lamotrigine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
sodium channel blockers, signal transduction modulators 1540 84057-84-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lamictal
  • lamotrigine
  • lamitrin
  • lamotrigin
  • BW 430C
A phenyltriazine compound, sodium and calcium channel blocker that is used for the treatment of SEIZURES and BIPOLAR DISORDER.
  • Molecular weight: 256.09
  • Formula: C9H7Cl2N5
  • CLOGP: 2.53
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 90.71
  • ALOGS: -2.72
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.30 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.48 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 27.89 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 98 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
fu (Fraction unbound in plasma) 0.37 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.175 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.216 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 64.269 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 1.542 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 43.310 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 52.530 % High 1
herg hERG pIC50 4.387 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 1.901 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 3.048 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 44.100 % High 1
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,FLT3,GRK2,ITK,JAK1,MAP3K10,MAP3K21,MAP4K1,MAPK10,MAPK7,MET,MTOR,NTRK2,PDK2,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,SIK3,STK33,TEK,TGFBR1,ULK1 39
kinase-selectivity-class EIF2AK3,MAP3K21,MAPK7,PIK3CD 4
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.641 High 1
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.675 High 1
mh-clint Mouse hepatocyte intrinsic clearance 1.352 High 1
mppb Mouse plasma protein binding (% unbound) 53.560 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.869 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 1 High 1
pppb Pig plasma protein binding (% unbound) 54.420 % High 1
rat-kpuu-brain Rat brain Kpuu 0.571 % High 1
rh-clint Rat hepatocyte intrinsic clearance 1.968 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 92.980 % High 1
rppb Rat plasma protein binding (% unbound) 44.840 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 648.634 uM High 1

Approvals:

DateAgencyCompanyOrphan
Dec. 27, 1994 FDA GLAXOSMITHKLINE LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 2594.74 9.86 2489 221471 150140 90254347
Drug reaction with eosinophilia and systemic symptoms 2446.86 9.86 1446 222514 41312 90363175
Completed suicide 1657.75 9.86 1915 222045 143143 90261344
Stevens-Johnson syndrome 1518.58 9.86 931 223029 28445 90376042
Intentional overdose 1198.03 9.86 1313 222647 92521 90311966
Toxicity to various agents 1101.99 9.86 2288 221672 285558 90118929
Exposure during pregnancy 1085.09 9.86 2038 221922 236372 90168115
Epilepsy 1076.70 9.86 1166 222794 81040 90323447
Generalised tonic-clonic seizure 850.66 9.86 699 223261 34204 90370283
Suicide attempt 842.92 9.86 985 222975 74414 90330073
Toxic epidermal necrolysis 711.33 9.86 612 223348 31916 90372571
Product substitution issue 706.50 9.86 480 223480 17528 90386959
Abortion spontaneous 608.74 9.86 709 223251 53347 90351140
Suicidal ideation 590.96 9.86 817 223143 73038 90331449
Intentional self-injury 526.92 9.86 494 223466 28840 90375647
Drug interaction 522.51 9.86 1686 222274 274767 90129720
Somnolence 476.44 9.86 1362 222598 207722 90196765
Overdose 469.22 9.86 1135 222825 156574 90247913
Foetal exposure during pregnancy 466.12 9.86 553 223407 42422 90362065
Blepharospasm 464.13 9.86 627 223333 54818 90349669
Status epilepticus 430.77 9.86 364 223596 18510 90385977
Nystagmus 370.63 9.86 228 223732 6999 90397488
Depression 357.59 9.86 1581 222379 299020 90105467
Petit mal epilepsy 351.42 9.86 193 223767 4765 90399722
Taste disorder 348.86 9.86 580 223380 60966 90343521
Multiple-drug resistance 347.89 9.86 225 223735 7551 90396936
Dyspnoea 346.19 9.86 1075 222885 879880 89524607
Ataxia 333.95 9.86 309 223651 17733 90386754
Onychomadesis 309.67 9.86 469 223491 45529 90358958
Infection 307.00 9.86 266 223694 361828 90042659
Mania 305.19 9.86 264 223696 13860 90390627
Aggression 303.85 9.86 352 223608 26316 90378171
Product quality issue 290.34 9.86 620 223340 78705 90325782
Sudden unexplained death in epilepsy 288.52 9.86 84 223876 324 90404163
Diarrhoea 287.66 9.86 1270 222690 937920 89466567
Pain 282.35 9.86 1386 222574 994955 89409532
Sinusitis 269.63 9.86 270 223690 342818 90061669
Coma 266.17 9.86 568 223392 72064 90332423
Anaemia 264.49 9.86 289 223671 352513 90051974
Drug level increased 261.83 9.86 333 223627 27429 90377058
Rash maculo-papular 259.59 9.86 406 223554 40527 90363960
Tremor 257.78 9.86 899 223061 152274 90252213
Nail disorder 255.73 9.86 495 223465 58572 90345915
Maternal exposure during pregnancy 252.63 9.86 1638 222322 358425 90046062
Agitation 248.50 9.86 527 223433 66571 90337916
Arthralgia 245.29 9.86 1041 222919 777481 89627006
Irritability 239.17 9.86 363 223597 35299 90369188
Focal dyscognitive seizures 235.64 9.86 127 223833 3017 90401470
Back injury 230.96 9.86 414 223546 46208 90358279
Serotonin syndrome 230.88 9.86 369 223591 37518 90366969
Maternal exposure during breast feeding 230.25 9.86 160 223800 6060 90398427
Back pain 229.86 9.86 267 223693 316908 90087579
Fatigue 221.39 9.86 1810 222150 1152213 89252274
Breast cancer stage III 220.85 9.86 579 223381 83868 90320619
Cough 220.72 9.86 357 223603 368605 90035882
Lymphadenopathy 217.25 9.86 399 223561 45376 90359111
Live birth 205.45 9.86 541 223419 78566 90325921
Oral mucosa erosion 204.63 9.86 91 223869 1398 90403089
Pneumonia 204.61 9.86 847 223113 637212 89767275
Partial seizures 203.72 9.86 158 223802 7102 90397385
Drug eruption 202.38 9.86 335 223625 35072 90369415
Disease progression 201.00 9.86 68 223892 156547 90247940
Memory impairment 198.05 9.86 988 222972 196256 90208231
Onychomycosis 195.59 9.86 340 223620 37036 90367451
Chest pain 193.29 9.86 307 223653 319338 90085149
Diplopia 186.52 9.86 288 223672 28426 90376061
Bipolar disorder 186.19 9.86 164 223796 8821 90395666
Anticonvulsant drug level decreased 184.22 9.86 83 223877 1317 90403170
Joint swelling 181.35 9.86 637 223323 502663 89901824
Atrial septal defect 180.11 9.86 155 223805 8079 90396408
Febrile neutropenia 179.82 9.86 83 223877 158266 90246221
Selective eating disorder 176.79 9.86 91 223869 1962 90402525
Rheumatoid factor positive 174.21 9.86 104 223856 171546 90232941
Arthritis 171.75 9.86 100 223860 167215 90237272
Myoclonic epilepsy 169.29 9.86 82 223878 1545 90402942
Sleep disorder due to general medical condition, insomnia type 166.67 9.86 55 223905 128639 90275848
Lip erosion 164.83 9.86 74 223886 1164 90403323
Malignant neoplasm progression 164.68 9.86 32 223928 106838 90297649
Atrial fibrillation 162.98 9.86 63 223897 133548 90270939
Abnormal behaviour 159.82 9.86 236 223724 22392 90382095
Gastrooesophageal reflux disease 159.79 9.86 823 223137 165514 90238973
Cardio-respiratory arrest 157.06 9.86 425 223535 62715 90341772
Blood pressure increased 153.90 9.86 156 223804 197061 90207426
Abortion induced 150.89 9.86 166 223794 11722 90392765
Asthma 150.72 9.86 228 223732 241932 90162555
Myoclonus 150.15 9.86 210 223750 18958 90385529
Adverse reaction 146.07 9.86 263 223697 29449 90375038
Extrapyramidal disorder 145.02 9.86 190 223770 16113 90388374
Neuropathy peripheral 144.68 9.86 79 223881 136891 90267596
Poisoning 144.23 9.86 183 223777 15034 90389453
Electrocardiogram QRS complex prolonged 144.08 9.86 130 223830 7218 90397269
Ventricular septal defect 143.78 9.86 114 223846 5293 90399194
Erythema multiforme 143.46 9.86 164 223796 12082 90392405
Product label confusion 142.58 9.86 225 223735 22625 90381862
Obsessive-compulsive disorder 141.80 9.86 105 223855 4399 90400088
Psychotic disorder 140.41 9.86 266 223694 30964 90373523
Disturbance in attention 138.79 9.86 338 223622 46771 90357716
Discomfort 138.64 9.86 294 223666 274041 90130446
Facet joint syndrome 137.44 9.86 544 223416 97845 90306642
Migraine 136.88 9.86 872 223088 189520 90214967
Anticonvulsant drug level increased 135.37 9.86 72 223888 1664 90402823
Hyperreflexia 134.93 9.86 120 223840 6537 90397950
Tardive dyskinesia 134.21 9.86 150 223810 10780 90393707
Rash morbilliform 133.79 9.86 97 223863 3932 90400555
Haemophagocytic lymphohistiocytosis 132.63 9.86 177 223783 15282 90389205
Pain in extremity 130.94 9.86 620 223340 449909 89954578
Death 130.53 9.86 632 223328 455919 89948568
Cardiac failure congestive 128.10 9.86 42 223918 98652 90305835
Eosinophilic myocarditis 127.79 9.86 52 223908 633 90403854
Clonus 127.31 9.86 109 223851 5641 90398846
Obesity 126.74 9.86 557 223403 104950 90299537
Acute kidney injury 126.66 9.86 389 223571 319998 90084489
Pleurothotonus 126.13 9.86 63 223897 1272 90403215
Aura 125.61 9.86 61 223899 1156 90403331
Peripheral venous disease 124.54 9.86 473 223487 83448 90321039
Suspected suicide 123.86 9.86 135 223825 9433 90395054
Conjunctival hyperaemia 123.15 9.86 84 223876 3085 90401402
Hyperthermia 118.69 9.86 137 223823 10198 90394289
Drug-induced liver injury 118.67 9.86 490 223470 89828 90314659
Haemoglobin decreased 118.67 9.86 135 223825 161821 90242666
Gastrointestinal haemorrhage 117.85 9.86 38 223922 90210 90314277
Hypersensitivity 115.61 9.86 655 223305 454022 89950465
Cardiac arrest 114.86 9.86 539 223421 104396 90300091
Toxic skin eruption 113.54 9.86 166 223794 15608 90388879
Drug level decreased 113.46 9.86 130 223830 9600 90394887
Akathisia 113.44 9.86 139 223821 11020 90393467
Infarction 110.34 9.86 77 223883 2936 90401551
Constipation 107.59 9.86 345 223615 280050 90124437
Suicidal behaviour 104.90 9.86 73 223887 2771 90401716
Behaviour disorder 102.90 9.86 88 223872 4547 90399940
C-reactive protein increased 102.81 9.86 784 223176 180605 90223882
Oedema peripheral 102.01 9.86 313 223647 257602 90146885
Bronchitis 101.02 9.86 138 223822 152789 90251698
Maternal drugs affecting foetus 100.68 9.86 91 223869 5064 90399423
Delusion 100.13 9.86 146 223814 13694 90390793
Rash 99.21 9.86 2621 221339 793479 89611008
Hyperkalaemia 98.93 9.86 20 223940 64944 90339543
Oedema 97.56 9.86 219 223741 200076 90204411
Meningitis aseptic 97.30 9.86 101 223859 6672 90397815
Urinary tract infection 96.91 9.86 407 223553 305225 90099262
Face oedema 96.75 9.86 192 223768 23126 90381361
Wound infection 96.32 9.86 518 223442 105884 90298603
Bursitis 95.83 9.86 605 223355 131049 90273438
Infusion site reaction 95.47 9.86 170 223790 18869 90385618
Cross sensitivity reaction 95.36 9.86 69 223891 2788 90401699
Blood pressure systolic increased 95.27 9.86 15 223945 58330 90346157
Finger deformity 94.74 9.86 234 223726 32663 90371824
Vertigo 94.28 9.86 382 223578 69429 90335058
Depressed level of consciousness 94.14 9.86 393 223567 72391 90332096
Pruritus 94.09 9.86 870 223090 540655 89863832
Injection site pain 93.82 9.86 179 223781 173520 90230967
Dyskinesia 92.94 9.86 248 223712 36286 90368201
Sedation 92.74 9.86 296 223664 47875 90356612
Anticonvulsant drug level above therapeutic 92.00 9.86 39 223921 530 90403957
Dyspnoea exertional 91.66 9.86 32 223928 72256 90332231
Altered state of consciousness 91.56 9.86 225 223735 31307 90373180
Electroencephalogram abnormal 91.41 9.86 78 223882 4018 90400469
Neuroleptic malignant syndrome 90.55 9.86 146 223814 14950 90389537
Cerebrovascular accident 90.46 9.86 103 223857 123430 90281057
Hypercholesterolaemia 89.85 9.86 489 223471 100403 90304084
Chronic obstructive pulmonary disease 89.71 9.86 35 223925 73794 90330693
Anger 89.64 9.86 138 223822 13582 90390905
Weight decreased 89.28 9.86 561 223399 379349 90025138
Lip dry 88.35 9.86 487 223473 100468 90304019
Caesarean section 88.22 9.86 162 223798 18415 90386072
Dizziness 87.69 9.86 1988 221972 587296 89817191
Dehydration 87.24 9.86 222 223738 194225 90210262
Camptocormia 86.19 9.86 31 223929 262 90404225
Hepatitis 84.59 9.86 373 223587 70366 90334121
Herpes zoster 84.45 9.86 66 223894 94578 90309909
Stillbirth 84.36 9.86 98 223862 7345 90397142
Anxiety 84.27 9.86 1151 222809 308621 90095866
Partial seizures with secondary generalisation 84.02 9.86 35 223925 454 90404033
Dissociation 83.90 9.86 93 223867 6622 90397865
Productive cough 83.50 9.86 43 223917 77020 90327467
Confusional state 82.96 9.86 1378 222582 384827 90019660
Bipolar I disorder 82.84 9.86 56 223904 2026 90402461
Malaise 82.83 9.86 988 222972 584998 89819489
Exposure via breast milk 82.07 9.86 58 223902 2257 90402230
Peripheral swelling 81.88 9.86 641 223319 412465 89992022
Mydriasis 81.73 9.86 139 223821 14873 90389614
Infusion related reaction 81.54 9.86 649 223311 416131 89988356
Nasopharyngitis 81.48 9.86 630 223330 406474 89998013
Eosinophilia 81.16 9.86 202 223758 28331 90376156
