lidocaine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
local anaesthetics 1579 137-58-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lignocaine
  • lidocaine
  • xylocain
  • dalcaine
  • duncaine
  • esracaine
  • solarcaine
  • lidocaine hydrochloride
  • lidocaine hydrochloride anhydrous
  • lidocaine hydrochloride hydrate
  • lidocaine HCl
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
  • Molecular weight: 234.34
  • Formula: C14H22N2O
  • CLOGP: 1.95
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 32.34
  • ALOGS: -2.60
  • ROTB: 5
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
3 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 3.58 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 18.29 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 35 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.80 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 16 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.33 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.60 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.665 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.406 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 42.267 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 45.814 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 46.670 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 64.690 % High 1
herg hERG pIC50 4.592 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 3.882 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 10.447 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 51.090 % High 1
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,MAPK7,MAPKAPK2,NTRK2,PDK2,PDK4,PIK3CB,PRKDC,SIK2,SIK3,STK33,TEK 27
kinase-selectivity-class AXL,BRAF,DDR1,GRK2,PDK4 5
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.689 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.304 High 1
mh-clint Mouse hepatocyte intrinsic clearance 91.833 High 1
mppb Mouse plasma protein binding (% unbound) 66.310 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.897 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 1
pppb Pig plasma protein binding (% unbound) 60.880 % High 1
rat-kpuu-brain Rat brain Kpuu 0.656 % High 1
rh-clint Rat hepatocyte intrinsic clearance 115.611 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 90.260 % High 1
rppb Rat plasma protein binding (% unbound) 62.620 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 944.061 uM High 1

Approvals:

DateAgencyCompanyOrphan
Nov. 19, 1948 FDA FRESENIUS KABI USA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Product adhesion issue 1134.50 9.04 385 133492 4757 90489813
Local anaesthetic systemic toxicity 1080.47 9.04 338 133539 3162 90491408
Anaphylactic shock 416.16 9.04 357 133520 31260 90463310
Pemphigus 403.18 9.04 19 133858 326845 90167725
Hand deformity 383.31 9.04 12 133865 296350 90198220
Anaphylactic reaction 363.29 9.04 541 133336 86983 90407587
Macular degeneration 362.01 9.04 358 133519 37612 90456958
Maternal exposure during delivery 359.93 9.04 154 133723 3692 90490878
Glossodynia 357.73 9.04 32 133845 321747 90172823
Synovitis 352.93 9.04 38 133839 329714 90164856
Systemic lupus erythematosus 346.41 9.04 59 133818 361837 90132733
Contraindicated product administered 327.50 9.04 43 133834 320096 90174474
Anti-cyclic citrullinated peptide antibody positive 300.65 9.04 11 133866 236422 90258148
Pericarditis 297.19 9.04 28 133849 270123 90224447
Hepatic enzyme increased 296.31 9.04 83 133794 360653 90133917
Duodenal ulcer perforation 275.60 9.04 12 133865 221276 90273294
Cardiac arrest 273.42 9.04 527 133350 104408 90390162
Joint swelling 265.27 9.04 213 133664 503087 89991483
Toxic anterior segment syndrome 264.37 9.04 106 133771 2144 90492426
Product quality issue 261.05 9.04 441 133436 78884 90415686
Arthropathy 254.89 9.04 111 133766 366131 90128439
Helicobacter infection 243.00 9.04 26 133851 226824 90267746
Anaesthetic complication 234.96 9.04 100 133777 2365 90492205
Hypotension 234.50 9.04 1027 132850 324370 90170200
Infusion site pain 233.91 9.04 210 133667 19528 90475042
Folliculitis 233.42 9.04 18 133859 204335 90290235
Alopecia 231.60 9.04 234 133643 494837 89999733
Wound 230.33 9.04 80 133797 302900 90191670
Methaemoglobinaemia 217.20 9.04 110 133767 3905 90490665
Drug intolerance 208.80 9.04 212 133665 447379 90047191
Infusion site swelling 206.54 9.04 157 133720 11563 90483007
Rheumatoid factor positive 205.17 9.04 12 133865 171638 90322932
General physical health deterioration 186.06 9.04 151 133726 354964 90139606
Rheumatic fever 185.18 9.04 10 133867 153111 90341459
Psoriatic arthropathy 182.85 9.04 55 133822 228280 90266290
Muscle injury 182.30 9.04 23 133854 176631 90317939
Infusion site erythema 179.13 9.04 154 133723 13516 90481054
Abdominal discomfort 173.77 9.04 273 133604 477055 90017515
Impaired healing 170.91 9.04 66 133811 234133 90260437
Chronic sinusitis 169.19 9.04 192 133685 23610 90470960
Type 2 diabetes mellitus 162.65 9.04 49 133828 203195 90291375
Generalised tonic-clonic seizure 162.63 9.04 228 133649 34675 90459895
Kounis syndrome 162.08 9.04 78 133799 2475 90492095
Stress cardiomyopathy 162.03 9.04 144 133733 13211 90481359
Liver injury 152.06 9.04 33 133844 170534 90324036
Paraesthesia oral 149.28 9.04 208 133669 31451 90463119
Sleep disorder due to general medical condition, insomnia type 142.35 9.04 13 133864 128681 90365889
Therapeutic product effect decreased 140.45 9.04 122 133755 277449 90217121
Seizure 140.34 9.04 520 133357 152109 90342461
Treatment failure 138.18 9.04 147 133730 303781 90190789
Swollen joint count increased 135.28 9.04 7 133870 111199 90383371
Procedural pain 135.17 9.04 204 133673 33156 90461414
Irritable bowel syndrome 134.78 9.04 69 133808 207379 90287191
Drug ineffective for unapproved indication 134.00 9.04 301 133576 66343 90428227
Rheumatoid arthritis 132.25 9.04 207 133670 362407 90132163
Lagophthalmos 130.83 9.04 42 133835 430 90494140
Insurance issue 130.65 9.04 117 133760 10841 90483729
C-reactive protein abnormal 130.47 9.04 17 133860 127412 90367158
Bradycardia 130.41 9.04 343 133534 83504 90411066
Sinusitis 127.12 9.04 905 132972 342183 90152387
Infusion site extravasation 126.56 9.04 112 133765 10216 90484354
Infusion site pruritus 124.47 9.04 93 133784 6672 90487898
Ill-defined disorder 123.88 9.04 59 133818 184832 90309738
Toxicity to various agents 122.60 9.04 786 133091 287060 90207510
Swelling 121.35 9.04 275 133602 418783 90075787
Infusion site haemorrhage 119.26 9.04 83 133794 5328 90489242
Sedation complication 117.58 9.04 135 133742 16809 90477761
Lower respiratory tract infection 117.57 9.04 118 133759 250541 90244029
Radiculopathy 112.81 9.04 138 133739 18367 90476203
Vaginal flatulence 112.78 9.04 115 133762 12523 90482047
Facet joint syndrome 111.37 9.04 9 133868 98380 90396190
Lip dry 106.96 9.04 12 133865 100943 90393627
Female genital tract fistula 105.30 9.04 131 133746 17737 90476833
Blood cholesterol increased 102.11 9.04 94 133783 207918 90286652
Infusion site bruising 100.92 9.04 69 133808 4303 90490267
Erythema 100.67 9.04 631 133246 228615 90265955
Completed suicide 99.16 9.04 45 133832 145013 90349557
Proctitis 98.26 9.04 117 133760 15142 90479428
Pulseless electrical activity 97.94 9.04 91 133786 8841 90485729
Creatinine renal clearance decreased 97.93 9.04 130 133747 18769 90475801
Constipation 96.00 9.04 726 133151 279669 90214901
Musculoskeletal stiffness 95.56 9.04 183 133694 296349 90198221
Blister 95.39 9.04 143 133734 254855 90239715
Urinary tract infection 95.09 9.04 774 133103 304858 90189712
Depressed level of consciousness 94.67 9.04 279 133598 72505 90422065
Anaesthetic complication neurological 94.36 9.04 37 133840 704 90493866
Procedural hypotension 92.92 9.04 46 133831 1554 90493016
Peripheral venous disease 91.41 9.04 9 133868 83912 90410658
Pulse absent 91.32 9.04 74 133803 5981 90488589
Hypersensitivity 90.67 9.04 355 133522 454322 90040248
Apnoea 88.29 9.04 88 133789 9326 90485244
Illness 87.11 9.04 293 133584 81676 90412894
Bursitis 86.67 9.04 43 133834 131611 90362959
Inflammation 86.12 9.04 82 133795 178510 90316060
Vaginal discharge 86.02 9.04 124 133753 19340 90475230
Unresponsive to stimuli 85.54 9.04 180 133697 37941 90456629
Corneal oedema 82.65 9.04 45 133832 1856 90492714
Grip strength decreased 82.31 9.04 18 133859 92558 90402012
Discomfort 81.83 9.04 177 133700 274158 90220412
Ventricular tachycardia 80.75 9.04 137 133740 24571 90469999
Body tinea 80.18 9.04 46 133831 2102 90492468
Sulphaemoglobinaemia 80.00 9.04 30 133847 503 90494067
Sleep disorder 79.06 9.04 106 133771 197924 90296646
Dermatitis contact 79.04 9.04 99 133778 13496 90481074
Systemic toxicity 78.31 9.04 25 133852 251 90494319
Stomatitis 76.45 9.04 184 133693 274514 90220056
Deep vein thrombosis postoperative 76.07 9.04 8 133869 70801 90423769
Blood calcium decreased 75.40 9.04 149 133728 30033 90464537
Bronchospasm 74.63 9.04 120 133757 20589 90473981
Gait inability 74.48 9.04 64 133813 146392 90348178
Oral candidiasis 73.35 9.04 162 133715 35293 90459277
Incorrect drug administration rate 72.85 9.04 61 133816 5162 90489408
Wound infection 72.73 9.04 33 133844 106369 90388201
Arthralgia 71.69 9.04 770 133107 777752 89716818
Embolia cutis medicamentosa 71.10 9.04 29 133848 614 90493956
Condition aggravated 70.40 9.04 553 133324 594992 89899578
C-reactive protein increased 68.51 9.04 101 133776 181288 90313282
Type I hypersensitivity 67.41 9.04 53 133824 4102 90490468
Bronchitis 67.13 9.04 421 133456 152506 90342064
Joint range of motion decreased 66.90 9.04 61 133816 135582 90358988
Fibromyalgia 66.68 9.04 127 133750 206142 90288428
Peripheral swelling 66.48 9.04 349 133528 412757 90081813
COVID-19 66.31 9.04 452 133425 168391 90326179
Staphylococcal infection 66.18 9.04 189 133688 48250 90446320
Abdominal pain upper 66.10 9.04 260 133617 332414 90162156
Phrenic nerve paralysis 64.81 9.04 23 133854 327 90494243
Ventricular fibrillation 64.31 9.04 91 133786 13953 90480617
Adjustment disorder with depressed mood 62.04 9.04 6 133871 56747 90437823
Infusion site nodule 61.92 9.04 36 133841 1687 90492883
Seasonal allergy 61.74 9.04 117 133760 22866 90471704
Inhibitory drug interaction 61.60 9.04 45 133832 3118 90491452
Knee arthroplasty 61.37 9.04 23 133854 83159 90411411
Respiratory tract infection 60.85 9.04 209 133668 58869 90435701
Night sweats 59.90 9.04 61 133816 128705 90365865
Pulmonary fibrosis 59.68 9.04 43 133834 107460 90387110
Product use issue 59.27 9.04 268 133609 329651 90164919
Administration site erythema 58.39 9.04 28 133849 881 90493689
Tracheal deviation 58.27 9.04 20 133857 256 90494314
Creatinine renal clearance increased 57.91 9.04 44 133833 3237 90491333
Hypercholesterolaemia 57.80 9.04 39 133838 100853 90393717
Extradural abscess 57.06 9.04 31 133846 1273 90493297
Infusion site mass 56.42 9.04 37 133840 2152 90492418
Liver disorder 55.79 9.04 58 133819 121211 90373359
Sedation 55.49 9.04 177 133700 47994 90446576
Blepharospasm 55.32 9.04 8 133869 55437 90439133
Infusion site discharge 55.19 9.04 38 133839 2397 90492173
Infection susceptibility increased 55.07 9.04 46 133831 3880 90490690
Mental status changes 55.00 9.04 168 133709 44511 90450059
Prescribed underdose 54.92 9.04 21 133856 74998 90419572
Upper respiratory tract infection 54.91 9.04 351 133526 127967 90366603
Infusion site urticaria 54.25 9.04 33 133844 1682 90492888
Loss of consciousness 54.21 9.04 374 133503 139864 90354706
Emotional distress 53.98 9.04 147 133730 36515 90458055
Wheezing 53.97 9.04 176 133701 237904 90256666
Hip arthroplasty 53.08 9.04 23 133854 76185 90418385
Red blood cell sedimentation rate increased 51.38 9.04 29 133848 82566 90412004
Confusional state 51.17 9.04 347 133530 385858 90108712
Gastrointestinal disorder 50.72 9.04 201 133676 256486 90238084
Status epilepticus 50.59 9.04 96 133781 18778 90475792
Post procedural complication 49.99 9.04 96 133781 18946 90475624
Infusion site rash 49.89 9.04 36 133841 2447 90492123
Nail disorder 49.52 9.04 13 133864 59054 90435516
Administration site pain 48.54 9.04 27 133850 1162 90493408
Tachycardia 48.26 9.04 398 133479 157275 90337295
Administration site swelling 47.82 9.04 29 133848 1470 90493100
Bone erosion 47.76 9.04 10 133867 53011 90441559
Cauda equina syndrome 47.65 9.04 28 133849 1339 90493231
Orthostatic hypotension 47.55 9.04 153 133724 41674 90452896
Musculoskeletal pain 47.38 9.04 115 133762 171136 90323434
Back pain 47.37 9.04 694 133183 316481 90178089
Pneumocephalus 47.25 9.04 17 133860 252 90494318
Rash 46.93 9.04 861 133016 795239 89699331
Prescribed overdose 46.84 9.04 45 133832 97580 90396990
Circulatory collapse 46.20 9.04 109 133768 24795 90469775
Cellulitis 46.19 9.04 261 133616 91076 90403494
Paraplegia 45.84 9.04 39 133838 3373 90491197
Headache 45.52 9.04 1628 132249 861118 89633452
Chills 45.25 9.04 342 133535 131639 90362931
Onychomadesis 45.05 9.04 7 133870 45991 90448579
Vascular malformation 44.80 9.04 22 133855 730 90493840
Sinus tachycardia 44.68 9.04 117 133760 28396 90466174
Obesity 44.66 9.04 54 133823 105453 90389117
Lung disorder 44.41 9.04 97 133780 149786 90344784
Psoriasis 44.30 9.04 95 133782 147659 90346911
Lupus vulgaris 43.81 9.04 7 133870 45052 90449518
Colitis 43.74 9.04 212 133665 69730 90424840
Adverse event 43.72 9.04 66 133811 117352 90377218
Paranasal cyst 43.25 9.04 22 133855 788 90493782
Multiple allergies 43.05 9.04 79 133798 15067 90479503
Glucose tolerance impaired 43.03 9.04 56 133821 7929 90486641
Renal function test abnormal 42.82 9.04 53 133824 7138 90487432
Fear 42.66 9.04 83 133794 16539 90478031
Hepatic cirrhosis 42.63 9.04 20 133857 63233 90431337
Meningitis chemical 42.19 9.04 16 133861 277 90494293
Bundle branch block left 42.03 9.04 55 133822 7830 90486740
Foetal exposure during delivery 41.54 9.04 17 133860 363 90494207
Product dose omission issue 41.12 9.04 632 133245 291055 90203515
Inappropriate schedule of product administration 40.92 9.04 369 133508 149564 90345006
Respiratory depression 40.25 9.04 78 133799 15497 90479073
Hypoaesthesia oral 40.16 9.04 78 133799 15522 90479048
Purtscher retinopathy 40.16 9.04 13 133864 137 90494433
Drug-induced liver injury 39.54 9.04 45 133832 90273 90404297
Nystagmus 39.44 9.04 51 133826 7176 90487394
Extradural haematoma 39.32 9.04 29 133848 2039 90492531
Paralysis 39.31 9.04 65 133812 11413 90483157
Ophthalmoplegia 38.95 9.04 27 133850 1722 90492848
Endophthalmitis 38.87 9.04 41 133836 4644 90489926
Lower limb fracture 38.71 9.04 41 133836 84972 90409598
Dry mouth 38.37 9.04 141 133736 183918 90310652
Acute motor-sensory axonal neuropathy 38.37 9.04 16 133861 359 90494211
Diplopia 38.22 9.04 111 133766 28603 90465967
Osteoarthritis 38.19 9.04 154 133723 195576 90298994
Weight increased 38.09 9.04 414 133463 417513 90077057
Mobility decreased 37.99 9.04 216 133661 250518 90244052
Poor quality sleep 37.34 9.04 100 133777 24593 90469977
Retinitis 37.33 9.04 6 133871 38452 90456118
Autoimmune disorder 37.26 9.04 35 133842 76709 90417861
Blood pressure decreased 37.20 9.04 213 133664 74682 90419888
Application site rash 36.87 9.04 31 133846 2638 90491932
Neurotoxicity 36.66 9.04 91 133786 21376 90473194
Anterior chamber cell 36.44 9.04 19 133858 717 90493853
Peripheral nerve injury 36.37 9.04 19 133858 720 90493850
Cognitive disorder 36.20 9.04 200 133677 69207 90425363
Otitis media 36.14 9.04 44 133833 5826 90488744
Cyanosis 35.92 9.04 85 133792 19370 90475200
Infusion site warmth 35.80 9.04 28 133849 2150 90492420
Hypoxia 35.37 9.04 205 133672 72194 90422376
Hypopyon 35.26 9.04 20 133857 894 90493676
Infusion site irritation 35.19 9.04 23 133854 1330 90493240
Eyelid ptosis 34.96 9.04 54 133823 8952 90485618
Spinal epidural haemorrhage 34.74 9.04 14 133863 287 90494283
Arthritis bacterial 33.73 9.04 48 133829 7397 90487173
Application site erythema 33.64 9.04 40 133837 5168 90489402
Platelet aggregation inhibition 33.41 9.04 12 133865 177 90494393
Loss of personal independence in daily activities 33.40 9.04 97 133780 136008 90358562
Spinal epidural haematoma 33.05 9.04 22 133855 1312 90493258
Hyperlipidaemia 32.85 9.04 91 133786 22825 90471745
Respiratory arrest 32.70 9.04 116 133761 33195 90461375
Mydriasis 32.65 9.04 70 133807 14942 90479628
Overdose 31.92 9.04 365 133512 157344 90337226
Septic arthritis staphylococcal 31.77 9.04 16 133861 561 90494009
Product distribution issue 31.77 9.04 33 133844 3672 90490898
Hepatotoxicity 31.66 9.04 14 133863 45828 90448742
Visual acuity reduced 31.64 9.04 91 133786 23319 90471251
Vitritis 31.52 9.04 23 133854 1591 90492979
Kidney infection 31.48 9.04 97 133780 25819 90468751
Incorrect route of product administration 31.33 9.04 153 133724 50473 90444097
Infusion site discomfort 31.28 9.04 24 133853 1792 90492778
Hepatitis 31.23 9.04 35 133842 70704 90423866
Hyperthermia malignant 31.18 9.04 21 133856 1277 90493293
Meningitis aseptic 31.18 9.04 44 133833 6729 90487841
Infusion related reaction 31.10 9.04 431 133446 416349 90078221
Brain stem syndrome 31.09 9.04 17 133860 707 90493863
Mastoiditis 30.82 9.04 23 133854 1647 90492923
Balance disorder 30.74 9.04 247 133630 96833 90397737
Maternal exposure during pregnancy 30.70 9.04 362 133515 359701 90134869
Removal of foreign body 30.64 9.04 7 133870 15 90494555
Spinal cord compression 30.54 9.04 37 133840 4874 90489696
Ear infection 30.54 9.04 192 133685 69583 90424987
Pallor 30.20 9.04 115 133762 34050 90460520
Vocal cord dysfunction 29.97 9.04 18 133859 896 90493674
Procedural complication 29.79 9.04 40 133837 5838 90488732
Application site irritation 29.65 9.04 24 133853 1937 90492633
Stridor 29.63 9.04 36 133841 4757 90489813
Anhedonia 29.24 9.04 57 133820 11374 90483196
Sinobronchitis 28.84 9.04 16 133861 685 90493885
Retinal artery occlusion 28.57 9.04 25 133852 2246 90492324
Bursitis infective 28.32 9.04 21 133856 1489 90493081
C-reactive protein 28.08 9.04 6 133871 31361 90463209
Intentional product use issue 27.64 9.04 197 133680 216695 90277875
Liver function test increased 27.62 9.04 52 133825 84803 90409767
Infection 27.17 9.04 374 133503 361720 90132850
Abortion spontaneous 27.01 9.04 24 133853 54032 90440538
Rectal haemorrhage 27.01 9.04 212 133665 82532 90412038
Underdose 26.97 9.04 24 133853 53993 90440577
Fear of eating 26.82 9.04 13 133864 419 90494151
Gastroenteritis viral 26.68 9.04 102 133775 30253 90464317
Purpura 26.68 9.04 64 133813 14714 90479856
Anaphylactoid shock 26.65 9.04 13 133864 425 90494145
Schizencephaly 26.49 9.04 12 133865 331 90494239
Cerebral haemorrhage foetal 26.32 9.04 12 133865 336 90494234
Aqueous fibrin 26.31 9.04 9 133868 114 90494456
Nerve root injury 26.14 9.04 8 133869 69 90494501
Allergic sinusitis 26.06 9.04 23 133854 2090 90492480
Nausea 26.04 9.04 1939 131938 1108377 89386193
Cardio-respiratory arrest 25.95 9.04 171 133706 62969 90431601
Unevaluable event 25.95 9.04 154 133723 54694 90439876
Tenderness 25.89 9.04 93 133784 26775 90467795
Sciatica 25.79 9.04 71 133806 101311 90393259
Retinal vasculitis 25.74 9.04 20 133857 1521 90493049
Nerve block 25.72 9.04 16 133861 849 90493721
Skin infection 25.67 9.04 71 133806 17793 90476777
Trigeminal palsy 25.64 9.04 8 133869 74 90494496
Corneal epithelium defect 25.25 9.04 13 133864 478 90494092
Lupus-like syndrome 25.25 9.04 21 133856 48825 90445745
Memory impairment 25.21 9.04 179 133698 197065 90297505
Anaphylactoid reaction 25.12 9.04 32 133845 4436 90490134
Spinal anaesthesia 24.91 9.04 8 133869 82 90494488
Onychomycosis 24.90 9.04 12 133865 37364 90457206
Renal injury 24.90 9.04 50 133827 10193 90484377
Impaired quality of life 24.81 9.04 83 133794 23061 90471509
Road traffic accident 24.76 9.04 79 133798 107547 90387023
Neonatal toxicity 24.66 9.04 7 133870 45 90494525
Epilepsy 24.51 9.04 53 133824 82153 90412417
Epidural haemorrhage 24.29 9.04 11 133866 303 90494267
Urticaria thermal 24.24 9.04 13 133864 520 90494050
Quadriparesis 24.22 9.04 24 133853 2525 90492045
Agitation 24.20 9.04 176 133701 66922 90427648
Localised infection 24.14 9.04 106 133771 33456 90461114
Parophthalmia 24.09 9.04 12 133865 411 90494159
Anal skin tags 23.89 9.04 14 133863 666 90493904
Foot deformity 23.72 9.04 32 133845 59619 90434951
Haemorrhoids 23.70 9.04 90 133787 26612 90467958
Laryngeal oedema 23.61 9.04 39 133838 6842 90487728
Sopor 23.58 9.04 4 133873 24640 90469930
Monoplegia 23.37 9.04 28 133849 3646 90490924
Device infusion issue 23.35 9.04 24 133853 2638 90491932
Dysarthria 23.27 9.04 149 133728 54333 90440237
Sensory loss 23.22 9.04 69 133808 18006 90476564
Wrong product administered 23.08 9.04 41 133836 7624 90486946
Multiple drug therapy 23.08 9.04 39 133838 6970 90487600
Skin warm 23.00 9.04 41 133836 7646 90486924
Red blood cell sedimentation rate abnormal 23.00 9.04 4 133873 24200 90470370
Back injury 22.94 9.04 21 133856 46601 90447969
Injury 22.89 9.04 184 133693 197165 90297405
Administration site extravasation 22.83 9.04 17 133860 1213 90493357
