lysine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1622 56-87-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • L-Lysine
  • lysine
  • L-(+)-Lysine
  • lysine hydrochloride
  • lysine HCl
An essential amino acid. It is often added to animal feed.
  • Molecular weight: 146.19
  • Formula: C6H14N2O2
  • CLOGP: -3.42
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 89.34
  • ALOGS: -0.14
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.560 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.239 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 1.406 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 1.288 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 91.360 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 37.380 % High 1
herg hERG pIC50 5.169 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.429 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 8.810 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 93.820 % High 1
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,IKBKB,ITK,JAK3,KDR,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,NTRK1,NTRK2,PDK2,PDK4,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 39
kinase-selectivity-class AXL,CAMK2D,CDK4,CDK9,EIF2AK3,EPHB4,GRK2,MAP2K6,MAP3K14,MAPK7,STK33,SYK,TEK,TGFBR1 14
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 3.715 High 1
mh-clint Mouse hepatocyte intrinsic clearance 1.081 High 1
mppb Mouse plasma protein binding (% unbound) 97.090 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.059 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 96.380 % High 1
rh-clint Rat hepatocyte intrinsic clearance 3.999 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 78.090 % High 1
rppb Rat plasma protein binding (% unbound) 98.560 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 517.607 uM High 1

Approvals:

DateAgencyCompanyOrphan
June 23, 2021 PMDA FUJIFILM TOYAMA CHEMICAL Co., Ltd.
None FDA
July 25, 2019 EMA Advanced Accelerator Applications

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hand deformity 126.63 9.73 13 52903 296349 90279182
Pemphigus 117.35 9.73 24 52892 326840 90248691
Electric shock 112.06 9.73 41 52875 1681 90573850
Systemic lupus erythematosus 110.12 9.73 37 52879 361859 90213672
Low turnover osteopathy 100.02 9.73 49 52867 4169 90571362
Macular degeneration 98.22 9.73 116 52800 37854 90537677
Treatment failure 97.97 9.73 28 52888 303900 90271631
Maternal exposure during pregnancy 87.24 9.73 51 52865 360012 90215519
Duodenal ulcer perforation 86.48 9.73 13 52903 221275 90354256
Back pain 85.30 9.73 389 52527 316786 90258745
Rheumatoid factor positive 80.32 9.73 5 52911 171645 90403886
Femur fracture 79.03 9.73 115 52801 45967 90529564
Intervertebral discitis 76.88 9.73 42 52874 4478 90571053
Drug intolerance 75.68 9.73 90 52826 447501 90128030
Post-traumatic stress disorder 75.44 9.73 48 52868 6780 90568751
Therapy cessation 73.18 9.73 98 52818 36263 90539268
Glossodynia 70.56 9.73 51 52865 321728 90253803
Synovitis 70.07 9.73 54 52862 329698 90245833
Multiple sclerosis 68.62 9.73 83 52833 27757 90547774
Temperature intolerance 67.30 9.73 56 52860 11974 90563557
Rheumatic fever 67.26 9.73 6 52910 153115 90422416
Helicobacter infection 65.88 9.73 25 52891 226825 90348706
Post cholecystectomy syndrome 64.93 9.73 23 52893 858 90574673
Constipation 63.20 9.73 327 52589 280068 90295463
Toxicity to various agents 62.61 9.73 46 52870 287800 90287731
Pericarditis 61.62 9.73 41 52875 270110 90305421
Wound 61.39 9.73 52 52864 302928 90272603
Vitamin B12 increased 61.33 9.73 27 52889 1799 90573732
Blood immunoglobulin A increased 59.96 9.73 24 52892 1259 90574272
Off label use 58.84 9.73 390 52526 1101862 89473669
C-reactive protein abnormal 58.76 9.73 4 52912 127425 90448106
Chronic sinusitis 58.73 9.73 71 52845 23731 90551800
Contraindicated product administered 56.65 9.73 62 52854 320077 90255454
General physical health deterioration 56.24 9.73 75 52841 355040 90220491
Vitamin D deficiency 54.54 9.73 59 52857 17497 90558034
Demyelination 54.28 9.73 42 52874 8098 90567433
Muscle spasticity 53.23 9.73 83 52833 35239 90540292
Granulocyte count increased 52.55 9.73 23 52893 1511 90574020
Blood uric acid increased 51.92 9.73 40 52876 7664 90567867
Hypocholesterolaemia 51.32 9.73 37 52879 6412 90569119
Radiculopathy 50.29 9.73 58 52858 18447 90557084
Weight decreased 49.91 9.73 386 52530 379524 90196007
Swollen joint count increased 49.82 9.73 4 52912 111202 90464329
Completed suicide 49.30 9.73 12 52904 145046 90430485
Glomerular filtration rate increased 49.05 9.73 24 52892 2036 90573495
Vaginal flatulence 47.41 9.73 47 52869 12591 90562940
Anti-cyclic citrullinated peptide antibody positive 47.36 9.73 41 52875 236392 90339139
Therapeutic product effect decreased 46.67 9.73 56 52860 277515 90298016
Hyperlipidaemia 46.47 9.73 62 52854 22854 90552677
Aspartate aminotransferase 45.75 9.73 17 52899 728 90574803
Intervertebral disc degeneration 45.04 9.73 53 52863 17221 90558310
Depression 44.34 9.73 314 52602 300287 90275244
Balance disorder 44.24 9.73 141 52775 96939 90478592
Proctitis 43.46 9.73 49 52867 15210 90560321
Discomfort 43.36 9.73 58 52858 274277 90301254
Rheumatoid factor increased 42.66 9.73 23 52893 2388 90573143
Product use issue 42.45 9.73 80 52836 329839 90245692
Female genital tract fistula 41.98 9.73 52 52864 17816 90557715
Anaemia postoperative 41.66 9.73 22 52894 2191 90573340