Neovascularisation 79.97 9.86 50 223910 1580 90402907
Myocardial infarction 79.07 9.86 87 223873 105885 90298602
Chest discomfort 78.81 9.86 138 223822 138227 90266260
Atonic seizures 78.55 9.86 39 223921 777 90403710
Fluid retention 77.88 9.86 62 223898 88029 90316458
Injection site erythema 77.85 9.86 77 223883 98425 90306062
Abdominal discomfort 77.73 9.86 779 223181 476549 89927938
Electrocardiogram QT prolonged 77.69 9.86 370 223590 72086 90332401
Cardiac failure 77.27 9.86 94 223866 109402 90295085
Muscle rigidity 77.25 9.86 132 223828 14177 90390310
Psychomotor retardation 77.18 9.86 76 223884 4713 90399774
Mood altered 77.03 9.86 146 223814 16998 90387489
Tonic convulsion 77.03 9.86 50 223910 1688 90402799
Cognitive disorder 77.03 9.86 358 223602 69049 90335438
Unresponsive to stimuli 76.83 9.86 238 223722 37883 90366604
Respiratory disorder neonatal 76.46 9.86 46 223914 1355 90403132
Oculogyric crisis 76.27 9.86 57 223903 2422 90402065
Talipes 76.10 9.86 49 223911 1631 90402856
Mood swings 75.92 9.86 162 223798 20540 90383947
Swollen joint count increased 74.81 9.86 99 223861 111107 90293380
Hip arthroplasty 74.75 9.86 48 223912 76160 90328327
Alopecia 74.50 9.86 823 223137 494248 89910239
Depressed mood 74.44 9.86 283 223677 49939 90354548
Small for dates baby 74.34 9.86 76 223884 4931 90399556
Neck pain 73.41 9.86 508 223452 113455 90291032
Upper respiratory tract infection 73.06 9.86 128 223832 128190 90276297
Neutropenia 72.82 9.86 297 223663 224607 90179880
Plasma cell myeloma 72.64 9.86 8 223952 40820 90363667
Hypomania 71.97 9.86 99 223861 8798 90395689
Renal impairment 71.78 9.86 93 223867 105328 90299159
Macular degeneration 71.35 9.86 6 223954 37964 90366523
COVID-19 71.02 9.86 199 223761 168644 90235843
Respiratory arrest 70.91 9.86 212 223748 33099 90371388
Sopor 70.65 9.86 175 223785 24469 90380018
Poisoning deliberate 69.91 9.86 137 223823 16349 90388138
Coeliac disease 69.13 9.86 255 223705 44355 90360132
Psychomotor hyperactivity 68.91 9.86 118 223842 12695 90391792
Drug dose titration not performed 68.74 9.86 35 223925 737 90403750
Diverticulitis 68.62 9.86 14 223946 45173 90359314
Contusion 68.11 9.86 354 223606 250862 90153625
Knee arthroplasty 68.10 9.86 63 223897 83119 90321368
Influenza 68.02 9.86 152 223808 139112 90265375
Drug abuse 67.92 9.86 391 223569 81956 90322531
Nausea 67.82 9.86 2160 221800 1108156 89296331
Sepsis 67.03 9.86 224 223736 179590 90224897
Pain in jaw 66.67 9.86 18 223942 47967 90356520
Enanthema 66.36 9.86 30 223930 480 90404007
Colitis 65.99 9.86 46 223914 69896 90334591
Hallucination, auditory 65.63 9.86 131 223829 15844 90388643
Nasal congestion 65.01 9.86 66 223894 83348 90321139
Cellulitis 64.88 9.86 78 223882 91259 90313228
Thrombosis 64.19 9.86 52 223908 73199 90331288
Epileptic aura 63.85 9.86 18 223942 60 90404427
Haematochezia 63.83 9.86 49 223911 70864 90333623
Mental impairment 63.82 9.86 133 223827 16587 90387900
Trichiasis 63.72 9.86 20 223940 105 90404382
Hypogammaglobulinaemia 63.70 9.86 103 223857 10571 90393916
Liver function test increased 63.64 9.86 393 223567 84462 90320025
Deep vein thrombosis 63.23 9.86 80 223880 91540 90312947
Neoplasm progression 63.12 9.86 16 223944 44470 90360017
Rectal haemorrhage 62.76 9.86 67 223893 82677 90321810
Cataract 62.16 9.86 52 223908 72040 90332447
Foot deformity 62.11 9.86 35 223925 59616 90344871
Cerebellar syndrome 61.57 9.86 61 223899 3811 90400676
Arthropathy 61.13 9.86 594 223366 365648 90038839
Blood creatinine increased 60.61 9.86 98 223862 101288 90303199
Blood pressure fluctuation 60.21 9.86 27 223933 52386 90352101
Normal newborn 59.84 9.86 159 223801 23203 90381284
Pulmonary fibrosis 59.61 9.86 109 223851 107394 90297093
Inappropriate affect 59.44 9.86 35 223925 990 90403497
Affective disorder 58.99 9.86 84 223876 7709 90396778
Hallucination, visual 58.98 9.86 157 223803 22935 90381552
Metastases to liver 58.70 9.86 3 223957 28804 90375683
Abdominal pain 58.64 9.86 660 223300 395061 90009426
Hypertonia 58.64 9.86 68 223892 5087 90399400
Cheilitis 58.55 9.86 67 223893 4940 90399547
Temporal lobe epilepsy 58.49 9.86 26 223934 399 90404088
Renal failure 58.41 9.86 150 223810 130857 90273630
Pleural effusion 58.22 9.86 118 223842 111873 90292614
Eyelid erosion 58.03 9.86 15 223945 32 90404455
Lactic acidosis 57.96 9.86 26 223934 50437 90354050
Sciatica 57.83 9.86 101 223859 101281 90303206
Cytokine release syndrome 56.72 9.86 3 223957 27970 90376517
Patent ductus arteriosus 56.60 9.86 63 223897 4506 90399981
Thinking abnormal 56.58 9.86 103 223857 11629 90392858
Colitis ulcerative 56.37 9.86 40 223920 60226 90344261
Gestational diabetes 56.31 9.86 97 223863 10485 90394002
Osteoporosis 56.13 9.86 95 223865 96436 90308051
Euphoric mood 55.99 9.86 68 223892 5341 90399146
Femur fracture 55.73 9.86 22 223938 46060 90358427
Dysmorphism 55.47 9.86 48 223912 2520 90401967
Mental disorder 55.43 9.86 191 223769 32127 90372360
Drug resistance 54.91 9.86 183 223777 30266 90374221
Bezoar 54.85 9.86 49 223911 2685 90401802
Heart rate decreased 54.84 9.86 32 223928 53473 90351014
Agitation neonatal 54.79 9.86 27 223933 529 90403958
Treatment noncompliance 54.62 9.86 263 223697 51464 90353023
Pulmonary embolism 54.40 9.86 155 223805 130665 90273822
Cyanosis neonatal 54.31 9.86 25 223935 418 90404069
Dystonia 54.22 9.86 125 223835 16694 90387793
Therapeutic response unexpected 54.11 9.86 147 223813 21733 90382754
Oculomucocutaneous syndrome 54.06 9.86 19 223941 149 90404338
Cystitis 54.06 9.86 51 223909 66667 90337820
Contraindicated product administered 53.51 9.86 519 223441 319620 90084867
Brugada syndrome 52.64 9.86 25 223935 450 90404037
Foetal anticonvulsant syndrome 52.57 9.86 28 223932 649 90403838
Melaena 52.38 9.86 11 223949 34786 90369701
Platelet count decreased 52.16 9.86 169 223791 136800 90267687
Premature baby 51.87 9.86 158 223802 24919 90379568
Psoriasis 51.74 9.86 189 223771 147565 90256922
Pregnancy on oral contraceptive 51.70 9.86 33 223927 1082 90403405
Musculoskeletal stiffness 51.57 9.86 476 223484 296056 90108431
Paradoxical drug reaction 50.97 9.86 67 223893 5699 90398788
Myelosuppression 50.88 9.86 35 223925 53556 90350931
White blood cell count decreased 50.80 9.86 226 223734 166883 90237604
Congenital choroid plexus cyst 50.74 9.86 22 223938 317 90404170
Parkinsonism 50.35 9.86 109 223851 13956 90390531
Muscle twitching 49.60 9.86 152 223808 24050 90380437
Impulsive behaviour 49.30 9.86 38 223922 1692 90402795
Depressive symptom 49.20 9.86 63 223897 5222 90399265
Libido increased 49.03 9.86 38 223922 1706 90402781
Withdrawal syndrome 48.56 9.86 144 223816 22380 90382107
Skin ulcer 48.48 9.86 32 223928 50043 90354444
Osteonecrosis of jaw 48.40 9.86 18 223942 39085 90365402
Hypocalcaemia 48.39 9.86 22 223938 42346 90362141
Loss of consciousness 48.39 9.86 545 223415 139693 90264794
Hostility 48.12 9.86 42 223918 2231 90402256
Simple partial seizures 47.69 9.86 27 223933 708 90403779
Full blood count decreased 47.65 9.86 8 223952 29681 90374806
Heart rate increased 47.51 9.86 133 223827 112769 90291718
Intellectual disability 47.41 9.86 33 223927 1253 90403234
Road traffic accident 47.39 9.86 124 223836 107502 90296985
Dry mouth 47.21 9.86 677 223283 183382 90221105
Protothecosis 46.79 9.86 23 223937 448 90404039
Mucosal inflammation 46.75 9.86 44 223916 57581 90346906
Therapeutic response changed 46.70 9.86 33 223927 1284 90403203
Rash papular 46.64 9.86 133 223827 20222 90384265
Interstitial lung disease 46.47 9.86 73 223887 76332 90328155
Overlap syndrome 46.34 9.86 79 223881 8469 90396018
Anticonvulsant drug level below therapeutic 46.33 9.86 26 223934 670 90403817
Swelling 46.08 9.86 743 223217 418315 89986172
Tic 45.97 9.86 38 223922 1873 90402614
Apathy 45.91 9.86 91 223869 10949 90393538
Pseudolymphoma 45.59 9.86 25 223935 615 90403872
Ascites 45.56 9.86 31 223929 47709 90356778
Thrombocytopenia 45.55 9.86 315 223645 208410 90196077
Basal cell carcinoma 45.50 9.86 13 223947 33376 90371111
Catatonia 45.43 9.86 65 223895 5991 90398496
Decreased appetite 45.36 9.86 656 223304 375884 90028603
Haemoptysis 45.35 9.86 13 223947 33307 90371180
Pulmonary oedema 45.18 9.86 52 223908 62028 90342459
Rash macular 45.18 9.86 171 223789 30109 90374378
Night sweats 45.14 9.86 502 223458 128264 90276223
Skin degenerative disorder 45.05 9.86 9 223951 0 90404487
Sinus congestion 44.89 9.86 7 223953 27417 90377070
Restlessness 44.72 9.86 191 223769 35529 90368958
Inflammation 44.66 9.86 654 223306 177938 90226549
Unintended pregnancy 44.63 9.86 73 223887 7564 90396923
Psychotic symptom 44.40 9.86 40 223920 2216 90402271
Drug clearance increased 44.17 9.86 18 223942 220 90404267
Rhinorrhoea 43.44 9.86 96 223864 88220 90316267
Logorrhoea 43.43 9.86 43 223917 2684 90401803
Pregnancy with implant contraceptive 43.43 9.86 50 223910 3711 90400776
Cerebral microhaemorrhage 43.24 9.86 18 223942 233 90404254
Antipsychotic drug level increased 43.24 9.86 50 223910 3729 90400758
Conjunctival abrasion 43.03 9.86 11 223949 22 90404465
Hypomagnesaemia 43.02 9.86 17 223943 35571 90368916
Metastases to bone 42.92 9.86 6 223954 25499 90378988
Immunodeficiency 42.72 9.86 27 223933 43207 90361280
Myalgia 42.43 9.86 256 223704 174869 90229618
Coronary artery disease 42.42 9.86 15 223945 33608 90370879
Throat irritation 42.13 9.86 35 223925 48660 90355827
Septic shock 41.79 9.86 91 223869 84069 90320418
Seizure cluster 41.67 9.86 20 223940 369 90404118
Type 2 diabetes mellitus 41.67 9.86 720 223240 202524 90201963
Cerebral salt-wasting syndrome 41.20 9.86 17 223943 215 90404272
Lip ulceration 41.15 9.86 38 223922 2174 90402313
Coarctation of the aorta 40.70 9.86 23 223937 601 90403886
Spina bifida 40.69 9.86 26 223934 854 90403633
Speech disorder 40.60 9.86 221 223739 45364 90359123
Underdose 40.38 9.86 250 223710 53767 90350720
Respiratory tract infection 40.33 9.86 52 223908 59026 90345461
Coma scale abnormal 40.19 9.86 59 223901 5567 90398920
Lung neoplasm malignant 40.18 9.86 6 223954 24267 90380220
Injection site bruising 40.06 9.86 42 223918 52265 90352222
Disorientation 40.06 9.86 215 223745 43899 90360588
Pulmonary arterial hypertension 40.00 9.86 8 223952 26179 90378308
Hypotonia neonatal 39.86 9.86 31 223929 1399 90403088
Palpitations 39.72 9.86 188 223772 136540 90267947
Loss of personal independence in daily activities 39.62 9.86 187 223773 135918 90268569
Hypoxia 39.61 9.86 74 223886 72325 90332162
Acute myeloid leukaemia 39.51 9.86 3 223957 20637 90383850
Persecutory delusion 39.34 9.86 44 223916 3164 90401323
Blood pressure diastolic decreased 39.33 9.86 9 223951 26817 90377670
Injection site pruritus 39.27 9.86 45 223915 53789 90350698
Mucosal disorder 39.23 9.86 41 223919 2730 90401757
Change in seizure presentation 39.10 9.86 22 223938 570 90403917
Hypokalaemia 38.84 9.86 179 223781 130937 90273550
Pulmonary hypertension 38.76 9.86 29 223931 42494 90361993
Concussion 38.62 9.86 85 223875 11006 90393481
Drug withdrawal convulsions 38.55 9.86 31 223929 1469 90403018
Balance disorder 38.49 9.86 388 223572 96692 90307795
Hepatotoxicity 38.38 9.86 34 223926 45808 90358679
Product use in unapproved indication 38.28 9.86 1095 222865 335141 90069346
Anti-cyclic citrullinated peptide antibody 38.22 9.86 10 223950 27211 90377276
Low set ears 38.06 9.86 17 223943 264 90404223
Palmar-plantar erythrodysaesthesia syndrome 38.02 9.86 11 223949 28012 90376475
Bone pain 37.90 9.86 59 223901 61924 90342563
Ischaemic stroke 37.81 9.86 5 223955 22161 90382326
Red blood cell sedimentation rate abnormal 37.80 9.86 7 223953 24197 90380290
Dysphonia 37.68 9.86 61 223899 63023 90341464
Retrognathia 37.36 9.86 21 223939 543 90403944
Upper gastrointestinal haemorrhage 37.30 9.86 6 223954 22970 90381517
Vulvar erosion 37.28 9.86 15 223945 177 90404310
Haemorrhoids 37.12 9.86 10 223950 26692 90377795
Developmental hip dysplasia 37.05 9.86 31 223929 1554 90402933
Flat affect 37.00 9.86 32 223928 1679 90402808
Exposure via ingestion 36.93 9.86 39 223921 2628 90401859
Human herpesvirus 6 infection 36.92 9.86 44 223916 3388 90401099
Mucosal erosion 36.88 9.86 33 223927 1812 90402675
Maternal exposure before pregnancy 36.88 9.86 84 223876 11129 90393358
Oral disorder 36.84 9.86 80 223880 10265 90394222
Anaphylactic shock 36.77 9.86 16 223944 31601 90372886
Hepatic enzyme 36.68 9.86 55 223905 5289 90399198
Lymphocyte morphology abnormal 36.51 9.86 20 223940 491 90403996
Rhabdomyolysis 36.32 9.86 234 223726 51022 90353465
Psychiatric symptom 36.25 9.86 64 223896 7054 90397433
Congenital anomaly 36.19 9.86 60 223900 6287 90398200
Right ventricular failure 36.18 9.86 3 223957 19202 90385285
Dry skin 36.14 9.86 105 223855 87968 90316519
Epidermolysis bullosa 35.98 9.86 15 223945 195 90404292
Localised infection 35.95 9.86 19 223941 33543 90370944
Obsessive thoughts 35.89 9.86 21 223939 587 90403900
Hypotonia 35.82 9.86 84 223876 11342 90393145
Acute myocardial infarction 35.57 9.86 21 223939 34869 90369618
