fluorouracil 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
uracil type antineoplastics 26 51-21-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • 5-fluorouracil
  • adrucil
  • fluoroblastin
  • fluorouracil
  • 5-FU
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
  • Molecular weight: 130.08
  • Formula: C4H3FN2O2
  • CLOGP: -0.58
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 58.20
  • ALOGS: -1.35
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.01 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 5 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 92.25 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 28 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.23 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 26 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.64 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.12 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.065 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.879 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 11.246 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 6.353 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 92.960 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 86.260 % High 1
herg hERG pIC50 3.760 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.722 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.388 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 84.150 % High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.411 High 1
mh-clint Mouse hepatocyte intrinsic clearance 0.573 High 1
mppb Mouse plasma protein binding (% unbound) 97.370 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.007 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 93.600 % High 1
rh-clint Rat hepatocyte intrinsic clearance 0.771 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 94.520 % High 1
rppb Rat plasma protein binding (% unbound) 88.230 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 893.305 uM High 1

Approvals:

DateAgencyCompanyOrphan
April 25, 1962 FDA SPECTRUM PHARMS
Sept. 21, 2018 PMDA Kyowa Hakko Kirin Co., Ltd.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 2787.17 13.79 2147 96044 222757 90307499
Neuropathy peripheral 1620.00 13.79 1274 96917 135696 90394560
Febrile neutropenia 1484.40 13.79 1287 96904 157062 90373194
Mucosal inflammation 1254.71 13.79 780 97411 56845 90473411
Disease progression 1194.56 13.79 1134 97057 155481 90374775
Diarrhoea 1142.30 13.79 2871 95320 936319 89593937
Thrombocytopenia 902.14 13.79 1120 97071 207605 90322651
Malignant neoplasm progression 862.52 13.79 799 97392 106071 90424185
Leukopenia 734.46 13.79 712 97479 99998 90430258
Neurotoxicity 711.04 13.79 382 97809 21085 90509171
Skin toxicity 696.50 13.79 266 97925 6513 90523743
Palmar-plantar erythrodysaesthesia syndrome 683.11 13.79 408 97783 27615 90502641
Dermatitis acneiform 680.50 13.79 257 97934 6097 90524159
Metastases to liver 584.15 13.79 373 97818 28434 90501822
Arteriospasm coronary 521.82 13.79 199 97992 4851 90525405
Vomiting 455.66 13.79 1871 96320 786422 89743834
Bone marrow failure 433.20 13.79 324 97867 31897 90498359
Nausea 401.85 13.79 2303 95888 1108013 89422243
Joint swelling 389.32 13.79 45 98146 503255 90027001
Metastases to lung 387.50 13.79 232 97959 15759 90514497
Myelosuppression 386.84 13.79 377 97814 53214 90477042
Neoplasm progression 374.82 13.79 341 97850 44145 90486111
Polyneuropathy 373.72 13.79 243 97948 19098 90511158
Cardiotoxicity 364.06 13.79 198 97993 11191 90519065
Systemic lupus erythematosus 361.78 13.79 6 98185 361890 90168366
Neutrophil count decreased 354.41 13.79 412 97779 71120 90459136
Rheumatoid arthritis 343.29 13.79 11 98180 362603 90167653
Anaemia 340.11 13.79 994 97197 351808 90178448
Acute myeloid leukaemia 333.32 13.79 232 97959 20408 90509848
Pemphigus 316.43 13.79 8 98183 326856 90203400
Gastrointestinal toxicity 309.32 13.79 167 98024 9300 90520956
Abdominal discomfort 306.19 13.79 71 98120 477257 90052999
Hypokalaemia 298.84 13.79 521 97670 130595 90399661
Metastases to bone 298.03 13.79 236 97955 25269 90504987
Wound 291.07 13.79 8 98183 302972 90227284
Arthralgia 287.62 13.79 253 97938 778269 89751987
Swelling 283.75 13.79 55 98136 419003 90111253
Arthropathy 282.41 13.79 33 98158 366209 90164047
Glossodynia 274.90 13.79 19 98172 321760 90208496
Contraindicated product administered 270.34 13.79 20 98171 320119 90210137
Pulmonary embolism 270.19 13.79 498 97693 130322 90399934
Peripheral sensory neuropathy 266.00 13.79 150 98041 9100 90521156
Paronychia 263.72 13.79 142 98049 7864 90522392
Metastasis 263.22 13.79 130 98061 6007 90524249
Interstitial lung disease 261.23 13.79 366 97825 76039 90454217
Weight increased 252.86 13.79 70 98121 417857 90112399
Dehydration 252.15 13.79 612 97579 193835 90336421
Haematotoxicity 245.87 13.79 159 98032 12376 90517880
Nasopharyngitis 242.93 13.79 70 98121 407034 90123222
Posterior reversible encephalopathy syndrome 242.51 13.79 198 97993 22141 90508115
Sinusitis 240.89 13.79 41 98150 343047 90187209
Therapy partial responder 232.22 13.79 192 97999 21851 90508405
Pain 230.79 13.79 458 97733 995883 89534373
Helicobacter infection 229.86 13.79 3 98188 226847 90303409
Cardiomyopathy 229.73 13.79 184 98007 20022 90510234
Therapeutic product effect decreased 229.66 13.79 19 98172 277552 90252704
Non-cirrhotic portal hypertension 229.41 13.79 58 98133 322 90529934
Psoriatic arthropathy 223.18 13.79 5 98186 228330 90301926
Second primary malignancy 221.86 13.79 139 98052 10239 90520017
Ejection fraction decreased 220.63 13.79 201 97990 26052 90504204
Product dose omission issue 218.18 13.79 29 98162 291658 90238598
Hypomagnesaemia 217.72 13.79 229 97962 35359 90494897
Gastrointestinal perforation 213.70 13.79 101 98090 4231 90526025
Irritable bowel syndrome 209.06 13.79 3 98188 207445 90322811
Duodenal ulcer perforation 208.29 13.79 7 98184 221281 90308975
Acute promyelocytic leukaemia 206.47 13.79 68 98123 1061 90529195
Blood cholesterol increased 205.49 13.79 4 98187 208008 90322248
Hyperammonaemia 199.83 13.79 110 98081 6365 90523891
Laryngospasm 193.47 13.79 87 98104 3246 90527010
Neutropenic sepsis 193.24 13.79 159 98032 17971 90512285
Type 2 diabetes mellitus 192.82 13.79 6 98185 203238 90327018
Musculoskeletal stiffness 192.19 13.79 43 98148 296489 90233767
Mobility decreased 192.18 13.79 23 98168 250711 90279545
Headache 191.60 13.79 406 97785 862340 89667916
Asthenia 190.88 13.79 1106 97085 532645 89997611
Abdominal pain 190.59 13.79 891 97300 394830 90135426
Pericarditis 188.01 13.79 33 98158 270118 90260138
Enteritis 188.00 13.79 125 98066 10196 90520060
Discomfort 187.71 13.79 35 98156 274300 90255956
Hepatic enzyme increased 182.85 13.79 81 98110 360655 90169601
Injury 179.75 13.79 8 98183 197341 90332915
Peripheral swelling 179.61 13.79 113 98078 412993 90117263
Wheezing 174.88 13.79 25 98166 238055 90292201
Product use issue 172.11 13.79 71 98120 329848 90200408
Colorectal cancer metastatic 170.93 13.79 55 98136 794 90529462
Disease recurrence 170.14 13.79 207 97984 37446 90492810
Large intestine perforation 168.20 13.79 114 98077 9598 90520658
Metastases to lymph nodes 167.08 13.79 122 98069 11567 90518689
Ascites 166.58 13.79 231 97960 47509 90482747
Decreased appetite 162.71 13.79 822 97369 375718 90154538
Drug hypersensitivity 161.00 13.79 159 98032 463450 90066806
Maternal exposure during pregnancy 159.95 13.79 96 98095 359967 90170289
Lower respiratory tract infection 159.12 13.79 38 98153 250621 90279635
Sleep disorder 157.22 13.79 16 98175 198014 90332242
Contusion 155.75 13.79 40 98151 251176 90279080
Pyrexia 155.38 13.79 1234 96957 659251 89871005
Portal hypertension 153.77 13.79 83 98108 4618 90525638
Drug ineffective 153.14 13.79 879 97312 1383419 89146837
Osteoarthritis 152.35 13.79 17 98174 195713 90334543
Folliculitis 144.28 13.79 24 98167 204329 90325927
Depression 143.84 13.79 73 98118 300528 90229728
Blister 142.79 13.79 49 98142 254949 90275307
Pancytopenia 139.50 13.79 363 97828 119900 90410356
Neutropenic colitis 137.90 13.79 74 98117 4069 90526187
Pain in extremity 137.23 13.79 172 98019 450357 90079899
Fall 136.54 13.79 194 97997 481616 90048640
Proteinuria 133.84 13.79 145 98046 23146 90507110
Stress cardiomyopathy 131.72 13.79 112 98079 13243 90517013
Extravasation 130.73 13.79 64 98127 2900 90527356
Death 128.81 13.79 891 97300 455660 90074596
Joint range of motion decreased 128.65 13.79 4 98187 135639 90394617
Stomatitis 126.60 13.79 611 97580 274087 90256169
Urticaria 125.90 13.79 93 98098 312641 90217615
Migraine 124.54 13.79 27 98164 190365 90339891
Hyperammonaemic encephalopathy 124.22 13.79 60 98131 2639 90527617
Ileus 120.46 13.79 117 98074 16429 90513827
Cholangitis 118.92 13.79 82 98109 7100 90523156
Intestinal perforation 118.03 13.79 107 98084 13774 90516482
Congestive cardiomyopathy 117.17 13.79 82 98109 7272 90522984
Deep vein thrombosis 117.15 13.79 287 97904 91333 90438923
Psoriasis 117.11 13.79 12 98179 147742 90382514
Intestinal obstruction 115.32 13.79 170 98021 36961 90493295
Asthma 112.58 13.79 61 98130 242099 90288157
Intentional product use issue 112.53 13.79 47 98144 216845 90313411
Bursitis 111.69 13.79 8 98183 131646 90398610
Left ventricular dysfunction 111.08 13.79 106 98085 14563 90515693
Pruritus 110.03 13.79 267 97924 541258 89988998
Treatment failure 109.19 13.79 101 98090 303827 90226429
Injection site pain 108.90 13.79 27 98164 173672 90356584
Arthritis 108.88 13.79 24 98167 167291 90362965
Memory impairment 108.52 13.79 39 98152 197205 90333051
Rash pustular 108.28 13.79 81 98110 7968 90522288
Device related thrombosis 106.94 13.79 50 98141 2043 90528213
Impaired healing 101.77 13.79 64 98127 234135 90296121
Gait inability 101.60 13.79 18 98173 146438 90383818
Dysarthria 100.76 13.79 198 97993 54284 90475972
Breast cancer metastatic 99.07 13.79 101 98090 15031 90515225
Cardiac failure 98.99 13.79 302 97889 109194 90421062
Anxiety 98.78 13.79 114 98077 309658 90220598
Paraesthesia 96.64 13.79 530 97661 249796 90280460
Drug intolerance 96.25 13.79 214 97977 447377 90082879
Sepsis 96.18 13.79 418 97773 179396 90350860
White blood cell count decreased 95.99 13.79 397 97794 166712 90363544
Hospitalisation 95.09 13.79 13 98178 128087 90402169
Hyperbilirubinaemia 94.86 13.79 95 98096 13841 90516415
Colitis 94.67 13.79 224 97967 69718 90460538
Insomnia 94.65 13.79 134 98057 333340 90196916
Obesity 93.73 13.79 5 98186 105502 90424754
Confusional state 92.94 13.79 173 98018 386032 90144224
Septic shock 92.45 13.79 249 97942 83911 90446345
Lip dry 92.20 13.79 4 98187 100951 90429305
Oesophageal fistula 89.32 13.79 24 98167 175 90530081
Focal nodular hyperplasia 89.12 13.79 33 98158 739 90529517
Road traffic accident 87.23 13.79 8 98183 107618 90422638
Metastases to peritoneum 87.17 13.79 55 98136 4100 90526156
Immune thrombocytopenia 85.52 13.79 88 98103 13238 90517018
Condition aggravated 84.71 13.79 345 97846 595200 89935056
Splenomegaly 84.13 13.79 86 98105 12838 90517418
Ill-defined disorder 83.86 13.79 48 98143 184843 90345413
Loss of personal independence in daily activities 83.69 13.79 22 98169 136083 90394173
Night sweats 82.71 13.79 19 98172 128747 90401509
Nodular regenerative hyperplasia 81.81 13.79 30 98161 653 90529603
Chills 80.92 13.79 320 97871 131661 90398595
Haemolytic anaemia 80.10 13.79 80 98111 11617 90518639
Peritonitis 78.91 13.79 102 98089 19603 90510653
Sciatica 78.38 13.79 9 98182 101373 90428883
Hypercholesterolaemia 77.89 13.79 9 98182 100883 90429373
Venoocclusive liver disease 77.71 13.79 59 98132 5934 90524322
Cholinergic syndrome 77.60 13.79 29 98162 667 90529589
Influenza 77.51 13.79 27 98164 139237 90391019
Leukoencephalopathy 76.85 13.79 54 98137 4819 90525437
Febrile bone marrow aplasia 76.85 13.79 72 98119 9666 90520590
Metastases to skin 76.24 13.79 40 98151 2100 90528156
Epistaxis 76.20 13.79 234 97957 84891 90445365
Carcinoembryonic antigen increased 75.49 13.79 41 98150 2309 90527947
Ocular toxicity 75.14 13.79 32 98159 1045 90529211
Intentional product misuse 74.42 13.79 6 98185 89598 90440658
Agranulocytosis 74.38 13.79 135 98056 34867 90495389
Steatohepatitis 73.11 13.79 29 98162 787 90529469
Red blood cell sedimentation rate increased 73.09 13.79 4 98187 82591 90447665
Drug abuse 72.84 13.79 4 98187 82343 90447913
Liver injury 72.19 13.79 48 98143 170519 90359737
Infusion related reaction 70.79 13.79 224 97967 416556 90113700
Disseminated intravascular coagulation 70.35 13.79 101 98090 21437 90508819
Metastases to ovary 70.06 13.79 25 98166 502 90529754
Enterocutaneous fistula 69.46 13.79 34 98157 1540 90528716
Hypertransaminasaemia 68.25 13.79 85 98106 15740 90514516
Metastases to central nervous system 67.44 13.79 89 98102 17453 90512803
General physical health deterioration 67.22 13.79 633 97558 354482 90175774
Tumour perforation 66.54 13.79 18 98173 135 90530121
Prescribed underdose 65.26 13.79 4 98187 75015 90455241
Acute coronary syndrome 65.08 13.79 69 98122 10744 90519512
Adverse event 64.93 13.79 23 98168 117395 90412861
Hepatic failure 64.70 13.79 137 98054 39591 90490665
Trichomegaly 64.68 13.79 16 98175 80 90530176
Varices oesophageal 64.58 13.79 44 98147 3735 90526521
Injection site reaction 64.55 13.79 11 98180 92069 90438187
Breast cancer recurrent 64.44 13.79 51 98140 5452 90524804
Injection site erythema 64.33 13.79 14 98177 98488 90431768
Dizziness 64.26 13.79 375 97816 588909 89941347
Autoimmune disorder 64.12 13.79 5 98186 76739 90453517
Pneumonia 63.90 13.79 417 97774 637642 89892614
Bronchitis 63.42 13.79 44 98147 152883 90377373
Enterocolitis 63.25 13.79 67 98124 10423 90519833
Fluid retention 62.92 13.79 10 98181 88081 90442175
Hyperthermia 62.30 13.79 66 98125 10269 90519987
Anastomotic leak 61.50 13.79 24 98167 623 90529633
Intestinal ischaemia 61.28 13.79 61 98130 8822 90521434
Thrombocytopenic purpura 61.26 13.79 33 98158 1828 90528428
Adverse drug reaction 60.97 13.79 25 98166 116676 90413580
Dysgeusia 60.24 13.79 158 98033 52402 90477854
Product quality issue 58.98 13.79 8 98183 79317 90450939
Rectal perforation 58.87 13.79 22 98169 506 90529750
Gastrooesophageal reflux disease 58.84 13.79 56 98135 166281 90363975
Encephalopathy 58.83 13.79 145 98046 46299 90483957
Live birth 58.77 13.79 8 98183 79099 90451157
Gastrointestinal necrosis 58.59 13.79 39 98152 3186 90527070
Suicidal ideation 58.50 13.79 6 98185 73849 90456407
Haemolytic uraemic syndrome 58.45 13.79 37 98154 2774 90527482
Toxic leukoencephalopathy 58.37 13.79 25 98166 828 90529428
Metastases to pleura 58.37 13.79 33 98158 2011 90528245
Gait disturbance 58.04 13.79 122 98069 260374 90269882
Cholestasis 57.76 13.79 124 98067 36175 90494081
Hypocalcaemia 57.66 13.79 136 98055 42232 90488024
Hypophagia 57.46 13.79 123 98068 35814 90494442
Large intestinal obstruction 57.12 13.79 36 98155 2678 90527578
Platelet count decreased 56.89 13.79 296 97895 136673 90393583
Troponin I increased 56.57 13.79 35 98156 2520 90527736
Embolism 56.18 13.79 60 98131 9421 90520835
Colony stimulating factor therapy 55.93 13.79 20 98171 404 90529852
Dihydropyrimidine dehydrogenase deficiency 55.87 13.79 15 98176 109 90530147
Pleural effusion 55.82 13.79 255 97936 111736 90418520
Amnesia 55.47 13.79 24 98167 108481 90421775
Xeroderma 55.43 13.79 19 98172 337 90529919
Suicide attempt 55.13 13.79 8 98183 75391 90454865
Cutaneous lupus erythematosus 54.95 13.79 37 98154 3081 90527175
Respiratory failure 54.89 13.79 264 97927 118154 90412102
Ear infection 54.42 13.79 6 98185 69769 90460487
Chronic obstructive pulmonary disease 53.60 13.79 8 98183 73821 90456435
Aplasia 53.32 13.79 40 98151 3951 90526305
Aortitis 53.19 13.79 27 98164 1323 90528933
Upper respiratory tract infection 53.10 13.79 37 98154 128281 90401975
Electrocardiogram ST segment elevation 53.10 13.79 40 98151 3976 90526280
Osteonecrosis of jaw 52.65 13.79 125 98066 38978 90491278
Musculoskeletal pain 52.44 13.79 65 98126 171186 90359070
Lung disorder 52.39 13.79 51 98140 149832 90380424
Multiple organ dysfunction syndrome 51.36 13.79 177 98014 68159 90462097
Lymphangiosis carcinomatosa 50.48 13.79 28 98163 1644 90528612
Administration site extravasation 49.63 13.79 25 98166 1205 90529051
Mucosal toxicity 49.43 13.79 18 98173 384 90529872
Wound infection 49.13 13.79 27 98164 106375 90423881
Azotaemia 48.99 13.79 43 98148 5305 90524951
Hypertensive crisis 48.96 13.79 77 98114 17707 90512549
Dermatitis 48.87 13.79 87 98104 22133 90508123
Toxic cardiomyopathy 48.32 13.79 17 98174 327 90529929
Dry mouth 48.28 13.79 78 98113 183981 90346275
Rash 48.10 13.79 592 97599 795508 89734748
Jugular vein thrombosis 48.08 13.79 36 98155 3545 90526711
Subacute cutaneous lupus erythematosus 48.07 13.79 36 98155 3546 90526710
Oesophageal varices haemorrhage 47.84 13.79 26 98165 1466 90528790
COVID-19 47.71 13.79 68 98123 168775 90361481
Myelodysplastic syndrome 47.47 13.79 83 98108 20820 90509436
Hepatic cytolysis 47.35 13.79 104 98087 30812 90499444
Hormone receptor positive breast cancer 47.29 13.79 21 98170 760 90529496
Adenocarcinoma 47.13 13.79 34 98157 3162 90527094
Pregnancy 46.75 13.79 6 98185 62041 90468215
Stress 46.64 13.79 15 98176 81380 90448876
Dysentery 46.64 13.79 23 98168 1059 90529197
Adenocarcinoma of colon 46.37 13.79 32 98159 2774 90527482
Malignant respiratory tract neoplasm 46.26 13.79 11 98180 45 90530211
Hypovolaemic shock 45.80 13.79 47 98144 7047 90523209
Hypoalbuminaemia 45.39 13.79 70 98121 15827 90514429
Osteoporosis 45.29 13.79 24 98167 96507 90433749
Overdose 45.07 13.79 63 98128 157646 90372610
Stridor 44.83 13.79 39 98152 4754 90525502
Liver abscess 44.41 13.79 34 98157 3462 90526794
Metastases to chest wall 43.73 13.79 19 98172 652 90529604
Proctalgia 43.57 13.79 49 98142 8149 90522107
Colon cancer metastatic 43.46 13.79 24 98167 1397 90528859
Nasal congestion 43.36 13.79 18 98173 83396 90446860
Device related infection 43.24 13.79 90 98101 25696 90504560
Dislocation of vertebra 43.18 13.79 5 98186 55963 90474293
Subileus 43.16 13.79 34 98157 3610 90526646
Exostosis 42.92 13.79 4 98187 53130 90477126
Skin fissures 42.62 13.79 79 98112 20730 90509526
Vasospasm 42.56 13.79 21 98170 968 90529288
Aortic thrombosis 42.45 13.79 23 98168 1289 90528967
Venous pressure jugular decreased 42.44 13.79 10 98181 39 90530217
Tongue oedema 42.41 13.79 40 98151 5414 90524842
