tiotropium bromide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
atropine derivatives 2677 186691-13-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tiotropium bromide hydrate
  • tiotropium
  • respimat
  • tiotropium bromide
  • tiotropium bromide monohydrate
  • spiriva
  • tiotropiumbromide
A scopolamine derivative and CHOLINERGIC ANTAGONIST that functions as a BRONCHODILATOR AGENT. It is used in the treatment of CHRONIC OBSTRUCTIVE PULMONARY DISEASE.
  • Molecular weight: 392.51
  • Formula: C19H22NO4S2
  • CLOGP: -1.91
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 59.06
  • ALOGS: -4.44
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mcg Inhal.powder
5 mcg Inhal.solution

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 74 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.00 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 2.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 32 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 12.60 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.28 % Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -0.203 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.862 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.585 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 2.992 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 78.830 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 61.370 % High 1
herg hERG pIC50 4.526 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.545 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.388 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 57.880 % High 1
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,NTRK2,PDK1,PDK4,PRKDC,TEK 17
kinase-selectivity-class AXL,EIF2AK3,GRK2,MAP2K6 4
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 3.936 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 1.600 High 1
mh-clint Mouse hepatocyte intrinsic clearance 17.022 High 1
mppb Mouse plasma protein binding (% unbound) 60.660 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 2.600 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 72.180 % High 1
rat-kpuu-brain Rat brain Kpuu 0.012 % High 1
rh-clint Rat hepatocyte intrinsic clearance 14.355 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 90.440 % High 1
rppb Rat plasma protein binding (% unbound) 51.550 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 897.429 uM High 1

Approvals:

DateAgencyCompanyOrphan
Jan. 30, 2004 FDA BOEHRINGER INGELHEIM

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Incorrect route of product administration 6011.88 11.29 2461 144323 48165 90433498
Asthma 3388.64 11.29 2936 143848 239224 90242439
Dyspnoea 2372.98 11.29 4705 142079 876250 89605413
Obstructive airways disorder 1861.94 11.29 886 145898 24983 90456680
Chronic obstructive pulmonary disease 1649.42 11.29 1182 145602 72647 90409016
Wheezing 1432.97 11.29 1843 144941 236237 90245426
Cough 1233.19 11.29 2169 144615 366793 90114870
Productive cough 1179.25 11.29 986 145798 76077 90405586
Full blood count abnormal 1076.57 11.29 695 146089 35902 90445761
Sputum discoloured 873.44 11.29 493 146291 19898 90461765
Forced expiratory volume decreased 843.12 11.29 327 146457 5481 90476182
Sleep disorder due to a general medical condition 662.53 11.29 562 146222 44176 90437487
Pneumonia 627.51 11.29 2359 144425 635700 89845963
Creatinine renal clearance decreased 583.12 11.29 370 146414 18529 90463134
Sedation complication 576.49 11.29 353 146431 16591 90465072
Chest discomfort 495.30 11.29 840 145944 137525 90344138
Synovitis 477.46 11.29 12 146772 329740 90151923
Orthostatic hypotension 470.32 11.29 450 146334 41377 90440286
Systemic lupus erythematosus 459.24 11.29 33 146751 361863 90119800
Contraindicated product administered 440.87 11.29 18 146766 320121 90161542
Blood calcium decreased 440.35 11.29 376 146408 29806 90451857
Hand deformity 420.83 11.29 13 146771 296349 90185314
Sedation 392.68 11.29 436 146348 47735 90433928
Middle insomnia 389.27 11.29 275 146509 16476 90465187
Product quality issue 386.19 11.29 555 146229 78770 90402893
Dyspnoea exertional 384.95 11.29 528 146256 71760 90409903
Pericarditis 383.01 11.29 12 146772 270139 90211524
Treatment failure 376.26 11.29 31 146753 303897 90177766
Therapeutic product effect incomplete 375.57 11.29 912 145872 192984 90288679
Arthropathy 361.93 11.29 76 146708 366166 90115497
Loss of personal independence in daily activities 360.65 11.29 726 146058 135379 90346284
Balance disorder 357.40 11.29 597 146187 96483 90385180
Glossodynia 350.06 11.29 52 146732 321727 90159936
Drug intolerance 346.12 11.29 146 146638 447445 90034218
Off label use 342.39 11.29 805 145979 1101447 89380216
Anti-cyclic citrullinated peptide antibody positive 333.36 11.29 11 146773 236422 90245241
Cognitive disorder 326.74 11.29 478 146306 68929 90412734
Blood immunoglobulin E increased 319.51 11.29 152 146632 4273 90477390
Bronchiectasis 319.24 11.29 275 146509 22055 90459608
Folliculitis 314.23 11.29 3 146781 204350 90277313
Maternal exposure during pregnancy 311.19 11.29 98 146686 359965 90121698
Lung neoplasm malignant 305.29 11.29 278 146506 23995 90457668
Total lung capacity increased 301.27 11.29 152 146632 4869 90476794
Infusion related reaction 298.85 11.29 151 146633 416629 90065034
Nasal congestion 297.76 11.29 506 146278 82908 90398755
Pulmonary mass 294.35 11.29 294 146490 28478 90453185
Alopecia 292.04 11.29 225 146559 494846 89986817
Nasal polyps 291.49 11.29 195 146589 10685 90470978
Helicobacter infection 289.61 11.29 20 146764 226830 90254833
Wound 285.00 11.29 70 146714 302910 90178753
Depressed level of consciousness 283.23 11.29 459 146325 72325 90409338
Asthma-chronic obstructive pulmonary disease overlap syndrome 272.73 11.29 141 146643 4758 90476905
Reversible airways obstruction 267.89 11.29 106 146678 1877 90479786
Abdominal discomfort 262.84 11.29 232 146552 477096 90004567
Joint swelling 259.11 11.29 260 146524 503040 89978623
Psoriatic arthropathy 257.46 11.29 33 146751 228302 90253361
Eosinophil count increased 248.08 11.29 190 146594 12891 90468772
Impaired healing 247.49 11.29 41 146743 234158 90247505
Dysphonia 247.03 11.29 399 146385 62685 90418978
Bronchitis 247.03 11.29 672 146112 152255 90329408
Irritable bowel syndrome 246.36 11.29 25 146759 207423 90274240
Hepatic enzyme increased 235.06 11.29 147 146637 360589 90121074
Rales 234.57 11.29 199 146585 15628 90466035
Respiratory tract infection 226.35 11.29 370 146414 58708 90422955
Upper-airway cough syndrome 223.69 11.29 190 146594 14945 90466718
Secretion discharge 223.64 11.29 194 146590 15702 90465961
Rheumatoid arthritis 218.57 11.29 161 146623 362453 90119210
Exposure during pregnancy 218.55 11.29 58 146726 238352 90243311
Liver injury 209.33 11.29 18 146766 170549 90311114
Completed suicide 203.52 11.29 7 146777 145051 90336612
Rhinitis allergic 198.96 11.29 186 146598 16599 90465064
Discomfort 195.59 11.29 100 146684 274235 90207428
Bronchial secretion retention 195.37 11.29 102 146682 3513 90478150
Asthmatic crisis 193.15 11.29 83 146701 1827 90479836
C-reactive protein abnormal 190.84 11.29 3 146781 127426 90354237
Blister 187.76 11.29 89 146695 254909 90226754
Vital capacity decreased 187.09 11.29 80 146704 1739 90479924
Therapeutic product effect decreased 186.51 11.29 109 146675 277462 90204201
Cardiac murmur 186.25 11.29 186 146598 18008 90463655
Swelling 181.67 11.29 248 146536 418810 90062853
Sleep disorder due to general medical condition, insomnia type 181.29 11.29 6 146778 128688 90352975
Gastrointestinal disorder 177.92 11.29 97 146687 256590 90225073
Throat clearing 175.55 11.29 97 146687 3750 90477913
Joint range of motion decreased 170.08 11.29 13 146771 135630 90346033
Blood cholesterol increased 166.86 11.29 64 146720 207948 90273715
Fall 166.48 11.29 1341 145443 480469 90001194
Sarcoidosis 166.01 11.29 138 146646 10535 90471128
Bronchopulmonary aspergillosis allergic 163.77 11.29 92 146692 3674 90477989
Forced vital capacity decreased 162.75 11.29 64 146720 1114 90480549
Intentional product use issue 159.20 11.29 76 146708 216816 90264847
Hypoventilation 159.14 11.29 102 146682 5194 90476469
Emphysema 156.34 11.29 141 146643 12014 90469649
Eosinophilia 152.70 11.29 209 146575 28324 90453339
Total lung capacity decreased 149.72 11.29 87 146697 3708 90477955
Breath sounds abnormal 149.64 11.29 153 146631 15233 90466430
Influenza 149.51 11.29 531 146253 138733 90342930
Haemoptysis 148.88 11.29 224 146560 33096 90448567
Sputum culture positive 146.38 11.29 72 146712 2181 90479482
Nasal obstruction 144.89 11.29 75 146709 2537 90479126
Lip dry 144.75 11.29 4 146780 100951 90380712
Constipation 142.56 11.29 858 145926 279537 90202126
Bronchial wall thickening 141.14 11.29 69 146715 2062 90479601
Sensitivity to weather change 133.98 11.29 113 146671 8801 90472862
Restrictive pulmonary disease 131.53 11.29 68 146716 2294 90479369
Injury 130.41 11.29 79 146705 197270 90284393
Oropharyngeal pain 128.64 11.29 445 146339 114742 90366921
Stomatitis 127.82 11.29 154 146630 274544 90207119
Eosinophilic granulomatosis with polyangiitis 127.13 11.29 68 146716 2462 90479201
Respiratory tract congestion 126.37 11.29 187 146597 27223 90454440
Peak expiratory flow rate decreased 125.59 11.29 45 146739 597 90481066
Lung opacity 125.39 11.29 93 146691 6009 90475654
Rhinitis 124.86 11.29 131 146653 13441 90468222
Respiratory rate increased 123.80 11.29 141 146643 15860 90465803
Peripheral venous disease 121.54 11.29 3 146781 83918 90397745
Product use issue 116.80 11.29 223 146561 329696 90151967
C-reactive protein increased 116.54 11.29 75 146709 181314 90300349
Sleep apnoea syndrome 116.43 11.29 195 146589 31552 90450111
Musculoskeletal stiffness 116.24 11.29 188 146596 296344 90185319
Rash 116.21 11.29 784 146000 795316 89686347
Oxygen saturation decreased 114.63 11.29 409 146375 107074 90374589
Neutropenia 114.59 11.29 117 146667 224787 90256876
Gastrooesophageal reflux disease 112.93 11.29 551 146233 165786 90315877
Heart rate increased 112.30 11.29 420 146364 112482 90369181
Pulmonary function test decreased 111.93 11.29 77 146707 4417 90477246
Impaired quality of life 109.74 11.29 160 146624 22984 90458679
Respiration abnormal 109.63 11.29 96 146688 7867 90473796
Eosinophil count abnormal 109.03 11.29 44 146740 822 90480841
Intentional overdose 104.66 11.29 14 146770 93820 90387843
Lung diffusion test abnormal 104.19 11.29 33 146751 291 90481372
Prescribed overdose 103.27 11.29 17 146767 97608 90384055
Multiple allergies 103.11 11.29 125 146659 15021 90466642
Grip strength decreased 102.81 11.29 14 146770 92562 90389101
Night sweats 100.96 11.29 41 146743 128725 90352938
Live birth 100.82 11.29 7 146777 79100 90402563
Prolonged expiration 99.46 11.29 46 146738 1211 90480452
Liver disorder 96.08 11.29 38 146746 121231 90360432
Drug-induced liver injury 94.93 11.29 16 146768 90302 90391361
Hypoaesthesia 94.14 11.29 233 146551 313977 90167686
Lung diffusion test decreased 93.64 11.29 39 146745 792 90480871
Blood pressure systolic increased 92.72 11.29 255 146529 58090 90423573
Arthralgia 92.70 11.29 811 145973 777711 89703952
Blood test abnormal 92.38 11.29 140 146644 20812 90460851
Allergy to animal 90.33 11.29 47 146737 1607 90480056
Wound infection 88.22 11.29 31 146753 106371 90375292
Bursitis 87.94 11.29 52 146732 131602 90350061
Therapy non-responder 87.15 11.29 57 146727 136647 90345016
Blood pressure increased 86.84 11.29 582 146202 196635 90285028
Hypotension 86.09 11.29 855 145929 324542 90157121
Factor V Leiden mutation 85.01 11.29 28 146756 283 90481380
Thrombocytopenia 84.93 11.29 129 146655 208596 90273067
Bronchospasm 83.79 11.29 133 146651 20576 90461087
Hypoxia 83.69 11.29 283 146501 72116 90409547
Pregnancy 83.63 11.29 4 146780 62043 90419620
Asthma exercise induced 82.75 11.29 31 146753 470 90481193
Lung hyperinflation 82.65 11.29 42 146742 1366 90480297
Hypomania 82.06 11.29 86 146698 8811 90472852
Red blood cell sedimentation rate increased 81.75 11.29 17 146767 82578 90399085
Osteoarthritis 81.55 11.29 119 146665 195611 90286052
Choking 81.41 11.29 99 146685 11934 90469729
Inflammation 80.02 11.29 103 146681 178489 90303174
Sciatica 79.93 11.29 32 146752 101350 90380313
Malaise 79.64 11.29 1362 145422 584624 89897039
Type 2 diabetes mellitus 79.47 11.29 129 146655 203115 90278548
Febrile neutropenia 78.81 11.29 84 146700 158265 90323398
Upper respiratory tract infection 78.60 11.29 413 146371 127905 90353758
Dislocation of vertebra 77.45 11.29 3 146781 55965 90425698
Hypercapnia 77.23 11.29 73 146711 6604 90475059
Dust allergy 77.22 11.29 34 146750 795 90480868
Vocal cord dysfunction 77.19 11.29 35 146749 879 90480784
Blepharospasm 76.63 11.29 3 146781 55442 90426221
Seasonal allergy 76.18 11.29 135 146649 22848 90458815
Hypercholesterolaemia 76.09 11.29 34 146750 100858 90380805
Oedema peripheral 75.79 11.29 693 146091 257222 90224441
Jaundice cholestatic 75.17 11.29 87 146697 9956 90471707
Blood calcium increased 74.84 11.29 95 146689 11963 90469700
Obesity 74.32 11.29 39 146745 105468 90376195
Diabetes mellitus 73.59 11.29 252 146532 64623 90417040
Schizophrenia 73.47 11.29 105 146679 14809 90466854
Adverse event 73.44 11.29 50 146734 117368 90364295
Infective exacerbation of chronic obstructive airways disease 72.04 11.29 39 146745 1447 90480216
Autoimmune disorder 71.55 11.29 18 146766 76726 90404937
Taste disorder 71.53 11.29 8 146776 61538 90420125
Illness 71.01 11.29 292 146492 81677 90399986
Hip arthroplasty 70.81 11.29 18 146766 76190 90405473