Creatinine renal clearance decreased 35.47 9.86 3 223957 18896 90385591
Angina pectoris 35.32 9.86 27 223933 39133 90365354
Accidental exposure to product by child 35.22 9.86 28 223932 1305 90403182
Giant cell myocarditis 35.21 9.86 9 223951 18 90404469
Hallucination 35.07 9.86 281 223679 65678 90338809
Inappropriate schedule of product administration 34.85 9.86 222 223738 149711 90254776
Central nervous system lesion 34.76 9.86 84 223876 11562 90392925
Encephalopathy 34.75 9.86 215 223745 46229 90358258
Traumatic coma 34.55 9.86 11 223949 61 90404426
Microcephaly 34.29 9.86 28 223932 1356 90403131
Hypocholesterolaemia 34.17 9.86 59 223901 6390 90398097
Osteomyelitis 34.16 9.86 13 223947 27833 90376654
Autism spectrum disorder 33.82 9.86 27 223933 1266 90403221
Sleep disorder 33.82 9.86 682 223278 197348 90207139
Pregnancy on contraceptive 33.78 9.86 27 223933 1268 90403219
Bronchiectasis 33.73 9.86 7 223953 22323 90382164
Polyhydramnios 33.54 9.86 36 223924 2472 90402015
Vestibular migraine 33.35 9.86 15 223945 237 90404250
Soft tissue injury 33.34 9.86 33 223927 2059 90402428
Cytomegalovirus infection 33.34 9.86 12 223948 26590 90377897
Cerebral infarction 33.32 9.86 12 223948 26584 90377903
Eye movement disorder 33.23 9.86 57 223903 6141 90398346
Inappropriate antidiuretic hormone secretion 33.21 9.86 115 223845 19390 90385097
Paranoia 33.21 9.86 88 223872 12820 90391667
Salivary hypersecretion 33.17 9.86 71 223889 9021 90395466
Ureteric perforation 33.15 9.86 8 223952 11 90404476
Hydrops foetalis 33.12 9.86 20 223940 593 90403894
Benzodiazepine drug level increased 33.11 9.86 14 223946 189 90404298
Respiratory depression 33.03 9.86 99 223861 15476 90389011
Stereotypy 33.00 9.86 18 223942 438 90404049
Hypervolaemia 33.00 9.86 20 223940 32737 90371750
Dysarthria 32.82 9.86 239 223721 54243 90350244
Pulmonary mass 32.77 9.86 15 223945 28757 90375730
Eosinophil percentage increased 32.73 9.86 24 223936 990 90403497
Self-injurious ideation 32.72 9.86 40 223920 3163 90401324
Ejection fraction decreased 32.63 9.86 12 223948 26241 90378246
Anaphylactic reaction 32.62 9.86 109 223851 87415 90317072
Angiofibroma 32.61 9.86 12 223948 109 90404378
Accessory auricle 32.55 9.86 7 223953 3 90404484
Gambling disorder 32.44 9.86 26 223934 1226 90403261
Abnormal palmar/plantar creases 32.43 9.86 10 223950 49 90404438
Chronic kidney disease 32.42 9.86 46 223914 50145 90354342
Vanishing bile duct syndrome 32.41 9.86 27 223933 1345 90403142
Metastases to central nervous system 32.34 9.86 3 223957 17539 90386948
Cardiac disorder 32.12 9.86 57 223903 56815 90347672
Paraesthesia 32.10 9.86 828 223132 249498 90154989
Crying 32.00 9.86 137 223823 25508 90378979
Drug screen false positive 31.99 9.86 23 223937 920 90403567
Nightmare 31.84 9.86 122 223838 21603 90382884
Gastric ulcer 31.75 9.86 14 223946 27434 90377053
Epistaxis 31.73 9.86 106 223854 85019 90319468
Joint range of motion decreased 31.68 9.86 491 223469 135152 90269335
Photophobia 31.64 9.86 120 223840 21149 90383338
Haematuria 31.62 9.86 24 223936 34913 90369574
Lower limb fracture 31.60 9.86 106 223854 84907 90319580
Injection site swelling 31.14 9.86 63 223897 59776 90344711
Learning disorder 31.13 9.86 22 223938 856 90403631
Product dose omission issue 31.10 9.86 520 223440 291167 90113320
Sternal fracture 31.04 9.86 37 223923 2850 90401637
Muscle spasticity 31.04 9.86 25 223935 35297 90369190
Ear infection 31.01 9.86 80 223880 69695 90334792
Papule 30.95 9.86 64 223896 7938 90396549
Product dispensing error 30.89 9.86 83 223877 12190 90392297
SJS-TEN overlap 30.84 9.86 24 223936 1084 90403403
Blood glucose increased 30.66 9.86 126 223834 95120 90309367
Pregnancy 30.66 9.86 260 223700 61787 90342700
Joint stiffness 30.61 9.86 95 223865 77947 90326540
Female genital tract fistula 30.55 9.86 4 223956 17864 90386623
Galactorrhoea 30.53 9.86 47 223913 4625 90399862
Neonatal respiratory distress syndrome 30.51 9.86 38 223922 3063 90401424
Autoimmune disorder 30.40 9.86 93 223867 76651 90327836
Intermenstrual bleeding 30.23 9.86 69 223891 9154 90395333
Disseminated intravascular coagulation 29.98 9.86 119 223841 21419 90383068
Human herpesvirus 6 infection reactivation 29.98 9.86 19 223941 615 90403872
Corneal reflex decreased 29.89 9.86 15 223945 306 90404181
Neoplasm malignant 29.75 9.86 24 223936 33856 90370631
Blood pressure systolic abnormal 29.64 9.86 6 223954 19472 90385015
Distractibility 29.59 9.86 18 223942 541 90403946
Spinal stenosis 29.56 9.86 4 223956 17420 90387067
Major depression 29.55 9.86 72 223888 9963 90394524
Body temperature decreased 29.41 9.86 11 223949 23805 90380682
Chronic sinusitis 29.38 9.86 11 223949 23791 90380696
Bone density decreased 29.38 9.86 4 223956 17341 90387146
Exomphalos 29.30 9.86 18 223942 551 90403936
Bradypnoea 29.24 9.86 46 223914 4612 90399875
Postictal psychosis 29.23 9.86 11 223949 107 90404380
Tubulointerstitial nephritis and uveitis syndrome 29.18 9.86 14 223946 258 90404229
Hypercalcaemia 29.14 9.86 25 223935 34215 90370272
Congenital skin dimples 29.13 9.86 11 223949 108 90404379
Adrenal insufficiency 29.13 9.86 19 223941 29902 90374585
Distributive shock 29.06 9.86 39 223921 3385 90401102
Impulse-control disorder 28.93 9.86 22 223938 960 90403527
Gastrointestinal disorder 28.89 9.86 453 223507 256234 90148253
Oxygen saturation decreased 28.80 9.86 152 223808 107331 90297156
Nodule 28.74 9.86 15 223945 26671 90377816
Myelodysplastic syndrome 28.74 9.86 8 223952 20895 90383592
Joint dislocation 28.65 9.86 41 223919 44541 90359946
Panic attack 28.52 9.86 135 223825 26230 90378257
Device related infection 28.51 9.86 14 223946 25772 90378715
Multiple congenital abnormalities 28.50 9.86 18 223942 579 90403908
Full blood count abnormal 28.46 9.86 29 223931 36568 90367919
Post-traumatic neck syndrome 28.32 9.86 33 223927 2481 90402006
Sinus disorder 28.30 9.86 26 223934 34421 90370066
Injection site reaction 28.28 9.86 350 223610 91730 90312757
Hemivertebra 28.27 9.86 11 223949 118 90404369
Haematemesis 28.25 9.86 25 223935 33701 90370786
Retinogram abnormal 28.11 9.86 12 223948 166 90404321
Negative symptoms in schizophrenia 28.11 9.86 11 223949 120 90404367
Illusion 28.06 9.86 24 223936 1240 90403247
Poor sucking reflex 27.94 9.86 16 223944 429 90404058
Drug tolerance decreased 27.91 9.86 23 223937 32107 90372380
Arnold-Chiari malformation 27.82 9.86 19 223941 699 90403788
Grip strength decreased 27.63 9.86 350 223610 92226 90312261
Drug intolerance 27.57 9.86 869 223091 446722 89957765
Spinal fracture 27.47 9.86 10 223950 22006 90382481
Rheumatoid arthritis 27.45 9.86 684 223276 361930 90042557
Blister 27.24 9.86 824 223136 254174 90150313
Thyroiditis 27.23 9.86 39 223921 3598 90400889
Attention deficit hyperactivity disorder 27.21 9.86 42 223918 4142 90400345
Anorectal malformation 27.17 9.86 13 223947 238 90404249
Pharyngeal erythema 27.17 9.86 28 223932 1834 90402653
Product use issue 27.00 9.86 615 223345 329304 90075183
Nephrogenic diabetes insipidus 26.97 9.86 21 223939 949 90403538
Hyperbilirubinaemia neonatal 26.92 9.86 15 223945 381 90404106
Placental disorder 26.77 9.86 26 223934 1585 90402902
Hyperprolactinaemia 26.58 9.86 48 223912 5385 90399102
Resting tremor 26.49 9.86 20 223940 863 90403624
Premature labour 26.48 9.86 83 223877 13293 90391194
Procedural pain 26.44 9.86 26 223934 33334 90371153
Haematocrit decreased 26.37 9.86 39 223921 41793 90362694
Orthostatic hypertension 26.35 9.86 17 223943 568 90403919
Hypoglycaemia neonatal 26.34 9.86 22 223938 1100 90403387
Peritonitis 26.25 9.86 8 223952 19697 90384790
Hyperglycaemia 26.23 9.86 54 223906 50916 90353571
Hiatus hernia 26.23 9.86 15 223945 25346 90379141
Headache 26.21 9.86 1808 222152 860938 89543549
Gastroschisis 26.17 9.86 15 223945 403 90404084
Pneumonitis 26.11 9.86 43 223917 44127 90360360
Persistent genital arousal disorder 25.89 9.86 18 223942 682 90403805
Cholelithiasis 25.88 9.86 57 223903 52449 90352038
Feeling drunk 25.83 9.86 44 223916 4714 90399773
Lymphangioleiomyomatosis 25.65 9.86 13 223947 271 90404216
Wrong patient received product 25.62 9.86 37 223923 3440 90401047
Radiculopathy 25.60 9.86 7 223953 18498 90385989
Tonsillar hypertrophy 25.51 9.86 22 223938 1150 90403337
Transfusion 25.37 9.86 6 223954 17482 90387005
Oesophageal atresia 25.20 9.86 17 223943 613 90403874
Pre-eclampsia 25.13 9.86 72 223888 10976 90393511
Pneumocystis jirovecii pneumonia 25.04 9.86 11 223949 21605 90382882
Pancytopenia 25.00 9.86 184 223776 120079 90284408
Skin erosion 24.93 9.86 36 223924 3346 90401141
Poor feeding infant 24.87 9.86 16 223944 532 90403955
Conjunctivitis 24.82 9.86 131 223829 26575 90377912
Red blood cell count decreased 24.80 9.86 48 223912 46303 90358184
Syncope 24.78 9.86 209 223751 132454 90272033
Dysphoria 24.72 9.86 50 223910 6104 90398383
Neutrophil count decreased 24.70 9.86 92 223868 71440 90333047
Transient ischaemic attack 24.63 9.86 43 223917 43133 90361354
Rapid eye movement sleep behaviour disorder 24.60 9.86 14 223946 371 90404116
Sinus tachycardia 24.57 9.86 137 223823 28376 90376111
Blood calcium decreased 24.53 9.86 23 223937 30159 90374328
Flushing 24.35 9.86 124 223836 88367 90316120
Poor weight gain neonatal 24.15 9.86 9 223951 85 90404402
Gout 24.04 9.86 6 223954 16853 90387634
Fungal infection 23.87 9.86 43 223917 42618 90361869
Blood test abnormal 23.74 9.86 11 223949 20941 90383546
Flank pain 23.53 9.86 9 223951 19213 90385274
Disorganised speech 23.37 9.86 26 223934 1859 90402628
Clostridium difficile colitis 23.34 9.86 19 223941 26687 90377800
Respiratory tract congestion 23.34 9.86 20 223940 27390 90377097
Drooling 23.32 9.86 41 223919 4505 90399982
Anomalous pulmonary venous connection 23.31 9.86 8 223952 58 90404429
Psychomotor skills impaired 23.29 9.86 32 223928 2840 90401647
Musculoskeletal chest pain 23.23 9.86 15 223945 23735 90380752
Congenital anomaly in offspring 22.76 9.86 10 223950 149 90404338
Bradycardia neonatal 22.74 9.86 20 223940 1073 90403414
Tachycardia 22.74 9.86 530 223430 157143 90247344
Chloropsia 22.73 9.86 8 223952 63 90404424
Gaze palsy 22.73 9.86 24 223936 1617 90402870
Deep vein thrombosis postoperative 22.59 9.86 94 223866 70715 90333772
Persistent left superior vena cava 22.58 9.86 7 223953 35 90404452
Limb discomfort 22.54 9.86 37 223923 38023 90366464
Vomiting projectile 22.51 9.86 25 223935 1784 90402703
Food allergy 22.43 9.86 18 223942 25460 90379027
Oral herpes 22.38 9.86 30 223930 33494 90370993
Bile acid malabsorption 22.34 9.86 12 223948 283 90404204
Musculoskeletal disorder 22.34 9.86 13 223947 21756 90382731
Pyloric stenosis 22.29 9.86 14 223946 446 90404041
Metastases to lung 22.21 9.86 6 223954 15985 90388502
Sleep-related eating disorder 22.16 9.86 19 223941 985 90403502
Entropion 22.16 9.86 9 223951 109 90404378
Lymphadenitis 22.12 9.86 38 223922 4099 90400388
Flatulence 22.00 9.86 43 223917 41324 90363163
Tachyphrenia 21.96 9.86 24 223936 1682 90402805
Self-medication 21.90 9.86 33 223927 3187 90401300
Infantile apnoea 21.82 9.86 21 223939 1266 90403221
Metabolic syndrome 21.70 9.86 25 223935 1857 90402630
Thrombotic microangiopathy 21.69 9.86 6 223954 15737 90388750
Clostridium difficile infection 21.69 9.86 35 223925 36210 90368277
Gastritis 21.69 9.86 44 223916 41709 90362778
Volvulus 21.68 9.86 27 223933 2176 90402311
Posture abnormal 21.68 9.86 30 223930 2681 90401806
Hypersomnia 21.67 9.86 108 223852 21423 90383064
Cerebral atrophy 21.65 9.86 45 223915 5601 90398886
Dysphemia 21.65 9.86 32 223928 3038 90401449
Pupillary reflex impaired 21.62 9.86 29 223931 2516 90401971
Weight gain poor 21.54 9.86 20 223940 1152 90403335
Lymphocyte stimulation test positive 21.45 9.86 14 223946 477 90404010
Lipids abnormal 21.43 9.86 12 223948 308 90404179
Injection site haemorrhage 21.39 9.86 23 223937 28295 90376192
Ulcer 21.37 9.86 30 223930 32852 90371635
Joint effusion 21.34 9.86 11 223949 19699 90384788
Postmortem blood drug level abnormal 21.21 9.86 11 223949 241 90404246
Coprolalia 21.06 9.86 6 223954 21 90404466
Tuberculosis 21.01 9.86 3 223957 12546 90391941
Orthostatic hypotension 20.95 9.86 45 223915 41782 90362705
Congenital hand malformation 20.91 9.86 12 223948 323 90404164
Cardiac malposition 20.85 9.86 7 223953 47 90404440
Miosis 20.79 9.86 61 223899 9423 90395064
Arterial occlusive disease 20.78 9.86 3 223957 12443 90392044
Angioedema 20.77 9.86 86 223874 64790 90339697
Lung disorder 20.76 9.86 501 223459 149382 90255105
Automatism 20.71 9.86 8 223952 84 90404403
Abortion missed 20.65 9.86 25 223935 1957 90402530
Staring 20.64 9.86 23 223937 1647 90402840
Walking aid user 20.58 9.86 35 223925 35471 90369016
Therapeutic product effect incomplete 20.55 9.86 626 223334 193270 90211217
Spinal compression fracture 20.51 9.86 6 223954 15172 90389315
Irregular sleep phase 20.44 9.86 6 223954 24 90404463
Postictal state 20.42 9.86 21 223939 1372 90403115
Breast cancer metastatic 20.42 9.86 6 223954 15126 90389361