Gastric varices haemorrhage 42.37 13.79 13 98178 159 90530097
Infection 42.36 13.79 225 97966 361869 90168387
Hypersensitivity 42.06 13.79 304 97887 454373 90075883
Subclavian vein thrombosis 41.88 13.79 27 98164 2089 90528167
Thrombotic microangiopathy 41.74 13.79 67 98124 15676 90514580
Tumour ulceration 41.45 13.79 14 98177 237 90530019
Myocarditis 41.13 13.79 62 98129 13744 90516512
Intravascular haemolysis 40.69 13.79 16 98175 424 90529832
Left ventricular dilatation 40.65 13.79 18 98173 647 90529609
Xerophthalmia 40.16 13.79 18 98173 666 90529590
Injection site swelling 40.11 13.79 8 98183 59831 90470425
Liver function test increased 39.95 13.79 21 98170 84834 90445422
Foot deformity 39.93 13.79 8 98183 59643 90470613
Diaphragmatic paralysis 39.86 13.79 18 98173 678 90529578
Cachexia 39.83 13.79 43 98148 6835 90523421
Transaminases increased 39.79 13.79 109 98082 37083 90493173
Splenic artery thrombosis 39.78 13.79 10 98181 54 90530202
Feeling abnormal 39.22 13.79 76 98115 167159 90363097
Blood alkaline phosphatase increased 39.20 13.79 128 98063 47951 90482305
Cardiomyopathy acute 39.19 13.79 14 98177 282 90529974
Small intestinal obstruction 39.04 13.79 77 98114 21157 90509099
Illness 39.02 13.79 20 98171 81949 90448307
Hydrothorax 38.78 13.79 20 98171 1013 90529243
Joint stiffness 38.73 13.79 18 98173 78024 90452232
Lupus-like syndrome 38.60 13.79 4 98187 48842 90481414
Oesophagitis 38.53 13.79 68 98123 17181 90513075
Portal hypertensive gastropathy 38.53 13.79 20 98171 1027 90529229
Toxic erythema of chemotherapy 38.44 13.79 13 98178 221 90530035
Dyspepsia 38.36 13.79 100 98091 198060 90332196
Systemic scleroderma 38.35 13.79 23 98168 1566 90528690
Pharyngeal dyskinesia 38.01 13.79 9 98182 36 90530220
Sedation 37.93 13.79 4 98187 48167 90482089
Ovarian failure 37.64 13.79 23 98168 1620 90528636
Radiation skin injury 37.60 13.79 20 98171 1080 90529176
Tumour lysis syndrome 37.45 13.79 53 98138 11099 90519157
Short-bowel syndrome 37.14 13.79 17 98174 661 90529595
Myocardial ischaemia 36.91 13.79 59 98132 13755 90516501
Dysphagia 36.31 13.79 227 97964 112051 90418205
Cystitis radiation 36.29 13.79 10 98181 81 90530175
Dysaesthesia 36.09 13.79 36 98155 5219 90525037
Depilation 36.08 13.79 8 98183 22 90530234
Hyponatraemia 35.98 13.79 258 97933 133280 90396976
Onychomadesis 35.76 13.79 4 98187 45994 90484262
Hepatic lesion 35.57 13.79 37 98154 5636 90524620
Inflammation 35.43 13.79 89 98102 178503 90351753
Leukocytosis 35.34 13.79 93 98098 30897 90499359
Carbohydrate antigen 19-9 increased 35.28 13.79 13 98178 287 90529969
White blood cell count abnormal 35.10 13.79 42 98149 7462 90522794
Incorrect dose administered 35.05 13.79 21 98170 78909 90451347
Peritoneal disorder 34.80 13.79 16 98175 629 90529627
Sleep disorder due to a general medical condition 34.50 13.79 4 98187 44734 90485522
Osteonecrosis 34.37 13.79 83 98108 26158 90504098
Electrolyte imbalance 34.26 13.79 78 98113 23667 90506589
Medication error 34.24 13.79 25 98166 84627 90445629
Factor VII deficiency 34.19 13.79 9 98182 60 90530196
Heart rate decreased 34.14 13.79 8 98183 53497 90476759
Neuromyotonia 33.94 13.79 9 98182 62 90530194
Anorectal varices haemorrhage 33.82 13.79 7 98184 12 90530244
Nephritis bacterial 33.79 13.79 8 98183 32 90530224
Respiratory disorder 33.66 13.79 14 98177 64802 90465454
Tumour necrosis 33.65 13.79 18 98173 983 90529273
Abdominal abscess 33.53 13.79 35 98156 5352 90524904
Recall phenomenon 33.51 13.79 17 98174 832 90529424
Colon cancer recurrent 33.10 13.79 9 98182 69 90530187
Disability 33.09 13.79 3 98188 40742 90489514
Muscular weakness 33.02 13.79 114 98077 206552 90323704
Vena cava thrombosis 32.81 13.79 25 98166 2527 90527729
Venous thrombosis 32.74 13.79 35 98156 5502 90524754
Abortion spontaneous 32.72 13.79 9 98182 54047 90476209
C-reactive protein increased 32.52 13.79 95 98096 181294 90348962
Acute lymphocytic leukaemia 32.50 13.79 26 98165 2822 90527434
Portal vein thrombosis 32.35 13.79 27 98164 3111 90527145
Type II hypersensitivity 32.34 13.79 8 98183 40 90530216
Metastases to bone marrow 32.29 13.79 15 98176 604 90529652
Metastases to meninges 32.16 13.79 29 98162 3706 90526550
Metastases to spine 32.11 13.79 29 98162 3714 90526542
Pseudocirrhosis 31.81 13.79 17 98174 927 90529329
Gastrointestinal stoma complication 31.77 13.79 24 98167 2395 90527861
Xerosis 31.70 13.79 20 98171 1491 90528765
Balance disorder 31.69 13.79 35 98156 97045 90433211
Malignant pleural effusion 31.59 13.79 26 98165 2938 90527318
Miller Fisher syndrome 31.56 13.79 10 98181 137 90530119
Pulmonary veno-occlusive disease 31.37 13.79 20 98171 1518 90528738
Inappropriate schedule of product administration 31.09 13.79 73 98118 149860 90380396
Bladder tamponade 30.97 13.79 10 98181 146 90530110
Metastases to reproductive organ 30.82 13.79 6 98185 6 90530250
Growth of eyelashes 30.73 13.79 11 98180 223 90530033
Pulmonary fistula 30.34 13.79 6 98185 7 90530249
Macular degeneration 30.29 13.79 3 98188 37967 90492289
Serotonin syndrome 30.21 13.79 3 98188 37884 90492372
Prinzmetal angina 30.19 13.79 17 98174 1028 90529228
Rhabdomyolysis 30.17 13.79 9 98182 51247 90479009
Throat tightness 30.15 13.79 85 98106 29399 90500857
Hepatectomy 30.07 13.79 10 98181 161 90530095
Acute abdomen 29.94 13.79 20 98171 1643 90528613
Organising pneumonia 29.91 13.79 39 98152 7558 90522698
Pancreatic haemorrhage 29.77 13.79 7 98184 27 90530229
Haemoglobin decreased 29.74 13.79 287 97904 161669 90368587
Laryngitis 29.71 13.79 9 98182 50744 90479512
Aortic dissection 29.60 13.79 23 98168 2394 90527862
Cataract 29.54 13.79 21 98170 72071 90458185
Metastatic neoplasm 29.47 13.79 31 98160 4784 90525472
Bacterial translocation 29.43 13.79 15 98176 741 90529515
Gastrointestinal stoma output increased 29.43 13.79 14 98177 595 90529661
Blood creatine increased 29.37 13.79 37 98154 6930 90523326
Acute kidney injury 29.34 13.79 499 97692 319888 90210368
Recurrent cancer 29.25 13.79 23 98168 2436 90527820
Neck pain 29.22 13.79 49 98142 113914 90416342
Encapsulating peritoneal sclerosis 29.16 13.79 12 98179 359 90529897
Bone marrow oedema syndrome 28.90 13.79 8 98183 66 90530190
Stoma site haemorrhage 28.79 13.79 18 98173 1320 90528936
Cardiogenic shock 28.49 13.79 74 98117 24394 90505862
Band sensation 28.36 13.79 17 98174 1156 90529100
Acute interstitial pneumonitis 28.30 13.79 15 98176 804 90529452
Atypical haemolytic uraemic syndrome 28.30 13.79 16 98175 975 90529281
Necrosis ischaemic 28.24 13.79 16 98175 979 90529277
Ileal perforation 28.18 13.79 13 98178 515 90529741
Drug reaction with eosinophilia and systemic symptoms 28.07 13.79 6 98185 42752 90487504
Conjunctival filtering bleb leak 28.07 13.79 6 98185 13 90530243
Tumour haemorrhage 28.00 13.79 21 98170 2073 90528183
Systemic infection 27.91 13.79 30 98161 4745 90525511
Respiratory distress 27.64 13.79 99 98092 38847 90491409
Hyperglycaemia 27.61 13.79 119 98072 50851 90479405
Oral pain 27.53 13.79 88 98103 32595 90497661
ECG signs of myocardial ischaemia 27.44 13.79 8 98183 81 90530175
Constipation 27.25 13.79 441 97750 279954 90250302
Laryngeal dyspnoea 27.17 13.79 10 98181 220 90530036
Erythema 27.13 13.79 373 97818 228873 90301383
Metastases to pelvis 27.10 13.79 13 98178 563 90529693
Cytopenia 27.06 13.79 59 98132 17390 90512866
Visual impairment 27.01 13.79 65 98126 132300 90397956
Inferior vena cava stenosis 26.93 13.79 6 98185 17 90530239
Drug interaction 26.92 13.79 182 98009 276271 90253985
Nicotinic acid deficiency 26.85 13.79 8 98183 88 90530168
Ventricular hypokinesia 26.82 13.79 31 98160 5310 90524946
Sinus disorder 26.77 13.79 3 98188 34444 90495812
Renal salt-wasting syndrome 26.70 13.79 12 98179 447 90529809
Skin disorder 26.64 13.79 94 98097 36612 90493644
Wrong technique in product usage process 26.61 13.79 23 98168 71548 90458708
Blood phosphorus decreased 26.60 13.79 30 98161 5004 90525252
Dry skin 26.59 13.79 175 98016 87898 90442358
Bronchospasm 26.59 13.79 65 98126 20644 90509612
Renal failure 26.49 13.79 237 97954 130770 90399486
Nasal septum perforation 26.41 13.79 14 98177 751 90529505
Ileus paralytic 26.36 13.79 30 98161 5055 90525201
No adverse event 26.32 13.79 21 98170 67961 90462295
Cardiac ventricular thrombosis 26.30 13.79 16 98175 1118 90529138
Hyperpyrexia 26.24 13.79 29 98162 4732 90525524
Mixed adenoneuroendocrine carcinoma 26.20 13.79 6 98185 20 90530236
Underdose 25.98 13.79 13 98178 54004 90476252
Thrombotic thrombocytopenic purpura 25.96 13.79 27 98164 4111 90526145
Oedema 25.96 13.79 120 98071 200175 90330081
Hepatic function abnormal 25.79 13.79 109 98082 46179 90484077
Gastrointestinal anastomotic leak 25.65 13.79 10 98181 259 90529997
Chronic myeloid leukaemia 25.57 13.79 22 98169 2642 90527614
Acute leukaemia 25.51 13.79 16 98175 1180 90529076
Metastases to the mediastinum 25.48 13.79 13 98178 644 90529612
K-ras gene mutation 25.15 13.79 6 98185 25 90530231
Somnolence 24.94 13.79 129 98062 208955 90321301
Hypoaesthesia 24.90 13.79 219 97972 313991 90216265
Fistula 24.89 13.79 46 98145 12043 90518213
Acute respiratory distress syndrome 24.86 13.79 78 98113 28608 90501648
Delirium 24.83 13.79 47 98144 104312 90425944
Nephrotic syndrome 24.83 13.79 35 98156 7304 90522952
Tumour marker increased 24.73 13.79 31 98160 5776 90524480
Streptococcal bacteraemia 24.71 13.79 20 98171 2207 90528049
Tympanic membrane disorder 24.67 13.79 9 98182 193 90530063
Blood pressure fluctuation 24.63 13.79 13 98178 52400 90477856
Cerebral infarction 24.62 13.79 74 98117 26522 90503734
Superior vena cava syndrome 24.14 13.79 13 98178 720 90529536
Therapy cessation 24.08 13.79 5 98186 36356 90493900
Enterocolitis infectious 24.03 13.79 19 98172 2028 90528228
Pelvic abscess 23.94 13.79 19 98172 2039 90528217
Blood pressure systolic increased 23.90 13.79 17 98174 58328 90471928
Unevaluable event 23.79 13.79 15 98176 54833 90475423
Rectal cancer recurrent 23.63 13.79 6 98185 34 90530222
Hypotony of eye 23.61 13.79 9 98182 219 90530037
Laryngeal oedema 23.55 13.79 33 98158 6848 90523408
Gastrointestinal disorder 23.52 13.79 172 98019 256515 90273741
Pericardial effusion 23.11 13.79 90 98101 36743 90493513
Phrenic nerve paralysis 23.10 13.79 10 98181 340 90529916
Soft tissue necrosis 23.07 13.79 13 98178 787 90529469
Systolic dysfunction 23.06 13.79 18 98173 1886 90528370
Colon cancer 22.98 13.79 42 98149 10902 90519354
Blepharospasm 22.91 13.79 16 98175 55429 90474827
Protein urine 22.89 13.79 13 98178 799 90529457
Microangiopathic haemolytic anaemia 22.79 13.79 13 98178 806 90529450
Therapy interrupted 22.72 13.79 13 98178 50095 90480161
Hepatic cirrhosis 22.71 13.79 21 98170 63232 90467024
Infusion related hypersensitivity reaction 22.53 13.79 12 98179 650 90529606
Atrial thrombosis 22.49 13.79 19 98172 2226 90528030
Tonic clonic movements 22.43 13.79 17 98174 1705 90528551
Biliary tract infection 22.42 13.79 13 98178 831 90529425
Gastroenteritis aeromonas 22.42 13.79 6 98185 43 90530213
Emotional distress 22.39 13.79 6 98185 36656 90493600
Altered state of consciousness 22.24 13.79 80 98111 31452 90498804
Hypocapnia 22.23 13.79 11 98180 510 90529746
Sneezing 22.23 13.79 3 98188 29866 90500390
Chemotherapy toxicity attenuation 22.23 13.79 5 98186 15 90530241
Carbohydrate antigen 15-3 increased 22.22 13.79 18 98173 1989 90528267
Catabolic state 21.95 13.79 6 98185 47 90530209
Heart rate increased 21.82 13.79 57 98134 112845 90417411
Tachycardia 21.79 13.79 264 97927 157409 90372847
Ischaemic stroke 21.78 13.79 63 98128 22103 90508153
Duodenal perforation 21.71 13.79 14 98177 1084 90529172
Acute pulmonary oedema 21.70 13.79 38 98153 9542 90520714
Drug dependence 21.70 13.79 3 98188 29324 90500932
Hypophosphataemia 21.66 13.79 49 98142 14805 90515451
Pancreatitis acute 21.41 13.79 80 98111 32035 90498221
Procedural pain 21.26 13.79 5 98186 33355 90496901
Diarrhoea haemorrhagic 21.24 13.79 40 98151 10623 90519633
Hyperchylomicronaemia 21.22 13.79 6 98185 54 90530202
Hepatotoxicity 21.08 13.79 102 98089 45740 90484516
Catheter site bruise 21.05 13.79 11 98180 573 90529683
Pulmonary alveolar haemorrhage 20.88 13.79 29 98162 5969 90524287
Pneumonitis 20.84 13.79 99 98092 44071 90486185
Toxic skin eruption 20.77 13.79 50 98141 15724 90514532
Malignant peritoneal neoplasm 20.71 13.79 12 98179 766 90529490
Wernicke's encephalopathy 20.56 13.79 5 98186 23 90530233
Aortic intramural haematoma 20.54 13.79 7 98184 122 90530134
Periodontal disease 20.33 13.79 16 98175 1696 90528560
Renal tubular disorder 20.26 13.79 21 98170 3186 90527070
Drug level increased 20.17 13.79 3 98188 27759 90502497
Gastric perforation 20.11 13.79 17 98174 1994 90528262
Performance status decreased 20.09 13.79 24 98167 4256 90526000
Type IV hypersensitivity reaction 20.07 13.79 23 98168 3903 90526353
SAPHO syndrome 19.93 13.79 7 98184 134 90530122
Immunodeficiency 19.91 13.79 11 98180 43223 90487033
Full blood count decreased 19.83 13.79 4 98187 29685 90500571
Myeloproliferative neoplasm 19.75 13.79 11 98180 651 90529605
Pelvic fluid collection 19.71 13.79 13 98178 1046 90529210
Portal vein dilatation 19.59 13.79 5 98186 29 90530227
Immune-mediated adverse reaction 19.56 13.79 12 98179 851 90529405
Precursor T-lymphoblastic lymphoma/leukaemia 19.44 13.79 6 98185 75 90530181
Alopecia 19.42 13.79 399 97792 494672 90035584
Odynophagia 19.36 13.79 35 98156 9008 90521248
Immune-mediated myocarditis 19.32 13.79 14 98177 1311 90528945
Hip arthroplasty 19.32 13.79 33 98158 76175 90454081
Incorrect drug administration rate 19.31 13.79 26 98165 5197 90525059
Psychotic disorder 19.28 13.79 5 98186 31225 90499031
Oesophageal-pulmonary fistula 19.28 13.79 4 98187 7 90530249
Cardiac failure acute 19.26 13.79 41 98150 11888 90518368
Gene mutation 19.26 13.79 17 98174 2113 90528143
Duodenal ulcer 19.23 13.79 36 98155 9516 90520740
Nephrolithiasis 19.20 13.79 15 98176 49070 90481186
Accidental exposure to product 19.19 13.79 11 98180 42355 90487901
Extrasystoles 19.17 13.79 27 98164 5630 90524626
Incorrect route of product administration 19.15 13.79 16 98175 50610 90479646
Neutrophil count abnormal 19.14 13.79 23 98168 4105 90526151
Cough 19.07 13.79 283 97908 368679 90161577
Pneumatosis intestinalis 19.05 13.79 21 98170 3416 90526840
Toxic encephalopathy 19.05 13.79 34 98157 8665 90521591
Hepatic vein stenosis 19.04 13.79 5 98186 33 90530223
Embolism arterial 19.03 13.79 13 98178 1108 90529148
Venous thrombosis limb 18.93 13.79 21 98170 3441 90526815
Oesophageal stenosis 18.82 13.79 22 98169 3814 90526442
Hypertriglyceridaemia 18.79 13.79 32 98159 7857 90522399
Anal erosion 18.78 13.79 5 98186 35 90530221
Aorto-oesophageal fistula 18.78 13.79 5 98186 35 90530221
Ulcer haemorrhage 18.77 13.79 3 98188 26318 90503938
Necrosis 18.72 13.79 29 98162 6581 90523675
Lymphadenopathy mediastinal 18.69 13.79 20 98171 3147 90527109
Gait apraxia 18.66 13.79 5 98186 36 90530220
Onycholysis 18.59 13.79 17 98174 2213 90528043
Acute myocardial infarction 18.54 13.79 81 98110 34809 90495447
Wrong rate 18.45 13.79 7 98184 168 90530088
Marchiafava-Bignami disease 18.32 13.79 4 98187 10 90530246
Haemolysis 18.30 13.79 33 98158 8477 90521779
Therapy non-responder 18.25 13.79 81 98110 136623 90393633
Oesophageal perforation 18.18 13.79 9 98182 418 90529838
Pigmentation disorder 18.12 13.79 27 98164 5922 90524334
Pulmonary artery thrombosis 18.09 13.79 11 98180 768 90529488
Multiple sclerosis 18.09 13.79 4 98187 27836 90502420
Frequent bowel movements 18.07 13.79 21 98170 56914 90473342
Bradycardia 18.05 13.79 40 98151 83807 90446449
Endocardial fibrosis 18.04 13.79 4 98187 11 90530245
Splenic marginal zone lymphoma recurrent 18.04 13.79 4 98187 11 90530245
Muscle spasms 18.04 13.79 180 98011 251703 90278553
Keratoacanthoma 18.00 13.79 10 98181 589 90529667
Anorectal disorder 17.94 13.79 16 98175 2015 90528241
Vaginal fistula 17.94 13.79 10 98181 593 90529663
Stomatitis haemorrhagic 17.91 13.79 6 98185 99 90530157
Malignant gastrointestinal obstruction 17.88 13.79 5 98186 43 90530213
Epilepsy 17.87 13.79 39 98152 82167 90448089
Endometrial dysplasia 17.78 13.79 4 98187 12 90530244
Respiratory tract congestion 17.68 13.79 4 98187 27406 90502850
Intracardiac thrombus 17.68 13.79 17 98174 2357 90527899
Jaundice 17.67 13.79 76 98115 32441 90497815
Dysphonia 17.64 13.79 123 98068 62961 90467295
Cutaneous tuberculosis 17.54 13.79 7 98184 193 90530063
Fistula of small intestine 17.54 13.79 9 98182 451 90529805
Brachiocephalic vein thrombosis 17.53 13.79 6 98185 106 90530150
Phlebitis 17.52 13.79 30 98161 7400 90522856
Percussion test abnormal 17.49 13.79 3 98188 0 90530256
Vascular access site swelling 17.49 13.79 3 98188 0 90530256
Cardiac myxoma 17.48 13.79 8 98183 311 90529945
Dandy-Walker syndrome 17.42 13.79 6 98185 108 90530148
Dysaesthesia pharynx 17.28 13.79 7 98184 201 90530055
Hallucination 17.24 13.79 28 98163 65931 90464325
Sudden death 17.05 13.79 37 98154 10872 90519384
Retinopathy 16.89 13.79 20 98171 3514 90526742
Blood culture positive 16.88 13.79 24 98167 5048 90525208
Eosinophilia 16.81 13.79 5 98186 28528 90501728
Rib fracture 16.77 13.79 4 98187 26431 90503825
Pulmonary toxicity 16.77 13.79 38 98153 11493 90518763
Lichenoid keratosis 16.74 13.79 17 98174 2517 90527739
Small intestinal perforation 16.65 13.79 15 98176 1914 90528342
Treatment noncompliance 16.50 13.79 19 98172 51708 90478548
Tooth avulsion 16.46 13.79 5 98186 59 90530197
Drug resistance 16.42 13.79 71 98120 30378 90499878
Retroperitoneal abscess 16.40 13.79 7 98184 230 90530026
Peripheral motor neuropathy 16.36 13.79 15 98176 1958 90528298
Menopause 16.22 13.79 19 98172 3302 90526954
Post procedural diarrhoea 16.21 13.79 8 98183 369 90529887
Adverse reaction 16.12 13.79 6 98185 29706 90500550
Dermatitis atopic 16.02 13.79 3 98188 23469 90506787
Malignant neoplasm of pleura 16.02 13.79 5 98186 65 90530191
Monoparesis 16.02 13.79 15 98176 2012 90528244
Hydronephrosis 16.00 13.79 39 98152 12363 90517893
Female genital tract fistula 15.87 13.79 49 98142 17819 90512437
Ventricular fibrillation 15.86 13.79 42 98149 14002 90516254
Hypertensive encephalopathy 15.85 13.79 10 98181 745 90529511
Cold dysaesthesia 15.85 13.79 4 98187 22 90530234
Sinus congestion 15.81 13.79 5 98186 27419 90502837
Red blood cell nucleated morphology present 15.70 13.79 4 98187 23 90530233
Glucocorticoid deficiency 15.66 13.79 9 98182 566 90529690
Vesical fistula 15.62 13.79 6 98185 149 90530107
