nystatin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, polyene derivatives 1977 1400-61-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nystatin A1
  • nystatin
  • nystatine
Macrolide antifungal antibiotic complex produced by Streptomyces noursei, S. aureus, and other Streptomyces species. The biologically active components of the complex are nystatin A1, A2, and A3.
  • Molecular weight: 926.11
  • Formula: C47H75NO17
  • CLOGP: -3.20
  • LIPINSKI: 3
  • HAC: 18
  • HDO: 12
  • TPSA: 319.61
  • ALOGS: -4.03
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 MU O
0.10 MU V

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 0.11 mg/mL Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.588 High 0.88
caco2-efflux Caco-2 efflux ratio (BA/AB) 8.204 High 0.88
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.665 10^-6 cm/s High 0.88
dh-clint Dog hepatocyte intrinsic clearance 4.853 uL/min/10^6 cells High 0.88
dppb Dog plasma protein binding (% unbound) 10.300 % High 0.88
fcs-ppb Fetal calf serum protein binding (% unbound) 34.990 % High 0.88
herg hERG pIC50 4.466 pIC50 High 0.88
hh-clint Human hepatocyte intrinsic clearance 1.758 uL/min/10^6 cells High 0.88
hlm-clint Human liver microsomal intrinsic clearance 4.477 uL/min/mg protein High 0.88
hppb Human plasma protein binding (% unbound) 14.890 % High 0.88
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAPK7,NTRK2,PDK1,PDK2,PDK4,PRKDC,TEK,TGFBR1,ZAP70 20
kinase-selectivity-class MAP2K6 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.265 High 0.88
mh-clint Mouse hepatocyte intrinsic clearance 5.105 High 0.88
mppb Mouse plasma protein binding (% unbound) 11.440 High 0.88
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 4.688 High 0.88
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 17.710 % High 0.88
rh-clint Rat hepatocyte intrinsic clearance 8.279 uL/min/10^6 cells High 0.88
rh-fuinc Rat hepatocyte fraction unbound in incubation 56.300 % High 0.88
rppb Rat plasma protein binding (% unbound) 22.750 % High 0.88
solubility-dd Solubility at pH 7.4 in DMSO 816.582 uM High 0.88

Approvals:

DateAgencyCompanyOrphan
July 8, 1964 FDA DELCOR ASSET CORP

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Schizophrenia 494.01 9.85 217 51673 14697 90561860
Hypomania 383.11 9.85 156 51734 8741 90567816
Jaundice cholestatic 364.87 9.85 156 51734 9887 90566670
Cholelithiasis 274.59 9.85 233 51657 52273 90524284
Nasal polyps 253.25 9.85 124 51766 10756 90565801
Febrile neutropenia 229.17 9.85 361 51529 157988 90418569
Blood bilirubin increased 227.48 9.85 193 51697 43277 90533280
Asthma-chronic obstructive pulmonary disease overlap syndrome 207.83 9.85 85 51805 4814 90571743
Candida infection 204.94 9.85 164 51726 33893 90542664
Total lung capacity increased 202.42 9.85 84 51806 4937 90571620
Psychotic disorder 195.66 9.85 154 51736 31076 90545481
Pneumonia 178.63 9.85 780 51110 637279 89939278
Hepatotoxicity 166.61 9.85 166 51724 45676 90530881
Sarcoidosis 158.26 9.85 90 51800 10583 90565974
Hand deformity 150.96 9.85 4 51886 296358 90280199
Contraindicated product administered 138.87 9.85 12 51878 320127 90256430
Oral candidiasis 135.55 9.85 132 51758 35323 90541234
Maternal exposure during pregnancy 135.26 9.85 22 51868 360041 90216516
Systemic lupus erythematosus 133.98 9.85 23 51867 361873 90214684
Pericarditis 132.73 9.85 5 51885 270146 90306411
Pemphigus 132.08 9.85 16 51874 326848 90249709
Sepsis 130.68 9.85 306 51584 179508 90397049
Rhinitis allergic 127.77 9.85 93 51797 16692 90559865
Synovitis 126.45 9.85 19 51871 329733 90246824
Drug ineffective 126.17 9.85 392 51498 1383906 89192651
Arthropathy 117.84 9.85 32 51858 366210 90210347
Chronic obstructive pulmonary disease 116.06 9.85 175 51715 73654 90502903
Duodenal ulcer perforation 112.62 9.85 3 51887 221285 90355272
Cardiac murmur 110.26 9.85 88 51802 18106 90558451
Salpingo-oophorectomy unilateral 106.53 9.85 34 51856 934 90575623
Helicobacter infection 105.58 9.85 6 51884 226844 90349713
Bronchiectasis 104.39 9.85 93 51797 22237 90554320
Wound 104.22 9.85 23 51867 302957 90273600
Sputum increased 101.05 9.85 44 51846 2913 90573644
Sinusitis fungal 100.44 9.85 39 51851 1925 90574632
Rheumatoid arthritis 100.38 9.85 41 51849 362573 90213984
Glossodynia 98.22 9.85 31 51859 321748 90254809
Fungal infection 95.54 9.85 120 51770 42541 90534016
Drug intolerance 94.47 9.85 71 51819 447520 90129037
Hiatus hernia 92.43 9.85 92 51798 25269 90551288
Treatment failure 91.48 9.85 30 51860 303898 90272659
Folliculitis 87.66 9.85 8 51882 204345 90372212
Mucosal inflammation 86.90 9.85 134 51756 57491 90519066
Infusion related reaction 84.29 9.85 69 51821 416711 90159846
Embolism venous 83.46 9.85 41 51849 3579 90572978
Respiratory symptom 82.92 9.85 43 51847 4209 90572348
Lung neoplasm malignant 79.28 9.85 83 51807 24190 90552367
Therapeutic product effect decreased 79.07 9.85 30 51860 277541 90299016
Rheumatoid factor positive 78.47 9.85 5 51885 171645 90404912
Muscle injury 78.28 9.85 6 51884 176648 90399909
Joint swelling 77.49 9.85 105 51785 503195 90073362
Nausea 74.97 9.85 966 50924 1109350 89467207
Oedema peripheral 74.65 9.85 319 51571 257596 90318961
Abdominal discomfort 74.06 9.85 99 51791 477229 90099328
Discomfort 72.74 9.85 33 51857 274302 90302255
Urinary tract infection 72.14 9.85 356 51534 305276 90271281
Rheumatic fever 71.39 9.85 4 51886 153117 90423440
Toxic epidermal necrolysis 67.32 9.85 88 51802 32440 90544117
Diastolic dysfunction 65.95 9.85 45 51845 7288 90569269
Impaired healing 65.55 9.85 26 51864 234173 90342384
Musculoskeletal stiffness 63.86 9.85 46 51844 296486 90280071
General physical health deterioration 63.25 9.85 66 51824 355049 90221508
Vomiting 62.28 9.85 707 51183 787586 89788971
Type 2 diabetes mellitus 61.24 9.85 20 51870 203224 90373333
Blood cholesterol increased 60.03 9.85 22 51868 207990 90368567
Irritable bowel syndrome 58.10 9.85 23 51867 207425 90369132
Emphysema 57.56 9.85 51 51839 12104 90564453
Alopecia 57.18 9.85 124 51766 494947 90081610
Neutropenia 56.66 9.85 267 51623 224637 90351920
Completed suicide 56.39 9.85 8 51882 145050 90431507
BK virus infection 56.32 9.85 34 51856 4464 90572093
Fibromyalgia 55.94 9.85 24 51866 206245 90370312
Liver injury 54.62 9.85 15 51875 170552 90406005
Cellulitis 54.23 9.85 144 51746 91193 90485364
Obstructive airways disorder 53.56 9.85 70 51820 25799 90550758
Respiratory failure 53.25 9.85 169 51721 118249 90458308
Sleep disorder due to general medical condition, insomnia type 52.68 9.85 6 51884 128688 90447869
Cough 51.72 9.85 375 51515 368587 90207970
Exposure during pregnancy 50.00 9.85 38 51852 238372 90338185
Psoriatic arthropathy 49.70 9.85 35 51855 228300 90348257
Venous pressure jugular increased 49.68 9.85 17 51873 583 90575974
C-reactive protein abnormal 49.59 9.85 7 51883 127422 90449135
Tricuspid valve incompetence 48.98 9.85 54 51836 16677 90559880
Swollen joint count increased 48.64 9.85 4 51886 111202 90465355
Stevens-Johnson syndrome 48.10 9.85 71 51819 29305 90547252
Diverticulum 47.98 9.85 46 51844 12067 90564490
Bursitis 45.22 9.85 10 51880 131644 90444913
Gastrooesophageal reflux disease 44.48 9.85 201 51689 166136 90410421
Diarrhoea 44.35 9.85 769 51121 938421 89638136
Iron deficiency anaemia 42.86 9.85 60 51830 23602 90552955
Hysterectomy 42.16 9.85 42 51848 11542 90565015
Sleep disorder 40.97 9.85 32 51858 197998 90378559
Dyspnoea exertional 40.93 9.85 112 51778 72176 90504381
Thrombocytopenia 40.21 9.85 230 51660 208495 90368062
Product use issue 39.42 9.85 81 51809 329838 90246719
Facet joint syndrome 39.25 9.85 5 51885 98384 90478173
SARS-CoV-2 RNA increased 39.16 9.85 10 51880 119 90576438
Pulmonary embolism 38.72 9.85 163 51727 130657 90445900
Toxicity to various agents 38.50 9.85 66 51824 287780 90288777
Swelling 38.34 9.85 118 51772 418940 90157617
Ill-defined disorder 38.09 9.85 30 51860 184861 90391696
Neutropenic infection 37.32 9.85 19 51871 1790 90574767
Injury 37.03 9.85 35 51855 197314 90379243
Breast cancer stage III 37.03 9.85 3 51887 84444 90492113
Dehydration 36.62 9.85 213 51677 194234 90382323
Tonsillar haemorrhage 36.27 9.85 11 51879 254 90576303
Autonomic dysreflexia 36.16 9.85 12 51878 374 90576183
Lip dry 36.05 9.85 7 51883 100948 90475609
Hypercholesterolaemia 36.02 9.85 7 51883 100885 90475672
Rectal prolapse 36 9.85 20 51870 2247 90574310
Septic shock 35.92 9.85 118 51772 84042 90492515
Epilepsy 35.83 9.85 3 51887 82203 90494354
Transplant rejection 35.33 9.85 40 51850 12718 90563839
Odynophagia 35.17 9.85 34 51856 9009 90567548
Joint range of motion decreased 34.87 9.85 17 51873 135626 90440931
Oesophagitis 34.66 9.85 46 51844 17203 90559354
Parainfluenzae virus infection 34.61 9.85 21 51869 2782 90573775
Deep vein thrombosis 34.32 9.85 123 51767 91497 90485060
Live birth 34.17 9.85 3 51887 79104 90497453
Grip strength decreased 33.96 9.85 6 51884 92570 90483987
Skin infection 33.40 9.85 46 51844 17818 90558739
Drug abuse 33.30 9.85 4 51886 82343 90494214
Acute respiratory failure 33.29 9.85 75 51815 42843 90533714
Mobility decreased 33.06 9.85 58 51832 250676 90325881
Hypersensitivity 32.40 9.85 142 51748 454535 90122022
Anaemia 32.18 9.85 326 51564 352476 90224081
Cytomegalovirus infection 32.16 9.85 56 51834 26546 90550011
Female genital tract fistula 31.90 9.85 45 51845 17823 90558734
Pancytopenia 31.89 9.85 145 51745 120118 90456439
Polyomavirus-associated nephropathy 31.64 9.85 19 51871 2471 90574086
Oropharyngeal candidiasis 31.61 9.85 15 51875 1213 90575344
Failure to thrive 31.55 9.85 31 51859 8380 90568177
Cytokine release syndrome 31.39 9.85 57 51833 27916 90548641
Kyphosis 31.39 9.85 20 51870 2888 90573669
Chronic sinusitis 31.28 9.85 52 51838 23750 90552807
Red blood cell sedimentation rate increased 31.07 9.85 5 51885 82590 90493967
Dysphagia 31.00 9.85 137 51753 112141 90464416
Deep vein thrombosis postoperative 29.75 9.85 3 51887 70806 90505751
Peripheral venous disease 29.58 9.85 6 51884 83915 90492642
Sleep apnoea syndrome 28.66 9.85 59 51831 31688 90544869
Sepsis syndrome 28.51 9.85 13 51877 960 90575597
Lip swelling 28.32 9.85 66 51824 38544 90538013
Vulvovaginal candidiasis 28.30 9.85 21 51869 3879 90572678
Tumour pain 28.21 9.85 16 51874 1871 90574686
Blister 27.66 9.85 66 51824 254932 90321625
Lung neoplasm 27.48 9.85 26 51864 6709 90569848
Pleural effusion 27.47 9.85 132 51758 111859 90464698
Knee arthroplasty 27.22 9.85 7 51883 83175 90493382
Atrial fibrillation 26.88 9.85 149 51741 133462 90443095
Mouth ulceration 26.80 9.85 66 51824 39908 90536649
Neuropathy peripheral 26.40 9.85 151 51739 136819 90439738
Productive cough 25.97 9.85 100 51790 76963 90499594
Pain 25.97 9.85 408 51482 995933 89580624
Pseudomonas infection 25.89 9.85 37 51853 14828 90561729
Conjunctivitis 25.74 9.85 51 51839 26655 90549902
Prescribed overdose 25.45 9.85 12 51878 97613 90478944
Transfusion 25.42 9.85 40 51850 17448 90559109
Pulmonary fibrosis 25.40 9.85 15 51875 107488 90469069
Strongyloidiasis 25.08 9.85 14 51876 1588 90574969
Abscess neck 24.95 9.85 11 51879 750 90575807
Hydronephrosis 24.81 9.85 33 51857 12369 90564188
Myocardial calcification 24.65 9.85 8 51882 232 90576325
Complications of transplanted kidney 24.32 9.85 17 51873 2861 90573696
Autoimmune disorder 24.10 9.85 7 51883 76737 90499820
Gait inability 24.09 9.85 29 51861 146427 90430130
Bundle branch block left 24.04 9.85 26 51864 7859 90568698
Disease recurrence 24.02 9.85 61 51829 37592 90538965
