AI ASSISTANT
Ask DrugCentral
Explore drug properties, targets, and indications with answers grounded in DrugCentral.
Powered by DrugCentral + retrieval-augmented AIYour question
Ask in your own words. Each question is answered independently.
Explore sample questions
Select a question to fill the editor, then ask it or make it your own.
DrugCentral answer
Your answer will appear here. Open linked drug cards in a new tab to explore the source details.
About Ask DrugCentral
Ask DrugCentral helps you explore drug properties, biological targets, and indications using natural language. Sample questions offer starting points, and linked drug cards let you check the underlying records.
General architecture
- Ask a questionThe browser sends your question to the same-origin Django chat API.
- Retrieve and generateThe API forwards the question to the configured DrugCentral retrieval-augmented generation (RAG) service, which returns an AI-generated answer.
- Explore the answerThe app resolves cited drug-card names and displays the answer with links to drug records.
Using the assistant
Each request is independent; previous questions are not sent as conversation history. You can edit a sample before submitting, retry a failed request, or switch back to normal search. Drug links open in a new tab so your question and answer stay available.
Answers may contain mistakes or omit information. Verify details against DrugCentral records and original sources.
AI can make mistakes. Verify answers against the original sources before relying on them.
rimantadine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| adamantane derivatives | 2383 | 13392-28-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.20 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 20 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 15.93 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AKT2,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,EIF2AK3,EPHB4,ERBB2,GRK2,IRAK4,ITK,JAK3,MAP2K6,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK2,PDK4,PIM2,PRKDC,TEK,TGFBR1 | 29 | |||
| kinase-selectivity-class | EIF2AK3 | 1 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 17, 1993 | FDA | CARACO |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J05AC02 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIVIRALS FOR SYSTEMIC USE DIRECT ACTING ANTIVIRALS Cyclic amines |
| FDA MoA | N0000175542 | M2 Protein Inhibitors |
| FDA EPC | N0000175543 | Influenza A M2 Protein Inhibitor |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000998 | Antiviral Agents |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D019384 | Nucleic Acid Synthesis Inhibitors |
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
Related Drugs by ATC class:
J05AC Cyclic amines 1 drug
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Influenza due to Influenza A virus | indication | 442438000 | |
| Influenza A Prevention | indication | ||
| Acute nephropathy | contraindication | 58574008 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Seizure disorder | contraindication | 128613002 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.41 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Solute carrier family 22 member 2 | Transporter | IC50 | 5.36 | CHEMBL | |||||
| Multidrug and toxin extrusion protein 1 | Transporter | IC50 | 5.14 | CHEMBL | |||||
| Matrix protein 2 | Ion channel | INHIBITOR | CHEMBL | CHEMBL | |||||
| Polymerase acidic protein | Enzyme | IC50 | 4.96 | CHEMBL | |||||
| Matrix protein 2 | Ion channel | Kd | 7.80 | CHEMBL | |||||
| Matrix protein 2 | Ion channel | Kd | 6.29 | CHEMBL | |||||
| Matrix protein 2 | Ion channel | WOMBAT-PK | |||||||
| Matrix protein 2 | Ion channel | Kd | 7.80 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4023897 | VUID |
| N0000021902 | NUI |
| D00901 | KEGG_DRUG |
| 1501-84-4 | SECONDARY_CAS_RN |
| 4020839 | VANDF |
| 4023897 | VANDF |
| C0035629 | UMLSCUI |
| CHEBI:49886 | CHEBI |
| RIM | PDB_CHEM_ID |
| CHEMBL959 | ChEMBL_ID |
| DB00478 | DRUGBANK_ID |
| CHEMBL535396 | ChEMBL_ID |
| D012299 | MESH_DESCRIPTOR_UI |
| 5071 | PUBCHEM_CID |
| 2292 | INN_ID |
| 0T2EF4JQTU | UNII |
| 82093 | RXNORM |
| 42407 | MMSL |
| 5426 | MMSL |
| d03158 | MMSL |
| 004382 | NDDF |
| 004383 | NDDF |
| 108712009 | SNOMEDCT_US |
| 108713004 | SNOMEDCT_US |
| 372532009 | SNOMEDCT_US |
| 0T2EF4JQTU | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Rimantadine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0115-1911 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 21 sections |
| Rimantadine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-202 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 24 sections |
| Rimantadine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 52959-305 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 24 sections |
| Rimantadine Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68151-2103 | TABLET, FILM COATED | 100 mg | ORAL | ANDA | 24 sections |