linezolid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
oxazolidinone antibacterials 1584 165800-03-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • linezolid
  • linospan
  • linox
  • zyvox
  • zyvoxid
  • linezolid sodium chloride
  • linezolide
  • U-100766
  • U 100766
An oxazolidinone and acetamide derived ANTI-BACTERIAL AGENT and PROTEIN SYNTHESIS INHIBITOR that is used in the treatment of GRAM-POSITIVE BACTERIAL INFECTIONS of the skin and respiratory tract.
  • Molecular weight: 337.35
  • Formula: C16H20FN3O4
  • CLOGP: 0.42
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 71.11
  • ALOGS: -2.37
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.20 g O
1.20 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 8 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 30 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 50.82 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.58 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.69 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.50 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.596 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 2.393 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 30.409 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 1.288 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 74.520 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 85.220 % High 1
herg hERG pIC50 4.295 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 0.959 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 2.965 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 82.150 % High 1
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP3K21,MAPK7,MTOR,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKCD,PRKDC,SIK2,SIK3,STK33,TEK 28
kinase-selectivity-class BRAF,GRK2 2
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 3.819 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 4.920 High 1
mh-clint Mouse hepatocyte intrinsic clearance 2.018 High 1
mppb Mouse plasma protein binding (% unbound) 78.050 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 15.596 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 84.240 % High 1
rat-kpuu-brain Rat brain Kpuu 0.077 % High 1
rh-clint Rat hepatocyte intrinsic clearance 1.422 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 91.300 % High 1
rppb Rat plasma protein binding (% unbound) 76.100 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 941.890 uM High 1

Approvals:

DateAgencyCompanyOrphan
April 18, 2000 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Lactic acidosis 1087.72 17.27 475 32791 49988 90545193
Thrombocytopenia 1005.53 17.27 733 32533 207992 90387189
Serotonin syndrome 752.74 17.27 337 32929 37550 90557631
Drug resistance 715.96 17.27 305 32961 30144 90565037
Anaemia 511.21 17.27 637 32629 352165 90243016
Pathogen resistance 410.01 17.27 142 33124 7973 90587208
Pancytopenia 389.36 17.27 335 32931 119928 90475253
Neuropathy peripheral 369.13 17.27 344 32922 136626 90458555
Drug interaction 337.15 17.27 459 32807 275994 90319187
Multiple organ dysfunction syndrome 325.54 17.27 239 33027 68097 90527084
Electrocardiogram QT prolonged 286.94 17.27 227 33039 72229 90522952
Septic shock 253.22 17.27 225 33041 83935 90511246
Platelet count decreased 250.18 17.27 279 32987 136690 90458491
Off label use 245.27 17.27 921 32345 1101331 89493850
Drug reaction with eosinophilia and systemic symptoms 215.95 17.27 155 33111 42603 90552578
Myelosuppression 201.66 17.27 163 33103 53428 90541753
Acute kidney injury 195.07 17.27 389 32877 319998 90275183
Optic neuropathy 187.29 17.27 60 33206 2638 90592543
Mitochondrial toxicity 179.77 17.27 43 33223 620 90594561
Pain 174.77 17.27 74 33192 996267 89598914
Fatigue 165.42 17.27 111 33155 1153912 89441269
Respiratory failure 150.64 17.27 201 33065 118217 90476964
Hyperlactacidaemia 147.60 17.27 56 33210 4080 90591101
Ototoxicity 137.65 17.27 44 33222 1920 90593261
Nasopharyngitis 135.03 17.27 3 33263 407101 90188080
Hypertransaminasaemia 130.48 17.27 78 33188 15747 90579434
Optic neuritis 121.76 17.27 63 33203 9615 90585566
Eosinophilia 120.67 17.27 93 33173 28440 90566741
Joint swelling 118.48 17.27 21 33245 503279 90091902
Sepsis 117.33 17.27 225 33041 179589 90415592
Arthropathy 116.63 17.27 4 33262 366238 90228943
Infusion related reaction 116.01 17.27 10 33256 416770 90178411
Alopecia 115.79 17.27 21 33245 495050 90100131
Metabolic acidosis 111.24 17.27 119 33147 55557 90539624
Toxic optic neuropathy 109.32 17.27 24 33242 230 90594951
Hepatic cytolysis 107.81 17.27 90 33176 30826 90564355
Swelling 104.19 17.27 15 33251 419043 90176138
Synovitis 103.61 17.27 4 33262 329748 90265433
Bicytopenia 102.74 17.27 42 33224 3729 90591452
Bone marrow failure 102.54 17.27 89 33177 32132 90563049
Clostridium difficile colitis 102.05 17.27 82 33184 26624 90568557
Mycobacterium abscessus infection 100.34 17.27 30 33236 1045 90594136
Pemphigus 99.29 17.27 5 33261 326859 90268322
Renal failure 96.81 17.27 173 33093 130834 90464347
Aspergillus infection 96.18 17.27 56 33210 10767 90584414
Hepatotoxicity 95.15 17.27 100 33166 45742 90549439
Arthralgia 94.71 17.27 88 33178 778434 89816747
Staphylococcal infection 92.33 17.27 101 33165 48338 90546843
Polyneuropathy 90.55 17.27 67 33199 19274 90575907
Therapeutic product effect decreased 88.46 17.27 3 33263 277568 90317613
Systemic lupus erythematosus 87.55 17.27 14 33252 361882 90233299
Skin candida 86.12 17.27 30 33236 1711 90593470
Trichoglossia 85.17 17.27 22 33244 441 90594740
Acute generalised exanthematous pustulosis 84.03 17.27 56 33210 13647 90581534
Sinusitis 83.61 17.27 13 33253 343075 90252106
Rheumatoid arthritis 83.41 17.27 16 33250 362598 90232583
Tongue discolouration 82.04 17.27 35 33231 3458 90591723
Glossodynia 81.17 17.27 11 33255 321768 90273413
Leukopenia 80.90 17.27 138 33128 100572 90494609
Pericarditis 79.36 17.27 5 33261 270146 90325035
Paradoxical drug reaction 76.78 17.27 39 33227 5727 90589454
Tooth discolouration 76.46 17.27 25 33241 1173 90594008
Pancreatitis acute 73.78 17.27 74 33192 32041 90563140
Cholestasis 73.23 17.27 78 33188 36221 90558960
Weight increased 73.06 17.27 31 33235 417896 90177285
Peripheral swelling 71.64 17.27 31 33235 413075 90182106
Headache 70.57 17.27 131 33135 862615 89732566
Wound 70.45 17.27 13 33253 302967 90292214
Discomfort 70.09 17.27 9 33257 274326 90320855
Dysbiosis 67.87 17.27 25 33241 1677 90593504
Candida infection 64.87 17.27 71 33195 33986 90561195
Pain in extremity 64.68 17.27 43 33223 450486 90144695
Mobility decreased 64.60 17.27 8 33258 250726 90344455
Enterococcal infection 64.10 17.27 42 33224 9949 90585232
Impaired healing 64.09 17.27 6 33260 234193 90360988
Drug ineffective for unapproved indication 63.95 17.27 99 33167 66545 90528636
Toxic leukoencephalopathy 63.46 17.27 20 33246 833 90594348
Musculoskeletal stiffness 60.41 17.27 17 33249 296515 90298666
Contusion 60.10 17.27 10 33256 251206 90343975
Neutropenia 59.74 17.27 200 33066 224704 90370477
Product dose omission issue 58.91 17.27 17 33249 291670 90303511
Hepatocellular injury 58.01 17.27 62 33204 28896 90566285
Geotrichum infection 56.67 17.27 17 33249 599 90594582
Rash maculo-papular 55.90 17.27 72 33194 40861 90554320
Posterior reversible encephalopathy syndrome 54.14 17.27 53 33213 22286 90572895
Blood lactic acid increased 54.12 17.27 36 33230 8742 90586439
Wheezing 53.68 17.27 11 33255 238069 90357112
Abdominal discomfort 53.29 17.27 58 33208 477270 90117911
Contraindicated product administered 52.42 17.27 26 33240 320113 90275068
Haemophagocytic lymphohistiocytosis 51.82 17.27 44 33222 15415 90579766
Toxicity to various agents 51.71 17.27 226 33040 287620 90307561
Papillitis 51.54 17.27 10 33256 48 90595133
Disseminated intravascular coagulation 50.15 17.27 50 33216 21488 90573693
Ill-defined disorder 49.89 17.27 5 33261 184886 90410295
Pseudomonas infection 49.19 17.27 42 33224 14823 90580358
Lower respiratory tract infection 48.11 17.27 16 33250 250643 90344538
Pancreatitis haemorrhagic 47.38 17.27 15 33251 634 90594547
Injury 46.88 17.27 8 33258 197341 90397840
Memory impairment 46.84 17.27 8 33258 197236 90397945
Migraine 46.84 17.27 7 33259 190385 90404796
Immune reconstitution inflammatory syndrome associated tuberculosis 46.79 17.27 14 33252 489 90594692
Blood creatine phosphokinase increased 46.70 17.27 60 33206 33963 90561218
Aplasia pure red cell 46.48 17.27 27 33239 5167 90590014
Nervous system disorder 46.40 17.27 48 33218 21545 90573636