Staphylococcal sepsis 23.60 9.85 28 51862 9355 90567202
Urosepsis 23.49 9.85 43 51847 21189 90555368
C-reactive protein increased 22.97 9.85 43 51847 181346 90395211
Pulmonary oedema 22.96 9.85 83 51807 61997 90514560
COVID-19 pneumonia 22.94 9.85 39 51851 18138 90558419
Intentional product use issue 22.84 9.85 57 51833 216835 90359722
Acute kidney injury 22.80 9.85 282 51608 320105 90256452
Epiglottic erythema 22.80 9.85 6 51884 81 90576476
Pneumonitis 22.62 9.85 66 51824 44104 90532453
Adjustment disorder with depressed mood 22.36 9.85 3 51887 56750 90519807
Hip arthroplasty 22.08 9.85 8 51882 76200 90500357
Cardiac failure congestive 21.85 9.85 113 51777 98581 90477976
Adverse event 21.81 9.85 21 51869 117397 90459160
Night sweats 21.71 9.85 25 51865 128741 90447816
Herpes simplex oesophagitis 21.70 9.85 7 51883 199 90576358
Blepharospasm 21.68 9.85 3 51887 55442 90521115
Lung transplant rejection 21.67 9.85 11 51879 1030 90575527
Gastrointestinal disorder 21.56 9.85 75 51815 256612 90319945
Blood culture positive 21.50 9.85 20 51870 5052 90571505
Nail disorder 21.29 9.85 4 51886 59063 90517494
Intentional overdose 20.91 9.85 14 51876 93820 90482737
Constipation 20.90 9.85 249 51641 280146 90296411
Otitis media 20.84 9.85 21 51869 5849 90570708
Polyglandular disorder 20.83 9.85 7 51883 227 90576330
Tongue ulceration 20.76 9.85 18 51872 4150 90572407
Aspergillus infection 20.43 9.85 28 51862 10795 90565762
Herpes simplex 20.22 9.85 27 51863 10154 90566403
Peripheral swelling 20.17 9.85 146 51744 412960 90163597
Oesophageal candidiasis 19.92 9.85 22 51868 6807 90569750
Haematemesis 19.83 9.85 53 51837 33673 90542884
Oral mucosal blistering 19.67 9.85 22 51868 6902 90569655
Hypophagia 19.66 9.85 55 51835 35882 90540675
Inflammation 19.54 9.85 46 51844 178546 90398011
Acute generalised exanthematous pustulosis 19.45 9.85 31 51859 13672 90562885
Ureteric obstruction 19.05 9.85 13 51877 2105 90574452
Liver disorder 18.92 9.85 25 51865 121244 90455313
Klebsiella bacteraemia 18.91 9.85 14 51876 2578 90573979
Fungal skin infection 18.89 9.85 19 51871 5282 90571275
Oral pain 18.86 9.85 51 51839 32632 90543925
Epiglottic oedema 18.66 9.85 6 51884 169 90576388
Urticaria 18.61 9.85 104 51786 312630 90263927
Mental status changes 18.48 9.85 62 51828 44617 90531940
Wheezing 18.44 9.85 213 51677 237867 90338690
Culture stool positive 18.39 9.85 7 51883 327 90576230
Prescribed underdose 18.39 9.85 10 51880 75009 90501548
Gastrointestinal viral infection 18.38 9.85 11 51879 1422 90575135
Anaemia folate deficiency 18.25 9.85 8 51882 538 90576019
Benign laryngeal neoplasm 18.09 9.85 4 51886 24 90576533
Leukopenia 18.09 9.85 109 51781 100601 90475956
Mucormycosis 18.03 9.85 16 51874 3805 90572752
Blood test abnormal 17.82 9.85 38 51852 20914 90555643
Clostridium difficile colitis 17.80 9.85 44 51846 26662 90549895
Tongue blistering 17.73 9.85 12 51878 1918 90574639
Hypoxia 17.51 9.85 85 51805 72314 90504243
Escherichia infection 17.34 9.85 32 51858 15863 90560694
Oropharyngeal pain 17.21 9.85 119 51771 115068 90461489
Visual impairment 17.09 9.85 31 51859 132334 90444223
Incorrect route of product administration 17.07 9.85 4 51886 50622 90525935
Oral disorder 16.93 9.85 25 51865 10320 90566237
Neutropenic sepsis 16.73 9.85 34 51856 18096 90558461
Endocrine disorder 16.71 9.85 9 51881 951 90575606
Autoimmune lung disease 16.63 9.85 5 51885 112 90576445
Myelosuppression 16.62 9.85 5 51885 53586 90522971
X-ray abnormal 16.53 9.85 3 51887 45421 90531136
Renal artery stenosis 16.42 9.85 12 51878 2165 90574392
Death 16.39 9.85 359 51531 456192 90120365
Drug hypersensitivity 16.39 9.85 178 51712 463431 90113126
Lupus vulgaris 16.35 9.85 3 51887 45056 90531501
Pharyngeal ulceration 16.27 9.85 9 51881 1003 90575554
Colitis 16.12 9.85 81 51809 69861 90506696
Lung disorder 16.08 9.85 39 51851 149844 90426713
Skin exfoliation 15.90 9.85 79 51811 67834 90508723
Hypervolaemia 15.87 9.85 48 51842 32709 90543848
Musculoskeletal pain 15.79 9.85 48 51842 171203 90405354
Nasopharyngitis 15.74 9.85 153 51737 406951 90169606
Sciatica 15.71 9.85 21 51869 101361 90475196
Confusional state 15.42 9.85 144 51746 386061 90190496
Lymphadenitis fungal 15.24 9.85 3 51887 9 90576548
Lethargy 15.18 9.85 74 51816 63065 90513492
Onychalgia 15.17 9.85 9 51881 1145 90575412
Atelectasis 15.01 9.85 39 51851 24370 90552187
Road traffic accident 15.01 9.85 24 51866 107602 90468955
Eczema 14.96 9.85 65 51825 52805 90523752
Heart transplant rejection 14.94 9.85 8 51882 836 90575721
Lower limb fracture 14.88 9.85 16 51874 84997 90491560
Kidney transplant rejection 14.78 9.85 16 51874 4841 90571716
Blood creatinine increased 14.71 9.85 104 51786 101282 90475275
Torticollis 14.71 9.85 12 51878 2546 90574011
Gastroenteritis radiation 14.71 9.85 7 51883 570 90575987
Abdominal pain upper 14.62 9.85 121 51769 332553 90244004
Wound infection 14.58 9.85 24 51866 106378 90470179
Plasmapheresis 14.55 9.85 6 51884 347 90576210
Pharyngotonsillitis 14.46 9.85 5 51885 177 90576380
Supraventricular tachycardia 14.32 9.85 30 51860 16306 90560251
Asthma 14.25 9.85 206 51684 241954 90334603
Chronic respiratory failure 13.98 9.85 12 51878 2729 90573828
Vitamin D deficiency 13.97 9.85 31 51859 17525 90559032
Mucosal toxicity 13.80 9.85 6 51884 396 90576161
Chest discomfort 13.63 9.85 130 51760 138235 90438322
Keratitis 13.62 9.85 14 51876 3992 90572565
Back injury 13.32 9.85 5 51885 46617 90529940
Abdominal sepsis 13.23 9.85 9 51881 1450 90575107
Foot deformity 13.16 9.85 9 51881 59642 90516915
Oral mucosa erosion 13.06 9.85 9 51881 1480 90575077
Onychomadesis 13.03 9.85 5 51885 45993 90530564
Therapeutic product effect incomplete 12.92 9.85 62 51828 193834 90382723
Pregnancy 12.86 9.85 10 51880 62037 90514520
Lupus-like syndrome 12.74 9.85 6 51884 48840 90527717
Respiratory tract infection viral 12.72 9.85 12 51878 3084 90573473
Chronic hepatitis 12.67 9.85 8 51882 1137 90575420
Nocardiosis 12.60 9.85 11 51879 2559 90573998
Tendon pain 12.57 9.85 13 51877 3735 90572822
Shock haemorrhagic 12.55 9.85 24 51866 12221 90564336
Oliguria 12.37 9.85 22 51868 10602 90565955
Upper-airway cough syndrome 12.35 9.85 27 51863 15108 90561449
Device expulsion 12.35 9.85 4 51886 40882 90535675
Nasal herpes 12.34 9.85 7 51883 819 90575738
Suicide attempt 12.32 9.85 15 51875 75384 90501173
Distal intestinal obstruction syndrome 12.29 9.85 6 51884 517 90576040
Abortion spontaneous 12.13 9.85 8 51882 54048 90522509
Aphthous ulcer 12.08 9.85 29 51861 17258 90559299
Bacteraemia 12.07 9.85 34 51856 22266 90554291
Anorexia nervosa 12.04 9.85 5 51885 294 90576263
Overdose 11.98 9.85 48 51842 157661 90418896
Arthralgia 11.94 9.85 347 51543 778175 89798382
Hypertensive emergency 11.91 9.85 10 51880 2207 90574350
Tracheitis 11.71 9.85 7 51883 903 90575654
Blister infected 11.69 9.85 7 51883 906 90575651
Obesity 11.68 9.85 27 51863 105480 90471077
Gastrointestinal haemorrhage 11.63 9.85 90 51800 90158 90486399
Drug reaction with eosinophilia and systemic symptoms 11.54 9.85 5 51885 42753 90533804
Therapy non-responder 11.43 9.85 40 51850 136664 90439893
Renal failure 11.42 9.85 120 51770 130887 90445670
Essential hypertension 11.41 9.85 16 51874 6299 90570258
Clostridium difficile infection 11.37 9.85 46 51844 36199 90540358
Genitourinary symptom 11.37 9.85 4 51886 149 90576408
Radiation pneumonitis 11.28 9.85 9 51881 1849 90574708
Aphonia 11.24 9.85 23 51867 12296 90564261
Weight increased 11.22 9.85 170 51720 417757 90158800
Xeroderma 11.20 9.85 5 51885 351 90576206
Anaemia of malignant disease 11.19 9.85 6 51884 628 90575929
Hypoparathyroidism 11.09 9.85 7 51883 994 90575563
Cheilitis 11.07 9.85 14 51876 4993 90571564
Staphylococcus test positive 10.99 9.85 13 51877 4332 90572225
Infection reactivation 10.94 9.85 9 51881 1931 90574626
Encephalopathy 10.85 9.85 54 51836 46390 90530167
Blood potassium decreased 10.81 9.85 55 51835 47672 90528885
Platelet count decreased 10.80 9.85 123 51767 136846 90439711
Haematocrit decreased 10.76 9.85 50 51840 41782 90534775
Enterococcal infection 10.76 9.85 20 51870 9971 90566586
Pancreatic failure 10.75 9.85 8 51882 1484 90575073
Viral rash 10.72 9.85 5 51885 389 90576168
Acute myeloid leukaemia 10.72 9.85 31 51859 20609 90555948
Onychomycosis 10.69 9.85 4 51886 37372 90539185
Hypoaesthesia 10.55 9.85 122 51768 314088 90262469
Oesophageal oedema 10.44 9.85 3 51887 57 90576500
Laryngeal oedema 10.37 9.85 16 51874 6865 90569692
Klebsiella infection 10.33 9.85 20 51870 10277 90566280
Finger deformity 10.33 9.85 3 51887 32894 90543663
Coma 10.31 9.85 16 51874 72616 90503941
Injection site erythema 10.27 9.85 26 51864 98476 90478081
Lower respiratory tract infection 10.19 9.85 93 51797 250566 90325991
Cytomegalovirus infection reactivation 10.19 9.85 17 51873 7783 90568774
Contraindicated product prescribed 10.16 9.85 8 51882 1614 90574943
Tonsillar hypertrophy 10.09 9.85 7 51883 1165 90575392
Gastritis 10.08 9.85 49 51841 41704 90534853
Sputum abnormal 10.06 9.85 6 51884 771 90575786
Coronavirus infection 10.01 9.85 14 51876 5501 90571056
Hospice care 9.92 9.85 19 51871 9685 90566872
Plasma cell myeloma 9.92 9.85 48 51842 40780 90535777
Carbon dioxide decreased 9.89 9.85 10 51880 2798 90573759
Product quality issue 9.87 9.85 19 51871 79306 90497251
Chemical burn of oral cavity 9.86 9.85 3 51887 70 90576487