Vaginal discharge 41.54 9.73 54 52862 19410 90556121
Joint noise 41.30 9.73 30 52886 5260 90570271
Fall 40.64 9.73 445 52471 481365 90094166
Liver injury 40.09 9.73 25 52891 170542 90404989
Arthropathy 39.50 9.73 98 52818 366144 90209387
Swelling 39.33 9.73 120 52796 418938 90156593
Progressive multifocal leukoencephalopathy 39.11 9.73 47 52869 15608 90559923
Paraesthesia oral 39.08 9.73 68 52848 31591 90543940
Coordination abnormal 37.63 9.73 54 52862 21302 90554229
Spinal osteoarthritis 37.60 9.73 51 52865 19097 90556434
Red blood cell count decreased 37.11 9.73 83 52833 46268 90529263
Drug abuse 36.78 9.73 3 52913 82344 90493187
Gastrooesophageal reflux disease 36.75 9.73 193 52723 166144 90409387
Intramedullary rod insertion 36.43 9.73 20 52896 2152 90573379
Intentional product use issue 36.19 9.73 44 52872 216848 90358683
Sleep disorder due to general medical condition, insomnia type 34.43 9.73 16 52900 128678 90446853
Intentional overdose 33.41 9.73 7 52909 93827 90481704
Drug interaction 33.01 9.73 70 52846 276383 90299148
Dry eye 32.92 9.73 91 52825 57840 90517691
Procedural pain 32.83 9.73 65 52851 33295 90542236
Dactylitis 32.62 9.73 23 52893 3850 90571681
Spinal disorder 32.40 9.73 37 52879 11642 90563889
Haematochezia 32.31 9.73 103 52813 70810 90504721
Ear pain 32.15 9.73 90 52826 57612 90517919
Mobility decreased 32.06 9.73 61 52855 250673 90324858
Asthenia 31.75 9.73 462 52454 533289 90042242
Diarrhoea 31.41 9.73 743 52173 938447 89637084
Exposure during pregnancy 31.37 9.73 57 52859 238353 90337178
Diverticulum 31.31 9.73 37 52879 12076 90563455
Coronary artery disease 31.28 9.73 64 52852 33559 90541972
Headache 31.17 9.73 690 52226 862056 89713475
Infective pulmonary exacerbation of cystic fibrosis 30.98 9.73 34 52882 10245 90565286
Drug ineffective 30.51 9.73 598 52318 1383700 89191831
Throat clearing 30.45 9.73 22 52894 3825 90571706
Stress fracture 30.42 9.73 31 52885 8580 90566951
Oral candidiasis 30.09 9.73 65 52851 35390 90540141
Flatulence 29.73 9.73 71 52845 41296 90534235
Depressed mood 29.64 9.73 80 52836 50142 90525389
Blood test abnormal 28.51 9.73 47 52869 20905 90554626
Neuropathy peripheral 28.26 9.73 156 52760 136814 90438717
Intervertebral disc protrusion 27.99 9.73 54 52862 27142 90548389
Prescribed overdose 27.92 9.73 11 52905 97614 90477917
Hypersensitivity 27.73 9.73 154 52762 454523 90121008
Febrile neutropenia 27.62 9.73 31 52885 158318 90417213
Confusional state 27.44 9.73 124 52792 386081 90189450
Ill-defined disorder 27.30 9.73 41 52875 184850 90390681
Vitamin B12 deficiency 26.54 9.73 27 52889 7459 90568072
Dental caries 26.50 9.73 33 52883 11364 90564167
Cholecystitis acute 26.44 9.73 30 52886 9374 90566157
Muscle injury 26.25 9.73 39 52877 176615 90398916
Wheezing 26.21 9.73 63 52853 238017 90337514
Muscle strain 25.72 9.73 30 52886 9657 90565874
Bronchitis 25.66 9.73 165 52751 152762 90422769
Cystocele 25.39 9.73 14 52902 1520 90574011
Lumbar spinal stenosis 25.15 9.73 23 52893 5574 90569957
Blood pressure systolic decreased 25.10 9.73 29 52887 9241 90566290
Product use in unapproved indication 25.07 9.73 106 52810 336130 90239401
Musculoskeletal stiffness 24.98 9.73 89 52827 296443 90279088
Fibromyalgia 24.81 9.73 52 52864 206217 90369314
Infection 24.69 9.73 118 52798 361976 90213555
Dizziness 24.39 9.73 481 52435 588803 89986728
Spinal epidural haematoma 24.37 9.73 13 52903 1321 90574210
Ulcer 24.24 9.73 57 52859 32825 90542706
Injury 23.52 9.73 50 52866 197299 90378232
Product dose omission issue 23.45 9.73 267 52649 291420 90284111
Body temperature increased 23.22 9.73 68 52848 44642 90530889
Abdominal discomfort 22.84 9.73 174 52742 477154 90098377
Transient ischaemic attack 22.75 9.73 66 52850 43110 90532421
Mitral valve incompetence 22.30 9.73 44 52872 22480 90553051
Myalgia 21.88 9.73 176 52740 174949 90400582
Throat irritation 21.52 9.73 70 52846 48625 90526906
Therapy non-responder 21.48 9.73 29 52887 136675 90438856
Overdose 21.38 9.73 37 52879 157672 90417859
Urinary incontinence 21.33 9.73 59 52857 37507 90538024
Blood glucose decreased 21.09 9.73 44 52872 23385 90552146
Bladder prolapse 20.99 9.73 14 52902 2141 90573390
Frequent bowel movements 20.94 9.73 77 52839 56858 90518673
Spondylolisthesis 20.81 9.73 18 52898 4057 90571474
Product complaint 20.72 9.73 32 52884 13468 90562063
Adjustment disorder with depressed mood 20.69 9.73 4 52912 56749 90518782
Aspartate aminotransferase abnormal 20.63 9.73 15 52901 2634 90572897
Monocyte count increased 20.61 9.73 26 52890 9071 90566460
Blood calcium increased 20.53 9.73 30 52886 12028 90563503
Acute kidney injury 20.35 9.73 107 52809 320280 90255251
Fracture nonunion 20.21 9.73 14 52902 2278 90573253
Adrenal insufficiency 20.06 9.73 50 52866 29871 90545660
Glycosylated haemoglobin increased 19.96 9.73 34 52882 15528 90560003
Grip strength decreased 19.84 9.73 15 52901 92561 90482970
Blood alkaline phosphatase increased 19.37 9.73 67 52849 48012 90527519
Body height decreased 19.30 9.73 29 52887 11920 90563611
Neutropenia 19.27 9.73 67 52849 224837 90350694
Gastrointestinal disorder 19.08 9.73 81 52835 256606 90318925
Folliculitis 18.80 9.73 59 52857 204294 90371237
Dysphagia 18.74 9.73 121 52795 112157 90463374
Urinary tract infection 18.71 9.73 266 52650 305366 90270165
Muscle spasms 18.66 9.73 227 52689 251656 90323875
Night sweats 18.66 9.73 134 52782 128632 90446899
Deep vein thrombosis postoperative 18.63 9.73 9 52907 70800 90504731
