421 7506 42539370
Fluid imbalance 15.42 10.87 9 74450 358 42546518
Pancreatitis acute 15.41 10.87 106 74353 33458 42513418
Urinary tract infection pseudomonal 15.39 10.87 15 74444 1306 42545570
Heart rate increased 15.37 10.87 45 74414 53210 42493666
Product quality issue 15.34 10.87 6 74453 17876 42529000
CSF cell count increased 15.32 10.87 5 74454 45 42546831
Dermatitis exfoliative 15.28 10.87 36 74423 6911 42539965
Blood uric acid abnormal 15.26 10.87 8 74451 257 42546619
Periorbital cellulitis 15.26 10.87 9 74450 365 42546511
Stem cell transplant 15.25 10.87 21 74438 2651 42544225
Blood immunoglobulin M abnormal 15.22 10.87 6 74453 97 42546779
Dyscalculia 15.17 10.87 6 74453 98 42546778
Herpes zoster oticus 15.15 10.87 8 74451 261 42546615
Soft tissue infection 15.12 10.87 21 74438 2672 42544204
Klebsiella sepsis 15.07 10.87 21 74438 2680 42544196
Blood immunoglobulin G abnormal 15.05 10.87 6 74453 100 42546776
Out of specification test results 15.04 10.87 5 74454 48 42546828
Chronic obstructive pulmonary disease 15.02 10.87 58 74401 63056 42483820
Brief psychotic disorder with marked stressors 15.01 10.87 8 74451 266 42546610
Haemorrhoids thrombosed 14.95 10.87 8 74451 268 42546608
Herpes zoster meningoencephalitis 14.95 10.87 10 74449 507 42546369
Blood lactate dehydrogenase increased 14.85 10.87 87 74372 25994 42520882
Hypercapnic coma 14.82 10.87 7 74452 179 42546697
Optic neuropathy 14.73 10.87 20 74439 2492 42544384
Enterococcal sepsis 14.69 10.87 18 74441 2026 42544850
Deafness congenital 14.68 10.87 6 74453 107 42546769
Pneumonia aspiration 14.68 10.87 42 74417 50036 42496840
Hemiparesis 14.63 10.87 6 74453 17370 42529506
Immunoglobulins decreased 14.63 10.87 13 74446 1006 42545870
Dermatitis bullous 14.62 10.87 40 74419 8416 42538460
Pulmonary fibrosis 14.61 10.87 15 74444 26666 42520210
Somnolence 14.52 10.87 167 74292 140938 42405938
Pulmonary sepsis 14.47 10.87 23 74436 3301 42543575
Cardiogenic shock 14.46 10.87 25 74434 35615 42511261
Logorrhoea 14.45 10.87 21 74438 2786 42544090
Withdrawal syndrome 14.36 10.87 4 74455 14771 42532105
Bronchial haemorrhage 14.33 10.87 11 74448 693 42546183
Transient ischaemic attack 14.31 10.87 23 74436 33716 42513160
Incorrect disposal of product 14.26 10.87 9 74450 413 42546463
Poisoning 14.25 10.87 4 74455 14695 42532181
Haemorrhage 14.19 10.87 56 74403 60507 42486369
Metabolic acidosis 14.12 10.87 45 74414 51813 42495063
Flushing 14.11 10.87 27 74432 37001 42509875
Blood creatinine abnormal 14.10 10.87 22 74437 3107 42543769
Retinopathy sickle cell 13.98 10.87 3 74456 3 42546873
Blood osmolarity abnormal 13.98 10.87 3 74456 3 42546873
Staphylococcal infection 13.95 10.87 113 74346 37530 42509346
Sopor 13.95 10.87 3 74456 13199 42533677
Neutropenic sepsis 13.90 10.87 60 74399 15886 42530990
Bicytopenia 13.81 10.87 22 74437 3162 42543714
Platelet disorder 13.81 10.87 18 74441 2156 42544720
Enterococcal bacteraemia 13.80 10.87 20 74439 2647 42544229
Aspiration 13.78 10.87 7 74452 17879 42528997
Salmonellosis 13.75 10.87 14 74445 1284 42545592
Venous thrombosis 13.70 10.87 25 74434 4010 42542866
Hepatitis cholestatic 13.66 10.87 43 74416 9781 42537095
Antiviral drug level above therapeutic 13.61 10.87 5 74454 66 42546810
Human herpesvirus 6 encephalitis 13.59 10.87 10 74449 591 42546285
Complications of transplanted heart 13.57 10.87 8 74451 324 42546552
Peripheral T-cell lymphoma unspecified 13.52 10.87 10 74449 596 42546280
Lymphocytic infiltration 13.44 10.87 12 74447 934 42545942
Arteriosclerosis coronary artery 13.39 10.87 8 74451 18669 42528207
JC virus infection 13.37 10.87 21 74438 2983 42543893
General physical health deterioration 13.33 10.87 185 74274 151061 42395815
Meningoencephalitis amoebic 13.26 10.87 7 74452 228 42546648
Intentional self-injury 13.21 10.87 5 74454 15197 42531679
Human herpesvirus 6 infection 13.16 10.87 19 74440 2506 42544370
CSF volume increased 13.14 10.87 4 74455 28 42546848
Amyotrophy 13.13 10.87 9 74450 475 42546401
Laryngeal inflammation 13.13 10.87 6 74453 142 42546734
Abdominal pain 13.11 10.87 244 74215 190227 42356649
Retinitis 12.98 10.87 9 74450 484 42546392
Contraindicated product administered 12.96 10.87 15 74444 25257 42521619
Allogenic stem cell transplantation 12.82 10.87 6 74453 150 42546726
Dry mouth 12.78 10.87 32 74427 39847 42507029
Swelling 12.70 10.87 51 74408 54834 42492042
Pneumonia viral 12.68 10.87 25 74434 4249 42542627
Sepsis 12.66 10.87 446 74013 198888 42347988
Diarrhoea 12.63 10.87 951 73508 459898 42086978
Human bocavirus infection 12.62 10.87 5 74454 82 42546794
Movement disorder 12.50 10.87 5 74454 14693 42532183
Myoclonus 12.49 10.87 61 74398 17004 42529872
Haemolytic anaemia 12.45 10.87 48 74411 12079 42534797
Pulmonary congestion 12.35 10.87 6 74453 15724 42531152
Disseminated cryptococcosis 12.32 10.87 16 74443 1909 42544967
Plasmacytoma 12.32 10.87 25 74434 4339 42542537
Platelet transfusion 12.31 10.87 15 74444 1679 42545197
Disorientation 12.30 10.87 107 74352 36282 42510594
Pneumonia influenzal 12.29 10.87 16 74443 1913 42544963
Mixed dementia 12.26 10.87 7 74452 267 42546609
Circulatory collapse 12.15 10.87 14 74445 23622 42523254
Action tremor 12.14 10.87 5 74454 91 42546785
Progressive multifocal leukoencephalopathy 12.12 10.87 46 74413 11490 42535386
Appendicitis 11.97 10.87 11 74448 20602 42526274
Heart rate decreased 11.95 10.87 29 74430 36503 42510373
Enterobacter pneumonia 11.94 10.87 9 74450 552 42546324
Hepatic encephalopathy 11.84 10.87 7 74452 16435 42530441
Iron deficiency anaemia 11.82 10.87 4 74455 13035 42533841
Lymphocytic lymphoma 11.80 10.87 4 74455 41 42546835
Sleep disorder due to a general medical condition 11.79 10.87 8 74451 17445 42529431
Injury 11.71 10.87 13 74446 22303 42524573
Bacillus bacteraemia 11.64 10.87 6 74453 186 42546690
Blood cholesterol increased 11.56 10.87 18 74441 26723 42520153
Arthralgia 11.46 10.87 272 74187 204966 42341910
Acute lymphocytic leukaemia recurrent 11.45 10.87 22 74437 3669 42543207
Bone pain 11.44 10.87 76 74383 23716 42523160
Cyanosis 11.40 10.87 6 74453 15025 42531851
Arthritis fungal 11.40 10.87 5 74454 107 42546769
Peripheral T-cell lymphoma unspecified recurrent 11.38 10.87 4 74455 46 42546830
Drug intolerance 11.35 10.87 88 74371 80336 42466540
Pemphigoid 11.34 10.87 3 74456 11464 42535412
Ulcerative keratitis 11.31 10.87 16 74443 2072 42544804
Renal disorder 11.29 10.87 88 74371 28892 42517984
Blood sodium decreased 11.27 10.87 62 74397 18100 42528776
Hepatic function abnormal 11.26 10.87 49 74410 51518 42495358
Congenital brain damage 11.25 10.87 3 74456 12 42546864