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Febrile neutropenia 124.20 11.38 343 28992 185360 42406640
Oral candidiasis 101.25 11.38 82 29253 14323 42577677
Candida infection 88.80 11.38 91 29244 21519 42570481
Trichoglossia 84.30 11.38 24 29311 363 42591637
Transplant rejection 74.34 11.38 67 29268 13521 42578479
Pelvic mass 66.54 11.38 18 29317 223 42591777
Sepsis 58.74 11.38 282 29053 199052 42392948
Drug abuse 51.27 11.38 6 29329 104765 42487235
Completed suicide 51.22 11.38 4 29331 96461 42495539
Drug ineffective 50.00 11.38 244 29091 629953 41962047
Respiratory tract infection bacterial 49.97 11.38 25 29310 1884 42590116
Pericarditis fungal 48.62 11.38 14 29321 221 42591779
Blood electrolytes abnormal 47.44 11.38 20 29315 1014 42590986
Pyelonephritis fungal 45.45 11.38 11 29324 84 42591916
Gastritis fungal 44.86 11.38 12 29323 142 42591858
Urinary tract infection 44.60 11.38 160 29175 99124 42492876
Mucosal inflammation 43.08 11.38 101 29234 49273 42542727
Complications of transplanted kidney 43.07 11.38 33 29302 5317 42586683
Pyrexia 42.67 11.38 436 28899 393606 42198394
Blood urea abnormal 42.38 11.38 19 29316 1119 42590881
Neutropenia 42.33 11.38 258 29077 199173 42392827
Malignant transformation 41.83 11.38 18 29317 960 42591040
Pneumonia 41.47 11.38 458 28877 421691 42170309
Respiratory tract infection viral 41.34 11.38 27 29308 3379 42588621
Granulomatous dermatitis 40.28 11.38 13 29322 306 42591694
Prostate cancer recurrent 40.07 11.38 18 29317 1065 42590935
Fungal infection 39.84 11.38 58 29277 19664 42572336
Mouth ulceration 39.33 11.38 50 29285 14913 42577087
Kidney transplant rejection 38.29 11.38 38 29297 8645 42583355
Odynophagia 38.25 11.38 34 29301 6736 42585264
Dysphagia 37.74 11.38 123 29212 72596 42519404
Aplasia 37.08 11.38 29 29306 4814 42587186
New onset diabetes after transplantation 36.15 11.38 11 29324 212 42591788
Latent autoimmune diabetes in adults 35.58 11.38 10 29325 144 42591856
Thrombocytopenia 34.73 11.38 237 29098 190042 42401958
Toxicity to various agents 34.36 11.38 66 29269 229070 42362930
Chronic papillomatous dermatitis 33.54 11.38 8 29327 57 42591943
Pneumonia fungal 33.09 11.38 36 29299 9110 42582890
Dermatophytosis 32.83 11.38 11 29324 292 42591708
Meningitis fungal 32.47 11.38 10 29325 201 42591799
Fungal skin infection 32.27 11.38 23 29312 3318 42588682
Infection reactivation 30.63 11.38 19 29316 2175 42589825
Stomatitis 28.73 11.38 88 29247 50241 42541759
Hydronephrosis 28.61 11.38 38 29297 11827 42580173
American trypanosomiasis 27.34 11.38 10 29325 346 42591654
Cytomegalovirus infection 26.99 11.38 65 29270 32241 42559759
Trichophytosis 26.11 11.38 10 29325 394 42591606
Immunosuppressant drug level increased 25.50 11.38 29 29306 7702 42584298
Serum sickness 25.46 11.38 17 29318 2208 42589792
Disseminated trichosporonosis 25.22 11.38 7 29328 96 42591904
Urinary tract infection pseudomonal 25.19 11.38 14 29321 1307 42590693
Respiratory failure 24.80 11.38 162 29173 127970 42464030
Toxic epidermal necrolysis 24.73 11.38 56 29279 26694 42565306
Aspergillus infection 24.23 11.38 41 29294 15796 42576204
Cryptococcosis 24.09 11.38 19 29316 3192 42588808
Immune-mediated thyroiditis 24.06 11.38 10 29325 489 42591511
Klebsiella infection 23.87 11.38 34 29301 11298 42580702
Fungal peritonitis 23.63 11.38 12 29323 933 42591067
Focal segmental glomerulosclerosis 23.37 11.38 17 29318 2531 42589469
Intentional product misuse 22.98 11.38 7 29328 61893 42530107
Heart transplant 22.80 11.38 12 29323 1005 42590995
Facial paresis 21.78 11.38 18 29317 3232 42588768
Septic shock 21.60 11.38 122 29213 91550 42500450
Transposition of the great vessels 21.35 11.38 9 29326 456 42591544
Oral pain 21.14 11.38 34 29301 12562 42579438
Cerebral haemorrhage neonatal 21.06 11.38 8 29327 308 42591692
Enterobacter infection 20.89 11.38 17 29318 2987 42589013
Hepatic function abnormal 20.71 11.38 5 29330 51562 42540438
Leukopenia 20.70 11.38 104 29231 74642 42517358
Cryptococcal meningoencephalitis 20.31 11.38 7 29328 203 42591797
Glossodynia 19.86 11.38 19 29316 4133 42587867
Nocardiosis 19.78 11.38 21 29314 5169 42586831
Enterococcal infection 19.53 11.38 32 29303 12007 42579993
Morganella infection 18.88 11.38 9 29326 610 42591390
Corynebacterium infection 18.62 11.38 10 29325 873 42591127
Condition aggravated 18.28 11.38 105 29230 260649 42331351
Parainfluenzae virus infection 18.05 11.38 17 29318 3626 42588374
Loss of personal independence in daily activities 17.84 11.38 6 29329 49810 42542190
Inappropriate schedule of product administration 17.76 11.38 24 29311 95878 42496122
Human ehrlichiosis 17.39 11.38 8 29327 500 42591500
Dehydration 17.27 11.38 161 29174 141606 42450394
Neutrophilic dermatosis 17.16 11.38 7 29328 326 42591674
Acute respiratory failure 16.90 11.38 62 29273 38796 42553204
Pneumonia haemophilus 16.88 11.38 10 29325 1054 42590946
Hypervolaemia 16.67 11.38 44 29291 23081 42568919
Coma 16.65 11.38 8 29327 53546 42538454
Failure to thrive 16.60 11.38 26 29309 9396 42582604
Granuloma 16.56 11.38 17 29318 4024 42587976
Pulmonary nocardiosis 16.42 11.38 12 29323 1800 42590200
Oesophageal injury 16.26 11.38 6 29329 213 42591787
Interstitial lung disease 16.25 11.38 18 29317 78444 42513556
Overdose 16.03 11.38 30 29305 105234 42486766
Pulmonary resection 15.72 11.38 5 29330 112 42591888
Pharyngeal ulceration 15.57 11.38 7 29328 415 42591585
Pneumonia pseudomonal 15.49 11.38 18 29317 4891 42587109
Low cardiac output syndrome 15.47 11.38 8 29327 646 42591354
Clostridial infection 15.34 11.38 16 29319 3858 42588142
Oral viral infection 15.22 11.38 4 29331 44 42591956
BK virus infection 15.14 11.38 24 29311 8760 42583240
Enterovirus infection 15.08 11.38 10 29325 1283 42590717
Liver transplant rejection 14.95 11.38 13 29322 2500 42589500
Hepatic artery thrombosis 14.95 11.38 6 29329 268 42591732
Cytomegalovirus viraemia 14.74 11.38 26 29309 10351 42581649
Injection site pain 14.65 11.38 11 29324 57787 42534213
Mucosal disorder 14.48 11.38 12 29323 2162 42589838
Anaemia 14.47 11.38 272 29063 280006 42311994
Mucormycosis 14.41 11.38 21 29314 7122 42584878
Choriomeningitis lymphocytic 14.34 11.38 5 29330 150 42591850
Rhinovirus infection 14.31 11.38 20 29315 6528 42585472
Haemolytic anaemia 14.24 11.38 28 29307 12099 42579901
Respiratory tract infection 14.07 11.38 45 29290 26277 42565723
Documented hypersensitivity to administered product 14.01 11.38 6 29329 316 42591684
Electrocardiogram ST segment depression 14.00 11.38 13 29322 2724 42589276
Jarisch-Herxheimer reaction 13.93 11.38 8 29327 795 42591205
Therapeutic product effect incomplete 13.91 11.38 17 29318 70922 42521078
Stevens-Johnson syndrome 13.81 11.38 40 29295 22138 42569862
Tumour flare 13.65 11.38 9 29326 1144 42590856
Disseminated cryptococcosis 13.61 11.38 11 29324 1914 42590086
Polyomavirus-associated nephropathy 13.56 11.38 18 29317 5597 42586403
Intraventricular haemorrhage 13.55 11.38 15 29320 3869 42588131
Postoperative wound infection 13.49 11.38 18 29317 5624 42586376
Blood creatinine increased 13.43 11.38 125 29210 109878 42482122
IVth nerve paralysis 13.33 11.38 7 29328 584 42591416
Stress 13.15 11.38 7 29328 44205 42547795
Post transplant lymphoproliferative disorder 13.15 11.38 23 29312 9097 42582903
Drug intolerance 13.07 11.38 22 29313 80402 42511598
Pneumonitis 12.95 11.38 60 29275 41658 42550342
Neutrophil morphology abnormal 12.87 11.38 4 29331 83 42591917
Cutaneous mucormycosis 12.75 11.38 7 29328 638 42591362
Mental status changes 12.65 11.38 60 29275 42055 42549945
Myelosuppression 12.65 11.38 6 29329 40455 42551545
Cellulitis 12.60 11.38 79 29256 61506 42530494
Right ventricular systolic pressure increased 12.57 11.38 6 29329 408 42591592
Brain herniation 12.49 11.38 16 29319 4807 42587193
Diarrhoea 12.31 11.38 409 28926 460440 42131560
Drug interaction 12.27 11.38 121 29214 266878 42325122
Oesophageal ulcer 12.23 11.38 14 29321 3745 42588255
Meningitis cryptococcal 12.01 11.38 13 29322 3270 42588730
Restrictive cardiomyopathy 11.77 11.38 7 29328 743 42591257
Staphylococcal infection 11.58 11.38 54 29281 37589 42554411
Pseudomonal bacteraemia 11.53 11.38 11 29324 2385 42589615