Productive cough 15.59 13.79 38 98153 77025 90453231
Scintillating scotoma 15.59 13.79 6 98185 150 90530106
Biliary fistula 15.56 13.79 4 98187 24 90530232
Vision blurred 15.55 13.79 64 98127 110229 90420027
Terminal ileitis 15.53 13.79 12 98179 1238 90529018
Colon cancer stage IV 15.49 13.79 7 98184 264 90529992
Mucosal disorder 15.48 13.79 17 98174 2754 90527502
Granulocyte count decreased 15.39 13.79 16 98175 2436 90527820
Chemotherapy 15.37 13.79 14 98177 1813 90528443
Herpes simplex encephalitis 15.34 13.79 8 98183 415 90529841
Portal shunt 15.28 13.79 4 98187 26 90530230
Bacteraemia 15.24 13.79 56 98135 22244 90508012
Eczema 15.22 13.79 21 98170 52849 90477407
Blood creatine phosphokinase increased 15.18 13.79 9 98182 34014 90496242
Metastases to abdominal cavity 15.16 13.79 9 98182 601 90529655
Onychomycosis 15.16 13.79 11 98180 37365 90492891
Tongue pigmentation 15.15 13.79 4 98187 27 90530229
Withdrawal syndrome 15.12 13.79 3 98188 22521 90507735
Foot fracture 15.07 13.79 5 98186 26601 90503655
Cystitis 15.05 13.79 31 98160 66687 90463569
Gamma-glutamyltransferase increased 15.04 13.79 81 98110 37871 90492385
Chemical burns of eye 15.01 13.79 5 98186 81 90530175
Blood creatinine increased 14.99 13.79 172 98019 101214 90429042
Refractory anaemia with an excess of blasts 14.99 13.79 8 98183 435 90529821
Arterial thrombosis 14.93 13.79 13 98178 1587 90528669
Gastrointestinal motility disorder 14.90 13.79 25 98166 6066 90524190
Failure to thrive 14.86 13.79 30 98161 8381 90521875
Bone marrow infiltration 14.86 13.79 10 98181 832 90529424
Panic attack 14.85 13.79 5 98186 26360 90503896
Anaemia of malignant disease 14.84 13.79 9 98182 625 90529631
Localised infection 14.80 13.79 9 98182 33553 90496703
Tumour fistulisation 14.79 13.79 4 98187 30 90530226
Dry eye 14.76 13.79 25 98166 57906 90472350
Metastases to neck 14.68 13.79 5 98186 87 90530169
Gingival atrophy 14.67 13.79 4 98187 31 90530225
Electrocardiogram ST segment depression 14.66 13.79 18 98173 3285 90526971
Gastric disorder 14.66 13.79 9 98182 33375 90496881
Ear pain 14.61 13.79 25 98166 57677 90472579
Spinal cord compression 14.55 13.79 22 98169 4889 90525367
Colitis ulcerative 14.46 13.79 27 98164 60239 90470017
Paraneoplastic syndrome 14.46 13.79 9 98182 655 90529601
HER2 gene amplification 14.45 13.79 4 98187 33 90530223
Vitamin B1 deficiency 14.40 13.79 8 98183 471 90529785
Wound dehiscence 14.38 13.79 24 98167 5798 90524458
Device issue 14.37 13.79 7 98184 29530 90500726
Hyperventilation 14.36 13.79 26 98165 6702 90523554
Liver disorder 14.35 13.79 75 98116 121194 90409062
Chronic sinusitis 14.34 13.79 4 98187 23798 90506458
Abdominal pain upper 14.28 13.79 264 97927 332410 90197846
Oesophageal ulcer perforation 14.20 13.79 3 98188 6 90530250
Optic disc hyperaemia 14.20 13.79 3 98188 6 90530250
Enterobacter sepsis 14.14 13.79 7 98184 325 90529931
Biliary dilatation 14.06 13.79 16 98175 2695 90527561
Multiple-drug resistance 14.06 13.79 28 98163 7748 90522508
Skin haemorrhage 14.03 13.79 3 98188 21377 90508879
Anastomotic complication 14 13.79 7 98184 332 90529924
Hiatus hernia 13.96 13.79 5 98186 25356 90504900
Sarcopenia 13.92 13.79 7 98184 336 90529920
Skin reaction 13.89 13.79 48 98143 18505 90511751
Catheter site cellulitis 13.88 13.79 7 98184 338 90529918
Pigment nephropathy 13.86 13.79 4 98187 39 90530217
Product intolerance 13.86 13.79 4 98187 39 90530217
Pneumothorax 13.84 13.79 49 98142 19118 90511138
Endothelial dysfunction 13.83 13.79 6 98185 205 90530051
Palpitations 13.81 13.79 89 98102 136639 90393617

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 1627.61 13.60 2358 115885 197073 42306019
Neuropathy peripheral 1469.34 13.60 1603 116640 100250 42402842
Diarrhoea 1204.45 13.60 3381 114862 457468 42045624
Dermatitis acneiform 1030.67 13.60 479 117764 7260 42495832
Skin toxicity 1022.91 13.60 453 117790 6096 42496996
Arteriospasm coronary 888.59 13.60 373 117870 4365 42498727
Disease progression 836.36 13.60 1458 116785 142198 42360894
Mucosal inflammation 759.55 13.60 805 117438 48569 42454523
Stomatitis 692.89 13.60 774 117469 49555 42453537
Thrombocytopenia 607.92 13.60 1509 116734 188770 42314322
Paronychia 565.34 13.60 263 117980 3992 42499100
Metastases to liver 552.37 13.60 416 117827 15910 42487182
Palmar-plantar erythrodysaesthesia syndrome 534.69 13.60 449 117794 20133 42482959
Interstitial lung disease 470.89 13.60 808 117435 77654 42425438
Neurotoxicity 469.25 13.60 443 117800 23208 42479884
Malignant neoplasm progression 463.88 13.60 966 117277 107434 42395658
Polyneuropathy 403.98 13.60 367 117876 18294 42484798
Leukopenia 387.22 13.60 722 117521 74024 42429068
Decreased appetite 386.97 13.60 1296 116947 191841 42311251
Nausea 367.35 13.60 2109 116134 394690 42108402
Therapy partial responder 353.87 13.60 352 117891 19669 42483423
Myelosuppression 350.88 13.60 494 117749 39967 42463125
Gastrointestinal toxicity 342.04 13.60 183 118060 3796 42499296
Peripheral sensory neuropathy 327.21 13.60 237 118006 8525 42494567
Cardiotoxicity 314.20 13.60 217 118026 7228 42495864
Febrile neutropenia 309.99 13.60 1174 117069 184529 42318563
Product dose omission issue 294.06 13.60 40 118203 154325 42348767
Hypomagnesaemia 291.43 13.60 377 117866 28111 42474981
Vomiting 285.39 13.60 1567 116676 288156 42214936
Metastases to lung 281.83 13.60 242 118001 11182 42491910
Arthralgia 276.15 13.60 112 118131 205126 42297966
Hyperammonaemia 273.94 13.60 204 118039 7662 42495430
Drug interaction 241.67 13.60 231 118012 266768 42236324
Completed suicide 235.40 13.60 7 118236 96458 42406634
Neutrophil count decreased 234.27 13.60 533 117710 62882 42440210
Headache 226.18 13.60 199 118044 239170 42263922
Pneumatosis intestinalis 220.75 13.60 147 118096 4605 42498487
Haematotoxicity 212.55 13.60 203 118040 10782 42492310
Neoplasm progression 208.06 13.60 324 117919 28676 42474416
Gastrointestinal perforation 196.96 13.60 134 118109 4352 42498740
Portal venous gas 196.89 13.60 68 118175 441 42502651
Proteinuria 195.31 13.60 278 117965 22705 42480387
Carcinoembryonic antigen increased 186.28 13.60 76 118167 822 42502270
Hyperammonaemic encephalopathy 185.60 13.60 108 118135 2650 42500442
Rash pustular 183.21 13.60 146 118097 6069 42497023
Drug ineffective 176.64 13.60 1028 117215 629169 41873923
Dehydration 175.08 13.60 818 117425 140949 42362143
Fall 174.00 13.60 238 118005 234282 42268810
Portal hypertension 173.09 13.60 127 118116 4660 42498432
Bone marrow failure 170.34 13.60 319 117924 32774 42470318
Enteritis 165.45 13.60 176 118067 10640 42492452
Intestinal obstruction 163.09 13.60 280 117963 26878 42476214
General physical health deterioration 159.23 13.60 834 117409 150412 42352680
Alopecia 159.22 13.60 289 117954 28987 42474105
Skin reaction 158.83 13.60 142 118101 6925 42496167
Weight increased 151.60 13.60 55 118188 107928 42395164
Acute coronary syndrome 147.74 13.60 194 118049 14671 42488421
Metastases to peritoneum 146.78 13.60 89 118154 2360 42500732
Pyrexia 144.48 13.60 1698 116545 392344 42110748
Hospitalisation 137.39 13.60 21 118222 74309 42428783
Anxiety 136.08 13.60 80 118163 118480 42384612
Colorectal cancer metastatic 135.77 13.60 62 118181 899 42502193
Asthma 134.49 13.60 10 118233 62304 42440788
Injection site pain 131.53 13.60 7 118236 57791 42445301
Intentional product misuse 130.61 13.60 11 118232 61889 42441203
Somnolence 128.71 13.60 121 118122 140984 42362108
Intentional overdose 128.25 13.60 3 118240 51453 42451639
Chills 123.62 13.60 553 117690 93513 42409579
Myalgia 118.76 13.60 59 118184 96021 42407071
Rhabdomyolysis 117.82 13.60 35 118208 77984 42425108
Cardiac failure congestive 117.79 13.60 45 118198 85557 42417535
Plasma cell myeloma 117.71 13.60 3 118240 47575 42455517
Chronic obstructive pulmonary disease 116.25 13.60 18 118225 63096 42439996
Asthenia 114.93 13.60 1237 117006 279556 42223536
Suicide attempt 113.70 13.60 3 118240 46097 42456995
Depression 113.18 13.60 86 118157 111277 42391815
Hypokalaemia 112.41 13.60 445 117798 71276 42431816
Pulmonary embolism 109.98 13.60 636 117607 118976 42384116
Stress 108.58 13.60 3 118240 44209 42458883
Pain in extremity 106.46 13.60 158 118085 150446 42352646
Insomnia 103.66 13.60 105 118138 118148 42384944
Joint swelling 103.65 13.60 30 118213 67992 42435100
Stress cardiomyopathy 103.21 13.60 75 118168 2710 42500382
Suicidal ideation 100.40 13.60 9 118234 48152 42454940
Overdose 99.86 13.60 87 118156 105177 42397915
Wheezing 97.82 13.60 17 118226 54764 42448328
Influenza 97.38 13.60 26 118217 62149 42440943
Abdominal pain 97.26 13.60 879 117364 189592 42313500
Hiccups 97.22 13.60 143 118100 12028 42491064
Anastomotic leak 97.12 13.60 46 118197 728 42502364
Death 97.09 13.60 839 117404 470346 42032746
Electrocardiogram ST segment elevation 96.83 13.60 100 118143 5839 42497253
Peripheral swelling 95.24 13.60 67 118176 90203 42412889
Conjunctivitis 93.38 13.60 145 118098 12794 42490298
Neutropenic colitis 92.97 13.60 86 118157 4384 42498708
Ileus 92.92 13.60 180 118063 18959 42484133
Aggression 92.75 13.60 8 118235 44155 42458937
Paraesthesia 92.11 13.60 426 117817 73033 42430059
Mucosal toxicity 91.89 13.60 34 118209 276 42502816
Metastases to lymph nodes 90.67 13.60 97 118146 5901 42497191
Oesophageal fistula 90.43 13.60 34 118209 290 42502802
Peritonitis 90.16 13.60 175 118068 18458 42484634
Incorrect dose administered 89.16 13.60 19 118224 52955 42450137
Tumour necrosis 89.01 13.60 56 118187 1588 42501504
Intestinal perforation 88.65 13.60 129 118114 10745 42492347
Tumour perforation 87.82 13.60 38 118205 481 42502611
Pneumonia 87.21 13.60 751 117492 421398 42081694
Dizziness 86.22 13.60 377 117866 248877 42254215
Folliculitis 85.99 13.60 91 118152 5467 42497625
Nasopharyngitis 85.16 13.60 65 118178 83931 42419161
Large intestine perforation 84.93 13.60 118 118125 9418 42493674
Feeling abnormal 83.04 13.60 45 118198 69741 42433351
Hallucination 82.89 13.60 28 118215 57479 42445613
Gastrointestinal anastomotic leak 82.60 13.60 38 118205 561 42502531
Therapeutic product effect decreased 82.46 13.60 7 118236 39143 42463949
Drug reaction with eosinophilia and systemic symptoms 82.20 13.60 10 118233 42065 42461027
Pelvic abscess 81.31 13.60 45 118198 1000 42502092
Anaemia 79.00 13.60 1152 117091 279126 42223966
Psoriasis 78.66 13.60 19 118224 48585 42454507
Rheumatoid arthritis 78.38 13.60 12 118231 42428 42460664
Condition aggravated 78.20 13.60 415 117828 260339 42242753
Subileus 77.64 13.60 70 118173 3451 42499641
Sinusitis 77.50 13.60 18 118225 47274 42455818
Toxicity to various agents 77.16 13.60 350 117893 228786 42274306
Leukoencephalopathy 76.45 13.60 81 118162 4873 42498219
COVID-19 75.88 13.60 128 118115 115820 42387272
Tumour lysis syndrome 74.53 13.60 180 118063 22051 42481041
Intestinal ischaemia 73.11 13.60 109 118134 9279 42493813
Anastomotic complication 72.78 13.60 32 118211 422 42502670
Musculoskeletal stiffness 72.07 13.60 35 118208 57730 42445362
Septic shock 71.93 13.60 468 117775 91204 42411888
Device related infection 71.01 13.60 167 118076 20112 42482980
Arthritis 70.97 13.60 15 118228 42050 42461042
Extravasation 70.13 13.60 56 118187 2334 42500758
Oesophagitis 69.90 13.60 140 118103 15107 42487985
Toxic leukoencephalopathy 69.77 13.60 36 118207 691 42502401
Small intestinal obstruction 69.24 13.60 149 118094 16912 42486180
Aorto-oesophageal fistula 67.70 13.60 18 118225 38 42503054
Cholangitis 67.56 13.60 113 118130 10614 42492478
Prostate cancer 67.43 13.60 20 118223 44623 42458469
Muscle spasms 67.08 13.60 84 118159 85960 42417132
Aortic thrombosis 67.01 13.60 40 118203 1030 42502062
Focal nodular hyperplasia 66.61 13.60 23 118220 149 42502943
Intravascular haemolysis 66.47 13.60 32 118211 526 42502566
Blood glucose increased 66.21 13.60 64 118179 73635 42429457
Abdominal discomfort 65.71 13.60 67 118176 75188 42427904
Loss of personal independence in daily activities 65.55 13.60 28 118215 49788 42453304
Contusion 64.91 13.60 18 118225 41967 42461125
Electrocardiogram QT prolonged 64.62 13.60 26 118217 47919 42455173
Oesophageal stenosis 64.47 13.60 50 118193 1996 42501096
Enterocolitis 64.42 13.60 106 118137 9823 42493269
Ileal perforation 64.39 13.60 39 118204 1032 42502060
Hypersensitivity 63.35 13.60 380 117863 71990 42431102
Tremor 62.50 13.60 108 118135 96821 42406271
Disseminated intravascular coagulation 61.99 13.60 180 118063 24614 42478478
Rectal tenesmus 61.89 13.60 39 118204 1109 42501983
Administration site extravasation 61.86 13.60 34 118209 745 42502347
Inappropriate schedule of product administration 61.70 13.60 107 118136 95795 42407297
Pain 61.58 13.60 412 117831 244436 42258656
Intentional product use issue 61.54 13.60 65 118178 71768 42431324
Colitis 61.27 13.60 274 117969 46298 42456794
Confusional state 60.66 13.60 249 117994 167348 42335744
Memory impairment 60.30 13.60 32 118211 50190 42452902
Venoocclusive liver disease 60.24 13.60 105 118138 10197 42492895
Foetal exposure during pregnancy 60.04 13.60 28 118215 47283 42455809
Malignant ascites 59.53 13.60 31 118212 607 42502485
Hyperbilirubinaemia 58.68 13.60 157 118086 20478 42482614
Full blood count abnormal 58.61 13.60 7 118236 29869 42473223
Disturbance in attention 58.58 13.60 7 118236 29859 42473233
Dermatitis 58.02 13.60 112 118131 11763 42491329
Skin disorder 57.66 13.60 138 118105 16806 42486286
Agitation 57.59 13.60 56 118187 64258 42438834
Necrotising fasciitis 57.52 13.60 67 118176 4479 42498613
Bradycardia 56.25 13.60 94 118149 85390 42417702
Hypoalbuminaemia 56.24 13.60 130 118113 15480 42487612
Oesophagobronchial fistula 55.96 13.60 21 118222 178 42502914
Large intestinal obstruction 55.83 13.60 43 118200 1699 42501393
Carbohydrate antigen 19-9 increased 55.78 13.60 23 118220 256 42502836
Sedation 55.41 13.60 9 118234 30466 42472626
Venous thrombosis 55.33 13.60 62 118181 3973 42499119
Immune-mediated hepatic disorder 53.51 13.60 49 118194 2465 42500627
Rectal cancer metastatic 53.27 13.60 22 118221 246 42502846
Pneumonitis 53.05 13.60 243 118000 41475 42461617
Gastrointestinal necrosis 52.50 13.60 61 118182 4067 42499025
Cholinergic syndrome 52.50 13.60 29 118214 642 42502450
Cough 52.47 13.60 285 117958 177818 42325274
Embolism 52.13 13.60 90 118153 8673 42494419
Recall phenomenon 52.01 13.60 28 118215 588 42502504
Dyspnoea 51.96 13.60 890 117353 441731 42061361
Ascites 51.78 13.60 301 117942 56377 42446715
Drug ineffective for unapproved indication 51.73 13.60 32 118211 46131 42456961
Azotaemia 50.62 13.60 72 118171 5872 42497220
Epistaxis 49.88 13.60 337 117906 66489 42436603
Lower respiratory tract infection 49.85 13.60 26 118217 41180 42461912
Treatment noncompliance 49.84 13.60 21 118222 37651 42465441
Device related thrombosis 49.24 13.60 37 118206 1408 42501684
Rectal perforation 49.16 13.60 26 118217 526 42502566
Swelling 48.90 13.60 48 118195 54837 42448255
Fluid retention 48.05 13.60 14 118229 31605 42471487
Dysphagia 48.03 13.60 356 117887 72363 42430729
Coronary artery disease 47.84 13.60 47 118196 53673 42449419
Drug hypersensitivity 47.33 13.60 131 118112 99258 42403834
Unevaluable event 47.18 13.60 18 118225 34270 42468822
Colitis ulcerative 46.99 13.60 8 118235 26167 42476925
No adverse event 46.64 13.60 25 118218 38996 42464096
Blood pressure fluctuation 46.63 13.60 9 118234 26899 42476193
Monocyte chemotactic protein-1 increased 46.57 13.60 22 118221 346 42502746
Alpha tumour necrosis factor increased 46.29 13.60 22 118221 351 42502741
Blood cholesterol increased 46.22 13.60 9 118234 26732 42476360
Cellulitis 46.06 13.60 62 118181 61523 42441569
Irritability 45.50 13.60 11 118232 28117 42474975
Pulmonary artery thrombosis 45.15 13.60 29 118214 853 42502239
Pulmonary ossification 45.13 13.60 14 118229 61 42503031
Anastomotic fistula 45.13 13.60 15 118228 85 42503007
Tumour haemorrhage 45 13.60 53 118190 3585 42499507
Drug withdrawal syndrome 44.98 13.60 4 118239 21545 42481547
Vasospasm 44.95 13.60 25 118218 561 42502531
Subclavian vein thrombosis 44.31 13.60 30 118213 966 42502126
Eosinophilia 44.07 13.60 18 118225 32881 42470211
Evans syndrome 43.32 13.60 22 118221 408 42502684
Adverse drug reaction 43.28 13.60 25 118218 37409 42465683
Portal vein thrombosis 43.09 13.60 58 118185 4491 42498601
Oesophageal perforation 42.97 13.60 32 118211 1201 42501891
Fistula 42.86 13.60 78 118165 7834 42495258
Heart rate decreased 42.80 13.60 24 118219 36508 42466584
Perforation 42.72 13.60 23 118220 483 42502609
Gait disturbance 42.45 13.60 135 118108 97865 42405227
Colon cancer recurrent 42.33 13.60 15 118228 106 42502986
Hepatic lesion 42.11 13.60 57 118186 4437 42498655
Small intestinal perforation 41.72 13.60 46 118197 2895 42500197
Colon cancer metastatic 41.67 13.60 36 118207 1676 42501416
Abnormal behaviour 41.52 13.60 11 118232 26440 42476652
Tumour marker increased 41.36 13.60 27 118216 817 42502275
Immune-mediated renal disorder 41.34 13.60 22 118221 451 42502641
Chronic kidney disease 41.30 13.60 42 118201 47199 42455893
Bronchitis 41.22 13.60 42 118201 47159 42455933
Urticaria 41.19 13.60 90 118153 73946 42429146
Duodenal perforation 40.85 13.60 35 118208 1611 42501481
Nephrolithiasis 40.62 13.60 26 118217 36804 42466288
Accidental overdose 40.46 13.60 14 118229 28316 42474776
Acral peeling skin syndrome 40.32 13.60 12 118231 44 42503048
Transdifferentiation of neoplasm 40.30 13.60 13 118230 66 42503026
Hypoglycaemia 40.13 13.60 65 118178 59789 42443303
Cytomegalovirus infection 39.65 13.60 20 118223 32286 42470806
Neoplasm recurrence 39.33 13.60 43 118200 2681 42500411
Drug level increased 39.09 13.60 12 118231 26188 42476904
Laryngospasm 38.95 13.60 37 118206 1951 42501141
Stoma site haemorrhage 38.91 13.60 29 118214 1090 42502002
Lung neoplasm malignant 38.78 13.60 4 118239 19143 42483949
Productive cough 38.47 13.60 52 118191 51515 42451577
Myocardial infarction 38.42 13.60 195 118048 123814 42379278
Blood pressure increased 38.39 13.60 149 118094 101779 42401313
Odynophagia 38.28 13.60 68 118175 6702 42496390
Gastric perforation 38.16 13.60 45 118198 3048 42500044
Illness 37.95 13.60 11 118232 24919 42478173
Sleep apnoea syndrome 37.93 13.60 7 118236 21601 42481491
Diabetes mellitus 37.77 13.60 68 118175 60019 42443073
Toxic erythema of chemotherapy 37.71 13.60 15 118228 151 42502941
Liver abscess 37.69 13.60 57 118186 4913 42498179
Injury 37.55 13.60 8 118235 22308 42480784