Fibromyalgia 70.72 11.29 142 146642 206127 90275536
Epilepsy 69.80 11.29 23 146761 82183 90399480
Prescribed underdose 69.17 11.29 18 146766 75001 90406662
White blood cell count decreased 68.24 11.29 103 146681 167006 90314657
Hyper IgE syndrome 68.24 11.29 27 146757 478 90481185
Drug hypersensitivity 67.74 11.29 456 146328 463153 90018510
Knee arthroplasty 67.66 11.29 25 146759 83157 90398506
Psoriasis 67.45 11.29 84 146700 147670 90333993
Aphonia 67.06 11.29 91 146693 12228 90469435
Broncholithiasis 65.69 11.29 23 146761 284 90481379
Creatinine renal clearance increased 65.17 11.29 49 146735 3232 90478431
Multiple drug therapy 65.09 11.29 68 146716 6941 90474722
Viral infection 64.80 11.29 180 146604 41234 90440429
Ill-defined disorder 64.48 11.29 126 146658 184765 90296898
Sinus disorder 64.40 11.29 160 146624 34287 90447376
Spirometry abnormal 64.24 11.29 22 146762 253 90481410
Lower limb fracture 63.56 11.29 29 146755 84984 90396679
Nail disorder 63.11 11.29 10 146774 59057 90422606
Respiratory gas exchange disorder 62.82 11.29 24 146760 385 90481278
Acute respiratory failure 62.73 11.29 182 146602 42736 90438927
Rhinorrhoea 62.38 11.29 296 146488 88020 90393643
Onychomadesis 61.88 11.29 3 146781 45995 90435668
Diarrhoea 61.64 11.29 1111 145673 938079 89543584
Pulmonary function test abnormal 61.40 11.29 44 146740 2695 90478968
Lupus-like syndrome 60.32 11.29 5 146779 48841 90432822
Increased upper airway secretion 60.21 11.29 50 146734 3811 90477852
Oesophageal spasm 59.77 11.29 47 146737 3314 90478349
Vision blurred 58.85 11.29 342 146442 109951 90371712
Smoke sensitivity 57.87 11.29 24 146760 482 90481181
Frustration tolerance decreased 56.76 11.29 67 146717 7829 90473834
Paraesthesia 56.76 11.29 211 146573 250115 90231548
Exposure to allergen 55.94 11.29 24 146760 526 90481137
Rubber sensitivity 55.53 11.29 42 146742 2795 90478868
Heart sounds 55.39 11.29 30 146754 1114 90480549
Confusional state 55.33 11.29 382 146402 385823 90095840
Musculoskeletal pain 55.25 11.29 122 146662 171129 90310534
Eczema 54.49 11.29 199 146585 52671 90428992
Injection site scab 54.30 11.29 25 146759 651 90481012
Weight decreased 54.06 11.29 890 145894 379020 90102643
Paroxysmal extreme pain disorder 54.00 11.29 16 146768 110 90481553
Infection 53.94 11.29 354 146430 361740 90119923
Drug ineffective for unapproved indication 52.59 11.29 21 146763 66623 90415040
Exostosis 52.45 11.29 11 146773 53123 90428540
Rib deformity 52.42 11.29 19 146765 261 90481402
Malignant neoplasm progression 51.72 11.29 58 146726 106812 90374851
Humidity intolerance 51.71 11.29 21 146763 399 90481264
Road traffic accident 51.44 11.29 59 146725 107567 90374096
Amnesia 51.30 11.29 60 146724 108445 90373218
Skin candida 51.00 11.29 33 146751 1708 90479955
Product physical issue 50.94 11.29 54 146730 5606 90476057
Bone erosion 50.28 11.29 12 146772 53009 90428654
Disease progression 50.17 11.29 112 146672 156503 90325160
Lymph node calcification 49.74 11.29 20 146764 370 90481293
Mycobacterium avium complex infection 49.70 11.29 46 146738 4052 90477611
General physical health deterioration 49.51 11.29 354 146430 354761 90126902
Bronchial obstruction 49.44 11.29 32 146752 1657 90480006
Coeliac disease 48.93 11.29 7 146777 44603 90437060
Respiratory failure 48.85 11.29 344 146440 118074 90363589
Onychomycosis 48.53 11.29 3 146781 37373 90444290
Foot deformity 48.39 11.29 18 146766 59633 90422030
Throat irritation 48.27 11.29 181 146603 48514 90433149
Degenerative bone disease 48.22 11.29 18 146766 270 90481393
Aspiration 47.97 11.29 89 146695 15604 90466059
Suicide attempt 47.29 11.29 32 146752 75367 90406296
Oesophageal pain 47.15 11.29 46 146738 4328 90477335
Dyspepsia 46.92 11.29 164 146620 197996 90283667
Renal function test abnormal 46.77 11.29 58 146726 7133 90474530
Bronchitis chronic 45.82 11.29 47 146737 4696 90476967
Sputum purulent 45.55 11.29 28 146756 1324 90480339
Perfume sensitivity 45.16 11.29 25 146759 970 90480693
Hepatic cirrhosis 45.11 11.29 23 146761 63230 90418433
Throat tightness 45.00 11.29 127 146657 29357 90452306
Respiratory depression 44.72 11.29 86 146698 15489 90466174
Status asthmaticus 44.71 11.29 24 146760 875 90480788
Pancytopenia 44.54 11.29 79 146705 120184 90361479
Respiratory distress 43.91 11.29 151 146633 38795 90442868
Chronic respiratory disease 43.87 11.29 17 146767 284 90481379
Confusional arousal 43.43 11.29 17 146767 292 90481371
Mite allergy 43.40 11.29 23 146761 817 90480846
CFTR gene mutation 43.30 11.29 16 146768 233 90481430
Lower respiratory tract congestion 43.29 11.29 39 146745 3317 90478346
Platelet count decreased 43.01 11.29 99 146685 136870 90344793
Increased bronchial secretion 42.42 11.29 32 146752 2121 90479542
Forced expiratory flow decreased 42.16 11.29 13 146771 104 90481559
Body temperature decreased 41.78 11.29 108 146676 23708 90457955
Sleep disorder 41.63 11.29 172 146612 197858 90283805
Colitis ulcerative 41.38 11.29 23 146761 60243 90421420
Muscular weakness 41.30 11.29 183 146601 206483 90275180
Idiopathic intracranial hypertension 41.13 11.29 39 146745 3542 90478121
Laryngeal stenosis 40.75 11.29 26 146758 1313 90480350
Nasal discharge discolouration 40.49 11.29 35 146749 2818 90478845
Drug tolerance decreased 40.49 11.29 3 146781 32127 90449536
Gait inability 40.46 11.29 113 146671 146343 90335320
Occupational asthma 40.42 11.29 14 146770 167 90481496
Hypersensitivity 40.34 11.29 507 146277 454170 90027493
Post procedural hypothyroidism 39.90 11.29 17 146767 366 90481297
Hypoacusis 39.64 11.29 117 146667 27733 90453930
Hepatitis 39.29 11.29 34 146750 70705 90410958
Ageusia 39.27 11.29 83 146701 15993 90465670
Condition aggravated 39.11 11.29 704 146080 594841 89886822
Pneumonia viral 38.96 11.29 59 146725 8764 90472899
Frequent bowel movements 38.70 11.29 22 146762 56913 90424750
Hepatic cytolysis 38.64 11.29 3 146781 30913 90450750
Carcinoid tumour pulmonary 37.96 11.29 18 146766 502 90481161
Muscle spasticity 37.69 11.29 6 146778 35316 90446347
Bronchomalacia 37.20 11.29 14 146770 215 90481448
Cholestasis 36.90 11.29 7 146777 36292 90445371
Finger deformity 36.46 11.29 5 146779 32892 90448771
Cardiac failure congestive 36.30 11.29 279 146505 98415 90383248
HIV infection 35.86 11.29 17 146767 474 90481189
Feeling abnormal 35.61 11.29 421 146363 166814 90314849
Oedema 35.57 11.29 185 146599 200110 90281553
Peripheral swelling 35.39 11.29 464 146320 412642 90069021
Rhonchi 35.29 11.29 33 146751 2945 90478718
Blood immunoglobulin E decreased 35.20 11.29 13 146771 189 90481474
Memory impairment 35.13 11.29 182 146602 197062 90284601
Painful respiration 34.91 11.29 33 146751 2985 90478678
Alanine aminotransferase increased 34.43 11.29 89 146695 118249 90363414
Pleuritic pain 34.09 11.29 61 146723 10400 90471263
Amniotic fluid index increased 34.05 11.29 11 146773 104 90481559
Wrist fracture 34 11.29 77 146707 15547 90466116
Abortion spontaneous 33.82 11.29 23 146761 54033 90427630
Neurosensory hypoacusis 33.72 11.29 13 146771 214 90481449
Expiratory reserve volume decreased 33.30 11.29 9 146775 42 90481621
Myocardial infarction 33.27 11.29 289 146495 105683 90375980
Pain 33.24 11.29 1299 145485 995042 89486621
Pneumothorax spontaneous 32.93 11.29 20 146764 925 90480738
Fibromuscular dysplasia 32.75 11.29 14 146770 304 90481359
Respiratory disorder 32.64 11.29 198 146586 64618 90417045
Dry throat 32.03 11.29 51 146733 7909 90473754
Glossitis 31.89 11.29 34 146750 3553 90478110
Multiple sclerosis relapse 31.74 11.29 23 146761 52282 90429381
Psychotic disorder 31.71 11.29 117 146667 31113 90450550
Back injury 31.71 11.29 18 146766 46604 90435059
Intentional product misuse 31.28 11.29 61 146723 89543 90392120
Pulmonary congestion 30.93 11.29 85 146699 19348 90462315
Bacterial disease carrier 30.85 11.29 25 146759 1841 90479822
Polyp 30.80 11.29 49 146735 7595 90474068
Polymyalgia rheumatica 30.55 11.29 39 146745 4938 90476725
Chest pain 30.52 11.29 705 146079 318940 90162723
Decreased bronchial secretion 30.36 11.29 9 146775 62 90481601
Pharyngeal oedema 30.11 11.29 68 146716 13703 90467960
Walking aid user 30.02 11.29 10 146774 35496 90446167
Skin lesion 29.93 11.29 130 146654 37235 90444428
Chest X-ray abnormal 29.91 11.29 39 146745 5043 90476620
Anaphylactic reaction 29.76 11.29 243 146541 87281 90394382
Tympanosclerosis 29.75 11.29 9 146775 67 90481596
Seizure 29.38 11.29 137 146647 152492 90329171
Cytokine release syndrome 29.29 11.29 5 146779 27968 90453695
Intentional self-injury 29.10 11.29 6 146778 29328 90452335
Forced expiratory volume abnormal 29.05 11.29 10 146774 117 90481546
Sputum culture 28.87 11.29 13 146771 321 90481342
Injection site reaction 28.55 11.29 67 146717 92013 90389650
Urinary retention 28.48 11.29 129 146655 37615 90444048
Drug reaction with eosinophilia and systemic symptoms 28.38 11.29 17 146767 42741 90438922
Rib fracture 27.66 11.29 100 146684 26335 90455328
Nocturnal dyspnoea 27.49 11.29 21 146763 1419 90480244
Total lung capacity abnormal 27.41 11.29 9 146775 90 90481573
Cytomegalovirus infection 27.32 11.29 5 146779 26597 90455066
Laboratory test abnormal 27.28 11.29 17 146767 41837 90439826
Hepatic function abnormal 27.26 11.29 21 146763 46267 90435396
Nausea 26.91 11.29 1498 145286 1108818 89372845
Coma 26.63 11.29 48 146736 72584 90409079
Peak expiratory flow rate abnormal 26.56 11.29 9 146775 100 90481563
Aspartate aminotransferase increased 26.56 11.29 82 146702 102855 90378808
Product use in unapproved indication 26.51 11.29 384 146400 335852 90145811
Breath sounds 26.24 11.29 9 146775 104 90481559
FEV1/FVC ratio decreased 26.14 11.29 10 146774 161 90481502
Oesophageal dilatation 25.97 11.29 14 146770 515 90481148
Hypoglobulinaemia 25.70 11.29 10 146774 169 90481494
Dyslipidaemia 25.64 11.29 53 146731 10054 90471609
Drug ineffective 25.64 11.29 1914 144870 1382384 89099279
Sinus polyp degeneration 25.62 11.29 8 146776 67 90481596
Respiratory syncytial virus infection 25.47 11.29 54 146730 10426 90471237
Palmar-plantar erythrodysaesthesia syndrome 25.31 11.29 7 146777 28016 90453647
Neoplasm progression 25.17 11.29 21 146763 44465 90437198
Candida infection 24.66 11.29 115 146669 33942 90447721
Atrial flutter 24.51 11.29 54 146730 10704 90470959
Abdominal pain upper 24.48 11.29 385 146399 332289 90149374
Underdose 24.34 11.29 31 146753 53986 90427677
Multiple organ dysfunction syndrome 24.31 11.29 46 146738 68290 90413373
Depressive symptom 24.28 11.29 36 146748 5249 90476414
Mouth injury 24.23 11.29 18 146766 1166 90480497
Adverse reaction 24.04 11.29 9 146775 29703 90451960
Increased viscosity of bronchial secretion 23.96 11.29 12 146772 378 90481285
Tremor 23.68 11.29 364 146420 152809 90328854
Incorrect dose administered 23.61 11.29 213 146571 78717 90402946
Functional residual capacity increased 23.44 11.29 8 146776 91 90481572
Abdominal pain 23.41 11.29 476 146308 395245 90086418
Drug resistance 23.37 11.29 10 146774 30439 90451224
Bronchial hyperreactivity 23.31 11.29 22 146762 1986 90479677
Neuropathy peripheral 22.93 11.29 129 146655 136841 90344822
Upper limb fracture 22.89 11.29 82 146702 21496 90460167
Product prescribing error 22.73 11.29 103 146681 30042 90451621
Pulmonary pain 22.30 11.29 34 146750 5080 90476583
Foetal macrosomia 22.21 11.29 10 146774 247 90481416
Crystal arthropathy 22.16 11.29 11 146773 340 90481323
Cardio-respiratory arrest 22.02 11.29 43 146741 63097 90418566
Cholelithiasis 21.92 11.29 153 146631 52353 90429310
Scratch 21.89 11.29 49 146735 9817 90471846
Device dislocation 21.63 11.29 12 146772 31470 90450193
Lipohypertrophy 21.63 11.29 14 146770 725 90480938
Bronchiolitis 21.36 11.29 27 146757 3385 90478278
Left-to-right cardiac shunt 21.32 11.29 10 146774 272 90481391
Intervertebral disc protrusion 21.31 11.29 94 146690 27102 90454561
Ulcer haemorrhage 21.25 11.29 8 146776 26313 90455350
Functional residual capacity decreased 21.23 11.29 7 146777 71 90481592
Bronchospasm paradoxical 21.19 11.29 8 146776 124 90481539
Adverse drug reaction 21.15 11.29 107 146677 116594 90365069
Pulmonary thrombosis 21.05 11.29 48 146736 9734 90471929
Swollen tongue 21.03 11.29 137 146647 45819 90435844
Nasal mucosal disorder 20.90 11.29 20 146764 1837 90479826
Anosmia 20.84 11.29 48 146736 9800 90471863
Leukopenia 20.83 11.29 88 146696 100622 90381041
Carbon dioxide increased 20.74 11.29 20 146764 1855 90479808
Neutrophil count decreased 20.65 11.29 54 146730 71478 90410185
Blood immunoglobulin G decreased 20.58 11.29 27 146757 3511 90478152
Nervousness 20.41 11.29 109 146675 33947 90447716
Joint stiffness 20.25 11.29 62 146722 77980 90403683
Female sterilisation 20.14 11.29 13 146771 670 90480993
Pulmonary arterial hypertension 20.13 11.29 90 146694 26097 90455566
Croup infectious 20.07 11.29 13 146771 674 90480989
Lip pruritus 19.94 11.29 17 146767 1343 90480320
Adrenal suppression 19.89 11.29 15 146769 994 90480669
Lymphoedema 19.79 11.29 58 146726 13695 90467968
Contusion 19.75 11.29 287 146497 250929 90230734
Drug eruption 19.68 11.29 17 146767 35390 90446273
Liver function test increased 19.56 11.29 71 146713 84784 90396879
Sputum increased 19.47 11.29 24 146760 2933 90478730
Delirium 19.31 11.29 95 146689 104264 90377399
Chronic respiratory failure 19.28 11.29 23 146761 2718 90478945
Animal scratch 19.27 11.29 19 146765 1811 90479852
Electrocardiogram QT prolonged 19.20 11.29 57 146727 72399 90409264
Bladder disorder 19.05 11.29 49 146735 10723 90470940
Acute myeloid leukaemia 18.93 11.29 5 146779 20635 90461028
Foetal malnutrition 18.88 11.29 7 146777 103 90481560