Injection site pain 46.08 17.27 5 33261 173694 90421487
Multiple-drug resistance 45.81 17.27 31 33235 7745 90587436
Muscle spasms 45.09 17.27 18 33248 251865 90343316
Hyponatraemia 44.94 17.27 129 33137 133409 90461772
Hallucination 44.76 17.27 84 33182 65875 90529306
Klebsiella infection 44.48 17.27 34 33232 10263 90584918
Drug level below therapeutic 43.66 17.27 27 33239 5787 90589394
Hyperbilirubinaemia 43.34 17.27 38 33228 13898 90581283
Encephalopathy 43.16 17.27 68 33198 46376 90548805
Shock 43.08 17.27 53 33213 28725 90566456
Hypomagnesaemia 43.05 17.27 59 33207 35529 90559652
Disseminated tuberculosis 43.01 17.27 22 33244 3277 90591904
Hypoglycaemia 42.57 17.27 85 33181 69763 90525418
Hepatic infarction 42.51 17.27 14 33252 672 90594509
Drug level decreased 41.75 17.27 32 33234 9698 90585483
Renal impairment 41.62 17.27 108 33158 105313 90489868
Cough decreased 41.46 17.27 6 33260 0 90595181
Blister 41.29 17.27 21 33245 254977 90340204
Fall 41.23 17.27 71 33195 481739 90113442
Acute hepatic failure 41.18 17.27 46 33220 22515 90572666
Malaise 40.26 17.27 98 33168 585888 90009293
Psoriasis 39.84 17.27 4 33262 147750 90447431
Systemic candida 39.73 17.27 24 33242 4935 90590246
Hypokalaemia 39.69 17.27 122 33144 130994 90464187
Transaminases increased 39.58 17.27 58 33208 37134 90558047
Hepatic failure 39.49 17.27 60 33206 39668 90555513
Drug ineffective 39.40 17.27 719 32547 1383579 89211602
Toxic skin eruption 39.30 17.27 38 33228 15736 90579445
Maternal exposure during pregnancy 38.80 17.27 45 33221 360018 90235163
Haematotoxicity 38.62 17.27 34 33232 12501 90582680
Acute respiratory distress syndrome 38.45 17.27 50 33216 28636 90566545
Pneumothorax 38.32 17.27 41 33225 19126 90576055
Diabetic macroangiopathy 38.00 17.27 9 33257 124 90595057
Sleep disorder 37.37 17.27 13 33253 198017 90397164
Mediastinal effusion 37.19 17.27 8 33258 69 90595112
Hypersensitivity 37.09 17.27 69 33197 454608 90140573
Product use in unapproved indication 36.77 17.27 230 33036 336006 90259175
Cystic fibrosis 36.63 17.27 21 33245 3920 90591261
Oedematous kidney 36.58 17.27 9 33257 147 90595034
Bacteraemia 36.53 17.27 43 33223 22257 90572924
Aplasia 36.39 17.27 21 33245 3970 90591211
Respiratory distress 36.16 17.27 57 33209 38889 90556292
Infective pulmonary exacerbation of cystic fibrosis 35.98 17.27 30 33236 10249 90584932
Hypertension 35.96 17.27 71 33195 457461 90137720
Vomiting 35.83 17.27 444 32822 787849 89807332
Meningitis tuberculous 35.11 17.27 12 33254 646 90594535
Asthma 34.86 17.27 23 33243 242137 90353044
Stomatitis 34.54 17.27 30 33236 274668 90320513
Musculoskeletal pain 34.52 17.27 10 33256 171241 90423940
Blood disorder 34.26 17.27 26 33240 7764 90587417
Antibiotic level above therapeutic 34.26 17.27 11 33255 487 90594694
Hepatic enzyme increased 33.82 17.27 50 33216 360686 90234495
Rash morbilliform 33.57 17.27 20 33246 4009 90591172
Toxic epidermal necrolysis 33.57 17.27 50 33216 32478 90562703
Bronchopulmonary aspergillosis 33.29 17.27 30 33236 11368 90583813
Nocardiosis 33.10 17.27 17 33249 2553 90592628
Gastrooesophageal reflux disease 33.00 17.27 10 33256 166327 90428854
Haemoglobin decreased 32.82 17.27 132 33134 161824 90433357
Hypotension 32.75 17.27 218 33048 325179 90270002
Delayed graft function 32.55 17.27 14 33252 1411 90593770
Dermatitis exfoliative generalised 32.24 17.27 22 33244 5571 90589610
Staphylococcal sepsis 32.05 17.27 27 33239 9356 90585825
Back pain 31.68 17.27 42 33224 317133 90278048
Brain abscess 31.66 17.27 17 33249 2795 90592386
Kussmaul respiration 31.07 17.27 9 33257 280 90594901
Agranulocytosis 30.81 17.27 50 33216 34952 90560229
Enterococcal bacteraemia 30.80 17.27 15 33251 2013 90593168
Enterovesical fistula 30.79 17.27 11 33255 676 90594505
Hepatosplenomegaly 30.58 17.27 17 33249 2992 90592189
Osteoarthritis 30.39 17.27 17 33249 195713 90399468
Torticollis 30.31 17.27 16 33250 2542 90592639
Transaminases abnormal 29.94 17.27 11 33255 732 90594449
Raoultella ornithinolytica infection 29.39 17.27 7 33259 99 90595082
Acid base balance abnormal 29.12 17.27 9 33257 351 90594830
Subcutaneous abscess 28.77 17.27 22 33244 6644 90588537
Alternaria infection 28.74 17.27 9 33257 367 90594814
Alanine aminotransferase increased 28.56 17.27 102 33164 118236 90476945
Blood fibrinogen decreased 28.39 17.27 12 33254 1158 90594023
Mixed liver injury 28.26 17.27 23 33243 7600 90587581
Pruritus 28.20 17.27 103 33163 541422 90053759
Band neutrophil count decreased 28.08 17.27 7 33259 121 90595060
Cholecystitis acute 27.96 17.27 25 33241 9379 90585802
Hepatitis cholestatic 27.94 17.27 24 33242 8537 90586644
Neutrophil count decreased 27.94 17.27 73 33193 71459 90523722
Muscular weakness 27.93 17.27 21 33245 206645 90388536
Stevens-Johnson syndrome 27.28 17.27 43 33223 29333 90565848
Disseminated mycobacterium avium complex infection 27.17 17.27 8 33258 264 90594917
Exfoliative rash 27.00 17.27 16 33250 3176 90592005
Nephropathy toxic 26.89 17.27 28 33238 12660 90582521
Insomnia 26.83 17.27 51 33215 333423 90261758
Glomerular filtration rate abnormal 26.79 17.27 12 33254 1333 90593848
Amnesia 26.65 17.27 4 33262 108501 90486680
Myoclonus 26.61 17.27 34 33232 19134 90576047
Road traffic accident 26.36 17.27 4 33262 107622 90487559
Metabolic encephalopathy 26.36 17.27 21 33245 6731 90588450
Pulmonary fibrosis 26.32 17.27 4 33262 107499 90487682
Liver injury 26.21 17.27 15 33251 170552 90424629
Anxiety 26.15 17.27 46 33220 309726 90285455
Inappropriate antidiuretic hormone secretion 26.14 17.27 34 33232 19471 90575710
Seizure 25.98 17.27 118 33148 152511 90442670
Aspartate aminotransferase increased 25.94 17.27 90 33176 102847 90492334
Septal panniculitis 25.87 17.27 6 33260 75 90595106
Oedematous pancreatitis 25.76 17.27 10 33256 775 90594406
Bronchitis 25.65 17.27 12 33254 152915 90442266
Pyrexia 25.38 17.27 361 32905 660124 89935057
Gait inability 25.33 17.27 11 33255 146445 90448736
Product prescribing issue 25.30 17.27 22 33244 7957 90587224
Hyperoxaluria 25.30 17.27 7 33259 184 90594997
Night sweats 25.08 17.27 8 33258 128758 90466423
Escherichia infection 24.97 17.27 30 33236 15865 90579316
Drug level increased 24.90 17.27 40 33226 27722 90567459
Herbal toxicity 24.69 17.27 5 33261 31 90595150
Skin maceration 24.38 17.27 7 33259 211 90594970
Arthritis 23.93 17.27 16 33250 167299 90427882
Mycobacterium chelonae infection 23.82 17.27 9 33257 648 90594533
Electrolyte imbalance 23.79 17.27 36 33230 23709 90571472
Pyelonephritis chronic 23.74 17.27 7 33259 232 90594949
Tuberculosis 23.61 17.27 26 33240 12523 90582658
Wound infection staphylococcal 23.35 17.27 14 33252 2839 90592342
Portal vein cavernous transformation 23.34 17.27 6 33260 118 90595063
Prescribed overdose 23.08 17.27 4 33262 97621 90497560
Cardiac failure acute 22.94 17.27 25 33241 11904 90583277
Coagulopathy 22.90 17.27 35 33231 23254 90571927
Intentional product misuse 22.72 17.27 3 33263 89601 90505580
Drug eruption 22.67 17.27 44 33222 35363 90559818
Serratia infection 22.63 17.27 10 33256 1075 90594106
International normalised ratio increased 22.41 17.27 52 33214 47264 90547917
Neck pain 22.34 17.27 7 33259 113956 90481225
Hepatitis toxic 22.30 17.27 15 33251 3710 90591471
Acinetobacter infection 22.22 17.27 12 33254 1996 90593185
Joint range of motion decreased 22.20 17.27 11 33255 135632 90459549
Neurotoxicity 22.15 17.27 33 33233 21434 90573747
Adrenal cortex necrosis 22.10 17.27 4 33262 12 90595169
Procalcitonin increased 22.06 17.27 11 33255 1553 90593628
Myopathy 22.03 17.27 26 33240 13492 90581689
Pancreatitis 21.14 17.27 65 33201 69761 90525420
Hepatic function abnormal 20.98 17.27 50 33216 46238 90548943
Deafness 20.97 17.27 33 33233 22481 90572700
Lymphadenitis 20.88 17.27 15 33251 4122 90591059
Leuconostoc infection 20.83 17.27 4 33262 18 90595163
Cardiopulmonary failure 20.71 17.27 15 33251 4173 90591008
Tuberculoma of central nervous system 20.70 17.27 7 33259 365 90594816
Inflammation 20.68 17.27 21 33245 178571 90416610
Peripheral sensory neuropathy 20.67 17.27 21 33245 9229 90585952
Osteoporosis 20.66 17.27 5 33261 96526 90498655
Haemoperitoneum 20.63 17.27 14 33252 3514 90591667
Weight decreased 20.59 17.27 71 33195 379839 90215342
Clonus 20.58 17.27 17 33249 5733 90589448
Immune effector cell-associated neurotoxicity syndrome 20.53 17.27 17 33249 5751 90589430
Leukocytosis 20.44 17.27 39 33227 30951 90564230
Pneumonia necrotising 20.38 17.27 8 33258 639 90594542
Therapeutic product effect incomplete 20.05 17.27 25 33241 193871 90401310