Respiratory arrest 37.35 13.60 16 118227 28408 42474684
Interleukin level increased 37.16 13.60 26 118217 884 42502208
Accidental exposure to product 37.12 13.60 6 118237 20387 42482705
Sleep disorder due to a general medical condition 37.08 13.60 3 118240 17450 42485642
Cardiac disorder 36.85 13.60 49 118194 48883 42454209
Blood creatine phosphokinase increased 36.82 13.60 48 118195 48290 42454802
Product use issue 36.65 13.60 101 118142 76650 42426442
Gastric stenosis 36.48 13.60 14 118229 127 42502965
Sleep disorder 36.39 13.60 48 118195 48047 42455045
Vena cava thrombosis 36.34 13.60 32 118211 1529 42501563
Anal erythema 35.97 13.60 13 118230 98 42502994
Subdural haematoma 35.61 13.60 10 118233 23128 42479964
Pulmonary toxicity 35.59 13.60 76 118167 8579 42494513
Balance disorder 35.59 13.60 48 118195 47597 42455495
White blood cell count decreased 35.55 13.60 465 117778 109931 42393161
Colorectal cancer recurrent 35.53 13.60 12 118231 72 42503020
Head injury 35.42 13.60 7 118236 20575 42482517
Hepatic venous pressure gradient abnormal 35.37 13.60 10 118233 29 42503063
Adenocarcinoma 35.34 13.60 36 118207 2068 42501024
Left ventricular dysfunction 35.25 13.60 90 118153 11411 42491681
Swollen tongue 34.94 13.60 8 118235 21223 42481869
Sepsis 34.83 13.60 760 117483 198574 42304518
End stage renal disease 34.76 13.60 3 118240 16555 42486537
Incorrect drug administration rate 34.55 13.60 36 118207 2124 42500968
Anaphylactoid reaction 34.50 13.60 42 118201 2941 42500151
Cachexia 34.30 13.60 72 118171 8032 42495060
Skin fissures 34.22 13.60 80 118163 9596 42493496
Prinzmetal angina 33.98 13.60 29 118214 1328 42501764
Hepatectomy 33.96 13.60 13 118230 117 42502975
Nicotinic acid deficiency 33.77 13.60 13 118230 119 42502973
Trichomegaly 33.74 13.60 10 118233 36 42503056
Hyperlipidaemia 33.67 13.60 9 118234 21507 42481585
Enterovesical fistula 33.56 13.60 25 118218 939 42502153
Vision blurred 33.54 13.60 61 118182 53638 42449454
Type II hypersensitivity 33.45 13.60 11 118232 60 42503032
Dysphonia 33.45 13.60 162 118081 28288 42474804
Stomal varices 33.12 13.60 13 118230 126 42502966
Psychotic disorder 33.07 13.60 20 118223 29188 42473904
Incorrect route of product administration 33.04 13.60 13 118230 24292 42478800
Nephrotic syndrome 32.95 13.60 74 118169 8644 42494448
Metastasis 32.94 13.60 52 118191 4653 42498439
Colitis microscopic 32.86 13.60 42 118201 3091 42500001
Pancreatic neuroendocrine tumour metastatic 32.85 13.60 13 118230 129 42502963
Wrong technique in product usage process 32.82 13.60 42 118201 42593 42460499
Anal haemorrhage 32.50 13.60 40 118203 2833 42500259
Nasal congestion 32.29 13.60 21 118222 29480 42473612
Bacterial translocation 32.27 13.60 21 118222 632 42502460
Gout 32.06 13.60 19 118224 28036 42475056
Laryngeal oedema 31.87 13.60 47 118196 3961 42499131
Dihydropyrimidine dehydrogenase deficiency 31.85 13.60 12 118231 103 42502989
Nodular regenerative hyperplasia 31.70 13.60 25 118218 1023 42502069
International normalised ratio increased 31.65 13.60 53 118190 48115 42454977
Gastrointestinal obstruction 31.54 13.60 26 118217 1134 42501958
Balanoposthitis 31.43 13.60 30 118213 1591 42501501
Hypophagia 31.33 13.60 153 118090 26803 42476289
Respiratory depression 31.27 13.60 7 118236 18861 42484231
Erythema 31.25 13.60 449 117794 108344 42394748
Pulmonary oedema 31.10 13.60 63 118180 53209 42449883
Peritoneal disorder 31.01 13.60 16 118227 307 42502785
Obstructive airways disorder 30.88 13.60 15 118228 24744 42478348
Stoma site pain 30.61 13.60 22 118221 781 42502311
Blood pressure systolic increased 30.49 13.60 20 118223 27948 42475144
Onycholysis 30.45 13.60 24 118219 981 42502111
UGT1A1 gene mutation 30.38 13.60 8 118235 16 42503076
Heart rate increased 30.23 13.60 64 118179 53191 42449901
Xerosis 30.21 13.60 23 118220 893 42502199
Hypertransaminasaemia 30.16 13.60 74 118169 9153 42493939
Osteoarthritis 30.11 13.60 15 118228 24390 42478702
Oral pain 30.10 13.60 90 118153 12506 42490586
Delusion 30.05 13.60 3 118240 14731 42488361
Electrolyte imbalance 29.97 13.60 110 118133 16991 42486101
Tinnitus 29.82 13.60 22 118221 28916 42474176
Erectile dysfunction 29.72 13.60 16 118227 24897 42478195
Visual impairment 29.67 13.60 46 118197 43067 42460025
Peritoneal neoplasm 29.63 13.60 9 118234 36 42503056
Obesity 29.61 13.60 5 118238 16454 42486638
Temperature intolerance 29.57 13.60 50 118193 4738 42498354
Medication error 29.52 13.60 29 118214 33125 42469967
Product prescribing error 29.39 13.60 18 118225 26094 42476998
Cytomegalovirus oesophagitis 29.37 13.60 19 118224 566 42502526
Pharyngeal inflammation 29.32 13.60 20 118223 652 42502440
Neutropenic sepsis 29.15 13.60 104 118139 15842 42487250
Acute abdomen 29.14 13.60 32 118211 2005 42501087
Fixed eruption 29.12 13.60 35 118208 2419 42500673
Mobility decreased 29.06 13.60 33 118210 35273 42467819
Pelvic fluid collection 29.03 13.60 14 118229 231 42502861
Viral infection 29.00 13.60 13 118230 22470 42480622
Lymphoma 28.99 13.60 3 118240 14318 42488774
Premature baby 28.92 13.60 14 118229 23139 42479953
Pruritus 28.88 13.60 360 117883 188411 42314681
Eyelash changes 28.88 13.60 8 118235 21 42503071
Hypervolaemia 28.85 13.60 14 118229 23111 42479981
Injection site erythema 28.80 13.60 10 118233 20185 42482907
Sciatic nerve palsy 28.69 13.60 9 118234 41 42503051
Jugular vein thrombosis 28.67 13.60 32 118211 2042 42501050
Fatigue 28.53 13.60 1479 116764 434162 42068930
Therapy interrupted 28.49 13.60 13 118230 22237 42480855
Induration 28.36 13.60 24 118219 1086 42502006
Papilloedema 28.27 13.60 40 118203 3246 42499846
Upper respiratory tract infection 28.08 13.60 46 118197 42127 42460965
Cardiomyopathy acute 28.06 13.60 10 118233 72 42503020
Biliary tract infection 28.00 13.60 21 118222 797 42502295
Palmar erythema 27.68 13.60 18 118225 541 42502551
Non-cirrhotic portal hypertension 27.62 13.60 16 118227 389 42502703
Acne 27.57 13.60 92 118151 13552 42489540
Localised infection 27.53 13.60 11 118232 20362 42482730
Joint injury 27.44 13.60 4 118239 14672 42488420
Nail toxicity 27.38 13.60 9 118234 49 42503043
Hallucination, visual 27.35 13.60 12 118231 21008 42482084
Bronchiectasis 27.34 13.60 8 118235 18011 42485081
Blood creatine decreased 27.21 13.60 14 118229 267 42502825
Transplant rejection 27.11 13.60 3 118240 13585 42489507
Respiratory alkalosis 27.11 13.60 33 118210 2311 42500781
Mouth ulceration 26.85 13.60 97 118146 14866 42488226
Hypovolaemic shock 26.79 13.60 68 118175 8591 42494501
Right ventricular ejection fraction decreased 26.65 13.60 9 118234 54 42503038
Prostatic specific antigen increased 26.64 13.60 7 118236 16918 42486174
Emotional distress 26.61 13.60 6 118237 16087 42487005
Limb injury 26.51 13.60 4 118239 14301 42488791
Heart rate irregular 26.51 13.60 6 118237 16044 42487048
Febrile bone marrow aplasia 26.50 13.60 75 118168 10106 42492986
Eastern Cooperative Oncology Group performance status worsened 26.43 13.60 25 118218 1311 42501781
Deep vein thrombosis 26.39 13.60 328 117915 76629 42426463
Splenomegaly 26.06 13.60 105 118138 16942 42486150
Diffuse alveolar damage 26.01 13.60 34 118209 2558 42500534
Insulin autoimmune syndrome 26.00 13.60 17 118226 516 42502576
Oesophageal carcinoma recurrent 25.95 13.60 8 118235 34 42503058
Pancreatic carcinoma recurrent 25.84 13.60 10 118233 93 42502999
Cell-mediated cytotoxicity 25.76 13.60 8 118235 35 42503057
Anaemia of malignant disease 25.76 13.60 17 118226 524 42502568
Injection site reaction 25.72 13.60 6 118237 15715 42487377
Anger 25.66 13.60 3 118240 13015 42490077
Lymphangiosis carcinomatosa 25.63 13.60 22 118221 1015 42502077
Proteus infection 25.59 13.60 25 118218 1365 42501727
Tracheal stenosis 25.50 13.60 14 118229 306 42502786
Colony stimulating factor therapy 25.33 13.60 12 118231 190 42502902
Hypercreatininaemia 25.31 13.60 17 118226 540 42502552
Organising pneumonia 25.25 13.60 61 118182 7471 42495621
Pulmonary fibrosis 25.21 13.60 143 118100 26538 42476554
Arthropathy 25.09 13.60 27 118216 29570 42473522
Cardiac murmur 25.04 13.60 3 118240 12772 42490320
Contraindicated product administered 25.04 13.60 20 118223 25252 42477840
Peripheral sensorimotor neuropathy 25.01 13.60 29 118214 1929 42501163
Influenza like illness 24.89 13.60 31 118212 31809 42471283
Vocal cord paralysis 24.88 13.60 23 118220 1171 42501921
Liver function test abnormal 24.83 13.60 32 118211 32359 42470733
Gastrooesophageal reflux disease 24.81 13.60 55 118188 44968 42458124
Carbohydrate antigen 15-3 increased 24.77 13.60 9 118234 69 42503023
Lewis-Sumner syndrome 24.77 13.60 9 118234 69 42503023
Cataract 24.76 13.60 29 118214 30575 42472517
Gynaecomastia 24.51 13.60 3 118240 12564 42490528
Haematoma 24.39 13.60 25 118218 27998 42475094
Haemorrhagic tumour necrosis 24.28 13.60 6 118237 8 42503084
Proctitis 24.20 13.60 35 118208 2898 42500194
Back pain 24.14 13.60 264 117979 141512 42361580
Blood glucose decreased 24.13 13.60 5 118238 14214 42488878
Nail disorder 24.10 13.60 31 118212 2296 42500796
Pulmonary infarction 23.80 13.60 25 118218 1489 42501603
Ischaemic stroke 23.59 13.60 123 118120 22110 42480982
PIK3CA-activated mutation 23.59 13.60 10 118233 120 42502972
Dry skin 23.54 13.60 221 118022 48117 42454975
Myoclonus 23.41 13.60 9 118234 17056 42486036
Tumour pseudoprogression 23.40 13.60 21 118222 1029 42502063
Eye pain 23.33 13.60 9 118234 17021 42486071
Aphthous ulcer 23.33 13.60 51 118192 5850 42497242
Conjunctival filtering bleb leak 23.12 13.60 6 118237 11 42503081
Myasthenia gravis 23.00 13.60 8 118235 16129 42486963
Dyskinesia 22.85 13.60 22 118221 25368 42477724
Ear infection 22.79 13.60 4 118239 12800 42490292
Faecaluria 22.78 13.60 6 118237 12 42503080
Therapy non-responder 22.75 13.60 74 118169 53285 42449807
Oesophageal varices haemorrhage 22.71 13.60 38 118205 3569 42499523
Hepatic failure 22.62 13.60 182 118061 37918 42465174
Gastric ischaemia 22.52 13.60 8 118235 57 42503035
Angioedema 22.51 13.60 53 118190 42424 42460668
Multiple organ dysfunction syndrome 22.51 13.60 167 118076 96868 42406224
Blood triglycerides increased 22.45 13.60 8 118235 15888 42487204
Abdominal abscess 22.43 13.60 46 118197 5047 42498045
Koebner phenomenon 22.40 13.60 8 118235 58 42503034
Mental disorder 22.37 13.60 11 118232 18018 42485074
Rib fracture 22.30 13.60 9 118234 16562 42486530
Diaphragmatic operation 22.30 13.60 7 118236 32 42503060
Dysaesthesia pharynx 22.28 13.60 8 118235 59 42503033
Bacterial colitis 22.28 13.60 8 118235 59 42503033
Miosis 22.26 13.60 5 118238 13441 42489651
Radiation skin injury 22.20 13.60 18 118225 767 42502325
Radiation mucositis 22.16 13.60 12 118231 255 42502837
Hypoferritinaemia 22.16 13.60 6 118237 14 42503078
Corneal toxicity 22.16 13.60 6 118237 14 42503078
Vascular device infection 22.13 13.60 51 118192 6059 42497033
Venous thrombosis limb 22.13 13.60 30 118213 2339 42500753
Change of bowel habit 22.09 13.60 21 118222 1108 42501984
Hepatic enzyme increased 22.04 13.60 60 118183 45724 42457368
Treatment failure 22.02 13.60 94 118149 62530 42440562
Immune-mediated dermatitis 21.95 13.60 22 118221 1239 42501853
Enterocutaneous fistula 21.95 13.60 22 118221 1239 42501853
Adverse event 21.84 13.60 20 118223 23620 42479472
Perineal disorder 21.83 13.60 8 118235 63 42503029
Therapy cessation 21.79 13.60 15 118228 20435 42482657
Laboratory test abnormal 21.76 13.60 19 118224 22959 42480133
Systemic infection 21.74 13.60 46 118197 5159 42497933
Mental impairment 21.59 13.60 4 118239 12313 42490779
Delirium 21.59 13.60 74 118169 52445 42450647
Movement disorder 21.45 13.60 7 118236 14691 42488401
Ventricular dysfunction 21.42 13.60 42 118201 4461 42498631
Astringent therapy 21.33 13.60 6 118237 17 42503075
Diabetes mellitus inadequate control 21.30 13.60 8 118235 15382 42487710
Hypersomnia 21.26 13.60 7 118236 14611 42488481
Pneumonitis chemical 21.23 13.60 12 118231 278 42502814
Oesophageal cancer metastatic 21.23 13.60 13 118230 351 42502741
Performance status decreased 21.23 13.60 43 118200 4677 42498415
Prothrombin level decreased 21.22 13.60 21 118222 1165 42501927
Proctalgia 21.21 13.60 55 118188 7038 42496054
Varices oesophageal 21.12 13.60 41 118202 4324 42498768
Perforation bile duct 21.10 13.60 8 118235 70 42503022
Portal vein embolisation 21.07 13.60 6 118237 18 42503074
Catheter site thrombosis 21.07 13.60 10 118233 159 42502933
Rectal stenosis 21.05 13.60 11 118232 217 42502875
Eczema 21.03 13.60 39 118204 34047 42469045
Fistula of small intestine 21.00 13.60 16 118227 622 42502470
Respiratory symptom 20.83 13.60 3 118240 11103 42491989
Hernia 20.74 13.60 3 118240 11070 42492022
Abdominal infection 20.70 13.60 30 118213 2489 42500603
Neck pain 20.68 13.60 32 118211 29982 42473110
Second primary malignancy 20.64 13.60 66 118177 9509 42493583
Palpitations 20.59 13.60 72 118171 50725 42452367
NPM1 gene mutation 20.59 13.60 9 118234 117 42502975
Vertigo 20.58 13.60 40 118203 34307 42468785
Rectal adenocarcinoma 20.56 13.60 19 118224 967 42502125
Pulmonary hypertension 20.54 13.60 21 118222 23548 42479544
Hyperthermia 20.47 13.60 79 118164 12495 42490597
Pseudocirrhosis 20.38 13.60 6 118237 21 42503071
Cerebral haemorrhage 20.35 13.60 49 118194 38917 42464175
Suture rupture 20.32 13.60 14 118229 464 42502628
Seizure 20.32 13.60 225 118018 120336 42382756
Cerebrovascular accident 20.32 13.60 172 118071 96988 42406104
Gastrointestinal ischaemia 20.31 13.60 12 118231 303 42502789
Gastroenteritis radiation 20.28 13.60 12 118231 304 42502788
Protein urine 20.27 13.60 19 118224 985 42502107
Oedema peripheral 20.24 13.60 261 117982 135815 42367277
Injection site haemorrhage 20.18 13.60 4 118239 11732 42491360
Adenocarcinoma metastatic 20.07 13.60 8 118235 81 42503011
Blood phosphorus increased 20.06 13.60 5 118238 12520 42490572
Cardiac ventricular thrombosis 20.02 13.60 25 118218 1797 42501295
Thrombotic thrombocytopenic purpura 19.97 13.60 37 118206 3767 42499325
Haemoglobinuria 19.97 13.60 16 118227 670 42502422
Frequent bowel movements 19.91 13.60 18 118225 21389 42481703
Amnesia 19.90 13.60 30 118213 28407 42474685
Vascular access complication 19.90 13.60 13 118230 394 42502698
Cerebral vasoconstriction 19.89 13.60 11 118232 244 42502848
Hyperkalaemia 19.86 13.60 136 118107 80322 42422770
Rectosigmoid cancer 19.86 13.60 10 118233 182 42502910
Oesophageal haemorrhage 19.86 13.60 22 118221 1392 42501700
Thrombocytopenic purpura 19.75 13.60 21 118222 1268 42501824
Primitive neuroectodermal tumour 19.73 13.60 8 118235 85 42503007
Appendicitis 19.57 13.60 17 118226 20596 42482496
Growth of eyelashes 19.57 13.60 8 118235 87 42503005
Oesophageal-pulmonary fistula 19.56 13.60 6 118237 25 42503067
Night sweats 19.53 13.60 16 118227 19953 42483139
Cardiomyopathy 19.51 13.60 105 118138 19105 42483987
Procalcitonin decreased 19.50 13.60 11 118232 254 42502838
Herpes zoster 19.43 13.60 50 118193 38827 42464265
Superior vena cava syndrome 19.39 13.60 16 118227 699 42502393
Microgenia 19.33 13.60 5 118238 9 42503083
Hyperphosphataemia 19.32 13.60 6 118237 12998 42490094
Therapeutic response unexpected 19.31 13.60 4 118239 11377 42491715
Infectious pleural effusion 19.25 13.60 33 118210 3162 42499930
Hepatic atrophy 19.24 13.60 10 118233 195 42502897
Jaundice cholestatic 19.20 13.60 44 118199 5209 42497883
Interventricular septum rupture 19.19 13.60 6 118237 27 42503065
Fingerprint loss 19.12 13.60 7 118236 55 42503037
Toxic cardiomyopathy 19.11 13.60 13 118230 422 42502670
Pneumoperitoneum 19.08 13.60 28 118215 2350 42500742
Acute respiratory distress syndrome 19.08 13.60 146 118097 29962 42473130
Eosinophil percentage decreased 19.04 13.60 11 118232 266 42502826
Hepatitis B 19.02 13.60 51 118192 6660 42496432
Ischiorectal hernia 18.99 13.60 5 118238 10 42503082
Acute promyelocytic leukaemia 18.98 13.60 16 118227 720 42502372
Dysentery 18.97 13.60 13 118230 427 42502665
Subacute cutaneous lupus erythematosus 18.94 13.60 22 118221 1466 42501626
Enterocolitis haemorrhagic 18.93 13.60 19 118224 1072 42502020
Duodenal ulcer perforation 18.93 13.60 24 118219 1752 42501340
Gene mutation 18.87 13.60 24 118219 1757 42501335
Soft tissue disorder 18.87 13.60 17 118226 837 42502255
Wound dehiscence 18.76 13.60 36 118207 3764 42499328
Muscular weakness 18.75 13.60 145 118098 83353 42419739
Brain oedema 18.73 13.60 11 118232 16316 42486776
Product storage error 18.73 13.60 4 118239 11136 42491956
Intestinal strangulation 18.67 13.60 6 118237 30 42503062
Unresponsive to stimuli 18.45 13.60 37 118206 31366 42471726
Guillain-Barre syndrome 18.41 13.60 53 118190 7210 42495882
Overflow diarrhoea 18.39 13.60 7 118236 62 42503030
Clostridial infection 18.27 13.60 36 118207 3838 42499254
Oral dysaesthesia 18.16 13.60 8 118235 106 42502986
Onychoclasis 18.14 13.60 29 118214 2623 42500469
Abdominal pain lower 18.10 13.60 74 118169 12018 42491074
Renal disorder 18.02 13.60 33 118210 28947 42474145
Pachymeningitis 17.91 13.60 9 118234 163 42502929
Red blood cell sedimentation rate increased 17.88 13.60 3 118240 9921 42493171
Type 2 diabetes mellitus 17.82 13.60 15 118228 18456 42484636
Gastrointestinal stenosis 17.76 13.60 9 118234 166 42502926
Haemoptysis 17.68 13.60 67 118176 46100 42456992
Myopathy 17.68 13.60 8 118235 13753 42489339
Perihepatic abscess 17.52 13.60 8 118235 116 42502976
Circulatory collapse 17.51 13.60 119 118124 23517 42479575
Peritoneal adhesions 17.46 13.60 8 118235 117 42502975
Hepatic cancer recurrent 17.45 13.60 11 118232 313 42502779
Eye pruritus 17.44 13.60 5 118238 11407 42491685
Ectropion 17.38 13.60 9 118234 174 42502918
Mucocutaneous rash 17.36 13.60 6 118237 39 42503053
Radiation hepatitis 17.23 13.60 6 118237 40 42503052
Osteoporosis 17.16 13.60 10 118233 14896 42488196
Product substitution issue 17.15 13.60 5 118238 11285 42491807
Dystonia 17.12 13.60 7 118236 12783 42490309
Acute myeloid leukaemia 17.05 13.60 113 118130 22143 42480949
Tooth disorder 16.97 13.60 6 118237 11973 42491119
Immune-mediated enterocolitis 16.96 13.60 44 118199 5633 42497459
Xeroderma 16.93 13.60 9 118234 184 42502908
Blood pressure diastolic decreased 16.89 13.60 4 118239 10371 42492721
Osteoradionecrosis 16.89 13.60 7 118236 79 42503013
Acute cutaneous lupus erythematosus 16.89 13.60 7 118236 79 42503013
Hypercreatinaemia 16.84 13.60 10 118233 255 42502837
Polyserositis 16.82 13.60 11 118232 334 42502758
Oesophageal squamous cell carcinoma metastatic 16.80 13.60 4 118239 4 42503088