Gamma-glutamyltransferase abnormal 11.24 10.87 8 74451 449 42546427
Hyperbilirubinaemia 11.21 10.87 68 74391 20567 42526309
Bronchitis 11.20 10.87 129 74330 47072 42499804
Atrioventricular block complete 11.19 10.87 3 74456 11361 42535515
Septic embolus 11.13 10.87 13 74446 1392 42545484
Giant cell arteritis 11.05 10.87 12 74447 1186 42545690
Acute febrile neutrophilic dermatosis 11.04 10.87 15 74444 1869 42545007
Salmonella bacteraemia 11.02 10.87 8 74451 463 42546413

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 1501.32 9.89 1954 142497 314813 110130035
Cytokine release syndrome 1218.63 9.89 887 143564 69419 110375429
Plasma cell myeloma 642.15 9.89 583 143868 62353 110382495
Neutropenia 629.72 9.89 1461 142990 373159 110071689
Neurotoxicity 618.85 9.89 482 143969 41725 110403123
Acute kidney injury 576.09 9.89 1980 142471 633450 109811398
Drug reaction with eosinophilia and systemic symptoms 537.79 9.89 598 143853 81497 110363351
Agranulocytosis 482.47 9.89 494 143957 61266 110383582
Rash maculo-papular 471.32 9.89 532 143919 73690 110371158
Thrombocytopenia 388.78 9.89 1168 143283 347717 110097131
Hepatic cytolysis 355.27 9.89 398 144053 54655 110390193
Toxic encephalopathy 353.24 9.89 230 144221 14984 110429864
Febrile bone marrow aplasia 324.44 9.89 230 144221 17235 110427613
Encephalopathy 323.51 9.89 461 143990 80594 110364254
Immune effector cell-associated neurotoxicity syndrome 315.40 9.89 212 144239 14570 110430278
Hepatocellular injury 307.92 9.89 355 144096 50287 110394561
Toxic skin eruption 298.56 9.89 264 144187 27251 110417597
Pyrexia 295.81 9.89 2095 142356 896170 109548678
Pancytopenia 295.67 9.89 765 143686 208848 110236000
Acute generalised exanthematous pustulosis 284.56 9.89 232 144219 21432 110423416
Synovitis 280.72 9.89 20 144431 274072 110170776
Pemphigus 251.47 9.89 6 144445 214564 110230284
Systemic lupus erythematosus 240.30 9.89 26 144425 254312 110190536
Cholestasis 227.19 9.89 346 144105 64172 110380676
Glossodynia 219.45 9.89 19 144432 221985 110222863
Helicobacter infection 217.42 9.89 4 144447 181873 110262975
Contraindicated product administered 213.90 9.89 34 144417 248233 110196615
Drug intolerance 208.92 9.89 137 144314 406375 110038473
Duodenal ulcer perforation 204.36 9.89 6 144445 177694 110267154
Joint swelling 197.19 9.89 173 144278 442672 110002176
Altered state of consciousness 194.42 9.89 303 144148 57323 110387525
Drug hypersensitivity 193.17 9.89 185 144266 453905 109990943
Dyslalia 190.79 9.89 71 144380 1326 110443522
Herpes zoster 190.71 9.89 431 144020 107948 110336900
Anti-cyclic citrullinated peptide antibody positive 190.05 9.89 12 144439 181972 110262876
Wound 187.10 9.89 39 144412 234398 110210450
Drug abuse 181.45 9.89 13 144438 177398 110267450
COVID-19 175.44 9.89 709 143742 244351 110200497
Arthropathy 172.15 9.89 80 144371 287442 110157406
Septic shock 171.00 9.89 523 143928 157005 110287843
Completed suicide 170.91 9.89 52 144399 242329 110202519
Muscle injury 168.69 9.89 3 144448 140804 110304044
Eosinophilia 164.78 9.89 282 144169 57654 110387194
Swelling 163.78 9.89 131 144320 350910 110093938
Dysarthria 162.11 9.89 347 144104 83774 110361074
Dermatitis exfoliative generalised 160.11 9.89 125 144326 10847 110434001
Drug ineffective 156.42 9.89 1256 143195 1519284 108925564
Oral herpes 149.52 9.89 209 144242 35871 110408977
Tumour lysis syndrome 146.81 9.89 191 144260 30610 110414238
Impaired healing 142.71 9.89 40 144411 196677 110248171
Therapeutic product effect decreased 141.63 9.89 71 144380 244245 110200603
Rheumatoid factor positive 139.50 9.89 8 144443 131632 110313216
Pneumonia 138.14 9.89 1749 142702 874965 109569883
Alopecia 132.61 9.89 169 144282 364584 110080264
Lymphopenia 131.03 9.89 208 144243 39962 110404886
Mobility decreased 130.28 9.89 74 144377 237348 110207500
Irritable bowel syndrome 129.61 9.89 28 144423 164187 110280661
Fibromyalgia 129.21 9.89 32 144419 170877 110273971
Type 2 diabetes mellitus 128.63 9.89 36 144415 177196 110267652
Neuropathy peripheral 128.50 9.89 519 143932 178758 110266090
Herpes simplex 128.34 9.89 129 144322 15635 110429213
Nervous system disorder 127.37 9.89 181 144270 31540 110413308
Platelet count decreased 124.33 9.89 613 143838 229830 110215018
Bronchopulmonary aspergillosis 123.76 9.89 173 144278 29690 110415158
Folliculitis 119.93 9.89 35 144416 167618 110277230
Rheumatoid arthritis 119.43 9.89 129 144322 299484 110145364
Intentional overdose 119.06 9.89 16 144435 132485 110312363
Acute myeloid leukaemia 114.34 9.89 190 144261 37920 110406928
Facet joint syndrome 112.31 9.89 3 144448 96825 110348023
Aplastic anaemia 111.61 9.89 148 144303 24160 110420688
Psoriatic arthropathy 109.86 9.89 60 144391 196701 110248147
Abdominal discomfort 108.72 9.89 219 144232 393639 110051209
Musculoskeletal stiffness 107.66 9.89 124 144327 279698 110165150
Obesity 105.97 9.89 12 144439 113339 110331509
C-reactive protein abnormal 104.64 9.89 21 144430 129674 110315174
Toxicity to various agents 104.38 9.89 303 144148 480252 109964596
Joint range of motion decreased 104.19 9.89 17 144434 121815 110323033
Escherichia bacteraemia 103.29 9.89 94 144357 10070 110434778
Ophthalmic herpes simplex 101.67 9.89 40 144411 874 110443974
Hepatic enzyme increased 101.48 9.89 164 144287 320728 110124120
Bursitis 98.83 9.89 24 144427 129894 110314954
Mucosal inflammation 96.73 9.89 311 144140 95830 110349018
Pathogen resistance 96.01 9.89 117 144334 17555 110427293
Osteoarthritis 95.84 9.89 60 144391 182563 110262285
White blood cell count decreased 95.80 9.89 569 143882 228821 110216027
Blood cholesterol increased 95.21 9.89 62 144389 184723 110260125
Cytopenia 94.20 9.89 153 144298 29963 110414885
Neutrophil count decreased 93.00 9.89 358 144093 120583 110324265
Lip dry 92.55 9.89 11 144440 100072 110344776
Squamous cell carcinoma of skin 92.02 9.89 113 144338 17090 110427758
Aplasia 90.34 9.89 78 144373 7795 110437053
Herpes virus infection 89.96 9.89 81 144370 8557 110436291
Pericarditis 89.92 9.89 92 144359 219022 110225826
Pain 89.62 9.89 807 143644 954148 109490700
Maternal exposure during pregnancy 89.61 9.89 121 144330 254762 110190086
Treatment failure 88.30 9.89 141 144310 277093 110167755
Hypersensitivity 86.78 9.89 256 144195 403742 110041106
COVID-19 pneumonia 84.31 9.89 164 144287 36979 110407869
Therapeutic product effect incomplete 84.12 9.89 101 144350 223704 110221144
Microsporidia infection 81.15 9.89 39 144412 1400 110443448
Chronic lymphocytic leukaemia 78.55 9.89 64 144387 5904 110438944
