mebeverine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
spasmolytics with a papaverine-like action 1642 3625-06-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • mebeverine
  • mebeverine hydrochloride
  • CSAG 144
  • mebeverine HCl
  • Molecular weight: 429.56
  • Formula: C25H35NO5
  • CLOGP: 5.03
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 0
  • TPSA: 57.23
  • ALOGS: -5.17
  • ROTB: 14

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MARK4,MET,MTOR,NTRK2,PAK4,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ZAP70 52
kinase-selectivity-class AKT3,AXL,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,PDK4,PRKDC,SIK2,TEK,TTK 13
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Accidental overdose 100.77 24.64 45 5865 28228 90594309
Catarrh 90.10 24.64 21 5889 1613 90620924
Burns second degree 86.09 24.64 21 5889 1959 90620578
Steroid dependence 83.25 24.64 21 5889 2248 90620289
Anxiety disorder 75.62 24.64 23 5887 4899 90617638
Tinnitus 71.82 24.64 41 5869 43061 90579476
Hypopnoea 69.33 24.64 21 5889 4410 90618127
Parosmia 55.90 24.64 20 5890 7049 90615488
Gingival pain 53.32 24.64 21 5889 9631 90612906
Cardiac murmur 52.43 24.64 25 5885 18169 90604368
Swollen tongue 49.24 24.64 33 5877 45923 90576614
Nightmare 48.23 24.64 25 5885 21700 90600837
Vertigo 47.28 24.64 38 5872 69773 90552764
Vitamin D deficiency 47.19 24.64 23 5887 17533 90605004
Rhinitis 46.42 24.64 21 5889 13551 90608986
Myalgia 46.23 24.64 57 5853 175068 90447469
Dysgeusia 45.24 24.64 33 5877 52527 90570010
Bronchiectasis 44.75 24.64 24 5886 22306 90600231
Pulmonary embolism 43.58 24.64 48 5862 130772 90491765
Starvation ketoacidosis 42.43 24.64 8 5902 217 90622320
Palpitations 40.17 24.64 47 5863 136681 90485856
Metastatic neoplasm 39.49 24.64 14 5896 4801 90617736
Impaired work ability 39.37 24.64 21 5889 19305 90603232
Somnolence 38.33 24.64 57 5853 209027 90413510
Benign mediastinal neoplasm 38.22 24.64 6 5904 52 90622485
Mediastinal cyst 37.82 24.64 6 5904 56 90622481
Tubulointerstitial nephritis 36.64 24.64 22 5888 25321 90597216
Adjusted calcium decreased 36.10 24.64 7 5903 221 90622316
Impaired quality of life 35.83 24.64 21 5889 23123 90599414
Schizophrenia 35.53 24.64 18 5892 14896 90607641
Lip swelling 34.95 24.64 25 5885 38585 90583952
Eyelid sensory disorder 33.86 24.64 6 5904 114 90622423
Oesophageal irritation 33.29 24.64 7 5903 334 90622203
Iron deficiency anaemia 32.81 24.64 20 5890 23642 90598895
Angina pectoris 32.37 24.64 24 5886 39136 90583401
Splenic vein thrombosis 31.62 24.64 7 5903 426 90622111
Lagophthalmos 31.02 24.64 7 5903 465 90622072
Upper gastrointestinal haemorrhage 30.79 24.64 19 5891 22957 90599580
Pathological fracture 30.06 24.64 14 5896 9646 90612891
Eczema 30.02 24.64 26 5884 52844 90569693
Atrioventricular block complete 29.85 24.64 14 5896 9797 90612740
Dyspepsia 29.34 24.64 49 5861 198111 90424426
Delirium 29.19 24.64 35 5875 104324 90518213
Tooth deposit 28.75 24.64 6 5904 276 90622261
Haemorrhoids 28.17 24.64 19 5891 26683 90595854
Dermatitis atopic 27.92 24.64 18 5892 23454 90599083
False positive investigation result 27.41 24.64 7 5903 786 90621751
Lung neoplasm malignant 27.37 24.64 18 5892 24255 90598282
Suspected COVID-19 26.64 24.64 9 5901 2677 90619860
Chest pain 26.57 24.64 62 5848 319583 90302954
Rectal haemorrhage 25.21 24.64 29 5881 82715 90539822
Dermatitis allergic 24.94 24.64 15 5895 17312 90605225