Intrahepatic portal hepatic venous fistula 16.80 13.60 4 118239 4 42503088
Underdose 16.75 13.60 13 118230 16653 42486439
Diffuse large B-cell lymphoma 16.73 13.60 3 118240 9451 42493641
Product quality issue 16.67 13.60 15 118228 17867 42485225
Lymph node abscess 16.66 13.60 5 118238 19 42503073
Road traffic accident 16.65 13.60 17 118226 19076 42484016
Type I hypersensitivity 16.65 13.60 25 118218 2141 42500951
Intervertebral disc protrusion 16.64 13.60 5 118238 11067 42492025
Gastrointestinal stoma complication 16.57 13.60 21 118222 1532 42501560
Hepatitis B surface antigen positive 16.54 13.60 8 118235 133 42502959
Duodenal stenosis 16.39 13.60 11 118232 349 42502743
Aortitis 16.38 13.60 14 118229 642 42502450
Capillary leak syndrome 16.36 13.60 28 118215 2679 42500413
Jaundice 16.27 13.60 157 118086 34432 42468660
Osteomyelitis 16.15 13.60 16 118227 18207 42484885
Pulmonary congestion 16.15 13.60 12 118231 15718 42487374
Monocytopenia 16.15 13.60 7 118236 89 42503003
Drug intolerance 16.09 13.60 144 118099 80280 42422812
Full blood count decreased 16.09 13.60 20 118223 20540 42482552
Intestinal transit time abnormal 16.08 13.60 5 118238 22 42503070
Adenocarcinoma of colon 16.07 13.60 34 118209 3813 42499279
Aplasia 16.00 13.60 39 118204 4804 42498288
Electromyogram abnormal 15.98 13.60 6 118237 51 42503041
Traumatic ulcer 15.90 13.60 5 118238 23 42503069
Restlessness 15.90 13.60 36 118207 29213 42473879
Peritoneal haematoma 15.87 13.60 7 118236 93 42502999
Arterial thrombosis 15.85 13.60 22 118221 1754 42501338
Cheilitis 15.79 13.60 27 118216 2581 42500511
Colitis ischaemic 15.75 13.60 50 118193 7176 42495916
Stomal hernia 15.59 13.60 11 118232 379 42502713
Acute motor-sensory axonal neuropathy 15.58 13.60 8 118235 152 42502940
Neurosarcoidosis 15.57 13.60 9 118234 218 42502874
Pleural fistula 15.56 13.60 5 118238 25 42503067
Radiation interaction 15.56 13.60 5 118238 25 42503067
Rectal haemorrhage 15.55 13.60 208 118035 49398 42453694
Deafness neurosensory 15.52 13.60 33 118210 3713 42499379
Immune-mediated myocarditis 15.51 13.60 24 118219 2110 42500982
Immune thrombocytopenia 15.51 13.60 67 118176 11149 42491943
Dysstasia 15.45 13.60 10 118233 14076 42489016
Paraesthesia oral 15.41 13.60 40 118203 5123 42497969
Epstein-Barr virus infection 15.33 13.60 4 118239 9714 42493378
Axillary vein thrombosis 15.31 13.60 10 118233 303 42502789
Visceral venous thrombosis 15.24 13.60 5 118238 27 42503065
Eczema impetiginous 15.24 13.60 5 118238 27 42503065
Perioral dermatitis 15.24 13.60 9 118234 227 42502865
Activated partial thromboplastin time prolonged 15.24 13.60 13 118230 15890 42487202
Necrotising oesophagitis 15.20 13.60 16 118227 955 42502137
Eyelash thickening 15.19 13.60 4 118239 8 42503084
Bile duct stenosis 15.18 13.60 19 118224 1369 42501723
Cutaneous lupus erythematosus 15.17 13.60 15 118228 831 42502261
Encapsulating peritoneal sclerosis 15.16 13.60 13 118230 599 42502493
Inferior vena caval occlusion 15.12 13.60 6 118237 60 42503032
Bronchopulmonary aspergillosis 15.10 13.60 19 118224 19410 42483682
Neuropathic muscular atrophy 15.09 13.60 5 118238 28 42503064
VIth nerve disorder 15.09 13.60 5 118238 28 42503064
Mydriasis 15.05 13.60 3 118240 8767 42494325
Myocarditis 15.02 13.60 97 118146 18841 42484251
Nodule 15.02 13.60 8 118235 12526 42490566
Dysgeusia 15.02 13.60 153 118090 34036 42469056
Anorectal disorder 14.96 13.60 18 118225 1245 42501847
Renal salt-wasting syndrome 14.96 13.60 11 118232 405 42502687
Glomerular filtration rate decreased 14.91 13.60 14 118229 16337 42486755
Dysaesthesia 14.87 13.60 26 118217 2531 42500561
Granulocyte count decreased 14.84 13.60 20 118223 1550 42501542
Device leakage 14.83 13.60 5 118238 10280 42492812
Blister 14.81 13.60 34 118209 27456 42475636
K-ras gene mutation 14.80 13.60 5 118238 30 42503062
Eye infection gonococcal 14.80 13.60 5 118238 30 42503062
Immune-mediated adrenal insuficiency 14.79 13.60 14 118229 735 42502357
Nasal septum perforation 14.76 13.60 9 118234 241 42502851
Musculoskeletal discomfort 14.76 13.60 4 118239 9472 42493620
Aplastic anaemia 14.70 13.60 8 118235 12376 42490716
Butterfly rash 14.65 13.60 7 118236 113 42502979
Labelled drug-drug interaction medication error 14.61 13.60 13 118230 15569 42487523
Mechanical ileus 14.55 13.60 12 118231 524 42502568
Infected neoplasm 14.53 13.60 8 118235 176 42502916
Anorectal discomfort 14.53 13.60 24 118219 2231 42500861
Chimerism 14.50 13.60 9 118234 249 42502843
Hypersplenism 14.49 13.60 12 118231 527 42502565
Hepatitis C 14.48 13.60 5 118238 10128 42492964
Ventricular hypokinesia 14.43 13.60 47 118196 6837 42496255
Laryngeal pain 14.39 13.60 26 118217 2596 42500496
Cytokine release syndrome 14.36 13.60 69 118174 44458 42458634
Genital herpes zoster 14.30 13.60 4 118239 11 42503081
Colon cancer 14.29 13.60 59 118184 9622 42493470
Hypercholesterolaemia 14.26 13.60 9 118234 12840 42490252
Hydronephrosis 14.26 13.60 68 118175 11797 42491295
Catheter site extravasation 14.25 13.60 8 118235 183 42502909
Gait inability 14.20 13.60 26 118217 22807 42480285
Product administration error 14.19 13.60 18 118225 18325 42484767
Metastases to meninges 14.18 13.60 22 118221 1939 42501153
Tracheo-oesophageal fistula 14.16 13.60 12 118231 544 42502548
B-cell small lymphocytic lymphoma 14.09 13.60 8 118235 187 42502905
Breath sounds abnormal 14.08 13.60 8 118235 12085 42491007
Metapneumovirus bronchiolitis 14.05 13.60 4 118239 12 42503080
Pelvic venous thrombosis 14.00 13.60 15 118228 914 42502178
COVID-19 pneumonia 13.99 13.60 24 118219 21589 42481503
Obstruction gastric 13.95 13.60 16 118227 1052 42502040
Diarrhoea haemorrhagic 13.86 13.60 50 118193 7657 42495435
Trismus 13.84 13.60 27 118216 2857 42500235
Acquired tracheo-oesophageal fistula 13.82 13.60 7 118236 129 42502963
Anaphylactic shock 13.78 13.60 112 118131 23405 42479687
Oesophageal irritation 13.72 13.60 6 118237 78 42503014
Portal shunt 13.69 13.60 5 118238 39 42503053
Micturition urgency 13.67 13.60 8 118235 11890 42491202

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neutropenia 4213.56 12.41 4155 188904 370465 110025775
Neuropathy peripheral 3478.60 12.41 2715 190344 176562 110219678
Diarrhoea 2235.43 12.41 5615 187444 1133890 109262350
Disease progression 2227.01 12.41 2424 190635 241610 110154630
Mucosal inflammation 1846.62 12.41 1449 191610 94692 110301548
Dermatitis acneiform 1740.24 12.41 700 192359 11995 110384245
Skin toxicity 1619.60 12.41 651 192408 11132 110385108
Thrombocytopenia 1564.12 12.41 2440 190619 346445 110049795
Arteriospasm coronary 1401.91 12.41 546 192513 8554 110387686
Febrile neutropenia 1362.01 12.41 2174 190885 314593 110081647
Palmar-plantar erythrodysaesthesia syndrome 1162.69 12.41 783 192276 40242 110355998
Malignant neoplasm progression 1156.12 12.41 1473 191586 173094 110223146
Neurotoxicity 1097.77 12.41 764 192295 41443 110354797
Leukopenia 1039.97 12.41 1290 191769 147501 110248739
Metastases to liver 1016.22 12.41 681 192378 34705 110361535
Polyneuropathy 805.66 12.41 568 192491 31444 110364796
Myelosuppression 799.69 12.41 903 192156 93437 110302803
Interstitial lung disease 769.01 12.41 1076 191983 138258 110257982
Neoplasm progression 754.70 12.41 734 192325 63861 110332379
Paronychia 741.57 12.41 370 192689 10711 110385529
Therapy partial responder 635.23 12.41 523 192536 36538 110359702
Nausea 627.94 12.41 3987 189072 1231703 109164537
Gastrointestinal toxicity 626.66 12.41 331 192728 10817 110385423
Cardiotoxicity 618.82 12.41 379 192680 16502 110379738
Metastases to lung 607.82 12.41 421 192638 22642 110373598
Arthralgia 604.25 12.41 304 192755 779328 109616912
Peripheral sensory neuropathy 569.68 12.41 358 192701 16322 110379918
Neutrophil count decreased 555.84 12.41 857 192202 120084 110276156
Joint swelling 553.44 12.41 63 192996 442782 109953458
Bone marrow failure 553.04 12.41 590 192469 57258 110338982
Vomiting 535.87 12.41 3055 190004 907620 109488620
Decreased appetite 518.18 12.41 1915 191144 473931 109922309
Hypomagnesaemia 493.03 12.41 567 192492 59803 110336437
Hyperammonaemia 472.15 12.41 296 192763 13436 110382804
Stomatitis 447.24 12.41 1256 191803 268986 110127254
Headache 442.25 12.41 535 192524 881842 109514398
Rheumatoid arthritis 441.71 12.41 19 193040 299594 110096646
Weight increased 422.69 12.41 106 192953 419538 109976702
Haematotoxicity 413.42 12.41 322 192737 20760 110375480
Systemic lupus erythematosus 412.68 12.41 6 193053 254332 110141908
Anaemia 396.70 12.41 1946 191113 545140 109851100
Product dose omission issue 393.91 12.41 49 193010 321733 110074507
Completed suicide 383.83 12.41 8 193051 242373 110153867
Swelling 381.03 12.41 75 192984 350966 110045274
Proteinuria 368.13 12.41 400 192659 39618 110356622
Sinusitis 363.57 12.41 45 193014 296643 110099597
Abdominal discomfort 362.44 12.41 118 192941 393740 110002500
Enteritis 357.13 12.41 284 192775 18872 110377368
Nasopharyngitis 354.44 12.41 123 192936 394238 110002002
Dehydration 345.90 12.41 1174 191885 278337 110117903
Hypokalaemia 340.82 12.41 887 192172 181561 110214679
Arthropathy 337.14 12.41 50 193009 287472 110108768
Therapeutic product effect decreased 336.77 12.41 23 193036 244293 110151947
Pulmonary embolism 336.39 12.41 978 192081 213496 110182744
Pain 330.77 12.41 737 192322 954218 109442022
Psoriatic arthropathy 326.57 12.41 3 193056 196758 110199482
Pemphigus 325.12 12.41 11 193048 214559 110181681
Wheezing 321.96 12.41 35 193024 255195 110141045
Hyperammonaemic encephalopathy 315.81 12.41 165 192894 5269 110390971
Glossodynia 311.62 12.41 19 193040 221985 110174255
Peripheral swelling 304.32 12.41 163 192896 403871 109992369
Rash pustular 302.86 12.41 219 192840 12610 110383630
Contraindicated product administered 300.89 12.41 39 193020 248228 110148012
Portal hypertension 296.48 12.41 186 192873 8451 110387789
Fall 291.32 12.41 376 192683 603106 109793134
Pyrexia 288.11 12.41 2605 190454 895660 109500580
Helicobacter infection 287.95 12.41 6 193053 181871 110214369
Musculoskeletal stiffness 286.87 12.41 68 192991 279754 110116486
Wound 286.12 12.41 36 193023 234401 110161839
Gastrointestinal perforation 282.49 12.41 171 192888 7285 110388955
Fibromyalgia 281.79 12.41 3 193056 170906 110225334
Intestinal obstruction 281.45 12.41 403 192656 52824 110343416
Drug abuse 280.29 12.41 6 193053 177405 110218835
Colorectal cancer metastatic 279.34 12.41 105 192954 1484 110394756
Asthenia 279.14 12.41 2107 190952 686892 109709348
Blood cholesterol increased 274.67 12.41 11 193048 184774 110211466
Contusion 272.59 12.41 41 193018 233320 110162920
Acute myeloid leukaemia 266.79 12.41 331 192728 37779 110358461
Injury 261.98 12.41 11 193048 177254 110218986
Irritable bowel syndrome 261.64 12.41 5 193054 164210 110232030
Mobility decreased 261.20 12.41 49 193010 237373 110158867
Asthma 256.20 12.41 61 192998 250230 110146010
Pain in extremity 251.38 12.41 288 192771 486830 109909410
Lower respiratory tract infection 251.31 12.41 58 193001 243048 110153192
Depression 250.91 12.41 120 192939 317215 110079025
Hepatic enzyme increased 249.69 12.41 124 192935 320768 110075472
Maternal exposure during pregnancy 247.72 12.41 69 192990 254814 110141426
Acute coronary syndrome 244.62 12.41 249 192810 22863 110373377
Osteoarthritis 243.67 12.41 20 193039 182603 110213637
Type 2 diabetes mellitus 240.42 12.41 18 193041 177214 110219026
Drug hypersensitivity 238.07 12.41 265 192794 453825 109942415
Anxiety 236.16 12.41 156 192903 344922 110051318
Duodenal ulcer perforation 230.22 12.41 22 193037 177678 110218562
Non-cirrhotic portal hypertension 222.72 12.41 73 192986 668 110395572
Chills 215.26 12.41 777 192282 189803 110206437
Metastases to lymph nodes 214.43 12.41 191 192868 14841 110381399
Injection site pain 213.04 12.41 29 193030 177893 110218347
Intentional product use issue 211.38 12.41 84 192975 247822 110148418
Migraine 210.29 12.41 26 193033 171626 110224614
Neutropenic colitis 209.60 12.41 146 192913 7919 110388321
Discomfort 208.85 12.41 58 193001 214649 110181591
Carcinoembryonic antigen increased 205.94 12.41 100 192959 2724 110393516
Blister 204.02 12.41 71 192988 227305 110168935
Arthritis 203.81 12.41 26 193033 167560 110228680
Pericarditis 200.80 12.41 66 192993 219048 110177192
Pneumatosis intestinalis 199.97 12.41 145 192914 8384 110387856
Metastases to peritoneum 198.07 12.41 123 192936 5487 110390753
Intestinal perforation 197.25 12.41 212 192847 20732 110375508
Product use issue 196.14 12.41 154 192905 311541 110084699
Stress cardiomyopathy 194.67 12.41 185 192874 15621 110380619
Insomnia 193.85 12.41 206 192853 360384 110035856
Extravasation 193.62 12.41 115 192944 4730 110391510
Abdominal pain 192.02 12.41 1541 191518 511448 109884792
Oesophageal fistula 190.13 12.41 59 193000 444 110395796
General physical health deterioration 189.30 12.41 1331 191728 423964 109972276
Large intestine perforation 188.58 12.41 186 192873 16443 110379797
Septic shock 187.09 12.41 653 192406 156875 110239365
Portal venous gas 186.88 12.41 59 193000 473 110395767
Urticaria 186.58 12.41 169 192890 318688 110077552
Venoocclusive liver disease 185.41 12.41 177 192882 15030 110381210
C-reactive protein abnormal 185.34 12.41 10 193049 129685 110266555
Ileus 183.91 12.41 247 192812 30482 110365758
Sleep disorder 183.50 12.41 59 193000 198585 110197655
Joint range of motion decreased 181.90 12.41 7 193052 121825 110274415
Acute promyelocytic leukaemia 181.33 12.41 81 192978 1815 110394425
Ascites 181.22 12.41 459 192600 92349 110303891
Bursitis 179.65 12.41 12 193047 129906 110266334
Intentional product misuse 178.83 12.41 14 193045 132890 110263350
Electrocardiogram ST segment elevation 177.61 12.41 139 192920 9021 110387219
Second primary malignancy 177.43 12.41 187 192872 17881 110378359
Drug interaction 176.00 12.41 382 192677 499801 109896439
Memory impairment 175.81 12.41 62 192997 196882 110199358
Drug ineffective 173.32 12.41 1760 191299 1518780 108877460
Hospitalisation 166.44 12.41 25 193034 142468 110253772
Obesity 164.31 12.41 8 193051 113343 110282897
Drug intolerance 164.21 12.41 286 192773 406226 109990014
Posterior reversible encephalopathy syndrome 163.97 12.41 246 192813 33615 110362625
Cholangitis 163.86 12.41 171 192888 16164 110380076
Treatment failure 163.30 12.41 146 192913 277088 110119152
Anastomotic leak 162.90 12.41 68 192991 1284 110394956
Neutropenic sepsis 162.83 12.41 233 192826 30513 110365727
Influenza 160.17 12.41 48 193011 169053 110227187
Metastases to bone 159.22 12.41 233 192826 31139 110365101
Psoriasis 158.03 12.41 27 193032 139966 110256274
Cardiomyopathy 157.29 12.41 240 192819 33285 110362955
Leukoencephalopathy 155.92 12.41 129 192930 9066 110387174
Dizziness 151.74 12.41 665 192394 697528 109698712
Hyperbilirubinaemia 150.20 12.41 224 192835 30447 110365793
Colitis 150.19 12.41 456 192603 101867 110294373
Tumour lysis syndrome 149.48 12.41 224 192835 30577 110365663
Confusional state 147.26 12.41 380 192679 468300 109927940
Sepsis 146.44 12.41 1026 192033 326320 110069920
Intestinal ischaemia 145.78 12.41 160 192899 16019 110380221
Exposure during pregnancy 145.55 12.41 55 193004 167369 110228871
Peritonitis 145.38 12.41 228 192831 32379 110363861
Condition aggravated 143.20 12.41 728 192331 734108 109662132
Device related thrombosis 143.13 12.41 84 192975 3378 110392862
Hiccups 142.33 12.41 142 192917 12727 110383513
Suicide attempt 141.64 12.41 10 193049 103384 110292856
Loss of personal independence in daily activities 141.33 12.41 43 193016 149977 110246263
Night sweats 138.35 12.41 32 193027 133951 110262289
Epistaxis 138.30 12.41 521 192538 129851 110266389
Prescribed overdose 138.16 12.41 3 193056 87578 110308662
Laryngospasm 136.75 12.41 91 192968 4577 110391663
Ejection fraction decreased 136.12 12.41 251 192808 40629 110355611
White blood cell count decreased 135.54 12.41 772 192287 228618 110167622
Chronic obstructive pulmonary disease 135.00 12.41 16 193043 109142 110287098
Administration site extravasation 134.50 12.41 64 192995 1665 110394575
Impaired healing 134.41 12.41 89 192970 196628 110199612
Focal nodular hyperplasia 134.32 12.41 53 193006 860 110395380
Tumour perforation 133.25 12.41 48 193011 597 110395643
Gait inability 132.30 12.41 37 193022 136339 110259901
Lip dry 130.65 12.41 12 193047 100071 110296169
Toxic leukoencephalopathy 129.29 12.41 61 192998 1556 110394684
Stress 128.91 12.41 16 193043 105332 110290908
Grip strength decreased 125.48 12.41 3 193056 80171 110316069
Mucosal toxicity 125.37 12.41 47 193012 659 110395581
Overdose 122.88 12.41 136 192923 233658 110162582
Road traffic accident 122.80 12.41 20 193039 107378 110288862
Paraesthesia 122.64 12.41 865 192194 275656 110120584
Pruritus 122.02 12.41 561 192498 580999 109815241
Splenomegaly 121.51 12.41 180 192879 24318 110371922
Subileus 121.19 12.41 96 192963 6341 110389899
Suicidal ideation 120.67 12.41 12 193047 93925 110302315
Skin reaction 120.53 12.41 166 192893 20978 110375262
Nodular regenerative hyperplasia 119.67 12.41 58 193001 1573 110394667
Deep vein thrombosis 118.19 12.41 521 192538 139366 110256874
Azotaemia 116.58 12.41 114 192945 9971 110386269
Tumour necrosis 116.51 12.41 65 192994 2371 110393869
Red blood cell sedimentation rate increased 115.20 12.41 5 193054 78297 110317943
Cholinergic syndrome 115.03 12.41 53 193006 1279 110394961
Hypoalbuminaemia 114.75 12.41 192 192867 28782 110367458
Enterocolitis 114.44 12.41 153 192906 18796 110377444
Injection site reaction 112.81 12.41 12 193047 89058 110307182
Device related infection 112.41 12.41 227 192832 39292 110356948
Aortic thrombosis 111.97 12.41 61 192998 2122 110394118
Gastrointestinal anastomotic leak 111.00 12.41 44 193015 723 110395517
Sciatica 110.73 12.41 15 193044 92384 110303856
Gastrooesophageal reflux disease 110.56 12.41 91 192968 179885 110216355
Gastrointestinal necrosis 110.19 12.41 92 192967 6548 110389692
Ill-defined disorder 108.45 12.41 70 192989 156783 110239457
Somnolence 108.00 12.41 223 192836 297226 110099014
Dermatitis 106.97 12.41 182 192877 27655 110368585
Pancytopenia 106.31 12.41 678 192381 208935 110187305
Bronchitis 105.98 12.41 72 192987 156960 110239280
Hypercholesterolaemia 105.93 12.41 16 193043 90821 110305419
Intravascular haemolysis 105.06 12.41 46 193013 981 110395259
Small intestinal obstruction 105.01 12.41 196 192863 32017 110364223
