Explore drug properties, targets, and indications with answers grounded in DrugCentral.
Powered by DrugCentral + retrieval-augmented AIAsk in your own words. Each question is answered independently.
Select a question to fill the editor, then ask it or make it your own.
Your answer will appear here. Open linked drug cards in a new tab to explore the source details.
Ask DrugCentral helps you explore drug properties, biological targets, and indications using natural language. Sample questions offer starting points, and linked drug cards let you check the underlying records.
Each request is independent; previous questions are not sent as conversation history. You can edit a sample before submitting, retry a failed request, or switch back to normal search. Drug links open in a new tab so your question and answer stay available.
Answers may contain mistakes or omit information. Verify details against DrugCentral records and original sources.
AI can make mistakes. Verify answers against the original sources before relying on them.
| Stem definition | Drug id | CAS RN |
|---|---|---|
| anti-inflammatory, anthranilic acid derivatives | 1663 | 61-68-7 |
| Dose | Unit | Route |
|---|---|---|
| 1 | g | O |
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 2 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.02 mg/mL | Bocci G, Oprea TI, Benet LZ |
| EoM (Fraction excreted unchanged in urine) | 1 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 74.01 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 52 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 1.950 | Moderate | 0.71 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.389 | Moderate | 0.71 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 92.257 | 10^-6 cm/s | Moderate | 0.71 |
| dh-clint | Dog hepatocyte intrinsic clearance | 137.721 | uL/min/10^6 cells | Moderate | 0.71 |
| dppb | Dog plasma protein binding (% unbound) | 0.400 | % | Moderate | 0.71 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 0.610 | % | Moderate | 0.71 |
| herg | hERG pIC50 | 4.308 | pIC50 | Moderate | 0.71 |
| hh-clint | Human hepatocyte intrinsic clearance | 116.145 | uL/min/10^6 cells | Moderate | 0.71 |
| hlm-clint | Human liver microsomal intrinsic clearance | 29.580 | uL/min/mg protein | Moderate | 0.71 |
| hppb | Human plasma protein binding (% unbound) | 0.290 | % | Moderate | 0.71 |
| kinase-safety-class | ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IKBKB,ITK,JAK1,JAK2,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK12,MAPK14,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 60 | |||
| kinase-selectivity-class | ACVR2A,ACVR2B,AXL,BRAF,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,JAK1,MAP2K6,MAPK7,MTOR,PDK4,SIK2,SIK3,STK33,TEK,TTK | 21 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 2.065 | Moderate | 0.71 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 118.850 | Moderate | 0.71 | |
| mppb | Mouse plasma protein binding (% unbound) | 1.030 | Moderate | 0.71 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 1.897 | Moderate | 0.71 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 0.980 | % | Moderate | 0.71 |