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Gingival pain 286.77 71.43 84 5124 8410 42607717
Burns second degree 281.46 71.43 77 5131 6019 42610108
Catarrh 278.18 71.43 76 5132 5910 42610217
Steroid dependence 269.46 71.43 76 5132 6646 42609481
Parosmia 263.75 71.43 77 5131 7614 42608513
Hypopnoea 261.89 71.43 77 5131 7805 42608322
Systemic lupus erythematosus 249.12 71.43 77 5131 9247 42606880
Swollen tongue 239.67 71.43 92 5116 21139 42594988
Nightmare 228.47 71.43 93 5115 24919 42591208
Rhinitis 226.19 71.43 76 5132 11901 42604226
Cardiac murmur 225.29 71.43 77 5131 12698 42603429
Impaired work ability 213.68 71.43 73 5135 12018 42604109
Bronchiectasis 199.44 71.43 77 5131 17942 42598185
Frequent bowel movements 193.40 71.43 79 5129 21328 42594799
Medication error 187.63 71.43 88 5120 33066 42583061
Colitis ulcerative 181.32 71.43 80 5128 26095 42590032
Alcohol poisoning 179.10 71.43 57 5151 7517 42608610
Impaired quality of life 176.38 71.43 66 5142 14111 42602016
Migraine 173.85 71.43 77 5131 25337 42590790
Tinnitus 164.28 71.43 77 5131 28861 42587266
Eczema 164.12 71.43 81 5127 34005 42582122
Accidental overdose 159.64 71.43 75 5133 28255 42587872
Vertigo 154.67 71.43 78 5130 34269 42581858
Dysgeusia 149.15 71.43 76 5132 34113 42582014
Tubulointerstitial nephritis 148.98 71.43 74 5134 31474 42584653
Rectal haemorrhage 146.12 71.43 85 5123 49521 42566606
Stress 136.16 71.43 78 5130 44134 42571993
Arthritis 134.34 71.43 76 5132 41989 42574138
Loss of personal independence in daily activities 124.97 71.43 77 5131 49739 42566388
Palpitations 123.59 71.43 77 5131 50720 42565407
Haematochezia 120.95 71.43 80 5128 58356 42557771
Abdominal discomfort 107.12 71.43 82 5126 75173 42540954
Adverse drug reaction 104.51 71.43 62 5146 37372 42578755
Deep vein thrombosis 99.01 71.43 79 5129 76878 42539249
Intentional product use issue 97.26 71.43 76 5132 71757 42544370
Inappropriate schedule of product administration 83.91 71.43 79 5129 95823 42520304
Cerebrovascular accident 81.13 71.43 78 5130 97082 42519045
Depression 77.54 71.43 81 5127 111282 42504845
Pulmonary embolism 74.47 71.43 82 5126 119530 42496597