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Schizophrenia 402.68 9.98 219 68970 21607 110498503
Hypomania 355.45 9.98 158 69031 10052 110510058
Febrile neutropenia 338.60 9.98 664 68525 316103 110204007
Jaundice cholestatic 310.19 9.98 161 69028 14447 110505663
Candida infection 240.43 9.98 216 68973 47793 110472317
Cholelithiasis 237.35 9.98 243 68946 63179 110456931
Nasal polyps 222.99 9.98 125 69064 13075 110507035
Pneumonia 222.55 9.98 1109 68080 875605 109644505
Total lung capacity increased 200.34 9.98 86 69103 5026 110515084
Asthma-chronic obstructive pulmonary disease overlap syndrome 185.62 9.98 87 69102 6257 110513853
Oral candidiasis 177.52 9.98 177 69012 44583 110475527
Blood bilirubin increased 174.13 9.98 226 68963 75746 110444364
Sepsis 163.55 9.98 513 68676 326833 110193277
Drug ineffective 143.21 9.98 482 68707 1520058 109000052
Sarcoidosis 142.13 9.98 92 69097 12487 110507623
Psychotic disorder 136.67 9.98 164 69025 50773 110469337
Hepatotoxicity 126.04 9.98 176 69013 63224 110456886
Rhinitis allergic 121.41 9.98 96 69093 17826 110502284
Hand deformity 118.71 9.98 4 69185 218502 110301608
Contraindicated product administered 112.75 9.98 12 69177 248255 110271855
Completed suicide 111.93 9.98 11 69178 242370 110277740
Pericarditis 109.39 9.98 7 69182 219107 110301003
Systemic lupus erythematosus 108.85 9.98 15 69174 254323 110265787
Fungal infection 108.47 9.98 146 69043 50660 110469450
Mucosal inflammation 107.90 9.98 206 68983 95935 110424175
Synovitis 106.55 9.98 21 69168 274071 110246039
Salpingo-oophorectomy unilateral 100.36 9.98 32 69157 799 110519311
Urinary tract infection 99.39 9.98 436 68753 325846 110194264
Arthropathy 98.12 9.98 29 69160 287493 110232617
Sinusitis fungal 97.59 9.98 43 69146 2677 110517433
Maternal exposure during pregnancy 96.03 9.98 21 69168 254862 110265248
Neutropenia 95.33 9.98 475 68714 374145 110145965
Helicobacter infection 93.25 9.98 5 69184 181872 110338238
Drug intolerance 90.45 9.98 73 69116 406439 110113671
Therapeutic product effect decreased 90.30 9.98 21 69168 244295 110275815
Rheumatoid arthritis 88.97 9.98 38 69151 299575 110220535
Duodenal ulcer perforation 87.74 9.98 6 69183 177694 110342416
Sputum increased 85.20 9.98 50 69139 5701 110514409
Pemphigus 84.31 9.98 16 69173 214554 110305556
Toxic epidermal necrolysis 83.61 9.98 137 69052 56590 110463520
Transplant rejection 80.96 9.98 88 69101 24479 110495631
Drug abuse 79.46 9.98 9 69180 177402 110342708
Cardiac murmur 79.04 9.98 87 69102 24541 110495569
Chronic obstructive pulmonary disease 76.95 9.98 194 68995 108964 110411146
Hiatus hernia 75.88 9.98 90 69099 27516 110492594
Muscle injury 75.01 9.98 3 69186 140804 110379306
Odynophagia 73.66 9.98 65 69124 14036 110506074
Treatment failure 70.60 9.98 43 69146 277191 110242919
Complications of transplanted kidney 68.66 9.98 48 69141 7394 110512716
Thrombocytopenia 68.28 9.98 412 68777 348473 110171637
Wound 67.59 9.98 31 69158 234406 110285704
Trichoglossia 67.15 9.98 24 69165 856 110519254
Toxicity to various agents 67.06 9.98 124 69065 480431 110039679
Rheumatoid factor positive 66.30 9.98 4 69185 131636 110388474
Dysphagia 65.21 9.98 228 68961 153372 110366738
Embolism venous 64.91 9.98 40 69149 4983 110515127
Bronchiectasis 64.75 9.98 96 69093 36397 110483713
Respiratory failure 62.68 9.98 284 68905 215048 110305062
C-reactive protein abnormal 62.25 9.98 5 69184 129690 110390420
Infusion related reaction 61.91 9.98 89 69100 381073 110139037
Rheumatic fever 60.92 9.98 4 69185 122575 110397535
Septic shock 60.23 9.98 226 68963 157302 110362808
Joint swelling 59.39 9.98 117 69072 442728 110077382
Stevens-Johnson syndrome 58.25 9.98 105 69084 46796 110473314
Oedema peripheral 57.98 9.98 378 68811 328282 110191828
Vomiting 57.95 9.98 844 68345 909831 109610279
BK virus infection 57.89 9.98 55 69134 13051 110507059
Mouth ulceration 57.54 9.98 106 69083 48032 110472078
Respiratory tract infection viral 56.78 9.98 39 69150 5839 110514271
Abdominal discomfort 56.38 9.98 100 69089 393758 110126352
Cellulitis 56.05 9.98 190 68999 125826 110394284
Lung neoplasm malignant 55.74 9.98 86 69103 33756 110486354
Musculoskeletal stiffness 55.34 9.98 56 69133 279766 110240344
Fibromyalgia 55.16 9.98 19 69170 170890 110349220
Exposure during pregnancy 55.10 9.98 18 69171 167406 110352704
Folliculitis 53.48 9.98 19 69170 167634 110352476
General physical health deterioration 53.11 9.98 117 69072 425178 110094932
Bursitis 52.51 9.98 9 69180 129909 110390201
Kidney transplant rejection 52.37 9.98 50 69139 11937 110508173
Intentional overdose 51.79 9.98 10 69179 132491 110387619
Psoriatic arthropathy 50.81 9.98 30 69159 196731 110323379
Irritable bowel syndrome 50.06 9.98 20 69169 164195 110355915
Pelvic mass 49.07 9.98 22 69167 1427 110518683
Parainfluenzae virus infection 48.62 9.98 38 69151 6936 110513174
Cytomegalovirus infection 48.44 9.98 106 69083 54338 110465772
Discomfort 48.41 9.98 38 69151 214669 110305441
Sleep disorder due to general medical condition, insomnia type 48.21 9.98 5 69184 105638 110414472
Impaired healing 48.03 9.98 32 69157 196685 110323425
Diastolic dysfunction 47.24 9.98 48 69141 12356 110507754
Glossodynia 46.73 9.98 42 69147 221962 110298148
Respiratory tract infection bacterial 46.66 9.98 25 69164 2391 110517719
Hydronephrosis 46.58 9.98 61 69128 20604 110499506
Blood cholesterol increased 46.56 9.98 29 69160 184756 110335354
Acute respiratory failure 46.14 9.98 127 69062 75133 110444977
Pericarditis fungal 45.93 9.98 14 69175 300 110519810
Aspergillus infection 44.89 9.98 67 69122 25549 110494561
Type 2 diabetes mellitus 44.40 9.98 28 69161 177204 110342906
Cough 44.07 9.98 462 68727 461179 110058931
Prostate cancer recurrent 43.77 9.98 18 69171 944 110519166
Neutrophilic dermatosis 43.60 9.98 17 69172 775 110519335
Autonomic dysreflexia 43.40 9.98 15 69174 484 110519626
Nausea 43.26 9.98 1044 68145 1234646 109285464
Facet joint syndrome 43.13 9.98 5 69184 96823 110423287
Fungal skin infection 43.12 9.98 36 69153 7213 110512897
Ill-defined disorder 41.81 9.98 23 69166 156830 110363280
Liver injury 41.65 9.98 21 69168 150392 110369718
Infection reactivation 41.61 9.98 28 69161 4053 110516057
Lip dry 40.30 9.98 7 69182 100076 110420034
Alopecia 40.27 9.98 107 69082 364646 110155464
Leukopenia 40.16 9.98 192 68997 148599 110371511
Tricuspid valve incompetence 39.79 9.98 61 69128 23812 110496298
Dehydration 39.10 9.98 304 68885 279207 110240903
Pneumonitis 39.10 9.98 121 69068 76410 110443700
Blood electrolytes abnormal 38.45 9.98 21 69168 2087 110518023
Diverticulum 38.41 9.98 48 69141 15478 110504632
Breast cancer stage III 38.10 9.98 3 69186 79114 110440996
Swollen joint count increased 38.07 9.98 4 69185 83657 110436453
Emphysema 38.00 9.98 54 69135 19702 110500408
Hysterectomy 37.66 9.98 35 69154 8079 110512031
Polyomavirus-associated nephropathy 37.34 9.98 35 69154 8166 110511944
Gastritis fungal 36.96 9.98 12 69177 318 110519792
Lung disorder 36.78 9.98 35 69154 180012 110340098
Injury 36.75 9.98 34 69155 177231 110342879
Malignant transformation 35.83 9.98 18 69171 1507 110518603
Oral pain 35.72 9.98 75 69114 37369 110482741
Sleep disorder 35.69 9.98 43 69146 198601 110321509
Joint range of motion decreased 35.27 9.98 16 69173 121816 110398294
Mobility decreased 35.12 9.98 59 69130 237363 110282747
Granulomatous dermatitis 35.12 9.98 13 69176 513 110519597
Pulmonary embolism 34.98 9.98 242 68947 214232 110305878
Blood urea abnormal 34.91 9.98 19 69170 1875 110518235
Venous pressure jugular increased 34.86 9.98 17 69172 1335 110518775
Latent autoimmune diabetes in adults 34.71 9.98 10 69179 175 110519935
Diarrhoea 34.63 9.98 945 68244 1138560 109381550
Pain 34.10 9.98 408 68781 954547 109565563