Dry mouth 77.55 9.89 88 144363 199860 110244988
Mixed liver injury 77.33 9.89 87 144364 11992 110432856
Graft versus host disease 76.52 9.89 108 144343 18698 110426150
Grip strength decreased 76.18 9.89 8 144443 80166 110364682
Peripheral venous disease 75.94 9.89 10 144441 84107 110360741
Hallucination 75.33 9.89 297 144154 101135 110343713
Gastrointestinal disorder 75.22 9.89 125 144326 241827 110203021
Hypercholesterolaemia 74.77 9.89 14 144437 90823 110354025
Hallucination, visual 74.70 9.89 162 144289 39443 110405405
Thrombotic microangiopathy 73.98 9.89 135 144316 29014 110415834
Hypogammaglobulinaemia 73.97 9.89 110 144341 19966 110424882
Musculoskeletal pain 72.68 9.89 79 144372 182944 110261904
Rhinovirus infection 72.23 9.89 83 144368 11706 110433142
Blister 72.06 9.89 116 144335 227260 110217588
Suicide attempt 69.63 9.89 24 144427 103370 110341478
Wheezing 68.62 9.89 144 144307 255086 110189762
Bacteraemia 68.40 9.89 163 144288 42227 110402621
Pseudomonas infection 68.18 9.89 127 144324 27726 110417122
Injury 65.55 9.89 81 144370 177184 110267664
Sepsis 65.17 9.89 684 143767 326662 110118186
Drug resistance 63.78 9.89 190 144261 56184 110388664
Klebsiella bacteraemia 63.63 9.89 52 144399 4817 110440031
Graft versus host disease in gastrointestinal tract 63.32 9.89 68 144383 8900 110435948
Face oedema 63.24 9.89 137 144314 33332 110411516
Red blood cell sedimentation rate increased 62.49 9.89 13 144438 78289 110366559
Blood creatinine increased 61.76 9.89 430 144021 182459 110262389
Pulmonary fibrosis 61.64 9.89 28 144423 102014 110342834
Ischaemic stroke 61.61 9.89 154 144297 41109 110403739
Cryopyrin associated periodic syndrome 61.36 9.89 25 144426 600 110444248
Peripheral swelling 61.35 9.89 295 144156 403739 110041109
Gait inability 60.94 9.89 53 144398 136323 110308525
Arthralgia 60.54 9.89 689 143762 778943 109665905
Hyperthermia 59.76 9.89 103 144348 21169 110423679
Discomfort 59.52 9.89 119 144332 214588 110230260
Lower limb fracture 59.13 9.89 13 144438 75335 110369513
Bone marrow failure 58.97 9.89 188 144263 57660 110387188
Bacterial sepsis 58.23 9.89 70 144381 10356 110434492
Acute pulmonary oedema 58.19 9.89 90 144361 16906 110427942
Escherichia sepsis 57.42 9.89 69 144382 10203 110434645
Blood urea increased 57.30 9.89 180 144271 54777 110390071
Renal tubular disorder 57.21 9.89 59 144392 7370 110437478
Weight increased 56.09 9.89 320 144131 419324 110025524
Liver injury 55.32 9.89 69 144382 150344 110294504
Laryngitis fungal 55.11 9.89 17 144434 173 110444675
Vocal cord dysfunction 54.34 9.89 26 144425 924 110443924
Human herpesvirus 6 encephalitis 54.25 9.89 27 144424 1047 110443801
Renal failure 54.16 9.89 492 143959 226082 110218766
Pneumocystis jirovecii pneumonia 54.13 9.89 150 144301 42585 110402263
Blepharospasm 53.35 9.89 5 144446 54846 110390002
Aspergillus infection 53.21 9.89 109 144342 25507 110419341
Wound infection 52.98 9.89 30 144421 96435 110348413
Atrial fibrillation 52.54 9.89 494 143957 229148 110215700
Lower respiratory tract infection 52.19 9.89 154 144297 242952 110201896
Haemophagocytic lymphohistiocytosis 51.62 9.89 122 144329 31437 110413411
Hyperuricaemia 51.23 9.89 78 144373 14453 110430395
Sleep disorder 50.96 9.89 115 144336 198529 110246319
Drug interaction 50.20 9.89 415 144036 499768 109945080
Myoclonus 50.16 9.89 124 144327 32874 110411974
Squamous cell carcinoma 50.04 9.89 88 144363 18375 110426473
Cytomegalovirus infection 49.31 9.89 170 144281 54274 110390574
Posterior reversible encephalopathy syndrome 49.12 9.89 125 144326 33736 110411112
Diffuse large B-cell lymphoma 48.68 9.89 80 144371 15818 110429030
Genital herpes 48.36 9.89 34 144417 2513 110442335
Ill-defined disorder 47.85 9.89 82 144369 156771 110288077
Onychomadesis 47.69 9.89 3 144448 45660 110399188
Product use issue 47.64 9.89 227 144224 311468 110133380
Pancreatitis acute 47.61 9.89 180 144271 60094 110384754
Eyelid irritation 47.20 9.89 25 144426 1106 110443742
Streptococcal bacteraemia 47.09 9.89 43 144408 4626 110440222
Disorientation 46.98 9.89 200 144251 70471 110374377
Product tampering 46.48 9.89 19 144432 460 110444388
Antiviral drug level above therapeutic 46.31 9.89 13 144438 92 110444756
Inflammation 46.29 9.89 116 144335 193122 110251726
Hypoglycaemia 46.21 9.89 50 144401 116054 110328794
Rectal prolapse 45.86 9.89 33 144418 2530 110442318
Adjustment disorder with depressed mood 45.48 9.89 3 144448 43880 110400968
Contusion 45.07 9.89 155 144296 233206 110211642
Hepatic cirrhosis 45.01 9.89 16 144435 67610 110377238
Sciatica 44.93 9.89 33 144418 92366 110352482
Laryngeal stenosis 44.88 9.89 26 144425 1372 110443476
Tumour flare 44.70 9.89 27 144424 1540 110443308
Deep vein thrombosis 44.37 9.89 324 144127 139563 110305285
Hypertension 44.30 9.89 439 144012 509645 109935203
Road traffic accident 44.15 9.89 45 144406 107353 110337495
Plasma cell myeloma recurrent 43.86 9.89 50 144401 6992 110437856
Ophthalmic herpes zoster 43.83 9.89 36 144415 3359 110441489
Colitis 43.44 9.89 255 144196 102068 110342780
Demodicidosis 42.97 9.89 15 144436 231 110444617
Purpura 42.88 9.89 97 144354 24291 110420557
Diarrhoea 42.75 9.89 1857 142594 1137648 109307200
Parainfluenzae virus infection 42.56 9.89 49 144402 6925 110437923
Renal disorder 41.80 9.89 151 144300 49328 110395520
Lymphocyte count decreased 41.20 9.89 166 144285 57077 110387771
Hip arthroplasty 41.11 9.89 11 144440 55802 110389046
Serotonin syndrome 41.11 9.89 13 144438 59140 110385708
Pain in extremity 40.74 9.89 423 144028 486695 109958153
Infusion related reaction 40.65 9.89 311 144140 380851 110063997
Depressed level of consciousness 40.28 9.89 268 144183 112010 110332838
Encephalitis cytomegalovirus 39.80 9.89 27 144424 1883 110442965
Nail disorder 39.79 9.89 13 144438 57922 110386926
Product quality issue 39.71 9.89 26 144425 77273 110367575
Coeliac disease 39.30 9.89 5 144446 43182 110401666
Bladder prolapse 38.96 9.89 24 144427 1418 110443430
Drug dependence 38.51 9.89 9 144442 50011 110394837
Incorrect route of product administration 38.03 9.89 18 144433 64043 110380805
Alpha haemolytic streptococcal infection 38.03 9.89 34 144417 3559 110441289
Sedation 37.80 9.89 22 144429 69661 110375187
Knee arthroplasty 37.42 9.89 19 144432 64929 110379919
Nephropathy toxic 37.35 9.89 99 144352 27379 110417469
Pneumonia fungal 37.02 9.89 68 144383 14686 110430162
Dermatitis atopic 36.75 9.89 94 144357 25447 110419401
Night sweats 36.49 9.89 75 144376 133908 110310940
Foreign body in reproductive tract 36.37 9.89 20 144431 954 110443894