Alopecia 18.60 9.73 192 52724 494879 90080652
Facet joint syndrome 18.57 9.73 18 52898 98371 90477160
Malignant neoplasm progression 18.55 9.73 21 52895 106849 90468682
Type 2 diabetes mellitus 18.47 9.73 59 52857 203185 90372346
Delusional disorder, persecutory type 18.32 9.73 7 52909 324 90575207
Interstitial lung disease 18.22 9.73 11 52905 76394 90499137
Abdominal pain upper 17.82 9.73 283 52633 332391 90243140
Cardiac arrest 17.80 9.73 21 52895 104914 90470617
Condition aggravated 17.75 9.73 243 52673 595302 89980229
Feeling abnormal 17.70 9.73 162 52754 167073 90408458
C-reactive protein increased 17.67 9.73 51 52865 181338 90394193
Drug-induced liver injury 17.67 9.73 16 52900 90302 90485229
Blood urea increased 17.50 9.73 48 52868 30365 90545166
Hot flush 17.48 9.73 75 52841 59413 90516118
Ventricular hypertrophy 17.36 9.73 15 52901 3376 90572155
Stress urinary incontinence 17.11 9.73 13 52903 2439 90573092
Osteopenia 17.09 9.73 40 52876 22962 90552569
White blood cells urine positive 17.04 9.73 20 52896 6478 90569053
Respiratory disorder 17.00 9.73 79 52837 64737 90510794
Bone loss 16.98 9.73 15 52901 3477 90572054
Syncope 16.93 9.73 134 52782 132529 90443002
Drug hypersensitivity 16.92 9.73 181 52735 463428 90112103
Cough 16.90 9.73 306 52610 368656 90206875
Bone erosion 16.85 9.73 5 52911 53016 90522515
Bone pain 16.59 9.73 76 52840 61907 90513624
Pancytopenia 16.49 9.73 28 52888 120235 90455296
Renal cyst 16.22 9.73 28 52888 12922 90562609
White blood cell count decreased 15.76 9.73 158 52758 166951 90408580
Pulmonary fibrosis 15.71 9.73 24 52892 107479 90468052
Hepatic enzyme increased 15.63 9.73 135 52781 360601 90214930
Foot fracture 15.31 9.73 42 52874 26564 90548967
Miosis 15.29 9.73 23 52893 9461 90566070
Distal intestinal obstruction syndrome 15.23 9.73 7 52909 516 90575015
Blister 15.18 9.73 87 52829 254911 90320620
Joint swelling 15.12 9.73 205 52711 503095 90072436
Oedema 15.00 9.73 63 52853 200232 90375299
Vision blurred 14.96 9.73 113 52803 110180 90465351
Tooth disorder 14.93 9.73 46 52870 31044 90544487
Cataract 14.79 9.73 82 52834 72010 90503521
Cerumen impaction 14.78 9.73 9 52907 1177 90574354
Benign vulval neoplasm 14.55 9.73 4 52912 63 90575468
Limb asymmetry 14.40 9.73 8 52908 881 90574650
Live birth 14.33 9.73 15 52901 79092 90496439
Lip dry 14.31 9.73 23 52893 100932 90474599
Aspartate aminotransferase increased 14.27 9.73 106 52810 102831 90472700
Pain in extremity 14.25 9.73 354 52562 450175 90125356
Liver disorder 14.22 9.73 31 52885 121238 90454293
Tooth fracture 14.18 9.73 26 52890 12574 90562957
Suicide attempt 13.99 9.73 14 52902 75385 90500146
Angina unstable 13.98 9.73 19 52897 7124 90568407
Lactic acidosis 13.92 9.73 6 52910 50457 90525074
Multiple sclerosis relapse 13.90 9.73 64 52852 52241 90523290
Sinus disorder 13.87 9.73 48 52868 34399 90541132
Drug reaction with eosinophilia and systemic symptoms 13.65 9.73 4 52912 42754 90532777
Cyst 13.64 9.73 30 52886 16531 90559000
Low density lipoprotein increased 13.60 9.73 20 52896 8065 90567466
Aortic valve incompetence 13.55 9.73 18 52898 6606 90568925
Myocardial infarction 13.50 9.73 107 52809 105865 90469666
Wound infection 13.49 9.73 26 52890 106376 90469155
Gingival disorder 13.44 9.73 14 52902 3977 90571554
Autoimmune disorder 13.40 9.73 15 52901 76729 90498802
Pyrexia 13.36 9.73 289 52627 660196 89915335
Metabolic acidosis 13.30 9.73 8 52908 55668 90519863
Rotator cuff syndrome 13.30 9.73 29 52887 15890 90559641
Haemorrhoids 13.28 9.73 40 52876 26662 90548869
Alanine aminotransferase increased 13.22 9.73 116 52800 118222 90457309
Hip arthroplasty 13.19 9.73 15 52901 76193 90499338
X-ray abnormal 13.18 9.73 5 52911 45419 90530112
Stress 13.15 9.73 87 52829 81308 90494223
Spinal compression fracture 13.08 9.73 28 52888 15150 90560381
Insomnia 13.03 9.73 270 52646 333204 90242327
Psoriatic arthropathy 13.01 9.73 79 52837 228256 90347275
Dry skin 12.96 9.73 92 52824 87981 90487550
Cardiac failure congestive 12.76 9.73 100 52816 98594 90476937
Nausea 12.72 9.73 780 52136 1109536 89465995
Death 12.63 9.73 189 52727 456362 90119169
Rib fracture 12.59 9.73 39 52877 26396 90549135
Blood triglycerides increased 12.57 9.73 26 52890 13735 90561796
Thrombocytopenia 12.54 9.73 71 52845 208654 90366877
Eye irritation 12.53 9.73 46 52870 33932 90541599
Dry mouth 12.40 9.73 163 52753 183896 90391635
Fatigue 12.36 9.73 806 52110 1153217 89422314
Upper limb fracture 12.36 9.73 34 52882 21544 90553987
Medication error 12.27 9.73 19 52897 84633 90490898
Scoliosis 12.14 9.73 20 52896 8887 90566644
Onychomadesis 11.87 9.73 6 52910 45992 90529539
Skin cancer 11.72 9.73 25 52891 13494 90562037
Cognitive disorder 11.70 9.73 75 52841 69332 90506199
Lupus-like syndrome 11.69 9.73 7 52909 48839 90526692
Infantile apnoea 11.67 9.73 8 52908 1279 90574252
Lower respiratory tract infection 11.67 9.73 92 52824 250567 90324964
Thrombosis 11.65 9.73 78 52838 73173 90502358
Nasal congestion 11.62 9.73 86 52830 83328 90492203
Cataract operation 11.47 9.73 16 52900 6147 90569384
Epilepsy 11.40 9.73 19 52897 82187 90493344
Endodontic procedure 11.36 9.73 12 52904 3463 90572068
Musculoskeletal chest pain 11.28 9.73 35 52881 23715 90551816
Cardiac failure 11.24 9.73 30 52886 109466 90466065
Coeliac disease 11.24 9.73 6 52910 44604 90530927
Hepatitis B antibody positive 11.17 9.73 3 52913 43 90575488
Influenza like illness 11.16 9.73 83 52833 80528 90495003