Fluid retention 19.99 17.27 4 33262 88087 90507094
Deafness neurosensory 19.97 17.27 18 33248 6823 90588358
Ecthyma 19.96 17.27 7 33259 407 90594774
Infectious pleural effusion 19.91 17.27 11 33255 1914 90593267
Sideroblastic anaemia 19.87 17.27 4 33262 24 90595157
Haemodynamic instability 19.84 17.27 23 33243 11716 90583465
Dysmetria 19.82 17.27 8 33258 687 90594494
Epstein-Barr virus test positive 19.75 17.27 8 33258 693 90594488
Peripheral motor neuropathy 19.65 17.27 11 33255 1962 90593219
Eosinophilic pneumonia acute 19.60 17.27 8 33258 707 90594474
Antimicrobial susceptibility test resistant 19.59 17.27 4 33262 26 90595155
Vascular device infection 19.50 17.27 23 33243 11929 90583252
Anticoagulation drug level above therapeutic 19.40 17.27 11 33255 2011 90593170
Pulmonary haemorrhage 19.39 17.27 19 33247 7994 90587187
Product quality issue 19.31 17.27 3 33263 79322 90515859
Vestibular disorder 19.24 17.27 10 33256 1539 90593642
Live birth 19.24 17.27 3 33263 79104 90516077
Mitochondrial cytopathy 19.17 17.27 6 33260 244 90594937
Long QT syndrome 18.93 17.27 14 33252 4023 90591158
Hypoxia 18.85 17.27 64 33202 72335 90522846
Hyperalbuminaemia 18.76 17.27 4 33262 33 90595148
Mycobacterium avium complex infection 18.74 17.27 14 33252 4084 90591097
Distributive shock 18.63 17.27 13 33253 3411 90591770
Butterfly rash 18.61 17.27 11 33255 2174 90593007
Drug-induced liver injury 18.60 17.27 74 33192 90244 90504937
Respiratory alkalosis 18.55 17.27 13 33253 3435 90591746
Antibiotic level below therapeutic 18.55 17.27 4 33262 35 90595146
Malignant neoplasm progression 18.52 17.27 8 33258 106862 90488319
Chest pain 18.52 17.27 58 33208 319587 90275594
Nasal congestion 18.49 17.27 4 33262 83410 90511771
Wound infection 18.39 17.27 8 33258 106394 90488787
Generalised tonic-clonic seizure 18.36 17.27 40 33226 34863 90560318
Feeling abnormal 17.88 17.27 21 33245 167214 90427967
Mental status changes 17.86 17.27 46 33220 44633 90550548
Mucosal inflammation 17.78 17.27 54 33212 57571 90537610
Differentiation syndrome 17.71 17.27 9 33257 1322 90593859
Necrotising colitis 17.67 17.27 9 33257 1329 90593852
Tuberculin test positive 17.65 17.27 13 33253 3712 90591469
Hallucination, olfactory 17.65 17.27 6 33260 318 90594863
Blood bilirubin increased 17.63 17.27 45 33221 43425 90551756
Influenza like illness 17.59 17.27 4 33262 80607 90514574
Endocarditis 17.46 17.27 17 33249 7096 90588085
Meningitis enterococcal 17.44 17.27 3 33263 6 90595175

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Thrombocytopenia 1239.98 15.53 1196 39990 189083 42391066
Serotonin syndrome 629.59 15.53 361 40825 25484 42554665
Lactic acidosis 521.73 15.53 396 40790 44865 42535284
Electrocardiogram QT prolonged 403.17 15.53 349 40837 47596 42532553
Anaemia 398.27 15.53 851 40335 279427 42300722
Drug resistance 393.08 15.53 299 40887 33949 42546200
Pancytopenia 358.76 15.53 502 40684 117241 42462908
Optic neuropathy 331.26 15.53 115 41071 2397 42577752
Platelet count decreased 273.30 15.53 484 40702 138097 42442052
Off label use 268.54 15.53 1269 39917 637066 41943083
Neuropathy peripheral 253.39 15.53 395 40791 101458 42478691
Drug interaction 224.66 15.53 665 40521 266334 42313815
Drug reaction with eosinophilia and systemic symptoms 202.74 15.53 226 40960 41849 42538300
Pathogen resistance 199.07 15.53 129 41057 11321 42568828
Fatigue 198.17 15.53 87 41099 435554 42144595
Choroiditis 189.24 15.53 65 41121 1310 42578839
Bicytopenia 164.47 15.53 74 41112 3110 42577039
Optic neuritis 151.80 15.53 76 41110 4066 42576083
Hepatotoxicity 149.24 15.53 151 41035 25016 42555133
Enterococcal infection 148.88 15.53 110 41076 11929 42568220
Hyperlactacidaemia 145.59 15.53 76 41110 4440 42575709
Bone marrow failure 139.59 15.53 166 41020 32927 42547222
Septic shock 139.44 15.53 287 40899 91385 42488764
Trichoglossia 138.00 15.53 38 41148 349 42579800
Antimicrobial susceptibility test resistant 123.46 15.53 35 41151 361 42579788
Multiple organ dysfunction syndrome 119.41 15.53 279 40907 96756 42483393
Eosinophilia 113.13 15.53 149 41037 32750 42547399
Myelosuppression 110.43 15.53 164 41022 40297 42539852
Ototoxicity 104.31 15.53 49 41137 2276 42577873
Pain 100.30 15.53 56 41130 244792 42335357
Fall 99.93 15.53 51 41135 234469 42345680
Toxic optic neuropathy 97.44 15.53 37 41149 1003 42579146
Rash maculo-papular 96.64 15.53 148 41038 37355 42542794
Drug ineffective 95.01 15.53 976 40210 629221 41950928
Visual acuity reduced 87.46 15.53 96 41090 17454 42562695
Drug ineffective for unapproved indication 86.58 15.53 158 41028 46005 42534144
Product dose omission issue 85.26 15.53 22 41164 154343 42425806
Bronchopulmonary aspergillosis 84.45 15.53 99 41087 19330 42560819
Respiratory failure 80.11 15.53 289 40897 127843 42452306
Candida infection 79.16 15.53 101 41085 21509 42558640
Treatment failure 79.10 15.53 182 41004 62442 42517707
Drug-induced liver injury 76.90 15.53 135 41051 38138 42542011
Alveolar lung disease 76.09 15.53 25 41161 437 42579712
Tooth discolouration 75.30 15.53 25 41161 452 42579697
Polyneuropathy 74.40 15.53 91 41095 18570 42561579
Intraocular pressure increased 71.15 15.53 55 41131 6378 42573771
Uveitis 68.95 15.53 63 41123 9195 42570954
Systemic candida 68.91 15.53 50 41136 5269 42574880
Product use in unapproved indication 64.78 15.53 350 40836 184106 42396043
Deafness neurosensory 64.59 15.53 42 41144 3704 42576445
Cardiac valve vegetation 64.56 15.53 23 41163 518 42579631
Hepatitis cholestatic 63.87 15.53 62 41124 9762 42570387
Antibiotic level above therapeutic 62.23 15.53 21 41165 400 42579749
Mitochondrial toxicity 62.18 15.53 36 41150 2579 42577570
Toxic epidermal necrolysis 61.21 15.53 100 41086 26650 42553499
Hypersensitivity vasculitis 59.96 15.53 38 41148 3206 42576943
Product use issue 58.41 15.53 185 41001 76566 42503583
Acute kidney injury 57.91 15.53 575 40611 366762 42213387
Back pain 57.16 15.53 33 41153 141743 42438406
Minimum inhibitory concentration 57.06 15.53 16 41170 158 42579991
Eosinophilic pneumonia 56.82 15.53 43 41143 4831 42575318
Dizziness 56.81 15.53 96 41090 249158 42330991
Arthralgia 56.68 15.53 69 41117 205169 42374980
Nasopharyngitis 54.70 15.53 8 41178 83988 42496161
Headache 53.80 15.53 93 41093 239276 42340873
Sideroblastic anaemia 53.05 15.53 18 41168 349 42579800
Cholestasis 52.35 15.53 105 41081 32774 42547375
Tongue discolouration 51.85 15.53 25 41161 1231 42578918
Eye pain 49.29 15.53 71 41115 16959 42563190
Pulmonary interstitial emphysema syndrome 49.06 15.53 19 41167 544 42579605
Deafness 49.04 15.53 62 41124 13078 42567071
Inappropriate schedule of product administration 48.64 15.53 16 41170 95886 42484263
Hypertransaminasaemia 48.63 15.53 52 41134 9175 42570974
Geotrichum infection 48.61 15.53 19 41167 558 42579591
Malignant neoplasm progression 48.50 15.53 22 41164 108378 42471771
Klebsiella infection 48.01 15.53 57 41129 11275 42568874
Cytopenia 47.82 15.53 71 41115 17426 42562723
Incorrect product administration duration 47.71 15.53 42 41144 5838 42574311
Hypolipidaemia 47.55 15.53 8 41178 0 42580149
Disseminated intravascular coagulation 46.64 15.53 85 41101 24709 42555440
Acute generalised exanthematous pustulosis 46.30 15.53 49 41137 8546 42571603
Constipation 45.38 15.53 54 41132 162237 42417912
Injection site pain 44.11 15.53 3 41183 57795 42522354
Completed suicide 44.06 15.53 19 41167 96446 42483703
Reticulocytopenia 43.26 15.53 13 41173 167 42579982
Myocardial infarction 43.09 15.53 34 41152 123975 42456174
Hepatic failure 42.97 15.53 106 41080 37994 42542155
Aspergillus infection 42.90 15.53 64 41122 15773 42564376
Vascular pseudoaneurysm thrombosis 42.70 15.53 11 41175 76 42580073
Renal impairment 41.96 15.53 214 40972 110014 42470135
Staphylococcal infection 41.68 15.53 104 41082 37539 42542610
Mycobacterium chelonae infection 41.36 15.53 21 41165 1157 42578992
Drug dispensed to wrong patient 39.97 15.53 16 41170 501 42579648
Anti factor V antibody 39.91 15.53 14 41172 301 42579848
Weight increased 39.58 15.53 28 41158 107955 42472194
Musculoskeletal stiffness 38.79 15.53 5 41181 57760 42522389
Dehydration 38.75 15.53 48 41138 141719 42438430
Intentional overdose 38.33 15.53 3 41183 51453 42528696
Somnolence 37.30 15.53 49 41137 141056 42439093
Pulmonary mucormycosis 37.19 15.53 21 41165 1434 42578715
Enterococcus test positive 36.91 15.53 22 41164 1663 42578486
Gastrointestinal disorder 36.90 15.53 114 41072 46539 42533610
Loss of personal independence in daily activities 36.84 15.53 3 41183 49813 42530336