Psychiatric symptom 36.14 9.89 52 144399 9161 110435687
General physical health deterioration 36.09 9.89 368 144083 424927 110019921
International normalised ratio increased 36.07 9.89 36 144415 86736 110358112
Depression 35.71 9.89 255 144196 317080 110127768
Herpes ophthalmic 35.69 9.89 25 144426 1837 110443011
Hyperleukocytosis 35.33 9.89 32 144419 3407 110441441
Crystalluria 35.21 9.89 22 144429 1333 110443515
Injection site inflammation 35.14 9.89 37 144414 4734 110440114
Encephalitis 34.32 9.89 76 144375 18763 110426085
Subretinal haematoma 34.23 9.89 9 144442 48 110444800
Skin lesion 34.23 9.89 146 144305 51485 110393363
Lupus-like syndrome 34.19 9.89 6 144445 40786 110404062
Exostosis 33.96 9.89 9 144442 45947 110398901
Arthritis 33.94 9.89 109 144342 167477 110277371
Gastrooesophageal reflux disease 33.11 9.89 122 144329 179854 110264994
Renal impairment 32.98 9.89 384 144067 188061 110256787
Loss of personal independence in daily activities 32.94 9.89 94 144357 149926 110294922
Cheilitis 32.74 9.89 41 144410 6324 110438524
Dyspnoea 32.41 9.89 1152 143299 1105720 109339128
Clostridium difficile colitis 32.34 9.89 128 144323 43650 110401198
Finger deformity 32.23 9.89 3 144448 33089 110411759
Respiratory tract infection viral 32.07 9.89 39 144412 5839 110439009
Dermatitis exfoliative 31.95 9.89 55 144396 11292 110433556
Speech disorder 31.90 9.89 162 144289 61407 110383441
Asthma 31.74 9.89 194 144257 250097 110194751
Bradycardia 30.90 9.89 102 144349 155415 110289433
SARS-CoV-2 sepsis 30.90 9.89 12 144439 253 110444595
Blood lactate dehydrogenase increased 30.66 9.89 127 144324 44207 110400641
Anaemia 30.58 9.89 933 143518 546153 109898695
Viral mutation identified 30.31 9.89 33 144418 4386 110440462
Peripheral sensory neuropathy 30.06 9.89 67 144384 16613 110428235
Respiratory tract infection bacterial 29.90 9.89 25 144426 2391 110442457
Claustrophobia 29.80 9.89 21 144430 1558 110443290
Autoimmune disorder 29.80 9.89 25 144426 65458 110379390
Fear of disease 29.74 9.89 20 144431 1375 110443473
Abdominal pain upper 29.64 9.89 302 144149 348809 110096039
Venoocclusive liver disease 29.59 9.89 63 144388 15144 110429704
Varicella zoster virus infection 29.58 9.89 39 144412 6329 110438519
Prescribed underdose 29.51 9.89 25 144426 65149 110379699
Cholestatic liver injury 29.48 9.89 42 144409 7334 110437514
Increased viscosity of upper respiratory secretion 29.32 9.89 15 144436 617 110444231
Sopor 29.30 9.89 6 144445 36540 110408308
Liver function test increased 29.15 9.89 44 144407 88504 110356344
Leukopenia 29.14 9.89 310 144141 148481 110296367
Pneumonia influenzal 28.91 9.89 30 144421 3775 110441073
Pseudomonal bacteraemia 28.87 9.89 32 144419 4339 110440509
Differentiation syndrome 28.70 9.89 27 144424 3017 110441831
Live birth 28.69 9.89 29 144422 69455 110375393
Exposure during pregnancy 28.54 9.89 117 144334 167307 110277541
Pneumonia parainfluenzae viral 28.27 9.89 15 144436 666 110444182
Rhabdomyolysis 28.27 9.89 73 144378 120328 110324520
Laryngeal inflammation 28.11 9.89 12 144439 325 110444523
Myelodysplastic syndrome 28.01 9.89 110 144341 37374 110407474
Cerebral toxoplasmosis 27.97 9.89 27 144424 3115 110441733
Cardiac failure 27.96 9.89 371 144080 187255 110257593
Bicytopenia 27.93 9.89 39 144412 6685 110438163
Hepatitis cholestatic 27.75 9.89 67 144384 17499 110427349
Gamma-glutamyltransferase increased 27.46 9.89 155 144296 61154 110383694
X-ray abnormal 27.17 9.89 8 144443 38109 110406739
Interstitial lung disease 27.15 9.89 290 144161 139044 110305804
Cerebellar stroke 27.08 9.89 16 144435 876 110443972
Facial paralysis 26.81 9.89 81 144370 24133 110420715
Nephritis allergic 26.74 9.89 17 144434 1062 110443786
Mucormycosis 26.69 9.89 49 144402 10579 110434269
Oedema 26.49 9.89 163 144288 209813 110235035
Graft versus host disease in lung 26.47 9.89 18 144433 1260 110443588
Incorrect dosage administered 26.42 9.89 29 144422 3889 110440959
Intentional self-injury 26.41 9.89 8 144443 37421 110407427
Haematochezia 26.39 9.89 71 144380 115453 110329395
Confusional state 26.37 9.89 800 143651 467880 109976968
Tender joint count decreased 26.18 9.89 11 144440 286 110444562
Conjunctival irritation 26.00 9.89 9 144442 135 110444713
Somatic symptom disorder 25.99 9.89 26 144425 3133 110441715
Immunoglobulins decreased 25.98 9.89 23 144428 2376 110442472
Fluid replacement 25.80 9.89 16 144435 957 110443891
Acute febrile neutrophilic dermatosis 25.72 9.89 32 144419 4904 110439944
Adulterated product 25.68 9.89 17 144434 1138 110443710
Staphylococcal bacteraemia 25.67 9.89 63 144388 16625 110428223
Back injury 25.66 9.89 15 144436 47384 110397464
CSF cell count increased 25.53 9.89 9 144442 143 110444705
Acute respiratory distress syndrome 25.50 9.89 137 144314 53061 110391787
Progressive multifocal leukoencephalopathy 25.33 9.89 81 144370 24875 110419973
Foot deformity 25.32 9.89 16 144435 48464 110396384
Neutropenic colitis 25.25 9.89 41 144410 8024 110436824
Intentional product misuse 25.16 9.89 89 144362 132815 110312033
Central nervous system necrosis 24.86 9.89 12 144439 435 110444413
Escherichia infection 24.82 9.89 78 144373 23738 110421110
Malaise 24.77 9.89 678 143773 671141 109773707
Cell death 24.67 9.89 34 144417 5757 110439091
Polymyositis 24.24 9.89 27 144424 3681 110441167
Influenza 24.22 9.89 332 144119 168769 110276079
Allogenic stem cell transplantation 24.20 9.89 10 144441 249 110444599
Device related infection 24.10 9.89 109 144342 39410 110405438
Metabolic encephalopathy 24.09 9.89 48 144403 11012 110433836
Eye infection toxoplasmal 24.04 9.89 14 144437 746 110444102
Cerebellar syndrome 23.89 9.89 35 144416 6267 110438581
Hepatitis acute 23.89 9.89 66 144385 18700 110426148
Bronchopneumopathy 23.87 9.89 15 144436 918 110443930
Swollen joint count decreased 23.77 9.89 11 144440 362 110444486
Condition aggravated 23.75 9.89 755 143696 734081 109710767
Underdose 23.52 9.89 29 144422 63525 110381323
Eosinophilic colitis 23.45 9.89 13 144438 630 110444218
Cryptosporidiosis infection 23.44 9.89 16 144435 1127 110443721
Post herpetic neuralgia 23.25 9.89 25 144426 3276 110441572
Acute lymphocytic leukaemia recurrent 23.20 9.89 33 144418 5754 110439094
Vaccination failure 23.19 9.89 22 144429 2484 110442364
Fusarium infection 23.15 9.89 23 144428 2748 110442100
Joint dislocation 22.91 9.89 8 144443 34182 110410666
Genital herpes simplex 22.88 9.89 12 144439 520 110444328
Wrong technique in product usage process 22.86 9.89 50 144401 87298 110357550
Retinal detachment 22.78 9.89 47 144404 11053 110433795