SARS-CoV-2 RNA increased 34.04 9.98 10 69179 188 110519922
Hypersensitivity 33.82 9.98 134 69055 403864 110116246
Respiratory symptom 33.51 9.98 44 69145 14901 110505209
Klebsiella infection 33.17 9.98 51 69138 19958 110500152
Mucormycosis 33.16 9.98 37 69152 10591 110509519
Pyelonephritis fungal 33.07 9.98 11 69178 315 110519795
Live birth 32.46 9.98 3 69186 69481 110450629
Pharyngeal ulceration 32.01 9.98 16 69173 1325 110518785
Chronic papillomatous dermatitis 31.80 9.98 8 69181 81 110520029
Gastrooesophageal reflux disease 31.70 9.98 207 68982 179769 110340341
Peripheral venous disease 31.52 9.98 7 69182 84110 110436000
Oropharyngeal candidiasis 31.03 9.98 18 69171 2008 110518102
Suicide attempt 30.85 9.98 13 69176 103381 110416729
Serum sickness 30.70 9.98 24 69165 4382 110515728
New onset diabetes after transplantation 30.32 9.98 11 69178 410 110519700
Female genital tract fistula 30.08 9.98 44 69145 16475 110503635
Anaemia 29.70 9.98 494 68695 546592 109973518
Grip strength decreased 29.39 9.98 7 69182 80167 110439943
Pneumonia fungal 29.37 9.98 41 69148 14713 110505397
Pancytopenia 29.31 9.98 228 68961 209385 110310725
Pyrexia 29.28 9.98 752 68437 897513 109622597
Epilepsy 29.26 9.98 13 69176 100196 110419914
Failure to thrive 28.95 9.98 39 69150 13535 110506575
Hypervolaemia 28.88 9.98 82 69107 49378 110470732
Meningitis fungal 28.75 9.98 10 69179 329 110519781
Immunosuppressant drug level increased 28.61 9.98 36 69153 11688 110508422
Heart transplant rejection 28.44 9.98 17 69172 2004 110518106
Therapeutic product effect incomplete 28.38 9.98 61 69128 223744 110296366
Product use issue 28.29 9.98 100 69089 311595 110208515
Kyphosis 28.11 9.98 20 69169 3167 110516943
Oral disorder 27.94 9.98 36 69153 11967 110508143
Transfusion 27.85 9.98 54 69135 25418 110494692
Overdose 27.79 9.98 66 69123 233728 110286382
Gastrointestinal disorder 27.43 9.98 70 69119 241882 110278228
Aplasia 27.34 9.98 29 69160 7844 110512266
Rectal prolapse 27.13 9.98 18 69171 2545 110517565
Cytokine release syndrome 26.97 9.98 101 69088 70205 110449905
Intentional product misuse 26.95 9.98 26 69163 132878 110387232
Dermatophytosis 26.89 9.98 11 69178 569 110519541
Pseudomonas infection 26.81 9.98 56 69133 27797 110492313
Nocardiosis 26.76 9.98 28 69161 7458 110512652
Lung neoplasm 26.73 9.98 29 69160 8047 110512063
Deep vein thrombosis postoperative 26.56 9.98 3 69186 59288 110460822
Atrial fibrillation 26.37 9.98 239 68950 229403 110290707
Myelosuppression 26.37 9.98 13 69176 94327 110425783
Pleural effusion 26.36 9.98 196 68993 177513 110342597
Granuloma 26.18 9.98 31 69158 9459 110510651
Swelling 25.97 9.98 122 69067 350919 110169191
Blood creatinine increased 25.60 9.98 199 68990 182690 110337420
Neutropenic infection 25.52 9.98 19 69170 3226 110516884
Iron deficiency anaemia 25.34 9.98 59 69130 31500 110488610
Vulvovaginal candidiasis 25.31 9.98 19 69170 3266 110516844
Trichophytosis 25.28 9.98 10 69179 474 110519636
Coma 25.15 9.98 22 69167 117847 110402263
Night sweats 25.15 9.98 28 69161 133955 110386155
Gait inability 25.05 9.98 29 69160 136347 110383763
Tumour pain 24.75 9.98 18 69171 2949 110517161
Hypercholesterolaemia 24.67 9.98 13 69176 90824 110429286
Sleep apnoea syndrome 24.54 9.98 68 69121 40379 110479731
Oesophagitis 24.51 9.98 55 69134 28660 110491450
Mucosal disorder 24.36 9.98 21 69168 4396 110515714
Strongyloidiasis 24.10 9.98 22 69167 4964 110515146
Hepatic function abnormal 23.93 9.98 13 69176 89282 110430828
Heart transplant 23.71 9.98 14 69175 1614 110518496
Corynebacterium infection 23.51 9.98 15 69174 1985 110518125
Cryptococcosis 23.50 9.98 21 69168 4610 110515500
Acanthosis 23.49 9.98 10 69179 572 110519538
Hypoxia 23.44 9.98 150 69039 129365 110390745
Medication error 23.30 9.98 19 69170 105347 110414763
Enterococcal infection 23.28 9.98 44 69145 20322 110499788
Liver disorder 23.28 9.98 33 69156 142210 110377900
Myocardial calcification 23.15 9.98 8 69181 258 110519852
Red blood cell sedimentation rate increased 23.11 9.98 10 69179 78292 110441818
Road traffic accident 22.97 9.98 20 69169 107378 110412732
Drug hypersensitivity 22.96 9.98 178 69011 453912 110066198
Tongue ulceration 22.77 9.98 21 69168 4801 110515309
Obstructive airways disorder 22.68 9.98 72 69117 46077 110474033
American trypanosomiasis 22.67 9.98 10 69179 624 110519486
Nasopharyngitis 22.65 9.98 149 69040 394212 110125898
Blood culture positive 22.61 9.98 28 69161 8948 110511162
Klebsiella bacteraemia 22.59 9.98 21 69168 4848 110515262
Mental status changes 22.57 9.98 101 69088 76021 110444089
Chronic sinusitis 22.49 9.98 49 69140 25035 110495075
Tonsillar haemorrhage 22.26 9.98 8 69181 290 110519820
Epiglottic erythema 22.14 9.98 6 69183 83 110520027
Obesity 22.04 9.98 23 69166 113328 110406782
Anaemia folate deficiency 21.71 9.98 10 69179 691 110519419
Skin infection 21.37 9.98 45 69144 22464 110497646
Sepsis syndrome 21.36 9.98 13 69176 1583 110518527
Nail disorder 21.35 9.98 5 69184 57930 110462180
Extravasation blood 21.33 9.98 9 69180 504 110519606
Lip swelling 21.30 9.98 75 69114 50592 110469518
Sciatica 21.27 9.98 16 69173 92383 110427727
Neutropenic sepsis 20.98 9.98 54 69135 30692 110489418
Fungal peritonitis 20.90 9.98 12 69177 1313 110518797
Intentional product use issue 20.88 9.98 82 69107 247824 110272286
Musculoskeletal pain 20.71 9.98 53 69136 182970 110337140
Pulmonary fibrosis 20.64 9.98 20 69169 102022 110418088
Abscess neck 20.54 9.98 12 69177 1356 110518754
Hypoaesthesia 20.52 9.98 114 69075 314109 110206001
Chronic respiratory failure 20.40 9.98 18 69171 3885 110516225
Dyspnoea exertional 20.38 9.98 123 69066 103937 110416173
Disseminated trichosporonosis 20.31 9.98 7 69182 224 110519886
Adverse event 20.13 9.98 23 69166 108786 110411324
Haemolytic anaemia 20.06 9.98 42 69147 20878 110499232
Headache 19.93 9.98 411 68778 881966 109638144
Blister 19.93 9.98 74 69115 227302 110292808
Polyglandular disorder 19.88 9.98 7 69182 239 110519871
Clostridial infection 19.77 9.98 22 69167 6280 110513830
Pneumonia pseudomonal 19.75 9.98 24 69165 7522 110512588
Urinary tract infection pseudomonal 19.73 9.98 14 69175 2208 110517902
Urticaria 19.58 9.98 118 69071 318739 110201371
Respiratory distress 19.39 9.98 90 69099 68784 110451326
Peripheral swelling 19.21 9.98 161 69028 403873 110116237
Bone erosion 19.21 9.98 3 69186 46368 110473742
Jarisch-Herxheimer reaction 19.14 9.98 11 69178 1206 110518904
Colitis 18.82 9.98 119 69070 102204 110417906
Oral mucosal blistering 18.79 9.98 24 69165 7910 110512200
Conjunctivitis 18.74 9.98 55 69134 33737 110486373
Staphylococcal infection 18.67 9.98 90 69099 69854 110450256
Rhabdomyolysis 18.66 9.98 29 69160 120372 110399738
Encephalopathy 18.63 9.98 100 69089 80955 110439155
Gastrointestinal viral infection 18.09 9.98 12 69177 1697 110518413
Knee arthroplasty 18.08 9.98 9 69180 64939 110455171
Tracheitis 18.01 9.98 12 69177 1709 110518401
Hepatic cytolysis 17.96 9.98 6 69183 55047 110465063
Lethargy 17.94 9.98 110 69079 93466 110426644
Benign laryngeal neoplasm 17.74 9.98 4 69185 24 110520086
Dizziness 17.65 9.98 319 68870 697874 109822236
Ureteric obstruction 17.57 9.98 15 69174 3099 110517011
Abdominal pain upper 17.57 9.98 137 69052 348974 110171136
Coeliac disease 17.43 9.98 3 69186 43184 110476926
Deep vein thrombosis 17.30 9.98 148 69041 139739 110380371
Hypophagia 17.27 9.98 72 69117 52554 110467556
Oesophageal candidiasis 17.18 9.98 28 69161 11506 110508604
Documented hypersensitivity to administered product 17.17 9.98 10 69179 1124 110518986
Urosepsis 17.08 9.98 50 69139 30625 110489485
Enterovirus infection 16.98 9.98 14 69175 2756 110517354
Lung transplant rejection 16.76 9.98 12 69177 1919 110518191
Cryptococcal meningoencephalitis 16.74 9.98 7 69182 383 110519727