Fluid retention 104.66 12.41 19 193040 94288 110301952
Embolism 103.74 12.41 135 192924 16154 110380086
Left ventricular dysfunction 102.97 12.41 163 192896 23330 110372910
Peripheral venous disease 102.37 12.41 13 193046 84104 110312136
Rhabdomyolysis 102.25 12.41 41 193018 120360 110275880
Metastasis 100.36 12.41 96 192963 8171 110388069
Musculoskeletal pain 100.03 12.41 103 192956 182920 110213320
Large intestinal obstruction 99.81 12.41 70 192989 3838 110392402
Feeling abnormal 98.42 12.41 102 192957 180609 110215631
Injection site erythema 98.21 12.41 22 193037 94154 110302086
Pneumonia 94.44 12.41 1027 192032 875687 109520553
Live birth 94.37 12.41 7 193052 69477 110326763
Disseminated intravascular coagulation 94.31 12.41 217 192842 41069 110355171
Conjunctivitis 93.62 12.41 192 192867 33600 110362640
Febrile bone marrow aplasia 93.42 12.41 133 192926 17332 110378908
Pelvic abscess 93.38 12.41 58 193001 2588 110393652
Gait disturbance 93.23 12.41 218 192841 277990 110118250
Drug reaction with eosinophilia and systemic symptoms 92.28 12.41 16 193043 82079 110314161
Muscle spasms 91.59 12.41 220 192839 277937 110118303
Oesophagitis 91.46 12.41 173 192886 28542 110367698
Dysphagia 91.38 12.41 518 192541 153082 110243158
Hypertransaminasaemia 91.12 12.41 157 192902 24098 110372142
Prescribed underdose 90.15 12.41 6 193053 65168 110331072
Incorrect dose administered 90.15 12.41 34 193025 103607 110292633
Serotonin syndrome 89.68 12.41 3 193056 59150 110337090
Aorto-oesophageal fistula 89.67 12.41 23 193036 76 110396164
Adverse drug reaction 89.55 12.41 36 193023 105523 110290717
Congestive cardiomyopathy 87.70 12.41 116 192943 14103 110382137
COVID-19 87.04 12.41 186 192873 244874 110151366
Adverse event 86.15 12.41 41 193018 108768 110287472
Nasal congestion 85.89 12.41 32 193027 98250 110297990
Vasospasm 85.77 12.41 46 193013 1550 110394690
Recall phenomenon 85.75 12.41 44 193015 1352 110394888
Rectal perforation 85.63 12.41 40 193019 997 110395243
Product quality issue 84.86 12.41 16 193043 77283 110318957
Trichomegaly 84.85 12.41 24 193035 125 110396115
Carbohydrate antigen 19-9 increased 84.34 12.41 33 193026 523 110395717
Sedation 84.24 12.41 11 193048 69672 110326568
Dysgeusia 83.80 12.41 291 192768 69694 110326546
Immune thrombocytopenia 83.71 12.41 145 192914 22349 110373891
Oesophageal stenosis 82.49 12.41 70 192989 5095 110391145
Hepatic lesion 81.79 12.41 87 192972 8406 110387834
Myalgia 81.32 12.41 166 192893 222215 110174025
Liver abscess 81.20 12.41 83 192976 7656 110388584
Skin disorder 79.37 12.41 208 192851 42705 110353535
Injection site swelling 79.08 12.41 8 193051 61782 110334458
Hypophagia 78.58 12.41 236 192823 52390 110343850
Venous thrombosis 78.17 12.41 85 192974 8420 110387820
Ear infection 78.05 12.41 9 193050 62723 110333517
Skin fissures 77.46 12.41 147 192912 24311 110371929
Hepatic failure 77.31 12.41 280 192779 68459 110327781
Pneumonitis 77.16 12.41 301 192758 76230 110320010
Folliculitis 77.10 12.41 108 192951 167545 110228695
Hyperthermia 76.41 12.41 135 192924 21137 110375103
Injection site bruising 76.32 12.41 3 193056 51260 110344980
Upper respiratory tract infection 76.28 12.41 70 192989 131258 110264982
Dihydropyrimidine dehydrogenase deficiency 76.06 12.41 24 193035 192 110396048
Electrocardiogram QT prolonged 74.81 12.41 49 193010 108911 110287329
Vena cava thrombosis 74.27 12.41 56 193003 3438 110392802
Ileal perforation 74.26 12.41 40 193019 1360 110394880
Xeroderma 73.94 12.41 31 193028 592 110395648
Ocular toxicity 73.13 12.41 39 193020 1299 110394941
Osteoporosis 71.87 12.41 31 193028 87121 110309119
Amnesia 71.56 12.41 48 193011 105360 110290880
Joint stiffness 71.55 12.41 15 193044 67228 110329012
Medication error 71.51 12.41 48 193011 105318 110290922
Sleep disorder due to a general medical condition 71.49 12.41 5 193054 52107 110344133
Varices oesophageal 71.42 12.41 75 192984 7140 110389100
Illness 71.39 12.41 27 193032 82144 110314096
Blood pressure fluctuation 71.27 12.41 21 193038 74803 110321437
Inappropriate schedule of product administration 71.11 12.41 156 192903 203481 110192759
Metastases to central nervous system 70.86 12.41 136 192923 22681 110373559
Oesophageal varices haemorrhage 70.86 12.41 63 192996 4882 110391358
Stoma site haemorrhage 70.85 12.41 47 193012 2351 110393889
Heart rate decreased 70.56 12.41 28 193031 82728 110313512
Aggression 70.03 12.41 10 193049 59200 110337040
Necrotising fasciitis 70.00 12.41 76 192983 7515 110388725
Enterocutaneous fistula 69.78 12.41 46 193013 2277 110393963
Pregnancy 69.76 12.41 5 193054 51062 110345178
Colony stimulating factor therapy 69.74 12.41 30 193029 612 110395628
Hepatectomy 69.25 12.41 25 193034 313 110395927
Portal vein thrombosis 69.21 12.41 73 192986 6985 110389255
Colon cancer metastatic 69.06 12.41 47 193012 2454 110393786
Toxic erythema of chemotherapy 68 12.41 26 193033 386 110395854
Cough 67.95 12.41 499 192560 461142 109935098
Neck pain 67.60 12.41 69 192990 123061 110273179
Oesophagobronchial fistula 66.56 12.41 23 193036 251 110395989
Dysarthria 66.31 12.41 307 192752 83814 110312426
Colitis ulcerative 66.25 12.41 26 193033 77337 110318903
Aortitis 65.68 12.41 42 193017 1973 110394267
Thrombocytopenic purpura 65.24 12.41 49 193010 2990 110393250
Hallucination 65.16 12.41 49 193010 101383 110294857
Platelet count decreased 64.80 12.41 651 192408 229792 110166448
Liver function test increased 64.71 12.41 37 193022 88511 110307729
Blood pressure systolic increased 64.59 12.41 32 193027 82959 110313281
Anastomotic complication 64.56 12.41 28 193031 583 110395657
Adenocarcinoma 64.27 12.41 56 193003 4224 110392016
Infusion related reaction 64.08 12.41 396 192663 380766 110015474
Dysentery 63.99 12.41 36 193023 1335 110394905
Hypovolaemic shock 63.66 12.41 101 192958 14482 110381758
Cutaneous lupus erythematosus 63.49 12.41 51 193008 3437 110392803
Steatohepatitis 63.41 12.41 35 193024 1250 110394990
Blepharospasm 63.18 12.41 10 193049 54841 110341399
Metastases to skin 62.99 12.41 43 193016 2256 110393984
Foot deformity 62.77 12.41 6 193053 48474 110347766
Anastomotic fistula 62.17 12.41 19 193040 135 110396105
Nicotinic acid deficiency 61.97 12.41 21 193038 215 110396025
Encephalopathy 61.83 12.41 293 192766 80762 110315478
Haemolytic anaemia 61.69 12.41 122 192937 20798 110375442
Dry skin 61.37 12.41 359 192700 107294 110288946
Rectal tenesmus 61.25 12.41 42 193017 2220 110394020
Cardiomyopathy acute 61.25 12.41 24 193035 382 110395858
Bacterial translocation 61.15 12.41 36 193023 1456 110394784
Prinzmetal angina 61.13 12.41 42 193017 2227 110394013
Acute abdomen 60.87 12.41 49 193010 3312 110392928
Rectal cancer metastatic 60.68 12.41 26 193033 525 110395715
Odynophagia 60.65 12.41 97 192962 14004 110382236
Subacute cutaneous lupus erythematosus 60.64 12.41 58 193001 4936 110391304
Muscular weakness 60.53 12.41 226 192833 248242 110147998
Oesophageal perforation 60.16 12.41 37 193022 1622 110394618
Electrolyte imbalance 60.02 12.41 171 192888 36857 110359383
Gastric perforation 59.38 12.41 57 193002 4872 110391368
Subclavian vein thrombosis 59.33 12.41 45 193014 2787 110393453
Jugular vein thrombosis 59.15 12.41 59 193000 5286 110390954
Adenocarcinoma of colon 59.07 12.41 63 192996 6105 110390135
Lymphangiosis carcinomatosa 57.74 12.41 42 193017 2440 110393800
Dislocation of vertebra 57.71 12.41 5 193054 43716 110352524
Plasma cell myeloma 57.55 12.41 19 193040 62917 110333323
Cachexia 56.67 12.41 90 192969 12915 110383325
Nephrotic syndrome 56.57 12.41 93 192966 13738 110382502
Immune-mediated hepatic disorder 56.55 12.41 53 193006 4397 110391843
Monocyte chemotactic protein-1 increased 56.38 12.41 22 193037 346 110395894
Pulmonary artery thrombosis 56.24 12.41 35 193024 1567 110394673
Fistula 56.12 12.41 98 192961 15201 110381039
Aplasia 56.08 12.41 69 192990 7804 110388436
Back injury 56.07 12.41 8 193051 47391 110348849
Duodenal perforation 55.80 12.41 43 193016 2727 110393513
Onychomadesis 55.70 12.41 7 193052 45656 110350584
Accidental exposure to product 55.65 12.41 10 193049 49998 110346242
Proctalgia 55.56 12.41 90 192969 13132 110383108
Hypertensive crisis 55.55 12.41 128 192931 24244 110371996
Sleep apnoea syndrome 55.14 12.41 4 193055 40443 110355797
Malignant ascites 55.12 12.41 33 193026 1377 110394863
Metastases to ovary 54.60 12.41 22 193037 378 110395862
Alpha tumour necrosis factor increased 53.97 12.41 22 193037 390 110395850
Breast cancer metastatic 53.80 12.41 81 192978 11100 110385140
Growth of eyelashes 53.58 12.41 18 193041 179 110396061
Small intestinal perforation 53.47 12.41 51 193008 4325 110391915
Radiation skin injury 53.15 12.41 34 193025 1598 110394642
Blood pressure increased 53.04 12.41 251 192808 258122 110138118
Lupus-like syndrome 52.94 12.41 5 193054 40787 110355453
Therapy non-responder 52.88 12.41 123 192936 157184 110239056
Agranulocytosis 52.88 12.41 231 192828 61529 110334711
Xerosis 52.83 12.41 34 193025 1615 110394625
Drug ineffective for unapproved indication 52.72 12.41 61 192998 102777 110293463
Balance disorder 52.68 12.41 76 192983 116484 110279756
No adverse event 52.34 12.41 32 193027 73807 110322433
Emotional distress 52.06 12.41 8 193051 44839 110351401
Visual impairment 52.03 12.41 97 192962 134331 110261909
Hypoaesthesia 52.00 12.41 328 192731 313895 110082345
Pulmonary toxicity 51.74 12.41 103 192956 17643 110378597
Joint injury 51.65 12.41 5 193054 39989 110356251
Pulmonary ossification 51.54 12.41 14 193045 61 110396179
Biliary tract infection 51.45 12.41 34 193025 1690 110394550
Systemic infection 51.38 12.41 74 192985 9745 110386495
Treatment noncompliance 51.23 12.41 32 193027 72958 110323282
Colon cancer recurrent 51.15 12.41 16 193043 124 110396116
Conjunctival filtering bleb leak 51.09 12.41 12 193047 24 110396216
Tumour haemorrhage 50.99 12.41 54 193005 5191 110391049
Muscle spasticity 50.59 12.41 3 193056 35912 110360328
Type II hypersensitivity 50.57 12.41 15 193044 95 110396145
Bradycardia 50.38 12.41 124 192935 155393 110240847
Laryngeal oedema 49.99 12.41 73 192986 9734 110386506
Stomal varices 49.45 12.41 16 193043 140 110396100
Incorrect route of product administration 49.40 12.41 25 193034 64036 110332204
Neoplasm recurrence 49.33 12.41 53 193006 5179 110391061
Ischaemic stroke 48.89 12.41 171 192888 41092 110355148
Heart rate increased 48.72 12.41 112 192947 143722 110252518
Underdose 48.71 12.41 25 193034 63529 110332711
Drug withdrawal syndrome 48.51 12.41 5 193054 38049 110358191
Metastases to meninges 48.44 12.41 52 193007 5076 110391164
Organising pneumonia 48.10 12.41 88 192971 14155 110382085
Tremor 47.92 12.41 186 192873 202046 110194194
Dysphonia 47.76 12.41 260 192799 75669 110320571
Joint dislocation 47.72 12.41 3 193056 34187 110362053
Gastrointestinal stoma complication 47.32 12.41 42 193017 3247 110392993
Dry mouth 47.31 12.41 184 192875 199764 110196476
Depilation 46.93 12.41 12 193047 39 110396201
Drug level increased 46.17 12.41 13 193046 47706 110348534
Erythema 46.15 12.41 740 192319 290707 110105533
Full blood count abnormal 46.11 12.41 20 193039 56032 110340208
Encapsulating peritoneal sclerosis 46.06 12.41 25 193034 863 110395377
Hypocalcaemia 46.06 12.41 231 192828 65135 110331105
Toxic cardiomyopathy 45.97 12.41 24 193035 765 110395475
Metastases to pleura 45.94 12.41 34 193025 2029 110394211
Acral peeling skin syndrome 45.82 12.41 12 193047 44 110396196
Infection 45.69 12.41 408 192651 361792 110034448
Eosinophilia 45.60 12.41 22 193037 57914 110338326
Tumour marker increased 45.51 12.41 50 193009 5010 110391230
Abdominal abscess 45.47 12.41 66 192993 8753 110387487
Sinus disorder 45.30 12.41 3 193056 32725 110363515
Nephrolithiasis 45.14 12.41 30 193029 66182 110330058
Productive cough 44.66 12.41 82 192977 114223 110282017
Respiratory arrest 44.58 12.41 23 193036 58276 110337964
Wound infection 44.48 12.41 62 192997 96403 110299837
Troponin I increased 44.13 12.41 51 193008 5401 110390839
Ventricular hypokinesia 43.98 12.41 74 192985 11140 110385100
Superior vena cava syndrome 43.83 12.41 28 193031 1313 110394927
Oedema 43.67 12.41 203 192856 209773 110186467
Viral infection 43.65 12.41 19 193040 53120 110343120
Metastases to chest wall 43.54 12.41 22 193037 654 110395586
Palpitations 43.37 12.41 138 192921 159074 110237166
Cholestasis 43.36 12.41 225 192834 64293 110331947
Withdrawal syndrome 43.07 12.41 3 193056 31377 110364863
Performance status decreased 42.85 12.41 58 193001 7208 110389032
Myocarditis 42.27 12.41 132 192927 29923 110366317
Therapy interrupted 42.24 12.41 17 193042 49805 110346435
Papilloedema 41.97 12.41 58 193001 7351 110388889
Transdifferentiation of neoplasm 41.87 12.41 13 193046 98 110396142
Enterovesical fistula 41.78 12.41 28 193031 1425 110394815
Tumour ulceration 41.73 12.41 17 193042 301 110395939
Frequent bowel movements 41.51 12.41 38 193021 71352 110324888
Immune-mediated renal disorder 41.47 12.41 22 193037 725 110395515
Liver injury 41.23 12.41 130 192929 150283 110245957
Disability 41.17 12.41 3 193056 30220 110366020
Balanoposthitis 40.73 12.41 27 193032 1349 110394891
Renal salt-wasting syndrome 40.59 12.41 23 193036 865 110395375
Injection site haemorrhage 40.44 12.41 5 193054 33023 110363217
Wrong technique in product usage process 40.41 12.41 56 193003 87292 110308948
Acute respiratory distress syndrome 40.35 12.41 192 192867 53006 110343234
Oral pain 39.98 12.41 150 192909 37294 110358946
Pelvic fluid collection 39.93 12.41 24 193035 1009 110395231
Chronic myeloid leukaemia 39.79 12.41 43 193016 4230 110392010
Cystitis 39.78 12.41 34 193025 66002 110330238
Diaphragmatic paralysis 39.78 12.41 26 193033 1268 110394972
Pancreatic neuroendocrine tumour metastatic 39.77 12.41 15 193044 214 110396026
Pseudocirrhosis 39.76 12.41 23 193036 900 110395340
Blood glucose increased 39.58 12.41 110 192949 132386 110263854
Respiratory tract congestion 39.47 12.41 4 193055 30853 110365387
Vision blurred 39.38 12.41 106 192953 128916 110267324
Lung neoplasm malignant 39.36 12.41 6 193053 33836 110362404
Poisoning 39.33 12.41 3 193056 29102 110367138
Haemolytic uraemic syndrome 39.30 12.41 46 193013 4939 110391301
Rib fracture 39.25 12.41 6 193053 33764 110362476
Delirium 38.94 12.41 114 192945 134911 110261329
Inflammation 38.90 12.41 189 192870 193049 110203191
Unevaluable event 38.83 12.41 28 193031 59199 110337041
Cataract 38.78 12.41 49 193010 79436 110316804
Oesophageal-pulmonary fistula 38.33 12.41 10 193049 36 110396204
UGT1A1 gene mutation 38.32 12.41 9 193050 18 110396222
Thrombotic microangiopathy 38.24 12.41 125 192934 29024 110367216
Acute kidney injury 38.23 12.41 1412 191647 634018 109762222
Gene mutation 38.22 12.41 38 193021 3391 110392849
Diffuse alveolar damage 38.16 12.41 41 193018 4006 110392234
Evans syndrome 38.02 12.41 21 193038 751 110395489
Metastatic neoplasm 37.91 12.41 49 193010 5824 110390416
Dysaesthesia 37.89 12.41 53 193006 6794 110389446
Stridor 37.60 12.41 53 193006 6842 110389398
Immune-mediated myocarditis 37.58 12.41 38 193021 3460 110392780
Venous thrombosis limb 37.27 12.41 46 193013 5219 110391021
Hepatitis B 37.13 12.41 63 192996 9549 110386691
Gastrointestinal obstruction 37.09 12.41 31 193028 2209 110394031
Guillain-Barre syndrome 37.07 12.41 67 192992 10677 110385563
Respiratory disorder 36.95 12.41 42 193017 71340 110324900
Interleukin level increased 36.73 12.41 27 193032 1594 110394646
Fistula of small intestine 36.52 12.41 23 193036 1052 110395188
Sneezing 36.46 12.41 6 193053 31978 110364262
Panic attack 36.38 12.41 4 193055 28936 110367304
Onychomycosis 36.36 12.41 11 193048 38520 110357720
Anal haemorrhage 36.25 12.41 44 193015 4908 110391332
Systemic scleroderma 36.25 12.41 29 193030 1943 110394297
Psychotic disorder 36.21 12.41 22 193037 50915 110345325
Accidental overdose 36.00 12.41 23 193036 51811 110344429
Ovarian failure 35.98 12.41 22 193037 954 110395286
Head injury 35.95 12.41 15 193044 43002 110353238
Blood alkaline phosphatase increased 35.65 12.41 229 192830 70706 110325534
Jaundice 35.36 12.41 200 192859 59036 110337204
Eastern Cooperative Oncology Group performance status worsened 35.14 12.41 34 193025 2935 110393305
Anaphylactoid reaction 35.07 12.41 51 193008 6775 110389465
Oesophageal haemorrhage 35.01 12.41 28 193031 1875 110394365
Onycholysis 34.92 12.41 33 193026 2766 110393474
Disturbance in attention 34.87 12.41 34 193025 61961 110334279
Metastases to the mediastinum 34.80 12.41 20 193039 773 110395467
Abdominal infection 34.57 12.41 42 193017 4689 110391551
Cardiac failure congestive 34.42 12.41 141 192918 150859 110245381
Pleural effusion 34.30 12.41 467 192592 177242 110218998
Ventricular dysfunction 34.14 12.41 53 193006 7458 110388782
Sinus congestion 34.09 12.41 6 193053 30453 110365787
Incorrect drug administration rate 34.07 12.41 45 193014 5463 110390777
Right ventricular ejection fraction decreased 34.03 12.41 10 193049 61 110396179
Leukocytosis 33.63 12.41 184 192875 53644 110342596
K-ras gene mutation 33.62 12.41 10 193049 64 110396176
Anorectal disorder 33.42 12.41 32 193027 2727 110393513
Gastric stenosis 33.28 12.41 13 193046 205 110396035
Pharyngeal inflammation 33.21 12.41 26 193033 1688 110394552
Protein urine 33.21 12.41 25 193034 1531 110394709
White blood cell count abnormal 33.17 12.41 50 193009 6859 110389381
Lung disorder 32.92 12.41 182 192877 179865 110216375
Chronic sinusitis 32.75 12.41 3 193056 25081 110371159
Myelodysplastic syndrome 32.69 12.41 141 192918 37343 110358897
Poor quality sleep 32.61 12.41 5 193054 28072 110368168
Therapy cessation 32.41 12.41 19 193040 44838 110351402
Herpes zoster 32.36 12.41 90 192969 108289 110287951
Irritability 32.14 12.41 22 193037 47787 110348453
Peripheral sensorimotor neuropathy 32.11 12.41 37 193022 3906 110392334
Thrombotic thrombocytopenic purpura 32.08 12.41 50 193009 7061 110389179
Laryngitis 32.03 12.41 17 193042 42394 110353846
Nasal septum perforation 31.97 12.41 20 193039 904 110395336
Capillary leak syndrome 31.76 12.41 41 193018 4867 110391373
Sopor 31.76 12.41 12 193047 36534 110359706
Adenocarcinoma metastatic 31.71 12.41 15 193044 385 110395855
Ileus paralytic 31.70 12.41 66 192993 11671 110384569
Splenic artery thrombosis 31.69 12.41 10 193049 80 110396160
Bronchiectasis 31.68 12.41 12 193047 36481 110359759
Limb injury 31.65 12.41 13 193046 37623 110358617