Basal cell carcinoma 22.67 9.89 118 144333 45152 110399696
Pregnancy 22.62 9.89 20 144431 51047 110393801
Mucosal excoriation 22.57 9.89 4 144447 0 110444848
Ichthyosis 22.53 9.89 9 144442 205 110444643
Metastases to liver 22.50 9.89 9 144442 35377 110409471
Amyotrophy 22.46 9.89 13 144438 685 110444163
Herpes zoster oticus 22.42 9.89 13 144438 687 110444161
Eye infection bacterial 22.28 9.89 11 144440 419 110444429
Haemolytic anaemia 22.25 9.89 69 144382 20851 110423997
Staphylococcal infection 22.17 9.89 162 144289 69782 110375066
Chills 22.16 9.89 361 144090 190219 110254629
Epstein-Barr virus infection 22.00 9.89 64 144387 18674 110426174
Rectal abscess 21.83 9.89 22 144429 2674 110442174
Cutaneous vasculitis 21.68 9.89 50 144401 12679 110432169
Salmonellosis 21.44 9.89 20 144431 2211 110442637
Prescribed overdose 21.41 9.89 52 144399 87529 110357319
Genital erythema 21.31 9.89 10 144441 340 110444508
Plasma cell myeloma refractory 21.30 9.89 19 144432 1982 110442866
Aphasia 21.26 9.89 141 144310 58856 110385992
Enteritis 21.13 9.89 64 144387 19092 110425756
Onychomycosis 21.13 9.89 12 144439 38519 110406329
Malignant neoplasm of unknown primary site 21.11 9.89 13 144438 768 110444080
Medication error 21.00 9.89 69 144382 105297 110339551
Cytomegalovirus test positive 20.99 9.89 35 144416 7001 110437847
Retinitis 20.92 9.89 8 144443 32319 110412529
Hypoaesthesia 20.82 9.89 287 144164 313936 110130912
Intentional product use issue 20.81 9.89 215 144236 247691 110197157
Cardiac arrest 20.74 9.89 161 144290 196592 110248256
Dyspepsia 20.72 9.89 155 144296 190810 110254038
Nocardiosis 20.70 9.89 36 144415 7450 110437398
Full blood count decreased 20.68 9.89 90 144361 32009 110412839
Drug withdrawal syndrome 20.66 9.89 12 144439 38042 110406806
Disseminated mucormycosis 20.50 9.89 19 144432 2083 110442765
Serum sickness 20.49 9.89 27 144424 4379 110440469
Angina pectoris 20.46 9.89 31 144420 62264 110382584
Acute lymphocytic leukaemia 20.40 9.89 31 144420 5734 110439114
Pulse abnormal 20.19 9.89 26 144425 4123 110440725
Klebsiella sepsis 20.17 9.89 26 144425 4127 110440721
Ectropion 20.12 9.89 11 144440 519 110444329
Taste disorder 20.10 9.89 34 144417 65353 110379495
Complication of device insertion 20.03 9.89 39 144412 8799 110436049
Pneumonia haemophilus 19.90 9.89 21 144430 2694 110442154
Nasopharyngitis 19.88 9.89 379 144072 393982 110050866
Toxic erythema of chemotherapy 19.76 9.89 10 144441 402 110444446
Lichenoid keratosis 19.68 9.89 32 144419 6270 110438578
Torsade de pointes 19.66 9.89 3 144448 22597 110422251
Peripheral T-cell lymphoma unspecified 19.54 9.89 13 144438 878 110443970
Optic neuropathy 19.32 9.89 27 144424 4631 110440217
Pulmonary sarcoidosis 19.21 9.89 17 144434 1755 110443093
Tractional retinal detachment 19.15 9.89 7 144444 124 110444724
Acute HIV infection 19.11 9.89 6 144445 65 110444783
Lymphocytosis 19.01 9.89 29 144422 5382 110439466
Haemorrhoids thrombosed 18.99 9.89 9 144442 313 110444535
SAPHO syndrome 18.93 9.89 11 144440 584 110444264
Axonal neuropathy 18.92 9.89 19 144432 2299 110442549
Dermatitis bullous 18.81 9.89 58 144393 17471 110427377
Fall 18.78 9.89 623 143828 602859 109841989
Infective exacerbation of chronic obstructive airways disease 18.77 9.89 22 144429 3168 110441680
Chest pain 18.58 9.89 363 144088 376012 110068836
Adverse event 18.57 9.89 76 144375 108733 110336115
Campylobacter test positive 18.55 9.89 7 144444 136 110444712
Intensive care 18.51 9.89 19 144432 2360 110442488
Respiratory syncytial virus infection 18.50 9.89 51 144400 14433 110430415
Epilepsy 18.38 9.89 68 144383 100141 110344707
Hyperbilirubinaemia 18.26 9.89 84 144367 30587 110414261
Keratitis bacterial 18.20 9.89 8 144443 233 110444615
Cytomegalovirus infection reactivation 18.15 9.89 59 144392 18274 110426574
Bone marrow transplant 18.15 9.89 16 144435 1644 110443204
Enterococcal sepsis 18.11 9.89 22 144429 3290 110441558
Lichenification 18.07 9.89 13 144438 996 110443852
Post transplant lymphoproliferative disorder 18.02 9.89 53 144398 15560 110429288
Device related bacteraemia 17.92 9.89 14 144437 1216 110443632
Fungal endocarditis 17.86 9.89 12 144439 824 110444024
Embedded device 17.66 9.89 24 144427 4009 110440839
Pulmonary embolism 17.59 9.89 385 144066 214089 110230759
Anaphylactic reaction 17.58 9.89 83 144368 114217 110330631
Conjunctivitis 17.56 9.89 89 144362 33703 110411145
Jugular vein occlusion 17.52 9.89 6 144445 87 110444761
Glomerulosclerosis 17.45 9.89 14 144437 1263 110443585
Herpes zoster meningoencephalitis 17.30 9.89 13 144438 1065 110443783
Rectal haemorrhage 17.29 9.89 89 144362 119744 110325104
SARS-CoV-2 test positive 17.22 9.89 55 144396 16880 110427968
Rhegmatogenous retinal detachment 17.21 9.89 8 144443 266 110444582
Coronary artery disease 17.18 9.89 43 144408 71647 110373201
Urine output decreased 17.08 9.89 61 144390 19815 110425033
Lactic acidosis 17.00 9.89 63 144388 92748 110352100
Malignant neoplasm progression 16.95 9.89 146 144305 174421 110270427
Metastases to bone 16.88 9.89 10 144441 31362 110413486
Venoocclusive disease 16.87 9.89 30 144421 6320 110438528
Ataxia 16.86 9.89 81 144370 30027 110414821
Gamma-glutamyltransferase abnormal 16.73 9.89 12 144439 915 110443933
Rash morbilliform 16.71 9.89 34 144417 7917 110436931
Myelosuppression 16.66 9.89 65 144386 94275 110350573
Acute coronary syndrome 16.61 9.89 67 144384 23045 110421803
Aphthous ulcer 16.59 9.89 63 144388 21073 110423775
Serum amyloid A protein increased 16.56 9.89 12 144439 930 110443918
Macrocytosis 16.53 9.89 21 144430 3286 110441562
Restlessness 16.53 9.89 128 144323 56131 110388717
Bone hypertrophy 16.49 9.89 11 144440 746 110444102
Donor leukocyte infusion 16.47 9.89 5 144446 48 110444800
Myasthenia gravis 16.30 9.89 4 144447 21507 110423341
Laryngeal cancer metastatic 16.29 9.89 5 144446 50 110444798
Labelled drug-drug interaction medication error 16.25 9.89 9 144442 29293 110415555
Blood uric acid abnormal 16.22 9.89 9 144442 437 110444411
Rash pustular 16.21 9.89 45 144406 12784 110432064
Disease recurrence 16.07 9.89 135 144316 60649 110384199
Pneumonia viral 15.99 9.89 41 144410 11116 110433732
Ulcerative keratitis 15.98 9.89 25 144426 4741 110440107
Bronchiolitis 15.96 9.89 27 144424 5466 110439382
Urinary tract infection pseudomonal 15.95 9.89 17 144434 2205 110442643
HCoV-OC43 infection 15.94 9.89 5 144446 54 110444794
Mantle cell lymphoma 15.94 9.89 15 144436 1677 110443171
Oesophagitis 15.90 9.89 77 144374 28638 110416210
Peripheral T-cell lymphoma unspecified recurrent 15.86 9.89 5 144446 55 110444793