| rh-clint | Rat hepatocyte intrinsic clearance | 201.837 | uL/min/10^6 cells | Moderate | 0.71 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 50.630 | % | Moderate | 0.71 |
| rppb | Rat plasma protein binding (% unbound) | 0.270 | % | Moderate | 0.71 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 763.836 | uM | Moderate | 0.71 |
| Date | Agency | Company | Orphan |
|---|---|---|---|
| March 28, 1967 | FDA | SHIONOGI INC |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Infusion site coldness | 119.88 | 14.20 | 21 | 9885 | 214 | 90618327 |
| Vascular malformation | 112.35 | 14.20 | 24 | 9882 | 728 | 90617813 |
| Gamma-glutamyltransferase decreased | 110.88 | 14.20 | 21 | 9885 | 340 | 90618201 |
| Paranasal cyst | 110.58 | 14.20 | 24 | 9882 | 786 | 90617755 |
| Mastoiditis | 93.30 | 14.20 | 24 | 9882 | 1646 | 90616895 |
| Spinal pain | 84.45 | 14.20 | 39 | 9867 | 15728 | 90602813 |
| Infusion site induration | 80.29 | 14.20 | 21 | 9885 | 1538 | 90617003 |
| Stress | 79.37 | 14.20 | 68 | 9838 | 81327 | 90537214 |
| Mean cell haemoglobin decreased | 71.69 | 14.20 | 26 | 9880 | 5669 | 90612872 |
| Post-traumatic neck syndrome | 70.36 | 14.20 | 21 | 9885 | 2493 | 90616048 |
| Vasodilatation | 67.52 | 14.20 | 21 | 9885 | 2863 | 90615678 |
| Otitis media | 63.59 | 14.20 | 24 | 9882 | 5846 | 90612695 |
| Feeling cold | 58.99 | 14.20 | 37 | 9869 | 27428 | 90591113 |
| Infusion site haemorrhage | 54.58 | 14.20 | 21 | 9885 | 5390 | 90613151 |
| Vein disorder | 54.11 | 14.20 | 21 | 9885 | 5515 | 90613026 |
| Inflammatory marker increased | 49.99 | 14.20 | 23 | 9883 | 9191 | 90609350 |
| Retinal detachment | 49.86 | 14.20 | 21 | 9885 | 6801 | 90611740 |
| Peripheral coldness | 46.58 | 14.20 | 25 | 9881 | 13867 | 90604674 |
| Incontinence | 44.55 | 14.20 | 24 | 9882 | 13411 | 90605130 |
| Urinoma | 43.53 | 14.20 | 7 | 9899 | 40 | 90618501 |
| Blood creatinine decreased | 37.66 | 14.20 | 17 | 9889 | 6498 | 90612043 |
| Oropharyngeal pain | 35.85 | 14.20 | 53 | 9853 | 115134 | 90503407 |
| Gastroenteritis radiation | 35.71 | 14.20 | 9 | 9897 | 568 | 90617973 |
| Bladder prolapse | 35.41 | 14.20 | 12 | 9894 | 2143 | 90616398 |
| Tendon disorder | 34.09 | 14.20 | 16 | 9890 | 6684 | 90611857 |
| Injection site bruising | 32.38 | 14.20 | 34 | 9872 | 52273 | 90566268 |
| Dactylitis | 31.95 | 14.20 | 13 | 9893 | 3860 | 90614681 |
| Chills | 31.78 | 14.20 | 54 | 9852 | 131927 | 90486614 |
| Musculoskeletal disorder | 31.58 | 14.20 | 23 | 9883 | 21746 | 90596795 |
| Neutrophil count decreased | 31.54 | 14.20 | 39 | 9867 | 71493 | 90547048 |
| Oral lichenoid reaction | 31.40 | 14.20 | 6 | 9900 | 102 | 90618439 |
| Angioedema | 31.26 | 14.20 | 37 | 9869 | 64839 | 90553702 |
| Toothache | 31.15 | 14.20 | 23 | 9883 | 22207 | 90596334 |
| Rectal prolapse | 30.98 | 14.20 | 11 | 9895 | 2256 | 90616285 |
| Skin sensitisation | 30.68 | 14.20 | 9 | 9897 | 1006 | 90617535 |
| Urine osmolarity increased | 30.52 | 14.20 | 6 | 9900 | 119 | 90618422 |
| Disturbance in attention | 29.83 | 14.20 | 31 | 9875 | 47078 | 90571463 |
| Body temperature decreased | 29.74 | 14.20 | 23 | 9883 | 23793 | 90594748 |
| Pain in jaw | 29.36 | 14.20 | 31 | 9875 | 47954 | 90570587 |