Dissociative disorder 20.41 9.86 15 223945 621 90403866
Oscillopsia 20.37 9.86 9 223951 136 90404351
Persistent depressive disorder 20.35 9.86 20 223940 1237 90403250
Heart rate irregular 20.31 9.86 18 223942 24250 90380237
Developmental delay 20.31 9.86 23 223937 1677 90402810
Brain death 20.28 9.86 36 223924 3985 90400502
Illness 20.28 9.86 119 223841 81850 90322637
Spinal osteoarthritis 20.27 9.86 11 223949 19137 90385350
Hereditary ataxia 20.24 9.86 6 223954 25 90404462
Mediastinitis 20.21 9.86 12 223948 345 90404142
Intention tremor 20.10 9.86 13 223947 436 90404051
Oral hairy leukoplakia 20.02 9.86 4 223956 0 90404487
Seronegative arthritis 20.01 9.86 10 223950 18224 90386263
Blood lactate dehydrogenase increased 20.00 9.86 121 223839 25811 90378676
Impatience 19.95 9.86 13 223947 442 90404045
Drug level changed 19.93 9.86 10 223950 204 90404283
Breast cancer female 19.91 9.86 6 223954 14880 90389607
Electrocardiogram ST segment depression 19.88 9.86 32 223928 3271 90401216
Therapy non-responder 19.81 9.86 229 223731 136475 90268012
Sputum discoloured 19.78 9.86 13 223947 20378 90384109
Combined immunodeficiency 19.74 9.86 9 223951 147 90404340
Acute respiratory distress syndrome 19.73 9.86 130 223830 28556 90375931
Abnormal dreams 19.72 9.86 67 223893 11190 90393297
Vascular device infection 19.68 9.86 3 223957 11949 90392538
Body height decreased 19.67 9.86 3 223957 11946 90392541
Gastroenteritis 19.67 9.86 26 223934 29203 90375284
Drug withdrawal syndrome 19.66 9.86 130 223830 28593 90375894
Oesophagitis 19.63 9.86 9 223951 17240 90387247
Clumsiness 19.58 9.86 28 223932 2579 90401908
Flight of ideas 19.56 9.86 13 223947 457 90404030
Borderline personality disorder 19.37 9.86 18 223942 1038 90403449
Coordination abnormal 19.33 9.86 104 223856 21252 90383235
Breast cancer 19.32 9.86 68 223892 53693 90350794
Epstein-Barr virus infection reactivation 19.30 9.86 22 223938 1615 90402872
Hepatosplenomegaly 19.28 9.86 30 223930 2979 90401508
Temperature regulation disorder 19.27 9.86 6 223954 14573 90389914
Gamma-glutamyltransferase increased 19.26 9.86 160 223800 37792 90366695
Hereditary optic atrophy 19.20 9.86 6 223954 31 90404456
Dry eye 19.04 9.86 76 223884 57855 90346632
Symblepharon 18.98 9.86 11 223949 302 90404185
Tendonitis 18.94 9.86 15 223945 21357 90383130
Acquired immunodeficiency syndrome 18.92 9.86 8 223952 108 90404379
Skin cancer 18.91 9.86 5 223955 13514 90390973
Cataplexy 18.90 9.86 21 223939 1499 90402988
Illogical thinking 18.88 9.86 7 223953 65 90404422
Alopecia universalis 18.80 9.86 9 223951 165 90404322
Haematotoxicity 18.79 9.86 4 223956 12531 90391956
Postmortem blood drug level 18.72 9.86 8 223952 111 90404376
Liver injury 18.70 9.86 553 223407 170014 90234473
Epidermal necrosis 18.69 9.86 26 223934 2335 90402152
Substance use disorder 18.68 9.86 24 223936 1996 90402491
Gait inability 18.63 9.86 484 223476 145972 90258515
Tricuspid valve incompetence 18.63 9.86 9 223951 16722 90387765
Hyperammonaemia 18.58 9.86 46 223914 6429 90398058
Oral mucosal eruption 18.52 9.86 16 223944 838 90403649
Mitral valve incompetence 18.50 9.86 17 223943 22507 90381980
Herpangina 18.45 9.86 6 223954 36 90404451
Injury corneal 18.37 9.86 9 223951 174 90404313
Anuria 18.37 9.86 79 223881 14739 90389748
Gastric disorder 18.37 9.86 34 223926 33350 90371137
Limb reduction defect 18.35 9.86 14 223946 614 90403873
External auditory canal atresia 18.34 9.86 7 223953 71 90404416
Staphylococcal infection 18.27 9.86 60 223900 48379 90356108
Cholestasis of pregnancy 18.27 9.86 21 223939 1556 90402931
Lymphocytic infiltration 18.26 9.86 18 223942 1118 90403369
Angiomyolipoma 18.24 9.86 10 223950 246 90404241
Poor venous access 18.21 9.86 13 223947 19514 90384973
Screaming 18.18 9.86 33 223927 3717 90400770
Lip scab 18.13 9.86 5 223955 15 90404472
Tooth infection 18.07 9.86 14 223946 20156 90384331
Blood iron decreased 18.04 9.86 11 223949 17948 90386539
Chills 18.01 9.86 224 223736 131757 90272730
Toothache 18.00 9.86 17 223943 22213 90382274
Synovitis 18.00 9.86 650 223310 329102 90075385
Plagiocephaly 17.98 9.86 8 223952 123 90404364
Lipids 17.89 9.86 5 223955 16 90404471
Injection site rash 17.86 9.86 20 223940 24153 90380334
Blood potassium increased 17.84 9.86 15 223945 20734 90383753
Pregnancy with contraceptive device 17.84 9.86 39 223921 5027 90399460
Manic symptom 17.84 9.86 7 223953 77 90404410
Sleep paralysis 17.83 9.86 16 223944 882 90403605
Strabismus 17.80 9.86 26 223934 2442 90402045
Congenital anaemia 17.79 9.86 4 223956 3 90404484
Iris coloboma 17.78 9.86 6 223954 41 90404446
Electrocardiogram QT shortened 17.74 9.86 9 223951 188 90404299
Laryngeal ulceration 17.66 9.86 5 223955 17 90404470
Derealisation 17.58 9.86 20 223940 1465 90403022
Therapeutic product effective for unapproved indication 17.58 9.86 8 223952 130 90404357
Breath sounds abnormal 17.55 9.86 8 223952 15378 90389109
Hypoglycaemia 17.49 9.86 101 223859 69747 90334740
Colon cancer 17.45 9.86 3 223957 10941 90393546
Brachycephaly 17.44 9.86 5 223955 18 90404469
Deja vu 17.36 9.86 8 223952 134 90404353
Hypoaesthesia 17.35 9.86 946 223014 313264 90091223
Genital erosion 17.35 9.86 12 223948 451 90404036
Red blood cell sedimentation rate increased 17.34 9.86 126 223834 82469 90322018
Tension 17.34 9.86 32 223928 3650 90400837
Frequent bowel movements 17.29 9.86 77 223883 56858 90347629
Cerebellar atrophy 17.26 9.86 15 223945 792 90403695
Rhinitis allergic 17.26 9.86 10 223950 16775 90387712
Lymphoma 17.25 9.86 6 223954 13585 90390902
Educational problem 17.24 9.86 13 223947 560 90403927
Retinal pigment epitheliopathy 17.24 9.86 10 223950 275 90404212
Drop attacks 17.11 9.86 14 223946 680 90403807
Coma scale 17.08 9.86 6 223954 47 90404440
Oral candidiasis 17.06 9.86 39 223921 35416 90369071
Drug ineffective for unapproved indication 17.02 9.86 245 223715 66399 90338088
Photosensitivity reaction 17.00 9.86 88 223872 17719 90386768
Purpura 16.96 9.86 77 223883 14701 90389786
Postoperative wound infection 16.92 9.86 6 223954 13420 90391067
International normalised ratio increased 16.90 9.86 60 223900 47256 90357231
Depression suicidal 16.87 9.86 23 223937 2026 90402461
Pulmonary congestion 16.77 9.86 14 223946 19419 90385068
Spondylitis 16.77 9.86 7 223953 14171 90390316
Antidepressant drug level above therapeutic 16.73 9.86 12 223948 478 90404009
Glaucoma 16.65 9.86 16 223944 20739 90383748
Brain oedema 16.65 9.86 86 223874 17299 90387188
Food interaction 16.65 9.86 18 223942 1246 90403241
Head titubation 16.60 9.86 18 223942 1250 90403237
Dermatitis exfoliative 16.60 9.86 40 223920 5496 90398991
Cerebral haemorrhage 16.58 9.86 38 223922 34484 90370003
Osteoarthritis 16.44 9.86 615 223345 195115 90209372
Conjunctival disorder 16.40 9.86 10 223950 302 90404185
Carpal tunnel syndrome 16.39 9.86 21 223939 23907 90380580
Emotional poverty 16.39 9.86 11 223949 393 90404094
Pleuritic pain 16.39 9.86 3 223957 10458 90394029
Parachute mitral valve 16.39 9.86 7 223953 97 90404390
Blood prolactin increased 16.37 9.86 31 223929 3606 90400881
Ankylosing spondylitis 16.33 9.86 6 223954 13127 90391360
Hippocampal sclerosis 16.33 9.86 7 223953 98 90404389
Device issue 16.32 9.86 30 223930 29507 90374980
Product packaging confusion 16.32 9.86 9 223951 224 90404263
Vision blurred 16.29 9.86 372 223588 109921 90294566
Hepatocellular injury 16.29 9.86 125 223835 28833 90375654
Homicidal ideation 16.23 9.86 21 223939 1759 90402728
Gestational hypertension 16.20 9.86 28 223932 3034 90401453
Bone disorder 16.14 9.86 20 223940 23100 90381387
Exposure via transplant 16.13 9.86 5 223955 25 90404462
Choroidal coloboma 16.13 9.86 5 223955 25 90404462
Presyncope 16.11 9.86 34 223926 31771 90372716
Weight fluctuation 16.11 9.86 15 223945 19734 90384753
Polyarthritis 16.11 9.86 13 223947 18337 90386150
Rash erythematous 16.10 9.86 238 223722 64866 90339621
Erythema of eyelid 16.06 9.86 29 223931 3254 90401233
Hallucinations, mixed 16.02 9.86 41 223919 5848 90398639
Meningomyelocele 15.93 9.86 13 223947 629 90403858
Adjustment disorder with depressed mood 15.91 9.86 79 223881 56674 90347813
Drug level fluctuating 15.91 9.86 12 223948 517 90403970
Blood calcium increased 15.87 9.86 5 223955 12053 90392434
Cytopenia 15.77 9.86 12 223948 17437 90387050
Cerebral ventricle dilatation 15.75 9.86 16 223944 1030 90403457
Liver disorder 15.74 9.86 208 223752 121061 90283426
Oral mucosal blistering 15.63 9.86 45 223915 6879 90397608
Cerebellar ataxia 15.55 9.86 15 223945 907 90403580
Bipolar II disorder 15.54 9.86 11 223949 429 90404058
Gait deviation 15.54 9.86 6 223954 63 90404424
Congenital aortic valve stenosis 15.54 9.86 6 223954 63 90404424
Disinhibition 15.47 9.86 16 223944 1052 90403435
Haemorrhage 15.46 9.86 104 223856 69265 90335222
Blood potassium decreased 15.44 9.86 63 223897 47664 90356823
Spinal pain 15.37 9.86 10 223950 15757 90388730
Hypertension 15.34 9.86 950 223010 456582 89947905
Blood magnesium decreased 15.23 9.86 10 223950 15683 90388804
Small intestinal obstruction 15.22 9.86 18 223942 21216 90383271
Malignant melanoma 15.21 9.86 6 223954 12570 90391917
Self esteem decreased 15.15 9.86 14 223946 802 90403685
Negativism 15.04 9.86 11 223949 452 90404035
Congenital oesophageal anomaly 15.04 9.86 4 223956 10 90404477
Dysmetria 15.03 9.86 13 223947 682 90403805
Pharyngeal exudate 15.02 9.86 3 223957 0 90404487
Mononucleosis heterophile test positive 15.02 9.86 3 223957 0 90404487
Selective mutism 15.02 9.86 3 223957 0 90404487
Retinal coloboma 14.97 9.86 5 223955 33 90404454
Anorgasmia 14.95 9.86 13 223947 687 90403800
Neuropsychiatric symptoms 14.93 9.86 13 223947 688 90403799
Macule 14.91 9.86 25 223935 2644 90401843
Pancreatitis acute 14.91 9.86 36 223924 32079 90372408
Seasonal allergy 14.91 9.86 21 223939 22962 90381525
Attention-seeking behaviour 14.90 9.86 6 223954 71 90404416
Suicide threat 14.84 9.86 5 223955 34 90404453
Product name confusion 14.84 9.86 7 223953 124 90404363
Product administration error 14.83 9.86 114 223846 26309 90378178
Urinary incontinence 14.82 9.86 150 223810 37416 90367071
Pulmonary toxicity 14.80 9.86 5 223955 11526 90392961
Increased appetite 14.79 9.86 63 223897 11702 90392785
Psychiatric decompensation 14.79 9.86 21 223939 1922 90402565
Basilar artery occlusion 14.77 9.86 8 223952 192 90404295
Learning disability 14.75 9.86 9 223951 272 90404215
Suppressed lactation 14.75 9.86 11 223949 466 90404021
Hospice care 14.75 9.86 3 223957 9701 90394786
Anal erosion 14.72 9.86 5 223955 35 90404452
Left ventricular dysfunction 14.71 9.86 9 223951 14660 90389827
Cardiomegaly 14.71 9.86 15 223945 18910 90385577
Granulocytopenia 14.67 9.86 42 223918 6399 90398088
Hip fracture 14.64 9.86 38 223922 33039 90371448
Adjustment disorder 14.61 9.86 3 223957 9639 90394848
Morose 14.60 9.86 5 223955 36 90404451
Somnambulism 14.57 9.86 41 223919 6187 90398300
Ventricular fibrillation 14.53 9.86 71 223889 13973 90390514
Postictal paralysis 14.52 9.86 9 223951 280 90404207
Hepatic cirrhosis 14.52 9.86 94 223866 63159 90341328
Microencephaly 14.51 9.86 4 223956 12 90404475
Mucocutaneous rash 14.48 9.86 5 223955 37 90404450
Vertebral artery occlusion 14.47 9.86 8 223952 200 90404287
Self-destructive behaviour 14.46 9.86 11 223949 480 90404007
Vasculitis 14.46 9.86 21 223939 22672 90381815
Hypotension 14.41 9.86 657 223303 324740 90079747
Hot flush 14.38 9.86 87 223873 59401 90345086
Cleft palate 14.37 9.86 17 223943 1299 90403188
Renal cyst 14.36 9.86 7 223953 12943 90391544
Acquired epidermolysis bullosa 14.36 9.86 5 223955 38 90404449
Limbic encephalitis 14.35 9.86 9 223951 286 90404201
Acute respiratory failure 14.30 9.86 56 223904 42862 90361625
Paraesthesia oral 14.30 9.86 36 223924 31623 90372864
Diverticulum 14.29 9.86 6 223954 12107 90392380
Product administration interrupted 14.27 9.86 65 223895 12427 90392060
Viral rash 14.27 9.86 10 223950 384 90404103
Retinitis 14.26 9.86 48 223912 38410 90366077
Systemic lupus erythematosus 14.21 9.86 740 223220 361156 90043331
Therapeutic product ineffective for unapproved indication 14.18 9.86 9 223951 292 90404195
Cortical dysplasia 14.14 9.86 5 223955 40 90404447
Mononucleosis syndrome 14.12 9.86 8 223952 210 90404277
Regressive behaviour 14.12 9.86 8 223952 210 90404277
Gastroenteritis viral 14.11 9.86 34 223926 30321 90374166
Lennox-Gastaut syndrome 14.07 9.86 9 223951 296 90404191
Alcohol abuse 14.06 9.86 21 223939 2012 90402475
Frontal lobe epilepsy 14.04 9.86 4 223956 14 90404473
Colitis microscopic 14.04 9.86 5 223955 11154 90393333
Social avoidant behaviour 14.03 9.86 28 223932 3385 90401102
Dysmetropsia 13.99 9.86 6 223954 84 90404403
Blood pressure decreased 13.98 9.86 118 223842 74777 90329710
Drug hypersensitivity 13.95 9.86 972 222988 462637 89941850
Cardiac failure acute 13.93 9.86 6 223954 11923 90392564
Posterior reversible encephalopathy syndrome 13.91 9.86 21 223939 22318 90382169