Fungal endocarditis 18.82 11.29 10 146774 357 90481306
Appetite disorder 18.76 11.29 44 146740 9089 90472574
Secondary hypogonadism 18.75 11.29 8 146776 173 90481490
Menopausal symptoms 18.70 11.29 24 146760 3054 90478609
Inappropriate schedule of product administration 18.67 11.29 344 146440 149589 90332074
Perineal fistula 18.51 11.29 7 146777 109 90481554
Occult blood 18.44 11.29 16 146768 1295 90480368
Pulmonary hypertension 18.39 11.29 125 146659 42398 90439265
Laryngectomy 18.39 11.29 5 146779 24 90481639
Dyspnoea at rest 18.33 11.29 30 146754 4761 90476902
Pustular psoriasis 17.99 11.29 4 146780 18552 90463111
Lung neoplasm 17.90 11.29 36 146748 6699 90474964
Anti-cyclic citrullinated peptide antibody 17.82 11.29 11 146773 27210 90454453
Musculoskeletal chest pain 17.79 11.29 81 146703 23669 90457994
Aspergillus test positive 17.78 11.29 10 146774 400 90481263
Pancreatitis relapsing 17.77 11.29 16 146768 1360 90480303
Decreased appetite 17.75 11.29 469 146315 376071 90105592
Pharyngeal disorder 17.73 11.29 21 146763 2462 90479201
Premature delivery 17.72 11.29 22 146762 38740 90442923
Abnormal dreams 17.68 11.29 49 146735 11208 90470455
Aspirin-exacerbated respiratory disease 17.60 11.29 12 146772 678 90480985
Musculoskeletal discomfort 17.56 11.29 74 146710 20917 90460746
Eye infection bacterial 17.48 11.29 9 146775 301 90481362
Hypopituitarism foetal 17.46 11.29 5 146779 30 90481633
Congenital hypogonadotropic hypogonadism 17.46 11.29 5 146779 30 90481633
Glaucoma 17.23 11.29 73 146711 20682 90460981
Pneumococcal infection 17.12 11.29 15 146769 1230 90480433
Septic shock 17.12 11.29 74 146710 84086 90397577
Forced expiratory volume increased 17.07 11.29 6 146778 75 90481588
Lymphocyte count decreased 16.98 11.29 19 146765 35031 90446632
Blood creatine phosphokinase increased 16.97 11.29 18 146766 34005 90447658
Transient ischaemic attack 16.97 11.29 124 146660 43052 90438611
Eye swelling 16.90 11.29 93 146691 29293 90452370
Joint dislocation 16.76 11.29 29 146755 44553 90437110
Infusion site reaction 16.74 11.29 5 146779 19034 90462629
Sense of oppression 16.64 11.29 14 146770 1086 90480577
Oxygen saturation abnormal 16.61 11.29 27 146757 4261 90477402
Device difficult to use 16.55 11.29 4 146780 17521 90464142
Status epilepticus 16.52 11.29 5 146779 18869 90462794
Airway remodelling 16.52 11.29 6 146778 83 90481580
Cytopenia 16.44 11.29 4 146780 17445 90464218
Inhalation therapy 16.44 11.29 5 146779 38 90481625
Eye allergy 16.41 11.29 15 146769 1300 90480363
Acute hepatic failure 16.39 11.29 8 146776 22553 90459110
Respiratory tract inflammation 16.34 11.29 11 146773 609 90481054
Epistaxis 16.26 11.29 210 146574 84915 90396748
Migraine 16.22 11.29 214 146570 190178 90291485
Exercise tolerance decreased 16.19 11.29 37 146747 7514 90474149
Renal artery angioplasty 16.18 11.29 4 146780 12 90481651
Swelling face 16.09 11.29 202 146582 81150 90400513
Blood bilirubin increased 16.04 11.29 123 146661 43347 90438316
Lower respiratory tract infection 16.01 11.29 525 146259 250134 90231529
Polycystic ovaries 15.96 11.29 31 146753 5623 90476040
Plasma cell myeloma 15.86 11.29 26 146758 40802 90440861
Respiratory tract irritation 15.85 11.29 10 146774 495 90481168
Metastases to liver 15.81 11.29 14 146770 28793 90452870
Cerebral infarction 15.74 11.29 12 146772 26584 90455079
Angina pectoris 15.70 11.29 113 146671 39047 90442616
Magnesium metabolism disorder 15.50 11.29 5 146779 47 90481616
Respiratory acidosis 15.48 11.29 38 146746 8081 90473582
Vomiting 15.47 11.29 1084 145700 787209 89694454
Affect lability 15.42 11.29 5 146779 18058 90463605
White coat hypertension 15.42 11.29 13 146771 1012 90480651
Proctitis 15.39 11.29 3 146781 15256 90466407
Skin laceration 15.38 11.29 83 146701 25952 90455711
Pharyngeal swelling 15.34 11.29 43 146741 9901 90471762
Blood immunoglobulin E 15.32 11.29 5 146779 49 90481614
Decreased activity 15.26 11.29 38 146746 8154 90473509
Mononeuropathy multiplex 15.25 11.29 9 146775 395 90481268
Skin ulcer 15.07 11.29 37 146747 50038 90431625
Adenocarcinoma 15.01 11.29 22 146762 3174 90478489
Coordination abnormal 14.88 11.29 8 146776 21348 90460315
Fatigue 14.83 11.29 1640 145144 1152383 89329280
Brain hypoxia 14.77 11.29 10 146774 559 90481104
Depressed mood 14.75 11.29 135 146649 50087 90431576
Dementia 14.73 11.29 77 146707 23784 90457879
Cataract 14.68 11.29 180 146604 71912 90409751
Ear discomfort 14.66 11.29 43 146741 10157 90471506
Infective aneurysm 14.58 11.29 9 146775 429 90481234
Drug withdrawal syndrome 14.55 11.29 15 146769 28708 90452955
Cardiogenic shock 14.53 11.29 11 146773 24457 90457206
Enterobiasis 14.49 11.29 6 146778 120 90481543
Mobility decreased 14.46 11.29 519 146265 250215 90231448
Allergic cough 14.34 11.29 13 146771 1115 90480548
Aphasia 14.21 11.29 30 146754 42782 90438881
Right ventricular systolic pressure 14.21 11.29 3 146781 3 90481660
Poor quality device used 14.12 11.29 18 146766 2275 90479388
Respiratory symptom 14.12 11.29 25 146759 4227 90477436
Muscle rigidity 14.04 11.29 3 146781 14306 90467357
Rash vesicular 13.92 11.29 6 146778 18191 90463472
Arthritis 13.91 11.29 189 146595 167126 90314537
Caffeine allergy 13.83 11.29 4 146780 25 90481638
Hyponatraemia 13.82 11.29 298 146486 133240 90348423
Atrial fibrillation 13.77 11.29 298 146486 133313 90348350
Neuroendocrine carcinoma 13.70 11.29 8 146776 344 90481319
Allergic sinusitis 13.67 11.29 17 146767 2096 90479567
Chronic gastrointestinal bleeding 13.64 11.29 6 146778 140 90481523
Pulmonary eosinophilia 13.64 11.29 8 146776 347 90481316
Product dose omission issue 13.60 11.29 590 146194 291097 90190566
Eye pruritus 13.57 11.29 87 146697 28940 90452723
Mucosal inflammation 13.42 11.29 48 146736 57577 90424086
Acute respiratory distress syndrome 13.41 11.29 16 146768 28670 90452993
Cockroach allergy 13.40 11.29 5 146779 75 90481588
Allergy to plants 13.35 11.29 11 146773 829 90480834
Pneumothorax 13.35 11.29 64 146720 19103 90462560
Upper airway obstruction 13.33 11.29 12 146772 1020 90480643
Rash maculo-papular 13.32 11.29 29 146755 40904 90440759
Sinus congestion 13.32 11.29 83 146701 27341 90454322
Tendonitis 13.22 11.29 69 146715 21303 90460360
Diplegia 13.14 11.29 14 146770 1461 90480202
Ascites 13.06 11.29 37 146747 47703 90433960
Bone marrow failure 13.01 11.29 20 146764 32201 90449462
Localised infection 12.97 11.29 96 146688 33466 90448197
Tongue discomfort 12.94 11.29 19 146765 2746 90478917
Oral discharge 12.90 11.29 6 146778 160 90481503
Eosinophilic pneumonia 12.90 11.29 19 146765 2754 90478909
Steroid diabetes 12.89 11.29 18 146766 2484 90479179
Caesarean section 12.88 11.29 7 146777 18570 90463093
Congenital pharyngeal anomaly 12.86 11.29 4 146780 33 90481630
Peritonitis 12.85 11.29 8 146776 19697 90461966
Visual impairment 12.70 11.29 145 146639 132220 90349443
Pyrexia 12.66 11.29 910 145874 659575 89822088
Pulmonary oedema 12.64 11.29 155 146629 61925 90419738
Blood lactate dehydrogenase increased 12.62 11.29 14 146770 25918 90455745
Urticaria 12.60 11.29 398 146386 312336 90169327
Complication associated with device 12.54 11.29 8 146776 19441 90462222
Heavy menstrual bleeding 12.49 11.29 9 146775 20521 90461142
Shock 12.47 11.29 17 146767 28761 90452902
Leukaemia 12.46 11.29 26 146758 4966 90476697
Drug level increased 12.43 11.29 16 146768 27746 90453917
Cor pulmonale 12.42 11.29 16 146768 2044 90479619
Full blood count decreased 12.40 11.29 18 146766 29671 90451992
Ankylosing spondylitis 12.40 11.29 3 146781 13130 90468533
Oral candidiasis 12.35 11.29 99 146685 35356 90446307
Hyperventilation 12.31 11.29 31 146753 6697 90474966
Oesophagogastroduodenoscopy 12.28 11.29 6 146778 179 90481484
Immunodeficiency 12.20 11.29 33 146751 43201 90438462
Hypomagnesaemia 12.20 11.29 99 146685 35489 90446174
Laryngeal pain 12.19 11.29 24 146760 4398 90477265
Pancreatic calcification 12.18 11.29 4 146780 40 90481623
Monocytopenia 12.08 11.29 5 146779 100 90481563
Vaginal haemorrhage 12.07 11.29 20 146764 31251 90450412
Bundle branch block left 12.07 11.29 34 146750 7851 90473812
Rheumatoid nodule 12.06 11.29 9 146775 20157 90461506
Abnormal loss of weight 12.03 11.29 31 146753 6792 90474871
Hyposmia 11.99 11.29 11 146773 958 90480705
Snoring 11.98 11.29 26 146758 5100 90476563
Gastric cyst 11.98 11.29 5 146779 102 90481561
Pruritus 11.90 11.29 737 146047 540788 89940875
Tooth disorder 11.89 11.29 20 146764 31070 90450593
International normalised ratio increased 11.84 11.29 123 146661 47193 90434470
Disturbance in attention 11.82 11.29 38 146746 47071 90434592
Regurgitation 11.79 11.29 16 146768 2150 90479513
Lung carcinoma cell type unspecified recurrent 11.73 11.29 6 146778 198 90481465
Infective pulmonary exacerbation of cystic fibrosis 11.71 11.29 40 146744 10239 90471424
Parotitis 11.68 11.29 15 146769 1910 90479753
Stress 11.66 11.29 191 146593 81204 90400459
Metastases to central nervous system 11.61 11.29 7 146777 17535 90464128
Hemianopia heteronymous 11.60 11.29 4 146780 47 90481616
Spinal cord compression 11.59 11.29 25 146759 4886 90476777
Nasal septum deviation 11.57 11.29 15 146769 1928 90479735
Pancreatitis 11.56 11.29 66 146718 69760 90411903
Overweight 11.55 11.29 28 146756 5906 90475757
Trifascicular block 11.51 11.29 5 146779 113 90481550
Deep vein thrombosis 11.48 11.29 94 146690 91526 90390137
Red blood cell agglutination 11.47 11.29 3 146781 12 90481651
Aortic stenosis 11.39 11.29 29 146755 6307 90475356
Lung infiltration 11.36 11.29 52 146732 15230 90466433
Social problem 11.31 11.29 12 146772 1247 90480416

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 3119.87 12.00 1915 101121 60399 42457900
Incorrect route of product administration 2494.20 12.00 1203 101833 23102 42495197
Wheezing 2182.80 12.00 1459 101577 53322 42464977
Dyspnoea 1763.95 12.00 3514 99522 439107 42079192
Obstructive airways disorder 1439.02 12.00 839 102197 23920 42494379
Full blood count abnormal 1249.60 12.00 821 102215 29055 42489244
Chronic obstructive pulmonary disease 1196.29 12.00 1083 101953 62031 42456268
Productive cough 971.17 12.00 882 102154 50685 42467614
Therapeutic product effect incomplete 939.82 12.00 1001 102035 69938 42448361
Sleep disorder due to a general medical condition 796.79 12.00 507 102529 16946 42501353
Cough 708.67 12.00 1419 101617 176684 42341615
Loss of personal independence in daily activities 659.38 12.00 703 102333 49113 42469186
Forced expiratory volume decreased 449.31 12.00 261 102775 7369 42510930
Sputum discoloured 417.27 12.00 276 102760 9856 42508443
Chest discomfort 381.17 12.00 607 102429 63009 42455290
Off label use 380.73 12.00 600 102436 637735 41880564
Dyspnoea exertional 375.37 12.00 531 102505 49617 42468682
Bronchiectasis 356.09 12.00 317 102719 17702 42500597
Breath sounds abnormal 305.31 12.00 245 102791 11848 42506451
Product quality issue 269.93 12.00 271 102765 17611 42500688
Asthma-chronic obstructive pulmonary disease overlap syndrome 254.85 12.00 107 102929 1452 42516847
Dust allergy 248.46 12.00 157 102879 5175 42513124
Pneumonia 243.80 12.00 1798 101238 420351 42097948
Toxicity to various agents 243.74 12.00 125 102911 229011 42289288
Emphysema 231.41 12.00 207 102829 11628 42506671
Spirometry abnormal 226.08 12.00 146 102890 5000 42513299
Pulmonary function test decreased 214.11 12.00 147 102889 5585 42512714
Eosinophilic granulomatosis with polyangiitis 213.79 12.00 173 102863 8465 42509834
Nasal congestion 209.80 12.00 305 102731 29196 42489103
Pulmonary function test abnormal 199.06 12.00 107 102929 2587 42515712
Conjunctivitis allergic 193.86 12.00 140 102896 5771 42512528
Mycotic allergy 193.56 12.00 130 102906 4761 42513538
Mite allergy 189.87 12.00 130 102906 4916 42513383
Middle insomnia 183.61 12.00 152 102884 7681 42510618
Haemoptysis 181.79 12.00 367 102669 45800 42472499
Lung disorder 173.48 12.00 368 102668 47555 42470744
Benign prostatic hyperplasia 167.97 12.00 230 102806 20822 42497477
Lower respiratory tract infection 165.14 12.00 330 102706 40876 42477423
Febrile neutropenia 164.62 12.00 125 102911 185578 42332721
Drug abuse 163.86 12.00 28 103008 104743 42413556
Bronchial wall thickening 162.86 12.00 75 102961 1285 42517014
Eosinophil count increased 158.54 12.00 161 102875 10602 42507697
Normochromic normocytic anaemia 149.55 12.00 144 102892 8887 42509412
Respiratory symptom 147.20 12.00 157 102879 10949 42507350
Pulmonary vasculitis 141.49 12.00 119 102917 6147 42512152
Gastrooesophageal reflux disease 140.69 12.00 326 102710 44697 42473602
Respiratory disorder 136.62 12.00 214 102822 21871 42496428
Bronchial obstruction 134.30 12.00 71 102965 1658 42516641
Bronchial secretion retention 133.42 12.00 69 102967 1538 42516761
Neutropenia 133.31 12.00 172 102864 199259 42319040
Neuritis 132.02 12.00 114 102922 6106 42512193
Blood immunoglobulin E increased 128.43 12.00 90 102946 3535 42514764
Total lung capacity abnormal 127.24 12.00 97 102939 4346 42513953
Completed suicide 126.44 12.00 38 102998 96427 42421872
Diarrhoea 124.38 12.00 633 102403 460216 42058083
Lung hyperinflation 121.92 12.00 58 102978 1073 42517226
Nasal polyps 119.01 12.00 88 102948 3763 42514536
Hypoxia 116.90 12.00 403 102633 69383 42448916
Congenital hiatus hernia 114.81 12.00 105 102931 6069 42512230
Obstruction 112.17 12.00 78 102958 3025 42515274
Disease progression 109.95 12.00 111 102925 143545 42374754
Nasal obstruction 109.94 12.00 52 102984 949 42517350
Bronchial hyperreactivity 105.70 12.00 63 102973 1866 42516433
Eosinophil count abnormal 105.57 12.00 38 102998 330 42517969