| Poor venous access | 29.17 | 14.20 | 21 | 9885 | 19506 | 90599035 |
| Headache | 28.47 | 14.20 | 176 | 9730 | 862570 | 89755971 |
| Blood potassium increased | 28.02 | 14.20 | 21 | 9885 | 20728 | 90597813 |
| Enthesopathy | 26.25 | 14.20 | 15 | 9891 | 9389 | 90609152 |
| Dizziness | 25.22 | 14.20 | 129 | 9777 | 589155 | 90029386 |
| Metastases to bone | 24.21 | 14.20 | 21 | 9885 | 25484 | 90593057 |
| Arteriospasm coronary | 22.47 | 14.20 | 11 | 9895 | 5039 | 90613502 |
| Nephrogenic diabetes insipidus | 22.44 | 14.20 | 7 | 9899 | 963 | 90617578 |
| Systemic lupus erythematosus | 22.30 | 14.20 | 6 | 9900 | 361890 | 90256651 |
| Thermal burn | 22.19 | 14.20 | 12 | 9894 | 6750 | 90611791 |
| Gastritis | 22.10 | 14.20 | 25 | 9881 | 41728 | 90576813 |
| Therapeutic response decreased | 21.97 | 14.20 | 37 | 9869 | 89692 | 90528849 |
| Photosensitivity reaction | 21.80 | 14.20 | 17 | 9889 | 17790 | 90600751 |
| Eosinophil count increased | 21.70 | 14.20 | 15 | 9891 | 13066 | 90605475 |
| Hepatic function abnormal | 21.64 | 14.20 | 26 | 9880 | 46262 | 90572279 |
| Haemangioma | 21.02 | 14.20 | 9 | 9897 | 3033 | 90615508 |
| Pemphigus | 20.94 | 14.20 | 5 | 9901 | 326859 | 90291682 |
| Renal ischaemia | 20.55 | 14.20 | 6 | 9900 | 660 | 90617881 |
| Injection site inflammation | 20.53 | 14.20 | 10 | 9896 | 4531 | 90614010 |
| Renal papillary necrosis | 20.44 | 14.20 | 5 | 9901 | 279 | 90618262 |
| Drug reaction with eosinophilia and systemic symptoms | 19.96 | 14.20 | 24 | 9882 | 42734 | 90575807 |
| Cerebellar haemangioma | 19.74 | 14.20 | 4 | 9902 | 93 | 90618448 |
| Flushing | 19.72 | 14.20 | 35 | 9871 | 88456 | 90530085 |
| White blood cell count decreased | 19.69 | 14.20 | 51 | 9855 | 167058 | 90451483 |
| Rabbit syndrome | 19.55 | 14.20 | 5 | 9901 | 335 | 90618206 |
| Gastrointestinal inflammation | 19.55 | 14.20 | 11 | 9895 | 6685 | 90611856 |
| Death | 19.49 | 14.20 | 13 | 9893 | 456538 | 90162003 |
| Impaired driving ability | 19.30 | 14.20 | 10 | 9896 | 5163 | 90613378 |
| Post herpetic neuralgia | 18.74 | 14.20 | 8 | 9898 | 2676 | 90615865 |
| Wound | 18.70 | 14.20 | 5 | 9901 | 302975 | 90315566 |
| Mononeuropathy multiplex | 18.69 | 14.20 | 5 | 9901 | 399 | 90618142 |
| Glossodynia | 18.60 | 14.20 | 6 | 9900 | 321773 | 90296768 |
| Injection site mass | 18.60 | 14.20 | 17 | 9889 | 22073 | 90596468 |
| Tremor | 18.30 | 14.20 | 47 | 9859 | 153126 | 90465415 |
| Vitamin D decreased | 18.16 | 14.20 | 13 | 9893 | 11966 | 90606575 |
| Hand deformity | 18.09 | 14.20 | 5 | 9901 | 296357 | 90322184 |
| Throat tightness | 17.95 | 14.20 | 19 | 9887 | 29465 | 90589076 |
| Anxiety | 17.80 | 14.20 | 74 | 9832 | 309698 | 90308843 |
| Menopausal symptoms | 17.69 | 14.20 | 8 | 9898 | 3070 | 90615471 |
| Arthritis | 17.63 | 14.20 | 49 | 9857 | 167266 | 90451275 |
| Platelet count decreased | 17.38 | 14.20 | 43 | 9863 | 136926 | 90481615 |
| Crystal nephropathy | 17.32 | 14.20 | 6 | 9900 | 1145 | 90617396 |
| Abdominal pain upper | 17.22 | 14.20 | 77 | 9829 | 332597 | 90285944 |
| Blood pressure decreased | 17.17 | 14.20 | 30 | 9876 | 74865 | 90543676 |
| Injection site erythema | 17.06 | 14.20 | 35 | 9871 | 98467 | 90520074 |