Visual impairment 16.74 9.98 37 69152 134391 110385719
Rhinovirus infection 16.73 9.98 28 69161 11761 110508349
Tongue blistering 16.73 9.98 12 69177 1925 110518185
Aphthous ulcer 16.41 9.98 39 69150 21097 110499013
Lymphadenopathy 16.23 9.98 81 69108 63754 110456356
Blood potassium decreased 16.19 9.98 72 69117 54042 110466068
Enterobacter infection 16.06 9.98 19 69170 5792 110514318
Interstitial lung disease 16.03 9.98 40 69149 139294 110380816
Epiglottic oedema 15.84 9.98 7 69182 439 110519671
Focal segmental glomerulosclerosis 15.71 9.98 16 69173 4129 110515981
Prescribed overdose 15.68 9.98 19 69170 87562 110432548
Herpes simplex oesophagitis 15.57 9.98 7 69182 457 110519653
Staphylococcal sepsis 15.54 9.98 34 69155 17420 110502690
Human ehrlichiosis 15.52 9.98 8 69181 707 110519403
Bacteraemia 15.51 9.98 60 69129 42330 110477780
Autoimmune disorder 15.51 9.98 11 69178 65472 110454638
Disseminated cryptococcosis 15.40 9.98 13 69176 2644 110517466
Bronchopulmonary dysplasia 15.38 9.98 6 69183 274 110519836
Renal artery stenosis 15.26 9.98 15 69174 3711 110516399
Hip arthroplasty 15.14 9.98 8 69181 55805 110464305
Restrictive cardiomyopathy 15.13 9.98 9 69180 1052 110519058
Blood pressure systolic increased 14.86 9.98 18 69171 82973 110437137
Immune-mediated thyroiditis 14.86 9.98 9 69180 1087 110519023
Arthralgia 14.80 9.98 373 68816 779259 109740851
Oesophageal injury 14.73 9.98 6 69183 307 110519803
Bradycardia 14.70 9.98 49 69140 155468 110364642
Onychalgia 14.55 9.98 9 69180 1128 110518982
Oesophageal oedema 14.40 9.98 4 69185 61 110520049
Wheezing 14.38 9.98 232 68957 254998 110265112
Inflammation 14.37 9.98 67 69122 193171 110326939
Loss of personal independence in daily activities 14.37 9.98 47 69142 149973 110370137
Injection site reaction 14.24 9.98 21 69168 89049 110431061
Tumour flare 14.21 9.98 10 69179 1557 110518553
Skin oedema 14.17 9.98 11 69178 1988 110518122
Back injury 14.07 9.98 6 69183 47393 110472717
Carbon dioxide decreased 13.98 9.98 16 69173 4708 110515402
Adjustment disorder with depressed mood 13.94 9.98 5 69184 43878 110476232
Choriomeningitis lymphocytic 13.92 9.98 5 69184 181 110519929
Meningitis cryptococcal 13.88 9.98 16 69173 4746 110515364
Small intestinal obstruction 13.81 9.98 48 69141 32165 110487945
Blister infected 13.81 9.98 9 69180 1235 110518875
C-reactive protein increased 13.71 9.98 80 69109 217839 110302271
Intraventricular haemorrhage 13.58 9.98 17 69172 5490 110514620
Pulmonary resection 13.57 9.98 5 69184 195 110519915
Pulmonary nocardiosis 13.49 9.98 12 69177 2617 110517493
Viral skin infection 13.47 9.98 5 69184 199 110519911
Postoperative wound infection 13.25 9.98 30 69159 15723 110504387
Pulmonary oedema 13.24 9.98 108 69081 100551 110419559
IVth nerve paralysis 13.24 9.98 7 69182 652 110519458
Platelet count decreased 13.18 9.98 210 68979 230233 110289877
Culture stool positive 13.05 9.98 7 69182 671 110519439
Morganella infection 12.97 9.98 9 69180 1370 110518740
Dermatitis diaper 12.95 9.98 6 69183 420 110519690
Autoimmune lung disease 12.95 9.98 5 69184 222 110519888
Graft versus host disease 12.80 9.98 33 69156 18773 110501337
Paraesthesia 12.77 9.98 111 69078 276410 110243700
Acute kidney injury 12.74 9.98 502 68687 634928 109885182
X-ray abnormal 12.71 9.98 4 69185 38113 110481997
Oropharyngeal pain 12.69 9.98 135 69054 135141 110384969
Atelectasis 12.66 9.98 51 69138 36661 110483449
Urine output decreased 12.64 9.98 34 69155 19842 110500268
Productive cough 12.62 9.98 118 69071 114187 110405923
Cutaneous mucormycosis 12.56 9.98 7 69182 723 110519387
Right ventricular systolic pressure increased 12.52 9.98 8 69181 1061 110519049
Bundle branch block left 12.51 9.98 26 69163 12862 110507248
Injection site erythema 12.50 9.98 25 69164 94151 110425959
Incorrect route of product administration 12.45 9.98 13 69176 64048 110456062
Respiratory tract infection 12.38 9.98 82 69107 71535 110448575
Lupus vulgaris 12.34 9.98 3 69186 33880 110486230
Nasal herpes 12.28 9.98 7 69182 756 110519354
Low cardiac output syndrome 12.27 9.98 8 69181 1098 110519012
Laryngeal oedema 12.23 9.98 22 69167 9785 110510325
Klebsiella test positive 12.23 9.98 11 69178 2435 110517675
Facial paresis 12.19 9.98 17 69172 6096 110514014
Clostridium difficile colitis 12.17 9.98 57 69132 43721 110476389
Gastritis 12.17 9.98 66 69123 53633 110466477
Endocrine disorder 12.16 9.98 8 69181 1116 110518994
Herpes simplex 12.14 9.98 29 69160 15735 110504375
Hypoparathyroidism 12.13 9.98 9 69180 1521 110518589
Staphylococcal bacteraemia 12.11 9.98 30 69159 16658 110503452
Aplastic anaemia 12.01 9.98 38 69151 24270 110495840
Injection site pain 11.91 9.98 64 69125 177858 110342252
Gastroenteritis radiation 11.90 9.98 7 69182 801 110519309
Delayed graft function 11.90 9.98 14 69175 4243 110515867
Blood test abnormal 11.77 9.98 42 69147 28512 110491598
Anaphylactic shock 11.77 9.98 9 69180 51537 110468573
Acute generalised exanthematous pustulosis 11.76 9.98 35 69154 21629 110498481
Foot deformity 11.67 9.98 8 69181 48472 110471638
Escherichia bacteraemia 11.67 9.98 22 69167 10142 110509968
Cheilitis 11.66 9.98 17 69172 6348 110513762
Neutrophil morphology abnormal 11.63 9.98 4 69185 127 110519983
Pseudomonal bacteraemia 11.60 9.98 14 69175 4357 110515753
Pregnancy 11.55 9.98 9 69180 51058 110469052
Lymphadenitis fungal 11.46 9.98 3 69186 36 110520074
Anorexia nervosa 11.43 9.98 5 69184 306 110519804
Torticollis 11.43 9.98 12 69177 3209 110516901
Device related infection 11.39 9.98 52 69137 39467 110480643
Pharyngotonsillitis 11.34 9.98 5 69184 312 110519798
Post transplant lymphoproliferative disorder 11.26 9.98 28 69161 15585 110504525
Oral viral infection 11.24 9.98 4 69185 141 110519969
Liver transplant rejection 11.14 9.98 13 69176 3905 110516205
Diabetic ketoacidosis 11.14 9.98 54 69135 42004 110478106
Petechiae 11.11 9.98 36 69153 23281 110496829
Off label use 11.08 9.98 799 68390 1499386 109020724
Supraventricular tachycardia 11.01 9.98 37 69152 24385 110495725
Upper-airway cough syndrome 10.98 9.98 28 69161 15829 110504281
Chronic hepatitis 10.96 9.98 9 69180 1763 110518347
Otitis media 10.94 9.98 18 69171 7458 110512652
Cytomegalovirus viraemia 10.91 9.98 30 69159 17734 110502376
Lower limb fracture 10.88 9.98 19 69170 75329 110444781
Altered state of consciousness 10.86 9.98 12 69177 57614 110462496
Lupus-like syndrome 10.84 9.98 6 69183 40786 110479324
Blood albumin decreased 10.83 9.98 40 69149 27612 110492498
Chest wall abscess 10.82 9.98 5 69184 348 110519762
Fungaemia 10.78 9.98 16 69173 6070 110514040
Cardiac failure congestive 10.77 9.98 143 69046 150857 110369253
Blood pressure fluctuation 10.69 9.98 19 69170 74805 110445305
Pulmonary congestion 10.66 9.98 43 69146 30923 110489187
Drug-induced liver injury 10.56 9.98 39 69150 120028 110400082
Haematemesis 10.41 9.98 68 69121 59040 110461070
Empyema 10.38 9.98 15 69174 5555 110514555
Burning mouth syndrome 10.30 9.98 6 69183 675 110519435
Oral mucosa erosion 10.30 9.98 10 69179 2438 110517672
Escherichia sepsis 10.29 9.98 21 69168 10251 110509859
Migraine 10.28 9.98 64 69125 171588 110348522
Hepatic artery thrombosis 10.27 9.98 5 69184 391 110519719
Adverse drug reaction 10.16 9.98 33 69156 105526 110414584
Acute myeloid leukaemia 10.14 9.98 49 69140 38061 110482049
Infective pulmonary exacerbation of cystic fibrosis 10.14 9.98 26 69163 14745 110505365
Wound infection 10.11 9.98 29 69160 96436 110423674
Oesophageal ulcer 10.10 9.98 18 69171 7946 110512164
Flat affect 10.10 9.98 10 69179 2495 110517615
Mucosal toxicity 10.10 9.98 6 69183 700 110519410
Adverse reaction 10.06 9.98 3 69186 29591 110490519
Systemic inflammatory response syndrome 10.05 9.98 24 69165 13019 110507091
Oliguria 9.99 9.98 30 69159 18627 110501483