Traumatic arthritis 11.11 9.73 3 52913 44 90575487
Oral pain 11.02 9.73 43 52873 32640 90542891
Eye pain 10.97 9.73 53 52863 44115 90531416
Uterine prolapse 10.96 9.73 8 52908 1412 90574119
Ageusia 10.92 9.73 27 52889 16049 90559482
Nervousness 10.84 9.73 44 52872 34012 90541519
Breast fibrosis 10.81 9.73 3 52913 49 90575482
Pelvic fracture 10.80 9.73 26 52890 15193 90560338
Hiatus hernia 10.79 9.73 36 52880 25325 90550206
Prescribed underdose 10.72 9.73 17 52899 75002 90500529
Hysterectomy 10.71 9.73 22 52894 11562 90563969
Finger deformity 10.64 9.73 3 52913 32894 90542637
Laryngeal pain 10.60 9.73 13 52903 4409 90571122
Anxiety 10.57 9.73 246 52670 309526 90266005
Delirium 10.41 9.73 29 52887 104330 90471201
Tardive dyskinesia 10.40 9.73 21 52895 10909 90564622
Lung neoplasm 10.39 9.73 16 52900 6719 90568812
Carotid bruit 10.39 9.73 6 52910 712 90574819
Carpal tunnel syndrome 10.21 9.73 34 52882 23894 90551637
Bradycardia 10.19 9.73 21 52895 83826 90491705
Walking aid user 10.15 9.73 4 52912 35502 90540029
Cystic fibrosis 10.12 9.73 12 52904 3929 90571602
Drug eruption 10.11 9.73 4 52912 35403 90540128
Diet noncompliance 10.10 9.73 5 52911 435 90575096
Sleep apnoea syndrome 10.09 9.73 41 52875 31706 90543825
Coronary artery occlusion 10.07 9.73 18 52898 8536 90566995
Milk allergy 10.05 9.73 5 52911 440 90575091
Sciatic nerve injury 10.04 9.73 6 52910 758 90574773
Open reduction of fracture 10.02 9.73 7 52909 1155 90574376
Bone disorder 10.00 9.73 33 52883 23087 90552444
Cervicobrachial syndrome 10.00 9.73 7 52909 1158 90574373
Agranulocytosis 9.92 9.73 4 52912 34998 90540533
Pregnancy 9.91 9.73 13 52903 62034 90513497
Osteoarthritis 9.91 9.73 165 52751 195565 90379966
Lacunar infarction 9.88 9.73 11 52905 3366 90572165
Incisional drainage 9.83 9.73 5 52911 461 90575070
Bone marrow oedema syndrome 9.76 9.73 3 52913 71 90575460
Aortic valve sclerosis 9.76 9.73 7 52909 1203 90574328

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood phosphorus increased 82.80 12.84 61 21795 12464 42587015
Appendicolith 81.10 12.84 62 21794 13394 42586085
Blood cholesterol increased 76.68 12.84 81 21775 26660 42572819
Fractional exhaled nitric oxide increased 64.55 12.84 26 21830 1583 42597896
Toxicity to various agents 64.11 12.84 19 21837 229117 42370362
Appendicitis 63.70 12.84 65 21791 20548 42578931
Coronary artery disease 63.18 12.84 105 21751 53615 42545864
Infective pulmonary exacerbation of cystic fibrosis 63.07 12.84 43 21813 7775 42591704
Stress 61.05 12.84 93 21763 44119 42555360
Myasthenia gravis 57.50 12.84 55 21801 16082 42583397
Blood uric acid increased 57.32 12.84 54 21802 15493 42583986
Plantar fasciitis 54.19 12.84 28 21828 3042 42596437
Dry mouth 51.03 12.84 81 21775 39798 42559681
Ventricular fibrillation 48.29 12.84 68 21788 30055 42569424
Hyperlipidaemia 47.68 12.84 57 21799 21459 42578020
Sensation of foreign body 47.21 12.84 27 21829 3586 42595893
Drug interaction 46.69 12.84 41 21815 266958 42332521
Cardiogenic shock 46.44 12.84 73 21783 35567 42563912
Hyperphosphataemia 45.72 12.84 44 21812 12960 42586519
Myoglobin blood increased 44.09 12.84 26 21830 3656 42595823
Constipation 43.08 12.84 181 21675 162110 42437369
Acute kidney injury 42.77 12.84 77 21779 367260 42232219
Activated partial thromboplastin time prolonged 38.35 12.84 44 21812 15859 42583620
Iron deficiency 38.08 12.84 37 21819 11024 42588455
Analgesic therapy 36.99 12.84 29 21827 6495 42592984
Hypophosphataemia 36.15 12.84 49 21807 20896 42578583
Drug therapy 35.40 12.84 28 21828 6352 42593127
Abdominal distension 34.90 12.84 98 21758 71637 42527842
Ascites 34.28 12.84 84 21772 56594 42542885
Brain natriuretic peptide increased 33.94 12.84 28 21828 6742 42592737
Neuralgia 32.67 12.84 52 21804 25595 42573884
Bacterial infection 32.10 12.84 54 21802 27825 42571654
Sleep disorder 32.03 12.84 74 21782 48021 42551458
Chronic obstructive pulmonary disease 31.46 12.84 87 21769 63027 42536452
Completed suicide 30.85 12.84 6 21850 96459 42503020
Sleep disorder therapy 29.43 12.84 26 21830 6868 42592611
Off label use 28.68 12.84 201 21655 638134 41961345
Muscle spasms 27.68 12.84 102 21754 85942 42513537
Secretion discharge 27.15 12.84 26 21830 7609 42591870
Thrombosis 26.18 12.84 86 21770 68425 42531054
Febrile neutropenia 24.29 12.84 36 21820 185667 42413812
Incorrect route of product administration 23.99 12.84 44 21812 24261 42575218
Cardiac disorder 23.94 12.84 67 21789 48865 42550614
Exostosis 23.56 12.84 21 21835 5610 42593869
Chest discomfort 23.54 12.84 79 21777 63537 42535942
Diabetes mellitus 23.47 12.84 76 21780 60011 42539468
Drug ineffective 22.94 12.84 210 21646 629987 41969492
Dyspnoea exertional 21.96 12.84 66 21790 50082 42549397
Rubber sensitivity 21.36 12.84 8 21848 400 42599079
Anticoagulant therapy 21.17 12.84 18 21838 4517 42594962
Overdose 21.12 12.84 14 21842 105250 42494229
Antacid therapy 20.55 12.84 18 21838 4699 42594780
Nasopharyngitis 20.19 12.84 91 21765 83905 42515574
Therapy cessation 20.15 12.84 37 21819 20413 42579066
Blood calcium increased 19.72 12.84 23 21833 8431 42591048
Malignant neoplasm progression 19.70 12.84 16 21840 108384 42491095
Dysphonia 19.18 12.84 44 21812 28406 42571073
Aortic stenosis 19.10 12.84 23 21833 8722 42590757
Swelling 18.43 12.84 66 21790 54819 42544660
Cardiac failure 17.93 12.84 17 21839 106839 42492640
Treatment failure 17.83 12.84 5 21851 62619 42536860
Gout 17.40 12.84 42 21814 28013 42571466