| Arthropod bite | 16.81 | 14.20 | 11 | 9895 | 8756 | 90609785 |
| Injection site haemorrhage | 16.80 | 14.20 | 18 | 9888 | 28300 | 90590241 |
| Tubulointerstitial nephritis | 16.62 | 14.20 | 17 | 9889 | 25326 | 90593215 |
| Immunodeficiency | 16.58 | 14.20 | 22 | 9884 | 43212 | 90575329 |
| Vitamin B12 decreased | 16.26 | 14.20 | 9 | 9897 | 5301 | 90613240 |
| Citric acid urine increased | 16.05 | 14.20 | 3 | 9903 | 45 | 90618496 |
| Familial haemophagocytic lymphohistiocytosis | 15.99 | 14.20 | 3 | 9903 | 46 | 90618495 |
| Bone pain | 15.76 | 14.20 | 26 | 9880 | 61957 | 90556584 |
| Heavy menstrual bleeding | 15.75 | 14.20 | 15 | 9891 | 20515 | 90598026 |
| Hypogeusia | 15.58 | 14.20 | 6 | 9900 | 1543 | 90616998 |
| Tongue discomfort | 15.30 | 14.20 | 7 | 9899 | 2758 | 90615783 |
| Alopecia | 15.29 | 14.20 | 19 | 9887 | 495052 | 90123489 |
| Granulocyte percentage | 15.29 | 14.20 | 3 | 9903 | 59 | 90618482 |
| Feeling hot | 15.05 | 14.20 | 29 | 9877 | 77979 | 90540562 |
| Urine output increased | 14.83 | 14.20 | 6 | 9900 | 1756 | 90616785 |
| Lipaemic index score | 14.45 | 14.20 | 3 | 9903 | 79 | 90618462 |
| Influenza like illness | 14.38 | 14.20 | 29 | 9877 | 80582 | 90537959 |
| Pain in extremity | 14.21 | 14.20 | 91 | 9815 | 450438 | 90168103 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Heat stroke | 65.34 | 22.96 | 14 | 1861 | 1094 | 42618366 |
| Ankylosing spondylitis | 59.58 | 22.96 | 19 | 1856 | 7037 | 42612423 |
| Brain stem syndrome | 36.79 | 22.96 | 8 | 1867 | 669 | 42618791 |
| Mydriasis | 36.72 | 22.96 | 14 | 1861 | 8756 | 42610704 |
| Exposure to communicable disease | 33.05 | 22.96 | 6 | 1869 | 198 | 42619262 |
| Anhidrosis | 32.52 | 22.96 | 6 | 1869 | 217 | 42619243 |
| Lid sulcus deepened | 29.76 | 22.96 | 5 | 1870 | 104 | 42619356 |
| Vanishing bile duct syndrome | 28.71 | 22.96 | 8 | 1867 | 1863 | 42617597 |
| Alopecia | 25.66 | 22.96 | 16 | 1859 | 29260 | 42590200 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Vascular malformation | 118.98 | 14.90 | 25 | 10731 | 789 | 110577754 |
| Infusion site coldness | 118.73 | 14.90 | 21 | 10735 | 258 | 110578285 |
| Paranasal cyst | 116.37 | 14.90 | 25 | 10731 | 879 | 110577664 |
| Gamma-glutamyltransferase decreased | 111.12 | 14.90 | 21 | 10735 | 380 | 110578163 |
| Mastoiditis | 90.02 | 14.90 | 25 | 10731 | 2586 | 110575957 |
| Infusion site induration | 85.32 | 14.90 | 21 | 10735 | 1355 | 110577188 |
| Post-traumatic neck syndrome | 72.12 | 14.90 | 21 | 10735 | 2574 | 110575969 |
| Mean cell haemoglobin decreased | 68.80 | 14.90 | 26 | 10730 | 7148 | 110571395 |
| Spinal pain | 67.75 | 14.90 | 34 | 10722 | 18481 | 110560062 |
| Vasodilatation | 64.53 | 14.90 | 21 | 10735 | 3723 | 110574820 |
| Otitis media | 64.19 | 14.90 | 25 | 10731 | 7451 | 110571092 |
| Infusion site haemorrhage | 60.30 | 14.90 | 21 | 10735 | 4577 | 110573966 |
| Stress | 59.99 | 14.90 | 62 | 10694 | 105286 | 110473257 |
| Feeling cold | 58.16 | 14.90 | 38 | 10718 | 33949 | 110544594 |
| Vein disorder | 53.95 | 14.90 | 21 | 10735 | 6249 | 110572294 |
| Heat stroke | 46.53 | 14.90 | 14 | 10742 | 1921 | 110576622 |