Disease recurrence 31.64 12.41 198 192861 60586 110335654
Epilepsy 31.59 12.41 81 192978 100128 110296112
Radiation mucositis 31.53 12.41 14 193045 309 110395931
International normalised ratio increased 31.51 12.41 65 192994 86707 110309533
Perineal disorder 31.49 12.41 9 193050 49 110396191
Peritoneal disorder 31.43 12.41 19 193040 807 110395433
Astringent therapy 31.29 12.41 8 193051 26 110396214
Multiple sclerosis 31.20 12.41 4 193055 25694 110370546
Venous pressure jugular decreased 31.16 12.41 10 193049 85 110396155
Hypercreatinaemia 31.01 12.41 15 193044 405 110395835
Foot fracture 30.96 12.41 4 193055 25542 110370698
Dermatitis atopic 30.95 12.41 4 193055 25537 110370703
Insulin autoimmune syndrome 30.67 12.41 18 193041 724 110395516
Necrosis 30.64 12.41 64 192995 11342 110384898
Cardiogenic shock 30.61 12.41 188 192871 57150 110339090
Tongue oedema 30.43 12.41 53 193006 8203 110388037
Pancreatic carcinoma recurrent 30.40 12.41 12 193047 195 110396045
Infectious pleural effusion 30.31 12.41 40 193019 4851 110391389
Walking aid user 30.21 12.41 4 193055 25071 110371169
Agitation 30.08 12.41 99 192960 112952 110283288
Injection site rash 30.05 12.41 3 193056 23416 110372824
Localised infection 30.03 12.41 19 193040 43029 110353211
Obstructive airways disorder 30.02 12.41 22 193037 46127 110350113
Movement disorder 29.93 12.41 13 193046 36391 110359849
Short-bowel syndrome 29.92 12.41 18 193041 758 110395482
Cardiac ventricular thrombosis 29.88 12.41 32 193027 3115 110393125
Eye pruritus 29.78 12.41 10 193049 32765 110363475
Respiratory alkalosis 29.77 12.41 43 193016 5678 110390562
Renal failure 29.62 12.41 558 192501 226016 110170224
Extrapyramidal disorder 29.58 12.41 7 193052 28860 110367380
Injection site mass 29.48 12.41 4 193055 24609 110371631
Cytomegalovirus infection 29.32 12.41 31 193028 54413 110341827
Hepatic atrophy 29.32 12.41 15 193044 458 110395782
Bacteraemia 29.30 12.41 149 192910 42241 110353999
Acute myocardial infarction 29.25 12.41 248 192811 83529 110312711
Anal erythema 29.24 12.41 13 193046 288 110395952
Wound dehiscence 29.20 12.41 51 193008 7911 110388329
Hypervolaemia 29.15 12.41 26 193033 49434 110346806
Cellulitis 29.14 12.41 117 192942 125899 110270341
C-reactive protein increased 29.01 12.41 242 192817 217677 110178563
Xerophthalmia 28.97 12.41 19 193040 932 110395308
Abnormal behaviour 28.97 12.41 16 193043 39023 110357217
Blood creatine phosphokinase increased 28.92 12.41 52 193007 73025 110323215
Neutrophil count abnormal 28.81 12.41 40 193019 5092 110391148
Colon cancer 28.68 12.41 78 192981 16365 110379875
Hypoglycaemia 28.65 12.41 105 192954 115999 110280241
Duodenal ulcer 28.65 12.41 87 192972 19427 110376813
Mental disorder 28.64 12.41 16 193043 38775 110357465
Prostate cancer 28.56 12.41 15 193044 37626 110358614
Pneumoperitoneum 28.51 12.41 35 193024 3949 110392291
Arterial thrombosis 28.37 12.41 31 193028 3088 110393152
Cytomegalovirus oesophagitis 28.35 12.41 19 193040 967 110395273
Anorectal varices haemorrhage 28.31 12.41 7 193052 19 110396221
Necrotising oesophagitis 28.29 12.41 23 193036 1577 110394663
Therapeutic response unexpected 28.26 12.41 4 193055 23839 110372401
Lewis-Sumner syndrome 28.20 12.41 9 193050 75 110396165
Rash pruritic 28.13 12.41 83 192976 97986 110298254
Pulmonary veno-occlusive disease 28.10 12.41 26 193033 2122 110394118
Parkinsonism 28.06 12.41 3 193056 22184 110374056
Sciatic nerve palsy 27.99 12.41 9 193050 77 110396163
Sudden death 27.96 12.41 100 192959 24295 110371945
Breast cancer recurrent 27.87 12.41 34 193025 3812 110392428
Metastases to bone marrow 27.87 12.41 19 193040 995 110395245
Cystitis radiation 27.84 12.41 12 193047 246 110395994
Cardiac disorder 27.81 12.41 57 193002 76223 110320017
Portal vein embolisation 27.80 12.41 7 193052 21 110396219
Musculoskeletal discomfort 27.78 12.41 4 193055 23534 110372706
Infusion related hypersensitivity reaction 27.74 12.41 18 193041 867 110395373
Hip arthroplasty 27.65 12.41 34 193025 55779 110340461
Nephritis bacterial 27.48 12.41 8 193051 47 110396193
Hepatic function abnormal 27.40 12.41 257 192802 89038 110307202
NPM1 gene mutation 27.36 12.41 10 193049 130 110396110
Immunodeficiency 27.29 12.41 17 193042 38821 110357419
Macular degeneration 27.21 12.41 3 193056 21656 110374584
Rectal adenocarcinoma 27.20 12.41 23 193036 1666 110394574
Transplant rejection 27.15 12.41 5 193054 24562 110371678
Miller Fisher syndrome 27.12 12.41 13 193046 344 110395896
Portal shunt 27.11 12.41 9 193050 86 110396154
Diarrhoea haemorrhagic 27.09 12.41 74 192985 15565 110380675
Granulocyte count decreased 26.98 12.41 34 193025 3940 110392300
Electrocardiogram ST segment depression 26.90 12.41 40 193019 5421 110390819
Mixed adenoneuroendocrine carcinoma 26.87 12.41 7 193052 25 110396215
Fixed eruption 26.83 12.41 35 193024 4197 110392043
Dyspepsia 26.83 12.41 209 192850 190756 110205484
Mood altered 26.76 12.41 3 193056 21372 110374868
Hydronephrosis 26.55 12.41 88 192971 20577 110375663
Hormone receptor positive breast cancer 26.52 12.41 15 193044 562 110395678
Eye pain 26.46 12.41 29 193030 50070 110346170
Microangiopathic haemolytic anaemia 26.35 12.41 24 193035 1919 110394321
Ventricular fibrillation 26.34 12.41 142 192917 41171 110355069
Left ventricular dilatation 26.32 12.41 21 193038 1401 110394839
Dyspnoea 26.27 12.41 1624 191435 1105248 109290992
Hyperpyrexia 26.17 12.41 49 193010 8020 110388220
Gastric ischaemia 26.16 12.41 8 193051 57 110396183
Myocardial ischaemia 26.12 12.41 104 192955 26580 110369660
VIth nerve disorder 26.05 12.41 7 193052 29 110396211
Cytopenia 26.05 12.41 113 192946 30003 110366237
Pharyngeal dyskinesia 26.04 12.41 8 193051 58 110396182
Factor VII deficiency 25.98 12.41 9 193050 99 110396141
Perforation 25.82 12.41 23 193036 1787 110394453
Pulmonary infarction 25.81 12.41 34 193025 4117 110392123
Bone marrow oedema syndrome 25.80 12.41 8 193051 60 110396180
Induration 25.75 12.41 26 193033 2363 110393877
Product prescribing error 25.71 12.41 31 193028 51300 110344940
Rectal cancer recurrent 25.69 12.41 8 193051 61 110396179
Laryngeal pain 25.56 12.41 41 193018 5934 110390306
Neuromyotonia 25.50 12.41 9 193050 105 110396135
Diaphragmatic operation 25.50 12.41 7 193052 32 110396208
Back pain 25.46 12.41 475 192584 370521 110025719
Angina pectoris 25.34 12.41 191 192868 62104 110334136
Miosis 25.34 12.41 4 193055 21979 110374261
Adverse reaction 25.25 12.41 10 193049 29584 110366656
Swelling face 25.15 12.41 80 192979 92241 110303999
Ectropion 24.96 12.41 14 193045 516 110395724
Product storage error 24.94 12.41 4 193055 21724 110374516
Cell-mediated cytotoxicity 24.93 12.41 8 193051 68 110396172
Hypoferritinaemia 24.92 12.41 6 193053 14 110396226
Tracheal stenosis 24.84 12.41 15 193044 636 110395604
Immune-mediated dermatitis 24.83 12.41 25 193034 2265 110393975
Dyskinesia 24.80 12.41 32 193027 51414 110344826
Portal hypertensive gastropathy 24.77 12.41 23 193036 1885 110394355
Wrong rate 24.76 12.41 10 193049 173 110396067
Liver function test abnormal 24.74 12.41 52 193007 68898 110327342
Oedema peripheral 24.72 12.41 414 192645 328246 110067994
Kidney infection 24.72 12.41 7 193052 25592 110370648
Eczema 24.71 12.41 56 193003 72237 110324003
Gastrointestinal ischaemia 24.69 12.41 14 193045 527 110395713
Limb discomfort 24.65 12.41 21 193038 40833 110355407
Blood creatine increased 24.61 12.41 59 193000 11462 110384778
Oesophageal carcinoma recurrent 24.52 12.41 8 193051 72 110396168
Toxic skin eruption 24.38 12.41 104 192955 27411 110368829
PIK3CA-activated mutation 24.38 12.41 15 193044 658 110395582
Angioedema 24.36 12.41 89 192970 98411 110297829
Gastroenteritis radiation 24.27 12.41 16 193043 792 110395448
Musculoskeletal disorder 24.23 12.41 5 193054 22659 110373581
Anal erosion 24.14 12.41 8 193051 76 110396164
Koebner phenomenon 24.05 12.41 8 193051 77 110396163
Dysaesthesia pharynx 24.05 12.41 11 193048 261 110395979
Lymphadenopathy mediastinal 23.96 12.41 38 193021 5446 110390794
Constipation 23.94 12.41 805 192254 356981 110039259
Cardiac failure 23.81 12.41 460 192599 187166 110209074
Myoclonus 23.81 12.41 14 193045 32984 110363256
Ear pain 23.75 12.41 35 193024 53191 110343049
Dry eye 23.64 12.41 38 193021 55755 110340485
Skin hyperpigmentation 23.60 12.41 49 193010 8647 110387593
Faecaluria 23.59 12.41 6 193053 19 110396221
Intracardiac thrombus 23.56 12.41 33 193026 4235 110392005
Hypercreatininaemia 23.53 12.41 19 193040 1290 110394950
Product dose omission in error 23.51 12.41 6 193053 23506 110372734
Metastases to pelvis 23.50 12.41 16 193043 836 110395404
Toxic encephalopathy 23.44 12.41 69 192990 15145 110381095
Hepatic cirrhosis 23.43 12.41 52 193007 67574 110328666
Embolism arterial 23.35 12.41 22 193037 1837 110394403
Nasal crusting 23.35 12.41 16 193043 845 110395395
Metastases to spine 23.31 12.41 37 193022 5306 110390934
Cardiac murmur 23.29 12.41 7 193052 24621 110371619
Restless legs syndrome 23.29 12.41 7 193052 24619 110371621
Post procedural diarrhoea 23.23 12.41 13 193046 477 110395763
Diabetes mellitus 23.15 12.41 92 192967 99289 110296951
Hypersomnia 23.10 12.41 10 193049 28051 110368189
Haemoglobinuria 23.08 12.41 16 193043 861 110395379
Procedural pain 23.07 12.41 17 193042 35548 110360692
Immune-mediated adverse reaction 23.06 12.41 21 193038 1679 110394561
Altered state of consciousness 23.06 12.41 176 192883 57450 110338790
Gout 23.05 12.41 18 193041 36548 110359692
Anger 22.97 12.41 3 193056 19004 110377236
Cutaneous symptom 22.95 12.41 16 193043 869 110395371
Biliary fistula 22.92 12.41 9 193050 144 110396096
Necrosis ischaemic 22.90 12.41 19 193040 1340 110394900
Renal impairment 22.90 12.41 459 192600 187986 110208254
Atypical haemolytic uraemic syndrome 22.83 12.41 20 193039 1520 110394720
Recurrent cancer 22.79 12.41 29 193030 3394 110392846
Fingerprint loss 22.77 12.41 8 193051 92 110396148
Rectal haemorrhage 22.75 12.41 314 192745 119519 110276721
Laboratory test abnormal 22.75 12.41 26 193033 44053 110352187
Aortic dissection 22.69 12.41 35 193024 4898 110391342
Immune-mediated enterocolitis 22.67 12.41 53 193006 10132 110386108
Enterocolitis infectious 22.65 12.41 29 193030 3415 110392825
Refeeding syndrome 22.55 12.41 10 193049 220 110396020
Chemotherapy 22.49 12.41 23 193036 2123 110394117
Oesophageal cancer metastatic 22.44 12.41 11 193048 306 110395934
End stage renal disease 22.42 12.41 5 193054 21468 110374772
Band sensation 22.30 12.41 17 193042 1061 110395179
Hyperlipidaemia 22.16 12.41 18 193041 35830 110360410
Taste disorder 22.07 12.41 51 193008 65336 110330904
Failure to anastomose 22.07 12.41 10 193049 232 110396008
Delusion 22.02 12.41 7 193052 23748 110372492
Myopathy 22.02 12.41 8 193051 24952 110371288
Nail toxicity 22.01 12.41 12 193047 418 110395822
Haematoma 21.92 12.41 43 193016 58433 110337807
Acute interstitial pneumonitis 21.88 12.41 19 193040 1427 110394813
Gastrointestinal inflammation 21.88 12.41 50 193009 9419 110386821
Peripheral motor neuropathy 21.68 12.41 31 193028 4055 110392185
Chronic kidney disease 21.57 12.41 65 192994 76226 110320014
Respiratory failure 21.54 12.41 510 192549 214822 110181418
Duodenal stenosis 21.53 12.41 16 193043 961 110395279
Hernia 21.48 12.41 4 193055 19496 110376744
Radiation interaction 21.46 12.41 7 193052 63 110396177
Terminal ileitis 21.29 12.41 20 193039 1664 110394576
Ischiorectal hernia 21.29 12.41 5 193054 10 110396230
Rhinitis allergic 21.26 12.41 3 193056 17919 110378321
Anaemia of malignant disease 21.25 12.41 16 193043 980 110395260
Vaginal discharge 21.23 12.41 3 193056 17905 110378335
Eye disorder 21.23 12.41 12 193047 28894 110367346
Fear 21.21 12.41 7 193052 23186 110373054
Tracheo-oesophageal fistula 21.20 12.41 14 193045 695 110395545
Tumour invasion 21.18 12.41 13 193046 568 110395672
Gastrointestinal stoma output increased 21.14 12.41 16 193043 988 110395252
Intervertebral disc protrusion 21.07 12.41 11 193048 27687 110368553
Oral dysaesthesia 21.02 12.41 10 193049 260 110395980
Blood pressure diastolic decreased 20.98 12.41 19 193040 35866 110360374
Eczema impetiginous 20.94 12.41 6 193053 33 110396207
Pulmonary fistula 20.91 12.41 8 193051 119 110396121
Palmar erythema 20.85 12.41 23 193036 2315 110393925
Pigmentation disorder 20.79 12.41 42 193017 7269 110388971
Pneumomediastinum 20.78 12.41 34 193025 5002 110391238
Hepatic encephalopathy 20.72 12.41 101 192958 28155 110368085
Retroperitoneal abscess 20.67 12.41 13 193046 593 110395647
Microgenia 20.66 12.41 5 193054 12 110396228
Tinnitus 20.61 12.41 47 193012 60493 110335747
Blood glucose decreased 20.59 12.41 13 193046 29475 110366765
Device issue 20.54 12.41 18 193041 34517 110361723
Peritoneal neoplasm 20.49 12.41 8 193051 126 110396114
Tympanic membrane disorder 20.47 12.41 9 193050 194 110396046
Colonic fistula 20.42 12.41 14 193045 740 110395500
Brugada syndrome 20.34 12.41 19 193040 1569 110394671
Epstein-Barr virus infection 20.31 12.41 4 193055 18734 110377506
Deafness neurosensory 20.27 12.41 49 193010 9570 110386670
Interventricular septum rupture 20.23 12.41 6 193053 38 110396202
Hepatotoxicity 20.22 12.41 184 192875 63216 110333024
Lichenoid keratosis 20.11 12.41 38 193021 6264 110389976
Clostridial infection 20.11 12.41 38 193021 6264 110389976
Prothrombin level decreased 20.07 12.41 20 193039 1790 110394450
Perirectal abscess 19.96 12.41 22 193037 2212 110394028
Bile duct stenosis 19.95 12.41 24 193035 2652 110393588
Streptococcal bacteraemia 19.92 12.41 32 193027 4637 110391603
Malaise 19.92 12.41 964 192095 670855 109725385
Off label use 19.91 12.41 2946 190113 1497239 108899001
Influenza like illness 19.87 12.41 83 192976 88329 110307911
Chemotherapy toxicity attenuation 19.86 12.41 5 193054 15 110396225
Mucosal disorder 19.84 12.41 31 193028 4386 110391854
Nervousness 19.83 12.41 21 193038 36830 110359410
Tumour fistulisation 19.83 12.41 8 193051 138 110396102
Crying 19.76 12.41 10 193049 25618 110370622
Hallucination, visual 19.75 12.41 24 193035 39581 110356659
Pain in jaw 19.73 12.41 37 193022 51140 110345100
Type I hypersensitivity 19.72 12.41 38 193021 6355 110389885
Perforation bile duct 19.58 12.41 7 193052 85 110396155
Overflow diarrhoea 19.50 12.41 9 193050 218 110396022
Arteritis 19.48 12.41 16 193043 1113 110395127
Scintillating scotoma 19.43 12.41 9 193050 220 110396020
Osteonecrosis of jaw 19.41 12.41 147 192912 47870 110348370
Chimerism 19.38 12.41 10 193049 311 110395929
Bronchospasm 19.32 12.41 104 192955 30135 110366105
Tongue pigmentation 19.24 12.41 6 193053 46 110396194
Gastroenteritis aeromonas 19.24 12.41 6 193053 46 110396194
Periportal sinus dilatation 19.17 12.41 8 193051 151 110396089
Soft tissue disorder 19.09 12.41 27 193032 3497 110392743
Hepatic fibrosis 19.09 12.41 43 193016 8023 110388217
Cyst 19.01 12.41 3 193056 16493 110379747
Mucocutaneous rash 19.01 12.41 7 193052 93 110396147
Stomal hernia 19.01 12.41 12 193047 551 110395689
Mood swings 18.99 12.41 8 193051 22804 110373436
Blood triglycerides increased 18.96 12.41 9 193050 23917 110372323
Chemotherapy cardiotoxicity attenuation 18.95 12.41 5 193054 19 110396221
Needle issue 18.94 12.41 4 193055 17836 110378404
Liver disorder 18.91 12.41 158 192901 142085 110254155
Proteus infection 18.89 12.41 24 193035 2804 110393436
Colitis ischaemic 18.86 12.41 71 192988 17679 110378561
Aphthous ulcer 18.81 12.41 80 192979 21056 110375184
Malignant pleural effusion 18.77 12.41 29 193030 4064 110392176
Anal fistula 18.76 12.41 44 193015 8429 110387811
Suture rupture 18.74 12.41 13 193046 700 110395540
Head discomfort 18.71 12.41 5 193054 18995 110377245
Stoma site pain 18.71 12.41 20 193039 1943 110394297
Carpal tunnel syndrome 18.71 12.41 8 193051 22602 110373638
Hepatic cytolysis 18.70 12.41 162 192897 54891 110341349
Corneal toxicity 18.68 12.41 7 193052 98 110396142
Colorectal cancer recurrent 18.68 12.41 7 193052 98 110396142
Ulcer haemorrhage 18.65 12.41 8 193051 22563 110373677
Neonatal asphyxia 18.64 12.41 4 193055 4 110396236
Intrahepatic portal hepatic venous fistula 18.64 12.41 4 193055 4 110396236
Rash maculo-papular 18.64 12.41 205 192854 74017 110322223
Anorectal discomfort 18.60 12.41 29 193030 4097 110392143
Haemorrhage intracranial 18.60 12.41 14 193045 28955 110367285
Thrombocytopenia neonatal 18.56 12.41 5 193054 21 110396219
Glycosylated haemoglobin increased 18.54 12.41 9 193050 23610 110372630
Pseudomembranous colitis 18.52 12.41 37 193022 6354 110389886
Oesophageal candidiasis 18.43 12.41 53 193006 11481 110384759
Rectosigmoid cancer 18.40 12.41 10 193049 346 110395894
Perihepatic abscess 18.34 12.41 8 193051 169 110396071
Bone density decreased 18.31 12.41 3 193056 16039 110380201
Subdural haematoma 18.28 12.41 22 193037 36432 110359808
Coronary artery disease 18.24 12.41 64 192995 71626 110324614
Nodule 18.23 12.41 18 193041 32613 110363627
Immune-mediated lung disease 18.20 12.41 33 193026 5270 110390970
Dyslipidaemia 18.19 12.41 3 193056 15962 110380278
Oesophageal squamous cell carcinoma metastatic 18.17 12.41 4 193055 5 110396235
Hiatus hernia 18.16 12.41 13 193046 27593 110368647
Colitis microscopic 18.08 12.41 58 193001 13336 110382904
Mydriasis 18.08 12.41 8 193051 22149 110374091
Acute pulmonary oedema 18.07 12.41 68 192991 16928 110379312
Weight fluctuation 18.06 12.41 8 193051 22137 110374103
Endometrial dysplasia 18.01 12.41 5 193054 24 110396216
Gastric disorder 17.96 12.41 19 193040 33338 110362902
Acne 17.95 12.41 110 192949 33410 110362830
Blepharitis 17.80 12.41 30 193029 4522 110391718
Blood bilirubin increased 17.79 12.41 207 192852 75765 110320475
Product substitution issue 17.78 12.41 9 193050 23052 110373188
Hepatitis B surface antigen positive 17.76 12.41 8 193051 183 110396057
Hyperchylomicronaemia 17.74 12.41 6 193053 61 110396179
Vocal cord paralysis 17.74 12.41 24 193035 2982 110393258
Gastric varices haemorrhage 17.73 12.41 11 193048 490 110395750
Intestinal strangulation 17.66 12.41 6 193053 62 110396178
Muscle rigidity 17.62 12.41 10 193049 24021 110372219
Eye swelling 17.59 12.41 19 193040 33029 110363211
Rectal cancer 17.59 12.41 27 193032 3762 110392478
Wernicke's encephalopathy 17.53 12.41 5 193054 27 110396213
Respiratory tract infection 17.52 12.41 65 192994 71552 110324688
Phlebitis 17.48 12.41 47 193012 9794 110386446
Minimal residual disease 17.48 12.41 14 193045 939 110395301