Arthritis 22.79 9.04 149 133728 167166 90327404
Infusion site scar 22.68 9.04 13 133864 593 90493977
Fall 22.62 9.04 898 132979 480912 90013658
Myopathy toxic 22.52 9.04 13 133864 601 90493969
Product contamination microbial 22.07 9.04 10 133867 276 90494294
Coeliac disease 22.06 9.04 20 133857 44590 90449980
Viral infection 22.04 9.04 120 133757 41294 90453276
Vitamin D increased 22.00 9.04 15 133862 931 90493639
Premature delivery 21.77 9.04 114 133763 38648 90455922
Application site vesicles 21.75 9.04 18 133859 1499 90493071
Drug resistance 21.50 9.04 9 133868 30440 90464130
Central pain syndrome 21.47 9.04 13 133864 657 90493913
Suicide attempt 21.35 9.04 50 133827 75349 90419221
Skin disorder 21.34 9.04 109 133768 36597 90457973
Airway peak pressure increased 21.30 9.04 11 133866 407 90494163
Acute respiratory failure 21.27 9.04 122 133755 42796 90451774
Soft tissue atrophy 21.08 9.04 6 133871 39 90494531
Medical device site cellulitis 20.98 9.04 9 133868 217 90494353
Economic problem 20.86 9.04 25 133852 3256 90491314
Diarrhoea 20.85 9.04 1155 132722 938035 89556535
Upper airway obstruction 20.82 9.04 15 133862 1017 90493553
Application site discomfort 20.81 9.04 11 133866 427 90494143
Ventricular hypokinesia 20.70 9.04 32 133845 5309 90489261
Taste disorder 20.66 9.04 37 133840 61509 90433061
Stress 20.53 9.04 197 133680 81198 90413372
Oral herpes 20.52 9.04 101 133776 33423 90461147
Atonic urinary bladder 20.51 9.04 8 133869 150 90494420
Drug tolerance decreased 20.39 9.04 11 133866 32119 90462451
Ventricular extrasystoles 20.38 9.04 54 133823 13196 90481374
Intentional self-injury 20.19 9.04 9 133868 29325 90465245
Accidental overdose 20.11 9.04 89 133788 28184 90466386
Diplegia 20.11 9.04 17 133860 1458 90493112
Infusion site discolouration 20.10 9.04 15 133862 1074 90493496
Vitamin B12 deficiency 19.97 9.04 38 133839 7448 90487122
Epidural analgesia 19.90 9.04 8 133869 163 90494407
Electrocardiogram ST segment elevation 19.85 9.04 27 133850 3989 90490581
Procedure aborted 19.67 9.04 8 133869 168 90494402
Tooth infection 19.59 9.04 70 133807 20100 90474470
Foetal heart rate abnormal 19.45 9.04 14 133863 948 90493622
Infusion site induration 19.29 9.04 17 133860 1542 90493028
Shock 19.28 9.04 89 133788 28689 90465881
Neuromuscular block prolonged 19.23 9.04 12 133865 640 90493930
Environmental exposure 19.14 9.04 7 133870 109 90494461
Tremor 18.99 9.04 325 133552 152848 90341722
Product contamination 18.99 9.04 15 133862 1169 90493401
Therapy partial responder 18.50 9.04 73 133804 21970 90472600
Immunodeficiency 18.43 9.04 22 133855 43212 90451358
Influenza like illness 18.34 9.04 191 133686 80420 90414150
Poor venous access 18.32 9.04 67 133810 19460 90475110
Cancer pain 18.31 9.04 26 133851 3999 90490571
Medical device site abscess 18.27 9.04 8 133869 203 90494367
Arthritis infective 18.23 9.04 38 133839 7954 90486616
Intentional overdose 18.18 9.04 74 133803 93760 90400810
Joint stiffness 18.15 9.04 57 133820 77985 90416585
Cardiogenic shock 18.15 9.04 78 133799 24390 90470180
Infusion site infection 18.13 9.04 21 133856 2639 90491931
Thyroid atrophy 18.10 9.04 9 133868 307 90494263
Neutropenia 18.06 9.04 229 133648 224675 90269895
Foreign body in respiratory tract 17.99 9.04 9 133868 311 90494259
Inadequate analgesia 17.98 9.04 23 133854 3201 90491369
Neuralgia 17.94 9.04 93 133784 31407 90463163
Tinnitus 17.87 9.04 117 133760 42985 90451585
Impaired work ability 17.87 9.04 66 133811 19260 90475310
Arachnoiditis 17.83 9.04 11 133866 575 90493995
Trigemino-cardiac reflex 17.76 9.04 6 133871 73 90494497
Corneal abrasion 17.59 9.04 15 133862 1301 90493269
Skin discolouration 17.59 9.04 119 133758 44196 90450374
Haematochezia 17.57 9.04 171 133706 70742 90423828
Genital erosion 17.51 9.04 10 133867 453 90494117
Influenza 17.45 9.04 296 133581 138968 90355602
Apnoeic attack 17.40 9.04 9 133868 334 90494236
Administration site reaction 17.23 9.04 9 133868 341 90494229
Amnesia 17.23 9.04 92 133785 108413 90386157
Finger deformity 17.18 9.04 14 133863 32883 90461687
Cystitis 17.08 9.04 162 133715 66556 90428014
Punctate keratitis 17.05 9.04 12 133865 784 90493786
Eye infection 16.98 9.04 53 133824 14201 90480369
Infusion site oedema 16.90 9.04 14 133863 1167 90493403
Hypoproteinaemia 16.88 9.04 22 133855 3120 90491450
Nasopharyngitis 16.86 9.04 465 133412 406639 90087931
Neuromuscular blockade 16.85 9.04 9 133868 357 90494213
Mucosal erosion 16.85 9.04 17 133860 1828 90492742
Bacterial infection 16.83 9.04 74 133803 23370 90471200
Nerve injury 16.82 9.04 45 133832 11061 90483509
Nephrolithiasis 16.70 9.04 127 133750 48958 90445612
Meningitis 16.70 9.04 38 133839 8443 90486127
Bone density decreased 16.68 9.04 60 133817 17285 90477285
Thrombocytopenia 16.58 9.04 213 133664 208512 90286058
Aspiration joint abnormal 16.56 9.04 3 133874 0 90494570
Application site pain 16.53 9.04 27 133850 4693 90489877
Pneumonia mycoplasmal 16.50 9.04 13 133864 1009 90493561
Myelosuppression 16.44 9.04 34 133843 53557 90441013
Injection site atrophy 16.42 9.04 12 133865 832 90493738
Syncope 16.27 9.04 281 133596 132382 90362188
Glossoptosis 16.26 9.04 6 133871 96 90494474
Device expulsion 16.19 9.04 22 133855 40864 90453706
Cutis laxa 16.16 9.04 7 133870 173 90494397
Depression 16.14 9.04 330 133547 300271 90194299
Drug interaction 16.08 9.04 528 133349 275925 90218645
Eye movement disorder 15.97 9.04 31 133846 6167 90488403
Genital ulceration 15.94 9.04 13 133864 1060 90493510
Injection site necrosis 15.89 9.04 15 133862 1486 90493084
Asthenia 15.88 9.04 636 133241 533115 89961455
Axillary nerve injury 15.86 9.04 5 133872 48 90494522
Akinesia 15.86 9.04 16 133861 1720 90492850
Quadriplegia 15.86 9.04 18 133859 2213 90492357
Application site pruritus 15.84 9.04 25 133852 4222 90490348
Streptococcal infection 15.72 9.04 34 133843 7299 90487271
Respiratory distress 15.71 9.04 105 133772 38841 90455729
Tryptase increased 15.64 9.04 10 133867 557 90494013
Decreased appetite 15.61 9.04 430 133447 376110 90118460
Spinal cord oedema 15.59 9.04 7 133870 189 90494381
Polyarthritis 15.46 9.04 4 133873 18346 90476224
Hallucination, tactile 15.27 9.04 9 133868 433 90494137
Retinal haemorrhage 15.06 9.04 29 133848 5735 90488835
Gastric mucosa erythema 15.04 9.04 9 133868 445 90494125
Anaemia 15.04 9.04 651 133226 352151 90142419
Speech disorder 14.98 9.04 117 133760 45468 90449102
Conjunctival oedema 14.95 9.04 12 133865 957 90493613
Syringomyelia 14.91 9.04 7 133870 210 90494360
Application site burn 14.89 9.04 12 133865 962 90493608
Neonatal seizure 14.87 9.04 10 133867 607 90493963
Apgar score low 14.65 9.04 13 133864 1190 90493380
Propionibacterium infection 14.62 9.04 4 133873 22 90494548
Anterior chamber fibrin 14.58 9.04 6 133871 130 90494440
Product administration interrupted 14.47 9.04 46 133831 12446 90482124
Piloerection 14.45 9.04 10 133867 636 90493934
Vision blurred 14.39 9.04 236 133641 110057 90384513
Delayed recovery from anaesthesia 14.30 9.04 12 133865 1018 90493552
Proctalgia 14.26 9.04 35 133842 8163 90486407
Pneumothorax 14.14 9.04 61 133816 19106 90475464
Spinal cord infarction 14.14 9.04 8 133869 356 90494214
Heliotrope rash 14.10 9.04 7 133870 238 90494332
Eye infarction 13.97 9.04 5 133872 73 90494497
Procedural haemorrhage 13.95 9.04 20 133857 3104 90491466
Sepsis 13.91 9.04 356 133521 179458 90315112
Infantile apnoea 13.89 9.04 13 133864 1274 90493296
Injection site oedema 13.87 9.04 15 133862 1748 90492822
Lactic acidosis 13.86 9.04 34 133843 50429 90444141
Nail bed tenderness 13.86 9.04 8 133869 370 90494200
Spinal synovial cyst 13.78 9.04 5 133872 76 90494494
Scar 13.75 9.04 52 133825 15343 90479227
Cataract nuclear 13.68 9.04 12 133865 1082 90493488
Vascular stenosis 13.67 9.04 9 133868 527 90494043
Infusion site inflammation 13.58 9.04 9 133868 533 90494037
Anxiety 13.51 9.04 573 133304 309199 90185371
Facial paralysis 13.49 9.04 52 133825 15482 90479088
Transferrin decreased 13.47 9.04 8 133869 390 90494180
Electrocardiogram QRS complex shortened 13.43 9.04 9 133868 543 90494027
Spinal osteoarthritis 13.41 9.04 60 133817 19088 90475482
Liver function test abnormal 13.39 9.04 35 133842 50810 90443760
Incontinence 13.37 9.04 47 133830 13388 90481182
Nerve root injury cervical 13.27 9.04 3 133874 6 90494564
Tonic posturing 13.27 9.04 3 133874 6 90494564
Acute kidney injury 13.24 9.04 366 133511 320021 90174549
Body dysmorphic disorder 13.24 9.04 8 133869 403 90494167
Urinary incontinence 13.23 9.04 98 133779 37468 90457102
Oesophageal adenocarcinoma recurrent 13.23 9.04 4 133873 33 90494537
Supraventricular extrasystoles 13.19 9.04 26 133851 5231 90489339
Intraocular pressure increased 13.11 9.04 31 133846 7062 90487508
Inability to afford medication 13.07 9.04 21 133856 3601 90490969
Leukopenia 13.05 9.04 91 133786 100619 90393951
Implant site bruising 12.97 9.04 8 133869 418 90494152
Hemiplegic migraine 12.96 9.04 6 133871 174 90494396
Exostosis 12.93 9.04 38 133839 53096 90441474
Left ventricle outflow tract obstruction 12.87 9.04 8 133869 424 90494146
Retinal detachment 12.81 9.04 30 133847 6792 90487778
Autonomic neuropathy 12.76 9.04 13 133864 1414 90493156
Gastrooesophageal reflux disease 12.75 9.04 171 133706 166166 90328404
Incision site rash 12.73 9.04 4 133873 38 90494532
Device wireless communication issue 12.71 9.04 5 133872 96 90494474
Vulvovaginal swelling 12.58 9.04 10 133867 786 90493784
Vasoplegia syndrome 12.54 9.04 18 133859 2796 90491774
Herpes zoster 12.53 9.04 203 133674 94441 90400129
Product use in unapproved indication 12.51 9.04 612 133265 335624 90158946
Maternal exposure timing unspecified 12.46 9.04 9 133868 22474 90472096
Drug reaction with eosinophilia and systemic symptoms 12.39 9.04 28 133849 42730 90451840
Eyelid contusion 12.38 9.04 5 133872 103 90494467
Poikiloderma 12.38 9.04 7 133870 311 90494259
Allodynia 12.34 9.04 11 133866 1013 90493557
Uterine hypertonus 12.32 9.04 7 133870 314 90494256
Iron binding capacity total decreased 12.31 9.04 8 133869 458 90494112
Allergy to immunoglobulin therapy 12.28 9.04 6 133871 197 90494373
Walking aid user 12.23 9.04 21 133856 35485 90459085
Post procedural infection 12.13 9.04 40 133837 11034 90483536
Spondylitis 12.12 9.04 3 133874 14175 90480395
Myelitis transverse 12.08 9.04 13 133864 1507 90493063
Acute generalised exanthematous pustulosis 12.01 9.04 46 133831 13657 90480913
Intervertebral disc degeneration 12 9.04 54 133823 17220 90477350
Orbital infection 12.00 9.04 5 133872 112 90494458
Malabsorption from administration site 12.00 9.04 5 133872 112 90494458
Procedural anxiety 11.94 9.04 10 133867 846 90493724
Tooth abscess 11.93 9.04 52 133825 16361 90478209
Anal sphincter atony 11.89 9.04 7 133870 336 90494234
Rash vesicular 11.88 9.04 6 133871 18191 90476379
Foetal death 11.88 9.04 8 133869 20715 90473855
Foetal heart rate decreased 11.87 9.04 6 133871 212 90494358
Mean arterial pressure decreased 11.87 9.04 6 133871 212 90494358
Obstruction 11.84 9.04 21 133856 3900 90490670
Peripheral vascular disorder 11.77 9.04 28 133849 6403 90488167
Product administration error 11.74 9.04 73 133804 26350 90468220
Dysphagia 11.74 9.04 232 133645 112046 90382524
Calcinosis 11.66 9.04 17 133860 2678 90491892
Sleep disorder due to a general medical condition 11.63 9.04 31 133846 44707 90449863
Haemodynamic instability 11.62 9.04 41 133836 11698 90482872
Pupil fixed 11.59 9.04 15 133862 2113 90492457
Chemical burn 11.58 9.04 8 133869 507 90494063
Clonus 11.58 9.04 26 133851 5724 90488846
Intercepted medication error 11.54 9.04 10 133867 887 90493683
Colitis ulcerative 11.52 9.04 138 133739 60128 90434442
Dysphoria 11.48 9.04 27 133850 6127 90488443
Weight decreased 11.44 9.04 678 133199 379232 90115338
Neuroleptic malignant syndrome 11.43 9.04 4 133873 15092 90479478
Allergic cough 11.43 9.04 11 133866 1117 90493453
Floppy infant 11.42 9.04 5 133872 127 90494443
Electrocardiogram QRS complex prolonged 11.35 9.04 30 133847 7318 90487252
Somnolence 11.31 9.04 396 133481 208688 90285882
Disease progression 11.29 9.04 163 133714 156452 90338118
Food poisoning 11.29 9.04 24 133853 5094 90489476
Fibula agenesis 11.26 9.04 4 133873 57 90494513
Vaginal abscess 11.22 9.04 8 133869 534 90494036
Atelectasis 11.20 9.04 68 133809 24341 90470229
Spina bifida occulta 11.20 9.04 4 133873 58 90494512
Respiratory failure 11.17 9.04 241 133636 118177 90376393
Autoimmune thyroiditis 11.16 9.04 26 133851 5867 90488703
Large intestine benign neoplasm 11.13 9.04 5 133872 135 90494435
Vascular resistance systemic decreased 11.03 9.04 5 133872 138 90494432
Spinal stroke 11.01 9.04 4 133873 61 90494509
Skin laceration 10.99 9.04 71 133806 25964 90468606
Procedural nausea 10.95 9.04 11 133866 1177 90493393
Pulmonary oedema 10.94 9.04 140 133737 61940 90432630
Pupillary reflex impaired 10.93 9.04 16 133861 2529 90492041
Photophobia 10.89 9.04 61 133816 21208 90473362
Injection site ischaemia 10.89 9.04 3 133874 17 90494553
Tachypnoea 10.84 9.04 61 133816 21248 90473322
Administration site scar 10.84 9.04 4 133873 64 90494506
Cataract 10.84 9.04 158 133719 71934 90422636
Implant site swelling 10.83 9.04 8 133869 564 90494006
Chronic obstructive pulmonary disease 10.78 9.04 161 133716 73668 90420902
Hypoaesthesia 10.76 9.04 368 133509 313842 90180728
Vascular pseudoaneurysm 10.75 9.04 13 133864 1710 90492860
Frequent bowel movements 10.72 9.04 130 133747 56805 90437765
Myxoedema coma 10.71 9.04 7 133870 405 90494165
Vasospasm 10.70 9.04 10 133867 979 90493591
Device programming error 10.69 9.04 6 133871 263 90494307
Conduction disorder 10.67 9.04 13 133864 1722 90492848
Arthritis fungal 10.67 9.04 4 133873 67 90494503
Cough 10.65 9.04 656 133221 368306 90126264
Infusion site streaking 10.64 9.04 8 133869 579 90493991
No adverse event 10.62 9.04 150 133727 67832 90426738
Administration site irritation 10.62 9.04 4 133873 68 90494502
Neonatal respiratory acidosis 10.58 9.04 6 133871 268 90494302
Myalgia 10.57 9.04 336 133541 174789 90319781
Type IV hypersensitivity reaction 10.56 9.04 20 133857 3906 90490664
Vitreous haemorrhage 10.55 9.04 16 133861 2610 90491960
Blood pressure immeasurable 10.54 9.04 12 133865 1480 90493090
Disseminated intravascular coagulation 10.52 9.04 61 133816 21477 90473093
Injection site infection 10.51 9.04 15 133862 2317 90492253
Withdrawal syndrome 10.50 9.04 63 133814 22461 90472109
Laryngitis 10.49 9.04 39 133838 50714 90443856
Hallucination 10.49 9.04 146 133731 65813 90428757
Tricuspid valve repair 10.48 9.04 3 133874 20 90494550
Limb injury 10.43 9.04 81 133796 31427 90463143
Complex regional pain syndrome 10.40 9.04 16 133861 2643 90491927
Incision site swelling 10.38 9.04 6 133871 278 90494292
Intraocular pressure fluctuation 10.35 9.04 4 133873 73 90494497
Anaesthetic complication pulmonary 10.35 9.04 4 133873 73 90494497
Airway complication of anaesthesia 10.35 9.04 7 133870 429 90494141
Burning sensation 10.31 9.04 141 133736 63311 90431259
Product preparation error 10.30 9.04 36 133841 10225 90484345
Hyperaesthesia 10.27 9.04 37 133840 10665 90483905
Allergy to metals 10.27 9.04 10 133867 1030 90493540
Post procedural fever 10.26 9.04 7 133870 435 90494135
Cystoid macular oedema 10.20 9.04 14 133863 2086 90492484
Conjunctivitis 10.18 9.04 71 133806 26635 90467935
Chorea 10.15 9.04 14 133863 2096 90492474
Oropharyngeal pain 10.10 9.04 232 133645 114955 90379615
Muscle tightness 10.09 9.04 43 133834 13396 90481174
Myasthenia gravis crisis 10.08 9.04 10 133867 1054 90493516
Sensitive skin 10.07 9.04 18 133859 3363 90491207
Infusion site vesicles 10.03 9.04 8 133869 632 90493938
Renal cortical necrosis 10.02 9.04 6 133871 297 90494273
Osteomyelitis 10.01 9.04 73 133804 27773 90466797
Cholestasis of pregnancy 10.00 9.04 12 133865 1565 90493005
Nasal mucosal disorder 9.97 9.04 13 133864 1844 90492726
Blood ethanol 9.89 9.04 3 133874 25 90494545
Blood pressure abnormal 9.84 9.04 56 133821 19589 90474981
Rotator cuff syndrome 9.77 9.04 48 133829 15871 90478699
Hordeolum 9.76 9.04 22 133855 4856 90489714
Motor dysfunction 9.75 9.04 55 133822 19175 90475395
Pharyngitis streptococcal 9.74 9.04 41 133836 12701 90481869
Blood pressure fluctuation 9.74 9.04 42 133835 52371 90442199
Spinal cord injury 9.73 9.04 10 133867 1099 90493471
Gastrointestinal infection 9.72 9.04 37 133840 10953 90483617
Application site alopecia 9.69 9.04 3 133874 27 90494543
Open fracture 9.69 9.04 7 133870 477 90494093
Accelerated idioventricular rhythm 9.66 9.04 4 133873 88 90494482
Fear-related avoidance of activities 9.66 9.04 5 133872 186 90494384
Ischaemia 9.63 9.04 23 133854 5272 90489298
Intervertebral disc protrusion 9.61 9.04 71 133806 27125 90467445
Incorrect product formulation administered 9.58 9.04 5 133872 189 90494381
Spinal cord ischaemia 9.58 9.04 4 133873 90 90494480
Skin test positive 9.54 9.04 9 133868 891 90493679
Cranial nerve palsies multiple 9.54 9.04 4 133873 91 90494479
Concussion 9.53 9.04 37 133840 11054 90483516
Sinusitis bacterial 9.51 9.04 13 133864 1930 90492640
Eclampsia 9.51 9.04 7 133870 491 90494079
Infusion site injury 9.50 9.04 4 133873 92 90494478
Horner's syndrome 9.50 9.04 3 133874 29 90494541
Detachment of retinal pigment epithelium 9.42 9.04 7 133870 498 90494072
Anorgasmia 9.40 9.04 8 133869 692 90493878
Inappropriate antidiuretic hormone secretion 9.34 9.04 9 133868 19496 90475074
General symptom 9.34 9.04 5 133872 14663 90479907
Blood methaemoglobin present 9.30 9.04 4 133873 97 90494473
Retinal cyst 9.30 9.04 4 133873 97 90494473
Dizziness postural 9.29 9.04 32 133845 9021 90485549
Carotid artery dissection 9.28 9.04 5 133872 202 90494368
Uterine atony 9.26 9.04 6 133871 342 90494228
Administration site nodule 9.23 9.04 3 133874 32 90494538
Dose calculation error 9.21 9.04 6 133871 345 90494225
Oral pain 9.20 9.04 81 133796 32602 90461968
Nervous system disorder 9.19 9.04 59 133818 21534 90473036
Orbital oedema 9.16 9.04 6 133871 348 90494222
Sympathectomy 9.15 9.04 3 133874 33 90494537
Coccygectomy 9.15 9.04 3 133874 33 90494537
Granulomatous liver disease 9.14 9.04 9 133868 940 90493630
Electrocardiogram ST segment depression 9.10 9.04 17 133860 3286 90491284
Panniculitis 9.10 9.04 5 133872 14453 90480117
Hypoalbuminaemia 9.10 9.04 47 133830 15850 90478720
Poor quality product administered 9.08 9.04 19 133858 3989 90490581
Blepharoplasty 9.07 9.04 3 133874 34 90494536
Bladder spasm 9.07 9.04 13 133864 2017 90492553
Repetitive strain injury 9.06 9.04 5 133872 212 90494358