Hepatic function abnormal 16.93 12.84 3 21853 51564 42547915
Ulcer 16.52 12.84 30 21826 16411 42583068
Blood glucose increased 16.35 12.84 78 21778 73621 42525858
Cataract nuclear 16.20 12.84 8 21848 789 42598690
Benign prostatic hyperplasia 15.81 12.84 34 21822 21018 42578461
Carotid bruit 15.28 12.84 5 21851 167 42599312
End stage renal disease 15.12 12.84 29 21827 16529 42582950
C-reactive protein increased 14.84 12.84 7 21849 63553 42535926
Atrial fibrillation 14.16 12.84 121 21735 139472 42460007
Flatulence 13.86 12.84 36 21820 25116 42574363
Intentional product use issue 13.81 12.84 10 21846 71823 42527656
Bacteroides infection 13.60 12.84 11 21845 2576 42596903
Upper respiratory tract infection 13.55 12.84 50 21806 42123 42557356
Dilatation atrial 13.05 12.84 10 21846 2165 42597314

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 124.36 10.49 51 59228 480504 110049516
Electric shock 113.08 10.49 41 59238 1787 110528233
Blood uric acid increased 110.58 10.49 92 59187 21437 110508583
Therapy cessation 89.09 10.49 115 59164 44742 110485278
Appendicolith 86.14 10.49 67 59212 14188 110515832
Blood phosphorus increased 84.28 10.49 70 59209 16270 110513750
Hyperlipidaemia 80.93 10.49 98 59181 35750 110494270
Completed suicide 78.46 10.49 17 59262 242364 110287656
Hand deformity 77.88 10.49 12 59267 218494 110311526
Constipation 76.80 10.49 387 58892 357399 110172621
Drug interaction 75.85 10.49 94 59185 500089 110029931
Treatment failure 75.68 10.49 27 59252 277207 110252813
Post-traumatic stress disorder 75.58 10.49 46 59233 6550 110523470
Infective pulmonary exacerbation of cystic fibrosis 73.54 10.49 62 59217 14709 110515311
Intervertebral discitis 73.12 10.49 46 59233 6944 110523076
Post cholecystectomy syndrome 67.60 10.49 23 59256 829 110529191
Temperature intolerance 66.27 10.49 57 59222 13893 110516127
Multiple sclerosis 65.91 10.49 75 59204 25623 110504397
Coronary artery disease 65.72 10.49 129 59150 71561 110458459
Vitamin B12 increased 63.70 10.49 28 59251 2027 110527993
Off label use 63.57 10.49 508 58771 1499677 109030343
Acute kidney injury 62.30 10.49 157 59122 635273 109894747
Back pain 61.36 10.49 374 58905 370622 110159398
Chronic sinusitis 60.62 10.49 71 59208 25013 110505007
Myasthenia gravis 58.97 10.49 65 59214 21446 110508574
Stress 58.06 10.49 155 59124 105193 110424827
Low turnover osteopathy 57.71 10.49 26 59253 1996 110528024
Macular degeneration 56.88 10.49 64 59215 21595 110508425
Appendicitis 56.56 10.49 73 59206 28391 110501629
Febrile neutropenia 56.38 10.49 52 59227 316715 110213305
Radiculopathy 55.74 10.49 60 59219 19276 110510744
Glomerular filtration rate increased 55.48 10.49 25 59254 1920 110528100
Systemic lupus erythematosus 55.20 10.49 34 59245 254304 110275716
Hypocholesterolaemia 54.32 10.49 37 59242 6384 110523636
C-reactive protein abnormal 54.14 10.49 4 59275 129691 110400329
Pemphigus 53.48 10.49 24 59255 214546 110315474
Vaginal flatulence 52.44 10.49 47 59232 12097 110517923
Demyelination 52.00 10.49 42 59237 9387 110520633
Muscle spasticity 51.82 10.49 79 59200 35836 110494184
Drug ineffective 51.74 10.49 544 58735 1519996 109010024
Duodenal ulcer perforation 50.76 10.49 16 59263 177684 110352336
Blood immunoglobulin A increased 50.67 10.49 22 59257 1546 110528474
Intentional overdose 50.23 10.49 6 59273 132495 110397525
Rheumatoid factor positive 49.81 10.49 6 59273 131634 110398386
Maternal exposure during pregnancy 48.81 10.49 39 59240 254844 110275176
Granulocyte count increased 48.78 10.49 23 59256 1960 110528060
Hyperphosphataemia 47.52 10.49 51 59228 16330 110513690
Female genital tract fistula 47.17 10.49 51 59228 16468 110513552
Ulcer 46.26 10.49 83 59196 43033 110486987
Proctitis 46.14 10.49 51 59228 16876 110513144
Depression 45.72 10.49 309 58970 317026 110212994
Rheumatic fever 45.38 10.49 6 59273 122573 110407447
Intervertebral disc degeneration 45.06 10.49 52 59227 18033 110511987
Vaginal discharge 43.79 10.49 51 59228 17857 110512163
Rheumatoid factor increased 43.69 10.49 23 59256 2482 110527538
Analgesic therapy 43.50 10.49 34 59245 7250 110522770
Synovitis 43.11 10.49 50 59229 274042 110255978
Blood test abnormal 42.89 10.49 64 59215 28490 110501530
Aspartate aminotransferase 42.82 10.49 17 59262 952 110529068
Intentional product use issue 42.58 10.49 42 59237 247864 110282156
Weight decreased 42.47 10.49 410 58869 467647 110062373
Drug therapy 41.32 10.49 33 59246 7258 110522762
Ventricular fibrillation 39.89 10.49 76 59203 41237 110488783
Neutropenia 39.49 10.49 89 59190 374531 110155489
Myelosuppression 39.11 10.49 3 59276 94337 110435683
Thrombosis 38.48 10.49 137 59142 108525 110421495
Blood cholesterol increased 37.58 10.49 197 59082 184588 110345432
Joint noise 37.37 10.49 27 59252 5116 110524904
Helicobacter infection 37.17 10.49 26 59253 181851 110348169
Neuralgia 37.10 10.49 81 59198 48397 110481623
Sleep disorder therapy 36.45 10.49 31 59248 7440 110522580
Paraesthesia oral 36.35 10.49 65 59214 33606 110496414
Incorrect route of product administration 36.04 10.49 95 59184 63966 110466054
Dry mouth 35.86 10.49 206 59073 199742 110330278
Gastrooesophageal reflux disease 35.32 10.49 190 59089 179786 110350234
Overdose 35.32 10.49 44 59235 233750 110296270
Iron deficiency 34.56 10.49 46 59233 18430 110511590
Vitamin D deficiency 34.41 10.49 46 59233 18506 110511514
Interstitial lung disease 34.07 10.49 16 59263 139318 110390702
Swollen joint count increased 33.75 10.49 3 59276 83658 110446362