Limbic encephalitis 15.84 9.89 11 144440 797 110444051
Respiratory tract infection 15.83 9.89 153 144298 71464 110373384
Enterococcal bacteraemia 15.80 9.89 24 144427 4437 110440411
Herpes simplex reactivation 15.75 9.89 14 144437 1454 110443394
Meningitis 15.74 9.89 42 144409 11660 110433188
Lymphoma 15.73 9.89 60 144391 20111 110424737
Polyneuropathy 15.73 9.89 83 144368 31929 110412919
Mantle cell lymphoma recurrent 15.65 9.89 12 144439 1014 110443834
Drug ineffective for unapproved indication 15.63 9.89 75 144376 102763 110342085
Ulcer haemorrhage 15.61 9.89 5 144446 22566 110422282
Migraine 15.60 9.89 146 144305 171506 110273342
Urticaria 15.59 9.89 308 144143 318549 110126299
Pleural effusion 15.54 9.89 322 144129 177387 110267461
Plasmacytoma 15.47 9.89 26 144425 5236 110439612
Muscle rigidity 15.46 9.89 6 144445 24025 110420823
Device malfunction 15.45 9.89 7 144444 25551 110419297
Disseminated varicella zoster virus infection 15.33 9.89 13 144438 1268 110443580
Cyanosis 15.28 9.89 10 144441 29731 110415117
Neurological symptom 15.25 9.89 50 144401 15558 110429290
Portal vein cavernous transformation 15.21 9.89 6 144445 132 110444716
Fungaemia 15.21 9.89 28 144423 6058 110438790
Atypical haemolytic uraemic syndrome 15.17 9.89 14 144437 1526 110443322
Liver disorder 15.17 9.89 116 144335 142127 110302721
Complication of device removal 15.17 9.89 24 144427 4596 110440252
Respiratory distress 15.16 9.89 147 144304 68727 110376121
Brief psychotic disorder with marked stressors 15.14 9.89 8 144443 352 110444496
Blood glucose increased 15.12 9.89 106 144345 132390 110312458
Mycobacterium tuberculosis complex test positive 15.06 9.89 20 144431 3268 110441580
Hypophagia 15.06 9.89 119 144332 52507 110392341
Erythema multiforme 15.03 9.89 61 144390 21036 110423812
Haemophilus bacteraemia 15.03 9.89 7 144444 234 110444614
Adrenal insufficiency 15.01 9.89 20 144431 42370 110402478
Periorbital cellulitis 14.98 9.89 12 144439 1080 110443768
Meningoencephalitis amoebic 14.95 9.89 7 144444 237 110444611
Blood immunoglobulin G abnormal 14.92 9.89 6 144445 139 110444709
Neurocryptococcosis 14.89 9.89 5 144446 68 110444780
Meningoencephalitis herpetic 14.87 9.89 17 144434 2385 110442463
Embolism 14.87 9.89 51 144400 16238 110428610
Joint stiffness 14.85 9.89 42 144409 67201 110377647
Bone pain 14.82 9.89 140 144311 64993 110379855
Frequent bowel movements 14.75 9.89 46 144405 71344 110373504
Actinic keratosis 14.75 9.89 30 144421 6983 110437865
Poisoning deliberate 14.73 9.89 8 144443 26323 110418525
Aeromonas infection 14.67 9.89 9 144442 528 110444320
Citrobacter infection 14.64 9.89 13 144438 1349 110443499
Neutropenic sepsis 14.62 9.89 79 144372 30667 110414181
Blood immunoglobulin M abnormal 14.57 9.89 6 144445 148 110444700
Arterial intramural haematoma 14.57 9.89 7 144444 251 110444597
Morganella infection 14.50 9.89 13 144438 1366 110443482
Photosensitivity reaction 14.44 9.89 69 144382 25520 110419328
Lymphadenopathy 14.42 9.89 137 144314 63698 110381150
Pneumonia pseudomonal 14.38 9.89 31 144420 7515 110437333
Bacterial vaginosis 14.31 9.89 13 144438 1389 110443459
Infective chondritis 14.29 9.89 4 144447 28 110444820
Campylobacter gastroenteritis 14.28 9.89 15 144436 1914 110442934
Biopsy skin abnormal 14.22 9.89 7 144444 265 110444583
Mesenteric artery thrombosis 14.21 9.89 11 144440 942 110443906
Epstein-Barr virus associated lymphoma 14.21 9.89 14 144437 1656 110443192
Corneal perforation 14.18 9.89 11 144440 945 110443903
Eye pain 14.18 9.89 113 144338 49986 110394862
Platelet transfusion 14.11 9.89 18 144433 2828 110442020
Pulmonary sepsis 14.10 9.89 25 144426 5253 110439595
Memory impairment 14.09 9.89 177 144274 196767 110248081
Botryomycosis 14.04 9.89 5 144446 82 110444766
Cellulitis 14.01 9.89 237 144214 125779 110319069
Corneal thinning 14.01 9.89 7 144444 274 110444574
Acute polyneuropathy 14.00 9.89 10 144441 758 110444090
Generalised oedema 14.00 9.89 78 144373 30626 110414222
Delirium 13.96 9.89 251 144200 134774 110310074
Toxic epidermal necrolysis 13.95 9.89 124 144327 56603 110388245
Alexithymia 13.93 9.89 4 144447 31 110444817
Sudden death 13.93 9.89 66 144385 24329 110420519
Off label use 13.92 9.89 2196 142255 1497989 108946859
Logorrhoea 13.92 9.89 24 144427 4933 110439915
Jugular vein thrombosis 13.87 9.89 25 144426 5320 110439528
Disease progression 13.82 9.89 417 144034 243617 110201231
Herpes zoster reactivation 13.81 9.89 8 144443 422 110444426
Therapy non-responder 13.79 9.89 135 144316 157172 110287676
Haematemesis 13.75 9.89 36 144415 59072 110385776
Mixed dementia 13.73 9.89 7 144444 286 110444562
Pseudolymphoma 13.69 9.89 12 144439 1223 110443625
Enterobacter pneumonia 13.68 9.89 9 144442 596 110444252
Hypocalcaemia 13.65 9.89 138 144313 65228 110379620
Conjunctivitis viral 13.64 9.89 7 144444 290 110444558
Respiratory depression 13.62 9.89 13 144438 31988 110412860
Neurosis 13.62 9.89 9 144442 601 110444247
Malnutrition 13.59 9.89 71 144380 27208 110417640
Osteoporosis 13.57 9.89 63 144388 87089 110357759
Gingival ulceration 13.57 9.89 12 144439 1238 110443610
Pneumonia klebsiella 13.51 9.89 28 144423 6604 110438244
Weight fluctuation 13.49 9.89 6 144445 22139 110422709
Disseminated cryptococcosis 13.48 9.89 17 144434 2640 110442208
Thrombotic thrombocytopenic purpura 13.31 9.89 29 144422 7082 110437766
Acute myeloid leukaemia recurrent 13.29 9.89 24 144427 5115 110439733
Pneumocystis jirovecii infection 13.28 9.89 22 144429 4378 110440470
Cytomegalovirus chorioretinitis 13.26 9.89 29 144422 7099 110437749
Disability 13.19 9.89 12 144439 30211 110414637
Stem cell transplant 13.18 9.89 22 144429 4405 110440443
Extrapyramidal disorder 13.16 9.89 11 144440 28856 110415992
Blood creatine phosphokinase increased 13.13 9.89 50 144401 73027 110371821
Cutaneous T-cell lymphoma 13.13 9.89 19 144432 3365 110441483
Complications of transplanted heart 13.12 9.89 8 144443 464 110444384
Melaena 13.04 9.89 46 144405 68711 110376137
Lymphocytic lymphoma 13.03 9.89 5 144446 102 110444746
Pneumonia respiratory syncytial viral 13.02 9.89 17 144434 2732 110442116
Varicella 13.02 9.89 20 144431 3735 110441113
Metastases to lung 12.91 9.89 7 144444 23056 110421792
Necrotising retinitis 12.88 9.89 13 144438 1583 110443265
Herpes simplex viraemia 12.86 9.89 9 144442 660 110444188
Urea renal clearance decreased 12.85 9.89 4 144447 42 110444806
Meningitis aseptic 12.85 9.89 35 144416 9835 110435013
Persistent corneal epithelial defect 12.85 9.89 5 144446 106 110444742
Mutism 12.85 9.89 18 144433 3095 110441753
Flushing 12.85 9.89 82 144369 104654 110340194