Right atrial hypertrophy 105.34 12.00 46 102990 691 42517608
Malignant melanoma in situ 103.43 12.00 71 102965 2696 42515603
Product use in unapproved indication 97.61 12.00 186 102850 184270 42334029
Respiratory rate increased 94.55 12.00 125 102911 10937 42507362
Pulmonary mass 94.26 12.00 153 102883 16112 42502187
Allergy to animal 94.11 12.00 39 102997 511 42517788
Vasculitis 93.27 12.00 163 102873 18231 42500068
Neurological symptom 91.79 12.00 117 102919 9874 42508425
Thrombocytopenia 90.44 12.00 204 102832 190075 42328224
Nodule 88.22 12.00 129 102907 12405 42505894
Bronchitis 86.48 12.00 281 102755 46920 42471379
Sinus pain 86.20 12.00 43 102993 886 42517413
Chronic sinusitis 84.06 12.00 68 102968 3324 42514975
Upper-airway cough syndrome 82.64 12.00 75 102961 4291 42514008
Right ventricular hypertrophy 80.67 12.00 49 102987 1503 42516796
Vital capacity decreased 79.57 12.00 34 103002 483 42517816
Urinary retention 77.96 12.00 252 102784 41962 42476337
Pulmonary fibrosis 77.69 12.00 188 102848 26493 42491806
Foetal exposure during pregnancy 77.67 12.00 11 103025 47300 42470999
Arteriosclerosis coronary artery 74.10 12.00 149 102887 18528 42499771
Cytokine release syndrome 73.93 12.00 10 103026 44517 42473782
Antineutrophil cytoplasmic antibody positive 73.02 12.00 70 102966 4295 42514004
Platelet count decreased 72.18 12.00 141 102895 138440 42379859
Lung neoplasm malignant 71.53 12.00 149 102887 18998 42499301
Forced vital capacity decreased 71.32 12.00 38 102998 902 42517397
Multiple organ dysfunction syndrome 70.81 12.00 78 102958 96957 42421342
Hypercholesterolaemia 70.59 12.00 118 102918 12731 42505568
White blood cell count decreased 69.84 12.00 99 102937 110297 42408002
Pancytopenia 68.32 12.00 112 102924 117631 42400668
Nausea 67.91 12.00 623 102413 396176 42122123
Intentional overdose 67.89 12.00 20 103016 51436 42466863
Pulmonary alveolar haemorrhage 67.09 12.00 125 102911 14691 42503608
Oxygen saturation decreased 67.08 12.00 322 102714 64365 42453934
Intentional product use issue 65.31 12.00 47 102989 71786 42446513
Bronchospasm 65.09 12.00 114 102922 12771 42505528
Chest X-ray abnormal 63.78 12.00 66 102970 4442 42513857
Dyspnoea at rest 61.55 12.00 63 102973 4186 42514113
Treatment failure 59.56 12.00 39 102997 62585 42455714
Vomiting 59.51 12.00 433 102603 289290 42229009
Arteriosclerosis 58.09 12.00 132 102904 17857 42500442
Aortic valve stenosis 57.22 12.00 52 102984 2980 42515319
Vocal cord dysfunction 56.92 12.00 21 103015 197 42518102
Respiratory failure 56.78 12.00 515 102521 127617 42390682
Reversible airways obstruction 56.21 12.00 28 103008 575 42517724
Drug resistance 56.13 12.00 8 103028 34240 42484059
Mycobacterium avium complex infection 55.35 12.00 51 102985 2976 42515323
Sensitivity to weather change 55 12.00 43 102993 2000 42516299
Malaise 54.87 12.00 767 102269 211389 42306910
Alanine aminotransferase increased 54.22 12.00 81 102955 88325 42429974
Throat irritation 54.12 12.00 106 102930 12930 42505369
Sepsis 53.40 12.00 274 102762 199060 42319239
Drug ineffective for unapproved indication 52.31 12.00 23 103013 46140 42472159
Cytomegalovirus infection 51.90 12.00 8 103028 32298 42486001
Intentional product misuse 51.84 12.00 44 102992 61856 42456443
Sputum purulent 51.82 12.00 28 103008 684 42517615
Eosinophilia 51.61 12.00 186 102850 32713 42485586
Eosinophil count 51.15 12.00 19 103017 182 42518117
Mucosal inflammation 50.80 12.00 28 103008 49346 42468953
Peak expiratory flow rate decreased 50.41 12.00 17 103019 119 42518180
Influenza 50.33 12.00 289 102747 61886 42456413
Joint injury 49.98 12.00 110 102926 14566 42503733
Respiratory tract congestion 49.71 12.00 76 102960 7602 42510697
Rhinorrhoea 49.24 12.00 179 102857 31615 42486684
Aspartate aminotransferase increased 48.00 12.00 70 102966 77093 42441206
Sputum increased 47.83 12.00 48 102988 3115 42515184
Seizure 47.46 12.00 142 102894 120419 42397880
Heart rate increased 47.42 12.00 254 102782 53001 42465298
Lung consolidation 47.39 12.00 69 102967 6608 42511691
Nasopharyngitis 47.04 12.00 356 102680 83640 42434659
Blood test abnormal 46.54 12.00 99 102937 12807 42505492
Diastolic dysfunction 46.46 12.00 70 102966 6913 42511386
Pyrexia 45.45 12.00 675 102361 393367 42124932
Malignant neoplasm progression 45.36 12.00 124 102912 108276 42410023
Therapy non-responder 44.59 12.00 38 102998 53321 42464978
Leukopenia 44.37 12.00 70 102966 74676 42443623
Serotonin syndrome 42.44 12.00 6 103030 25839 42492460
Decreased activity 42.31 12.00 57 102979 5078 42513221
Blood pressure systolic increased 42.08 12.00 156 102880 27812 42490487
Forced expiratory flow decreased 41.94 12.00 16 103020 166 42518133
Suffocation feeling 41.66 12.00 24 103012 666 42517633
Asthmatic crisis 41.41 12.00 22 103014 519 42517780
Stomatitis 40.66 12.00 37 102999 50292 42468007
Rhinitis perennial 40.24 12.00 16 103020 187 42518112
Neuropathy peripheral 40.05 12.00 120 102916 101733 42416566
Sleep apnoea syndrome 39.89 12.00 129 102907 21479 42496820
Restrictive pulmonary disease 39.56 12.00 30 103006 1333 42516966
Somnolence 39.46 12.00 191 102845 140914 42377385
Septic shock 39.00 12.00 104 102932 91568 42426731
Infusion related reaction 38.96 12.00 54 102982 60752 42457547
Drug-induced liver injury 38.95 12.00 22 103014 38251 42480048
Fractured coccyx 38.87 12.00 15 103021 161 42518138
Psoriatic arthropathy 38.29 12.00 7 103029 24960 42493339
Dry mouth 38.11 12.00 194 102842 39685 42478614
Seasonal allergy 37.78 12.00 69 102967 7986 42510313
Anaemia 37.73 12.00 465 102571 279813 42238486
Rash 37.46 12.00 459 102577 276495 42241804
Transient ischaemic attack 37.19 12.00 171 102865 33568 42484731
Impaired quality of life 37.17 12.00 96 102940 14081 42504218
Pancreatitis 37.16 12.00 30 103006 43238 42475061
Suicide attempt 37.11 12.00 34 103002 46066 42472233
Therapy partial responder 37.07 12.00 3 103033 20018 42498281
Hypothyroidism 36.40 12.00 164 102872 31920 42486379
Drug hypersensitivity 36.34 12.00 121 102915 99268 42419031
Bronchopulmonary aspergillosis allergic 36.31 12.00 50 102986 4548 42513751
Brain natriuretic peptide abnormal 36.03 12.00 18 103018 372 42517927
Adverse drug reaction 36.01 12.00 23 103013 37411 42480888
Dysphonia 35.77 12.00 150 102886 28300 42489999
Sinusitis 35.17 12.00 215 102821 47077 42471222
Body temperature decreased 35.15 12.00 95 102941 14318 42503981
Dyspnoea paroxysmal nocturnal 35.00 12.00 30 103006 1590 42516709
Dysarthria 34.94 12.00 27 103009 39780 42478519
Micturition urgency 34.80 12.00 84 102952 11814 42506485
Hypoventilation 34.10 12.00 44 102992 3758 42514541
Obesity 33.83 12.00 102 102934 16357 42501942
Rhinitis allergic 33.74 12.00 44 102992 3798 42514501
Adjustment disorder 33.46 12.00 27 103009 1315 42516984
Prolonged expiration 33.39 12.00 16 103020 301 42517998
COVID-19 32.96 12.00 156 102880 115792 42402507
Hepatic function abnormal 32.83 12.00 46 102990 51521 42466778
Drug reaction with eosinophilia and systemic symptoms 32.73 12.00 32 103004 42043 42476256
Pickwickian syndrome 32.67 12.00 12 103024 111 42518188
Capillaritis 32.21 12.00 33 103003 2195 42516104
Lung diffusion test decreased 31.55 12.00 22 103014 857 42517442
Renal impairment 31.51 12.00 148 102888 110080 42408219
Bone marrow failure 30.93 12.00 21 103015 33072 42485227
Oxygen saturation increased 30.88 12.00 15 103021 291 42518008
Mycobacterial infection 30.65 12.00 35 103001 2633 42515666
Confusional state 30.37 12.00 259 102777 167338 42350961
Cardiogenic shock 30.24 12.00 25 103011 35615 42482684
Proteinuria 30.19 12.00 9 103027 22974 42495325
Overdose 29.70 12.00 142 102894 105122 42413177
Aptyalism 29.50 12.00 16 103020 394 42517905
Intervertebral disc degeneration 29.49 12.00 59 102977 7308 42510991
Respiratory tract infection 29.45 12.00 134 102902 26188 42492111
Osteoporosis 29.35 12.00 91 102945 14815 42503484
Granulomatous rosacea 29.25 12.00 12 103024 153 42518146
Ascites 29.19 12.00 58 102978 56620 42461679
Atrial fibrillation 28.84 12.00 486 102550 139107 42379192
Orthopnoea 28.76 12.00 49 102987 5368 42512931
Factitious disorder 28.75 12.00 9 103027 48 42518251
Pain 28.65 12.00 418 102618 244430 42273869
Nocturnal dyspnoea 28.57 12.00 18 103018 590 42517709
Throat clearing 28.32 12.00 18 103018 599 42517700
N-terminal prohormone brain natriuretic peptide abnormal 27.95 12.00 13 103023 228 42518071
Upper respiratory tract infection 27.82 12.00 186 102850 41987 42476312
Drug ineffective 27.75 12.00 1244 101792 628953 41889346
Product use issue 27.67 12.00 94 102942 76657 42441642
Sedation 27.61 12.00 20 103016 30455 42487844
Acute kidney injury 27.55 12.00 677 102359 366660 42151639
Prostatic adenoma 27.49 12.00 12 103024 180 42518119
Lymphopenia 27.33 12.00 9 103027 21554 42496745
C-reactive protein increased 27.11 12.00 72 102964 63488 42454811
Neutrophil count decreased 26.92 12.00 72 102964 63343 42454956
Cholestasis 26.76 12.00 24 103012 32855 42485444
Snoring 26.67 12.00 40 102996 3933 42514366
Pleural thickening 26.63 12.00 16 103020 481 42517818
Sputum abnormal 26.61 12.00 17 103019 571 42517728
Hepatocellular injury 26.50 12.00 12 103024 23666 42494633
Aphonia 26.47 12.00 41 102995 4148 42514151
Encephalopathy 26.18 12.00 37 102999 41296 42477003
Hepatic enzyme increased 26.12 12.00 44 102992 45740 42472559
Cardiac failure congestive 26.05 12.00 319 102717 85283 42433016
Osteopenia 26.00 12.00 51 102985 6227 42512072
Tubulointerstitial nephritis 25.71 12.00 23 103013 31525 42486774
Electrocardiogram QT prolonged 25.61 12.00 48 102988 47897 42470402
FEV1/FVC ratio abnormal 25.06 12.00 8 103028 46 42518253
Anxiety 24.93 12.00 414 102622 118146 42400153
Pulmonary congestion 24.72 12.00 89 102947 15641 42502658
Synovitis 24.67 12.00 4 103032 15563 42502736
No adverse event 24.65 12.00 35 103001 38986 42479313
Myoclonic epilepsy 24.57 12.00 25 103011 1649 42516650
Acute respiratory distress syndrome 24.48 12.00 22 103014 30086 42488213
Decreased gait velocity 24.34 12.00 11 103025 180 42518119
Drug interaction 24.33 12.00 477 102559 266522 42251777
Increased viscosity of bronchial secretion 24.20 12.00 12 103024 244 42518055
Multiple sclerosis relapse 24.16 12.00 3 103033 14261 42504038
Sputum retention 24.16 12.00 17 103019 672 42517627
Lacrimal disorder 23.93 12.00 13 103023 321 42517978
FEV1/FVC ratio decreased 23.93 12.00 10 103026 134 42518165
Rales 23.76 12.00 71 102965 11329 42506970
Pulmonary arterial pressure abnormal 23.72 12.00 13 103023 327 42517972
Convulsive threshold lowered 23.58 12.00 15 103021 500 42517799
Atelectasis 23.50 12.00 101 102935 19260 42499039
Hypochromic anaemia 23.33 12.00 20 103016 1060 42517239
Nasal oedema 23.26 12.00 13 103023 340 42517959
Hepatic haematoma 23.09 12.00 14 103022 428 42517871
Bronchiolitis 22.98 12.00 37 102999 3869 42514430
Psychotic disorder 22.97 12.00 22 103014 29186 42489113
Eye disorder 22.96 12.00 71 102965 11541 42506758
Multiple allergies 22.87 12.00 36 103000 3692 42514607
Poisoning 22.80 12.00 4 103032 14695 42503604
Fatigue 22.74 12.00 843 102193 434798 42083501
Vascular shunt 22.74 12.00 7 103029 35 42518264
Hyperglycaemia 22.70 12.00 48 102988 45811 42472488
Neoplasm progression 22.62 12.00 22 103014 28978 42489321
Coma 22.58 12.00 61 102975 53493 42464806
Nasal disorder 22.48 12.00 26 103010 1983 42516316
Lung opacity 22.47 12.00 46 102990 5791 42512508
Tumour lysis syndrome 22.30 12.00 13 103023 22218 42496081
Bradycardia 22.01 12.00 119 102917 85365 42432934
Eye swelling 21.85 12.00 71 102965 11849 42506450
Hereditary haemorrhagic telangiectasia 21.81 12.00 7 103029 41 42518258
Cardiac failure 21.68 12.00 371 102665 106485 42411814
Blood thyroid stimulating hormone abnormal 21.57 12.00 13 103023 393 42517906
Eosinophilic bronchitis 21.28 12.00 11 103025 245 42518054
Deep vein thrombosis 21.01 12.00 105 102931 76852 42441447
Cytopenia 20.98 12.00 8 103028 17489 42500810
Diaphragmatic disorder 20.97 12.00 20 103016 1219 42517080
Hepatotoxicity 20.93 12.00 18 103018 25149 42493150
Use of accessory respiratory muscles 20.86 12.00 14 103022 512 42517787
Appendicitis 20.75 12.00 12 103024 20601 42497698
Type 2 diabetes mellitus 20.64 12.00 94 102942 18377 42499922
Infective exacerbation of chronic obstructive airways disease 20.58 12.00 25 103011 2008 42516291
Flour sensitivity 20.37 12.00 6 103030 25 42518274
Joint swelling 20.22 12.00 90 102946 67932 42450367
Lower respiratory tract congestion 20.11 12.00 22 103014 1578 42516721
Ischaemic cardiomyopathy 20.11 12.00 47 102989 6475 42511824
Choking 20.09 12.00 46 102990 6252 42512047
Oropharyngeal discomfort 20.04 12.00 36 103000 4113 42514186
Left ventricular dilatation 20.03 12.00 17 103019 889 42517410
Electrocardiogram QRS complex abnormal 19.95 12.00 13 103023 452 42517847
Hyperkaliuria 19.93 12.00 8 103028 96 42518203
Coagulation factor V level abnormal 19.77 12.00 9 103027 150 42518149
Liver function test increased 19.63 12.00 12 103024 19986 42498313
Blood bilirubin increased 19.46 12.00 46 102990 42206 42476093
Eosinophilic pneumonia chronic 19.40 12.00 11 103025 296 42518003
Haemoglobin decreased 19.24 12.00 216 102820 132255 42386044
Factor V Leiden mutation 19.13 12.00 10 103026 228 42518071
Choking sensation 19.08 12.00 19 103017 1221 42517078
Bronchitis chronic 19.04 12.00 21 103015 1520 42516779
Dyskinesia 18.96 12.00 20 103016 25370 42492929
Tachyarrhythmia 18.84 12.00 34 103002 3898 42514401
Cough decreased 18.76 12.00 5 103031 13 42518286
Expiratory reserve volume decreased 18.76 12.00 8 103028 113 42518186
Pneumothorax 18.76 12.00 109 102927 23434 42494865