| Peripheral coldness | 42.56 | 14.90 | 25 | 10731 | 18515 | 110560028 |
| Retinal detachment | 42.43 | 14.90 | 21 | 10735 | 11079 | 110567464 |
| Incontinence | 42.37 | 14.90 | 24 | 10732 | 16611 | 110561932 |
| Bladder prolapse | 41.54 | 14.90 | 12 | 10744 | 1430 | 110577113 |
| Angioedema | 39.00 | 14.90 | 48 | 10708 | 98452 | 110480091 |
| Oropharyngeal pain | 36.91 | 14.90 | 55 | 10701 | 135221 | 110443322 |
| Headache | 36.61 | 14.90 | 176 | 10580 | 882201 | 109696342 |
| Injection site bruising | 36.30 | 14.90 | 34 | 10722 | 51229 | 110527314 |
| Death | 35.31 | 14.90 | 12 | 10744 | 698857 | 109879686 |
| Toothache | 34.67 | 14.90 | 24 | 10732 | 23551 | 110554992 |
| Blood creatinine decreased | 34.07 | 14.90 | 17 | 10739 | 9120 | 110569423 |
| Gastroenteritis radiation | 33.75 | 14.90 | 9 | 10747 | 799 | 110577744 |
| Urinoma | 32.26 | 14.90 | 7 | 10749 | 258 | 110578285 |
| Rectal prolapse | 30.91 | 14.90 | 11 | 10745 | 2552 | 110575991 |
| Disturbance in attention | 30.88 | 14.90 | 34 | 10722 | 61961 | 110516582 |
| Skin sensitisation | 30.85 | 14.90 | 9 | 10747 | 1110 | 110577433 |
| Bone pain | 29.50 | 14.90 | 34 | 10722 | 65099 | 110513444 |
| Oral lichenoid reaction | 28.72 | 14.90 | 6 | 10750 | 184 | 110578359 |
| Body temperature decreased | 27.12 | 14.90 | 25 | 10731 | 36910 | 110541633 |
| Poor venous access | 27.08 | 14.90 | 21 | 10735 | 24501 | 110554042 |
| Inflammatory marker increased | 26.78 | 14.90 | 17 | 10739 | 14452 | 110564091 |
| Chills | 26.77 | 14.90 | 58 | 10698 | 190522 | 110388021 |
| Musculoskeletal disorder | 26.33 | 14.90 | 20 | 10736 | 22644 | 110555899 |
| Urine osmolarity increased | 25.99 | 14.90 | 6 | 10750 | 294 | 110578249 |
| Injection site haemorrhage | 25.51 | 14.90 | 23 | 10733 | 33005 | 110545538 |
| Pain in jaw | 25.37 | 14.90 | 28 | 10728 | 51149 | 110527394 |
| Anhidrosis | 24.12 | 14.90 | 6 | 10750 | 404 | 110578139 |
| Tendon disorder | 23.89 | 14.90 | 13 | 10743 | 8324 | 110570219 |
| Blood potassium increased | 23.43 | 14.90 | 22 | 10734 | 33227 | 110545316 |
| Therapeutic response decreased | 23.18 | 14.90 | 37 | 10719 | 96462 | 110482081 |
| Haemangioma | 22.71 | 14.90 | 9 | 10747 | 2807 | 110575736 |
| Metastases to bone | 22.58 | 14.90 | 21 | 10735 | 31351 | 110547192 |
| Lid sulcus deepened | 22.48 | 14.90 | 5 | 10751 | 207 | 110578336 |
| Injection site erythema | 22.47 | 14.90 | 36 | 10720 | 94140 | 110484403 |
| Neutrophil count decreased | 22.00 | 14.90 | 41 | 10715 | 120900 | 110457643 |
| Vanishing bile duct syndrome | 21.68 | 14.90 | 9 | 10747 | 3159 | 110575384 |
| Thermal burn | 21.63 | 14.90 | 12 | 10744 | 7976 | 110570567 |
| Influenza like illness | 21.37 | 14.90 | 34 | 10722 | 88378 | 110490165 |
| Post herpetic neuralgia | 21.33 | 14.90 | 9 | 10747 | 3292 | 110575251 |
| Arthritis | 21.28 | 14.90 | 49 | 10707 | 167537 | 110411006 |
| Injection site inflammation | 21.17 | 14.90 | 10 | 10746 | 4761 | 110573782 |
| Gastritis | 20.98 | 14.90 | 26 | 10730 | 53673 | 110524870 |
| Abdominal pain upper | 20.92 | 14.90 | 78 | 10678 | 349033 | 110229510 |
| Immunodeficiency | 20.56 | 14.90 | 22 | 10734 | 38816 | 110539727 |
| Cerebellar haemangioma | 20.21 | 14.90 | 4 | 10752 | 93 | 110578450 |