Fungal disease carrier 12.82 9.89 8 144443 484 110444364
Monocyte morphology abnormal 12.78 9.89 3 144448 9 110444839
Pseudomonal sepsis 12.71 9.89 33 144418 9013 110435835
Female genital tract fistula 12.66 9.89 3 144448 16516 110428332
Campylobacter colitis 12.63 9.89 5 144446 111 110444737
Toxic neuropathy 12.63 9.89 11 144440 1112 110443736
Congestive cardiomyopathy 12.53 9.89 44 144407 14175 110430673
Graft versus host disease in skin 12.52 9.89 31 144420 8223 110436625
Body temperature decreased 12.50 9.89 18 144433 36917 110407931
Anxiety 12.50 9.89 349 144102 344729 110100119
Neuralgia 12.46 9.89 107 144344 48371 110396477
Gangrene 12.46 9.89 3 144448 16338 110428510
Neuropsychiatric syndrome 12.44 9.89 6 144445 217 110444631
Breath sounds abnormal 12.44 9.89 9 144442 25395 110419453
Constipation 12.43 9.89 579 143872 357207 110087641
Erythrosis 12.39 9.89 6 144445 219 110444629
Blood immunoglobulin E increased 12.32 9.89 29 144422 7453 110437395
Poriomania 12.32 9.89 6 144445 222 110444626
Terminal ileitis 12.30 9.89 13 144438 1671 110443177
Subacute combined cord degeneration 12.23 9.89 7 144444 361 110444487
Ventricular fibrillation 12.23 9.89 22 144429 41291 110403557
Cerebral venous thrombosis 12.20 9.89 18 144433 3244 110441604
Therapeutic product ineffective 12.18 9.89 16 144435 2588 110442260
Soft tissue infection 12.14 9.89 23 144428 5084 110439764
Foetal death 12.13 9.89 3 144448 16042 110428806
Pharyngeal inflammation 12.11 9.89 13 144438 1701 110443147
Wrong strength 12.10 9.89 6 144445 231 110444617
Anal infection 12.10 9.89 6 144445 231 110444617
Neutrophil morphology abnormal 12.05 9.89 5 144446 126 110444722
Systemic inflammatory response syndrome 12.05 9.89 41 144410 13002 110431846
Atrial flutter 11.98 9.89 63 144388 24199 110420649
Lymphocytic infiltration 11.98 9.89 14 144437 2011 110442837
Nodule 11.96 9.89 15 144436 32616 110412232
Platelet disorder 11.94 9.89 19 144432 3656 110441192
Metastatic squamous cell carcinoma 11.93 9.89 9 144442 742 110444106
Venous thrombosis 11.92 9.89 31 144420 8474 110436374
Imperception 11.92 9.89 3 144448 13 110444835
Anuria 11.88 9.89 63 144388 24278 110420570
Fracture 11.86 9.89 9 144442 24779 110420069
Arteriosclerosis 11.84 9.89 9 144442 24758 110420090
Myocardial infarction 11.82 9.89 178 144273 191905 110252943
Hepatitis fulminant 11.80 9.89 31 144420 8529 110436319
Vitiligo 11.79 9.89 17 144434 3000 110441848
Respiratory arrest 11.74 9.89 38 144413 58261 110386587
Cholecystitis chronic 11.69 9.89 33 144418 9467 110435381
Inappropriate antidiuretic hormone secretion 11.66 9.89 80 144371 33771 110411077
Varicella virus test positive 11.66 9.89 7 144444 395 110444453
Myositis 11.60 9.89 75 144376 31041 110413807
Cytomegalovirus viraemia 11.59 9.89 50 144401 17714 110427134
Cardiomyopathy acute 11.59 9.89 7 144444 399 110444449
Pneumonia bacterial 11.50 9.89 66 144385 26195 110418653
Melanaemia 11.50 9.89 4 144447 61 110444787
CSF volume increased 11.50 9.89 4 144447 61 110444787
Dyscalculia 11.49 9.89 5 144446 142 110444706
Bacillus bacteraemia 11.46 9.89 6 144445 259 110444589
Adenovirus infection 11.45 9.89 36 144415 10958 110433890
Tri-iodothyronine free increased 11.44 9.89 6 144445 260 110444588
Intracranial pressure increased 11.44 9.89 35 144416 10500 110434348
Cerebral thrombosis 11.38 9.89 15 144436 2433 110442415
Adenocarcinoma of colon 11.37 9.89 25 144426 6143 110438705
Pneumonia pneumococcal 11.36 9.89 22 144429 4943 110439905
Leukaemia recurrent 11.31 9.89 17 144434 3114 110441734
Rash 11.29 9.89 1231 143220 819733 109625115
Crystal nephropathy 11.26 9.89 13 144438 1843 110443005
Food allergy 11.25 9.89 6 144445 19942 110424906
Benign neoplasm of skin 11.24 9.89 5 144446 150 110444698
Cytomegalovirus colitis 11.23 9.89 27 144424 7034 110437814
Pityriasis rubra pilaris 11.21 9.89 6 144445 271 110444577
Gingival erosion 11.21 9.89 5 144446 151 110444697
Suspected suicide 11.19 9.89 3 144448 15196 110429652
Chronic obstructive pulmonary disease 11.18 9.89 90 144361 109068 110335780
Device occlusion 11.17 9.89 3 144448 15182 110429666
SJS-TEN overlap 11.16 9.89 13 144438 1861 110442987
Neuroendocrine carcinoma 11.13 9.89 9 144442 821 110444027
Acanthamoeba infection 11.10 9.89 8 144443 615 110444233
Opportunistic infection 11.08 9.89 18 144433 3525 110441323
Poisoning 11.07 9.89 13 144438 29092 110415756
Incorrect disposal of product 11.05 9.89 11 144440 1317 110443531
Glossoptosis 11.05 9.89 6 144445 279 110444569
T-cell prolymphocytic leukaemia 11.04 9.89 4 144447 69 110444779
Drug monitoring procedure not performed 11.04 9.89 11 144440 1319 110443529
Optic atrophy 11.04 9.89 15 144436 2506 110442342
Insomnia 11.02 9.89 373 144078 360217 110084631
Sinusitis 11.01 9.89 299 144152 296389 110148459
Blood creatinine abnormal 10.99 9.89 24 144427 5868 110438980
Stenotrophomonas bacteraemia 10.95 9.89 6 144445 284 110444564
Vitamin D decreased 10.93 9.89 38 144413 12177 110432671
Salmonella bacteraemia 10.93 9.89 8 144443 630 110444218
Product administration interrupted 10.87 9.89 36 144415 11256 110433592
Intraductal papillary mucinous neoplasm 10.86 9.89 9 144442 850 110443998
Colitis ulcerative 10.86 9.89 58 144393 77305 110367543
Erythropoiesis abnormal 10.85 9.89 8 144443 637 110444211
Hyperreflexia 10.76 9.89 32 144419 9453 110435395
Granulicatella infection 10.74 9.89 5 144446 167 110444681
Stomatitis 10.65 9.89 270 144181 269972 110174876
Enanthema 10.58 9.89 10 144441 1124 110443724
Aplasia pure red cell 10.57 9.89 32 144419 9546 110435302
Pseudomyopia 10.55 9.89 5 144446 174 110444674
White blood cell count abnormal 10.54 9.89 26 144425 6883 110437965
Cardiac murmur 10.49 9.89 10 144441 24618 110420230
Renal tubular necrosis 10.48 9.89 72 144379 30403 110414445
Epstein-Barr virus infection reactivation 10.47 9.89 19 144432 4065 110440783
Bronchitis 10.47 9.89 274 144177 156758 110288090
Autoimmune haemolytic anaemia 10.46 9.89 34 144417 10533 110434315
Encephalitis viral 10.40 9.89 16 144435 2991 110441857
Ageusia 10.39 9.89 52 144399 19593 110425255
Eye infection 10.36 9.89 42 144409 14476 110430372
Herpes simplex meningoencephalitis 10.36 9.89 4 144447 83 110444765
Hepatic encephalopathy 10.35 9.89 13 144438 28243 110416605
Chalazion 10.33 9.89 8 144443 686 110444162
Peripheral nerve palsy 10.27 9.89 4 144447 85 110444763
Incoherent 10.25 9.89 29 144422 8329 110436519
Fluid imbalance 10.25 9.89 8 144443 694 110444154
Electrocardiogram QT prolonged 10.19 9.89 92 144359 108868 110335980
Salivary hypersecretion 10.18 9.89 5 144446 17416 110427432