Renal failure 18.71 12.00 240 102796 143486 42374813
Musculoskeletal stiffness 18.67 12.00 74 102962 57691 42460608
Abdominal pain 18.66 12.00 336 102700 190135 42328164
Acute respiratory failure 18.64 12.00 159 102877 38699 42479600
Respiratory gas exchange disorder 18.61 12.00 13 103023 508 42517791
Peritonitis 18.54 12.00 11 103025 18622 42499677
Precancerous condition 18.45 12.00 8 103028 118 42518181
Transplant rejection 18.44 12.00 5 103031 13583 42504716
Forced expiratory volume abnormal 18.44 12.00 6 103030 37 42518262
Cardio-respiratory arrest 18.40 12.00 76 102960 58560 42459739
Decreased appetite 18.20 12.00 343 102693 192794 42325505
Blood phosphorus increased 18.19 12.00 4 103032 12521 42505778
Drug intolerance 18.03 12.00 117 102919 80307 42437992
Lactic acidosis 18.01 12.00 53 102983 45208 42473091
Atheroembolism 17.98 12.00 11 103025 342 42517957
Aplastic anaemia 17.89 12.00 4 103032 12380 42505919
Discomfort 17.71 12.00 113 102923 25106 42493193
Blood alkaline phosphatase increased 17.62 12.00 34 103002 33563 42484736
Umbilical hernia 17.62 12.00 40 102996 5407 42512892
Pneumocystis jirovecii pneumonia 17.53 12.00 21 103015 25160 42493139
Rib fracture 17.53 12.00 83 102953 16488 42501811
Transaminases increased 17.49 12.00 33 103003 32852 42485447
Haemophilus infection 17.44 12.00 20 103016 1511 42516788
Rheumatoid arthritis 17.40 12.00 49 102987 42391 42475908
Oropharyngeal pain 17.36 12.00 168 102868 42342 42475957
Hypoalbuminaemia 17.33 12.00 8 103028 15602 42502697
Blood creatinine increased 17.33 12.00 176 102860 109827 42408472
Delusion 17.23 12.00 7 103029 14727 42503572
Acute hepatic failure 17.10 12.00 10 103026 17063 42501236
Weight decreased 17.09 12.00 639 102397 207309 42310990
Panic reaction 17.07 12.00 21 103015 1709 42516590
Respiratory tract haemorrhage 17.07 12.00 19 103017 1390 42516909
Hernia pain 17.06 12.00 10 103026 287 42518012
Drug level increased 17.05 12.00 23 103013 26177 42492122
Nephrolithiasis 17.04 12.00 40 102996 36790 42481509
Posterior reversible encephalopathy syndrome 16.88 12.00 5 103031 12816 42505483
Basal cell carcinoma 16.87 12.00 18 103018 22715 42495584
Hangover 16.71 12.00 17 103019 1121 42517178
Suicidal ideation 16.67 12.00 60 102976 48101 42470198
Sneezing 16.59 12.00 43 102993 6320 42511979
Intentional self-injury 16.56 12.00 8 103028 15194 42503105
Hypoacusis 16.50 12.00 89 102947 18613 42499686
Agitation 16.30 12.00 90 102946 64224 42454075
Abscess 16.29 12.00 7 103029 14241 42504058
Hypothermia 16.26 12.00 5 103031 12510 42505789
Asbestosis 16.26 12.00 9 103027 231 42518068
Laboratory test abnormal 16.17 12.00 19 103017 22959 42495340
Functional residual capacity increased 16.08 12.00 4 103032 7 42518292
Pseudomonas bronchitis 16.08 12.00 5 103031 26 42518273
Colitis ulcerative 16.02 12.00 24 103012 26151 42492148
Myositis 15.92 12.00 8 103028 14858 42503441
Hallucination, auditory 15.92 12.00 8 103028 14856 42503443
Toxic epidermal necrolysis 15.92 12.00 25 103011 26725 42491574
Altered state of consciousness 15.89 12.00 29 103007 29230 42489069
Blood lactate dehydrogenase increased 15.88 12.00 24 103012 26057 42492242
Bone deformity 15.84 12.00 6 103030 61 42518238
Primary hypogonadism 15.80 12.00 7 103029 109 42518190
Hepatitis 15.79 12.00 26 103010 27274 42491025
Respiration abnormal 15.74 12.00 32 103004 4010 42514289
Diastolic hypertension 15.66 12.00 6 103030 63 42518236
Mesothelioma 15.65 12.00 11 103025 434 42517865
Blood pressure increased 15.59 12.00 339 102697 101589 42416710
Blood creatine phosphokinase increased 15.57 12.00 62 102974 48276 42470023
Laryngitis 15.55 12.00 25 103011 2610 42515689
Sleep disorder 15.40 12.00 181 102855 47914 42470385
Hypotension 15.38 12.00 490 102546 257141 42261158
Febrile bone marrow aplasia 15.30 12.00 3 103033 10178 42508121
Drug eruption 15.28 12.00 20 103016 23055 42495244
Diabetic ketoacidosis 15.21 12.00 19 103017 22348 42495951
Carbon dioxide increased 15.14 12.00 17 103019 1255 42517044
Large cell lung cancer metastatic 15.12 12.00 4 103032 10 42518289
Mastication disorder 15.07 12.00 20 103016 1756 42516543
Coagulation factor deficiency 15.05 12.00 9 103027 268 42518031
Sinus congestion 15.05 12.00 44 102992 6936 42511363
Pneumothorax spontaneous 14.98 12.00 14 103022 832 42517467
Right ventricular failure 14.96 12.00 54 102982 9501 42508798
Kidney infection 14.91 12.00 43 102993 6727 42511572
Bronchospasm paradoxical 14.88 12.00 6 103030 73 42518226
Blood glucose increased 14.66 12.00 111 102925 73588 42444711
Nervous system disorder 14.66 12.00 12 103024 17183 42501116
Sarcopenia 14.53 12.00 14 103022 864 42517435
Blood uric acid increased 14.35 12.00 10 103026 15537 42502762
Renal tubular necrosis 14.23 12.00 14 103022 18340 42499959
Pulmonary function test increased 14.13 12.00 4 103032 14 42518285
Renal injury 14.10 12.00 6 103030 12274 42506025
Blood albumin decreased 14.09 12.00 10 103026 15392 42502907
Haemolysis 14.05 12.00 3 103033 9586 42508713
Chest pain 14.04 12.00 439 102597 139091 42379208
Vocal cord polyp 13.99 12.00 6 103030 86 42518213
Inflammation 13.93 12.00 39 102997 33808 42484491
Congenital megaureter 13.91 12.00 7 103029 147 42518152
Back pain 13.90 12.00 250 102786 141526 42376773
Klebsiella infection 13.89 12.00 5 103031 11327 42506972
Paraneoplastic rash 13.87 12.00 6 103030 88 42518211
Small airways disease 13.83 12.00 5 103031 44 42518255
Xanthelasma 13.81 12.00 6 103030 89 42518210
Diffuse large B-cell lymphoma 13.77 12.00 3 103033 9451 42508848
Status asthmaticus 13.71 12.00 9 103027 317 42517982
Drug use disorder 13.66 12.00 4 103032 10329 42507970
Bladder discomfort 13.58 12.00 7 103029 155 42518144
Agranulocytosis 13.57 12.00 34 103002 30578 42487721
Secretion discharge 13.57 12.00 45 102991 7590 42510709
Laparoscopic surgery 13.52 12.00 4 103032 17 42518282
Blood immunoglobulin E abnormal 13.52 12.00 4 103032 17 42518282
Cystitis 13.42 12.00 60 102976 11638 42506661
Squamous cell carcinoma of skin 13.40 12.00 7 103029 12719 42505580
Hydronephrosis 13.30 12.00 6 103030 11859 42506440
Erectile dysfunction 13.25 12.00 25 103011 24888 42493411
Brain oedema 13.19 12.00 12 103024 16315 42501984
Metastases to liver 13.18 12.00 12 103024 16314 42501985
Lung diffusion disorder 13.10 12.00 7 103029 167 42518132
Upper respiratory tract congestion 13.10 12.00 14 103022 978 42517321
Disseminated intravascular coagulation 13.08 12.00 25 103011 24769 42493530
Hypophosphataemia 13.02 12.00 19 103017 20926 42497373
Abdominal symptom 13.01 12.00 11 103025 572 42517727
Intercostal neuralgia 13.01 12.00 3 103033 3 42518296
Idiopathic pulmonary fibrosis 12.93 12.00 32 103004 4572 42513727
Respiratory depression 12.86 12.00 16 103020 18852 42499447
Exercise tolerance decreased 12.85 12.00 38 102998 6028 42512271
Hepatic failure 12.83 12.00 48 102988 38052 42480247
Total lung capacity 12.83 12.00 4 103032 21 42518278
Frequent bowel movements 12.74 12.00 20 103016 21387 42496912
Humidity intolerance 12.68 12.00 4 103032 22 42518277
Skin wrinkling 12.66 12.00 10 103026 472 42517827
Dizziness exertional 12.65 12.00 8 103028 264 42518035
Oxygen therapy 12.63 12.00 16 103020 1342 42516957
Rhabdomyolysis 12.62 12.00 124 102912 77895 42440404
Hyperbilirubinaemia 12.55 12.00 19 103017 20616 42497683
Illness 12.48 12.00 103 102933 24827 42493472
Shock 12.40 12.00 33 103003 29088 42489211
Aortic aneurysm 12.39 12.00 44 102992 7679 42510620
Abdominal wall haematoma 12.32 12.00 21 103015 2301 42515998
Hepatic encephalopathy 12.22 12.00 13 103023 16429 42501870
Hyperhidrosis 12.20 12.00 150 102886 90362 42427937
Nasal discomfort 12.19 12.00 17 103019 1565 42516734
Extrapyramidal disorder 12.17 12.00 13 103023 16399 42501900
Increased bronchial secretion 12.16 12.00 21 103015 2325 42515974
Increased upper airway secretion 12.12 12.00 22 103014 2534 42515765
Immune thrombocytopenia 12.07 12.00 6 103030 11210 42507089
Apnoeic attack 12.05 12.00 10 103026 507 42517792
Gastrointestinal angiectasia 12.03 12.00 8 103028 288 42518011
Gout 12.01 12.00 112 102924 27943 42490356

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Asthma 4896.65 11.15 3932 205085 246359 110133923
Dyspnoea 3153.81 11.15 6625 202392 1100247 109280035
Obstructive airways disorder 2930.64 11.15 1525 207492 44624 110335658
Wheezing 2624.76 11.15 2803 206214 252427 110127855
Chronic obstructive pulmonary disease 2231.44 11.15 1763 207254 107395 110272887
Full blood count abnormal 2149.59 11.15 1332 207685 54720 110325562
Productive cough 2032.43 11.15 1702 207315 112603 110267679
Incorrect route of product administration 1736.30 11.15 1226 207791 62835 110317447
Cough 1677.65 11.15 3071 205946 458570 109921712
Forced expiratory volume decreased 1202.61 11.15 558 208459 12618 110367664
Sputum discoloured 1188.74 11.15 710 208307 27235 110353047
Sleep disorder due to a general medical condition 1030.34 11.15 826 208191 51286 110328996
Therapeutic product effect incomplete 745.84 11.15 1437 207580 222368 110157914
Dyspnoea exertional 741.04 11.15 948 208069 103112 110277170
Chest discomfort 720.15 11.15 1227 207790 172621 110207661
Loss of personal independence in daily activities 714.84 11.15 1128 207889 148892 110231390
Pneumonia 701.60 11.15 3391 205626 873323 109506959
Bronchiectasis 649.00 11.15 544 208473 35949 110344333
Off label use 608.30 11.15 1202 207815 1498983 108881299
Middle insomnia 531.16 11.15 382 208635 20120 110360162
Creatinine renal clearance decreased 523.34 11.15 388 208629 21427 110358855
Sedation complication 498.56 11.15 363 208654 19492 110360790
Nasal congestion 476.27 11.15 745 208272 97537 110282745
Synovitis 469.19 11.15 10 209007 274082 110106200
Breath sounds abnormal 452.31 11.15 379 208638 25025 110355257
Asthma-chronic obstructive pulmonary disease overlap syndrome 449.73 11.15 226 208791 6118 110374164
Blood immunoglobulin E increased 378.93 11.15 213 208804 7269 110373013
Product quality issue 374.54 11.15 586 208431 76713 110303569
Hand deformity 369.94 11.15 9 209008 218497 110161785
Eosinophil count increased 366.31 11.15 310 208707 20748 110359534
Systemic lupus erythematosus 359.79 11.15 33 208984 254305 110125977
Nasal polyps 351.23 11.15 250 208767 12950 110367332
Blood calcium decreased 348.43 11.15 383 208634 35462 110344820
Eosinophilic granulomatosis with polyangiitis 344.93 11.15 228 208789 10458 110369824
Haemoptysis 338.87 11.15 536 208481 70818 110309464
Treatment failure 334.47 11.15 60 208957 277174 110103108
Completed suicide 328.43 11.15 37 208980 242344 110137938
Orthostatic hypotension 319.23 11.15 501 208516 65748 110314534
Pericarditis 311.06 11.15 28 208989 219086 110161196
Dust allergy 309.79 11.15 173 208844 5828 110374454
Helicobacter infection 309.77 11.15 7 209010 181870 110198412
Emphysema 307.59 11.15 273 208744 19483 110360799
Spirometry abnormal 304.47 11.15 166 208851 5331 110374951
Bronchial secretion retention 304.28 11.15 161 208856 4863 110375419
Pulmonary mass 299.31 11.15 361 208656 36940 110343342
Infusion related reaction 294.26 11.15 178 208839 380984 109999298
Pulmonary function test decreased 291.47 11.15 190 208827 8510 110371772
Folliculitis 291.36 11.15 5 209012 167648 110212634
Arthropathy 290.30 11.15 91 208926 287431 110092851
Drug intolerance 289.29 11.15 208 208809 406304 109973978
Reversible airways obstruction 289.24 11.15 125 208892 2374 110377908
Bronchial wall thickening 286.95 11.15 134 208883 3073 110377209
Balance disorder 284.94 11.15 660 208357 115900 110264382
Total lung capacity increased 282.10 11.15 154 208863 4958 110375324
Upper-airway cough syndrome 274.91 11.15 233 208784 15624 110364658
Psoriatic arthropathy 274.36 11.15 27 208990 196734 110183548
Lung neoplasm malignant 273.96 11.15 329 208688 33513 110346769
Contraindicated product administered 268.34 11.15 69 208948 248198 110132084
Bronchitis 267.17 11.15 776 208241 156256 110224026
Mite allergy 263.88 11.15 154 208863 5649 110374633
Glossodynia 259.34 11.15 52 208965 221952 110158330
Maternal exposure during pregnancy 253.16 11.15 83 208934 254800 110125482
Alopecia 250.00 11.15 194 208823 364559 110015723
Cognitive disorder 241.35 11.15 520 208497 86991 110293291
Pulmonary function test abnormal 238.82 11.15 137 208880 4863 110375419
Irritable bowel syndrome 238.50 11.15 19 208998 164196 110216086
Sedation 237.33 11.15 452 208565 69231 110311051
Joint swelling 230.90 11.15 299 208718 442546 109937736
Rales 227.82 11.15 257 208760 24482 110355800
Wound 224.76 11.15 81 208936 234356 110145926
Impaired healing 221.73 11.15 50 208967 196667 110183615
Conjunctivitis allergic 219.15 11.15 146 208871 6785 110373497
Nasal obstruction 216.13 11.15 112 208905 3238 110377044
Intentional product use issue 215.98 11.15 99 208918 247807 110132475
Respiratory rate increased 214.84 11.15 251 208766 24832 110355450
Hepatic enzyme increased 214.43 11.15 175 208842 320717 110059565
Forced vital capacity decreased 213.24 11.15 94 208923 1876 110378406
Hypoxia 211.65 11.15 631 208386 128884 110251398
Mycotic allergy 209.23 11.15 134 208883 5820 110374462
Influenza 208.08 11.15 748 208269 168353 110211929
Respiratory tract infection 204.91 11.15 432 208585 71185 110309097
Rheumatoid arthritis 199.43 11.15 164 208853 299449 110080833
Asthmatic crisis 199.43 11.15 92 208925 2050 110378232
Vital capacity decreased 199.16 11.15 91 208926 1982 110378300
Gastrooesophageal reflux disease 197.22 11.15 767 208250 179209 110201073
Neutropenia 195.17 11.15 253 208764 374367 110005915
Febrile neutropenia 192.18 11.15 189 208828 316578 110063704
Hypoventilation 189.93 11.15 142 208875 7939 110372343