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sepsis neonatal 119.50 68.93 24 41 108 113780

Pharmacologic Action:

SourceCodeDescription
ATC A07AA02 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFECTIVES
Antibiotics
ATC D01AA01 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Antibiotics
ATC G01AA01 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Antibiotics
ATC G01AA51 GENITO URINARY SYSTEM AND SEX HORMONES
GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
Antibiotics
ATC J01RA19 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
COMBINATIONS OF ANTIBACTERIALS
Combinations of antibacterials
FDA CS M0017172 Polyenes
FDA EPC N0000175498 Polyene Antifungal
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000935 Antifungal Agents
MeSH PA D007476 Ionophores
MeSH PA D049990 Membrane Transport Modulators
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:66981 ophthalmology drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:76969 bacterial metabolite
CHEBI has role CHEBI:86327 antifungal drug
CHEBI has role CHEBI:231911 renoprotective agent

Related Drugs by ATC class:

A07AA Antibiotics 12 drugs
amphotericin BcolistinfidaxomicinkanamycinnatamycinneomycinparomomycinPolymyxin Brifamycinrifaximinstreptomycinvancomycin
D01AA Antibiotics 6 drugs
griseofulvinhachimycinmepartricinnatamycinpecilocinpyrrolnitrin
G01AA Antibiotics 10 drugs
amphotericin Bcandicidincarfecillinchloramphenicolclindamycinhachimycinmepartricinnatamycinoxytetracyclinepentamycin
J01RA Combinations of antibacterials 18 drugs
amikacinazithromycincefepimecefiximecefuroximeciprofloxacinfluconazolelevofloxacinmetronidazolenitazoxanidenorfloxacinofloxacin show all 18 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Mucocutaneous candidiasis indication 29147005
Candidiasis of skin indication 49883006
Candidal vulvovaginitis indication 72605008 DOID:2272
Candidiasis of mouth indication 79740000 DOID:14262
Gastrointestinal candidiasis indication 84679006
Diaper rash off-label use 91487003
Telangiectasia disorder contraindication 247479008
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006




🐶 Veterinary Drug Use

SpeciesUseRelation
Turkeys Control and treatment of crop mycosis Indication
Turkeys Mycotic diarrhea (Candida albicans) Indication

🐶 Veterinary products

ProductApplicantIngredients
Panolog Ointment Zoetis Inc. 4
Pharmastatin-20 Type A Medicated Article Zoetis Inc. 1
Panolog Cream Zoetis Inc. 4
DERMA-VET Ointment Med-Pharmex Inc. 4
Animax Ointment Fougera Pharmaceuticals Inc. 4
Derma 4 Ointment Zoetis Inc. 4
Derm-Otic Ointment Zoetis Inc. 4
Derma-Vet Cream Med-Pharmex Inc. 4
Animax Cream Fougera Pharmaceuticals Inc. 4

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.46 acidic
pKa2 10.11 acidic
pKa3 11.73 acidic
pKa4 12.54 acidic
pKa5 13.88 acidic
pKa6 13.96 acidic
pKa7 8.62 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017580 VUID
N0000145961 NUI
D00202 KEGG_DRUG
34786-70-4 SECONDARY_CAS_RN
4017580 VANDF
C0028741 UMLSCUI
CHEBI:7660 CHEBI
CHEMBL5465559 ChEMBL_ID
D009761 MESH_DESCRIPTOR_UI
DB00646 DRUGBANK_ID
539 INN_ID
BDF1O1C72E UNII
6433272 PUBCHEM_CID
7597 RXNORM
2828 MMSL
29922 MMSL
5194 MMSL
d01233 MMSL
002889 NDDF
12096000 SNOMEDCT_US
387048002 SNOMEDCT_US
A1AZ7 PDB_CHEM_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 0093-0983 TABLET, FILM COATED 500000 [USPU] ORAL ANDA 16 sections
Nystatin Oral Suspension HUMAN PRESCRIPTION DRUG LABEL 1 0116-4026 SUSPENSION 100000 [USPU] ORAL ANDA 19 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 0121-0810 SUSPENSION 100000 [USPU] ORAL ANDA 19 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 0121-0868 SUSPENSION 100000 [USPU] ORAL ANDA 19 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 0121-1045 SUSPENSION 100000 [USPU] ORAL ANDA 19 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 0121-4810 SUSPENSION 100000 [USPU] ORAL ANDA 19 sections
Nystatin Cream HUMAN PRESCRIPTION DRUG LABEL 1 0316-0221 CREAM 100000 [USPU] TOPICAL ANDA 18 sections
Nystatin Cream HUMAN PRESCRIPTION DRUG LABEL 1 0316-0221 CREAM 100000 [USPU] TOPICAL ANDA 18 sections
Nystatin and Triamcinolone Acetonide HUMAN PRESCRIPTION DRUG LABEL 2 0316-0223 CREAM 100000 [USPU] TOPICAL ANDA 18 sections
Nystatin and Triamcinolone Acetonide HUMAN PRESCRIPTION DRUG LABEL 2 0316-0223 CREAM 100000 [USPU] TOPICAL ANDA 18 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 0472-0166 OINTMENT 100000 [USPU] TOPICAL ANDA 9 sections
Nystop HUMAN PRESCRIPTION DRUG LABEL 1 0574-2008 POWDER 100000 [USPU] TOPICAL ANDA 20 sections
Nystop HUMAN PRESCRIPTION DRUG LABEL 1 0574-2008 POWDER 100000 [USPU] TOPICAL ANDA 20 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 0713-0678 CREAM 100000 [USPU] TOPICAL ANDA 18 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 0713-0686 OINTMENT 100000 [USPU] TOPICAL ANDA 13 sections
Nyamyc HUMAN PRESCRIPTION DRUG LABEL 1 0832-0465 POWDER 100000 [USPU] TOPICAL ANDA 22 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 0904-7276 SUSPENSION 100000 [USPU] ORAL ANDA 19 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 13668-534 OINTMENT 100000 U TOPICAL ANDA 17 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 13668-595 CREAM 100000 U TOPICAL ANDA 11 sections
Nystatin and Triamcinolone Acetonide HUMAN PRESCRIPTION DRUG LABEL 2 13668-610 CREAM 100000 [USPU] TOPICAL ANDA 10 sections
NYSTATIN AND TRIAMCINOLONE HUMAN PRESCRIPTION DRUG LABEL 2 16590-173 CREAM 100000 U TOPICAL ANDA 18 sections
NYSTATIN HUMAN PRESCRIPTION DRUG LABEL 1 16590-174 SUSPENSION 100000 [USPU] ORAL ANDA 19 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 17856-0037 SUSPENSION 100000 [USPU] ORAL ANDA 19 sections
NYSTATIN HUMAN PRESCRIPTION DRUG LABEL 1 17856-0508 SUSPENSION 100000 [USPU] ORAL ANDA 11 sections
NYSTATIN HUMAN PRESCRIPTION DRUG LABEL 1 17856-0509 SUSPENSION 100000 [USPU] ORAL ANDA 11 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 17856-0811 SUSPENSION 100000 [USPU] ORAL ANDA 19 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 17856-1008 SUSPENSION 100000 [USPU] ORAL ANDA 19 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 17856-1045 SUSPENSION 100000 [USPU] ORAL ANDA 19 sections
Nystatin and Triamcinolone HUMAN PRESCRIPTION DRUG LABEL 2 21695-185 CREAM 100000 [USPU] TOPICAL ANDA 20 sections
Nystatin HUMAN PRESCRIPTION DRUG LABEL 1 21695-643 SUSPENSION 100000 [USPU] ORAL ANDA 19 sections