Autonomic nervous system imbalance 10.17 9.89 23 144428 5757 110439091
White blood cell morphology abnormal 10.15 9.89 3 144448 26 110444822
Anaphylactic shock 10.10 9.89 34 144417 51512 110393336
Enterocolitis infectious 10.10 9.89 17 144434 3427 110441421
Asphyxia 10.10 9.89 3 144448 14212 110430636
Fluoride increased 10.10 9.89 4 144447 89 110444759
Hypercapnic coma 10.07 9.89 7 144444 508 110444340
Skin necrosis 10.05 9.89 8 144443 21504 110423344
Depressed mood 10.05 9.89 43 144408 60766 110384082
Cerebellar ataxia 10.03 9.89 13 144438 2075 110442773
Nail discomfort 10.02 9.89 4 144447 91 110444757
Dermo-hypodermitis 10.01 9.89 11 144440 1477 110443371
Biliary dyskinesia 9.99 9.89 14 144437 2407 110442441
Infective aneurysm 9.99 9.89 11 144440 1481 110443367
Hypercalcaemia 9.98 9.89 99 144352 46558 110398290
Cells in urine 9.95 9.89 5 144446 198 110444650
Escherichia pyelonephritis 9.94 9.89 9 144442 958 110443890
Creatinine urine increased 9.94 9.89 7 144444 519 110444329
Death 9.92 9.89 782 143669 698087 109746761
Injection site pain 9.90 9.89 168 144283 177754 110267094
Hypoglycaemic seizure 9.90 9.89 9 144442 963 110443885

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J05AB11 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIVIRALS FOR SYSTEMIC USE
DIRECT ACTING ANTIVIRALS
Nucleosides and nucleotides excl. reverse transcriptase inhibitors
FDA MoA N0000020060 DNA Polymerase Inhibitors
FDA EXT N0000175459 Nucleoside Analog
FDA EPC N0000175468 Herpesvirus Nucleoside Analog DNA Polymerase Inhibitor
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000998 Antiviral Agents
FDA EPC N0000180187 Herpes Simplex Virus Nucleoside Analog DNA Polymerase Inhibitor
FDA EPC N0000180188 Herpes Zoster Virus Nucleoside Analog DNA Polymerase Inhibitor
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:36044 antiviral drug
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:64952 anti-HSV agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:149553 anticoronaviral agent

Related Drugs by ATC class:

J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors 11 drugs
acyclovirbrivudinecidofovirfamciclovirgancicloviridoxuridinemolnupiravirpenciclovirremdesivirvalganciclovirvidarabine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Herpes labialis indication 1475003
Herpes zoster indication 4740000 DOID:8536
Genital herpes simplex indication 33839006 DOID:8704
Varicella indication 38907003 DOID:8659
Recurrent genital herpes simplex indication 402894005
Suppression of Recurrent Herpes Simplex Infection in HIV indication
Suppression of Recurrent Herpes Simplex Infection indication
Prevention of Cytomegalovirus Disease off-label use
Prevention of Herpes Zoster in Immunocompromised Patient off-label use
Dehydration contraindication 34095006
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Hemolytic uremic syndrome contraindication 111407006 DOID:12554
Impaired renal function disorder contraindication 197663003




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.97 acidic
pKa2 7.83 Basic
pKa3 3.83 Basic
pKa4 2.12 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
DNA polymerase catalytic subunit Enzyme INHIBITOR WOMBAT-PK CHEMBL

External reference:

IDSource
4024006 VUID
N0000022011 NUI
D08664 KEGG_DRUG
124832-26-4 SECONDARY_CAS_RN
4020944 VANDF
4024006 VANDF
C0249458 UMLSCUI
TXC PDB_CHEM_ID
CHEMBL1349 ChEMBL_ID
CHEMBL1201110 ChEMBL_ID
DB00577 DRUGBANK_ID
135398742 PUBCHEM_CID
236081 RXNORM
169290 MMSL
41695 MMSL
5660 MMSL
d03838 MMSL
005049 NDDF
005050 NDDF
324820003 SNOMEDCT_US
412325002 SNOMEDCT_US
96098007 SNOMEDCT_US
D000077483 MESH_DESCRIPTOR_UI
CHEBI:9919 CHEBI
4824 IUPHAR_LIGAND_ID
7106 INN_ID
MZ1IW7Q79D UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
VALTREX HUMAN PRESCRIPTION DRUG LABEL 1 0173-0565 TABLET, FILM COATED 1 g ORAL NDA 26 sections
VALTREX HUMAN PRESCRIPTION DRUG LABEL 1 0173-0933 TABLET, FILM COATED 500 mg ORAL NDA 26 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-4275 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0378-4276 TABLET, FILM COATED 1 g ORAL ANDA 28 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0904-6565 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections
valacyclovir hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 10544-937 TABLET, FILM COATED 1 g ORAL ANDA 23 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 16714-697 TABLET, FILM COATED 1 g ORAL ANDA 26 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 16714-698 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-832 TABLET, FILM COATED 500 mg ORAL ANDA 27 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 21695-965 TABLET, FILM COATED 1 g ORAL ANDA 27 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 31722-704 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 31722-705 TABLET, FILM COATED 1 g ORAL ANDA 25 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-730 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-730 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 43063-771 TABLET, FILM COATED 1 g ORAL ANDA 25 sections
Valacyclovir hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 43063-778 TABLET 500 mg ORAL ANDA 26 sections
Valacyclovir Human Prescription Drug Label 1 43353-883 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 48433-144 TABLET, FILM COATED 500 mg ORAL ANDA 28 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 49483-690 TABLET 500 mg ORAL ANDA 26 sections
Valacyclovir Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 49483-691 TABLET 1 g ORAL ANDA 26 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 50090-1173 TABLET, FILM COATED 1 g ORAL ANDA 26 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 50090-2510 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 50090-2510 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 50090-2575 TABLET, FILM COATED 1 g ORAL ANDA 25 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 50090-2575 TABLET, FILM COATED 1 g ORAL ANDA 25 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 50090-3875 TABLET, FILM COATED 500 mg ORAL ANDA 25 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 50090-3880 TABLET, FILM COATED 1 g ORAL ANDA 25 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 50090-5852 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections
Valacyclovir HUMAN PRESCRIPTION DRUG LABEL 1 50090-6581 TABLET 500 mg ORAL ANDA 29 sections
Valacyclovir Hydrochloride Human Prescription Drug Label 1 50090-6918 TABLET, FILM COATED 500 mg ORAL ANDA 26 sections