Eosinophilia 188.95 11.15 369 208648 57567 110322715
Dysphonia 187.79 11.15 432 208585 75497 110304785
Sensitivity to weather change 187.62 11.15 154 208863 9874 110370408
Therapeutic product effect decreased 183.05 11.15 118 208899 244198 110136084
C-reactive protein abnormal 182.89 11.15 17 209000 129678 110250604
Exposure during pregnancy 179.98 11.15 47 208970 167377 110212905
Throat clearing 178.78 11.15 108 208909 4225 110376057
Bronchopulmonary aspergillosis allergic 178.11 11.15 139 208878 8287 110371995
Respiratory symptom 177.97 11.15 178 208839 14767 110365515
Secretion discharge 177.43 11.15 205 208812 20039 110360243
Rhinitis allergic 176.77 11.15 193 208824 17729 110362553
Liver injury 176.12 11.15 35 208982 150378 110229904
Benign prostatic hyperplasia 175.75 11.15 194 208823 18040 110362242
Stomatitis 173.64 11.15 153 208864 270089 110110193
Abdominal discomfort 173.15 11.15 299 208718 393559 109986723
Gastrointestinal disorder 170.43 11.15 125 208892 241827 110138455
Sleep disorder due to general medical condition, insomnia type 169.30 11.15 7 209010 105636 110274646
Oxygen saturation decreased 168.72 11.15 665 208352 156317 110223965
Pulmonary vasculitis 167.09 11.15 121 208896 6439 110373843
Depressed level of consciousness 166.65 11.15 529 208488 111749 110268533
Joint range of motion decreased 166.49 11.15 18 208999 121814 110258468
Blister 166.04 11.15 113 208904 227263 110153019
Lung hyperinflation 165.65 11.15 82 208935 2147 110378135
Respiratory tract congestion 160.76 11.15 242 208775 30615 110349667
Total lung capacity abnormal 160.69 11.15 103 208914 4480 110375802
Blood cholesterol increased 160.60 11.15 74 208943 184711 110195571
Bronchial obstruction 159.58 11.15 89 208928 2990 110377292
Lip dry 159.16 11.15 7 209010 100076 110280206
Peak expiratory flow rate decreased 151.34 11.15 55 208962 645 110379637
Intentional overdose 150.66 11.15 33 208984 132468 110247814
Sleep apnoea syndrome 148.50 11.15 271 208746 40176 110340106
Blood test abnormal 147.43 11.15 223 208794 28331 110351951
Restrictive pulmonary disease 146.90 11.15 86 208931 3173 110377109
Neuritis 145.55 11.15 117 208900 7282 110373000
Multiple allergies 144.08 11.15 145 208872 12118 110368164
Normochromic normocytic anaemia 143.62 11.15 149 208868 12908 110367374
C-reactive protein increased 142.86 11.15 121 208896 217798 110162484
Eosinophil count abnormal 141.84 11.15 59 208958 1015 110379267
Heart rate increased 140.82 11.15 592 208425 143242 110237040
Congenital hiatus hernia 138.29 11.15 106 208911 6153 110374129
Thrombocytopenia 138.21 11.15 282 208735 348603 110031679
Cardiac murmur 133.82 11.15 197 208820 24431 110355851
Swelling 132.98 11.15 291 208726 350750 110029532
Allergy to animal 132.13 11.15 67 208950 1849 110378433
Sarcoidosis 132.03 11.15 140 208877 12439 110367843
Blood pressure systolic increased 131.45 11.15 400 208617 82591 110297691
Bronchospasm 131.07 11.15 218 208799 30021 110350261
Peripheral venous disease 130.18 11.15 7 209010 84110 110296172
Rash 128.20 11.15 967 208050 819997 109560285
Drug-induced liver injury 126.59 11.15 35 208982 120032 110260250
Vocal cord dysfunction 124.83 11.15 52 208965 898 110379384
Fall 122.20 11.15 1706 207311 601776 109778506
Bronchial hyperreactivity 117.74 11.15 77 208940 3467 110376815
Inflammation 117.48 11.15 115 208902 193123 110187159
Therapy non-responder 115.06 11.15 78 208939 157229 110223053
Lung diffusion test decreased 114.17 11.15 58 208959 1607 110378675
Disease progression 113.95 11.15 178 208839 243856 110136426
Diarrhoea 112.51 11.15 1499 207518 1138006 109242276
Prolonged expiration 112.10 11.15 56 208961 1496 110378786
Seasonal allergy 111.87 11.15 161 208856 19561 110360721
Product use issue 111.86 11.15 266 208751 311429 110068853
Oropharyngeal pain 111.48 11.15 529 208488 134747 110245535
Respiratory disorder 110.21 11.15 341 208676 71041 110309241
Right atrial hypertrophy 108.56 11.15 43 208974 648 110379634
Drug abuse 107.37 11.15 106 208911 177305 110202977
Bursitis 106.86 11.15 56 208961 129862 110250420
Respiration abnormal 106.21 11.15 111 208906 9698 110370584
Upper respiratory tract infection 104.20 11.15 508 208509 130820 110249462
Malignant melanoma in situ 103.36 11.15 71 208946 3471 110376811
Drug ineffective for unapproved indication 102.91 11.15 33 208984 102805 110277477
Rhinorrhoea 102.38 11.15 425 208592 102241 110278041
Total lung capacity decreased 102.26 11.15 94 208923 7020 110373262
White blood cell count decreased 101.78 11.15 173 208844 229217 110151065
Musculoskeletal stiffness 101.04 11.15 238 208779 279584 110100698
Live birth 100.98 11.15 8 209009 69476 110310806
Malaise 100.68 11.15 1806 207211 670013 109710269
Lung diffusion test abnormal 100.42 11.15 35 208982 360 110379922
Product use in unapproved indication 99.29 11.15 471 208546 446906 109933376
Drug hypersensitivity 96.77 11.15 485 208532 453605 109926677
Wound infection 96.45 11.15 31 208986 96434 110283848
Blood pressure increased 96.22 11.15 825 208192 257548 110122734
Sputum culture positive 95.12 11.15 70 208947 3819 110376463
Constipation 94.41 11.15 1063 207954 356723 110023559
Injury 94.01 11.15 118 208899 177147 110203135
Grip strength decreased 93.12 11.15 19 208998 80155 110300127
Liver disorder 91.96 11.15 80 208937 142163 110238119
Blepharospasm 90.07 11.15 3 209014 54848 110325434
Taste disorder 88.47 11.15 10 209007 65377 110314905
Right ventricular hypertrophy 87.22 11.15 49 208968 1670 110378612
Obstruction 86.59 11.15 78 208939 5674 110374608
Pancytopenia 85.90 11.15 166 208851 209447 110170835
Cytokine release syndrome 85.19 11.15 15 209002 70291 110309991
Impaired quality of life 84.60 11.15 180 208837 29837 110350445
Chest X-ray abnormal 83.01 11.15 91 208926 8396 110371886
Antineutrophil cytoplasmic antibody positive 82.72 11.15 72 208945 5004 110375278
Lung opacity 82.61 11.15 106 208911 11546 110368736
Red blood cell sedimentation rate increased 82.21 11.15 23 208994 78279 110302003
Nausea 82.14 11.15 1747 207270 1233943 109146339
Weight decreased 81.64 11.15 1290 207727 466767 109913515
Respiratory failure 80.91 11.15 689 208328 214643 110165639
Forced expiratory flow decreased 80.86 11.15 28 208989 282 110380000
Body temperature decreased 80.36 11.15 200 208817 36735 110343547
Osteoarthritis 79.84 11.15 139 208878 182484 110197798
Pregnancy 79.81 11.15 4 209013 51063 110329219
Intentional product misuse 79.73 11.15 80 208937 132824 110247458
Fibromyalgia 79.44 11.15 125 208892 170784 110209498
Arthralgia 79.18 11.15 1019 207998 778613 109601669
Lower respiratory tract infection 78.15 11.15 752 208265 242354 110137928
Neurological symptom 77.89 11.15 120 208897 15488 110364794
Confusional state 77.85 11.15 542 208475 468138 109912144
Sciatica 77.21 11.15 39 208978 92360 110287922
Platelet count decreased 76.94 11.15 204 208813 230239 110150043
Choking 76.57 11.15 117 208900 14993 110365289
Arteriosclerosis coronary artery 75.91 11.15 155 208862 24963 110355319
Illness 74.86 11.15 331 208686 81840 110298442
Discomfort 74.82 11.15 186 208831 214521 110165761
Suicide attempt 74.62 11.15 52 208965 103342 110276940
Multiple organ dysfunction syndrome 73.36 11.15 108 208909 151602 110228680
Autoimmune disorder 73.04 11.15 17 209000 65466 110314816
Infective exacerbation of chronic obstructive airways disease 72.63 11.15 55 208962 3135 110377147
Hypoaesthesia 72.53 11.15 326 208691 313897 110066385
Alanine aminotransferase increased 72.33 11.15 149 208868 183624 110196658
Rhinitis 69.17 11.15 140 208877 22405 110357877
Hypercapnia 69.08 11.15 95 208922 11064 110369218
Oedema peripheral 68.35 11.15 934 208083 327726 110052556
Hypomania 67.90 11.15 90 208927 10120 110370162
Vasculitis 67.53 11.15 184 208833 35689 110344593
Malignant neoplasm progression 67.46 11.15 143 208874 174424 110205858
Psoriasis 67.35 11.15 100 208917 139893 110240389
Prescribed overdose 67.35 11.15 41 208976 87540 110292742
Cytomegalovirus infection 67.33 11.15 11 209006 54433 110325849
Nail disorder 66.73 11.15 14 209003 57921 110322361
Adverse event 65.83 11.15 65 208952 108744 110271538
Lower limb fracture 65.72 11.15 30 208987 75318 110304964
Dyspnoea at rest 65.68 11.15 80 208937 8266 110372016
Pulmonary alveolar haemorrhage 65.27 11.15 128 208889 20022 110360260
Aspartate aminotransferase increased 65.23 11.15 127 208890 159809 110220473
Lower respiratory tract congestion 64.37 11.15 61 208956 4735 110375547
Prescribed underdose 63.31 11.15 22 208995 65152 110315130
Bone erosion 62.97 11.15 7 209010 46364 110333918
Knee arthroplasty 62.96 11.15 22 208995 64926 110315356
Acute respiratory failure 62.48 11.15 295 208722 74965 110305317
Arteriosclerosis 62.41 11.15 142 208875 24625 110355657
Lung disorder 62.39 11.15 566 208451 179481 110200801
Exostosis 62.25 11.15 7 209010 45949 110334333
Frequent bowel movements 61.37 11.15 29 208988 71361 110308921
Drug ineffective 60.55 11.15 2308 206709 1518232 108862050
Epilepsy 60.47 11.15 60 208957 100149 110280133
Drug resistance 60.23 11.15 16 209001 56358 110323924
Colitis ulcerative 59.79 11.15 36 208981 77327 110302955
Broncholithiasis 59.63 11.15 22 208995 270 110380012
Night sweats 58.54 11.15 102 208915 133881 110246401
Throat irritation 58.41 11.15 228 208789 53324 110326958
Humidity intolerance 57.83 11.15 25 208992 475 110379807
Sputum purulent 57.65 11.15 39 208978 1859 110378423
Seizure 57.55 11.15 219 208798 220966 110159316
Hip arthroplasty 57.48 11.15 17 209000 55796 110324486
Coeliac disease 57.44 11.15 7 209010 43180 110337102
Decreased activity 57.06 11.15 86 208931 10888 110369394
Vomiting 56.77 11.15 1300 207717 909375 109470907
Hyper IgE syndrome 56.46 11.15 27 208990 654 110379628
Paraesthesia 56.22 11.15 300 208717 276221 110104061
Aphonia 56.11 11.15 93 208924 12767 110367515
Rubber sensitivity 55.74 11.15 42 208975 2376 110377906
Smoke sensitivity 55.14 11.15 27 208990 690 110379592
Respiratory gas exchange disorder 55.01 11.15 29 208988 869 110379413
Exposure to allergen 54.90 11.15 25 208992 540 110379742
Musculoskeletal pain 54.52 11.15 171 208846 182852 110197430
Heart sounds 53.74 11.15 31 208986 1112 110379170
Frustration tolerance decreased 53.55 11.15 74 208943 8657 110371625
Pulmonary congestion 53.54 11.15 154 208863 30812 110349470
Transient ischaemic attack 53.26 11.15 251 208766 63731 110316551
Viral infection 52.98 11.15 220 208797 52919 110327363
Cholestasis 52.77 11.15 28 208989 64490 110315792
Creatinine renal clearance increased 52.30 11.15 48 208969 3577 110376705
Multiple sclerosis relapse 52.29 11.15 15 209002 50225 110330057
Bronchiolitis 52.17 11.15 58 208959 5435 110374847
Drug reaction with eosinophilia and systemic symptoms 52.06 11.15 47 208970 82048 110298234
Blood calcium increased 51.79 11.15 109 208908 17931 110362351
Injection site scab 51.70 11.15 25 208992 621 110379661
FEV1/FVC ratio decreased 51.70 11.15 20 208997 282 110380000
Status asthmaticus 51.52 11.15 29 208988 992 110379290
Ill-defined disorder 51.48 11.15 140 208877 156713 110223569
Amnesia 50.99 11.15 75 208942 105333 110274949
Joint injury 50.93 11.15 179 208838 39815 110340467
Hypothyroidism 50.82 11.15 272 208745 72627 110307655
Nodule 50.46 11.15 156 208861 32475 110347807
Leukopenia 50.20 11.15 131 208886 148660 110231622
Atrial fibrillation 49.94 11.15 658 208359 228984 110151298
Hepatitis 49.79 11.15 58 208959 89996 110290286
Rib deformity 49.31 11.15 18 208999 214 110380068
Multiple drug therapy 49.27 11.15 68 208949 7946 110372336
Rhinitis perennial 49.16 11.15 18 208999 216 110380066
Mucosal inflammation 48.90 11.15 66 208951 96075 110284207
Eosinophil count 48.85 11.15 17 209000 174 110380108
Jaundice cholestatic 48.78 11.15 94 208923 14514 110365768
Cardiac failure congestive 48.45 11.15 467 208550 150533 110229749
Oesophageal spasm 48.01 11.15 46 208971 3620 110376662
Hepatic function abnormal 47.79 11.15 59 208958 89236 110291046
Lupus-like syndrome 46.68 11.15 10 209007 40782 110339500
Sputum increased 46.68 11.15 56 208961 5695 110374587
Lung consolidation 46.03 11.15 76 208941 10400 110369882
Coma 46 11.15 96 208921 117773 110262509
Nasopharyngitis 45.82 11.15 1021 207996 393340 109986942
Nasal discharge discolouration 45.43 11.15 42 208975 3159 110377123
Toxicity to various agents 45.10 11.15 638 208379 479917 109900365
Onychomycosis 45.02 11.15 9 209008 38522 110341760
Muscle spasticity 44.99 11.15 7 209010 35908 110344374
Eye swelling 43.89 11.15 150 208867 32898 110347384
Lymph node calcification 43.21 11.15 20 208997 449 110379833
Schizophrenia 43.15 11.15 114 208903 21712 110358570
Memory impairment 42.66 11.15 209 208808 196735 110183547
Mycobacterium avium complex infection 42.51 11.15 54 208963 5823 110374459
Overdose 42.49 11.15 263 208754 233531 110146751
Finger deformity 42.49 11.15 6 209011 33086 110347196
Blood immunoglobulin E decreased 42.19 11.15 16 209001 213 110380069
Neoplasm progression 42.14 11.15 36 208981 64559 110315723
Sinus disorder 42.12 11.15 147 208870 32581 110347701
Perfume sensitivity 41.96 11.15 26 208991 1065 110379217
Dyspnoea paroxysmal nocturnal 41.81 11.15 36 208981 2466 110377816
Septic shock 41.60 11.15 155 208862 157373 110222909
Posterior reversible encephalopathy syndrome 41.52 11.15 7 209010 33854 110346428
CFTR gene mutation 40.89 11.15 16 209001 233 110380049
Snoring 40.86 11.15 57 208960 6727 110373555
Mycobacterial infection 40.86 11.15 46 208971 4371 110375911
Renal function test abnormal 40.80 11.15 66 208951 8880 110371402
Neuropathy peripheral 40.74 11.15 187 208830 179090 110201192