Femur fracture 33.69 10.49 74 59205 44395 110485625
Ear pain 33.13 10.49 82 59197 53144 110476876
Dactylitis 33.04 10.49 23 59256 4110 110525910
Coordination abnormal 32.93 10.49 53 59226 25175 110504845
Diverticulum 32.71 10.49 41 59238 15485 110514535
Blood calcium increased 32.35 10.49 44 59235 17996 110512024
Suicide attempt 31.96 10.49 8 59271 103386 110426634
Procedural pain 31.39 10.49 63 59216 35502 110494518
Cardiogenic shock 31.21 10.49 84 59195 57254 110472766
Bronchitis 30.96 10.49 166 59113 156866 110373154
Cardiac failure 30.84 10.49 33 59246 187593 110342427
Balance disorder 30.77 10.49 134 59145 116426 110413594
Drug reaction with eosinophilia and systemic symptoms 30.43 10.49 4 59275 82091 110447929
Throat clearing 29.79 10.49 22 59257 4311 110525709
Spinal disorder 29.68 10.49 34 59245 11694 110518326
Headache 29.57 10.49 649 58630 881728 109648292
Pericarditis 29.32 10.49 45 59234 219069 110310951
Progressive multifocal leukoencephalopathy 29.31 10.49 50 59229 24906 110505114
Activated partial thromboplastin time prolonged 29.21 10.49 47 59232 22321 110507699
Asthenia 29.19 10.49 525 58754 688474 109841546
Pancytopenia 29.07 10.49 42 59237 209571 110320449
Chronic obstructive pulmonary disease 28.44 10.49 125 59154 109033 110420987
Hypophosphataemia 28.36 10.49 58 59221 33124 110496896
Therapeutic product effect decreased 28.29 10.49 55 59224 244261 110285759
Product complaint 28.02 10.49 36 59243 13936 110516084
Wound 27.83 10.49 52 59227 234385 110295635
Anticoagulant therapy 27.72 10.49 23 59256 5338 110524682
Muscle spasms 27.37 10.49 248 59031 277909 110252111
Antacid therapy 27.26 10.49 23 59256 5461 110524559
Flatulence 26.99 10.49 75 59204 52074 110477946
Vitamin B12 deficiency 26.90 10.49 30 59249 10025 110519995
Oral candidiasis 26.85 10.49 68 59211 44692 110485328
Product use issue 26.78 10.49 82 59197 311613 110218407
Red blood cell count decreased 26.75 10.49 87 59192 65836 110464184
Dry eye 25.75 10.49 77 59202 55716 110474304
Blood triglycerides increased 25.59 10.49 46 59233 23880 110506140
Abdominal distension 25.49 10.49 171 59108 174932 110355088
Diabetes mellitus 25.28 10.49 113 59166 99268 110430752
Aspartate aminotransferase increased 24.99 10.49 159 59120 159777 110370243
Angina unstable 24.92 10.49 37 59242 16395 110513625
Blood glucose decreased 24.56 10.49 51 59228 29437 110500583
Contraindicated product administered 24.54 10.49 61 59218 248206 110281814
Thrombocytopenia 24.48 10.49 100 59179 348785 110181235
Depressed mood 24.44 10.49 80 59199 60729 110469291
Malignant neoplasm progression 24.18 10.49 35 59244 174532 110355488
Ventricular hypertrophy 24.16 10.49 24 59255 7021 110522999
Lumbar spinal stenosis 24.10 10.49 23 59256 6410 110523610
Drug intolerance 24.07 10.49 124 59155 406388 110123632
Throat irritation 23.86 10.49 73 59206 53479 110476541
Hepatic function abnormal 23.84 10.49 9 59270 89286 110440734
Transient ischaemic attack 23.79 10.49 82 59197 63900 110466120
Oral pain 23.63 10.49 58 59221 37386 110492634
Glycosylated haemoglobin increased 23.48 10.49 44 59235 23575 110506445
Spinal osteoarthritis 23.13 10.49 40 59239 20143 110509877
White blood cells urine positive 22.84 10.49 24 59255 7500 110522520
Respiratory disorder 22.75 10.49 87 59192 71295 110458725
Carotid bruit 22.71 10.49 10 59269 727 110529293
Mitral valve incompetence 22.51 10.49 53 59226 33276 110496744
Dizziness 22.24 10.49 510 58769 697683 109832337
Metabolic acidosis 22.10 10.49 13 59266 99731 110430289
Liver injury 22.00 10.49 29 59250 150384 110379636
C-reactive protein increased 21.96 10.49 53 59226 217866 110312154
Cholecystitis acute 21.76 10.49 34 59245 15748 110514272
Sleep disorder due to general medical condition, insomnia type 21.72 10.49 15 59264 105628 110424392
Renal impairment 21.32 10.49 43 59236 188402 110341618
Dental caries 21.17 10.49 30 59249 12743 110517277
Anti-cyclic citrullinated peptide antibody positive 21.04 10.49 41 59238 181943 110348077
Fall 20.85 10.49 446 58833 603036 109926984
Glossodynia 20.82 10.49 56 59223 221948 110308072
Bacterial infection 20.74 10.49 63 59216 45973 110484047
Toxic epidermal necrolysis 20.47 10.49 3 59276 56724 110473296
Neuropathy peripheral 20.33 10.49 165 59114 179112 110350908
Ascites 20.29 10.49 101 59178 92707 110437313
Rotator cuff syndrome 20.19 10.49 34 59245 16760 110513260
Spinal epidural haematoma 19.69 10.49 12 59267 1713 110528307
Discomfort 19.51 10.49 55 59224 214652 110315368
Benign prostatic hyperplasia 19.43 10.49 35 59244 18199 110511821
Fatigue 19.37 10.49 816 58463 1215142 109314878
Cystocele 19.32 10.49 10 59269 1042 110528978
Ill-defined disorder 19.32 10.49 34 59245 156819 110373201
Mobility decreased 19.31 10.49 64 59215 237358 110292662
Low density lipoprotein increased 19.10 10.49 26 59253 10640 110519380
Spondylolisthesis 19.02 10.49 16 59263 3782 110526238
Abdominal pain upper 18.84 10.49 277 59002 348834 110181186
Monocyte count increased 18.84 10.49 29 59250 13264 110516756
Aspartate aminotransferase abnormal 18.74 10.49 15 59264 3310 110526710
Blood pressure systolic decreased 18.59 10.49 29 59250 13412 110516608
Anaemia postoperative 18.50 10.49 12 59267 1909 110528111
Cataract 18.45 10.49 88 59191 79397 110450623
Product dose omission issue 18.43 10.49 258 59021 321524 110208496
Stress urinary incontinence 18.43 10.49 12 59267 1921 110528099
Night sweats 18.40 10.49 129 59150 133854 110396166