Radiation hepatitis 17.38 12.41 4 193055 7 110396233
Middle insomnia 17.37 12.41 7 193052 20495 110375745
Anhedonia 17.35 12.41 3 193056 15425 110380815
Limbic encephalitis 17.28 12.41 13 193046 795 110395445
Pancreatic fistula 17.23 12.41 7 193052 123 110396117
Gastrointestinal stenosis 17.22 12.41 10 193049 394 110395846
Basal cell carcinoma 17.22 12.41 33 193026 45237 110351003
Dystonia 17.18 12.41 12 193047 25793 110370447
Eye infection gonococcal 17.09 12.41 5 193054 30 110396210
Glaucoma 17.04 12.41 9 193050 22508 110373732
Spinal stenosis 16.99 12.41 6 193053 19050 110377190
Flushing 16.95 12.41 267 192792 104469 110291771
Visceral venous thrombosis 16.95 12.41 5 193054 31 110396209
Vascular pain 16.92 12.41 15 193044 1158 110395082
Splenic abscess 16.89 12.41 14 193045 986 110395254
Peripheral ischaemia 16.89 12.41 50 193009 11008 110385232
Monocytopenia 16.89 12.41 8 193051 206 110396034
Pneumatosis 16.88 12.41 14 193045 987 110395253
Necrotising colitis 16.85 12.41 18 193041 1747 110394493
Pneumonitis chemical 16.82 12.41 12 193047 676 110395564
Tooth disorder 16.81 12.41 16 193043 29493 110366747
Viral hepatitis carrier 16.81 12.41 5 193054 32 110396208
Hypertrichosis 16.74 12.41 18 193041 1760 110394480
Hypertriglyceridaemia 16.66 12.41 64 192995 16090 110380150
Soft tissue necrosis 16.65 12.41 15 193044 1183 110395057
Blood pressure diastolic increased 16.64 12.41 6 193053 18801 110377439
Subdiaphragmatic abscess 16.59 12.41 7 193052 136 110396104
Urinary tract infection 16.58 12.41 438 192621 325844 110070396
Labelled drug-drug interaction medication error 16.56 12.41 16 193043 29286 110366954
Gallbladder disorder 16.52 12.41 8 193051 21021 110375219
Periodontal disease 16.51 12.41 19 193040 2003 110394237
Transient aphasia 16.50 12.41 12 193047 697 110395543
Full blood count decreased 16.49 12.41 19 193040 32080 110364160
Transposition of the great vessels 16.49 12.41 6 193053 77 110396163
Rectal stenosis 16.45 12.41 10 193049 429 110395811
Dysstasia 16.44 12.41 20 193039 32966 110363274
Ankle fracture 16.42 12.41 7 193052 19812 110376428
Affect lability 16.39 12.41 6 193053 18631 110377609
Respiratory depression 16.38 12.41 19 193040 31982 110364258
Catabolic state 16.35 12.41 6 193053 79 110396161
Gastric varices 16.31 12.41 13 193046 866 110395374
Skin laceration 16.26 12.41 21 193038 33732 110362508
Tendonitis 16.24 12.41 13 193046 26070 110370170
Artery dissection 16.21 12.41 10 193049 441 110395799
Haemorrhagic infarction 16.18 12.41 13 193046 876 110395364
Retroperitoneal lymphadenopathy 16.16 12.41 16 193043 1420 110394820
Eyelash changes 16.14 12.41 4 193055 11 110396229
Phrenic nerve paralysis 16.13 12.41 11 193048 576 110395664
Gallbladder rupture 16.10 12.41 15 193044 1235 110395005
Injection site urticaria 16.09 12.41 5 193054 17210 110379030
Catheter site bruise 16.07 12.41 11 193048 580 110395660
Cholecystocholangitis 16.06 12.41 3 193056 0 110396240
Infected neoplasm 16.00 12.41 11 193048 584 110395656
Hydrothorax 15.99 12.41 17 193042 1641 110394599
Metastases to bladder 15.99 12.41 9 193050 334 110395906
Diabetes mellitus inadequate control 15.98 12.41 17 193042 29758 110366482
Upper-airway cough syndrome 15.95 12.41 4 193055 15853 110380387
Metapneumovirus bronchiolitis 15.89 12.41 4 193055 12 110396228
Gait apraxia 15.85 12.41 5 193054 40 110396200
Renal tubular disorder 15.82 12.41 38 193021 7391 110388849
Hypocapnia 15.77 12.41 13 193046 909 110395331
Toxicity to various agents 15.75 12.41 682 192377 479873 109916367
Endothelial dysfunction 15.75 12.41 9 193050 344 110395896
Hypersplenism 15.67 12.41 12 193047 754 110395486
Haemorrhagic tumour necrosis 15.63 12.41 5 193054 42 110396198
Prerenal failure 15.63 12.41 28 193031 4431 110391809
Thrombophlebitis migrans 15.56 12.41 12 193047 762 110395478
Skin lesion 15.54 12.41 148 192911 51483 110344757
Blood pressure abnormal 15.50 12.41 10 193049 22414 110373826
Trismus 15.43 12.41 35 193024 6561 110389679
Myocardial infarction 15.42 12.41 239 192820 191844 110204396
Onychoclasis 15.39 12.41 37 193022 7200 110389040
Hyperglycaemia 15.36 12.41 221 192838 84869 110311371
Implant site dehiscence 15.27 12.41 7 193052 167 110396073
Hyperleukocytosis 15.26 12.41 24 193035 3415 110392825
Tooth infection 15.23 12.41 10 193049 22206 110374034
Malignant gastrointestinal obstruction 15.23 12.41 5 193054 46 110396194
Pachymeningitis 15.20 12.41 10 193049 493 110395747
Oesophagectomy 15.20 12.41 4 193055 15 110396225
Vaginal fistula 15.18 12.41 9 193050 369 110395871
Jaundice cholestatic 15.16 12.41 58 193001 14550 110381690
Blood culture positive 15.08 12.41 42 193017 8934 110387306
Gastrointestinal fistula 15.04 12.41 13 193046 970 110395270
Anal injury 15.00 12.41 7 193052 174 110396066
Acquired tracheo-oesophageal fistula 14.97 12.41 7 193052 175 110396065
Dementia 14.96 12.41 20 193039 31653 110364587
Inferior vena caval occlusion 14.95 12.41 6 193053 102 110396138
Scab 14.95 12.41 54 193005 13182 110383058
Obstruction gastric 14.93 12.41 18 193041 1993 110394247
Intestinal transit time abnormal 14.90 12.41 6 193053 103 110396137
Carbohydrate antigen 15-3 increased 14.83 12.41 16 193043 1571 110394669
Blood lactate dehydrogenase increased 14.82 12.41 130 192929 44204 110352036
Normal newborn 14.82 12.41 10 193049 21886 110374354
Duodenal varices 14.81 12.41 4 193055 17 110396223
Cancer fatigue 14.79 12.41 9 193050 387 110395853
Dandy-Walker syndrome 14.68 12.41 5 193054 52 110396188
Marchiafava-Bignami disease 14.62 12.41 4 193055 18 110396222
Dermatomyositis 14.60 12.41 27 193032 4379 110391861
Mediastinitis 14.59 12.41 15 193044 1393 110394847
Hepatitis B reactivation 14.58 12.41 37 193022 7447 110388793
Hypertensive encephalopathy 14.58 12.41 14 193045 1197 110395043
Aortic intramural haematoma 14.54 12.41 7 193052 187 110396053
Respiratory distress 14.54 12.41 184 192875 68690 110327550
Mouth ulceration 14.49 12.41 138 192921 48000 110348240
Neuropathic muscular atrophy 14.43 12.41 5 193054 55 110396185
Febrile infection 14.41 12.41 27 193032 4421 110391819
Pancreatic carcinoma metastatic 14.41 12.41 26 193033 4138 110392102
Prostatic calcification 14.29 12.41 6 193053 115 110396125
Haematemesis 14.27 12.41 162 192897 58946 110337294
Inferior vena cava stenosis 14.24 12.41 6 193053 116 110396124
Keratoacanthoma 14.24 12.41 15 193044 1433 110394807
Cold sweat 14.23 12.41 76 192983 21955 110374285
Micturition urgency 14.22 12.41 8 193051 19312 110376928
Abdominal sepsis 14.20 12.41 19 193040 2336 110393904
Enterocolitis haemorrhagic 14.18 12.41 20 193039 2584 110393656
Anaphylactic shock 14.17 12.41 145 192914 51401 110344839
ECG signs of myocardial ischaemia 14.15 12.41 9 193050 419 110395821
Temperature difference of extremities 14.12 12.41 4 193055 21 110396219
Acute cutaneous lupus erythematosus 14.11 12.41 9 193050 421 110395819
Mucosal ulceration 14.05 12.41 19 193040 2360 110393880
Portal vein dilatation 14.04 12.41 5 193054 60 110396180
Hepatic vein stenosis 14.04 12.41 5 193054 60 110396180
Catheter site extravasation 14.04 12.41 10 193049 562 110395678
Lhermitte's sign 13.98 12.41 3 193056 3 110396237
Body temperature decreased 13.98 12.41 27 193032 36908 110359332
Glomerular filtration rate decreased 13.97 12.41 18 193041 28938 110367302
Cold dysaesthesia 13.96 12.41 4 193055 22 110396218
Tachycardia 13.91 12.41 505 192554 226140 110170100
Lymph node abscess 13.82 12.41 5 193054 63 110396177
Premature delivery 13.81 12.41 20 193039 30612 110365628
Cerebral vasoconstriction 13.79 12.41 15 193044 1486 110394754
Postoperative abscess 13.74 12.41 12 193047 908 110395332
Therapy responder 13.70 12.41 9 193050 443 110395797
Pneumothorax 13.69 12.41 107 192952 35178 110361062
Intestinal fistula 13.68 12.41 16 193043 1717 110394523
Pleural fistula 13.67 12.41 4 193055 24 110396216
Tonic clonic movements 13.66 12.41 21 193038 2931 110393309
Diverticulum 13.65 12.41 5 193054 15521 110380719
Klebsiella test positive 13.63 12.41 19 193040 2427 110393813
Scratch 13.59 12.41 3 193056 12976 110383264
Breast mass 13.59 12.41 38 193021 8103 110388137
Autoimmune haemolytic anaemia 13.58 12.41 45 193014 10522 110385718
Upper limb fracture 13.53 12.41 10 193049 20878 110375362
Axillary vein thrombosis 13.52 12.41 11 193048 755 110395485
Hepatic cancer recurrent 13.51 12.41 8 193051 327 110395913
Osteonecrosis 13.47 12.41 103 192956 33638 110362602
Metastases to eye 13.45 12.41 8 193051 330 110395910
Brachiocephalic vein thrombosis 13.36 12.41 8 193051 334 110395906
Swollen tongue 13.36 12.41 57 193002 60305 110335935
Gastrointestinal disorder 13.30 12.41 321 192738 241631 110154609
Abnormal dreams 13.29 12.41 3 193056 12777 110383463
Hypotony of eye 13.29 12.41 9 193050 466 110395774
Precursor T-lymphoblastic lymphoma/leukaemia 13.29 12.41 6 193053 138 110396102
Embolism venous 13.28 12.41 28 193031 4995 110391245
Hand-foot-genital syndrome 13.27 12.41 4 193055 27 110396213
Neurosarcoidosis 13.26 12.41 9 193050 468 110395772
Osteoradionecrosis 13.25 12.41 6 193053 139 110396101
Throat tightness 13.24 12.41 102 192957 33387 110362853
Vitamin B1 deficiency 13.19 12.41 12 193047 958 110395282
T-cell type acute leukaemia 13.19 12.41 8 193051 342 110395898
Electromyogram abnormal 13.17 12.41 6 193053 141 110396099
Rash follicular 13.17 12.41 6 193053 141 110396099
Peritoneal adhesions 13.17 12.41 8 193051 343 110395897
Poor venous access 13.16 12.41 14 193045 24508 110371732
Depressed mood 13.10 12.41 58 193001 60751 110335489
Sarcoidosis 13.10 12.41 50 193009 12529 110383711
Laryngeal dyspnoea 13.06 12.41 8 193051 348 110395892
Myasthenia gravis 13.05 12.41 11 193048 21500 110374740
Traumatic fracture 13.03 12.41 13 193046 1165 110395075
Perineal abscess 12.99 12.41 11 193048 798 110395442
Supraventricular tachycardia 12.99 12.41 80 192979 24342 110371898
Malignant anorectal neoplasm 12.97 12.41 5 193054 76 110396164
Faecaloma 12.94 12.41 56 193003 14852 110381388
Paraesthesia mucosal 12.90 12.41 4 193055 30 110396210
Bacterial colitis 12.89 12.41 7 193052 242 110395998
Prostatic specific antigen increased 12.89 12.41 3 193056 12508 110383732
Cardiac failure acute 12.88 12.41 79 192980 23999 110372241
Throat irritation 12.84 12.41 49 193010 53503 110342737
Metastases to rectum 12.79 12.41 4 193055 31 110396209
Cholelithiasis 12.77 12.41 62 192997 63360 110332880
Oesophageal ulcer perforation 12.77 12.41 3 193056 6 110396234
UGT1A1 gene polymorphism 12.77 12.41 3 193056 6 110396234
Cholecystitis acute 12.73 12.41 58 193001 15724 110380516
Procedural vomiting 12.68 12.41 12 193047 1008 110395232
Immune-mediated hypothyroidism 12.67 12.41 20 193039 2855 110393385
Tissue injury 12.65 12.41 6 193053 155 110396085
Hyperamylasaemia 12.64 12.41 13 193046 1208 110395032
Pustular psoriasis 12.63 12.41 4 193055 13601 110382639
Anal fissure 12.63 12.41 42 193017 9839 110386401
Diffuse large B-cell lymphoma 12.57 12.41 6 193053 15892 110380348
Hepatic mass 12.55 12.41 20 193039 2878 110393362
Blood test abnormal 12.52 12.41 19 193040 28535 110367705
COVID-19 pneumonia 12.51 12.41 29 193030 37114 110359126
Ecthyma 12.49 12.41 12 193047 1027 110395213
Hepatitis B DNA increased 12.46 12.41 11 193048 844 110395396
Vascular access site swelling 12.46 12.41 3 193056 7 110396233
Malnutrition 12.46 12.41 86 192973 27193 110369047
Vitamin D decreased 12.44 12.41 3 193056 12212 110384028
Peritoneal haematoma 12.41 12.41 7 193052 261 110395979

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Craniosynostosis 49.25 44.39 9 19 59 113866

Pharmacologic Action:

SourceCodeDescription
ATC L01BC02 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Pyrimidine analogues
ATC L01BC52 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
ANTIMETABOLITES
Pyrimidine analogues
FDA MoA N0000000233 Nucleic Acid Synthesis Inhibitors
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
FDA EPC N0000175595 Nucleoside Metabolic Inhibitor
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:39456 antiglaucoma drug
CHEBI has role CHEBI:50249 anticoagulant
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:132992 radiosensitizing agent

Related Drugs by ATC class:

L01BC Pyrimidine analogues 9 drugs
azacitidinecapecitabinecarmofurcytarabinedecitabinefloxuridinegemcitabinetegafurtrifluridine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Actinic keratosis indication 201101007 DOID:8866
Metastasis from malignant tumor of colon indication 314998002
Malignant tumor of stomach indication 363349007 DOID:10534
Malignant tumor of colon indication 363406005 DOID:219
Small intestine cancer indication 363509000 DOID:10154
Superficial basal cell carcinoma indication 403914000
Adenocarcinoma of pancreas indication 700423003 DOID:4074
Metastatic Breast Carcinoma indication
Carcinoid syndrome off-label use 35868009
Actinic cheilitis off-label use 46795000
Radiation dermatitis off-label use 49084001
Neoplasm of glans penis off-label use 126898002
Carcinoma of breast off-label use 254838004 DOID:3459
Malignant tumor of head and/or neck off-label use 255056009
Malignant tumor of cervix off-label use 363354003 DOID:4362
Malignant tumor of esophagus off-label use 363402007
Malignant tumor of anus off-label use 363490009 DOID:14110
Malignant tumor of urinary bladder off-label use 399326009 DOID:11054
Leukoplakia of oral mucosa off-label use 414603003
Pancreatic Neuroendocrine Tumor off-label use 717919005
Biliary Tract Malignancy off-label use
Metastatic Malignant Tumor of Anus off-label use
Nutritional disorder contraindication 2492009 DOID:374
Acute vomiting contraindication 23971007
Stomatitis contraindication 61170000 DOID:9637
Diarrhea contraindication 62315008
Acute infectious disease contraindication 63171007
Gastrointestinal hemorrhage contraindication 74474003
Dihydrouracil dehydrogenase (NADP^+^) deficiency contraindication 77365006 DOID:14218
Leukopenia contraindication 84828003 DOID:615
Kidney disease contraindication 90708001 DOID:557
Superficial ulcer of skin contraindication 93448009
Secondary malignant neoplasm of bone marrow contraindication 94217008
Bleeding contraindication 131148009
Angina pectoris contraindication 194828000
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Pharyngitis contraindication 405737000 DOID:2275
Breastfeeding (mother) contraindication 413712001
Palmar-Plantar Erythrodysesthesia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.02 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thymidylate synthase Enzyme INHIBITOR WOMBAT-PK CHEMBL
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
ATP-binding cassette sub-family C member 11 Transporter WOMBAT-PK
Aromatase Enzyme IC50 6.20 CHEMBL
Thymidylate synthase Enzyme IC50 7.70 CHEMBL
Uracil phosphoribosyltransferase Enzyme Ki 4.89 CHEMBL

External reference:

IDSource
4017806 VUID
N0000146166 NUI
D00584 KEGG_DRUG
202632 RXNORM
C0016360 UMLSCUI
CHEBI:46345 CHEBI
URF PDB_CHEM_ID
CHEMBL185 ChEMBL_ID
D005472 MESH_DESCRIPTOR_UI
DB00544 DRUGBANK_ID
1421 INN_ID
U3P01618RT UNII
3385 PUBCHEM_CID
4745 MMSL
6969 MMSL
d00235 MMSL
4789 IUPHAR_LIGAND_ID
4694 MMSL
4017806 VANDF
002646 NDDF
3127006 SNOMEDCT_US
387172005 SNOMEDCT_US
U3P01618RT INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Efudex HUMAN PRESCRIPTION DRUG LABEL 1 0187-3202 SOLUTION 0.50 g TOPICAL NDA 2 sections
Efudex HUMAN PRESCRIPTION DRUG LABEL 1 0187-3203 SOLUTION 1.25 g TOPICAL NDA 2 sections
Efudex HUMAN PRESCRIPTION DRUG LABEL 1 0187-3204 CREAM 2 g TOPICAL NDA 2 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 0378-4791 CREAM 5 mg TOPICAL NDA authorized generic 19 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 16714-178 CREAM 50 mg TOPICAL ANDA 20 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 16729-276 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 26 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 16729-276 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 26 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 16729-542 CREAM 50 mg TOPICAL ANDA 19 sections
FLUOROURACIL HUMAN PRESCRIPTION DRUG LABEL 1 21695-829 CREAM 50 mg TOPICAL ANDA 18 sections
Fluorouracil Human Prescription Drug Label 1 21922-041 SOLUTION 50 mg TOPICAL ANDA 18 sections
Fluorouracil Human Prescription Drug Label 1 21922-041 SOLUTION 50 mg TOPICAL ANDA 18 sections
FLUOROURACIL HUMAN PRESCRIPTION DRUG LABEL 1 21922-049 CREAM 2 g TOPICAL ANDA 18 sections
fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 25021-215 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 30 sections
TOLAK HUMAN PRESCRIPTION DRUG LABEL 1 28105-421 CREAM 0.04 g TOPICAL NDA 26 sections
Fluorouracil Human Prescription Drug Label 1 46708-751 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 24 sections
Fluorouracil Human Prescription Drug Label 1 46708-779 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 24 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 50090-4264 CREAM 50 mg TOPICAL ANDA 20 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 51672-4062 SOLUTION 20 mg TOPICAL ANDA 20 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 51672-4063 SOLUTION 50 mg TOPICAL ANDA 20 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 51672-4118 CREAM 50 mg TOPICAL ANDA 20 sections
FLUOROURACIL HUMAN PRESCRIPTION DRUG LABEL 1 51862-362 CREAM 50 mg TOPICAL ANDA 20 sections
FLUOROURACIL Human Prescription Drug Label 1 54868-6293 CREAM 50 mg TOPICAL ANDA 18 sections
FLUOROURACIL Human Prescription Drug Label 1 55150-496 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 27 sections
FLUOROURACIL Human Prescription Drug Label 1 55150-497 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 27 sections
FLUOROURACIL Human Prescription Drug Label 1 55150-498 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 26 sections
FLUOROURACIL Human Prescription Drug Label 1 55150-499 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 26 sections
Fluorouracil Human Prescription Drug Label 1 62332-751 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 25 sections
Fluorouracil Human Prescription Drug Label 1 62332-779 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 25 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 63323-117 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 25 sections
Fluorouracil HUMAN PRESCRIPTION DRUG LABEL 1 63323-117 INJECTION, SOLUTION 50 mg INTRAVENOUS ANDA 25 sections