Hepatic cytolysis 40.64 11.15 27 208990 55026 110325256
Pneumothorax spontaneous 40.64 11.15 31 208986 1786 110378496
Increased viscosity of bronchial secretion 40.59 11.15 21 208996 605 110379677
Oesophageal pain 40.12 11.15 49 208968 5076 110375206
Cardio-respiratory arrest 39.83 11.15 101 208916 115735 110264547
Chronic sinusitis 39.80 11.15 121 208896 24963 110355319
Nocturnal dyspnoea 39.78 11.15 31 208986 1844 110378438
Underdose 39.57 11.15 37 208980 63517 110316765
Muscular weakness 39.42 11.15 291 208726 248177 110132105
Intentional self-injury 39.28 11.15 11 209006 37418 110342864
Hepatic cirrhosis 39.09 11.15 42 208975 67584 110312698
Respiratory distress 38.88 11.15 243 208774 68631 110311651
Carcinoid tumour pulmonary 38.82 11.15 18 208999 406 110379876
Rhonchi 38.33 11.15 45 208972 4473 110375809
Micturition urgency 38.28 11.15 101 208916 19219 110361063
Electrocardiogram QT prolonged 38.25 11.15 94 208923 108866 110271416
Increased bronchial secretion 38.04 11.15 42 208975 3906 110376376
Cardiogenic shock 37.35 11.15 32 208985 57306 110322976
Expiratory reserve volume decreased 36.85 11.15 13 209004 139 110380143
Capillaritis 36.57 11.15 33 208984 2406 110377876
Idiopathic intracranial hypertension 36.29 11.15 41 208976 3911 110376371
Aortic valve stenosis 36.25 11.15 52 208965 6298 110373984
Decreased appetite 36.20 11.15 657 208360 475189 109905093
Increased upper airway secretion 36.15 11.15 47 208970 5185 110375097
Forced expiratory volume abnormal 36.12 11.15 13 209004 148 110380134
Laryngeal stenosis 36.09 11.15 26 208991 1372 110378910
Injection site reaction 36.07 11.15 71 208946 88999 110291283
Skin candida 35.89 11.15 32 208985 2296 110377986
Diastolic dysfunction 35.67 11.15 75 208942 12329 110367953
Foot deformity 35.49 11.15 24 208993 48456 110331826
Neutrophil count decreased 35.30 11.15 114 208903 120827 110259455
Dyspepsia 35.12 11.15 214 208803 190751 110189531
Type 2 diabetes mellitus 35.06 11.15 194 208823 177038 110203244
Drug eruption 34.89 11.15 30 208987 53629 110326653
Eczema 34.73 11.15 245 208772 72048 110308234
Adverse reaction 34.39 11.15 7 209010 29587 110350695
Road traffic accident 34.39 11.15 97 208920 107301 110272981
Acute respiratory distress syndrome 34.28 11.15 30 208987 53168 110327114
Pyrexia 33.72 11.15 1372 207645 896893 109483389
Thrombotic microangiopathy 33.66 11.15 7 209010 29142 110351140
Gait inability 33.57 11.15 138 208879 136238 110244044
Aspiration 33.30 11.15 130 208887 30403 110349879
Diabetes mellitus 33.19 11.15 310 208707 99071 110281211
Drug tolerance decreased 33.09 11.15 6 209011 27534 110352748
Rib fracture 33.03 11.15 139 208878 33631 110346651
Hypoacusis 32.99 11.15 143 208874 35048 110345234
Decreased bronchial secretion 32.97 11.15 10 209007 63 110380219
Abdominal pain 32.53 11.15 730 208287 512259 109868023
Ageusia 32.33 11.15 96 208921 19549 110360733
Throat tightness 32.10 11.15 137 208880 33352 110346930
Laboratory test abnormal 32.03 11.15 22 208995 44057 110336225
Vision blurred 32.02 11.15 379 208638 128643 110251639
Adverse drug reaction 31.87 11.15 98 208919 105461 110274821
Ascites 31.84 11.15 81 208936 92727 110287555
Serotonin syndrome 31.74 11.15 39 208978 59114 110321168
Sepsis 31.61 11.15 432 208585 326914 110053368
Hypotension 31.16 11.15 1248 207769 522601 109857681
Acute hepatic failure 31.06 11.15 15 209002 36453 110343829
Hepatocellular injury 30.92 11.15 30 208987 50612 110329670
Brain natriuretic peptide abnormal 30.83 11.15 20 208997 888 110379394
Abdominal pain upper 30.81 11.15 469 208548 348642 110031640
Bronchomalacia 30.76 11.15 14 209003 302 110379980
Pain 30.44 11.15 1485 207532 953470 109426812
Therapy partial responder 30.43 11.15 16 209001 37045 110343237
Fibromuscular dysplasia 30.38 11.15 14 209003 311 110379971
FEV1/FVC ratio abnormal 30.33 11.15 9 209008 52 110380230
Bone marrow failure 30.14 11.15 39 208978 57809 110322473
Sputum retention 29.99 11.15 23 208994 1336 110378946
Chest pain 29.92 11.15 927 208090 375448 110004834
Hypertransaminasaemia 29.77 11.15 5 209012 24250 110356032
Joint stiffness 29.54 11.15 51 208966 67192 110313090
Amniotic fluid index increased 29.49 11.15 10 209007 94 110380188
Functional residual capacity increased 29.40 11.15 10 209007 95 110380187
Oropharyngeal discomfort 29.18 11.15 62 208955 10265 110370017
Sinus pain 29.06 11.15 45 208972 5834 110374448
Bacterial disease carrier 28.83 11.15 28 208989 2241 110378041
Carbon dioxide increased 28.70 11.15 31 208986 2813 110377469
Orthopnoea 28.67 11.15 64 208953 10957 110369325
Lung diffusion disorder 28.54 11.15 13 209004 281 110380001
Granulomatous rosacea 28.45 11.15 12 209005 214 110380068
Hypoglobulinaemia 28.30 11.15 12 209005 217 110380065
Product prescribing error 28.29 11.15 180 208837 51151 110329131
Transplant rejection 28.16 11.15 6 209011 24561 110355721
Pancreatitis 28.12 11.15 87 208930 93446 110286836
Exercise tolerance decreased 28.01 11.15 67 208950 12000 110368282
Eosinophilic bronchitis 27.84 11.15 16 209001 570 110379712
Sputum culture 27.72 11.15 13 209004 301 110379981
Nasal disorder 27.66 11.15 37 208980 4197 110376085
Dysarthria 27.66 11.15 75 208942 84046 110296236
Pleuritic pain 27.64 11.15 80 208937 16060 110364222
N-terminal prohormone brain natriuretic peptide abnormal 27.37 11.15 13 209004 310 110379972
Klebsiella infection 27.22 11.15 3 209014 20006 110360276
Device dislocation 27.06 11.15 13 209004 31691 110348591
Neurosensory hypoacusis 26.97 11.15 12 209005 245 110380037
Neurotoxicity 26.95 11.15 24 208993 42183 110338099
Product physical issue 26.95 11.15 40 208977 4996 110375286
Suffocation feeling 26.93 11.15 26 208991 2065 110378217
Pneumothorax 26.91 11.15 135 208882 35150 110345132
Lipohypertrophy 26.64 11.15 19 208998 987 110379295
Dyskinesia 26.48 11.15 35 208982 51411 110328871
Cytopenia 26.24 11.15 12 209005 30104 110350178
Liver function test increased 26.17 11.15 83 208934 88465 110291817
Bronchitis chronic 26.09 11.15 39 208978 4901 110375381
Ischaemic cardiomyopathy 26.08 11.15 51 208966 7960 110372322
Polyp 26.02 11.15 58 208959 9922 110370360
Pneumonia viral 25.96 11.15 62 208955 11095 110369187
Aplastic anaemia 25.78 11.15 7 209010 24301 110355981
Tumour lysis syndrome 25.73 11.15 13 209004 30788 110349494
Tympanosclerosis 25.66 11.15 8 209009 56 110380226
Renal impairment 25.62 11.15 230 208787 188215 110192067
Decreased gait velocity 25.59 11.15 11 209006 206 110380076
Premature delivery 25.48 11.15 13 209004 30619 110349663
Bronchospasm paradoxical 25.40 11.15 11 209006 210 110380072
Walking aid user 25.16 11.15 8 209009 25067 110355215
Blood lactate dehydrogenase increased 25.11 11.15 28 208989 44306 110335976
Epstein-Barr virus infection 25.01 11.15 3 209014 18735 110361547
Back injury 24.65 11.15 32 208985 47367 110332915
Sinus polyp degeneration 24.30 11.15 8 209009 68 110380214
Peritonitis 24.06 11.15 16 209001 32591 110347691
Nasal septum deviation 24.02 11.15 25 208992 2173 110378109
Oxygen saturation increased 23.85 11.15 16 209001 752 110379530
Abortion spontaneous 23.74 11.15 18 208999 34264 110346018
Convulsive threshold lowered 23.74 11.15 18 208999 1028 110379254
Pulmonary arterial hypertension 23.71 11.15 123 208894 32445 110347837
Feeling abnormal 23.59 11.15 476 208541 180235 110200047
Deep vein thrombosis 23.56 11.15 161 208856 139726 110240556
Prostatic adenoma 23.45 11.15 9 209008 124 110380158
Wrist fracture 23.30 11.15 70 208947 14347 110365935
Sputum abnormal 23.28 11.15 20 208997 1366 110378916
Poisoning 23.26 11.15 13 209004 29092 110351190
Palmar-plantar erythrodysaesthesia syndrome 23.14 11.15 26 208991 40999 110339283
Urinary retention 23.08 11.15 217 208800 69466 110310816
Eosinophilic pneumonia chronic 23.05 11.15 14 209003 553 110379729
Upper limb fracture 22.83 11.15 89 208928 20799 110359483
Acute myeloid leukaemia 22.78 11.15 23 208994 38087 110342195
Metastases to liver 22.74 11.15 20 208997 35366 110344916
Factor V Leiden mutation 22.54 11.15 11 209006 279 110380003
Use of accessory respiratory muscles 22.44 11.15 15 209002 701 110379581
Breath sounds 22.35 11.15 9 209008 142 110380140
Hallucination, auditory 22.26 11.15 11 209006 26386 110353896
Akathisia 22.21 11.15 3 209014 17110 110363172
Sinus congestion 22.15 11.15 115 208902 30344 110349938
Drug level increased 22.07 11.15 35 208982 47684 110332598
Blood alkaline phosphatase increased 22.02 11.15 65 208952 70870 110309412
Umbilical hernia 22.01 11.15 44 208973 6978 110373304
Vascular shunt 21.97 11.15 7 209010 53 110380229
Blood creatine phosphokinase increased 21.95 11.15 68 208949 73009 110307273
Foetal macrosomia 21.92 11.15 8 209009 95 110380187
Gout 21.89 11.15 131 208886 36435 110343847
Migraine 21.83 11.15 213 208804 171439 110208843
Hypoalbuminaemia 21.67 11.15 14 209003 28960 110351322
Anxiety 21.65 11.15 827 208190 344251 110036031
Nasal mucosal disorder 21.64 11.15 22 208995 1861 110378421
Diaphragmatic disorder 21.61 11.15 22 208995 1864 110378418
Asbestosis 21.57 11.15 9 209008 156 110380126
Medication error 21.57 11.15 114 208903 105252 110275030
Coagulation factor V level abnormal 21.52 11.15 9 209008 157 110380125
Toxic epidermal necrolysis 21.46 11.15 47 208970 56680 110323602
Lymphocyte count decreased 21.19 11.15 48 208969 57195 110323087
Lacrimal disorder 21.19 11.15 13 209004 523 110379759
Muscle spasms 21.15 11.15 384 208633 277773 110102509
Pneumocystis jirovecii pneumonia 21.06 11.15 30 208987 42705 110337577
Peak expiratory flow rate abnormal 21.00 11.15 8 209009 108 110380174
Infusion site reaction 20.93 11.15 4 209013 17678 110362604
Aortic aneurysm 20.88 11.15 53 208964 9851 110370431
Arthritis 20.88 11.15 209 208808 167377 110212905
Obesity 20.85 11.15 127 208890 113224 110267058
Fractured coccyx 20.82 11.15 18 208999 1240 110379042
Device difficult to use 20.74 11.15 5 209012 18800 110361482
Haemophilus infection 20.68 11.15 26 208991 2774 110377508
Tubulointerstitial nephritis 20.52 11.15 45 208972 54239 110326043
Affect lability 20.47 11.15 5 209012 18632 110361650
Lactic acidosis 20.38 11.15 98 208919 92713 110287569
Poor quality device used 20.22 11.15 26 208991 2837 110377445
Musculoskeletal discomfort 20.07 11.15 93 208924 23445 110356837
Hyponatraemia 20 11.15 546 208471 217107 110163175
Functional residual capacity decreased 20.00 11.15 7 209010 73 110380209
No adverse event 19.92 11.15 72 208945 73767 110306515
Metastases to bone 19.84 11.15 18 208999 31354 110348928
Proteinuria 19.82 11.15 28 208989 39990 110340292
Atheroembolism 19.71 11.15 11 209006 370 110379912
Factitious disorder 19.70 11.15 9 209008 196 110380086
Proctitis 19.68 11.15 4 209013 16923 110363359
Drug use disorder 19.55 11.15 5 209012 18069 110362213
Aptyalism 19.53 11.15 15 209002 873 110379409
Infection 19.51 11.15 528 208489 361672 110018610
Right ventricular systolic pressure 19.46 11.15 5 209012 15 110380267
Hypochromic anaemia 19.44 11.15 27 208990 3174 110377108
Blood immunoglobulin E abnormal 19.37 11.15 6 209011 41 110380241
Hernia pain 19.33 11.15 12 209005 493 110379789
Hypothermia 19.28 11.15 13 209004 26289 110353993
Skin ulcer 19.27 11.15 59 208958 63586 110316696
Hereditary haemorrhagic telangiectasia 19.12 11.15 7 209010 84 110380198
Hypersensitivity 18.99 11.15 600 208417 403398 109976884
Shock 18.98 11.15 46 208971 53542 110326740
Painful respiration 18.97 11.15 29 208988 3718 110376564
Left ventricular dilatation 18.92 11.15 18 208999 1404 110378878
Pathogen resistance 18.91 11.15 5 209012 17667 110362615
Eye disorder 18.90 11.15 106 208911 28800 110351482
Agranulocytosis 18.88 11.15 57 208960 61703 110318579
Pulmonary hypertension 18.81 11.15 173 208844 55047 110325235
Pulmonary fibrosis 18.79 11.15 284 208733 101758 110278524
Gingival bleeding 18.75 11.15 7 209010 19832 110360450
Encephalopathy 18.73 11.15 84 208933 80971 110299311
Mobility decreased 18.38 11.15 583 208434 236839 110143443
Diabetic ketoacidosis 18.38 11.15 32 208985 42026 110338256
Flour sensitivity 18.36 11.15 5 209012 20 110380262
Physiotherapy chest 18.33 11.15 4 209013 4 110380278
Incorrect dose administered 18.15 11.15 286 208731 103355 110276927
Menopausal symptoms 18.12 11.15 23 208994 2478 110377804
Blood uric acid increased 18.11 11.15 9 209008 21520 110358762
Lip pruritus 18.10 11.15 17 209000 1305 110378977
Inhalation therapy 17.93 11.15 6 209011 54 110380228
Cardiac failure 17.90 11.15 473 208544 187153 110193129
Lung neoplasm 17.85 11.15 44 208973 8032 110372250
Myelodysplastic syndrome 17.80 11.15 27 208990 37457 110342825
Hyperbilirubinaemia 17.78 11.15 19 208998 30652 110349630
Hemiparesis 17.77 11.15 35 208982 43868 110336414
Intervertebral disc protrusion 17.73 11.15 101 208916 27597 110352685
Rash maculo-papular 17.71 11.15 76 208941 74146 110306136
Hypophosphataemia 17.67 11.15 22 208995 33160 110347122
Tooth disorder 17.42 11.15 18 208999 29491 110350791
Respiratory tract inflammation 17.41 11.15 15 209002 1028 110379254
Sarcopenia 17.37 11.15 16 209001 1198 110379084
Peripheral sensory neuropathy 17.32 11.15 5 209012 16675 110363607
Device issue 17.26 11.15 24 208993 34511 110345771
Brain oedema 17.22 11.15 20 208997 31078 110349204
Drug tolerance 17.17 11.15 5 209012 16580 110363702
Lymphopenia 17.16 11.15 31 208986 40139 110340143
Blood immunoglobulin G decreased 17.12 11.15 34 208983 5366 110374916
Depressed mood 17.07 11.15 183 208834 60626 110319656
Dry throat 17.00 11.15 47 208970 9191 110371091
Hyperkaliuria 16.95 11.15 8 209009 188 110380094
Poisoning deliberate 16.78 11.15 15 209002 26316 110353966