Fracture nonunion 18.35 10.49 11 59268 1523 110528497
Muscle strain 18.11 10.49 26 59253 11176 110518844
Nausea 17.85 10.49 821 58458 1234869 109295151
Aortic stenosis 17.82 10.49 28 59251 13031 110516989
Body height decreased 17.79 10.49 25 59254 10538 110519482
Septic shock 17.77 10.49 36 59243 157492 110372528
Intervertebral disc protrusion 17.58 10.49 43 59236 27655 110502365
Blood alkaline phosphatase increased 17.55 10.49 80 59199 70855 110459165
Cytokine release syndrome 17.30 10.49 8 59271 70298 110459722
Cardio-respiratory arrest 17.28 10.49 22 59257 115814 110414206
Body temperature increased 16.87 10.49 66 59213 54647 110475373
Agranulocytosis 16.86 10.49 6 59273 61754 110468266
Arthropathy 16.84 10.49 88 59191 287434 110242586
Distal intestinal obstruction syndrome 16.72 10.49 9 59270 1016 110529004
Drug-induced liver injury 16.70 10.49 24 59255 120043 110409977
Diarrhoea 16.43 10.49 757 58522 1138748 109391272
Laryngeal pain 16.28 10.49 18 59261 5957 110524063
Alanine aminotransferase increased 16.15 10.49 160 59119 183613 110346407
Fibromyalgia 16.11 10.49 43 59236 170866 110359154
Fractional exhaled nitric oxide increased 16.07 10.49 8 59271 768 110529252
Myalgia 16.00 10.49 186 59093 222195 110307825
Hypersensitivity 15.98 10.49 139 59140 403859 110126161
Gingival disorder 15.84 10.49 15 59264 4138 110525882
Myocardial infarction 15.81 10.49 165 59114 191918 110338102
Pyrexia 15.79 10.49 364 58915 897901 109632119
Serotonin syndrome 15.72 10.49 6 59273 59147 110470873
Product use in unapproved indication 15.52 10.49 159 59120 447218 110082802
Frequent bowel movements 15.12 10.49 77 59202 71313 110458707
Stress fracture 15.10 10.49 19 59260 7202 110522818
Plantar fasciitis 15.00 10.49 16 59263 5085 110524935
Benign vulval neoplasm 14.89 10.49 4 59275 63 110529957
Cholestasis 14.88 10.49 8 59271 64510 110465510
Facet joint syndrome 14.85 10.49 18 59261 96810 110433210
Feeling abnormal 14.76 10.49 155 59124 180556 110349464
Renal cyst 14.63 10.49 31 59248 18141 110511879
Gout 14.60 10.49 48 59231 36518 110493502
Delusional disorder, persecutory type 14.52 10.49 7 59272 627 110529393
Lactic acidosis 14.50 10.49 17 59262 92794 110437226
Dermatitis atopic 14.49 10.49 38 59241 25503 110504517
Haemorrhoids 14.40 10.49 47 59232 35625 110494395
End stage renal disease 14.34 10.49 34 59245 21439 110508581
Limb asymmetry 14.27 10.49 7 59272 651 110529369
Carpal tunnel syndrome 14.24 10.49 35 59244 22575 110507445
Confusional state 14.12 10.49 172 59107 468508 110061512
Pain 14.09 10.49 636 58643 954319 109575701
Cataract nuclear 14.08 10.49 9 59270 1397 110528623
Death 14.07 10.49 277 59002 698592 109831428
Lip dry 13.92 10.49 20 59259 100063 110429957
Bladder prolapse 13.87 10.49 9 59270 1433 110528587
Dry skin 13.82 10.49 102 59177 107551 110422469
Rubber sensitivity 13.82 10.49 11 59268 2407 110527613
Pneumocystis jirovecii pneumonia 13.81 10.49 3 59276 42732 110487288
Therapy non-responder 13.77 10.49 41 59238 157266 110372754
Nasal congestion 13.71 10.49 95 59184 98187 110431833
Blood urea increased 13.61 10.49 62 59217 54895 110475125
Bone erosion 13.55 10.49 4 59275 46367 110483653
Bone loss 13.54 10.49 12 59267 3043 110526977
Cardiac failure congestive 13.52 10.49 132 59147 150868 110379152
Haematochezia 13.46 10.49 107 59172 115417 110414603
Cough 13.39 10.49 333 58946 461308 110068712
Breast fibrosis 13.37 10.49 3 59276 21 110529999
Grip strength decreased 13.28 10.49 14 59265 80160 110449860
General physical health deterioration 13.22 10.49 155 59124 425140 110104880
Hypoglycaemia unawareness 12.93 10.49 5 59274 261 110529759
Cervicobrachial syndrome 12.86 10.49 8 59271 1184 110528836
Coronary artery occlusion 12.81 10.49 27 59252 15745 110514275
Cardiac arrest 12.80 10.49 58 59221 196695 110333325
Troponin increased 12.72 10.49 40 59239 29726 110500294
Hot flush 12.46 10.49 69 59210 65967 110464053
Adjustment disorder with depressed mood 12.44 10.49 4 59275 43879 110486141
Exposure during pregnancy 12.36 10.49 47 59232 167377 110362643
Pulmonary function test decreased 12.35 10.49 19 59260 8681 110521339
Rash maculo-papular 12.25 10.49 13 59266 74209 110455811
Burning sensation 12.19 10.49 71 59208 69141 110460879
Epilepsy 12.09 10.49 22 59257 100187 110429833
Influenza like illness 12.06 10.49 85 59194 88327 110441693
Bacteroides infection 12.02 10.49 11 59268 2908 110527112
Dementia Alzheimer's type 12 10.49 7 59272 922 110529098
Blood glucose increased 11.95 10.49 116 59163 132380 110397640
Medication error 11.95 10.49 24 59255 105342 110424678
Periorbital haemorrhage 11.89 10.49 5 59274 325 110529695
Drug eruption 11.88 10.49 7 59272 53652 110476368
Urinary tract infection 11.85 10.49 243 59036 326039 110203981
Mucosal inflammation 11.69 10.49 21 59258 96120 110433900
Injury 11.69 10.49 52 59227 177213 110352807
Bone pain 11.59 10.49 67 59212 65066 110464954
Osteopenia 11.55 10.49 32 59247 22177 110507843
Deep vein thrombosis postoperative 11.43 10.49 9 59270 59282 110470738
Muscle injury 11.41 10.49 38 59241 140769 110389251
Ligament sprain 11.34 10.49 26 59253 16042 110513978
Toothache 11.32 10.49 33 59246 23542 110506478
Delirium 11.25 10.49 36 59243 134989 110395031
Dilatation atrial 11.18 10.49 12 59267 3840 110526180
Peripheral vascular disorder 11.17 10.49 18 59261 8558 110521462
Cystic fibrosis lung 11.06 10.49 4 59275 173 110529847
Traumatic arthritis 11.01 10.49 3 59276 50 110529970
Arthralgia 11 10.49 517 58762 779115 109750905