Mixed liver injury 36.39 15.53 32 41154 4442 42575707
Haemodynamic instability 35.83 15.53 52 41134 12505 42567644
Psoriasis 35.74 15.53 3 41183 48601 42531548
Differentiation syndrome 35.42 15.53 22 41164 1791 42578358
Pain in extremity 35.20 15.53 57 41129 150547 42429602
Hypoacusis 35.03 15.53 64 41122 18638 42561511
Cough 34.92 15.53 75 41111 178028 42402121
Therapeutic response delayed 34.89 15.53 16 41170 703 42579446
Malaise 34.82 15.53 98 41088 212058 42368091
Memory impairment 34.57 15.53 4 41182 50218 42529931
Chest pain 34.34 15.53 51 41135 139479 42440670
Nocardiosis 34.20 15.53 33 41153 5157 42574992
Hyperbilirubinaemia 34.17 15.53 67 41119 20568 42559581
Gait disturbance 33.87 15.53 27 41159 97973 42482176
Mucormycosis 33.73 15.53 38 41148 7105 42573044
Aortoenteric fistula 33.67 15.53 10 41176 123 42580026
Joint swelling 33.36 15.53 12 41174 68010 42512139
CNS ventriculitis 33.35 15.53 13 41173 379 42579770
Cutaneous mucormycosis 33.34 15.53 15 41171 630 42579519
Dry skin 32.90 15.53 4 41182 48334 42531815
Dyspnoea 32.89 15.53 272 40914 442349 42137800
Leukopenia 32.66 15.53 151 41035 74595 42505554
Psoas abscess 32.39 15.53 16 41170 831 42579318
Insomnia 32.35 15.53 40 41146 118213 42461936
Sepsis 32.24 15.53 314 40872 199020 42381129
Stress 31.77 15.53 3 41183 44209 42535940
Cardiac disorder 31.07 15.53 5 41181 48927 42531222
Hallucination, visual 30.94 15.53 65 41121 20955 42559194
Muscle spasms 30.63 15.53 23 41163 86021 42494128
Immune reconstitution inflammatory syndrome 30.40 15.53 43 41143 10100 42570049
Myoclonus 30.21 15.53 57 41129 17008 42563141
Contusion 29.78 15.53 3 41183 41982 42538167
Respiratory gas exchange disorder 29.77 15.53 13 41173 508 42579641
Shock haemorrhagic 29.68 15.53 55 41131 16187 42563962
Foetal exposure during pregnancy 29.67 15.53 5 41181 47306 42532843
Nutritional condition abnormal 29.42 15.53 13 41173 523 42579626
Agranulocytosis 29.20 15.53 80 41106 30532 42549617
Tuberculosis 29.07 15.53 42 41144 10057 42570092
Hepatitis acute 28.32 15.53 39 41147 8936 42571213
Hyperleukocytosis 28.19 15.53 22 41164 2586 42577563
Wheezing 28.01 15.53 9 41177 54772 42525377
Hepatocellular injury 27.89 15.53 67 41119 23611 42556538
Wrong technique in product usage process 27.89 15.53 4 41182 42631 42537518
Tubulointerstitial nephritis 27.70 15.53 80 41106 31468 42548681
Cholangiolitis 26.88 15.53 6 41180 20 42580129
Syncope 26.79 15.53 34 41152 99372 42480777
Hepatic cytolysis 26.45 15.53 71 41115 26773 42553376
Haematotoxicity 26.39 15.53 42 41144 10943 42569206
Hospitalisation 26.29 15.53 20 41166 74310 42505839
Megacolon 26.28 15.53 20 41166 2265 42577884
Diffuse alveolar damage 26.16 15.53 21 41165 2571 42577578
Thrombosis 26.12 15.53 17 41169 68494 42511655
Acinetobacter infection 25.99 15.53 17 41169 1514 42578635
Brain abscess 25.92 15.53 26 41160 4258 42575891
Blood glucose increased 25.85 15.53 20 41166 73679 42506470
Optic nerve disorder 25.62 15.53 13 41173 715 42579434
Rheumatoid arthritis 25.51 15.53 5 41181 42435 42537714
Condition aggravated 25.46 15.53 373 40813 260381 42319768
Coronary artery disease 25.46 15.53 10 41176 53710 42526439
Aplasia pure red cell 25.46 15.53 33 41153 7133 42573016
Death 25.26 15.53 313 40873 470872 42109277
Asthenia 24.90 15.53 164 41022 280629 42299520
Botulism 24.84 15.53 9 41177 213 42579936
Transaminases increased 24.75 15.53 79 41107 32806 42547343
Cardiac failure congestive 24.43 15.53 28 41158 85574 42494575
Hypofibrinogenaemia 24.37 15.53 18 41168 1949 42578200
Depression 24.31 15.53 44 41142 111319 42468830
Pruritus 24.24 15.53 97 41089 188674 42391475
Clostridium test positive 23.83 15.53 28 41158 5477 42574672
Bronchitis 23.70 15.53 8 41178 47193 42532956
Nephropathy toxic 23.55 15.53 51 41135 16787 42563362
Herpes zoster meningoencephalitis 23.51 15.53 11 41175 506 42579643
Infusion related reaction 23.30 15.53 15 41171 60791 42519358
Pseudomonas infection 23.16 15.53 49 41137 15874 42564275
Feeling abnormal 23.15 15.53 20 41166 69766 42510383
Mycobacterial peritonitis 23.11 15.53 8 41178 165 42579984
Organ failure 23.01 15.53 19 41167 2421 42577728
Rectal perforation 22.83 15.53 11 41175 541 42579608
Acute myocardial infarction 22.77 15.53 14 41172 58151 42521998
Vascular purpura 22.68 15.53 18 41168 2168 42577981
Drug level decreased 22.41 15.53 37 41149 9940 42570209
Paradoxical drug reaction 22.02 15.53 25 41161 4713 42575436
Pulmonary resection 21.99 15.53 7 41179 110 42580039
Dysbiosis 21.67 15.53 12 41174 789 42579360
Axonal neuropathy 21.67 15.53 14 41172 1221 42578928
Drug level increased 21.62 15.53 65 41121 26135 42554014
Pneumonia 21.28 15.53 284 40902 421865 42158284
Shock 21.05 15.53 69 41117 29052 42551097
Hepatitis 20.92 15.53 66 41120 27234 42552915
Balance disorder 20.79 15.53 10 41176 47635 42532514
Staphylococcal bacteraemia 20.75 15.53 38 41148 11083 42569066
Oedema peripheral 20.75 15.53 65 41121 136011 42444138
Cerebrovascular accident 20.66 15.53 39 41147 97121 42483028
Renal failure 20.63 15.53 221 40965 143505 42436644
Cardiopulmonary failure 20.57 15.53 24 41162 4659 42575490
Pulmonary embolism 20.54 15.53 54 41132 119558 42460591
Asthma 20.50 15.53 18 41168 62296 42517853
Febrile neutropenia 20.47 15.53 101 41085 185602 42394547
Hyperhidrosis 20.44 15.53 35 41151 90477 42489672
Gastrooesophageal reflux disease 20.34 15.53 9 41177 45014 42535135
Peripheral swelling 20.30 15.53 35 41151 90235 42489914
Papilloma 20.25 15.53 9 41177 367 42579782
Metastases to muscle 20.21 15.53 8 41178 243 42579906
Wound drainage 20.15 15.53 11 41175 703 42579446
Myalgia 20.05 15.53 39 41147 96041 42484108
Musculoskeletal pain 19.88 15.53 4 41182 33336 42546813
Haemophagocytic lymphohistiocytosis 19.80 15.53 50 41136 18172 42561977
Urinary retention 19.77 15.53 8 41178 42206 42537943
Diarrhoea 19.76 15.53 320 40866 460529 42119620
Papillitis 19.76 15.53 6 41180 80 42580069
Nosocomial infection 19.75 15.53 14 41172 1422 42578727
Toxic skin eruption 19.68 15.53 42 41144 13688 42566461
Metastases to retroperitoneum 19.59 15.53 8 41178 264 42579885
Systemic mycosis 19.27 15.53 17 41169 2370 42577779
Toxic neuropathy 19.14 15.53 10 41176 585 42579564
Endocarditis bacterial 19.07 15.53 13 41173 1240 42578909
Atrial fibrillation 19.03 15.53 70 41116 139523 42440626
Pseudomembranous colitis 18.93 15.53 19 41167 3114 42577035
Nephrolithiasis 18.92 15.53 6 41180 36824 42543325
Bacteraemia 18.70 15.53 60 41126 24980 42555169
Unevaluable event 18.69 15.53 5 41181 34283 42545866
Drug clearance decreased 18.56 15.53 16 41170 2162 42577987
Therapeutic product effect incomplete 18.36 15.53 25 41161 70914 42509235
Splenic infection fungal 18.25 15.53 6 41180 105 42580044
Hepatic haemorrhage 18.09 15.53 10 41176 655 42579494
Embolic cerebral infarction 17.91 15.53 11 41175 878 42579271
Anxiety 17.82 15.53 57 41129 118503 42461646
Incorrect dose administered 17.79 15.53 15 41171 52959 42527190
Generalised oedema 17.64 15.53 43 41143 15293 42564856
Multiple-drug resistance 17.60 15.53 28 41158 7294 42572855
Splenic necrosis 17.55 15.53 6 41180 119 42580030
Blood culture negative 17.51 15.53 5 41181 53 42580096
Therapeutic product effect decreased 17.41 15.53 8 41178 39142 42541007
Intervertebral discitis 17.33 15.53 18 41168 3072 42577077
Fungal infection 17.30 15.53 50 41136 19672 42560477
Neck pain 17.09 15.53 4 41182 30010 42550139
Full blood count abnormal 16.97 15.53 4 41182 29872 42550277
Metastases to bone marrow 16.97 15.53 9 41177 543 42579606
Overdose 16.96 15.53 49 41137 105215 42474934
Normocytic anaemia 16.84 15.53 19 41167 3558 42576591
Blood pressure increased 16.75 15.53 47 41139 101881 42478268
Influenza like illness 16.69 15.53 5 41181 31835 42548314
Endocarditis 16.68 15.53 29 41157 8123 42572026
Fluid retention 16.51 15.53 5 41181 31614 42548535
Peripheral sensory neuropathy 16.42 15.53 30 41156 8732 42571417
Blood cholesterol increased 16.39 15.53 3 41183 26738 42553411
Sinusitis 16.37 15.53 13 41173 47279 42532870
Adrenergic syndrome 16.29 15.53 6 41180 149 42580000
Brief psychotic disorder with marked stressors 16.19 15.53 7 41179 267 42579882
Mobility decreased 16.04 15.53 7 41179 35299 42544850
Prothrombin time prolonged 15.98 15.53 31 41155 9438 42570711
False negative investigation result 15.95 15.53 7 41179 277 42579872
Purpura non-thrombocytopenic 15.93 15.53 5 41181 75 42580074
Wound dehiscence 15.91 15.53 19 41167 3781 42576368
Dyspnoea exertional 15.88 15.53 15 41171 50133 42530016
Myasthenia gravis crisis 15.86 15.53 10 41176 836 42579313