Left-to-right cardiac shunt 16.76 11.15 8 209009 193 110380089
Electrocardiogram QRS complex abnormal 16.74 11.15 13 209004 769 110379513
Somnolence 16.70 11.15 431 208586 297018 110083264
Pulmonary embolism 16.69 11.15 527 208490 213947 110166335
Nervousness 16.61 11.15 123 208894 36728 110343554
Extrapyramidal disorder 16.60 11.15 18 208999 28849 110351433
Animal scratch 16.58 11.15 19 208998 1840 110378442
Pulmonary arterial pressure abnormal 16.51 11.15 14 209003 939 110379343
Renal tubular necrosis 16.45 11.15 20 208997 30455 110349827
Enterococcal infection 16.42 11.15 9 209008 20357 110359925
Hepatic haematoma 16.36 11.15 14 209003 951 110379331
Vaginal haemorrhage 16.32 11.15 14 209003 25060 110355222
Pustular psoriasis 16.27 11.15 3 209014 13602 110366680
Aphasia 16.27 11.15 57 208960 58940 110321342
Polycystic ovaries 16.18 11.15 31 208986 4765 110375517
Condition aggravated 16.17 11.15 1183 207834 733653 109646629
Nasal mucosal discolouration 16.16 11.15 6 209011 75 110380207
Hyposmia 16.14 11.15 15 209002 1136 110379146
Diffuse large B-cell lymphoma 16.08 11.15 5 209012 15893 110364389
Pickwickian syndrome 16.03 11.15 11 209006 537 110379745
Mastication disorder 15.99 11.15 26 208991 3512 110376770
Perennial allergy 15.83 11.15 4 209013 11 110380271
Pulmonary pain 15.77 11.15 36 208981 6257 110374025
Status epilepticus 15.72 11.15 22 208995 31549 110348733
Ankylosing spondylitis 15.63 11.15 5 209012 15607 110364675
Coagulation factor deficiency 15.60 11.15 9 209008 323 110379959
Panniculitis 15.59 11.15 5 209012 15577 110364705
Right ventricular failure 15.55 11.15 93 208924 25861 110354421
Allergic sinusitis 15.55 11.15 18 208999 1763 110378519
Respiratory tract haemorrhage 15.35 11.15 19 208998 1995 110378287
Coordination abnormal 15.34 11.15 15 209002 25213 110355069
Hyperglycaemia 15.30 11.15 96 208921 84994 110295288
Plasma cell myeloma 15.29 11.15 64 208953 62872 110317410
Idiopathic pulmonary fibrosis 15.26 11.15 31 208986 4973 110375309
Pneumococcal infection 15.24 11.15 18 208999 1801 110378481
Tremor 15.24 11.15 495 208522 201737 110178545
Eye allergy 15.23 11.15 14 209003 1045 110379237
Paraneoplastic rash 15.23 11.15 6 209011 89 110380193
Drug effective for unapproved indication 15.17 11.15 4 209013 14163 110366119
Atelectasis 15.13 11.15 120 208897 36592 110343690
Crepitations 15.11 11.15 50 208967 10785 110369497
Gamma-glutamyltransferase increased 15.11 11.15 62 208955 61247 110319035
Oxygen saturation abnormal 15.07 11.15 33 208984 5578 110374704
Blood phosphorus increased 15.05 11.15 6 209011 16334 110363948
Toxic encephalopathy 15.01 11.15 5 209012 15209 110365073
Xanthelasma 14.93 11.15 7 209010 162 110380120
Cardiac arrest 14.83 11.15 272 208745 196481 110183801
Dizziness exertional 14.70 11.15 12 209005 763 110379519
Magnesium metabolism disorder 14.65 11.15 5 209012 48 110380234
Impaired work ability 14.62 11.15 17 209000 26402 110353880
Blood immunoglobulin E 14.56 11.15 5 209012 49 110380233
Cough decreased 14.49 11.15 4 209013 17 110380265
Lip blister 14.45 11.15 24 208993 3301 110376981
Restlessness 14.43 11.15 56 208961 56203 110324079
Full blood count decreased 14.42 11.15 24 208993 32075 110348207
Altered state of consciousness 14.37 11.15 58 208959 57568 110322714
Lower gastrointestinal haemorrhage 14.29 11.15 71 208946 18415 110361867
Uveitis 14.28 11.15 12 209005 21698 110358584
Torsade de pointes 14.25 11.15 13 209004 22587 110357695
Pancreatitis relapsing 14.25 11.15 16 209001 1516 110378766
Steroid diabetes 14.22 11.15 31 208986 5223 110375059
Choking sensation 14.15 11.15 28 208989 4408 110375874
Chronic respiratory failure 14.13 11.15 26 208991 3877 110376405
Pneumonitis 14.09 11.15 213 208804 76318 110303964
Pulmonary toxicity 14.08 11.15 8 209009 17738 110362544
Pharyngeal oedema 14.08 11.15 65 208952 16363 110363919
Lung carcinoma cell type unspecified recurrent 13.95 11.15 9 209008 396 110379886
Colitis 13.85 11.15 125 208892 102198 110278084
Respiratory arrest 13.72 11.15 60 208957 58239 110322043
Fatigue 13.72 11.15 2053 206964 1213905 109166377
Metastases to lung 13.69 11.15 14 209003 23049 110357233
Respiratory syncytial virus infection 13.68 11.15 59 208958 14425 110365857
Oxygen consumption increased 13.67 11.15 32 208985 5653 110374629
Generalised tonic-clonic seizure 13.66 11.15 55 208962 54625 110325657
Rheumatoid nodule 13.62 11.15 11 209006 20285 110359997
Heavy menstrual bleeding 13.53 11.15 7 209010 16358 110363924
Anosmia 13.52 11.15 53 208964 12419 110367863
Eye infection bacterial 13.45 11.15 9 209008 421 110379861
Disseminated intravascular coagulation 13.43 11.15 37 208980 41249 110339033
Musculoskeletal chest pain 13.41 11.15 97 208920 28750 110351532
Cataract 13.41 11.15 218 208799 79267 110301015
Coronary artery disease 13.38 11.15 200 208817 71490 110308792
Hilar lymphadenopathy 13.36 11.15 19 208998 2283 110377999
Haematocrit decreased 13.27 11.15 72 208945 66045 110314237
Anti factor V antibody 13.22 11.15 8 209009 314 110379968
Caffeine allergy 13.22 11.15 4 209013 25 110380257
Musculoskeletal disorder 13.18 11.15 14 209003 22650 110357632
Scratch 13.14 11.15 54 208963 12925 110367357
Exposure to toxic agent 13.09 11.15 4 209013 12854 110367428
Forced expiratory volume increased 13.08 11.15 6 209011 132 110380150
Rash papular 13.04 11.15 20 208997 27619 110352663
Accidental overdose 13.04 11.15 52 208965 51782 110328500
Tendon rupture 13.04 11.15 57 208960 14021 110366261
Anal abscess 13.02 11.15 3 209014 11635 110368647
Renal artery angioplasty 12.95 11.15 4 209013 27 110380255
Enterobiasis 12.89 11.15 5 209012 71 110380211
Tendonitis 12.88 11.15 89 208928 25994 110354288
Caesarean section 12.85 11.15 5 209012 13812 110366470
Cardiac failure chronic 12.85 11.15 56 208961 13755 110366527
Skin necrosis 12.84 11.15 13 209004 21499 110358783
Anaemia 12.80 11.15 876 208141 546210 109834072
Laziness 12.79 11.15 12 209005 920 110379362
Lymphoedema 12.74 11.15 59 208958 14870 110365412
Hyperammonaemia 12.72 11.15 5 209012 13727 110366555
Lung hernia 12.71 11.15 5 209012 74 110380208
Abnormal behaviour 12.69 11.15 35 208982 39004 110341278
Synovial cyst 12.68 11.15 3 209014 11427 110368855
Blood thyroid stimulating hormone abnormal 12.63 11.15 13 209004 1116 110379166
Inappropriate antidiuretic hormone secretion 12.53 11.15 108 208909 33743 110346539
Rash vesicular 12.52 11.15 6 209011 14646 110365636
Laryngectomy 12.48 11.15 4 209013 31 110380251
Small airways disease 12.47 11.15 5 209012 78 110380204
Drug dose omission by device 12.32 11.15 6 209011 14510 110365772
Tachyarrhythmia 12.32 11.15 39 208978 8222 110372060
Abnormal loss of weight 12.28 11.15 45 208972 10212 110370070
Hypercalcaemia 12.25 11.15 46 208971 46611 110333671
Claustrophobia 12.21 11.15 15 209002 1564 110378718
Ataxia 12.19 11.15 24 208993 30084 110350198
Intestinal perforation 12.11 11.15 13 209004 20931 110359351
Enteritis 12.10 11.15 11 209006 19145 110361137
Squamous cell carcinoma of lung 12.10 11.15 20 208997 2739 110377543
Post procedural infection 12.10 11.15 55 208962 13754 110366528
Upper respiratory tract congestion 12.08 11.15 21 208996 2996 110377286
Cystitis haemorrhagic 12.07 11.15 4 209013 12205 110368077
COVID-19 11.98 11.15 362 208655 244698 110135584
Nasal inflammation 11.94 11.15 12 209005 1001 110379281
Functional residual capacity abnormal 11.94 11.15 3 209014 8 110380274
Pulmonary function test increased 11.94 11.15 3 209014 8 110380274
Sinus polyp 11.92 11.15 10 209007 661 110379621
Measles 11.92 11.15 10 209007 661 110379621
Immune thrombocytopenia 11.89 11.15 15 209002 22479 110357803
Product taste abnormal 11.87 11.15 19 208998 2533 110377749
Paraesthesia oral 11.85 11.15 29 208988 33642 110346640
Starvation 11.84 11.15 12 209005 1011 110379271
Progressive multifocal leukoencephalopathy 11.83 11.15 18 208999 24938 110355344
Occupational exposure to air contaminants 11.82 11.15 6 209011 166 110380116
Oral candidiasis 11.78 11.15 133 208884 44627 110335655
Peripheral swelling 11.73 11.15 634 208383 403400 109976882
Drug withdrawal syndrome 11.72 11.15 35 208982 38019 110342263
Arthritis bacterial 11.69 11.15 3 209014 10817 110369465
Gastric cyst 11.66 11.15 5 209012 93 110380189
Injection site hypoaesthesia 11.66 11.15 10 209007 681 110379601
Mental status changes 11.66 11.15 90 208927 76032 110304250
Graft versus host disease 11.64 11.15 11 209006 18795 110361487
Lung cancer metastatic 11.63 11.15 25 208992 4173 110376109
Mononeuropathy multiplex 11.63 11.15 11 209006 852 110379430
Intervertebral disc degeneration 11.61 11.15 66 208951 18019 110362263
Joint dislocation 11.60 11.15 30 208987 34160 110346122
Laryngeal pain 11.60 11.15 31 208986 5944 110374338
Croup infectious 11.58 11.15 12 209005 1038 110379244
Breast neoplasm 11.50 11.15 12 209005 1046 110379236
Nasal dryness 11.48 11.15 30 208987 5676 110374606
International normalised ratio increased 11.46 11.15 229 208788 86543 110293739
Gastrointestinal angiectasia 11.45 11.15 8 209009 402 110379880
Blood pressure systolic 11.42 11.15 5 209012 98 110380184
Personality disorder 11.37 11.15 5 209012 12832 110367450
Contusion 11.34 11.15 345 208672 233016 110147266
Respiratory acidosis 11.33 11.15 54 208963 13772 110366510
Immunosuppressant drug level increased 11.31 11.15 4 209013 11720 110368562
Autoimmune haemolytic anaemia 11.29 11.15 3 209014 10564 110369718
Herpes simplex 11.28 11.15 8 209009 15756 110364526
Brain hypoxia 11.26 11.15 13 209004 1269 110379013
Peak expiratory flow rate increased 11.22 11.15 3 209014 11 110380271
Bronchitis haemophilus 11.22 11.15 3 209014 11 110380271
Hyperaesthesia 11.17 11.15 7 209010 14720 110365562
Diastolic hypertension 11.15 11.15 5 209012 104 110380178

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R03AL06 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC R03AL10 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC R03BB04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Anticholinergics
ATC R03BB54 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Anticholinergics
FDA MoA N0000175370 Cholinergic Antagonists
FDA EPC N0000175574 Anticholinergic
MeSH PA D001993 Bronchodilator Agents
MeSH PA D010276 Parasympatholytics
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018678 Cholinergic Agents
MeSH PA D018680 Cholinergic Antagonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:35523 bronchodilator agent
CHEBI has role CHEBI:48876 muscarinic antagonist

Related Drugs by ATC class:

R03AL Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids 14 drugs
aclidinium bromidebeclometasone dipropionatebudesonidefenoterolfluticasone furoateformoterolglycopyrronium bromideindacaterolipratropiummometasone furoateolodaterolsalbutamol show all 14 →
R03BB Anticholinergics 6 drugs
aclidinium bromideglycopyrronium bromideipratropiumoxitropiumrevefenacinumeclidinium

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Chronic bronchitis indication 63480004 DOID:6132
Pulmonary emphysema indication 87433001
Asthma indication 195967001 DOID:2841
Bronchospasm Prevention with COPD indication
Chronic Obstructive Pulmonary Disease with Bronchospasms indication
Impaired renal function disorder contraindication 197663003
Bladder outflow obstruction contraindication 236645006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.97 acidic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 0.018MG BASE/INH SPIRIVA BOEHRINGER INGELHEIM N021395 Jan. 30, 2004 RX POWDER INHALATION 8022082 Jan. 19, 2026 ADMINISTRATION OF AN INHALABLE POWDER COMPRISING TIOTROPIUM VIA DEVICE

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ANTAGONIST Ki 11.10 WOMBAT-PK CHEMBL
Histamine H1 receptor GPCR Ki 7.68 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 11 WOMBAT-PK
Muscarinic acetylcholine receptor M2 GPCR Ki 11 WOMBAT-PK
Muscarinic acetylcholine receptor M4 GPCR Ki 11 WOMBAT-PK
Muscarinic acetylcholine receptor M5 GPCR Ki 11 WOMBAT-PK
Translocator protein Transporter Ki 5.37 CHEMBL
Transmembrane protein 97 Enzyme Ki 5.69 CHEMBL
Muscarinic acetylcholine receptor M2 GPCR Ki 9.82 CHEMBL
Muscarinic acetylcholine receptor M1 GPCR Ki 9.80 CHEMBL
Muscarinic acetylcholine receptor M3 GPCR Ki 9.52 CHEMBL

External reference:

IDSource
4021416 VUID
N0000148830 NUI
411207-31-3 SECONDARY_CAS_RN
4021416 VANDF
CHEBI:90959 CHEBI
0HK PDB_CHEM_ID
CHEMBL3545181 ChEMBL_ID
CHEMBL1900528 ChEMBL_ID
DB01409 DRUGBANK_ID
1298831 RXNORM
17045 MMSL
232703 MMSL
31060 MMSL
45574 MMSL
d04829 MMSL
009712 NDDF
009713 NDDF
407730002 SNOMEDCT_US
409169006 SNOMEDCT_US
425812008 SNOMEDCT_US
734451000 SNOMEDCT_US
C1306772 UMLSCUI
D000069447 MESH_DESCRIPTOR_UI
5487426 PUBCHEM_CID
367 IUPHAR_LIGAND_ID
0EB439235F UNII
0EB439235F INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
SpirivaHandiHaler HUMAN PRESCRIPTION DRUG LABEL 1 0597-0075 CAPSULE 18 ug ORAL NDA 30 sections
Stiolto Respimat HUMAN PRESCRIPTION DRUG LABEL 2 0597-0155 SPRAY, METERED 3.12 ug RESPIRATORY (INHALATION) NDA 31 sections
Spiriva HandiHaler HUMAN PRESCRIPTION DRUG LABEL 1 50090-4248 CAPSULE 18 ug ORAL NDA 29 sections
Spiriva HUMAN PRESCRIPTION DRUG LABEL 1 50090-4414 CAPSULE 18 ug ORAL NDA 29 sections
Spiriva HandiHaler HUMAN PRESCRIPTION DRUG LABEL 1 50090-7645 CAPSULE 18 ug ORAL NDA 29 sections
Spiriva HUMAN PRESCRIPTION DRUG LABEL 1 54868-5109 CAPSULE 18 ug ORAL NDA 29 sections
Tiotropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 68180-964 CAPSULE 18 ug ORAL ANDA 24 sections
Tiotropium Bromide HUMAN PRESCRIPTION DRUG LABEL 1 68180-964 CAPSULE 18 ug ORAL ANDA 24 sections