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 678.18 10.57 221 71148 2079 42547887
Anaphylactic shock 478.95 10.57 361 71008 23156 42526810
Product adhesion issue 378.29 10.57 133 71236 1606 42548360
Anaphylactic reaction 272.88 10.57 347 71022 42396 42507570
Methaemoglobinaemia 225.43 10.57 133 71236 5641 42544325
Cardiac arrest 221.63 10.57 534 70835 108786 42441180
Anaesthetic complication 191.28 10.57 77 71292 1380 42548586
Inspiratory capacity decreased 178.63 10.57 91 71278 2876 42547090
Product quality issue 136.53 10.57 159 71210 17723 42532243
Generalised tonic-clonic seizure 127.16 10.57 187 71182 26192 42523774
Toxic anterior segment syndrome 120.31 10.57 55 71314 1361 42548605
Hypotension 107.73 10.57 769 70600 256862 42293104
Toxicity to various agents 106.49 10.57 702 70667 228434 42321532
Bradycardia 97.55 10.57 340 71029 85144 42464822
Ventricular tachycardia 96.85 10.57 178 71191 29982 42519984
Ventricular fibrillation 90.77 10.57 173 71196 29950 42520016
Infusion site pain 82.39 10.57 70 71299 5325 42544641
Sinusitis 79.06 10.57 215 71154 47077 42502889
Lagophthalmos 73.49 10.57 21 71348 120 42549846
Electrocardiogram ST segment elevation 72.70 10.57 68 71301 5871 42544095
Unresponsive to stimuli 70.71 10.57 160 71209 31243 42518723
Injury 67.02 10.57 128 71241 22188 42527778
Drug ineffective for unapproved indication 66.58 10.57 199 71170 45964 42504002
Bronchospasm 65.95 10.57 94 71275 12791 42537175
Overdose 65.19 10.57 348 71021 104916 42445050
Cauda equina syndrome 64.70 10.57 32 71337 948 42549018
Emotional distress 63.44 10.57 104 71265 15989 42533977
Spinal cord infarction 63.37 10.57 28 71341 638 42549328
Incorrect route of product administration 62.90 10.57 131 71238 24174 42525792
Fear 62.12 10.57 84 71285 10881 42539085
Infusion site erythema 59.45 10.57 49 71320 3573 42546393
Infusion site extravasation 58.13 10.57 58 71311 5423 42544543
Retinal artery occlusion 54.14 10.57 38 71331 2177 42547789
Infusion site swelling 52.92 10.57 44 71325 3248 42546718
Tachycardia 51.94 10.57 318 71051 100769 42449197
Anal inflammation 51.61 10.57 37 71332 2192 42547774
Adulterated product 50.54 10.57 25 71344 741 42549225
Anhedonia 48.66 10.57 62 71307 7578 42542388
Sinus tachycardia 48.47 10.57 107 71262 20546 42529420
Hyperthermia malignant 47.95 10.57 38 71331 2620 42547346
Seizure 47.42 10.57 355 71014 120206 42429760
SARS-CoV-2 test negative 47.02 10.57 32 71337 1743 42548223
Ear infection 46.81 10.57 80 71289 12724 42537242
Kounis syndrome 45.98 10.57 41 71328 3327 42546639
Renal injury 45.25 10.57 77 71292 12203 42537763
Diarrhoea 43.74 10.57 528 70841 460321 42089645
Interstitial lung disease 42.70 10.57 41 71328 78421 42471545
Loss of consciousness 42.18 10.57 282 71087 92072 42457894
Acute kidney injury 41.59 10.57 404 70965 366933 42183033
Apnoea 41.53 10.57 58 71311 7745 42542221
Status epilepticus 41.52 10.57 85 71284 15493 42534473
Drug ineffective 40.69 10.57 1359 70010 628838 41921128
Respiratory arrest 40.47 10.57 122 71247 28302 42521664
Hypoxia 39.35 10.57 225 71144 69561 42480405
Neurotoxicity 38.98 10.57 107 71262 23544 42526422
Cardiogenic shock 38.25 10.57 139 71230 35501 42514465
Chemical burn 37.37 10.57 16 71353 337 42549629
Insurance issue 37.24 10.57 40 71329 4076 42545890
Proctalgia 36.67 10.57 52 71317 7041 42542925
Trigemino-cardiac reflex 36.60 10.57 16 71353 355 42549611
Endophthalmitis 36.50 10.57 41 71328 4392 42545574
Hypoxic-ischaemic encephalopathy 35.98 10.57 44 71325 5158 42544808
Wrong product administered 35.73 10.57 48 71321 6178 42543788
Accident 35.60 10.57 49 71320 6454 42543512
Shock 35.08 10.57 118 71251 29003 42520963
Pain 34.97 10.57 590 70779 244258 42305708
Embolia cutis medicamentosa 34.06 10.57 15 71354 339 42549627
Mydriasis 33.65 10.57 56 71313 8714 42541252
Psoriasis 33.34 10.57 20 71349 48584 42501382
Infusion site pruritus 33.12 10.57 22 71347 1151 42548815
Circulatory collapse 32.29 10.57 100 71269 23536 42526430
Ventricular extrasystoles 32.13 10.57 70 71299 13320 42536646
Corneal oedema 32.01 10.57 24 71345 1524 42548442
Procedural complication 31.34 10.57 37 71332 4182 42545784
Electrocardiogram QRS complex prolonged 30.57 10.57 43 71326 5780 42544186
Haemodynamic instability 30.54 10.57 66 71303 12491 42537475
Removal of foreign body 30.43 10.57 7 71362 13 42549953
General physical health deterioration 30.36 10.57 140 71229 151106 42398860
Accidental overdose 29.98 10.57 110 71259 28220 42521746
Anaesthetic complication neurological 28.85 10.57 17 71352 719 42549247
Completed suicide 28.28 10.57 76 71293 96389 42453577
Disease progression 28.23 10.57 134 71235 143522 42406444
Unevaluable event 28.16 10.57 123 71246 34165 42515801
Stress 27.90 10.57 147 71222 44065 42505901
Anaphylactoid shock 26.89 10.57 14 71355 463 42549503
Type I hypersensitivity 26.89 10.57 25 71344 2141 42547825
Weight decreased 25.94 10.57 223 71146 207725 42342241
Mental status changes 25.87 10.57 139 71230 41976 42507990
Hyperaesthesia 25.56 10.57 40 71329 5912 42544054
Blood phosphorus increased 25.11 10.57 61 71308 12464 42537502
Oculocardiac reflex 25.06 10.57 9 71360 116 42549850
Erythema 24.79 10.57 285 71084 108508 42441458
Infusion site haemorrhage 24.64 10.57 19 71350 1258 42548708
Miosis 24.35 10.57 63 71306 13383 42536583
Postoperative delirium 23.89 10.57 14 71355 586 42549380
Tracheitis 23.49 10.57 17 71352 1022 42548944
Infusion site irritation 23.41 10.57 12 71357 384 42549582
Torsade de pointes 23.03 10.57 47 71322 8547 42541419
Suicide attempt 22.92 10.57 26 71343 46074 42503892
Laryngospasm 22.88 10.57 22 71347 1966 42548000
Accidental death 22.84 10.57 27 71342 3056 42546910
Post procedural complication 22.81 10.57 59 71310 12531 42537435
Vasoplegia syndrome 22.62 10.57 25 71344 2630 42547336
Infusion site bruising 22.50 10.57 16 71353 936 42549030
Spinal meningeal cyst 22.43 10.57 8 71361 101 42549865
Prostate cancer 22.39 10.57 25 71344 44618 42505348
Drug resistance 22.24 10.57 15 71354 34233 42515733
Rheumatoid arthritis 22.14 10.57 23 71346 42417 42507549
Administration related reaction 21.82 10.57 9 71360 172 42549794
Leukopenia 21.82 10.57 59 71310 74687 42475279
Amaurosis 21.77 10.57 15 71354 834 42549132
Foreign body 21.60 10.57 16 71353 997 42548969
Postictal state 21.51 10.57 16 71353 1004 42548962
Respiratory depression 21.45 10.57 75 71294 18793 42531173
Macular ischaemia 21.40 10.57 9 71360 181 42549785
Paraplegia 21.38 10.57 27 71342 3270 42546696
Neuralgia 21.05 10.57 92 71277 25555 42524411
Ophthalmoplegia 21.00 10.57 22 71347 2178 42547788
Injection related reaction 20.97 10.57 13 71356 603 42549363
Negative pressure pulmonary oedema 20.80 10.57 13 71356 612 42549354
Myocardial infarction 20.29 10.57 123 71246 123886 42426080
Death 20.00 10.57 619 70750 470566 42079400
Respiratory tract infection bacterial 19.87 10.57 20 71349 1889 42548077
Brain stem syndrome 19.85 10.57 13 71356 664 42549302
Delayed recovery from anaesthesia 19.57 10.57 16 71353 1153 42548813
Brain oedema 19.52 10.57 66 71303 16261 42533705
Tryptase increased 19.51 10.57 10 71359 320 42549646
Appendicolith 19.38 10.57 58 71311 13398 42536568
Quadriplegia 19.34 10.57 21 71348 2166 42547800
Intracranial hypotension 19.22 10.57 11 71358 440 42549526
Condition aggravated 19.21 10.57 314 71055 260440 42289526
Reperfusion arrhythmia 19.10 10.57 7 71362 96 42549870
Analgesic therapy 19.07 10.57 37 71332 6487 42543479
Anal sphincter atony 19.06 10.57 8 71361 160 42549806
Respiratory tract infection 19.06 10.57 91 71278 26231 42523735
Neutropenia 19.01 10.57 228 71141 199203 42350763
Inadequate analgesia 18.89 10.57 25 71344 3172 42546794
Myelosuppression 18.86 10.57 24 71345 40437 42509529
Weight increased 18.79 10.57 105 71264 107878 42442088
Administration site pain 18.71 10.57 11 71358 463 42549503
Hyperphosphataemia 18.68 10.57 56 71313 12948 42537018
Sinus bradycardia 18.61 10.57 61 71308 14792 42535174
Blood pressure fluctuation 18.56 10.57 11 71358 26897 42523069
Paraesthesia oral 18.53 10.57 32 71337 5131 42544835
Thrombocytopenia 18.34 10.57 217 71152 190062 42359904
Mean arterial pressure increased 18.26 10.57 6 71363 58 42549908
Cyanosis 18.18 10.57 61 71308 14970 42534996
Blood pressure decreased 18.18 10.57 163 71206 58169 42491797
Hypertonia 17.95 10.57 31 71338 4970 42544996
Infusion site discharge 17.92 10.57 10 71359 381 42549585
Tubulointerstitial nephritis 17.73 10.57 16 71353 31532 42518434
Pancreatitis acute 17.72 10.57 18 71351 33546 42516420
Hypoaesthesia oral 17.68 10.57 30 71339 4743 42545223
Respiratory tract infection viral 17.65 10.57 25 71344 3381 42546585
Blindness 17.52 10.57 68 71301 17910 42532056
Pulse absent 17.42 10.57 35 71334 6292 42543674
Respiratory acidosis 17.41 10.57 35 71334 6296 42543670
Myasthenia gravis 17.36 10.57 63 71306 16074 42533892
Drug therapy 17.22 10.57 35 71334 6345 42543621
Anticholinergic syndrome 17.19 10.57 17 71352 1572 42548394
Therapeutic product effect incomplete 17.16 10.57 61 71308 70878 42479088
Myoclonus 17.01 10.57 65 71304 17000 42532966
Haemorrhoids 16.94 10.57 65 71304 17032 42532934
Fatigue 16.87 10.57 579 70790 435062 42114904
Oxygen saturation decreased 16.82 10.57 174 71195 64513 42485453
Open globe injury 16.73 10.57 6 71363 77 42549889
Application site erythema 16.62 10.57 21 71348 2545 42547421
Aqueous fibrin 16.59 10.57 6 71363 79 42549887
Sleep disorder therapy 16.49 10.57 36 71333 6858 42543108
Decreased appetite 16.48 10.57 226 71143 192911 42357055
Loss of personal independence in daily activities 16.35 10.57 37 71332 49779 42500187
Seizure like phenomena 16.27 10.57 14 71355 1083 42548883
Application site alopecia 16.18 10.57 3 71366 0 42549966
Electrocardiogram QRS complex 16.18 10.57 3 71366 0 42549966
Neuromuscular blockade 16.15 10.57 9 71360 342 42549624
Administration site swelling 16.05 10.57 8 71361 241 42549725
Diabetes insipidus 16.01 10.57 25 71344 3688 42546278
Prostatic pain 15.96 10.57 9 71360 350 42549616
Procedural pain 15.95 10.57 32 71337 5747 42544219
Cardiotoxicity 15.72 10.57 37 71332 7408 42542558
Hypophosphataemia 15.60 10.57 73 71296 20872 42529094
Urticaria 15.56 10.57 191 71178 73845 42476121
Hallucination, auditory 15.55 10.57 3 71366 14861 42535105
Agranulocytosis 15.51 10.57 17 71352 30595 42519371
Sleep disorder due to a general medical condition 15.40 10.57 5 71364 17448 42532518
Procedural hypotension 15.28 10.57 13 71356 990 42548976
Ventricular arrhythmia 15.26 10.57 33 71336 6246 42543720
Electrocardiogram T wave amplitude increased 15.25 10.57 6 71363 101 42549865
Blindness transient 15.24 10.57 21 71348 2768 42547198
Thyrotoxic crisis 15.21 10.57 12 71357 822 42549144
Hepatotoxicity 15.08 10.57 12 71357 25155 42524811
Nystagmus 15.04 10.57 30 71339 5366 42544600
Croup infectious 15.02 10.57 10 71359 525 42549441
Haematochezia 14.98 10.57 49 71320 58387 42491579
Procedural haemorrhage 14.94 10.57 21 71348 2820 42547146
Nightmare 14.89 10.57 12 71357 25000 42524966
Arthritis 14.84 10.57 30 71339 42035 42507931
Otospondylomegaepiphyseal dysplasia 14.78 10.57 6 71363 110 42549856
Ventricular tachyarrhythmia 14.75 10.57 9 71360 406 42549560
Febrile neutropenia 14.67 10.57 411 70958 185292 42364674
Ventricular asystole 14.65 10.57 8 71361 292 42549674
Infusion site nodule 14.63 10.57 6 71363 113 42549853
Chondrolysis 14.48 10.57 6 71363 116 42549850
Body temperature increased 14.46 10.57 70 71299 20288 42529678
Frequent bowel movements 14.41 10.57 9 71360 21398 42528568
Asthenia 14.41 10.57 359 71010 280434 42269532
Asthma 14.14 10.57 55 71314 62259 42487707
Posterior capsule rupture 14.13 10.57 4 71365 22 42549944
Infusion site reaction 14.09 10.57 14 71355 1302 42548664
Appendicitis 14.02 10.57 70 71299 20543 42529423
Lymphocyte count decreased 13.96 10.57 87 71282 27722 42522244
Cardiac failure congestive 13.95 10.57 85 71284 85517 42464449
Pneumocystis jirovecii pneumonia 13.88 10.57 13 71356 25168 42524798
Paralysis 13.87 10.57 34 71335 6986 42542980
Anxiety 13.84 10.57 277 71092 118283 42431683
Drug interaction 13.80 10.57 341 71028 266658 42283308
Polyneuropathy 13.78 10.57 7 71362 18654 42531312
Sleep deficit 13.74 10.57 12 71357 947 42549019
Full blood count abnormal 13.64 10.57 18 71351 29858 42520108
Diabetic retinal oedema 13.63 10.57 7 71362 225 42549741
Drug hypersensitivity 13.60 10.57 238 71131 99151 42450815
Dyspnoea exertional 13.59 10.57 41 71328 50107 42499859
Catecholamine crisis 13.55 10.57 5 71364 70 42549896
Application site pain 13.43 10.57 18 71351 2311 42547655
Pulmonary fibrosis 13.31 10.57 15 71354 26666 42523300
Laryngeal oedema 13.30 10.57 24 71345 3984 42545982
Bladder cancer 13.19 10.57 6 71363 17041 42532925
Restlessness 13.15 10.57 89 71280 29160 42520806
Tonic convulsion 13.07 10.57 15 71354 1644 42548322
Hepatitis 12.92 10.57 16 71353 27284 42522682
Myalgia 12.89 10.57 101 71268 95979 42453987
Histamine level increased 12.88 10.57 5 71364 81 42549885
Post herpetic neuralgia 12.87 10.57 13 71356 1233 42548733
Pulseless electrical activity 12.75 10.57 37 71332 8400 42541566
Colitis ulcerative 12.75 10.57 15 71354 26160 42523806
Laryngeal stenosis 12.64 10.57 6 71363 162 42549804
Foetal exposure during pregnancy 12.59 10.57 39 71330 47272 42502694
Vitreous disorder 12.57 10.57 6 71363 164 42549802
Melaena 12.54 10.57 29 71340 38717 42511249
Cardiac murmur 12.50 10.57 3 71366 12772 42537194
Coronary artery disease 12.46 10.57 47 71322 53673 42496293
Administration site reaction 12.45 10.57 5 71364 89 42549877
Retinal degeneration 12.45 10.57 10 71359 703 42549263
Vitreous floaters 12.37 10.57 24 71345 4206 42545760
Treatment noncompliance 12.35 10.57 28 71341 37644 42512322
Intentional self-injury 12.32 10.57 5 71364 15197 42534769
Cytomegalovirus infection 12.31 10.57 22 71347 32284 42517682
Eczema 12.29 10.57 24 71345 34062 42515904
Painful ejaculation 12.28 10.57 6 71363 173 42549793
Enterobacter pneumonia 12.28 10.57 9 71360 552 42549414
Induration 12.24 10.57 12 71357 1098 42548868
Cardiac procedure complication 12.19 10.57 6 71363 176 42549790
Blood uric acid increased 12.18 10.57 55 71314 15492 42534474
Application site irritation 12.12 10.57 10 71359 730 42549236
Myopathy toxic 12.11 10.57 10 71359 731 42549235
Blood pH decreased 12.11 10.57 17 71352 2281 42547685
Penile vascular disorder 12.04 10.57 3 71366 9 42549957
Product contamination microbial 12.00 10.57 10 71359 740 42549226
Bronchoscopy abnormal 11.96 10.57 4 71365 41 42549925
Atrioventricular block complete 11.92 10.57 44 71325 11320 42538646
Diabetic ketoacidosis 11.80 10.57 12 71357 22355 42527611
Injection site joint infection 11.79 10.57 4 71365 43 42549923
Blood methaemoglobin present 11.79 10.57 4 71365 43 42549923
Arthralgia 11.75 10.57 258 71111 204980 42344986
Iron deficiency 11.74 10.57 43 71326 11018 42538948
Airway complication of anaesthesia 11.74 10.57 6 71363 191 42549775
Phaeochromocytoma crisis 11.73 10.57 5 71364 104 42549862
Administration site irritation 11.58 10.57 3 71366 11 42549955
Impaired work ability 11.52 10.57 3 71366 12088 42537878
Disease recurrence 11.50 10.57 20 71349 29658 42520308
Oral lichen planus 11.48 10.57 6 71363 200 42549766
Psoriatic arthropathy 11.44 10.57 15 71354 24952 42525014
Chills 11.38 10.57 221 71148 93845 42456121
Anterior chamber cell 11.37 10.57 8 71361 460 42549506
Incorrect product formulation administered 11.32 10.57 4 71365 49 42549917
Underdose 11.23 10.57 7 71362 16659 42533307
Pupillary reflex impaired 11.22 10.57 14 71355 1675 42548291
Respiratory paralysis 11.19 10.57 5 71364 117 42549849
Myokymia 11.19 10.57 5 71364 117 42549849
Complex regional pain syndrome 11.16 10.57 9 71360 636 42549330
Oesophageal injury 11.14 10.57 6 71363 213 42549753
Abdominal discomfort 11.10 10.57 77 71292 75178 42474788
Off label use 11.05 10.57 920 70449 637415 41912551
Hypotonia 11.00 10.57 38 71331 9461 42540505
Stress cardiomyopathy 10.98 10.57 18 71351 2767 42547199
Retinal vasculitis 10.95 10.57 9 71360 654 42549312
Burkholderia test positive 10.93 10.57 11 71358 1039 42548927
Brugada syndrome 10.90 10.57 11 71358 1042 42548924
Full blood count decreased 10.88 10.57 11 71358 20549 42529417
Product distribution issue 10.88 10.57 15 71354 1979 42547987
Encephalomalacia 10.83 10.57 11 71358 1050 42548916
Neuroleptic malignant syndrome 10.79 10.57 12 71357 21460 42528506
Autonomic nervous system imbalance 10.77 10.57 19 71350 3097 42546869
Upper respiratory tract infection 10.75 10.57 113 71256 42060 42507906
Progressive multifocal leukoencephalopathy 10.73 10.57 3 71366 11533 42538433
Skin reaction 10.69 10.57 31 71338 7036 42542930
Infusion site discolouration 10.65 10.57 6 71363 233 42549733
Drug-induced liver injury 10.58 10.57 31 71338 38242 42511724
Bacteroides infection 10.58 10.57 17 71352 2570 42547396