Chorioretinitis 15.84 15.53 9 41177 622 42579527
Red blood cell vacuolisation 15.75 15.53 3 41183 3 42580146
Pancreatitis 15.74 15.53 83 41103 43185 42536964
Suicidal ideation 15.74 15.53 14 41172 48147 42532002

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Thrombocytopenia 2227.19 15.13 1798 67508 347087 110172906
Lactic acidosis 1430.75 15.13 827 68479 91984 110428009
Serotonin syndrome 1217.12 15.13 638 68668 58515 110461478
Anaemia 923.53 15.13 1402 67904 545684 109974309
Drug resistance 783.06 15.13 470 68836 55904 110464089
Pancytopenia 736.69 15.13 776 68530 208837 110311156
Electrocardiogram QT prolonged 686.30 15.13 559 68747 108401 110411592
Neuropathy peripheral 619.57 15.13 658 68648 178619 110341374
Platelet count decreased 546.76 15.13 697 68609 229746 110290247
Off label use 533.60 15.13 2095 67211 1498090 109021903
Drug interaction 529.42 15.13 1044 68262 499139 110020854
Optic neuropathy 524.09 15.13 170 69136 4488 110515505
Pathogen resistance 509.68 15.13 240 69066 17432 110502561
Drug reaction with eosinophilia and systemic symptoms 438.10 15.13 383 68923 81712 110438281
Multiple organ dysfunction syndrome 411.32 15.13 491 68815 151219 110368774
Septic shock 377.30 15.13 479 68827 157049 110362944
Fatigue 351.82 15.13 162 69144 1215796 109304197
Pain 312.49 15.13 105 69201 954850 109565143
Myelosuppression 283.39 15.13 322 68984 94018 110425975
Hyperlactacidaemia 281.11 15.13 126 69180 8160 110511833
Bicytopenia 269.56 15.13 115 69191 6609 110513384
Optic neuritis 263.04 15.13 132 69174 11015 110508978
Eosinophilia 247.98 15.13 239 69067 57697 110462296
Acute kidney injury 242.18 15.13 910 68396 634520 109885473
Hepatotoxicity 229.86 15.13 239 69067 63161 110456832
Bone marrow failure 229.61 15.13 229 69077 57619 110462374
Respiratory failure 221.61 15.13 445 68861 214887 110305106
Enterococcal infection 217.83 15.13 144 69162 20222 110499771
Mitochondrial toxicity 215.85 15.13 80 69226 3165 110516828
Choroiditis 214.95 15.13 67 69239 1548 110518445
Trichoglossia 207.95 15.13 57 69249 823 110519170
Nasopharyngitis 205.48 15.13 10 69296 394351 110125642
Toxic optic neuropathy 197.54 15.13 60 69246 1268 110518725
Joint swelling 181.23 15.13 30 69276 442815 110077178
Polyneuropathy 180.06 15.13 154 69152 31858 110488135
Arthralgia 179.57 15.13 136 69170 779496 109740497
Ototoxicity 170.06 15.13 72 69234 4059 110515934
Hypertransaminasaemia 164.30 15.13 130 69176 24125 110495868
Drug ineffective 161.57 15.13 1554 67752 1518986 109001007
Rash maculo-papular 159.33 15.13 214 69092 74008 110445985
Infusion related reaction 157.78 15.13 25 69281 381137 110138856
Arthropathy 157.49 15.13 5 69301 287517 110232476
Drug ineffective for unapproved indication 154.96 15.13 251 69055 102587 110417406
Antimicrobial susceptibility test resistant 149.99 15.13 38 69268 396 110519597
Synovitis 149.29 15.13 5 69301 274087 110245906
Headache 148.45 15.13 202 69104 882175 109637818
Fall 139.19 15.13 105 69201 603377 109916616
Rheumatoid arthritis 132.58 15.13 16 69290 299597 110220396
Acute generalised exanthematous pustulosis 131.69 15.13 109 69197 21555 110498438
Aspergillus infection 131.52 15.13 117 69189 25499 110494494
Bronchopulmonary aspergillosis 129.27 15.13 124 69182 29739 110490254
Candida infection 127.66 15.13 154 69152 47855 110472138
Weight increased 127.03 15.13 52 69254 419592 110100401
Swelling 126.56 15.13 32 69274 351009 110168984
Sepsis 122.80 15.13 467 68839 326879 110193114
Alopecia 122.67 15.13 38 69268 364715 110155278
Staphylococcal infection 122.50 15.13 183 69123 69761 110450232
Tooth discolouration 122.47 15.13 42 69264 1321 110518672
Hepatic cytolysis 120.08 15.13 160 69146 54893 110465100
Cholestasis 119.04 15.13 173 69133 64345 110455648
Therapeutic product effect decreased 118.76 15.13 9 69297 244307 110275686
Product dose omission issue 118.60 15.13 28 69278 321754 110198239
Sinusitis 117.17 15.13 22 69284 296666 110223327
Pemphigus 113.13 15.13 5 69301 214565 110305428
Systemic lupus erythematosus 111.49 15.13 14 69292 254324 110265669
Pain in extremity 109.41 15.13 87 69219 487031 110032962
Peripheral swelling 108.54 15.13 59 69247 403975 110116018
Musculoskeletal stiffness 107.87 15.13 22 69284 279800 110240193
Visual acuity reduced 107.20 15.13 116 69190 32057 110487936
Contusion 106.92 15.13 11 69295 233350 110286643
Leukopenia 106.30 15.13 266 69040 148525 110371468
Renal failure 106.26 15.13 348 68958 226226 110293767
Renal impairment 105.60 15.13 308 68998 188137 110331856
Systemic candida 105.39 15.13 70 69236 9904 110510089
Malaise 104.79 15.13 162 69144 671657 109848336
Geotrichum infection 103.68 15.13 36 69270 1176 110518817
Glossodynia 102.92 15.13 10 69296 221994 110297999
Mobility decreased 101.83 15.13 14 69292 237408 110282585
Pericarditis 101.24 15.13 10 69296 219104 110300889
Completed suicide 100.02 15.13 16 69290 242365 110277628
Product use in unapproved indication 99.47 15.13 547 68759 446830 110073163
Impaired healing 99.25 15.13 6 69300 196711 110323282
Hepatitis cholestatic 97.75 15.13 84 69222 17482 110502511
Type 2 diabetes mellitus 97.32 15.13 3 69303 177229 110342764
Wound 95.57 15.13 16 69290 234421 110285572
Clostridium difficile colitis 95.12 15.13 127 69179 43651 110476342
Injection site pain 94.28 15.13 4 69302 177918 110342075
Klebsiella infection 94.10 15.13 87 69219 19922 110500071
Antibiotic level above therapeutic 93.47 15.13 32 69274 1001 110518992
Disseminated intravascular coagulation 93.14 15.13 122 69184 41164 110478829
Memory impairment 90.95 15.13 9 69297 196935 110323058
Wheezing 90.56 15.13 24 69282 255206 110264787
Toxic epidermal necrolysis 90.28 15.13 142 69164 56585 110463408
Hepatic failure 89.21 15.13 157 69149 68582 110451411
Migraine 87.31 15.13 5 69301 171647 110348346
Metabolic acidosis 87.22 15.13 193 69113 99551 110420442
Tongue discolouration 86.61 15.13 45 69261 4036 110515957
Discomfort 84.59 15.13 16 69290 214691 110305302
Hyperbilirubinaemia 84.18 15.13 100 69206 30571 110489422
Folliculitis 81.96 15.13 6 69300 167647 110352346
Hepatocellular injury 80.91 15.13 127 69179 50515 110469478
Muscle spasms 80.11 15.13 37 69269 278120 110241873
Injury 79.55 15.13 9 69297 177256 110342737
Musculoskeletal pain 77.99 15.13 11 69295 183012 110336981
Aplasia pure red cell 77.32 15.13 57 69249 9521 110510472
Back pain 76.29 15.13 72 69234 370924 110149069
Dizziness 76.01 15.13 207 69099 697986 109822007
Alveolar lung disease 75.86 15.13 25 69281 694 110519299
Ill-defined disorder 75.58 15.13 6 69300 156847 110363146
Sideroblastic anaemia 74.18 15.13 22 69284 427 110519566
Abdominal discomfort 72.48 15.13 84 69222 393774 110126219
Pseudomonas infection 71.85 15.13 88 69218 27765 110492228
Stomatitis 71.76 15.13 40 69266 270202 110249791
Paradoxical drug reaction 71.65 15.13 55 69251 9762 110510231
Eosinophilic pneumonia 69.86 15.13 48 69258 7179 110512814
Cytopenia 69.49 15.13 90 69216 30026 110489967
Haematotoxicity 68.47 15.13 75 69231 21007 110498986
C-reactive protein abnormal 68.43 15.13 3 69303 129692 110390301
Nocardiosis 68.33 15.13 48 69258 7438 110512555
Asthma 67.98 15.13 36 69270 250255 110269738
Psoriasis 65.69 15.13 6 69300 139987 110380006
Skin candida 65.21 15.13 31 69275 2297 110517696
Papillitis 65.06 15.13 16 69290 146 110519847
Deafness neurosensory 63.95 15.13 51 69255 9568 110510425
Gastrooesophageal reflux disease 63.69 15.13 17 69289 179959 110340034
Hypoglycaemia 63.32 15.13 188 69118 115916 110404077
Cardiac valve vegetation 63.20 15.13 24 69282 1016 110518977
Drug-induced liver injury 63.20 15.13 192 69114 119875 110400118
Haemophagocytic lymphohistiocytosis 63.18 15.13 88 69218 31471 110488522
Maternal exposure during pregnancy 63.08 15.13 41 69265 254842 110265151
Intraocular pressure increased 62.54 15.13 53 69253 10823 110509170
Insomnia 62.03 15.13 81 69225 360509 110159484
Mixed liver injury 61.66 15.13 55 69251 12024 110507969
Osteoarthritis 61.40 15.13 19 69287 182604 110337389
Multiple-drug resistance 61.18 15.13 57 69249 13178 110506815
Tuberculosis 60.82 15.13 65 69241 17709 110502284
Transaminases increased 60.38 15.13 127 69179 63263 110456730
Drug level decreased 60.26 15.13 66 69240 18482 110501511
Contraindicated product administered 60.00 15.13 41 69265 248226 110271767
Minimum inhibitory concentration 59.06 15.13 15 69291 158 110519835
Encephalopathy 59.01 15.13 146 69160 80909 110439084
Deafness 58.81 15.13 78 69228 26631 110493362
Obesity 58.58 15.13 3 69303 113348 110406645
Uveitis 58.29 15.13 70 69236 21640 110498353