Areflexia 13.87 9.86 29 223931 3624 90400863
Nephropathy toxic 13.86 9.86 7 223953 12681 90391806
Placental infarction 13.83 9.86 9 223951 305 90404182
Hyperlipidaemia 13.83 9.86 22 223938 22894 90381593
Ulcerative keratitis 13.81 9.86 28 223932 3425 90401062
Wrist fracture 13.80 9.86 11 223949 15613 90388874
Peripheral sensory neuropathy 13.77 9.86 3 223957 9247 90395240
Scab 13.76 9.86 54 223906 9667 90394820
Tearfulness 13.76 9.86 34 223926 4746 90399741
Kidney infection 13.73 9.86 27 223933 25889 90378598
Pseudomonas infection 13.73 9.86 10 223950 14855 90389632
Hypophosphataemia 13.71 9.86 10 223950 14844 90389643
Toxic encephalopathy 13.70 9.86 50 223910 8649 90395838
Conjunctival ulcer 13.63 9.86 5 223955 45 90404442
Hallucination, olfactory 13.58 9.86 9 223951 315 90404172
Cardiomyopathy 13.57 9.86 18 223942 20188 90384299
Emotional disorder 13.55 9.86 73 223887 14924 90389563
Hyperventilation 13.55 9.86 42 223918 6686 90397801
Device difficult to use 13.50 9.86 14 223946 17511 90386976
Rash vesicular 13.46 9.86 84 223876 18113 90386374
Agranulocytosis 13.44 9.86 139 223821 34863 90369624
Echolalia 13.35 9.86 9 223951 324 90404163
Bronchospasm 13.35 9.86 19 223941 20690 90383797
Delusional perception 13.35 9.86 8 223952 234 90404253
Sensory loss 13.30 9.86 15 223945 18060 90386427
Foetal heart rate deceleration abnormality 13.29 9.86 12 223948 667 90403820
Congenital ureteric anomaly 13.27 9.86 6 223954 96 90404391
Muscle spasms 13.25 9.86 755 223205 251128 90153359
Diabetes mellitus inadequate control 13.22 9.86 16 223944 18668 90385819
Retinal pigmentation 13.16 9.86 6 223954 98 90404389
Polydipsia 13.15 9.86 31 223929 4200 90400287
Gastrointestinal injury 13.14 9.86 13 223947 811 90403676
Selective IgG subclass deficiency 13.07 9.86 4 223956 19 90404468
Juvenile myoclonic epilepsy 13.07 9.86 4 223956 19 90404468
Alcoholism 13.04 9.86 19 223941 1781 90402706
Myocarditis 13.02 9.86 68 223892 13738 90390749
Lower gastrointestinal haemorrhage 13.00 9.86 3 223957 8889 90395598
Respiratory failure 12.97 9.86 210 223750 118208 90286279
Multiple allergies 12.96 9.86 11 223949 15135 90389352
Groin pain 12.95 9.86 7 223953 12206 90392281
Congenital emphysema 12.95 9.86 3 223957 3 90404484
Niemann-Pick disease 12.95 9.86 3 223957 3 90404484
Rales 12.94 9.86 12 223948 15815 90388672
Enuresis 12.85 9.86 27 223933 3387 90401100
Emphysema 12.84 9.86 7 223953 12148 90392339
Epidermolysis 12.84 9.86 12 223948 697 90403790
Foetal malnutrition 12.84 9.86 6 223954 104 90404383
Abortion 12.80 9.86 24 223936 2771 90401716
Bone marrow failure 12.79 9.86 39 223921 32182 90372305
Ventricular arrhythmia 12.72 9.86 31 223929 4290 90400197
Pemphigus 12.71 9.86 669 223291 326195 90078292
Blood urea increased 12.66 9.86 36 223924 30377 90374110
Breast cancer stage I 12.65 9.86 4 223956 9620 90394867
Brain stem syndrome 12.63 9.86 12 223948 712 90403775
Hepatic enzyme increased 12.62 9.86 746 223214 359990 90044497
Arteriosclerosis coronary artery 12.61 9.86 4 223956 9599 90394888
Fibromyalgia 12.59 9.86 627 223333 205642 90198845
Victim of crime 12.52 9.86 13 223947 859 90403628
Glomerular filtration rate decreased 12.52 9.86 14 223946 16918 90387569
Foreign body in reproductive tract 12.52 9.86 15 223945 1162 90403325
Osteonecrosis 12.51 9.86 29 223931 26212 90378275
Cushingoid 12.51 9.86 5 223955 10390 90394097
Directional Doppler flow tests abnormal 12.49 9.86 3 223957 4 90404483
Glycosylated haemoglobin increased 12.48 9.86 12 223948 15550 90388937
Hypercapnic coma 12.46 9.86 8 223952 265 90404222
Viral upper respiratory tract infection 12.45 9.86 3 223957 8631 90395856
Holoprosencephaly 12.44 9.86 4 223956 23 90404464
Foetal growth restriction 12.40 9.86 51 223909 9329 90395158
Cardiac aneurysm 12.39 9.86 14 223946 1018 90403469
SARS-CoV-2 test positive 12.37 9.86 6 223954 11122 90393365
Blunted affect 12.35 9.86 8 223952 269 90404218
Ideas of reference 12.34 9.86 6 223954 114 90404373
Cleft lip 12.32 9.86 7 223953 185 90404302
Klebsiella infection 12.31 9.86 5 223955 10292 90394195
Bromoderma 12.30 9.86 4 223956 24 90404463
Epilepsy surgery 12.30 9.86 4 223956 24 90404463
Therapy interrupted 12.26 9.86 73 223887 50035 90354452
Renal disorder 12.23 9.86 50 223910 37809 90366678
Tonic clonic movements 12.22 9.86 18 223942 1704 90402783
Renal injury 12.20 9.86 5 223955 10238 90394249
Bradyphrenia 12.20 9.86 44 223916 7568 90396919
Drug screen positive 12.19 9.86 28 223932 3729 90400758
Eclampsia 12.18 9.86 10 223950 488 90403999
Drug dose omission by device 12.18 9.86 5 223955 10226 90394261
Cogwheel rigidity 12.16 9.86 20 223940 2082 90402405
Paroxysmal perceptual alteration 12.13 9.86 5 223955 63 90404424
Transaminases increased 12.13 9.86 143 223817 37049 90367438
Compulsive cheek biting 12.09 9.86 3 223957 5 90404482
Laryngeal tremor 12.09 9.86 3 223957 5 90404482
Tooth disorder 12.08 9.86 38 223922 31052 90373435
Oral mucosal erythema 12.06 9.86 18 223942 1724 90402763
Dermatitis bullous 12.03 9.86 54 223906 10262 90394225
Wrong schedule 11.99 9.86 9 223951 385 90404102
Cardiovascular symptom 11.97 9.86 6 223954 122 90404365
Rotator cuff syndrome 11.95 9.86 13 223947 15906 90388581
Spinal disorder 11.95 9.86 7 223953 11672 90392815
Lupus vulgaris 11.91 9.86 64 223896 44995 90359492
Selective IgA immunodeficiency 11.90 9.86 4 223956 27 90404460
Musculoskeletal discomfort 11.89 9.86 21 223939 20970 90383517
Unevaluable event 11.84 9.86 83 223877 54765 90349722
Inflammatory marker increased 11.81 9.86 4 223956 9210 90395277
Aspergillus infection 11.78 9.86 6 223954 10817 90393670
Stupor 11.77 9.86 35 223925 5447 90399040
Upper-airway cough syndrome 11.76 9.86 12 223948 15123 90389364
Acute coronary syndrome 11.76 9.86 6 223954 10807 90393680
Prescribed overdose 11.76 9.86 170 223790 97455 90307032
Diabetes mellitus 11.76 9.86 103 223857 64772 90339715
Lymph node pain 11.76 9.86 18 223942 1763 90402724
Atrophy of globe 11.74 9.86 3 223957 6 90404481
Wound healing normal 11.74 9.86 3 223957 6 90404481
Ligneous conjunctivitis 11.74 9.86 3 223957 6 90404481
Delusion of reference 11.71 9.86 6 223954 128 90404359
Neurotoxicity 11.71 9.86 92 223868 21375 90383112
Skin discolouration 11.68 9.86 63 223897 44252 90360235
Speech disorder developmental 11.68 9.86 13 223947 930 90403557
Aspergillus test positive 11.67 9.86 9 223951 401 90404086
Lymphoid tissue hyperplasia 11.58 9.86 7 223953 208 90404279
Lip disorder 11.57 9.86 17 223943 1605 90402882
Hypoacusis 11.57 9.86 33 223927 27817 90376670
Skin haemorrhage 11.56 9.86 22 223938 21358 90383129
Bone erosion 11.56 9.86 80 223880 52941 90351546
Corneal erosion 11.52 9.86 9 223951 409 90404078
Lymphocyte count decreased 11.51 9.86 46 223914 35004 90369483
Disease recurrence 11.51 9.86 143 223817 37510 90366977
Erysipelas 11.48 9.86 4 223956 9048 90395439
Pyelonephritis 11.47 9.86 22 223938 21294 90383193
COVID-19 pneumonia 11.40 9.86 17 223943 18160 90386327
Therapeutic product effect decreased 11.38 9.86 565 223395 277006 90127481
Haemangioma 11.38 9.86 24 223936 3018 90401469
Bankruptcy 11.31 9.86 4 223956 32 90404455
Paralogism 11.31 9.86 4 223956 32 90404455
Decreased interest 11.29 9.86 30 223930 4377 90400110
Blood oestrogen increased 11.29 9.86 7 223953 218 90404269
Hand deformity 11.25 9.86 608 223352 295754 90108733
Limb injury 11.22 9.86 40 223920 31468 90373019
Incorrect product administration duration 11.20 9.86 84 223876 19238 90385249
Large intestine perforation 11.16 9.86 5 223955 9707 90394780
Hyperhidrosis 11.16 9.86 254 223706 136051 90268436
Unemployment 11.14 9.86 3 223957 8 90404479
Mucosal ulceration 11.14 9.86 14 223946 1139 90403348
Distichiasis 11.10 9.86 4 223956 34 90404453
Blood glucose decreased 11.09 9.86 26 223934 23403 90381084
Potentiating drug interaction 11.08 9.86 35 223925 5627 90398860
Crepitations 11.08 9.86 4 223956 8848 90395639
Feeling cold 11.08 9.86 33 223927 27432 90377055
C-reactive protein 11.05 9.86 40 223920 31327 90373160
Agoraphobia 11.04 9.86 10 223950 558 90403929
Blood cholesterol increased 11.03 9.86 624 223336 207388 90197099
Phonophobia 11.00 9.86 9 223951 437 90404050
Hepatic necrosis 11.00 9.86 38 223922 6400 90398087
Middle insomnia 10.97 9.86 75 223885 16676 90387811
Post procedural haemorrhage 10.97 9.86 4 223956 8794 90395693
Cerebral disorder 10.97 9.86 35 223925 5659 90398828
Skin infection 10.92 9.86 17 223943 17847 90386640
Substance-induced psychotic disorder 10.92 9.86 23 223937 2889 90401598
Perinatal depression 10.91 9.86 12 223948 847 90403640
Atlantoaxial subluxation 10.88 9.86 3 223957 9 90404478
Lactation disorder 10.86 9.86 9 223951 445 90404042
Ileus 10.85 9.86 15 223945 16531 90387956
Escherichia infection 10.84 9.86 14 223946 15881 90388606
Decubitus ulcer 10.84 9.86 8 223952 11805 90392682
Vagal nerve stimulator implantation 10.80 9.86 4 223956 37 90404450
Neurosurgery 10.79 9.86 5 223955 85 90404402
Retroperitoneal fibrosis 10.79 9.86 8 223952 336 90404151
Chorea 10.78 9.86 19 223941 2091 90402396
Apnoea 10.77 9.86 49 223911 9365 90395122
Mobility decreased 10.75 9.86 508 223452 250226 90154261
Affect lability 10.74 9.86 79 223881 17984 90386503
Corneal lesion 10.71 9.86 4 223956 38 90404449
Anembryonic gestation 10.68 9.86 10 223950 582 90403905
Homeless 10.68 9.86 5 223955 87 90404400
Pulmonary artery stenosis congenital 10.67 9.86 9 223951 456 90404031
Wheelchair user 10.66 9.86 3 223957 7782 90396705
Alexia 10.64 9.86 3 223957 10 90404477
Amylase abnormal 10.62 9.86 4 223956 39 90404448
Psoriatic arthropathy 10.61 9.86 677 223283 227658 90176829
Antipsychotic drug level above therapeutic 10.60 9.86 15 223945 1369 90403118
Status migrainosus 10.58 9.86 6 223954 158 90404329
Premature rupture of membranes 10.55 9.86 34 223926 5524 90398963
Therapeutic response decreased 10.54 9.86 157 223803 89572 90314915
Ecchymosis 10.48 9.86 9 223951 12314 90392173
Blood loss anaemia 10.48 9.86 6 223954 10134 90394353
Coronary artery occlusion 10.48 9.86 4 223956 8550 90395937
Nasal polyps 10.47 9.86 7 223953 10873 90393614
Progressive multifocal leukoencephalopathy 10.46 9.86 14 223946 15641 90388846
Periodic limb movement disorder 10.43 9.86 10 223950 600 90403887
Arteriosclerosis 10.42 9.86 7 223953 10846 90393641
Nikolsky's sign 10.38 9.86 5 223955 93 90404394
Drug titration error 10.36 9.86 14 223946 1223 90403264
Acute myopia 10.31 9.86 6 223954 166 90404321
Hyperacusis 10.31 9.86 22 223938 2789 90401698
Blood pressure systolic decreased 10.30 9.86 5 223955 9265 90395222
Menstrual disorder 10.29 9.86 36 223924 6102 90398385
Anticonvulsant drug level abnormal 10.27 9.86 4 223956 43 90404444
Tonsillar haemorrhage 10.24 9.86 7 223953 258 90404229
Intestinal obstruction 10.23 9.86 52 223908 37079 90367408
Laboratory test abnormal 10.22 9.86 61 223899 41793 90362694
Sexual abuse 10.22 9.86 7 223953 259 90404228
Compulsive shopping 10.22 9.86 11 223949 758 90403729
Substance abuse 10.20 9.86 33 223927 5373 90399114
Device malfunction 10.15 9.86 23 223937 20954 90383533
Impaired driving ability 10.15 9.86 32 223928 5141 90399346
Mental status changes 10.15 9.86 161 223799 44518 90359969
Cardiovascular disorder 10.14 9.86 11 223949 13481 90391006
Coagulopathy 10.12 9.86 27 223933 23262 90381225
Psychogenic seizure 10.10 9.86 18 223942 1998 90402489
Hypernatraemia 10.10 9.86 48 223912 9339 90395148
Dermatosis 10.09 9.86 10 223950 625 90403862
Atelectasis 10.08 9.86 29 223931 24380 90380107
Diabetic ketoacidosis 10.08 9.86 29 223931 24378 90380109
Neonatal behavioural syndrome 10.05 9.86 5 223955 100 90404387
Bundle branch block right 10.03 9.86 33 223927 5420 90399067
Systemic candida 10.03 9.86 31 223929 4928 90399559
Joint injury 10.02 9.86 44 223916 32620 90371867
Carotid artery thrombosis 9.96 9.86 5 223955 9087 90395400
Post procedural complication 9.95 9.86 20 223940 19022 90385465
Accidental death 9.90 9.86 18 223942 2030 90402457
Cellulitis orbital 9.89 9.86 10 223950 640 90403847
Blood creatine phosphokinase increased 9.88 9.86 128 223832 33895 90370592

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 1641.47 12.06 1531 77961 119030 42422813
Foetal exposure during pregnancy 1101.85 12.06 821 78671 46490 42495353
Completed suicide 791.12 12.06 936 78556 95529 42446314
Stevens-Johnson syndrome 741.70 12.06 481 79011 21697 42520146
Generalised tonic-clonic seizure 589.59 12.06 447 79045 25932 42515911
Drug reaction with eosinophilia and systemic symptoms 556.39 12.06 527 78965 41548 42500295
Toxicity to various agents 535.22 12.06 1261 78231 227875 42313968
Ataxia 510.42 12.06 338 79154 15787 42526056
Status epilepticus 506.38 12.06 332 79160 15246 42526597
Aggression 454.72 12.06 483 79009 43680 42498163
Epilepsy 437.05 12.06 374 79118 25797 42516046
Product substitution issue 404.88 12.06 256 79236 11034 42530809
Exposure during pregnancy 337.30 12.06 206 79286 8342 42533501
Suicide attempt 324.94 12.06 415 79077 45685 42496158
Intentional overdose 298.13 12.06 421 79071 51035 42490808
