AI ASSISTANT
Ask DrugCentral
Explore drug properties, targets, and indications with answers grounded in DrugCentral.
Powered by DrugCentral + retrieval-augmented AIYour question
Ask in your own words. Each question is answered independently.
Explore sample questions
Select a question to fill the editor, then ask it or make it your own.
DrugCentral answer
Your answer will appear here. Open linked drug cards in a new tab to explore the source details.
About Ask DrugCentral
Ask DrugCentral helps you explore drug properties, biological targets, and indications using natural language. Sample questions offer starting points, and linked drug cards let you check the underlying records.
General architecture
- Ask a questionThe browser sends your question to the same-origin Django chat API.
- Retrieve and generateThe API forwards the question to the configured DrugCentral retrieval-augmented generation (RAG) service, which returns an AI-generated answer.
- Explore the answerThe app resolves cited drug-card names and displays the answer with links to drug records.
Using the assistant
Each request is independent; previous questions are not sent as conversation history. You can edit a sample before submitting, retry a failed request, or switch back to normal search. Drug links open in a new tab so your question and answer stay available.
Answers may contain mistakes or omit information. Verify details against DrugCentral records and original sources.
AI can make mistakes. Verify answers against the original sources before relying on them.
sulfadimethoxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-infectives, sulfonamides | 2501 | 122-11-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A sulfanilamide that is used as an anti-infective agent.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.50 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 59.10 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPK9,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK | 46 | |||
| kinase-selectivity-class | ACVR2A,AURKA,AXL,CDK16,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,JAK1,MAP2K3,MAP2K6,MAP3K21,MAP4K1,MAPK7,MARK4,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 | 25 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01ED01 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE SULFONAMIDES AND TRIMETHOPRIM Long-acting sulfonamides |
| MeSH PA | D000890 | Anti-Infective Agents |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
| CHEBI has role | CHEBI:88188 | drug allergen |
Related Drugs by ATC class:
J01ED Long-acting sulfonamides 8 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Respiratory genitourinary tract infections caused by Streptococci | Indication |
| Cats | Respiratory genitourinary tract infections caused by Staphylococci | Indication |
| Cats | Respiratory genitourinary tract infections caused by Escherichia | Indication |
| Cats | Respiratory genitourinary tract infections caused by Salmonella | Indication |
| Cats | Respiratory genitourinary tract infections caused by Klebsiella | Indication |
| Cats | Respiratory genitourinary tract infections caused by Proteus | Indication |
| Cats | Respiratory genitourinary tract infections caused by Shigella | Indication |
| Cats | Enteric infections caused by Streptococci | Indication |
| Cats | Enteric infections caused by Staphylococci | Indication |
| Cats | Enteric infections caused by Escherichia | Indication |
| Cats | Enteric infections caused by Salmonella | Indication |
| Cats | Enteric infections caused by Klebsiella | Indication |
| Cats | Enteric infections caused by Proteus | Indication |
| Cats | Enteric infections caused by Shigella | Indication |
| Cats | Soft tissue infections infections caused by Streptococci | Indication |
| Cats | Soft tissue infections infections caused by Staphylococci | Indication |
| Cats | Soft tissue infections infections caused by Escherichia | Indication |
| Cats | Soft tissue infections infections caused by Salmonella | Indication |
| Cats | Soft tissue infections infections caused by Klebsiella | Indication |
| Cats | Soft tissue infections infections caused by Proteus | Indication |
| Cats | Soft tissue infections infections caused by Shigella | Indication |
| Cats | Bacterial enteritis associated with coccidiosis | Indication |