Agranulocytosis 57.97 15.13 123 69183 61637 110458356
Differentiation syndrome 57.35 15.13 31 69275 3013 110516980
Toxic skin eruption 56.99 15.13 78 69228 27437 110492556
Drug level increased 56.82 15.13 105 69201 47614 110472379
Pulmonary interstitial emphysema syndrome 56.70 15.13 19 69287 556 110519437
Pancreatitis acute 56.53 15.13 120 69186 60154 110459839
Sleep disorder 56.29 15.13 27 69279 198617 110321376
Hallucination, visual 56.03 15.13 94 69212 39511 110480482
Myoclonus 55.86 15.13 85 69221 32913 110487080
Dysbiosis 55.51 15.13 27 69279 2105 110517888
Night sweats 54.91 15.13 9 69297 133974 110386019
Cough 54.70 15.13 131 69175 461510 110058483
Intentional overdose 54.08 15.13 9 69297 132492 110387501
Brain abscess 53.98 15.13 40 69266 6734 110513259
Bronchitis 53.40 15.13 16 69290 157016 110362977
Hypersensitivity vasculitis 53.13 15.13 40 69266 6897 110513096
Shock 52.95 15.13 109 69197 53479 110466514
Inappropriate schedule of product administration 52.82 15.13 31 69275 203606 110316387
Blood lactic acid increased 52.62 15.13 57 69249 15764 110504229
Anxiety 52.01 15.13 85 69221 344993 110175000
Incorrect product administration duration 51.64 15.13 64 69242 20434 110499559
Lower respiratory tract infection 51.35 15.13 46 69260 243060 110276933
Therapeutic product effect incomplete 50.15 15.13 40 69266 223765 110296228
Gait inability 49.95 15.13 12 69294 136364 110383629
Chest pain 49.34 15.13 101 69205 376274 110143719
Pruritus 48.98 15.13 193 69113 581367 109938626
Bacteraemia 48.88 15.13 92 69214 42298 110477695
Neck pain 48.86 15.13 9 69297 123121 110396872
Hypersensitivity 48.36 15.13 114 69192 403884 110116109
Hypertension 47.74 15.13 162 69144 509922 110010071
Acute respiratory distress syndrome 47.69 15.13 104 69202 53094 110466899
Mucormycosis 47.64 15.13 45 69261 10583 110509410
Malignant neoplasm progression 47.55 15.13 25 69281 174542 110345451
Vascular pseudoaneurysm thrombosis 46.94 15.13 11 69295 80 110519913
Blister 46.86 15.13 44 69262 227332 110292661
Hallucination 46.78 15.13 155 69151 101277 110418716
Joint range of motion decreased 46.06 15.13 10 69296 121822 110398171
Muscular weakness 45.67 15.13 53 69253 248415 110271578
Arthritis 45.65 15.13 24 69282 167562 110352431
Anti factor V antibody 45.56 15.13 14 69292 308 110519685
Abdominal pain upper 45.49 15.13 94 69212 349017 110170976
Meningitis tuberculous 45.16 15.13 20 69286 1258 110518735
Acinetobacter infection 44.98 15.13 28 69278 3545 110516448
Blood disorder 44.86 15.13 42 69264 9768 110510225
Hepatitis acute 44.74 15.13 57 69249 18709 110501284
Hypolipidaemia 44.63 15.13 7 69299 0 110519993
Haemodynamic instability 44.59 15.13 63 69243 22825 110497168
Injection site reaction 44.07 15.13 3 69303 89067 110430926
Nephropathy toxic 44.01 15.13 69 69237 27409 110492584
Pneumothorax 43.73 15.13 79 69227 35206 110484787
Feeling abnormal 43.45 15.13 30 69276 180681 110339312
Depression 43.44 15.13 83 69223 317252 110202741
Stress 43.34 15.13 7 69299 105341 110414652
Wrong technique in product usage process 43.05 15.13 3 69303 87345 110432648
Hypokalaemia 42.42 15.13 226 69080 182222 110337771
Pancreatitis 42.31 15.13 142 69164 93391 110426602
Rash morbilliform 42.17 15.13 37 69269 7914 110512079
Neutropenia 41.87 15.13 388 68918 374232 110145761
Nervous system disorder 41.86 15.13 73 69233 31648 110488345
Fluid retention 41.77 15.13 5 69301 94302 110425691
Hyponatraemia 41.68 15.13 256 69050 217397 110302596
Nasal congestion 41.64 15.13 6 69300 98276 110421717
Haemoglobin decreased 41.17 15.13 282 69024 248445 110271548
Mycobacterium chelonae infection 41.12 15.13 25 69281 3035 110516958
Drug dispensed to wrong patient 40.93 15.13 16 69290 733 110519260
Reticulocytopenia 40.92 15.13 13 69293 320 110519673
Pulmonary mucormycosis 40.86 15.13 22 69284 2121 110517872
Road traffic accident 40.22 15.13 9 69297 107389 110412604
Coagulopathy 40.17 15.13 83 69223 40828 110479165
Hypomagnesaemia 39.03 15.13 104 69202 60266 110459727
Drug level below therapeutic 38.73 15.13 42 69264 11631 110508362
Immune reconstitution inflammatory syndrome 38.23 15.13 49 69257 16177 110503816
Prescribed overdose 37.93 15.13 5 69301 87576 110432417
Hypoacusis 37.66 15.13 74 69232 35117 110484876
Enterococcus test positive 37.17 15.13 23 69283 2881 110517112
Colitis ulcerative 37.15 15.13 3 69303 77360 110442633
Mycobacterium abscessus infection 36.75 15.13 19 69287 1687 110518306
Aortoenteric fistula 36.19 15.13 10 69296 149 110519844
Endocarditis 35.71 15.13 43 69263 13328 110506665
Dyspnoea 35.43 15.13 485 68821 1106387 109413606
Infective pulmonary exacerbation of cystic fibrosis 35.42 15.13 45 69261 14726 110505267
Drug eruption 35.26 15.13 93 69213 53566 110466427
Urinary tract infection 35.23 15.13 97 69209 326185 110193808
Neurotoxicity 35.01 15.13 80 69226 42127 110477866
Hepatic enzyme increased 34.94 15.13 95 69211 320797 110199196
Blood creatine phosphokinase increased 34.89 15.13 113 69193 72964 110447029
Toxic leukoencephalopathy 34.80 15.13 18 69288 1599 110518394
Dry skin 34.77 15.13 12 69294 107641 110412352
Somnolence 34.73 15.13 85 69221 297364 110222629
Inflammation 34.67 15.13 42 69264 193196 110326797
Product quality issue 34.48 15.13 4 69302 77295 110442698
Therapeutic response delayed 34.38 15.13 17 69289 1373 110518620
Cutaneous mucormycosis 34.35 15.13 14 69292 716 110519277
Hepatitis toxic 34.34 15.13 29 69277 5892 110514101
Blood pressure increased 34.13 15.13 69 69237 258304 110261689
Peripheral sensory neuropathy 34.12 15.13 47 69259 16633 110503360
Shock haemorrhagic 33.76 15.13 61 69245 27186 110492807
Hyperleukocytosis 33.61 15.13 23 69283 3416 110516577
Pulmonary fibrosis 33.61 15.13 11 69295 102031 110417962
Lung disorder 33.52 15.13 38 69268 180009 110339984
Cystic fibrosis 33.42 15.13 26 69280 4705 110515288
Pneumonia necrotising 33.22 15.13 18 69288 1757 110518236
Pancreatitis haemorrhagic 33.03 15.13 15 69291 1001 110518992
Organ failure 33.01 15.13 26 69280 4791 110515202
Cardiopulmonary failure 32.66 15.13 32 69274 7871 110512122
Live birth 32.53 15.13 3 69303 69481 110450512
Diffuse alveolar damage 32.48 15.13 24 69282 4023 110515970
Mediastinal effusion 32.43 15.13 8 69298 74 110519919
Pseudomembranous colitis 32.42 15.13 29 69277 6362 110513631
Hepatitis fulminant 32.32 15.13 33 69273 8527 110511466
Syncope 32.30 15.13 48 69258 202488 110317505
Rhinorrhoea 32.21 15.13 12 69294 102654 110417339
Diabetic macroangiopathy 32.03 15.13 9 69297 143 110519850
Purpura 32.02 15.13 56 69250 24332 110495661
International normalised ratio increased 31.81 15.13 123 69183 86649 110433344
Fungal infection 31.31 15.13 86 69220 50720 110469273
Cough decreased 30.75 15.13 6 69300 15 110519978
Blood pressure fluctuation 30.71 15.13 5 69301 74819 110445174
Illness 30.54 15.13 7 69299 82164 110437829
Psoas abscess 30.27 15.13 16 69290 1486 110518507
Knee arthroplasty 29.89 15.13 3 69303 64945 110455048
Gait disturbance 29.81 15.13 83 69223 278125 110241868
Loss of personal independence in daily activities 29.78 15.13 30 69276 149990 110370003
Respiratory distress 29.77 15.13 103 69203 68771 110451222
Staphylococcal bacteraemia 29.69 15.13 44 69262 16644 110503349
Oedema peripheral 29.63 15.13 106 69200 328554 110191439
Generalised tonic-clonic seizure 29.28 15.13 88 69218 54592 110465401
Myocardial infarction 29.21 15.13 47 69259 192036 110327957
Herpes zoster meningoencephalitis 29.11 15.13 14 69292 1064 110518929
Posterior reversible encephalopathy syndrome 29.00 15.13 65 69241 33796 110486197
CNS ventriculitis 28.92 15.13 12 69294 643 110519350
Blood fibrinogen decreased 28.81 15.13 19 69287 2656 110517337
Haemoperitoneum 28.43 15.13 25 69281 5363 110514630
Cholangiolitis 28.42 15.13 6 69300 25 110519968
Influenza like illness 28.30 15.13 10 69296 88402 110431591
Enterococcal bacteraemia 28.27 15.13 23 69283 4438 110515555
Injection site swelling 28.06 15.13 3 69303 61787 110458206
Aspartate aminotransferase increased 28.05 15.13 184 69122 159752 110360241
Inappropriate antidiuretic hormone secretion 27.90 15.13 64 69242 33787 110486206
Rhabdomyolysis 27.88 15.13 149 69157 120252 110399741
Prescribed underdose 27.56 15.13 4 69302 65170 110454823
Wound infection 27.49 15.13 13 69293 96452 110423541
Hypofibrinogenaemia 27.47 15.13 18 69288 2489 110517504
Constipation 27.44 15.13 123 69183 357663 110162330
Clostridium test positive 27.42 15.13 34 69272 10859 110509134
Disseminated tuberculosis 27.40 15.13 24 69282 5122 110514871
Pulmonary tuberculosis 27.08 15.13 31 69275 9108 110510885