Multiple-drug resistance 295.43 12.06 179 79313 7143 42534700
Febrile neutropenia 294.71 12.06 12 79480 185691 42356152
Drug interaction 293.16 12.06 1126 78366 265873 42275970
Toxic epidermal necrolysis 292.07 12.06 302 79190 26448 42515395
Agitation 280.34 12.06 461 79031 63853 42477990
Atrial septal defect 270.10 12.06 174 79318 7745 42534098
Somnolence 259.08 12.06 710 78782 140395 42401448
Diarrhoea 251.07 12.06 295 79197 460554 42081289
Dyspnoea 244.67 12.06 280 79212 442341 42099502
Drug level increased 232.19 12.06 265 79227 25935 42515908
Irritability 208.89 12.06 260 79232 27868 42513975
Mania 207.86 12.06 166 79326 10381 42531462
Anaemia 201.88 12.06 138 79354 280140 42261703
Suicidal ideation 201.46 12.06 339 79153 47822 42494021
Electrocardiogram QRS complex prolonged 198.71 12.06 128 79364 5695 42536148
Petit mal epilepsy 197.40 12.06 108 79384 3542 42538301
Partial seizures 193.08 12.06 126 79366 5733 42536110
Abnormal behaviour 190.84 12.06 241 79251 26210 42515633
Pneumonia 184.27 12.06 316 79176 421833 42120010
Death 181.79 12.06 380 79112 470805 42071038
Coma 180.43 12.06 343 79149 53211 42488632
Exposure via breast milk 178.95 12.06 89 79403 2388 42539455
Hypospadias 175.02 12.06 99 79393 3468 42538375
Rash 173.98 12.06 993 78499 275961 42265882
Overdose 171.90 12.06 508 78984 104756 42437087
Sudden unexplained death in epilepsy 163.14 12.06 54 79438 475 42541368
Acute kidney injury 152.93 12.06 283 79209 367054 42174789
Infantile apnoea 152.86 12.06 63 79429 1073 42540770
Maternal exposure during pregnancy 146.47 12.06 114 79378 6864 42534979
Brugada syndrome 143.74 12.06 59 79433 994 42540849
Respiratory disorder neonatal 140.00 12.06 70 79422 1900 42539943
Patent ductus arteriosus 135.14 12.06 83 79409 3393 42538450
Focal dyscognitive seizures 131.12 12.06 61 79431 1406 42540437
Neonatal respiratory distress syndrome 127.00 12.06 88 79404 4425 42537418
Disease progression 124.55 12.06 56 79436 143600 42398243
Developmental delay 123.76 12.06 76 79416 3106 42538737
Autism spectrum disorder 122.98 12.06 74 79418 2914 42538929
Intentional self-injury 121.72 12.06 146 79346 15056 42526787
Maternal exposure during breast feeding 121.67 12.06 59 79433 1496 42540347
Dysmorphism 120.87 12.06 76 79416 3240 42538603
Arthralgia 120.57 12.06 123 79369 205115 42336728
Electroencephalogram abnormal 120.31 12.06 73 79419 2919 42538924
Cardiac failure congestive 119.37 12.06 11 79481 85591 42456252
Maternal drugs affecting foetus 117.87 12.06 79 79413 3760 42538083
Ventricular septal defect 117.32 12.06 83 79409 4316 42537527
Malignant neoplasm progression 117.05 12.06 29 79463 108371 42433472
Cognitive disorder 116.45 12.06 220 79272 33952 42507891
Atrial fibrillation 115.52 12.06 58 79434 139535 42402308
Myocardial infarction 112.84 12.06 45 79447 123964 42417879
Attention deficit hyperactivity disorder 112.71 12.06 71 79421 3037 42538806
Hypomania 110.76 12.06 65 79427 2443 42539400
Congenital anomaly 110.23 12.06 55 79437 1486 42540357
Psychomotor hyperactivity 107.64 12.06 117 79375 10841 42531002
Neuroleptic malignant syndrome 107.35 12.06 164 79328 21308 42520535
Pain 106.79 12.06 183 79309 244665 42297178
Myoclonus 106.79 12.06 145 79347 16920 42524923
Drug eruption 106.68 12.06 170 79322 22905 42518938
Tremor 106.03 12.06 409 79083 96520 42445323
Drug withdrawal syndrome neonatal 104.92 12.06 78 79414 4383 42537460
Cardiac failure 103.58 12.06 35 79457 106821 42435022
Selective eating disorder 100.40 12.06 54 79438 1710 42540133
Speech disorder developmental 100.33 12.06 59 79433 2226 42539617
Serotonin syndrome 98.94 12.06 175 79317 25670 42516173
Toxic optic neuropathy 98.44 12.06 45 79447 995 42540848
Rash maculo-papular 96.51 12.06 215 79277 37288 42504555
Hallucination, auditory 95.60 12.06 128 79364 14736 42527107
Sepsis 94.41 12.06 141 79351 199193 42342650
Hypotonia neonatal 91.73 12.06 48 79444 1436 42540407
Obsessive-compulsive disorder 90.03 12.06 85 79407 6658 42535185
Oculogyric crisis 89.33 12.06 50 79442 1715 42540128
Accidental exposure to product by child 89.28 12.06 48 79444 1519 42540324
Conjunctival hyperaemia 87.19 12.06 61 79431 3115 42538728
Disturbance in attention 85.76 12.06 179 79313 29687 42512156
Oral mucosa erosion 84.35 12.06 41 79451 1045 42540798
Bipolar disorder 84.33 12.06 65 79427 3857 42537986
Cough 84.30 12.06 126 79366 177977 42363866
Lip erosion 83.92 12.06 35 79457 615 42541228
Sedation 83.28 12.06 179 79313 30296 42511547
Abdominal pain 82.40 12.06 143 79349 190328 42351515
Pulmonary embolism 81.86 12.06 62 79430 119550 42422293
Neonatal infection 81.27 12.06 31 79461 426 42541417
Crying 80.44 12.06 78 79414 6316 42535527
Pain in extremity 79.91 12.06 98 79394 150506 42391337
Aura 79.81 12.06 30 79462 395 42541448
Apathy 79.52 12.06 88 79404 8318 42533525
Bradycardia neonatal 78.79 12.06 42 79450 1306 42540537
Balance disorder 78.67 12.06 231 79261 47414 42494429
Oedema peripheral 78.21 12.06 83 79409 135993 42405850
Postictal psychosis 78.05 12.06 25 79467 196 42541647
Interstitial lung disease 77.25 12.06 25 79467 78437 42463406
Premature baby 76.33 12.06 147 79345 23006 42518837
Nystagmus 75.85 12.06 70 79422 5326 42536517
COVID-19 75.70 12.06 63 79429 115885 42425958
Neurodevelopmental disorder 74.08 12.06 29 79463 429 42541414
Psychotic disorder 73.52 12.06 166 79326 29042 42512801
Depression 73.40 12.06 405 79087 110958 42430885
Neutropenia 73.11 12.06 165 79327 199266 42342577
Partial seizures with secondary generalisation 72.61 12.06 28 79464 397 42541446
Dysarthria 72.54 12.06 200 79292 39607 42502236
Coronary artery disease 72.02 12.06 8 79484 53712 42488131
Neuropathy peripheral 72.02 12.06 51 79441 101802 42440041
Diplopia 71.95 12.06 133 79359 20183 42521660
Wrong patient received product 71.88 12.06 57 79435 3526 42538317
Tardive dyskinesia 71.64 12.06 76 79416 6848 42534995
Back pain 71.33 12.06 96 79396 141680 42400163
Agitation neonatal 71.04 12.06 40 79452 1388 42540455
Restlessness 70.05 12.06 163 79329 29086 42512757
Anticonvulsant drug level above therapeutic 67.95 12.06 31 79461 682 42541161
Thinking abnormal 67.80 12.06 75 79417 7086 42534757
Blood prolactin increased 67.47 12.06 46 79446 2252 42539591
Anger 67.29 12.06 101 79391 12917 42528926
Behaviour disorder 66.99 12.06 74 79418 6980 42534863
Haemophagocytic lymphohistiocytosis 66.69 12.06 121 79371 18101 42523742
Joint swelling 66.39 12.06 22 79470 68000 42473843
Rheumatoid arthritis 66.37 12.06 3 79489 42437 42499406
Talipes 66.22 12.06 45 79447 2191 42539652
Psychomotor retardation 65.62 12.06 59 79433 4340 42537503
Gastrointestinal haemorrhage 65.15 12.06 52 79440 97674 42444169
Dyskinesia 64.68 12.06 145 79347 25245 42516598
Excessive eye blinking 64.59 12.06 29 79463 614 42541229
Pleural effusion 64.41 12.06 52 79440 97114 42444729
Gaze palsy 62.84 12.06 41 79451 1864 42539979
Chronic obstructive pulmonary disease 62.32 12.06 20 79472 63094 42478749
Infection 61.48 12.06 71 79421 111997 42429846
Developmental coordination disorder 60.79 12.06 21 79471 213 42541630
Poisoning deliberate 60.22 12.06 84 79408 10050 42531793
Psychogenic seizure 59.39 12.06 25 79467 450 42541393
Platelet count decreased 59.03 12.06 105 79387 138476 42403367
Antipsychotic drug level increased 58.85 12.06 57 79435 4609 42537234
Cytokine release syndrome 58.77 12.06 7 79485 44520 42497323
Infusion related reaction 57.05 12.06 21 79471 60785 42481058
Weight decreased 56.95 12.06 198 79294 207750 42334093
Haemoglobin decreased 56.76 12.06 100 79392 132371 42409472
Dystonia 56.07 12.06 92 79400 12698 42529145
Anxiety 56.06 12.06 396 79096 118164 42423679
Nausea 55.78 12.06 473 79019 396326 42145517
Tonic convulsion 55.45 12.06 36 79456 1623 42540220
Intellectual disability 55.22 12.06 38 79454 1889 42539954
Drug resistance 54.58 12.06 164 79328 34084 42507759
Postictal paralysis 54.46 12.06 22 79470 355 42541488
Renal impairment 54.06 12.06 76 79416 110152 42431691
Bipolar I disorder 53.74 12.06 28 79464 830 42541013
Hyperkalaemia 53.39 12.06 43 79449 80415 42461428
Anticonvulsant drug level increased 53.31 12.06 35 79457 1608 42540235
Hypoplastic left heart syndrome 52.98 12.06 19 79473 217 42541626
Mydriasis 52.57 12.06 73 79419 8697 42533146
Ascites 52.46 12.06 20 79472 56658 42485185
Mood altered 52.35 12.06 81 79411 10637 42531206
Cleft palate 52.28 12.06 25 79467 614 42541229
Neonatal tachypnoea 51.25 12.06 21 79471 352 42541491
Dyspnoea exertional 51.12 12.06 15 79477 50133 42491710
Asthenia 50.92 12.06 311 79181 280482 42261361
Speech disorder 50.77 12.06 144 79348 28977 42512866
SJS-TEN overlap 50.63 12.06 25 79467 660 42541183
Haematochezia 50.25 12.06 23 79469 58413 42483430
Conjunctivitis 50.01 12.06 88 79404 12851 42528992
Neonatal behavioural syndrome 49.97 12.06 17 79475 164 42541679
Overweight 49.74 12.06 39 79453 2373 42539470
Learning disorder 49.55 12.06 29 79463 1084 42540759
Myelosuppression 49.54 12.06 8 79484 40453 42501390
Anticonvulsant drug level decreased 49.54 12.06 30 79462 1195 42540648
Poisoning 49.27 12.06 94 79398 14605 42527238
Memory impairment 48.53 12.06 204 79288 50018 42491825
Tubulointerstitial nephritis and uveitis syndrome 48.18 12.06 15 79477 106 42541737
Anomaly of external ear congenital 48.18 12.06 15 79477 106 42541737
Erythema multiforme 48.17 12.06 75 79417 9902 42531941
Small for dates baby 47.90 12.06 54 79438 5209 42536634
Delusion 47.89 12.06 93 79399 14641 42527202
Arthritis 47.89 12.06 10 79482 42055 42499788
Off label use 47.67 12.06 872 78620 637463 41904380
Therapeutic response unexpected 47.39 12.06 80 79412 11301 42530542
Oscillopsia 47.34 12.06 18 79474 245 42541598
Dysmetria 47.17 12.06 25 79467 768 42541075
Salivary hypersecretion 47.01 12.06 78 79414 10865 42530978
Polydactyly 46.78 12.06 29 79463 1205 42540638
Dyspraxia 46.45 12.06 21 79471 452 42541391
Productive cough 46.40 12.06 19 79473 51548 42490295
Prostate cancer 46.15 12.06 13 79479 44630 42497213
Respiratory failure 46.11 12.06 107 79385 128025 42413818
Temperature regulation disorder 45.88 12.06 28 79464 1131 42540712
Atonic seizures 45.77 12.06 20 79472 396 42541447
Cerebrovascular accident 45.67 12.06 69 79423 97091 42444752
Plasma cell myeloma 45.36 12.06 16 79476 47562 42494281
Hypertension 45.22 12.06 160 79332 167044 42374799
Foetal anticonvulsant syndrome 44.94 12.06 28 79464 1174 42540669
Staring 44.85 12.06 31 79461 1552 42540291
Hypotension 44.81 12.06 289 79203 257342 42284501
Abulia 44.61 12.06 23 79469 667 42541176
Respiratory acidosis 44.56 12.06 57 79435 6274 42535569
Decreased appetite 44.49 12.06 197 79295 192940 42348903
Tonic clonic movements 44.06 12.06 29 79463 1338 42540505
Acute myocardial infarction 43.97 12.06 27 79465 58138 42483705
Tic 43.76 12.06 36 79456 2347 42539496
Deep vein thrombosis 43.01 12.06 48 79444 76909 42464934
Withdrawal syndrome 42.92 12.06 89 79403 14686 42527157
Blood creatine phosphokinase increased 42.61 12.06 191 79301 48147 42493696
Hypotonia 42.55 12.06 69 79423 9430 42532413
Cardio-respiratory arrest 42.52 12.06 219 79273 58417 42483426
Educational problem 42.44 12.06 21 79471 557 42541286
Paroxysmal perceptual alteration 42.33 12.06 16 79476 214 42541629
Cryptorchism 42.29 12.06 33 79459 1994 42539849
General physical health deterioration 42.06 12.06 143 79349 151103 42390740
Rectal haemorrhage 41.92 12.06 20 79472 49586 42492257
Epistaxis 41.55 12.06 38 79454 66788 42475055
Blister 41.34 12.06 129 79363 27361 42514482
Feeling drunk 41.23 12.06 34 79458 2224 42539619
Myoclonic epilepsy 41.01 12.06 30 79462 1644 42540199
Retinal pigment epitheliopathy 40.91 12.06 16 79476 236 42541607
Encephalopathy 40.80 12.06 169 79323 41164 42500679
Herpes zoster 40.79 12.06 11 79481 38866 42502977
Haemorrhage 40.64 12.06 32 79460 60531 42481312
Pancytopenia 40.24 12.06 101 79391 117642 42424201
Altered state of consciousness 40.09 12.06 133 79359 29126 42512717
Haemoptysis 39.96 12.06 18 79474 46149 42495694
Drug titration error 39.80 12.06 22 79470 736 42541107
Nasal septum disorder 39.58 12.06 11 79481 49 42541794
Septic shock 39.43 12.06 69 79423 91603 42450240
Psychiatric symptom 39.43 12.06 44 79448 4197 42537646
Renal failure 39.21 12.06 137 79355 143589 42398254
Intentional product use issue 38.85 12.06 46 79446 71787 42470056
Drug ineffective 38.70 12.06 1487 78005 628710 41913133
Depressed level of consciousness 38.20 12.06 184 79308 47786 42494057
Anticonvulsant drug level below therapeutic 38.17 12.06 21 79471 696 42541147
Mucosal disorder 38.17 12.06 32 79460 2142 42539701
Microcephaly 38.10 12.06 23 79469 911 42540932
Gout 38.06 12.06 4 79488 28051 42513792
Insomnia 38.05 12.06 362 79130 117891 42423952
Lung disorder 37.99 12.06 21 79471 47902 42493941
Wheezing 37.96 12.06 28 79464 54753 42487090
Treatment noncompliance 37.94 12.06 155 79337 37517 42504326
Suspected suicide 37.76 12.06 52 79440 6147 42535696
Disorientation 37.67 12.06 151 79341 36238 42505605