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Burns second degree 363.99 27.94 93 9793 7640 110571773
Catarrh 363.91 27.94 92 9794 7243 110572170
Steroid dependence 350.79 27.94 92 9794 8377 110571036
Hypopnoea 328.38 27.94 93 9793 11287 110568126
Gingival pain 324.02 27.94 99 9787 15637 110563776
Parosmia 319.27 27.94 94 9792 13086 110566327
Cardiac murmur 272.85 27.94 97 9789 24531 110554882
Rhinitis 261.96 27.94 92 9794 22453 110556960
Swollen tongue 258.28 27.94 120 9766 60242 110519171
Accidental overdose 256.37 27.94 114 9772 51720 110527693
Nightmare 243.31 27.94 101 9785 38762 110540651
Tinnitus 236.38 27.94 113 9773 60427 110518986
Bronchiectasis 232.36 27.94 96 9790 36397 110543016
Impaired work ability 229.49 27.94 87 9799 26332 110553081
Impaired quality of life 201.42 27.94 82 9804 29935 110549478
Alcohol poisoning 195.25 27.94 59 9827 8961 110570452
Dysgeusia 195.07 27.94 104 9782 69881 110509532
Vertigo 192.55 27.94 111 9775 86759 110492654
Tubulointerstitial nephritis 180.98 27.94 91 9795 54193 110525220
Eczema 172.62 27.94 97 9789 72196 110507217
Frequent bowel movements 168.32 27.94 95 9791 71295 110508118
Colitis ulcerative 163.85 27.94 96 9790 77267 110502146
Medication error 158.06 27.94 105 9781 105261 110474152
Rectal haemorrhage 155.08 27.94 109 9777 119724 110459689
Palpitations 148.50 27.94 119 9767 159093 110420320
Stress 136.69 27.94 96 9790 105252 110474161
Haematochezia 133.24 27.94 98 9788 115426 110463987
Pulmonary embolism 130.99 27.94 126 9760 214348 110365065
Adverse drug reaction 118.23 27.94 88 9798 105471 110473942
Deep vein thrombosis 116.64 27.94 98 9788 139789 110439624
Migraine 110.76 27.94 104 9782 171548 110407865
Loss of personal independence in daily activities 102.78 27.94 94 9792 149926 110429487
Arthritis 97.64 27.94 96 9790 167490 110411923
Somnolence 97.12 27.94 126 9760 297323 110282090
Inappropriate schedule of product administration 95.83 27.94 104 9782 203533 110375880
Cerebrovascular accident 91.31 27.94 96 9790 181188 110398225
Confusional state 74.97 27.94 143 9743 468537 110110876
Depression 69.15 27.94 111 9775 317224 110262189
COVID-19 65.08 27.94 94 9792 244966 110334447
Intentional product use issue 62.80 27.94 93 9793 247813 110331600
Systemic lupus erythematosus 60.99 27.94 93 9793 254245 110325168
Pain in extremity 51.76 27.94 126 9760 486992 110092421
Myalgia 50.06 27.94 79 9807 222302 110357111
Abdominal discomfort 46.29 27.94 106 9780 393752 110185661
Drug dispensed to wrong patient 45.19 27.94 11 9875 738 110578675
Lip swelling 43.21 27.94 36 9850 50631 110528782
Headache 36.78 27.94 166 9720 882211 109697202
Pharyngeal swelling 36.65 27.94 19 9867 12013 110567400
Benign mediastinal neoplasm 36.33 27.94 6 9880 52 110579361
Weight decreased 35.52 27.94 107 9779 467950 110111463
Mediastinal cyst 35.47 27.94 6 9880 61 110579352
Adjusted calcium decreased 33.06 27.94 7 9879 250 110579163
Eyelid sensory disorder 32.83 27.94 6 9880 98 110579315
Pneumonia 31.23 27.94 20 9866 876694 109702719

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A03AA04 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
Synthetic anticholinergics, esters with tertiary amino group
MeSH PA D000927 Anticonvulsants
MeSH PA D002491 Central Nervous System Agents
MeSH PA D010276 Parasympatholytics
MeSH PA D018373 Peripheral Nervous System Agents
CHEBI has role CHEBI:53784 antispasmodic drug

Related Drugs by ATC class:

A03AA Synthetic anticholinergics, esters with tertiary amino group 8 drugs
camylofindicycloverinedifemerinedihexyverineoxyphencycliminepiperidolaterociverinetrimebutine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Irritable bowel syndrome indication 10743008 DOID:9778




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.31 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D04868 KEGG_DRUG
C0065832 UMLSCUI
CHEBI:748080 CHEBI
CHEMBL282121 ChEMBL_ID
CHEMBL1446650 ChEMBL_ID
DB12554 DRUGBANK_ID
C005096 MESH_SUPPLEMENTAL_RECORD_UI
4031 PUBCHEM_CID
9011 IUPHAR_LIGAND_ID
1191 INN_ID
2753-45-9 SECONDARY_CAS_RN
7F80CC3NNV UNII
235827 RXNORM
003995 NDDF
003996 NDDF
349819003 SNOMEDCT_US
395779008 SNOMEDCT_US
419830007 SNOMEDCT_US

Pharmaceutical products:

None