Neutrophil count decreased 10.97 10.49 31 59248 120910 110409110
Scoliosis 10.93 10.49 18 59261 8715 110521305
Wheezing 10.91 10.49 86 59193 255144 110274876
Cyst 10.89 10.49 26 59253 16470 110513550
Cystic fibrosis 10.78 10.49 13 59266 4718 110525302
Lacunar infarction 10.77 10.49 15 59264 6271 110523749
Total lung capacity decreased 10.76 10.49 16 59263 7098 110522922
Exostosis 10.75 10.49 51 59228 45905 110484115
Back disorder 10.74 10.49 30 59249 20892 110509128
Lung neoplasm 10.58 10.49 17 59262 8059 110521961
Shock 10.50 10.49 8 59271 53580 110476440

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC B05XB03 BLOOD AND BLOOD FORMING ORGANS
BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
I.V. SOLUTION ADDITIVES
Amino acids
ATC V03AF11 VARIOUS
ALL OTHER THERAPEUTIC PRODUCTS
ALL OTHER THERAPEUTIC PRODUCTS
Detoxifying agents for antineoplastic treatment
CHEBI has role CHEBI:27027 micronutrient
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:50733 nutraceutical
CHEBI has role CHEBI:75771 mouse metabolite
CHEBI has role CHEBI:75772 <em>Saccharomyces cerevisiae </em> metabolite
CHEBI has role CHEBI:76924 plant metabolite
CHEBI has role CHEBI:76971 <em>Escherichia coli</em> metabolite
CHEBI has role CHEBI:77746 human metabolite
CHEBI has role CHEBI:84735 algal metabolite
CHEBI has role CHEBI:83056 <em>Daphnia magna</em> metabolite

Related Drugs by ATC class:

B05XB Amino acids 2 drugs
alanyl glutaminearginine
V03AF Detoxifying agents for antineoplastic treatment 10 drugs
amifostineargininedexrazoxaneglucarpidaseleucovorinlevofolinic acidmesnapaliferminrasburicasetrilaciclib

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Renal radiation exposure from Lutetium (177Lu) oxodotreotide indication 218190002
Partial Central Diabetes Insipidus indication
Classical phenylketonuria contraindication 7573000
Poisoning by digitalis glycoside contraindication 12876009
Sarcoidosis contraindication 31541009 DOID:11335
End stage renal disease contraindication 46177005 DOID:784
Humoral hypercalcemia of malignancy contraindication 47709007
Heart disease contraindication 56265001 DOID:114
Hypercalcemia contraindication 66931009 DOID:12678
Ventricular fibrillation contraindication 71908006
Hypercalciuria contraindication 71938000
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.99 acidic
pKa2 10.46 Basic
pKa3 9.86 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Glutathione reductase, mitochondrial Enzyme Ki 4.26 CHEMBL

External reference:

IDSource
4018682 VUID
N0000146993 NUI
D02304 KEGG_DRUG
657-27-2 SECONDARY_CAS_RN
4018682 VANDF
4018689 VANDF
C0024337 UMLSCUI
CHEBI:25094 CHEBI
LYS PDB_CHEM_ID
CHEMBL8085 ChEMBL_ID
DB00123 DRUGBANK_ID
CHEMBL2105886 ChEMBL_ID
D008239 MESH_DESCRIPTOR_UI
5962 PUBCHEM_CID
6166 INN_ID
K3Z4F929H6 UNII
6536 RXNORM
10705 MMSL
233693 MMSL
40036 MMSL
42619 MMSL
5002 MMSL
d00488 MMSL
000931 NDDF
005151 NDDF
418834008 SNOMEDCT_US
734658000 SNOMEDCT_US
75799006 SNOMEDCT_US
724 IUPHAR_LIGAND_ID
K3Z4F929H6 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-0180 INJECTION 464 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-0184 INJECTION 464 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-0188 INJECTION 464 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-0194 INJECTION 464 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-0198 INJECTION 348 mg INTRAVENOUS NDA 21 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 20 0338-0202 INJECTION 464 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 20 0338-0206 INJECTION 464 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 20 0338-0210 INJECTION 464 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 20 0338-0214 INJECTION 464 mg INTRAVENOUS NDA 20 sections
Travasol HUMAN PRESCRIPTION DRUG LABEL 15 0338-0644 INJECTION 580 mg INTRAVENOUS NDA 20 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1089 INJECTION 247 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1091 INJECTION 247 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1099 INJECTION 290 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1101 INJECTION 290 mg INTRAVENOUS NDA 21 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1113 INJECTION 247 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1115 INJECTION 247 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1123 INJECTION 290 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1125 INJECTION 290 mg INTRAVENOUS NDA 20 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1133 INJECTION 247 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1134 INJECTION 247 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1137 INJECTION 290 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-1138 INJECTION 290 mg INTRAVENOUS NDA 21 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1142 INJECTION 159 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1144 INJECTION 247 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1145 INJECTION 247 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1147 INJECTION 290 mg INTRAVENOUS NDA 20 sections
CLINIMIX E HUMAN PRESCRIPTION DRUG LABEL 21 0338-1148 INJECTION 290 mg INTRAVENOUS NDA 20 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-7001 INJECTION 247 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-7003 INJECTION 247 mg INTRAVENOUS NDA 21 sections
CLINIMIX HUMAN PRESCRIPTION DRUG LABEL 16 0338-7005 INJECTION 247 mg INTRAVENOUS NDA 21 sections