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Local anaesthetic systemic toxicity 1729.37 9.36 542 166107 4995 110417655
Anaphylactic shock 917.82 9.36 700 165949 50846 110371804
Product adhesion issue 697.68 9.36 235 166414 2771 110419879
Anaphylactic reaction 666.16 9.36 841 165808 113459 110309191
Cardiac arrest 530.90 9.36 1014 165635 195739 110226911
Anaesthetic complication 403.70 9.36 165 166484 3441 110419209
Toxic anterior segment syndrome 379.71 9.36 156 166493 3298 110419352
Methaemoglobinaemia 351.10 9.36 201 166448 8967 110413683
Hypotension 334.67 9.36 1618 165031 522231 109900419
Maternal exposure during delivery 315.38 9.36 138 166511 3427 110419223
Synovitis 312.83 9.36 27 166622 274065 110148585
Hand deformity 281.19 9.36 11 166638 218495 110204155
Generalised tonic-clonic seizure 262.37 9.36 366 166283 54314 110368336
Toxicity to various agents 253.77 9.36 1408 165241 479147 109943503
Pemphigus 250.77 9.36 19 166630 214551 110208099
Hepatic enzyme increased 249.53 9.36 86 166563 320806 110101844
Systemic lupus erythematosus 248.75 9.36 42 166607 254296 110168354
Helicobacter infection 245.36 9.36 6 166643 181871 110240779
Pericarditis 238.38 9.36 26 166623 219088 110203562
Glossodynia 232.47 9.36 30 166619 221974 110200676
Anti-cyclic citrullinated peptide antibody positive 231.33 9.36 10 166639 181974 110240676
Duodenal ulcer perforation 215.65 9.36 13 166636 177687 110244963
Joint swelling 214.01 9.36 211 166438 442634 109980016
Bradycardia 213.14 9.36 615 166034 154902 110267748
Contraindicated product administered 210.17 9.36 57 166592 248210 110174440
Lagophthalmos 202.70 9.36 62 166587 522 110422128
Kounis syndrome 195.57 9.36 118 166531 5807 110416843
Arthropathy 189.94 9.36 98 166551 287424 110135226
General physical health deterioration 181.94 9.36 224 166425 425071 109997579
Paraesthesia oral 180.69 9.36 238 166411 33433 110389217
Folliculitis 177.10 9.36 22 166627 167631 110255019
Seizure 172.95 9.36 726 165923 220459 110202191
Ventricular tachycardia 172.27 9.36 287 166362 49722 110372928
Stress cardiomyopathy 168.63 9.36 160 166489 15646 110407004
Unresponsive to stimuli 162.33 9.36 321 166328 63469 110359181
Rheumatoid factor positive 155.66 9.36 11 166638 131629 110291021
Psoriatic arthropathy 154.16 9.36 52 166597 196709 110225941
Inspiratory capacity decreased 153.42 9.36 76 166573 2519 110420131
Ventricular fibrillation 153.01 9.36 245 166404 41068 110381582
Type 2 diabetes mellitus 151.28 9.36 40 166609 177192 110245458
Alopecia 150.89 9.36 197 166452 364556 110058094
Rheumatic fever 148.62 9.36 9 166640 122570 110300080
Bronchospasm 145.93 9.36 203 166446 30036 110392614
Wound 144.57 9.36 87 166562 234350 110188300
Muscle injury 142.72 9.36 21 166628 140786 110281864
Chronic sinusitis 140.34 9.36 181 166468 24903 110397747
Macular degeneration 139.96 9.36 168 166481 21491 110401159
Anaesthetic complication neurological 139.07 9.36 54 166595 979 110421671
Procedural pain 137.35 9.36 215 166434 35350 110387300
Abdominal discomfort 136.59 9.36 240 166409 393618 110029032
C-reactive protein abnormal 132.25 9.36 19 166630 129676 110292974
Drug intolerance 127.58 9.36 263 166386 406249 110016401
Rheumatoid arthritis 126.81 9.36 159 166490 299454 110123196
Impaired healing 124.12 9.36 71 166578 196646 110226004
Drug ineffective for unapproved indication 119.58 9.36 384 166265 102454 110320196
Cauda equina syndrome 119.12 9.36 60 166589 2062 110420588
Apnoea 117.65 9.36 123 166526 13516 110409134
Irritable bowel syndrome 117.62 9.36 50 166599 164165 110258485
Sedation complication 116.97 9.36 147 166502 19708 110402942
Facet joint syndrome 114.74 9.36 8 166641 96820 110325830
Completed suicide 114.11 9.36 118 166531 242263 110180387
Vaginal flatulence 112.87 9.36 114 166535 12030 110410620
Radiculopathy 108.92 9.36 140 166509 19196 110403454
Sleep disorder due to general medical condition, insomnia type 108.83 9.36 15 166634 105628 110317022
Emotional distress 108.50 9.36 221 166428 44626 110378024
Female genital tract fistula 108.16 9.36 129 166520 16390 110406260
Product quality issue 108.08 9.36 308 166341 76991 110345659
Fear 107.90 9.36 153 166496 23040 110399610
Erythema 106.97 9.36 779 165870 290668 110131982
Procedural hypotension 104.25 9.36 58 166591 2447 110420203
Ill-defined disorder 104.23 9.36 53 166596 156800 110265850
Therapeutic product effect decreased 104.05 9.36 129 166520 244187 110178463
Liver injury 102.71 9.36 49 166600 150364 110272286
Tachycardia 102.48 9.36 638 166011 226007 110196643
Swollen joint count increased 101.84 9.36 6 166643 83655 110338995
Incorrect route of product administration 101.25 9.36 267 166382 63794 110358856
Lip dry 101.25 9.36 15 166634 100068 110322582
Infusion site pain 101.08 9.36 128 166521 17291 110405359
Embolia cutis medicamentosa 100.80 9.36 42 166607 921 110421729
Loss of consciousness 100.56 9.36 571 166078 195735 110226915
Pulseless electrical activity 100.21 9.36 125 166524 16632 110406018
Proctitis 99.20 9.36 125 166524 16802 110405848
Sinus tachycardia 99.16 9.36 212 166437 44281 110378369
Corneal oedema 99.11 9.36 61 166588 3112 110419538
Overdose 97.02 9.36 644 166005 233150 110189500
Depressed level of consciousness 96.80 9.36 380 166269 111898 110310752
Peripheral venous disease 96.70 9.36 8 166641 84109 110338541
Pulse absent 95.91 9.36 101 166548 11191 110411459
Bursitis 95.55 9.36 38 166611 129880 110292770
Status epilepticus 94.11 9.36 170 166479 31401 110391249
Infusion site swelling 92.31 9.36 93 166556 9784 110412866
Insurance issue 92.07 9.36 96 166553 10516 110412134
Lower respiratory tract infection 90.87 9.36 141 166508 242965 110179685
Musculoskeletal stiffness 89.47 9.36 179 166470 279643 110143007
Infusion site erythema 89.40 9.36 100 166549 11859 110410791
Arthralgia 89.23 9.36 749 165900 778883 109643767
Vaginal discharge 89.08 9.36 122 166527 17786 110404864
Retinal artery occlusion 87.46 9.36 63 166586 4186 110418464
Type I hypersensitivity 86.52 9.36 74 166575 6319 110416331
Creatinine renal clearance decreased 85.80 9.36 133 166516 21682 110400968
Inflammation 85.50 9.36 99 166550 193139 110229511
Fibromyalgia 84.11 9.36 80 166569 170829 110251821
Body tinea 82.67 9.36 47 166602 2068 110420582
Mental status changes 78.49 9.36 273 166376 75849 110346801
Hyperthermia malignant 78.39 9.36 57 166592 3843 110418807
Endophthalmitis 78.19 9.36 78 166571 8109 110414541
Spinal cord infarction 76.54 9.36 36 166613 1062 110421588
Sulphaemoglobinaemia 76.21 9.36 30 166619 565 110422085
Renal injury 74.87 9.36 115 166534 18598 110404052
Hypercholesterolaemia 74.71 9.36 22 166627 90815 110331835
Constipation 73.67 9.36 844 165805 356942 110065708
Anhedonia 73.58 9.36 103 166546 15325 110407325
Respiratory arrest 73.57 9.36 224 166425 58075 110364575
Blood calcium decreased 73.30 9.36 165 166484 35680 110386970
Neurotoxicity 70.90 9.36 180 166469 42027 110380623
Electrocardiogram ST segment elevation 70.90 9.36 78 166571 9082 110413568
Circulatory collapse 69.79 9.36 181 166468 42812 110379838
Phrenic nerve paralysis 69.62 9.36 28 166621 559 110422091
Hypoxia 69.14 9.36 381 166268 129134 110293516
Post procedural complication 68.83 9.36 135 166514 26523 110396127
Extradural abscess 68.40 9.36 41 166608 1993 110420657
Infusion site haemorrhage 67.96 9.36 56 166593 4542 110418108
Abdominal pain upper 67.80 9.36 283 166366 348828 110073822
Deep vein thrombosis postoperative 67.16 9.36 6 166643 59285 110363365
Paraplegia 66.59 9.36 63 166586 6137 110416513
Joint range of motion decreased 66.05 9.36 52 166597 121780 110300870
Condition aggravated 65.49 9.36 750 165899 734086 109688564
Dermatitis contact 64.84 9.36 92 166557 13861 110408789
Gait inability 63.47 9.36 67 166582 136309 110286341
Infusion site bruising 63.15 9.36 49 166600 3645 110419005
Grip strength decreased 63.10 9.36 21 166628 80153 110342497
Cardiogenic shock 62.95 9.36 210 166439 57128 110365522
Oral candidiasis 61.25 9.36 177 166472 44583 110378067
Obesity 60.67 9.36 49 166600 113302 110309348
Peripheral swelling 60.40 9.36 359 166290 403675 110018975
Tracheal deviation 60.20 9.36 21 166628 277 110422373
Swelling 59.56 9.36 299 166350 350742 110071908
C-reactive protein increased 59.39 9.36 152 166497 217767 110204883
Unevaluable event 58.98 9.36 210 166439 59017 110363633
Gastrointestinal disorder 57.65 9.36 180 166469 241772 110180878
Pulmonary fibrosis 57.30 9.36 42 166607 102000 110320650
Paralysis 57.05 9.36 92 166557 15508 110407142
Shock 56.83 9.36 194 166455 53394 110369256
Liver disorder 56.55 9.36 79 166570 142164 110280486
Psoriasis 56.41 9.36 77 166572 139916 110282734
Systemic toxicity 56.21 9.36 21 166628 341 110422309
Ophthalmoplegia 56.19 9.36 45 166604 3505 110419145
Treatment failure 56.16 9.36 221 166428 277013 110145637
Infusion site pruritus 55.92 9.36 52 166597 4956 110417694
Blood cholesterol increased 55.85 9.36 122 166527 184663 110237987
Nystagmus 54.78 9.36 77 166572 11500 110411150
Infusion site extravasation 54.49 9.36 77 166572 11557 110411093
Accidental overdose 54.40 9.36 187 166462 51647 110371003
Trigemino-cardiac reflex 54.26 9.36 22 166627 449 110422201
Diarrhoea 53.94 9.36 1307 165342 1138198 109284452
Adjustment disorder with depressed mood 53.86 9.36 3 166646 43880 110378770
Wound infection 53.78 9.36 40 166609 96425 110326225
Blepharospasm 53.72 9.36 9 166640 54842 110367808
Nail disorder 53.53 9.36 11 166638 57924 110364726
Weight increased 53.08 9.36 392 166257 419252 110003398
Anaphylactoid shock 52.78 9.36 27 166622 959 110421691
Lower limb fracture 52.27 9.36 24 166625 75324 110347326
Cyanosis 52.22 9.36 129 166520 29612 110393038
Blood pressure decreased 51.99 9.36 324 166325 114767 110307883
Intentional product use issue 51.90 9.36 195 166454 247711 110174939
Removal of foreign body 51.89 9.36 12 166637 27 110422623
Anal inflammation 51.35 9.36 37 166612 2459 110420191
Hypoaesthesia oral 51.25 9.36 92 166557 16910 110405740
Creatinine renal clearance increased 51.19 9.36 43 166606 3582 110419068
Staphylococcal infection 51.07 9.36 225 166424 69719 110352931
Mydriasis 51.02 9.36 107 166542 22050 110400600
Wrong product administered 50.53 9.36 72 166577 10888 110411762
Respiratory depression 50.18 9.36 133 166516 31868 110390782
Proctalgia 49.76 9.36 79 166570 13143 110409507
Arthritis 49.53 9.36 112 166537 167474 110255176
Blister 49.47 9.36 176 166473 227200 110195450
Procedural complication 49.14 9.36 62 166587 8343 110414307
Night sweats 48.82 9.36 79 166570 133904 110288746
Meningitis chemical 48.60 9.36 19 166630 351 110422299
Onychomadesis 48.19 9.36 6 166643 45657 110376993
Infection susceptibility increased 47.83 9.36 45 166604 4353 110418297
Osteoarthritis 47.77 9.36 130 166519 182493 110240157
Anterior chamber cell 47.37 9.36 27 166622 1194 110421456
Red blood cell sedimentation rate increased 46.94 9.36 30 166619 78272 110344378
Sleep disorder 46.46 9.36 149 166500 198495 110224155
Haemodynamic instability 46.40 9.36 105 166544 22783 110399867
Urinary tract infection 46.08 9.36 719 165930 325563 110097087
Hypopyon 45.78 9.36 28 166621 1412 110421238
Suicide attempt 45.69 9.36 53 166596 103341 110319309
Vascular malformation 45.65 9.36 23 166626 791 110421859
Inhibitory drug interaction 45.17 9.36 46 166603 4901 110417749
Lung disorder 45.00 9.36 131 166518 179916 110242734
Haemorrhoids 44.95 9.36 137 166512 35535 110387115
Illness 44.70 9.36 243 166406 81928 110340722
Knee arthroplasty 44.57 9.36 21 166628 64927 110357723
Chemical burn 44.50 9.36 22 166627 726 110421924
SARS-CoV-2 test negative 44.49 9.36 32 166617 2121 110420529
Underdose 44.46 9.36 20 166629 63534 110359116
Wheezing 44.07 9.36 216 166433 255014 110167636
Adverse event 43.68 9.36 60 166589 108749 110313901
Paranasal cyst 43.37 9.36 23 166626 881 110421769
Adulterated product 43.36 9.36 25 166624 1130 110421520
Stress 42.94 9.36 289 166360 105059 110317591
Infusion related reaction 42.67 9.36 368 166281 380794 110041856
Infusion site discharge 42.32 9.36 30 166619 1943 110420707
Ventricular extrasystoles 41.67 9.36 100 166549 22541 110400109
Lupus-like syndrome 41.52 9.36 6 166643 40786 110381864
Arthritis bacterial 41.20 9.36 65 166584 10755 110411895
Myelosuppression 41.00 9.36 49 166600 94291 110328359
Vitritis 40.66 9.36 33 166616 2620 110420030
Musculoskeletal pain 40.26 9.36 141 166508 182882 110239768
Electrocardiogram QRS complex prolonged 39.94 9.36 71 166578 12950 110409700
Drug-induced liver injury 39.92 9.36 75 166574 119992 110302658
Stomatitis 39.89 9.36 241 166408 270001 110152649
Acute kidney injury 39.71 9.36 696 165953 634734 109787916
Extradural haematoma 39.60 9.36 36 166613 3333 110419317
Incorrect drug administration rate 39.37 9.36 45 166604 5463 110417187
Aqueous fibrin 39.11 9.36 14 166635 200 110422450
Retinal vasculitis 39.05 9.36 29 166620 2020 110420630
Infusion site mass 38.75 9.36 27 166622 1701 110420949
Sedation 38.53 9.36 207 166442 69476 110353174
Hypersensitivity 38.44 9.36 406 166243 403592 110019058
Hepatotoxicity 38.40 9.36 24 166625 63376 110359274
Sopor 38.08 9.36 5 166644 36541 110386109
Hepatitis 37.84 9.36 48 166601 90006 110332644
Purtscher retinopathy 37.84 9.36 14 166635 221 110422429
Hypoxic-ischaemic encephalopathy 37.71 9.36 56 166593 8791 110413859
Brain stem syndrome 37.45 9.36 24 166625 1315 110421335
Visual acuity reduced 37.25 9.36 120 166529 32053 110390597
Rash 36.50 9.36 950 165699 820014 109602636
Mobility decreased 36.49 9.36 209 166440 237213 110185437
Seasonal allergy 36.18 9.36 87 166562 19635 110403015
Loss of personal independence in daily activities 36.15 9.36 111 166538 149909 110272741
Hyperaesthesia 36.12 9.36 73 166576 14654 110407996
Foot deformity 35.94 9.36 14 166635 48466 110374184
Fear of eating 35.85 9.36 17 166632 511 110422139
Product use issue 35.74 9.36 299 166350 311396 110111254
Prescribed overdose 35.45 9.36 48 166601 87533 110335117
Hip arthroplasty 35.39 9.36 20 166629 55793 110366857
Myopathy toxic 35.21 9.36 23 166626 1302 110421348
Quadriplegia 35.20 9.36 37 166612 4090 110418560
Miosis 35.11 9.36 92 166557 21891 110400759
Prescribed underdose 35.09 9.36 28 166621 65146 110357504
Cellulitis 34.87 9.36 316 166333 125700 110296950
Nasopharyngitis 34.86 9.36 403 166246 393958 110028692
Drug resistance 34.62 9.36 21 166628 56353 110366297
Coeliac disease 34.53 9.36 11 166638 43176 110379474
Tryptase increased 34.31 9.36 20 166629 923 110421727
Otitis media 34.30 9.36 49 166600 7427 110415223
Sinobronchitis 34.20 9.36 16 166633 466 110422184
Respiratory tract infection 33.84 9.36 204 166445 71413 110351237
Decreased appetite 33.75 9.36 509 166140 475337 109947313
Pneumocephalus 33.71 9.36 16 166633 482 110422168
Asthenia 33.40 9.36 787 165862 688212 109734438
Peripheral nerve injury 33.16 9.36 21 166628 1127 110421523
Renal function test abnormal 33.04 9.36 53 166596 8893 110413757
Spinal epidural haemorrhage 32.90 9.36 14 166635 324 110422326
Stridor 32.83 9.36 46 166603 6849 110415801
Delayed recovery from anaesthesia 32.78 9.36 27 166622 2188 110420462
Acute motor-sensory axonal neuropathy 32.53 9.36 16 166633 522 110422128
Postoperative delirium 32.22 9.36 19 166630 896 110421754
Laryngeal oedema 32.06 9.36 55 166594 9752 110412898
Glucose tolerance impaired 31.94 9.36 55 166594 9782 110412868
Product contamination microbial 31.57 9.36 20 166629 1074 110421576
Multiple allergies 31.54 9.36 62 166587 12201 110410449
Hyperlipidaemia 31.42 9.36 122 166527 35726 110386924
Discomfort 31.40 9.36 192 166457 214515 110208135
Back pain 31.02 9.36 755 165894 370241 110052409
Nerve root injury 30.87 9.36 9 166640 63 110422587
Premature delivery 30.83 9.36 109 166540 30523 110392127
Hepatic cirrhosis 30.60 9.36 34 166615 67592 110355058
Infection 30.52 9.36 374 166275 361826 110060824
Onychomycosis 30.48 9.36 10 166639 38521 110384129
Neuromuscular blockade 30.34 9.36 17 166632 727 110421923
Neuralgia 30.27 9.36 149 166500 48329 110374321
Lymphocyte count decreased 30.27 9.36 168 166481 57075 110365575
Anal sphincter atony 30.20 9.36 15 166634 500 110422150
Poor quality sleep 30.08 9.36 102 166547 27975 110394675
Spinal anaesthesia 29.91 9.36 10 166639 115 110422535
Autoimmune disorder 29.54 9.36 33 166616 65450 110357200
Analgesic therapy 29.47 9.36 45 166604 7239 110415411
Administration site erythema 29.39 9.36 14 166635 425 110422225
Diplopia 29.25 9.36 133 166516 41761 110380889
Febrile neutropenia 29.05 9.36 653 165996 316114 110106536
Agitation 29.03 9.36 279 166370 112772 110309878
Vocal cord dysfunction 29.00 9.36 18 166631 932 110421718
Mastoiditis 28.94 9.36 27 166622 2584 110420066
Vasoplegia syndrome 28.49 9.36 38 166611 5401 110417249
Appendicolith 28.46 9.36 65 166584 14190 110408460
Application site rash 28.44 9.36 26 166623 2424 110420226
Cardiotoxicity 28.35 9.36 72 166577 16809 110405841
Platelet aggregation inhibition 28.35 9.36 11 166638 199 110422451
Blood pressure fluctuation 28.32 9.36 43 166606 74781 110347869
Bundle branch block left 28.24 9.36 61 166588 12827 110409823
Interstitial lung disease 28.24 9.36 111 166538 139223 110283427
Diplegia 28.04 9.36 25 166624 2256 110420394
Eyelid ptosis 27.98 9.36 62 166587 13265 110409385
Confusional state 27.78 9.36 518 166131 468162 109954488
Blood phosphorus increased 27.77 9.36 70 166579 16270 110406380
Accident 27.71 9.36 55 166594 10897 110411753
Pain 27.68 9.36 1729 164920 953226 109469424
Hyperphosphataemia 27.65 9.36 70 166579 16311 110406339
Spinal epidural haematoma 27.59 9.36 22 166627 1703 110420947
Application site erythema 27.57 9.36 38 166611 5572 110417078
Upper respiratory tract infection 27.52 9.36 311 166338 131017 110291633
Fatigue 27.45 9.36 1526 165123 1214432 109208218
Inadequate analgesia 27.41 9.36 36 166613 5041 110417609
Chills 27.27 9.36 421 166228 190159 110232491
Epilepsy 27.21 9.36 70 166579 100139 110322511
Injection related reaction 27.12 9.36 21 166628 1557 110421093
Airway peak pressure increased 27.02 9.36 15 166634 630 110422020
Amaurosis 26.99 9.36 21 166628 1568 110421082
Cardio-respiratory arrest 26.90 9.36 280 166369 115556 110307094
Drug therapy 26.66 9.36 43 166606 7248 110415402
Product administration error 26.62 9.36 119 166530 37098 110385552
Depression 26.61 9.36 328 166321 317007 110105643
Tenderness 26.47 9.36 101 166548 29336 110393314
Taste disorder 26.30 9.36 36 166613 65351 110357299
Pallor 26.14 9.36 160 166489 56307 110366343
Sleep disorder therapy 25.89 9.36 43 166606 7428 110415222
Intentional self-injury 25.84 9.36 12 166637 37417 110385233
Neutropenia 25.77 9.36 403 166246 374217 110048433
C-reactive protein 25.58 9.36 7 166642 30324 110392326
Oculocardiac reflex 25.58 9.36 9 166640 122 110422528
Sinus bradycardia 25.57 9.36 100 166549 29383 110393267
Myoclonus 25.50 9.36 108 166541 32890 110389760
Trigeminal palsy 25.49 9.36 8 166641 74 110422576
Dysarthria 25.38 9.36 215 166434 83906 110338744
Hypophosphataemia 25.18 9.36 108 166541 33074 110389576
Spinal meningeal cyst 24.99 9.36 9 166640 131 110422519
Respiratory tract infection bacterial 24.90 9.36 24 166625 2392 110420258
Sensory loss 24.81 9.36 80 166569 21377 110401273
Soft tissue atrophy 24.80 9.36 7 166642 43 110422607
Back injury 24.73 9.36 21 166628 47378 110375272
Myasthenia gravis 24.69 9.36 80 166569 21431 110401219
Upper airway obstruction 24.67 9.36 21 166628 1781 110420869
Corneal epithelium defect 24.65 9.36 16 166633 896 110421754
Sinusitis 24.56 9.36 603 166046 296085 110126565
Memory impairment 24.38 9.36 185 166464 196759 110225891
Red blood cell sedimentation rate abnormal 24.05 9.36 4 166645 24505 110398145
Foreign body 24.04 9.36 26 166623 2969 110419681
Urticaria thermal 24.04 9.36 13 166636 518 110422132
Cognitive disorder 23.98 9.36 219 166430 87292 110335358
Product label confusion 23.88 9.36 3 166646 22674 110399976
Multiple drug therapy 23.69 9.36 43 166606 7971 110414679
Macular ischaemia 23.52 9.36 10 166639 231 110422419
Laryngospasm 23.51 9.36 32 166617 4636 110418014