Cardiogenic shock 37.55 12.06 10 79482 35630 42506213
Chest pain 37.39 12.06 134 79358 139396 42402447
Coarctation of the aorta 37.10 12.06 18 79474 457 42541386
Eyelid erosion 37.01 12.06 7 79485 0 42541843
Congenital diaphragmatic hernia 36.96 12.06 15 79477 245 42541598
Logorrhoea 36.74 12.06 35 79457 2772 42539071
Pneumonitis 36.53 12.06 16 79476 41702 42500141
Colitis 36.07 12.06 21 79471 46551 42495292
Burnout syndrome 36.05 12.06 13 79479 151 42541692
Pyloric stenosis 35.67 12.06 22 79470 906 42540937
Motor developmental delay 35.60 12.06 20 79472 691 42541152
Hallucination, visual 34.76 12.06 102 79390 20918 42520925
Peripheral swelling 34.42 12.06 73 79419 90197 42451646
Neonatal hypoxia 34.29 12.06 18 79474 542 42541301
Chills 34.27 12.06 78 79414 93988 42447855
Cytomegalovirus infection 34.16 12.06 9 79483 32297 42509546
Depressive symptom 34.16 12.06 39 79453 3814 42538029
Hypomagnesaemia 34.06 12.06 6 79486 28482 42513361
Strabismus 34.05 12.06 31 79461 2317 42539526
Akathisia 34.00 12.06 66 79426 10385 42531458
Change in seizure presentation 33.92 12.06 15 79477 306 42541537
Accidental overdose 33.80 12.06 123 79369 28207 42513636
Arthropathy 33.76 12.06 7 79485 29590 42512253
Depressed mood 33.57 12.06 108 79384 23276 42518567
Personality disorder 33.48 12.06 23 79469 1140 42540703
Limb reduction defect 33.43 12.06 15 79477 317 42541526
Delirium 33.23 12.06 189 79303 52330 42489513
Impulsive behaviour 33.20 12.06 31 79461 2394 42539449
Abdominal pain upper 33.03 12.06 65 79427 82544 42459299
Pulmonary hypoplasia 32.84 12.06 17 79475 497 42541346
Neoplasm progression 32.79 12.06 7 79485 28993 42512850
Coordination abnormal 32.74 12.06 56 79436 7994 42533849
Fatigue 32.74 12.06 594 78898 435047 42106796
Major depression 32.46 12.06 45 79447 5353 42536490
Retrognathia 32.28 12.06 14 79478 272 42541571
Mucosal inflammation 31.99 12.06 27 79465 49347 42492496
Affective disorder 31.89 12.06 47 79445 5913 42535930
Developmental regression 31.70 12.06 9 79483 44 42541799
Catatonia 31.66 12.06 48 79444 6191 42535652
Gait disturbance 31.52 12.06 300 79192 97700 42444143
Body dysmorphic disorder 31.38 12.06 12 79480 166 42541677
Parasomnia 31.38 12.06 16 79476 453 42541390
Tachyphrenia 31.27 12.06 24 79468 1415 42540428
Paranoia 31.23 12.06 76 79416 13950 42527893
Illusion 31.17 12.06 21 79471 1008 42540835
Neonatal asphyxia 31.16 12.06 16 79476 460 42541383
Pulmonary fibrosis 31.08 12.06 6 79486 26675 42515168
Affect lability 31.00 12.06 38 79454 4006 42537837
Gambling disorder 30.89 12.06 26 79466 1750 42540093
Confusional state 30.84 12.06 461 79031 167136 42374707
Bipolar II disorder 30.76 12.06 8 79484 26 42541817
Cardiac septal hypertrophy 30.73 12.06 15 79477 386 42541457
Drooling 30.72 12.06 39 79453 4260 42537583
Psychomotor skills impaired 30.72 12.06 43 79449 5161 42536682
Feelings of worthlessness 30.60 12.06 14 79478 310 42541533
Blood creatinine increased 30.57 12.06 104 79388 109899 42431944
Bacteraemia 30.54 12.06 5 79487 25035 42516808
Hypertonia 30.53 12.06 42 79450 4959 42536884
Hypoxia 30.49 12.06 52 79440 69734 42472109
Plagiocephaly 30.32 12.06 17 79475 585 42541258
Convulsive threshold lowered 29.97 12.06 16 79476 499 42541344
Movement disorder 29.95 12.06 77 79415 14621 42527222
Abdominal distension 29.94 12.06 55 79437 71680 42470163
Atrioventricular septal defect 29.86 12.06 13 79479 255 42541588
Suspiciousness 29.77 12.06 15 79477 414 42541429
Wrong schedule 29.76 12.06 14 79478 331 42541512
Dissociation 29.62 12.06 36 79456 3762 42538081
Nasopharyngitis 29.52 12.06 71 79421 83925 42457918
Angular cheilitis 29.40 12.06 12 79480 199 42541644
Mental disorder 29.35 12.06 87 79405 17942 42523901
Haemangioma congenital 29.28 12.06 16 79476 523 42541320
Rash erythematous 29.18 12.06 128 79364 31963 42509880
Frequent bowel movements 29.17 12.06 3 79489 21404 42520439
Thrombosis 29.06 12.06 52 79440 68459 42473384
Pulmonary oedema 28.92 12.06 34 79458 53238 42488605
Thrombocytopenia 28.85 12.06 222 79270 190057 42351786
Neonatal respiratory arrest 28.72 12.06 8 79484 36 42541807
Cerebral ventricle dilatation 28.62 12.06 20 79472 1019 42540824
Rash morbilliform 28.61 12.06 37 79455 4116 42537727
Abdominal discomfort 28.56 12.06 61 79431 75194 42466649
Inappropriate schedule of product administration 28.50 12.06 88 79404 95814 42446029
Influenza 28.40 12.06 45 79447 62130 42479713
Angina pectoris 28.20 12.06 13 79479 32883 42508960
Ischaemic stroke 28.12 12.06 4 79488 22229 42519614
Drop attacks 27.91 12.06 16 79476 575 42541268
Bicuspid aortic valve 27.81 12.06 13 79479 303 42541540
Eosinophil percentage increased 27.76 12.06 16 79476 581 42541262
Mental impairment 27.70 12.06 67 79425 12250 42529593
Lichen spinulosus 27.57 12.06 6 79486 6 42541837
Heart rate decreased 27.55 12.06 17 79475 36515 42505328
Apnoea 27.52 12.06 51 79441 7752 42534091
Epidermal necrosis 27.45 12.06 17 79475 705 42541138
Cleft lip 27.35 12.06 13 79479 315 42541528
Haematuria 27.19 12.06 41 79451 57758 42484085
Pilonidal cyst congenital 27.10 12.06 7 79485 22 42541821
Caesarean section 27.07 12.06 26 79466 2080 42539763
Kidney malformation 27.03 12.06 11 79481 181 42541662
Mucosal erosion 26.88 12.06 19 79473 986 42540857
Sopor 26.74 12.06 69 79423 13133 42528710
Constipation 26.69 12.06 185 79307 162106 42379737
Pneumocystis jirovecii pneumonia 26.65 12.06 7 79485 25174 42516669
Sinus tachycardia 26.64 12.06 92 79400 20561 42521282
Colitis ulcerative 26.36 12.06 8 79484 26167 42515676
Respiratory arrest 26.32 12.06 114 79378 28310 42513533
Psoriatic arthropathy 26.31 12.06 7 79485 24960 42516883
Face oedema 26.22 12.06 70 79422 13596 42528247
Renal aplasia 26.19 12.06 17 79475 766 42541077
Hyperhomocysteinaemia 26.14 12.06 12 79480 268 42541575
Hypophosphataemia 25.96 12.06 4 79488 20941 42520902
Compulsive shopping 25.92 12.06 14 79478 447 42541396
Tongue movement disturbance 25.85 12.06 10 79482 143 42541700
Large for dates baby 25.85 12.06 18 79474 912 42540931
Cleft lip and palate 25.82 12.06 18 79474 914 42540929
Blood pressure fluctuation 25.73 12.06 9 79483 26899 42514944
Cerebral infarction 25.67 12.06 13 79479 31156 42510687
Cerebral atrophy 25.67 12.06 39 79453 5040 42536803
Syncope 25.61 12.06 97 79395 99309 42442534
Bacterial infection 25.52 12.06 10 79482 27869 42513974
Schizophrenia 25.48 12.06 59 79433 10491 42531352
Chest discomfort 25.47 12.06 50 79442 63566 42478277
Drug level decreased 25.43 12.06 57 79435 9920 42531923
Appendicitis 25.40 12.06 4 79488 20609 42521234
Melaena 25.33 12.06 21 79471 38725 42503118
Chapped lips 25.25 12.06 18 79474 947 42540896
Hyperexplexia 25.22 12.06 7 79485 31 42541812
Hyperglycaemia 25.19 12.06 29 79463 45830 42496013
Bundle branch block right 24.93 12.06 50 79442 8056 42533787
Posture abnormal 24.90 12.06 27 79465 2494 42539349
Epispadias 24.89 12.06 10 79482 159 42541684
Derealisation 24.83 12.06 17 79475 838 42541005
Hypoglycaemia neonatal 24.77 12.06 25 79467 2125 42539718
Cardiac disorder 24.72 12.06 33 79459 48899 42492944
Disturbance in social behaviour 24.59 12.06 23 79469 1780 42540063
Emotional disorder 24.47 12.06 43 79449 6271 42535572
Eye discharge 24.35 12.06 29 79463 2966 42538877
Enanthema 24.27 12.06 15 79477 620 42541223
Cerebellar atrophy 24.24 12.06 16 79476 742 42541101
Congenital melanocytic naevus 24.23 12.06 6 79486 15 42541828
Wrong patient 24.18 12.06 15 79477 624 42541219
Aphasia 24.18 12.06 99 79393 23984 42517859
Obstructive airways disorder 24.16 12.06 8 79484 24751 42517092
Lethargy 24.14 12.06 160 79332 46730 42495113
Loss of consciousness 24.12 12.06 271 79221 92083 42449760
Drug withdrawal convulsions 24.12 12.06 20 79472 1318 42540525
Hypernatraemia 24.11 12.06 56 79436 9976 42531867
Cataplexy 24.10 12.06 13 79479 414 42541429
Metabolic function test abnormal 24.07 12.06 11 79481 243 42541600
Hepatic cirrhosis 23.88 12.06 4 79488 19698 42522145
Sinusitis 23.78 12.06 32 79460 47260 42494583
Mental status changes 23.71 12.06 147 79345 41968 42499875
Altered pitch perception 23.69 12.06 6 79486 17 42541826
False positive investigation result 23.67 12.06 15 79477 648 42541195
Tuberous sclerosis complex 23.62 12.06 8 79484 76 42541767
Peripheral circulatory failure 23.51 12.06 10 79482 185 42541658
Depersonalisation/derealisation disorder 23.49 12.06 15 79477 657 42541186
Fluid retention 23.45 12.06 15 79477 31604 42510239
Feeling jittery 23.39 12.06 35 79457 4463 42537380
Muscle rigidity 23.37 12.06 62 79430 11997 42529846
Myalgia 23.32 12.06 96 79396 95984 42445859
Muscle twitching 23.27 12.06 61 79431 11719 42530124
Contraindicated product administered 23.24 12.06 9 79483 25263 42516580
Exposure via ingestion 23.22 12.06 24 79468 2098 42539745
Full blood count decreased 23.17 12.06 5 79487 20555 42521288
Musculoskeletal pain 23.15 12.06 17 79475 33323 42508520
Mood swings 23.14 12.06 51 79441 8775 42533068
Electrocardiogram QT prolonged 23.13 12.06 161 79331 47784 42494059
Parkinsonism 23.06 12.06 57 79435 10566 42531277
Upper gastrointestinal haemorrhage 22.99 12.06 14 79478 30285 42511558
Transferrin increased 22.98 12.06 5 79487 5 42541838
Lung neoplasm malignant 22.96 12.06 4 79488 19143 42522700
Bone marrow failure 22.81 12.06 17 79475 33076 42508767
Poor feeding infant 22.71 12.06 16 79476 826 42541017
Clostridium difficile infection 22.68 12.06 7 79485 22652 42519191
Gangrene neonatal 22.57 12.06 10 79482 205 42541638
Obsessive thoughts 22.44 12.06 16 79476 842 42541001
Suicide threat 22.42 12.06 7 79485 50 42541793
Restless legs syndrome 22.38 12.06 53 79439 9561 42532282
Postictal state 22.14 12.06 17 79475 1003 42540840
Acute hepatic failure 21.97 12.06 76 79416 16997 42524846
Language disorder 21.85 12.06 25 79467 2450 42539393
Chronic kidney disease 21.75 12.06 34 79458 47207 42494636
Drug screen false positive 21.72 12.06 16 79476 886 42540957
Lymphadenopathy 21.71 12.06 121 79371 33244 42508599
Astrocytoma, low grade 21.66 12.06 8 79484 100 42541743
Blood pressure increased 21.65 12.06 107 79385 101821 42440022
Spina bifida 21.43 12.06 12 79480 412 42541431
Congenital hand malformation 21.39 12.06 14 79478 640 42541203
Hypercalcaemia 21.16 12.06 4 79488 18054 42523789
Mucosal exfoliation 21.15 12.06 4 79488 0 42541843
Laryngomalacia 21.08 12.06 11 79481 327 42541516
Congenital genital malformation male 20.96 12.06 5 79487 10 42541833
Brain malformation 20.89 12.06 9 79483 172 42541671
Psychotic symptom 20.86 12.06 24 79468 2366 42539477
Platelet distribution width decreased 20.86 12.06 6 79486 31 42541812
Multiple congenital abnormalities 20.82 12.06 13 79479 547 42541296
Osteonecrosis of jaw 20.73 12.06 5 79487 19044 42522799
Increased appetite 20.63 12.06 49 79443 8857 42532986
Panic attack 20.61 12.06 56 79436 10989 42530854
Skin turgor decreased 20.51 12.06 13 79479 562 42541281
Metastases to liver 20.50 12.06 3 79489 16323 42525520
Distractibility 20.47 12.06 12 79480 450 42541393
Aplasia cutis congenita 20.46 12.06 8 79484 118 42541725
Plateletcrit decreased 20.40 12.06 6 79486 34 42541809
Persecutory delusion 20.37 12.06 29 79463 3535 42538308
Oral disorder 20.27 12.06 34 79458 4778 42537065
Dyslexia 20.20 12.06 11 79481 357 42541486
Erythema of eyelid 20.17 12.06 19 79473 1484 42540359
Vision blurred 20.13 12.06 170 79322 53529 42488314
Hyperammonaemia 20.11 12.06 45 79447 7821 42534022
Hyperreflexia 20.10 12.06 29 79463 3578 42538265
Hyperbilirubinaemia neonatal 20.08 12.06 15 79477 849 42540994
Irregular sleep phase 20.04 12.06 8 79484 125 42541718
Blood potassium increased 19.91 12.06 5 79487 18531 42523312
Product dispensing error 19.87 12.06 44 79448 7595 42534248
Intelligence test abnormal 19.83 12.06 6 79486 38 42541805
Epileptic aura 19.78 12.06 5 79487 14 42541829
Enuresis 19.75 12.06 25 79467 2723 42539120
Suicidal behaviour 19.71 12.06 19 79473 1527 42540316
Aspergillus infection 19.68 12.06 3 79489 15834 42526009
Anal atresia 19.65 12.06 10 79482 282 42541561
Tachycardia foetal 19.61 12.06 11 79481 379 42541464
Swelling 19.59 12.06 46 79446 54839 42487004
Blood glucose increased 19.58 12.06 71 79421 73628 42468215
Product use in unapproved indication 19.54 12.06 235 79257 184221 42357622
Deja vu 19.53 12.06 5 79487 15 42541828
Diverticulitis 19.52 12.06 9 79483 22764 42519079
Transverse presentation 19.51 12.06 7 79485 80 42541763
Bladder cancer 19.51 12.06 4 79488 17043 42524800
Pneumonia bacterial 19.44 12.06 3 79489 15689 42526154
Benign cardiac neoplasm 19.32 12.06 6 79486 42 42541801
Prostatic specific antigen increased 19.31 12.06 4 79488 16921 42524922
Polydipsia 19.29 12.06 32 79460 4456 42537387
Maternal exposure before pregnancy 19.21 12.06 16 79476 1061 42540782
Pulmonary valve stenosis congenital 19.21 12.06 8 79484 140 42541703
Pyramidal tract syndrome 19.21 12.06 10 79482 296 42541547
Cheilitis 19.17 12.06 24 79468 2584 42539259
Localised infection 19.16 12.06 7 79485 20366 42521477
Hypothermia 19.06 12.06 59 79433 12456 42529387