| Menopausal symptoms | 20.19 | 14.90 | 8 | 10748 | 2493 | 110576050 |
| Pain in extremity | 20.00 | 14.90 | 97 | 10659 | 487021 | 110091522 |
| Dizziness | 19.95 | 14.90 | 126 | 10630 | 698067 | 109880476 |
| Rabbit syndrome | 19.46 | 14.90 | 5 | 10751 | 384 | 110578159 |
| Vitamin D decreased | 19.30 | 14.90 | 13 | 10743 | 12202 | 110566341 |
| Crystal nephropathy | 18.79 | 14.90 | 7 | 10749 | 1849 | 110576694 |
| Renal papillary necrosis | 18.75 | 14.90 | 5 | 10751 | 444 | 110578099 |
| Injection site mass | 18.73 | 14.90 | 17 | 10739 | 24596 | 110553947 |
| Impaired driving ability | 18.44 | 14.90 | 10 | 10746 | 6360 | 110572183 |
| Mydriasis | 18.24 | 14.90 | 16 | 10740 | 22141 | 110556402 |
| Heavy menstrual bleeding | 18.04 | 14.90 | 14 | 10742 | 16351 | 110562192 |
| Vitamin B12 decreased | 17.33 | 14.90 | 9 | 10747 | 5248 | 110573295 |
| Urticaria | 17.26 | 14.90 | 69 | 10687 | 318788 | 110259755 |
| Nephrogenic diabetes insipidus | 16.92 | 14.90 | 7 | 10749 | 2438 | 110576105 |
| Enthesopathy | 16.72 | 14.90 | 12 | 10744 | 12466 | 110566077 |
| Ankylosing spondylitis | 16.44 | 14.90 | 13 | 10743 | 15599 | 110562944 |
| Citric acid urine increased | 16.05 | 14.90 | 3 | 10753 | 51 | 110578492 |
| Throat tightness | 16.04 | 14.90 | 18 | 10738 | 33471 | 110545072 |
| Flushing | 16 | 14.90 | 33 | 10723 | 104703 | 110473840 |
| Stem cell transplant | 15.81 | 14.90 | 8 | 10748 | 4419 | 110574124 |
| Tongue discomfort | 15.79 | 14.90 | 7 | 10749 | 2881 | 110575662 |
| Familial haemophagocytic lymphohistiocytosis | 15.68 | 14.90 | 3 | 10753 | 58 | 110578485 |
| Feeling hot | 15.47 | 14.90 | 30 | 10726 | 91076 | 110487467 |
| Injection site swelling | 15.26 | 14.90 | 24 | 10732 | 61766 | 110516777 |
| Infusion site pain | 15.19 | 14.90 | 13 | 10743 | 17406 | 110561137 |
| Granulocyte percentage | 15.03 | 14.90 | 3 | 10753 | 73 | 110578470 |
| Eosinophil count increased | 14.97 | 14.90 | 14 | 10742 | 21044 | 110557499 |
None
| Source | Code | Description |
|---|---|---|
| ATC | M01AG01 | MUSCULO-SKELETAL SYSTEM ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS Fenamates |
| FDA CS | M0001335 | Anti-Inflammatory Agents, Non-Steroidal |
| FDA MoA | N0000000160 | Cyclooxygenase Inhibitors |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D016861 | Cyclooxygenase Inhibitors |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory drug |
| CHEBI has role | CHEBI:35480 | analgesic |
| CHEBI has role | CHEBI:35493 | antipyretic |
| CHEBI has role | CHEBI:35526 | hypoglycemic agent |
| CHEBI has role | CHEBI:35544 | EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:35842 | antirheumatic drug |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
| FDA EPC | N0000175722 | Nonsteroidal Anti-inflammatory Drug |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Pain | indication | 22253000 | |
| Dysmenorrhea | indication | 266599000 | |
| Vascular headache | off-label use | 128187005 | |
| Peptic ulcer | contraindication | 13200003 | DOID:750 |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Gastrointestinal ulcer | contraindication | 40845000 | |
| Chronic heart failure | contraindication | 48447003 | |
| Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
| Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
| Gastrointestinal hemorrhage | contraindication | 74474003 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Coronary artery bypass graft | contraindication | 232717009 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Pregnancy, function | contraindication | 289908002 | |
| Cardiovascular event risk | contraindication | 395112001 | |
| Smokes tobacco daily | contraindication | 449868002 |
None
None
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.43 | acidic |
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | INHIBITOR | IC50 | 6.83 | WOMBAT-PK | CHEMBL | |||
| Prostaglandin G/H synthase 1 | Enzyme | INHIBITOR | IC50 | 4.78 | WOMBAT-PK | CHEMBL | |||
| Calcium-activated potassium channel subunit alpha-1 | Ion channel | ACTIVATOR | EC50 | 4 | IUPHAR | ||||
| Dihydrofolate reductase | Enzyme | Ki | 4.14 | CHEMBL | |||||
| Cytochrome P450 2C9 | Enzyme | EC50 | 5.30 | WOMBAT-PK | |||||
| Aldose reductase | Enzyme | IC50 | 4.11 | CHEMBL | |||||
| Aldo-keto reductase family 1 member C1 | Enzyme | Ki | 6.09 | CHEMBL | |||||
| Aldo-keto reductase family 1 member C2 | Enzyme | Ki | 6.66 | CHEMBL | |||||
| Aldo-keto reductase family 1 member C3 | Enzyme | Ki | 6.52 | CHEMBL | |||||
| Myeloperoxidase | Enzyme | IC50 | 6.01 | CHEMBL | |||||
| Transient receptor potential cation channel subfamily A member 1 | Ion channel | EC50 | 4.80 | CHEMBL | |||||
| Aldo-keto reductase family 1 member B10 | Enzyme | IC50 | 5.80 | CHEMBL | |||||
| Nicotinate phosphoribosyltransferase | Enzyme | Ki | 10.30 | CHEMBL | |||||
| Acetylcholinesterase | Enzyme | IC50 | 5.21 | CHEMBL | |||||
| NACHT, LRR and PYD domains-containing protein 3 | Cytosolic other | IC50 | 4.60 | CHEMBL |
| ID | Source |
|---|---|
| 4019082 | VUID |
| N0000147343 | NUI |
| D00151 | KEGG_DRUG |
| 4019082 | VANDF |
| C0025152 | UMLSCUI |
| CHEBI:6717 | CHEBI |
| ID8 | PDB_CHEM_ID |
| CHEMBL686 | ChEMBL_ID |
| DB00784 | DRUGBANK_ID |
| D008528 | MESH_DESCRIPTOR_UI |
| 4044 | PUBCHEM_CID |
| 2593 | IUPHAR_LIGAND_ID |
| 1494 | INN_ID |
| 367589PJ2C | UNII |
| 257844 | RXNORM |
| 5034 | MMSL |
| 91405 | MMSL |
| d00285 | MMSL |
| 001578 | NDDF |
| 116727007 | SNOMEDCT_US |
| 34364009 | SNOMEDCT_US |
| 387185008 | SNOMEDCT_US |
| 367589PJ2C | INXIGHT DRUGS |
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Mefenamic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0276-0509 | CAPSULE | 250 mg | ORAL | ANDA | 26 sections |
| Mefenamic acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42571-258 | CAPSULE | 250 mg | ORAL | ANDA | 27 sections |
| Mefenamic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68180-185 | CAPSULE | 250 mg | ORAL | ANDA | 25 sections |
| Mefenamic acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 72162-2382 | CAPSULE | 250 mg | ORAL | ANDA | 27 sections |
| Mefenamic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 80425-0306 | CAPSULE | 250 mg | ORAL | ANDA | 12 sections |
| Mefenamic Acid | HUMAN PRESCRIPTION DRUG LABEL | 1 | 80425-0423 | CAPSULE | 250 mg | ORAL | ANDA | 23 sections |