Brain oedema 23.43 9.36 101 166548 30997 110391653
Quadriparesis 23.31 9.36 32 166617 4675 110417975
Anaphylactoid reaction 23.27 9.36 39 166610 6787 110415863
Accidental death 23.23 9.36 33 166616 4976 110417674
Pulmonary oedema 23.23 9.36 243 166406 100416 110322234
Spinal cord compression 22.93 9.36 41 166608 7511 110415139
Allergic sinusitis 22.86 9.36 20 166629 1761 110420889
Thrombocytopenia 22.77 9.36 379 166270 348506 110074144
Tubulointerstitial nephritis 22.74 9.36 29 166620 54255 110368395
Infusion site urticaria 22.70 9.36 17 166632 1199 110421451
Procedural haemorrhage 22.63 9.36 34 166615 5393 110417257
Sciatica 22.52 9.36 68 166581 92331 110330319
Disease progression 22.48 9.36 247 166402 243787 110178863
Arthritis infective 22.44 9.36 49 166600 10380 110412270
Neuromuscular block prolonged 22.32 9.36 17 166632 1230 110421420
Monoplegia 22.27 9.36 32 166617 4877 110417773
Respiratory acidosis 22.22 9.36 58 166591 13768 110408882
Product distribution issue 22.21 9.36 30 166619 4316 110418334
Drug tolerance decreased 22.05 9.36 7 166642 27533 110395117
Asthma 22.01 9.36 256 166393 250035 110172615
Aspiration joint abnormal 22.00 9.36 4 166645 0 110422650
Bursitis infective 21.86 9.36 18 166631 1458 110421192
Infusion site rash 21.78 9.36 22 166627 2321 110420329
Nerve block 21.71 9.36 14 166635 775 110421875
Foreign body in respiratory tract 21.52 9.36 11 166638 390 110422260
Pancreatitis acute 21.52 9.36 36 166613 60238 110362412
Tracheitis 21.43 9.36 19 166630 1702 110420948
Lactic acidosis 21.42 9.36 70 166579 92741 110329909
Colitis 21.29 9.36 242 166407 102081 110320569
Epidural haemorrhage 21.22 9.36 11 166638 402 110422248
Infusion site irritation 20.99 9.36 16 166633 1159 110421491
Airway complication of anaesthesia 20.98 9.36 13 166636 671 110421979
Drug ineffective 20.85 9.36 2605 164044 1517935 108904715
Leukopenia 20.75 9.36 135 166514 148656 110273994
Negative pressure pulmonary oedema 20.72 9.36 13 166636 686 110421964
Punctate keratitis 20.65 9.36 16 166633 1188 110421462
Joint stiffness 20.64 9.36 44 166605 67199 110355451
Medical device site cellulitis 20.62 9.36 9 166640 222 110422428
Multiple organ dysfunction syndrome 20.52 9.36 332 166317 151378 110271272
Appendicitis 20.35 9.36 91 166558 28373 110394277
Allodynia 20.18 9.36 20 166629 2063 110420587
Atonic urinary bladder 19.97 9.36 8 166641 158 110422492
Exostosis 19.83 9.36 24 166625 45932 110376718
Atrioventricular block complete 19.82 9.36 71 166578 20011 110402639
Orthostatic hypotension 19.81 9.36 169 166480 66080 110356570
Spinal cord oedema 19.71 9.36 11 166638 467 110422183
Epidural analgesia 19.65 9.36 8 166641 165 110422485
Application site pain 19.52 9.36 32 166617 5467 110417183
Pupillary reflex impaired 19.44 9.36 27 166622 3988 110418662
Anaesthetic complication pulmonary 19.43 9.36 8 166641 170 110422480
Mean arterial pressure decreased 19.43 9.36 11 166638 480 110422170
Procedure aborted 19.30 9.36 8 166641 173 110422477
Injection site atrophy 19.27 9.36 11 166638 488 110422162
Intracranial hypotension 19.25 9.36 12 166637 626 110422024
Bronchitis 19.17 9.36 338 166311 156694 110265956
Diabetes insipidus 19.10 9.36 35 166614 6535 110416115
Injection site necrosis 19.07 9.36 18 166631 1748 110420902
Blindness transient 18.94 9.36 33 166616 5923 110416727
Drug reaction with eosinophilia and systemic symptoms 18.89 9.36 62 166587 82033 110340617
Central pain syndrome 18.83 9.36 13 166636 807 110421843
Glossoptosis 18.81 9.36 9 166640 276 110422374
Mean arterial pressure increased 18.72 9.36 7 166642 114 110422536
Restlessness 18.70 9.36 147 166502 56112 110366538
Foetal heart rate abnormal 18.63 9.36 12 166637 663 110421987
Ventricular tachyarrhythmia 18.59 9.36 11 166638 522 110422128
Dry mouth 18.56 9.36 202 166447 199746 110222904
Parophthalmia 18.53 9.36 11 166638 525 110422125
COVID-19 18.49 9.36 492 166157 244568 110178082
Infusion site discomfort 18.47 9.36 18 166631 1819 110420831
Corneal abrasion 18.44 9.36 16 166633 1393 110421257
Prostatic pain 18.40 9.36 9 166640 290 110422360
Anxiety 18.38 9.36 664 165985 344414 110078236
Respiratory distress 18.18 9.36 171 166478 68703 110353947
Thyroid atrophy 18.18 9.36 9 166640 298 110422352
Medical device site abscess 18.16 9.36 8 166641 202 110422448
Prostate cancer 18.07 9.36 18 166631 37623 110385027
Skin test positive 18.05 9.36 16 166633 1433 110421217
Balance disorder 18.04 9.36 261 166388 116299 110306351
Spinal cord injury 18.04 9.36 17 166632 1648 110421002
Administration related reaction 17.96 9.36 9 166640 306 110422344
Product preparation error 17.86 9.36 46 166603 10833 110411817
Streptococcal infection 17.83 9.36 46 166603 10844 110411806
Sleep disorder due to a general medical condition 17.81 9.36 32 166617 52080 110370570
Injection site joint infection 17.64 9.36 6 166643 73 110422577
Seizure like phenomena 17.54 9.36 20 166629 2421 110420229
Acute respiratory failure 17.51 9.36 182 166467 75078 110347572
Blindness 17.45 9.36 104 166545 36255 110386395
Gastroenteritis viral 17.42 9.36 93 166556 31133 110391517
Skin warm 17.41 9.36 41 166608 9129 110413521
Urinary incontinence 17.29 9.36 129 166520 48458 110374192
Nerve injury 17.28 9.36 45 166604 10668 110411982
Incorrect product formulation administered 17.20 9.36 8 166641 230 110422420
Application site alopecia 17.03 9.36 5 166644 36 110422614
Opisthotonus 16.97 9.36 12 166637 774 110421876
Abortion spontaneous 16.91 9.36 16 166633 34266 110388384
Finger deformity 16.85 9.36 15 166634 33077 110389573
Anterior chamber fibrin 16.82 9.36 8 166641 242 110422408
Pain in extremity 16.80 9.36 583 166066 486535 109936115
Torsade de pointes 16.72 9.36 73 166576 22527 110400123
Pneumocystis jirovecii pneumonia 16.71 9.36 24 166625 42711 110379939
Polyarthritis 16.71 9.36 4 166645 18959 110403691
Meningitis 16.71 9.36 47 166602 11655 110410995
Neuroleptic malignant syndrome 16.68 9.36 16 166633 34043 110388607
Apnoeic attack 16.62 9.36 12 166637 800 110421850
Bladder cancer 16.53 9.36 5 166644 20287 110402363
Removal of foreign body from respiratory tract 16.50 9.36 3 166646 0 110422650
Impaired quality of life 16.48 9.36 89 166560 29928 110392722
Poor quality product administered 16.47 9.36 27 166622 4614 110418036
Retinal haemorrhage 16.46 9.36 41 166608 9460 110413190
Hypoproteinaemia 16.44 9.36 31 166618 5914 110416736
Chondrolysis 16.43 9.36 9 166640 368 110422282
Tremor 16.42 9.36 410 166239 201822 110220828
Cytomegalovirus infection 16.40 9.36 36 166613 54408 110368242
Vitreous disorder 16.13 9.36 9 166640 382 110422268
Skin infection 16.12 9.36 72 166577 22437 110400213
Disease recurrence 16.09 9.36 43 166606 60741 110361909
Ventricular hypokinesia 15.98 9.36 45 166604 11169 110411481
Cancer pain 15.94 9.36 33 166616 6739 110415911
Piloerection 15.89 9.36 12 166637 857 110421793
Postictal state 15.85 9.36 19 166630 2427 110420223
Intraocular pressure increased 15.84 9.36 44 166605 10832 110411818
Syringomyelia 15.80 9.36 8 166641 278 110422372
Painful ejaculation 15.75 9.36 6 166643 103 110422547
Progressive multifocal leukoencephalopathy 15.74 9.36 9 166640 24947 110397703
Axillary nerve injury 15.67 9.36 5 166644 49 110422601
Septic arthritis staphylococcal 15.51 9.36 12 166637 889 110421761
Iron deficiency 15.48 9.36 62 166587 18414 110404236
Ventricular asystole 15.35 9.36 9 166640 420 110422230
Full blood count abnormal 15.33 9.36 39 166610 56013 110366637
Anticholinergic syndrome 15.32 9.36 25 166624 4255 110418395
Bone density decreased 15.22 9.36 56 166593 15986 110406664
Supraventricular tachycardia 15.20 9.36 75 166574 24347 110398303
Road traffic accident 15.20 9.36 97 166552 107301 110315349
Application site vesicles 15.12 9.36 15 166634 1549 110421101
Gastrooesophageal reflux disease 15.08 9.36 186 166463 179790 110242860
Device ineffective 14.96 9.36 7 166642 204 110422446
Oxygen saturation decreased 14.81 9.36 325 166324 156657 110265993
Economic problem 14.61 9.36 24 166625 4107 110418543
Implant site bruising 14.52 9.36 8 166641 331 110422319
Insomnia 14.49 9.36 423 166226 360167 110062483
Clonus 14.46 9.36 37 166612 8679 110413971
Removal of foreign body from throat 14.42 9.36 3 166646 3 110422647
Air embolism 14.35 9.36 10 166639 630 110422020
Post transplant lymphoproliferative disorder 14.35 9.36 3 166646 15610 110407040
Electrocardiogram QRS complex shortened 14.29 9.36 11 166638 809 110421841
Respiratory tract infection viral 14.25 9.36 29 166620 5849 110416801
Treatment noncompliance 14.25 9.36 59 166590 72931 110349719
Application site burn 14.23 9.36 12 166637 1005 110421645
Acute pulmonary oedema 14.22 9.36 57 166592 16939 110405711
Administration site pain 14.16 9.36 11 166638 820 110421830
Supraventricular extrasystoles 14.15 9.36 35 166614 8038 110414612
Hypoventilation 14.13 9.36 35 166614 8046 110414604
Adverse drug reaction 14.10 9.36 97 166552 105462 110317188
Familial periodic paralysis 14.09 9.36 8 166641 351 110422299
Bacterial infection 14.06 9.36 118 166531 45918 110376732
Blood uric acid increased 14.04 9.36 67 166582 21462 110401188
Blood pressure diastolic abnormal 14.01 9.36 11 166638 25804 110396846
Spinal cord ischaemia 13.99 9.36 7 166642 237 110422413
Carotid pulse decreased 13.96 9.36 3 166646 4 110422646
Histamine level increased 13.94 9.36 6 166643 143 110422507
Vitamin D increased 13.90 9.36 11 166638 842 110421808
Application site oedema 13.81 9.36 5 166644 74 110422576
Mucosal erosion 13.68 9.36 19 166630 2805 110419845
Pregnancy 13.61 9.36 36 166613 51031 110371619
Injection site ulcer 13.60 9.36 11 166638 869 110421781
Nail bed tenderness 13.59 9.36 8 166641 376 110422274
Schizophrenia 13.58 9.36 8 166641 21818 110400832
Liver function test increased 13.57 9.36 78 166571 88470 110334180
Decubitus ulcer 13.56 9.36 59 166590 18177 110404473
Obstruction 13.50 9.36 28 166621 5724 110416926
Angioedema 13.48 9.36 216 166433 98284 110324366
Retinal detachment 13.40 9.36 42 166607 11058 110411592
Sepsis 13.30 9.36 612 166037 326734 110095916
Hypertonia 13.24 9.36 35 166614 8371 110414279
Nerve root injury cervical 13.21 9.36 3 166646 6 110422644
Tryptase 13.21 9.36 3 166646 6 110422644
Pupil fixed 13.18 9.36 22 166627 3816 110418834
Injection site joint swelling 13.15 9.36 4 166645 33 110422617
Hiccups 13.13 9.36 46 166603 12823 110409827
Chorea 13.11 9.36 20 166629 3215 110419435
Anal skin tags 13.07 9.36 9 166640 556 110422094
Amnesia 13.05 9.36 99 166550 105309 110317341
Long QT syndrome congenital 13.01 9.36 6 166643 169 110422481
Injection site oedema 13.00 9.36 15 166634 1839 110420811
Induration 12.99 9.36 17 166632 2372 110420278
Blood pressure systolic abnormal 12.97 9.36 11 166638 24839 110397811
Therapy partial responder 12.96 9.36 98 166551 36963 110385687
Oral herpes 12.96 9.36 96 166553 35984 110386666
Application site hypoaesthesia 12.90 9.36 3 166646 7 110422643
Blepharoplasty 12.90 9.36 3 166646 7 110422643
Drug level increased 12.86 9.36 119 166530 47600 110375050
Inflammatory marker increased 12.85 9.36 3 166646 14466 110408184
Uterine hypertonus 12.85 9.36 7 166642 283 110422367
Sinus arrest 12.84 9.36 23 166626 4219 110418431
Deafness bilateral 12.82 9.36 18 166631 2686 110419964
End-tidal CO2 decreased 12.76 9.36 5 166644 93 110422557
Metastases to liver 12.76 9.36 21 166628 35365 110387285
Ocular retrobulbar haemorrhage 12.69 9.36 6 166643 179 110422471
Body dysmorphic disorder 12.67 9.36 8 166641 427 110422223
Vitreous haemorrhage 12.67 9.36 24 166625 4596 110418054
Maternal exposure timing unspecified 12.66 9.36 8 166641 21005 110401645
Incision site rash 12.65 9.36 4 166645 38 110422612
Infusion site nodule 12.64 9.36 8 166641 429 110422221
Electrocardiogram QRS complex 12.61 9.36 3 166646 8 110422642
Application site laceration 12.61 9.36 3 166646 8 110422642
Catecholamine crisis 12.61 9.36 5 166644 96 110422554
Viral infection 12.60 9.36 129 166520 53010 110369640
Type IV hypersensitivity reaction 12.59 9.36 28 166621 6005 110416645
Device infusion issue 12.59 9.36 19 166630 3026 110419624
Electrocardiogram QRS complex abnormal 12.56 9.36 10 166639 772 110421878
Meningitis aseptic 12.52 9.36 38 166611 9832 110412818
Enterobacter pneumonia 12.52 9.36 9 166640 596 110422054
Lethargy 12.36 9.36 204 166445 93372 110329278
Product contamination physical 12.35 9.36 7 166642 306 110422344
Burning sensation 12.35 9.36 159 166490 69053 110353597
Reperfusion arrhythmia 12.33 9.36 7 166642 307 110422343
Carbon dioxide decreased 12.29 9.36 24 166625 4700 110417950
Genital erosion 12.24 9.36 10 166639 801 110421849
Atelectasis 12.24 9.36 96 166553 36616 110386034
Eyelid contusion 12.20 9.36 5 166644 105 110422545
Administration site swelling 12.18 9.36 9 166640 622 110422028
Disseminated intravascular coagulation 12.17 9.36 105 166544 41181 110381469
Vision blurred 12.13 9.36 267 166382 128755 110293895
Testicular torsion 12.11 9.36 3 166646 10 110422640
Exophthalmos 12.09 9.36 16 166633 2257 110420393
Myocardial infarction 12.09 9.36 210 166439 191873 110230777
Pneumonia mycoplasmal 12.07 9.36 14 166635 1727 110420923
Irregular breathing 12.05 9.36 9 166640 632 110422018
Oesophageal adenocarcinoma recurrent 12.04 9.36 4 166645 45 110422605
Tachypnoea 12.04 9.36 101 166548 39294 110383356
Ventricular arrhythmia 12.02 9.36 38 166611 10049 110412601
Blood cholinesterase decreased 12.01 9.36 8 166641 468 110422182
Cholestasis of pregnancy 11.98 9.36 12 166637 1253 110421397
Myelitis 11.82 9.36 19 166630 3194 110419456
Heparin-induced thrombocytopenia 11.80 9.36 41 166608 11383 110411267
Vaginal abscess 11.76 9.36 8 166641 485 110422165
Endotracheal intubation complication 11.74 9.36 10 166639 849 110421801
Acute generalised exanthematous pustulosis 11.73 9.36 64 166585 21600 110401050
Product prescribing error 11.65 9.36 39 166610 51292 110371358
Conjunctival oedema 11.61 9.36 13 166636 1543 110421107
Muscle spasms 11.50 9.36 325 166324 277832 110144818
Oropharyngeal discomfort 11.49 9.36 38 166611 10289 110412361
Hypercapnia 11.48 9.36 40 166609 11119 110411531
Open globe injury 11.43 9.36 6 166643 225 110422425
Repetitive strain injury 11.41 9.36 6 166643 226 110422424
Oedema peripheral 11.40 9.36 393 166256 328267 110094383
Complex regional pain syndrome 11.38 9.36 16 166633 2389 110420261
Respiratory failure 11.37 9.36 414 166235 214918 110207732
Scar 11.35 9.36 53 166596 16828 110405822
Kidney congestion 11.25 9.36 8 166641 521 110422129
Eclampsia 11.23 9.36 7 166642 365 110422285
Anal ulcer 11.23 9.36 14 166635 1862 110420788
Blood pressure systolic increased 11.22 9.36 76 166573 82915 110339735
Tinnitus 11.19 9.36 140 166509 60400 110362250
Jaundice cholestatic 11.19 9.36 4 166645 14604 110408046
Parosmia 11.19 9.36 3 166646 13177 110409473
Vitamin B12 deficiency 11.19 9.36 37 166612 10018 110412632
Hepatocellular injury 11.14 9.36 39 166610 50603 110372047
Brain herniation 11.13 9.36 34 166615 8829 110413821
Diffuse large B-cell lymphoma 11.12 9.36 5 166644 15893 110406757
Heliotrope rash 11.12 9.36 6 166643 238 110422412
Device programming error 11.11 9.36 7 166642 372 110422278
Hepatic cytolysis 11.06 9.36 44 166605 55009 110367641
Left ventricle outflow tract obstruction 11.06 9.36 8 166641 535 110422115
Laboratory test abnormal 11.06 9.36 32 166617 44047 110378603
Lymphopenia 10.95 9.36 28 166621 40142 110382508
Product contamination 10.90 9.36 14 166635 1917 110420733
Hypercalcaemia 10.90 9.36 35 166614 46622 110376028
Oxidative stress 10.88 9.36 4 166645 62 110422588
Application site irritation 10.87 9.36 14 166635 1923 110420727
Injection site reaction 10.86 9.36 84 166565 88986 110333664
Medical device site pain 10.85 9.36 7 166642 388 110422262
Foetal heart rate decreased 10.82 9.36 4 166645 63 110422587
Spinal stroke 10.76 9.36 4 166645 64 110422586
Panniculitis 10.75 9.36 5 166644 15577 110407073
Ear infection 10.73 9.36 143 166506 62589 110360061
Intentional overdose 10.70 9.36 138 166511 132363 110290287
Premature baby 10.66 9.36 23 166626 4832 110417818
Nightmare 10.66 9.36 27 166622 38836 110383814
Immunodeficiency 10.64 9.36 27 166622 38811 110383839
Ecchymosis 10.62 9.36 53 166596 17285 110405365
Purpura 10.60 9.36 68 166581 24320 110398330
Allergy to immunoglobulin therapy 10.58 9.36 5 166644 149 110422501
Harlequin syndrome 10.53 9.36 6 166643 265 110422385
Myokymia 10.52 9.36 5 166644 151 110422499
Cardiac failure congestive 10.52 9.36 162 166487 150838 110271812
Vascular stenosis 10.52 9.36 9 166640 769 110421881
Femoral nerve injury 10.48 9.36 4 166645 69 110422581
Infusion site streaking 10.47 9.36 8 166641 582 110422068
Retrograde amnesia 10.43 9.36 9 166640 778 110421872
Bacteroides infection 10.38 9.36 17 166632 2902 110419748
Bronchoscopy abnormal 10.38 9.36 4 166645 71 110422579
HLA-B*27 positive 10.37 9.36 5 166644 156 110422494
Dysphoria 10.37 9.36 27 166622 6401 110416249
Cholestasis 10.34 9.36 56 166593 64462 110358188
Melaena 10.30 9.36 61 166588 68696 110353954
Behaviour disorder 10.29 9.36 35 166614 9612 110413038
Corneal opacity 10.29 9.36 11 166638 1240 110421410
Reaction to excipient 10.20 9.36 14 166635 2045 110420605
Vulvovaginal swelling 10.19 9.36 8 166641 605 110422045
Post herpetic neuralgia 10.12 9.36 18 166631 3283 110419367
Blood pH decreased 10.12 9.36 22 166627 4647 110418003
Product administered at inappropriate site 10.12 9.36 24 166625 5369 110417281
Accelerated idioventricular rhythm 10.12 9.36 6 166643 286 110422364
Skin disorder 10.09 9.36 104 166545 42809 110379841
Autonomic nervous system imbalance 10.07 9.36 25 166624 5755 110416895
Arachnoiditis 10.07 9.36 10 166639 1034 110421616
Eye infection 10.07 9.36 46 166603 14472 110408178
Injection site ischaemia 10.05 9.36 3 166646 23 110422627
Renal impairment 10.02 9.36 212 166437 188233 110234417
Chondromalacia 10.00 9.36 5 166644 169 110422481
Skin depigmentation 9.97 9.36 11 166638 1285 110421365
Injection site inflammation 9.80 9.36 22 166627 4749 110417901
Hypoalbuminaemia 9.79 9.36 76 166573 28898 110393752
Skin discolouration 9.76 9.36 115 166534 48931 110373719
Brugada syndrome 9.74 9.36 12 166637 1576 110421074
Oesophageal injury 9.73 9.36 6 166643 307 110422343
Procedural anxiety 9.73 9.36 9 166640 852 110421798
Hypoglycaemia 9.72 9.36 120 166529 115984 110306666
Anorectal disorder 9.72 9.36 16 166633 2743 110419907
Vasospasm 9.69 9.36 12 166637 1584 110421066
Pancytopenia 9.69 9.36 241 166408 209372 110213278
Lung opacity 9.68 9.36 39 166610 11613 110411037
Device expulsion 9.66 9.36 20 166629 30871 110391779
Posterior capsule rupture 9.63 9.36 3 166646 27 110422623
Post procedural cellulitis 9.63 9.36 4 166645 87 110422563
Vitreous floaters 9.62 9.36 33 166616 9101 110413549
Orbital infection 9.61 9.36 5 166644 184 110422466
Post procedural fever 9.58 9.36 8 166641 661 110421989
Speech disorder 9.58 9.36 138 166511 61431 110361219
Infusion site inflammation 9.55 9.36 7 166642 478 110422172
Iatrogenic injury 9.53 9.36 12 166637 1611 110421039
Aortic stenosis 9.52 9.36 42 166607 13017 110409633
Multiple-drug resistance 9.52 9.36 4 166645 13231 110409419
Coronary artery disease 9.51 9.36 66 166583 71624 110351026
Diabetic ketoacidosis 9.51 9.36 32 166617 42026 110380624
Blood chloride increased 9.50 9.36 26 166623 6346 110416304
Oxygen therapy 9.50 9.36 20 166629 4133 110418517
Incision site pain 9.49 9.36 17 166632 3118 110419532
Product complaint 9.49 9.36 44 166605 13928 110408722
Application site pruritus 9.47 9.36 20 166629 4140 110418510
Peritonitis 9.46 9.36 22 166627 32585 110390065
Respiratory tract oedema 9.46 9.36 10 166639 1113 110421537
Symblepharon 9.46 9.36 7 166642 485 110422165
Intra-ocular injection complication 9.42 9.36 4 166645 92 110422558
Infusion site discolouration 9.42 9.36 9 166640 888 110421762
Uterine haemorrhage 9.39 9.36 18 166631 3476 110419174
Liver function test abnormal 9.39 9.36 63 166586 68887 110353763
Strabismus 9.37 9.36 18 166631 3481 110419169
Myotonic dystrophy 9.37 9.36 5 166644 194 110422456