| Cats | Bacterial enteritis associated with Salmonellosis | Indication |
| Cattle | Shipping fever complex | Indication |
| Cattle | Bacterial pneumonia associated with Pasteurella spp | Indication |
| Cattle | Diphtheria | Indication |
| Cattle | Necrotic pododermatitis (foot rot) caused by Fusobacterium necrophorum | Indication |
| Chickens | Coccidiosis | Indication |
| Chickens | Cholera | Indication |
| Chickens | Coryza | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Streptococci | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Staphylococci | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Escherichia | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Salmonella | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Klebsiella | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Proteus | Indication |
| Dogs | Respiratory genitourinary tract infections caused by Shigella | Indication |
| Dogs | Enteric infections caused by Streptococci | Indication |
| Dogs | Enteric infections caused by Staphylococci | Indication |
| Dogs | Enteric infections caused by Escherichia | Indication |
| Dogs | Enteric infections caused by Salmonella | Indication |
| Dogs | Enteric infections caused by Klebsiella | Indication |
| Dogs | Enteric infections caused by Proteus | Indication |
| Dogs | Enteric infections caused by Shigella | Indication |
| Dogs | Soft tissue infections infections caused by Streptococci | Indication |
| Dogs | Soft tissue infections infections caused by Staphylococci | Indication |
| Dogs | Soft tissue infections infections caused by Escherichia | Indication |
| Dogs | Soft tissue infections infections caused by Salmonella | Indication |
| Dogs | Soft tissue infections infections caused by Klebsiella | Indication |
| Dogs | Soft tissue infections infections caused by Proteus | Indication |
| Dogs | Soft tissue infections infections caused by Shigella | Indication |
| Dogs | Bacterial enteritis associated with coccidiosis | Indication |
| Dogs | Bacterial enteritis associated with Salmonellosis | Indication |
| Horses | Respiratory disease caused by Streptococcus equi (strangles) | Indication |
| Turkeys | Coccidiosis | Indication |
| Turkeys | Cholera | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Bactrovet Tablets 250 mg | Intervet Inc. | 1 |
| Albon Tablets | Zoetis Inc. | 1 |
| AGRIBON Concentrated Solution 12.5%, ALBON Concentrated Solution 12.5% | Zoetis Inc. | 1 |
| Albon, Agribon Boluses - 2.5, Agribon Boluses - 5.0, Agribon Boluses - 15.0 | Zoetis Inc. | 1 |
| Bactrovet Oral Suspension 12.5% | Intervet Inc. | 1 |
| Rofenaid 40 | Zoetis Inc. | 2 |
| Agribon Injection 40%, Albon | Zoetis Inc. | 1 |
| Albon Oral Suspension 5% | Zoetis Inc. | 1 |
| Albon | Zoetis Inc. | 1 |
| Albon S.R. (Sustained Release) | Zoetis Inc. | 1 |
| Medacide-SDM Injection 10% | Cronus Pharma Specialities India Private Limited | 1 |
| Primor Tablets | Zoetis Inc. | 2 |
| Romet-30 | Pharmaq AS | 2 |
| DI-METHOX | Huvepharma EOOD | 1 |
| DI-METHOX | Huvepharma EOOD | 1 |
| Di-Methox Injection 40%, Sulfadimethoxine Injection 40% | Huvepharma EOOD | 1 |
| Sulfadimethoxine Concentrated Solution 12.5% | Cronus Pharma Specialities India Private Limited | 1 |
| Sulfadimethoxine Injection 40% | Huvepharma EOOD | 1 |
| Sulfadimethoxine 12.5% Oral Solution | Huvepharma EOOD | 1 |
| Sulfasol Soluble Powder | Med-Pharmex Inc. | 1 |
| Sulforal | Med-Pharmex Inc. | 1 |
| Sulfadimethoxine Soluble Powder | Phibro Animal Health Corp. | 1 |
| Sulfamed-G | Bimeda Animal Health Limited | 1 |
| Sulfadimethoxine Soluble Powder | First Priority Inc. | 1 |
| SulfaMed | Bimeda Animal Health Limited | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.93 | acidic |
| pKa2 | 1.99 | Basic |
| pKa3 | 0.4 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 6 | GPCR | Ki | 6.21 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| N0000166864 | NUI |
| D01142 | KEGG_DRUG |
| C0038676 | UMLSCUI |
| CHEBI:32161 | CHEBI |
| CHEMBL62193 | ChEMBL_ID |
| DB06150 | DRUGBANK_ID |
| D013412 | MESH_DESCRIPTOR_UI |
| 5323 | PUBCHEM_CID |
| 12638 | IUPHAR_LIGAND_ID |
| 840 | INN_ID |
| 30CPC5LDEX | UNII |
| 10172 | RXNORM |
| 002825 | NDDF |
| 387279005 | SNOMEDCT_US |
| 51013009 | SNOMEDCT_US |
Pharmaceutical products:
None