Flushing 27.07 15.13 16 69290 104720 110415273
Oedematous kidney 26.93 15.13 9 69297 261 110519732
Oropharyngeal pain 26.91 15.13 27 69279 135249 110384744
Megacolon 26.87 15.13 22 69284 4283 110515710
Serratia infection 26.67 15.13 17 69289 2242 110517751
Feeling hot 26.39 15.13 12 69294 91094 110428899
Atypical mycobacterial infection 26.15 15.13 18 69288 2700 110517293
Product prescribing issue 26.14 15.13 36 69270 12736 110507257
Eosinophilic pneumonia acute 26.03 15.13 15 69291 1650 110518343
Optic nerve disorder 25.71 15.13 15 69291 1688 110518305
Blood bilirubin increased 25.68 15.13 105 69201 75867 110444126
Red blood cell vacuolisation 25.48 15.13 5 69301 13 110519980
Cataract 25.43 15.13 9 69297 79476 110440517
Pulmonary resection 25.38 15.13 8 69298 192 110519801
Acid base balance abnormal 25.32 15.13 10 69296 471 110519522
Respiratory gas exchange disorder 25.28 15.13 12 69294 886 110519107
Cerebrovascular accident 25.16 15.13 47 69259 181237 110338756
Toxicity to various agents 25.14 15.13 432 68874 480123 110039870
Condition aggravated 25.07 15.13 620 68686 734216 109785777
Drug hypersensitivity 25.07 15.13 174 69132 453916 110066077
Hypocapnia 24.98 15.13 12 69294 910 110519083
Pneumonia fungal 24.96 15.13 38 69268 14716 110505277
Blood creatinine increased 24.91 15.13 198 69108 182691 110337302
Systemic mycosis 24.81 15.13 20 69286 3809 110516184
Intentional product misuse 24.79 15.13 28 69278 132876 110387117
Hepatitis 24.76 15.13 117 69189 89937 110430056
Incorrect route of product administration 24.74 15.13 5 69301 64056 110455937
Acute respiratory failure 24.64 15.13 103 69203 75157 110444836
Disseminated mycobacterium avium complex infection 24.60 15.13 10 69296 508 110519485
Tachypnoea 24.59 15.13 67 69239 39328 110480665
Reticulocyte count decreased 24.45 15.13 12 69294 954 110519039
Band neutrophil count decreased 24.36 15.13 7 69299 121 110519872
Pulmonary nocardiosis 24.33 15.13 17 69289 2612 110517381
Vestibular disorder 24.31 15.13 17 69289 2615 110517378
Hepatic infarction 24.27 15.13 12 69294 969 110519024
Glossitis 23.98 15.13 21 69285 4480 110515513
Mycobacterial peritonitis 23.84 15.13 8 69298 235 110519758
Exfoliative rash 23.69 15.13 21 69285 4553 110515440
Peripheral motor neuropathy 23.67 15.13 20 69286 4066 110515927
Otitis media fungal 23.65 15.13 5 69301 21 110519972
Rectal perforation 23.64 15.13 12 69294 1025 110518968
Mitochondrial cytopathy 23.59 15.13 9 69297 386 110519607
Nutritional condition abnormal 23.57 15.13 13 69293 1314 110518679
Immune reconstitution inflammatory syndrome associated tuberculosis 23.46 15.13 12 69294 1042 110518951
Respiratory alkalosis 23.34 15.13 23 69283 5698 110514295
Bone pain 23.32 15.13 6 69300 65127 110454866
Therapeutic response decreased 23.22 15.13 16 69290 96483 110423510
Red blood cell sedimentation rate increased 23.18 15.13 10 69296 78292 110441701
Cholecystitis acute 23.05 15.13 38 69268 15744 110504249
Vascular purpura 22.97 15.13 19 69287 3752 110516241
Acute hepatic failure 22.74 15.13 62 69244 36406 110483587
Toxic neuropathy 22.74 15.13 12 69294 1111 110518882
Erythropoiesis abnormal 22.49 15.13 10 69296 635 110519358
Tubulointerstitial nephritis 22.44 15.13 80 69226 54204 110465789
Thrombosis 22.41 15.13 21 69285 108641 110411352
Acute febrile neutrophilic dermatosis 22.32 15.13 21 69285 4915 110515078
Weight decreased 22.23 15.13 187 69119 467870 110052123
Aplasia 22.15 15.13 26 69280 7847 110512146
Stevens-Johnson syndrome 21.91 15.13 72 69234 46829 110473164
Wound dehiscence 21.91 15.13 26 69280 7936 110512057
Pregnancy 21.91 15.13 3 69303 51064 110468929
Encephalitis 21.86 15.13 41 69265 18798 110501195
Escherichia infection 21.85 15.13 47 69259 23769 110496224
Raoultella ornithinolytica infection 21.82 15.13 7 69299 178 110519815
Axonal neuropathy 21.47 15.13 15 69291 2303 110517690
Hepatosplenomegaly 21.41 15.13 24 69282 6895 110513098
Adrenal cortex necrosis 21.38 15.13 5 69301 36 110519957
Frequent bowel movements 21.32 15.13 9 69297 71381 110448612
Wound drainage 21.06 15.13 12 69294 1292 110518701
Intracranial infection 21.04 15.13 8 69298 340 110519653
Normocytic anaemia 20.99 15.13 23 69283 6444 110513549
Botulism 20.91 15.13 9 69297 528 110519465
Papilloma 20.85 15.13 9 69297 532 110519461
Influenza 20.79 15.13 47 69259 169054 110350939
Full blood count abnormal 20.39 15.13 5 69301 56047 110463946
Orthostatic hypotension 20.35 15.13 8 69298 66241 110453752
Blood albumin decreased 20.32 15.13 50 69256 27602 110492391
Metastases to muscle 20.25 15.13 8 69298 377 110519616
Ear infection 20.24 15.13 7 69299 62725 110457268
Pericarditis tuberculous 20.21 15.13 6 69300 117 110519876
Leuconostoc infection 20.20 15.13 5 69301 47 110519946
Staphylococcus test positive 20.17 15.13 24 69282 7346 110512647
Clostridium difficile infection 20.01 15.13 75 69231 52054 110467939
Lymphopenia 19.98 15.13 63 69243 40107 110479886
Pulmonary function test 19.97 15.13 4 69302 12 110519981
Myalgia 19.85 15.13 72 69234 222309 110297684
Alanine aminotransferase increased 19.83 15.13 189 69117 183584 110336409
Cytomegalovirus infection 19.81 15.13 77 69229 54367 110465626
Procalcitonin increased 19.78 15.13 18 69288 4038 110515955
Muscle abscess 19.73 15.13 12 69294 1457 110518536
Dry mouth 19.71 15.13 62 69244 199886 110320107
Portal vein cavernous transformation 19.52 15.13 6 69300 132 110519861
Enterobacter infection 19.44 15.13 21 69285 5790 110514203
Metastases to retroperitoneum 19.43 15.13 8 69298 420 110519573
Long QT syndrome 19.19 15.13 23 69283 7095 110512898
Eye pain 19.17 15.13 72 69234 50027 110469966
Torticollis 19.14 15.13 16 69290 3205 110516788
Septal panniculitis 19.07 15.13 6 69300 143 110519850
Generalised oedema 18.95 15.13 52 69254 30652 110489341
Anuria 18.94 15.13 45 69261 24296 110495697
Glomerular filtration rate abnormal 18.83 15.13 14 69292 2369 110517624
Pneumonia klebsiella 18.82 15.13 22 69284 6610 110513383
Device related infection 18.76 15.13 61 69245 39458 110480535
Relapsing fever 18.74 15.13 8 69298 460 110519533
Pyelonephritis chronic 18.58 15.13 7 69299 290 110519703
Clonus 18.49 15.13 25 69281 8691 110511302
Transaminases abnormal 18.44 15.13 10 69296 978 110519015
Hydrothorax 18.40 15.13 12 69294 1646 110518347
Taste disorder 18.34 15.13 9 69297 65378 110454615
Splenic infection fungal 18.33 15.13 6 69300 163 110519830
Mycobacterium fortuitum infection 18.23 15.13 8 69298 492 110519501
Alternaria infection 18.21 15.13 10 69296 1002 110518991
Hepatic haemorrhage 18.18 15.13 11 69295 1323 110518670
Urticaria 18.17 15.13 121 69185 318736 110201257
Optic atrophy 18.13 15.13 14 69292 2507 110517486
Pulmonary haemorrhage 18.09 15.13 35 69271 16421 110503572
Enterocolitis 18.08 15.13 38 69268 18911 110501082
Clostridial infection 18.04 15.13 21 69285 6281 110513712
Agitation 17.99 15.13 127 69179 112924 110407069
Ecthyma 17.97 15.13 10 69296 1029 110518964
Neoplasm progression 17.96 15.13 9 69297 64586 110455407
Cognitive disorder 17.94 15.13 17 69289 87494 110432499
Drug effective for unapproved indication 17.91 15.13 32 69274 14135 110505858
Transient ischaemic attack 17.66 15.13 9 69297 63973 110456020
Mediastinitis 17.64 15.13 11 69295 1397 110518596
Depressed mood 17.63 15.13 8 69298 60801 110459192
Dehydration 17.51 15.13 103 69203 279408 110240585
Splenic necrosis 17.49 15.13 6 69300 189 110519804
Electrolyte imbalance 17.44 15.13 57 69249 36971 110483022
Ulcer 17.43 15.13 3 69303 43113 110476880
Head injury 17.38 15.13 3 69303 43014 110476979
Brief psychotic disorder with marked stressors 17.27 15.13 7 69299 353 110519640
Nosocomial infection 17.19 15.13 15 69291 3184 110516809
Coronary artery disease 17.09 15.13 12 69294 71678 110448315
Herbal toxicity 17.08 15.13 4 69302 29 110519964
Therapy interrupted 17.07 15.13 5 69301 49817 110470176
SJS-TEN overlap 17.07 15.13 12 69294 1862 110518131
Embolic cerebral infarction 16.96 15.13 11 69295 1495 110518498
Angular cheilitis 16.93 15.13 10 69296 1151 110518842
Infectious pleural effusion 16.93 15.13 18 69288 4873 110515120
Prothrombin time prolonged 16.92 15.13 35 69271 17226 110502767
Skin maceration 16.80 15.13 6 69300 213 110519780
Amnesia 16.78 15.13 25 69281 105383 110414610
Pseudomonas test positive 16.77 15.13 13 69293 2341 110517652
Pyrexia 16.73 15.13 705 68601 897560 109622433
Disturbance in attention 16.70 15.13 9 69297 61986 110458007
Acid fast bacilli infection 16.67 15.13 6 69300 218 110519775
Tuberculoma of central nervous system 16.62 15.13 8 69298 609 110519384