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Methaemoglobinaemia 59.88 37.64 15 71 134 113733

Pharmacologic Action:

SourceCodeDescription
ATC C01BB01 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
ANTIARRHYTHMICS, CLASS I AND III
Antiarrhythmics, class Ib
ATC C05AD01 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Local anesthetics
ATC D04AB01 DERMATOLOGICALS
ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
Anesthetics for topical use
ATC N01BB02 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, LOCAL
Amides
ATC N01BB52 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, LOCAL
Amides
ATC R02AD02 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Anesthetics, local
ATC S01HA07 SENSORY ORGANS
OPHTHALMOLOGICALS
LOCAL ANESTHETICS
Local anesthetics
ATC S02DA01 SENSORY ORGANS
OTOLOGICALS
OTHER OTOLOGICALS
Analgesics and anesthetics
FDA CS M0000897 Amides
FDA EPC N0000175426 Antiarrhythmic
MeSH PA D000777 Anesthetics
MeSH PA D000779 Anesthetics, Local
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018689 Sensory System Agents
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D061567 Voltage-Gated Sodium Channel Blockers
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35441 antiinfective agent
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:36333 local anaesthetic
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:50646 bone density conservation agent
CHEBI has role CHEBI:51177 antitussive
CHEBI has role CHEBI:53784 antispasmodic drug
CHEBI has role CHEBI:55324 gastrointestinal drug
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:73336 vulnerary
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:88188 drug allergen
FDA EPC N0000175682 Amide Local Anesthetic
FDA PE N0000175976 Local Anesthesia