Bilirubin conjugated increased 16.60 15.13 20 69286 6204 110513789
Upper respiratory tract infection 16.55 15.13 36 69270 131292 110388701
Dysphonia 16.46 15.13 14 69292 75915 110444078
Surgery 16.41 15.13 3 69303 41280 110478713
Cutaneous vasculitis 16.41 15.13 29 69277 12700 110507293
Hospitalisation 16.40 15.13 41 69265 142452 110377541
Respiratory arrest 16.39 15.13 8 69298 58291 110461702
Vomiting 16.35 15.13 712 68594 909963 109610030
Leukocytosis 16.33 15.13 72 69234 53756 110466237
Suicidal ideation 16.23 15.13 21 69285 93916 110426077
Procalcitonin decreased 16.14 15.13 5 69301 113 110519880
Hyperammonaemia 16.07 15.13 30 69276 13702 110506291
Osteomyelitis 16.05 15.13 55 69251 36545 110483448
Pain in jaw 16.02 15.13 6 69300 51171 110468822
Suicide attempt 16.00 15.13 25 69281 103369 110416624
Hypoalbuminaemia 15.86 15.13 47 69259 28927 110491066
Aplastic anaemia 15.83 15.13 42 69264 24266 110495727
Hepatic function abnormal 15.82 15.13 103 69203 89192 110430801
Drug clearance decreased 15.76 15.13 16 69290 4106 110515887
Arthritis bacterial 15.73 15.13 26 69280 10794 110509199
Drug level fluctuating 15.72 15.13 9 69297 978 110519015
Immune effector cell-associated neurotoxicity syndrome 15.71 15.13 31 69275 14751 110505242
Swelling face 15.59 15.13 21 69285 92300 110427693
Diverticulitis 15.58 15.13 7 69299 53515 110466478
Haemolytic anaemia 15.55 15.13 38 69268 20882 110499111
Candida test positive 15.51 15.13 10 69296 1345 110518648
Staphylococcal sepsis 15.50 15.13 34 69272 17420 110502573
Metastases to bone marrow 15.49 15.13 9 69297 1005 110518988
Seizure 15.47 15.13 209 69097 220976 110299017
Dermatitis exfoliative generalised 15.46 15.13 26 69280 10946 110509047
Adrenergic syndrome 15.43 15.13 6 69300 271 110519722
Benign soft tissue neoplasm 15.41 15.13 5 69301 132 110519861
Unevaluable event 15.37 15.13 9 69297 59218 110460775
Delayed graft function 15.33 15.13 16 69290 4241 110515752
Bone tuberculosis 15.27 15.13 8 69298 730 110519263
Acute myocardial infarction 15.24 15.13 18 69288 83759 110436234
Rash 15.20 15.13 395 68911 820569 109699424
Deafness bilateral 15.18 15.13 13 69293 2691 110517302
Hip arthroplasty 15.18 15.13 8 69298 55805 110464188
Endocarditis bacterial 15.15 15.13 11 69295 1794 110518199

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01XX08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER ANTIBACTERIALS
Other antibacterials
FDA CS M0361132 Oxazolidinones
FDA EPC N0000175495 Oxazolidinone Antibacterial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011500 Protein Synthesis Inhibitors
CHEBI has role CHEBI:33231 antitubercular agent
CHEBI has role CHEBI:33281 antimicrobial agent
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:36047 antibacterial drug
CHEBI has role CHEBI:48001 protein synthesis inhibitor

Related Drugs by ATC class:

J01XX Other antibacterials 12 drugs
bacitracinclofoctoldaptomycinfosfomycingepotidacinlefamulinmandelic acidmethenaminenitroxolinespectinomycintedizolid phosphatexibornol

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Staphylococcal pneumonia indication 22754005
Pneumonia due to Streptococcus indication 34020007
Vancomycin resistant enterococcus indication 113727004
Streptococcus pyogenes infection indication 302809008
Infection due to Staphylococcus aureus indication 406602003
Complicated Skin and Skin Structure Staphylococcus Aureus Infection indication
Diabetic Foot Infection Due to Gram-Positive Bacteria indication
Complicated Skin and Skin Structure Streptococcus Agalactiae Infection indication
Complicated Skin and Skin Structure Streptococcus Pyogenes Infection indication
Vancomycin-Resistant Enterococcus Faecium Infection indication
Pyrexia of unknown origin off-label use 7520000
Infection of bone off-label use 111253001
Carcinoid syndrome contraindication 35868009
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of optic nerve contraindication 77157004 DOID:1891
Leukopenia contraindication 84828003 DOID:615
Thyrotoxicosis contraindication 90739004 DOID:7997
Lactic acidosis contraindication 91273001 DOID:3650
Pancytopenia contraindication 127034005 DOID:12450
Seizure disorder contraindication 128613002
Anemia contraindication 271737000 DOID:2355
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Peripheral nerve disease contraindication 302226006
Pheochromocytoma contraindication 302835009
Bone marrow depression contraindication 307762000
Serotonin syndrome contraindication 371089000
Visual impairment contraindication 397540003
Pseudomembranous enterocolitis contraindication 397683000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.4 acidic
pKa2 1.59 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Amine oxidase [flavin-containing] B Enzyme Ki 4.50 WOMBAT-PK
Amine oxidase [flavin-containing] A Enzyme Ki 5.10 CHEMBL
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Enzyme IC50 5.09 CHEMBL
Calmodulin-like protein 3 Cytosolic other IC50 5.03 CHEMBL
Amine oxidase [flavin-containing] B Enzyme IC50 4.77 CHEMBL

External reference:

IDSource
4021218 VUID
N0000148664 NUI
D00947 KEGG_DRUG
4021218 VANDF
C0663241 UMLSCUI
CHEBI:63607 CHEBI
ZLD PDB_CHEM_ID
CHEMBL126 ChEMBL_ID
DB00601 DRUGBANK_ID
D000069349 MESH_DESCRIPTOR_UI
441401 PUBCHEM_CID
10827 IUPHAR_LIGAND_ID
7584 INN_ID
ISQ9I6J12J UNII
190376 RXNORM
229070 MMSL
31932 MMSL
8840 MMSL
d04534 MMSL
008223 NDDF
125695009 SNOMEDCT_US
387056004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Zyvox HUMAN PRESCRIPTION DRUG LABEL 1 0009-4992 INJECTION, SOLUTION 600 mg INTRAVENOUS NDA 30 sections
Zyvox HUMAN PRESCRIPTION DRUG LABEL 1 0009-5136 GRANULE, FOR SUSPENSION 100 mg ORAL NDA 32 sections
Zyvox HUMAN PRESCRIPTION DRUG LABEL 1 0009-5136 GRANULE, FOR SUSPENSION 100 mg ORAL NDA 32 sections
Zyvox HUMAN PRESCRIPTION DRUG LABEL 1 0009-5137 INJECTION, SOLUTION 200 mg INTRAVENOUS NDA 32 sections
Zyvox HUMAN PRESCRIPTION DRUG LABEL 1 0009-5137 INJECTION, SOLUTION 200 mg INTRAVENOUS NDA 32 sections
Zyvox HUMAN PRESCRIPTION DRUG LABEL 1 0009-5138 TABLET, FILM COATED 600 mg ORAL NDA 32 sections
Zyvox HUMAN PRESCRIPTION DRUG LABEL 1 0009-5138 TABLET, FILM COATED 600 mg ORAL NDA 32 sections
Zyvox HUMAN PRESCRIPTION DRUG LABEL 1 0009-5140 INJECTION, SOLUTION 600 mg INTRAVENOUS NDA 32 sections
Zyvox HUMAN PRESCRIPTION DRUG LABEL 1 0009-5140 INJECTION, SOLUTION 600 mg INTRAVENOUS NDA 32 sections
Zyvox HUMAN PRESCRIPTION DRUG LABEL 1 0009-7807 INJECTION, SOLUTION 600 mg INTRAVENOUS NDA 32 sections
Zyvox HUMAN PRESCRIPTION DRUG LABEL 1 0009-7807 INJECTION, SOLUTION 600 mg INTRAVENOUS NDA 32 sections
Linezolid HUMAN PRESCRIPTION DRUG LABEL 1 0054-0319 POWDER, FOR SUSPENSION 100 mg ORAL ANDA 27 sections
Linezolid HUMAN PRESCRIPTION DRUG LABEL 1 0143-9534 INJECTION, SOLUTION 600 mg INTRAVENOUS ANDA 29 sections
Linezolid HUMAN PRESCRIPTION DRUG LABEL 1 0409-4883 INJECTION, SOLUTION 2 mg INTRAVENOUS NDA 32 sections
Linezolid HUMAN PRESCRIPTION DRUG LABEL 1 0781-3431 INJECTION, SOLUTION 200 mg INTRAVENOUS ANDA 29 sections
Linezolid HUMAN PRESCRIPTION DRUG LABEL 1 0781-3433 INJECTION, SOLUTION 600 mg INTRAVENOUS ANDA 29 sections
Linezolid Human Prescription Drug Label 1 0904-6553 TABLET, FILM COATED 600 mg ORAL ANDA 28 sections
Linezolid Human Prescription Drug Label 1 0904-6553 TABLET, FILM COATED 600 mg ORAL ANDA 28 sections
Zyvox HUMAN PRESCRIPTION DRUG LABEL 1 21695-399 TABLET, FILM COATED 600 mg ORAL NDA 28 sections
Linezolid HUMAN PRESCRIPTION DRUG LABEL 1 31722-749 TABLET, FILM COATED 600 mg ORAL ANDA 28 sections
Linezolid HUMAN PRESCRIPTION DRUG LABEL 1 31722-865 GRANULE, FOR SUSPENSION 100 mg ORAL ANDA 28 sections
Linezolid Human Prescription Drug Label 1 33342-352 TABLET, COATED 600 mg ORAL ANDA 29 sections
Linezolid HUMAN PRESCRIPTION DRUG LABEL 1 40032-022 TABLET 600 mg ORAL ANDA 26 sections
Linezolid HUMAN PRESCRIPTION DRUG LABEL 1 43386-022 TABLET 600 mg ORAL ANDA 26 sections
Linezolid Human Prescription Drug Label 1 46708-183 TABLET, FILM COATED 600 mg ORAL ANDA 27 sections
Linezolid Human Prescription Drug Label 1 55150-242 INJECTION, SOLUTION 600 mg INTRAVENOUS ANDA 28 sections
Zyvox HUMAN PRESCRIPTION DRUG LABEL 1 55695-009 SUSPENSION 100 mg ORAL NDA 31 sections
Linezolid HUMAN PRESCRIPTION DRUG LABEL 1 57664-682 INJECTION, SOLUTION 200 mg INTRAVENOUS ANDA 30 sections
Linezolid HUMAN PRESCRIPTION DRUG LABEL 1 57664-683 INJECTION, SOLUTION 600 mg INTRAVENOUS ANDA 30 sections
Linezolid HUMAN PRESCRIPTION DRUG LABEL 1 59762-1307 TABLET, FILM COATED 600 mg ORAL NDA authorized generic 32 sections