Related Drugs by ATC class:

C01BB Antiarrhythmics, class Ib 3 drugs
aprindinemexiletinetocainide
C05AD Local anesthetics 6 drugs
benzocainecinchocaineoxetacainepramocaineprocainetetracaine
D04AB Anesthetics for topical use 6 drugs
benzocainecinchocaineoxybuprocainepramocainequinisocainetetracaine
N01BB Amides 10 drugs
articainebupivacainebutanilicainecinchocaineetidocainelevobupivacainemeloxicammepivacaineprilocaineropivacaine
R02AD Anesthetics, local 4 drugs
ambroxolbenzocainecocainedyclonine
S01HA Local anesthetics 7 drugs
chloroprocainecinchocainecocaineoxybuprocaineprocaineproparacainetetracaine
S02DA Analgesics and anesthetics 3 drugs
cinchocainecocainephenazone

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Postherpetic neuralgia indication 2177002
Neuralgia indication 16269008
Urethritis indication 31822004 DOID:1343
Premature ejaculation indication 44001008 DOID:13709
Ventricular arrhythmia indication 44103008
Hemorrhoids indication 70153002 DOID:9746
Infestation by Phthirus pubis indication 71011005 DOID:13760
Pediculosis capitis indication 81000006 DOID:5501
Pruritus ani indication 90446007
Infestation by Sarcoptes scabiei var hominis indication 128869009 DOID:8295
Local anesthetic intrathecal block indication 231249005
Skin irritation indication 367466007
Local anesthesia indication 386761002
Itching of skin indication 418363000
Local Anesthesia for Urethral Pain indication
Suppression of the Gag Reflex indication
Local Anesthesia for Ophthalmologic Procedure indication
Mouth Irritation indication
Prevent Minor Bacterial Skin Infection indication
Minor Skin Wound Pain indication
Regional Anesthesia for Ophthalmologic Surgery indication
Local Anesthesia for Endotracheal Intubation indication
Neuropathic pain off-label use 247398009
Inflammatory dermatosis off-label use 703938007
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Alcoholism contraindication 7200002
Psoriasis contraindication 9014002 DOID:8893
Bacterial septicemia contraindication 10001005 DOID:0040085
Sinus tachycardia contraindication 11092001
Measles contraindication 14189004 DOID:8622
Lowered convulsive threshold contraindication 19260006
Cirrhosis of liver contraindication 19943007 DOID:5082
Myocardial infarction contraindication 22298006 DOID:5844
Atopic dermatitis contraindication 24079001 DOID:3310
Abscess of intestine contraindication 24557004
Acute tuberculosis contraindication 25629007
Complete atrioventricular block contraindication 27885002
Shock contraindication 27942005
Hypovolemia contraindication 28560003
Parkinsonism contraindication 32798002
Hyperthyroidism contraindication 34486009 DOID:7998
Gastrointestinal fistula contraindication 37831005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Stokes-Adams syndrome contraindication 46935006
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Atrial fibrillation contraindication 49436004 DOID:0060224
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Sinus bradycardia contraindication 49710005
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Corneal opacity contraindication 64634000
Blood coagulation disorder contraindication 64779008 DOID:1247
Osteoporosis contraindication 64859006 DOID:11476
Cerebral arteriosclerosis contraindication 65312002
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Factor II deficiency contraindication 73975000
Wolff-Parkinson-White pattern contraindication 74390002 DOID:384
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Open-angle glaucoma contraindication 84494001 DOID:1067
Herpes simplex contraindication 88594005 DOID:8566
Cardiogenic shock contraindication 89138009
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Corneal ulcer contraindication 91514001 DOID:8463
Disorder of skin contraindication 95320005 DOID:37
Disorder of mucous membrane contraindication 95351003
Anemia due to enzyme deficiency contraindication 111577008
Magnetic resonance imaging contraindication 113091000
Open wound contraindication 125643001
Seizure disorder contraindication 128613002
Bleeding contraindication 131148009
Ophthalmic herpes simplex contraindication 186542001
Angina pectoris contraindication 194828000
Primary dilated cardiomyopathy contraindication 195021004
Partial atrioventricular block contraindication 195039008
Heart block contraindication 233916004
Anastomosis of intestine contraindication 235407009
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Sepsis syndrome contraindication 238150007
Telangiectasia disorder contraindication 247479008
Diverticulitis of gastrointestinal tract contraindication 271366000
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Varicella-zoster virus infection contraindication 309465005
Deficiency of cholinesterase contraindication 360607009
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Breastfeeding (mother) contraindication 413712001
Disorder of coronary artery contraindication 414024009
Denuded skin contraindication 418242004
Uncontrolled Epilepsy contraindication
Intracerebral Mass contraindication
Lidocaine Toxicity contraindication
Reduced Hepatic Blood Flow contraindication




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Urinary tract infections caused by Hemolytic Staphylococcus species Indication
Dogs Urinary tract infections caused by Streptococcus species Indication
Dogs Bacterial pulmonary infections caused by Brucella bronchiseptica Indication
Dogs Bacterial pulmonary infections caused by Streptococcus pyogenes Indication
Dogs Bacterial pulmonary infections caused by Staphylococcus aureus Indication
Dogs Secondary bacterial infections caused by Micrococcus pyogenes var albus Indication
Dogs Secondary bacterial infections caused by Brucella bronchiseptica Indication
Dogs Secondary bacterial infections caused by Streptococcus species Indication

🐶 Veterinary products

ProductApplicantIngredients
Liquamycin Intramuscular Zoetis Inc. 2
Aquachel 100 mg Zoetis Inc. 2
Tributame Euthanasia Solution Cronus Pharma Specialities India Private Limited 3

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.4 acidic
pKa2 7.92 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
3.5% AKTEN THEA PHARMA N022221 Oct. 7, 2008 RX GEL OPHTHALMIC 8759401 July 24, 2026 METHOD OF INDUCING TOPICAL ANESTHESIA IN THE EYE
0.5MG ZINGO POWDER PHARMS N022114 Aug. 16, 2007 RX SYSTEM INTRADERMAL 8540665 Oct. 22, 2029 ZINGO INTRADERMAL INJECTION SYSTEM IS A DRUG DELIVERY SYSTEM THAT IS CAPABLE OF DELIVERING FINE DRY POWDERED LIDOCAINE HYDROCHLORIDE MONOHYDRATE FOR LOCAL ANESTHETIC ACTION
7%;7% PLIAGLIS CRESCITA THERAP N021717 June 29, 2006 RX CREAM TOPICAL 12558328 Jan. 14, 2031 A METHOD OF APPLYING A SOLID FORMING LOCAL ANESTHETIC FORMULATION TO A SKIN SURFACE, ALLOWING THE LAYER TO FORM A COHESIVE FILM, AND REMOVING THE FILM LAYER BY PEELING FROM THE SKIN SURFACE AS ONE, TWO OR THREE LARGE PIECES
1.8% ZTLIDO SCILEX PHARMS N207962 Feb. 28, 2018 RX PATCH TOPICAL 11786455 May 10, 2031 METHOD FOR RELIEVING THE PAIN ASSOCIATED WITH POST-HERPETIC NEURALGIA
1.8% ZTLIDO SCILEX PHARMS N207962 Feb. 28, 2018 RX PATCH TOPICAL 11793766 May 10, 2031 METHOD FOR RELIEVING THE PAIN ASSOCIATED WITH POST-HERPETIC NEURALGIA
1.8% ZTLIDO SCILEX PHARMS N207962 Feb. 28, 2018 RX PATCH TOPICAL 9925264 May 10, 2031 METHOD FOR RELIEVING THE PAIN ASSOCIATED WITH POST-HERPETIC NEURALGIA
0.5MG ZINGO POWDER PHARMS N022114 Aug. 16, 2007 RX SYSTEM INTRADERMAL 9358338 April 27, 2035 ZINGO IS A POWDER INTRADERMAL SYSTEM THAT IS CAPABLE OF DELIVERING FINE DRY POWDERED LIDOCAINE HYDROCHLORIDE MONOHYDRATE FOR LOCAL ANESTHETIC ACTION
0.5MG ZINGO POWDER PHARMS N022114 Aug. 16, 2007 RX SYSTEM INTRADERMAL 9370622 Sept. 28, 2035 ZINGO IS A POWDER INTRADERMAL SYSTEM THAT IS CAPABLE OF DELIVERING FINE DRY POWDERED LIDOCAINE HYDROCHLORIDE MONOHYDRATE FOR LOCAL ANESTHETIC ACTION

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
10% BONDLIDO MEDRX USA N215029 Sept. 24, 2025 RX SYSTEM TOPICAL Sept. 24, 2028 NEW PRODUCT

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER Kd 4.80 IUPHAR CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel BLOCKER UNKNOWN CHEMBL
Sodium channel protein type 3 subunit alpha Ion channel BLOCKER IC50 4.98 CHEMBL CHEMBL
Sodium channel protein type 4 subunit alpha Ion channel BLOCKER IC50 5.70 CHEMBL CHEMBL
Sodium channel protein type 9 subunit alpha Ion channel BLOCKER IC50 4.54 CHEMBL CHEMBL
Sodium channel protein type 10 subunit alpha Ion channel BLOCKER UNKNOWN CHEMBL
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 Ion channel IC50 3.56 WOMBAT-PK
Acetylcholine receptor Ion channel IC50 4.96 WOMBAT-PK
5-hydroxytryptamine receptor 3A Ion channel IC50 3.30 WOMBAT-PK
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER IC50 4.20 IUPHAR
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.25 CHEMBL
Sodium channel protein type X alpha subunit Ion channel BLOCKER IC50 4 IUPHAR

External reference:

IDSource
4018262 VUID
N0000146592 NUI
D00358 KEGG_DRUG
6108-05-0 SECONDARY_CAS_RN
73-78-9 SECONDARY_CAS_RN
4017992 VANDF
4018262 VANDF
C0023660 UMLSCUI
CHEBI:6456 CHEBI
CHEMBL79 ChEMBL_ID
DB00281 DRUGBANK_ID
CHEMBL1200409 ChEMBL_ID
D008012 MESH_DESCRIPTOR_UI
3676 PUBCHEM_CID
2623 IUPHAR_LIGAND_ID
4202 INN_ID
98PI200987 UNII
1299236 RXNORM
14031 MMSL
4977 MMSL
4978 MMSL
73102 MMSL
9242 MMSL
d00059 MMSL
000626 NDDF
000627 NDDF
001350 NDDF
001351 NDDF
1269131003 SNOMEDCT_US
387480006 SNOMEDCT_US
61773008 SNOMEDCT_US
82573000 SNOMEDCT_US
LQZ PDB_CHEM_ID
98PI200987 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lidocaine Viscous HUMAN PRESCRIPTION DRUG LABEL 1 0054-0548 SOLUTION 20 mg ORAL ANDA 20 sections
Lidocaine Viscous HUMAN PRESCRIPTION DRUG LABEL 1 0054-3500 SOLUTION 20 mg ORAL ANDA 20 sections
Lidocaine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-3505 SOLUTION 40 mg TOPICAL ANDA 18 sections
LIDOCAINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0116-4025 SOLUTION 40 mg TOPICAL ANDA 22 sections
Lidocaine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0116-4027 SOLUTION 20 mg ORAL ANDA 22 sections
Lidocaine Viscous HUMAN PRESCRIPTION DRUG LABEL 1 0121-0903 SOLUTION 20 mg ORAL ANDA 20 sections
Lidocaine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0950 SOLUTION 20 mg ORAL ANDA 19 sections
Lidocaine Pain Relief HUMAN OTC DRUG LABEL 1 0121-0970 PATCH 560 mg TOPICAL OTC Monograph Drug 14 sections
Lidocaine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-0972 SOLUTION 40 mg TOPICAL ANDA 21 sections
Lidocaine and Prilocaine HUMAN PRESCRIPTION DRUG LABEL 2 0121-1002 CREAM 25 mg TOPICAL ANDA 26 sections
Lidocaine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0121-4950 SOLUTION 20 mg ORAL ANDA 19 sections
ABREVA Rapid Pain Relief HUMAN OTC DRUG LABEL 2 0135-0400 GEL 40 mg TOPICAL OTC Monograph Drug 14 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 1 0143-9172 INJECTION, SOLUTION 10 mg INFILTRATION ANDA 20 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 1 0143-9173 INJECTION, SOLUTION 20 mg INFILTRATION ANDA 20 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 1 0143-9575 INJECTION, SOLUTION 20 mg INFILTRATION ANDA 20 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 1 0143-9576 INJECTION, SOLUTION 20 mg INFILTRATION ANDA 20 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 1 0143-9577 INJECTION, SOLUTION 10 mg INFILTRATION ANDA 20 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 1 0143-9578 INJECTION, SOLUTION 10 mg INFILTRATION ANDA 20 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 1 0143-9579 INJECTION, SOLUTION 10 mg INFILTRATION ANDA 20 sections
Lidocaine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9594 INJECTION, SOLUTION 20 mg EPIDURAL ANDA 25 sections
Lidocaine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0143-9595 INJECTION, SOLUTION 10 mg EPIDURAL ANDA 25 sections
Lidocaine HUMAN PRESCRIPTION DRUG LABEL 1 0168-0204 OINTMENT 50 mg TOPICAL ANDA 21 sections
Lidocaine and Prilocaine HUMAN PRESCRIPTION DRUG LABEL 2 0168-0357 CREAM 25 mg TOPICAL ANDA 24 sections
LIDOCAINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0264-9376 INJECTION 10 mg INFILTRATION ANDA 12 sections
LIDOCAINE HCl and EPINEPHRINE HUMAN PRESCRIPTION DRUG LABEL 2 0264-9378 INJECTION 15 mg EPIDURAL ANDA 12 sections
Lidocaine Hydrochloride and Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9594 INJECTION, SOLUTION 0.40 g INTRAVENOUS NDA 23 sections
Lidocaine Hydrochloride and Dextrose HUMAN PRESCRIPTION DRUG LABEL 2 0264-9598 INJECTION, SOLUTION 0.80 g INTRAVENOUS NDA 23 sections
HurriCaine One HUMAN OTC DRUG LABEL 2 0283-1024 SPRAY 40 mg TOPICAL OTC Monograph Drug 12 sections
Lidocaine Hydrochloride and Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0338-0409 INJECTION, SOLUTION 4 mg INTRAVENOUS NDA 24 sections
Lidocaine Hydrochloride and Dextrose HUMAN PRESCRIPTION DRUG LABEL 1 0338-0411 INJECTION, SOLUTION 8 mg INTRAVENOUS NDA 24 sections