Potter's syndrome 19.06 12.06 5 79487 17 42541826
Neurological decompensation 19.02 12.06 29 79463 3760 42538083
Accidental death 18.98 12.06 26 79466 3057 42538786
Cerebral haemorrhage 18.95 12.06 27 79465 38939 42502904
Skin malformation 18.91 12.06 4 79488 3 42541840
Coma scale abnormal 18.89 12.06 32 79460 4533 42537310
Skin degenerative disorder 18.84 12.06 5 79487 18 42541825
Blood urea increased 18.82 12.06 20 79472 32773 42509070
Vagal nerve stimulator implantation 18.77 12.06 7 79485 90 42541753
Skin erosion 18.74 12.06 25 79467 2866 42538977
Teratogenicity 18.74 12.06 6 79486 47 42541796
Neonatal disorder 18.73 12.06 14 79478 793 42541050
Temporal lobe epilepsy 18.71 12.06 9 79483 224 42541619
Joint laxity 18.70 12.06 11 79481 415 42541428
Adrenal insufficiency 18.67 12.06 6 79486 18918 42522925
Wrong product administered 18.67 12.06 38 79454 6188 42535655
Single umbilical artery 18.64 12.06 9 79483 226 42541617
Anaphylactic reaction 18.53 12.06 32 79460 42711 42499132
Idiopathic generalised epilepsy 18.52 12.06 6 79486 49 42541794
Blood pressure systolic increased 18.48 12.06 15 79477 27953 42513890
Hypokalaemia 18.46 12.06 70 79422 71651 42470192
Circulating anticoagulant 18.38 12.06 4 79488 4 42541839
Simple partial seizures 18.37 12.06 11 79481 429 42541414
Congenital eyelid malformation 18.36 12.06 7 79485 96 42541747
Hyperventilation 18.35 12.06 26 79466 3156 42538687
Hypoxic-ischaemic encephalopathy 18.34 12.06 34 79458 5168 42536675
Opsoclonus myoclonus 18.30 12.06 7 79485 97 42541746
Hepatocellular injury 18.25 12.06 90 79402 23588 42518255
Peritonitis 18.22 12.06 6 79486 18627 42523216
Developmental hip dysplasia 18.19 12.06 10 79482 331 42541512
Weight decrease neonatal 18.19 12.06 10 79482 331 42541512
Anticoagulation drug level abnormal 18.14 12.06 8 79484 162 42541681
Snoring 17.98 12.06 29 79463 3944 42537899
Oculomucocutaneous syndrome 17.96 12.06 8 79484 166 42541677
Neuralgia 17.91 12.06 13 79479 25634 42516209
Dyspepsia 17.88 12.06 31 79461 41321 42500522
Differential white blood cell count abnormal 17.79 12.06 19 79473 1725 42540118
Foetal macrosomia 17.70 12.06 8 79484 172 42541671
Fallot's tetralogy 17.66 12.06 8 79484 173 42541670
Hypermobility syndrome 17.60 12.06 10 79482 353 42541490
Tongue eruption 17.49 12.06 4 79488 6 42541837
Meningeal disorder 17.43 12.06 10 79482 360 42541483
Delusional perception 17.41 12.06 8 79484 179 42541664
Essential tremor 17.33 12.06 14 79478 889 42540954
Clostridium difficile colitis 17.30 12.06 9 79483 21243 42520600
Congenital astigmatism 17.27 12.06 6 79486 62 42541781
Asthma 17.24 12.06 59 79433 62255 42479588
Congenital cerebral cyst 17.20 12.06 5 79487 27 42541816
Cataract 17.19 12.06 19 79473 30585 42511258
Physical assault 17.11 12.06 15 79477 1067 42540776
Persistent depressive disorder 17.10 12.06 11 79481 488 42541355
Ear disorder 17.09 12.06 20 79472 2008 42539835
Hyperthermia 17.08 12.06 57 79435 12517 42529326
Tongue biting 17.05 12.06 15 79477 1072 42540771
Acute respiratory failure 16.92 12.06 29 79463 38829 42503014
Low set ears 16.90 12.06 11 79481 498 42541345
Urinary tract infection 16.89 12.06 112 79380 99172 42442671
Erythema 16.88 12.06 291 79201 108502 42433341
Myocardial ischaemia 16.88 12.06 6 79486 17756 42524087
Bezoar 16.87 12.06 16 79476 1260 42540583
Dermatitis allergic 16.83 12.06 44 79448 8439 42533404
Hypertrophic cardiomyopathy 16.81 12.06 17 79475 1448 42540395
Mental disability 16.77 12.06 6 79486 68 42541775
Positive end-expiratory pressure 16.77 12.06 4 79488 8 42541835
Cross sensitivity reaction 16.65 12.06 18 79474 1657 42540186
Muscle tone disorder 16.56 12.06 8 79484 201 42541642
Vesicoureteric reflux 16.56 12.06 8 79484 201 42541642
Newborn persistent pulmonary hypertension 16.53 12.06 7 79485 128 42541715
Automatism 16.48 12.06 7 79485 129 42541714
Dehydration 16.42 12.06 177 79315 141590 42400253
Pulmonary mass 16.33 12.06 5 79487 16260 42525583
Renal disorder 16.27 12.06 18 79474 28962 42512881
Haemodynamic instability 16.25 12.06 56 79436 12501 42529342
Eyelid oedema 16.18 12.06 34 79458 5661 42536182
Cardiac failure acute 16.02 12.06 3 79489 13630 42528213
Obesity 16 12.06 67 79425 16392 42525451
Cerebellar syndrome 15.98 12.06 23 79469 2832 42539011
Foetal distress syndrome 15.93 12.06 15 79477 1171 42540672
Cellulitis 15.92 12.06 60 79432 61525 42480318
Torticollis 15.91 12.06 16 79476 1354 42540489
Pulmonary alveolar haemorrhage 15.91 12.06 4 79488 14812 42527031
Rubella 15.86 12.06 3 79489 0 42541843
Metabolic myopathy 15.86 12.06 3 79489 0 42541843
Transient ischaemic attack 15.80 12.06 24 79468 33715 42508128
Hypervolaemia 15.78 12.06 12 79480 23113 42518730
Chordee 15.76 12.06 6 79486 82 42541761
Pleurothotonus 15.66 12.06 15 79477 1196 42540647
Congenital muscle absence 15.63 12.06 5 79487 39 42541804
Congenital vas deferens absence 15.63 12.06 5 79487 39 42541804
Monorchidism 15.62 12.06 4 79488 12 42541831
Subgaleal haematoma 15.56 12.06 6 79486 85 42541758
Product name confusion 15.44 12.06 6 79486 87 42541756
Dry skin 15.33 12.06 43 79449 48295 42493548
Extrapyramidal disorder 15.33 12.06 66 79426 16346 42525497
Neoplasm malignant 15.27 12.06 12 79480 22731 42519112
Product quality issue 15.26 12.06 70 79422 17812 42524031
Hypothermia neonatal 15.25 12.06 6 79486 90 42541753
Judgement impaired 15.21 12.06 11 79481 592 42541251
Congenital genital malformation 15.18 12.06 7 79485 158 42541685
Hallucination 15.12 12.06 169 79323 57338 42484505
Hyperammonaemic encephalopathy 15.12 12.06 22 79470 2736 42539107
Dysgraphia 15.09 12.06 21 79471 2507 42539336
Iron deficiency anaemia 15.04 12.06 3 79489 13036 42528807
Candida infection 15.03 12.06 11 79481 21599 42520244
Hyperphagia 14.97 12.06 17 79475 1653 42540190
Hypertelorism 14.95 12.06 11 79481 608 42541235
Hyperkinesia 14.94 12.06 19 79473 2079 42539764
Arthropod sting 14.86 12.06 10 79482 479 42541364
Hepatotoxicity 14.83 12.06 15 79477 25152 42516691
Nasal congestion 14.79 12.06 20 79472 29481 42512362
Conjunctival irritation 14.79 12.06 6 79486 98 42541745
Dermatitis exfoliative 14.79 12.06 37 79455 6910 42534933
Intraventricular haemorrhage neonatal 14.76 12.06 9 79483 363 42541480
Oesophagitis 14.75 12.06 5 79487 15242 42526601
Agoraphobia 14.68 12.06 8 79484 260 42541583
Abortion induced 14.67 12.06 7 79485 171 42541672
Limited symptom panic attack 14.63 12.06 5 79487 49 42541794
Mouth ulceration 14.62 12.06 61 79431 14902 42526941
Drug withdrawal syndrome 14.59 12.06 79 79413 21470 42520373
Shock haemorrhagic 14.58 12.06 6 79486 16236 42525607
Prominent epicanthal folds 14.56 12.06 7 79485 174 42541669
Madarosis 14.55 12.06 10 79482 496 42541347
Fontanelle bulging 14.54 12.06 4 79488 17 42541826
Postmature baby 14.54 12.06 4 79488 17 42541826
Device related infection 14.52 12.06 10 79482 20269 42521574
Congenital inguinal hernia 14.52 12.06 7 79485 175 42541668
Product administration interrupted 14.52 12.06 30 79462 4936 42536907
Neonatal respiratory distress 14.51 12.06 13 79479 952 42540891
Injection site pain 14.49 12.06 57 79435 57741 42484102
Gastric ulcer 14.48 12.06 8 79484 18254 42523589
Caudal regression syndrome 14.45 12.06 5 79487 51 42541792
International normalised ratio increased 14.44 12.06 44 79448 48124 42493719
Oral mucosal erythema 14.41 12.06 11 79481 643 42541200
Loss of employment 14.39 12.06 10 79482 505 42541338
Hypnagogic hallucination 14.36 12.06 5 79487 52 42541791
Learning disability 14.35 12.06 9 79483 382 42541461
Scab 14.33 12.06 33 79459 5845 42535998
Sweat gland disorder 14.30 12.06 6 79486 107 42541736
Full blood count abnormal 14.24 12.06 21 79471 29855 42511988
Tooth malformation 14.20 12.06 7 79485 184 42541659
Transient tachypnoea of the newborn 14.20 12.06 7 79485 184 42541659
Myositis 14.17 12.06 5 79487 14861 42526982
Acute coronary syndrome 14.16 12.06 5 79487 14860 42526983
Acute encephalitis with refractory, repetitive partial seizures 14.11 12.06 5 79487 55 42541788
Lip oedema 14.08 12.06 23 79469 3161 42538682
Activated partial thromboplastin time prolonged 14.08 12.06 6 79486 15897 42525946
Respiratory tract infection 14.07 12.06 17 79475 26305 42515538
Asterixis 14.04 12.06 15 79477 1362 42540481
Somnolence neonatal 14.02 12.06 4 79488 20 42541823
Nasal disorder 14.00 12.06 18 79474 1991 42539852
Osteoarthritis 13.87 12.06 15 79477 24390 42517453
Circadian rhythm sleep disorder 13.86 12.06 10 79482 536 42541307
Multiple organ dysfunction syndrome 13.86 12.06 115 79377 96920 42444923
Rash papular 13.85 12.06 51 79441 11760 42530083
Congenital spinal cord anomaly 13.79 12.06 3 79489 3 42541840
Decreased interest 13.76 12.06 21 79471 2724 42539119
Incorrect route of product administration 13.75 12.06 15 79477 24290 42517553
Congenital central nervous system anomaly 13.68 12.06 11 79481 694 42541149
Microphthalmos 13.67 12.06 7 79485 200 42541643
Thrombocytopenia neonatal 13.67 12.06 10 79482 548 42541295
Cholelithiasis 13.66 12.06 14 79478 23332 42518511
Febrile convulsion 13.63 12.06 11 79481 698 42541145
Rhinorrhoea 13.60 12.06 24 79468 31770 42510073
Rash macular 13.59 12.06 65 79427 16826 42525017
Congenital scoliosis 13.58 12.06 6 79486 122 42541721
Double outlet right ventricle 13.58 12.06 6 79486 122 42541721
Dysphoria 13.56 12.06 21 79471 2759 42539084
Congenital knee deformity 13.50 12.06 6 79486 124 42541719
Visual field defect 13.48 12.06 29 79463 4909 42536934
Heart disease congenital 13.47 12.06 15 79477 1427 42540416
Chorea 13.45 12.06 15 79477 1429 42540414
Papule 13.43 12.06 32 79460 5794 42536049
Sudden death 13.39 12.06 64 79428 16565 42525278
Pulmonary valve stenosis 13.38 12.06 9 79483 431 42541412
Hyperthyroidism 13.37 12.06 5 79487 14336 42527507
Exomphalos 13.36 12.06 7 79485 210 42541633
Skin warm 13.32 12.06 21 79471 2802 42539041
Genital erosion 13.29 12.06 8 79484 315 42541528
Renal tubular necrosis 13.21 12.06 9 79483 18345 42523498
Bone pain 13.11 12.06 15 79477 23777 42518066
Subacute cutaneous lupus erythematosus 13.09 12.06 15 79477 1473 42540370
Hospitalisation 13.07 12.06 83 79409 74247 42467596
Drug abuse 13.07 12.06 271 79221 104500 42437343
Moaning 13.07 12.06 12 79480 907 42540936
Crystal urine present 13.01 12.06 9 79483 451 42541392
Product administration error 12.93 12.06 68 79424 18275 42523568
Bruxism 12.92 12.06 18 79474 2151 42539692
Myelodysplastic syndrome 12.91 12.06 14 79478 22731 42519112
Generalised anxiety disorder 12.90 12.06 12 79480 922 42540921
Blood test abnormal 12.89 12.06 4 79488 12902 42528941
Congenital aortic atresia 12.88 12.06 4 79488 28 42541815
Stress 12.82 12.06 41 79451 44171 42497672
Meconium in amniotic fluid 12.76 12.06 4 79488 29 42541814
Ligament laxity 12.76 12.06 4 79488 29 42541814
Arteriosclerosis 12.71 12.06 9 79483 17980 42523863
Toxic skin eruption 12.66 12.06 55 79437 13675 42528168
Ventricular fibrillation 12.65 12.06 23 79469 30100 42511743
Strabismus congenital 12.64 12.06 4 79488 30 42541813
Peripheral artery thrombosis 12.64 12.06 20 79472 2677 42539166
Squamous cell carcinoma of skin 12.62 12.06 4 79488 12722 42529121
Aortic valve atresia 12.57 12.06 3 79489 6 42541837
Assisted delivery 12.57 12.06 3 79489 6 42541837
Small fontanelle 12.57 12.06 3 79489 6 42541837
Withdrawal catatonia 12.56 12.06 7 79485 238 42541605
Angina unstable 12.47 12.06 3 79489 11445 42530398
Presyncope 12.46 12.06 14 79478 22373 42519470
Wrist deformity 12.41 12.06 8 79484 356 42541487
Distributive shock 12.38 12.06 19 79473 2477 42539366
Economic problem 12.38 12.06 16 79476 1779 42540064
Retinogram abnormal 12.38 12.06 6 79486 152 42541691
Belligerence 12.38 12.06 6 79486 152 42541691
Live birth 12.38 12.06 7 79485 245 42541598
Euphoric mood 12.32 12.06 33 79459 6420 42535423
White blood cell count decreased 12.31 12.06 139 79353 110257 42431586
Hyperpyrexia 12.31 12.06 23 79469 3517 42538326
Congenital myopia 12.30 12.06 5 79487 82 42541761
Trichiasis 12.26 12.06 3 79489 7 42541836
Sleep-related eating disorder 12.25 12.06 8 79484 364 42541479
Viral rash 12.16 12.06 6 79486 158 42541685
Psoriasis 12.14 12.06 48 79444 48556 42493287

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Seizure 2855.21 10.66 2996 249542 218189 110118572
Drug reaction with eosinophilia and systemic symptoms 2628.85 10.66 1872 250666 80223 110256538
Completed suicide 2368.18 10.66 2840 249698 239541 110097220
Stevens-Johnson syndrome 1811.45 10.66 1201 251337 45700 110291061
Toxicity to various agents 1642.67 10.66 3478 249060 477077 109859684
Epilepsy 1286.30 10.66 1355 251183 98854 110237907
Intentional overdose 1261.74 10.66 1534 251004 130967 110205794
Generalised tonic-clonic seizure 1202.74 10.66 998 251540 53682 110283079
Suicide attempt 998.69 10.66 1206 251332 102188 110234573
Toxic epidermal necrolysis 887.18 10.66 854 251684 55873 110280888
Ataxia 819.47 10.66 623 251915 29485 110307276
Status epilepticus 771.73 10.66 613 251925 30958 110305803
Suicidal ideation 619.05 10.66 909 251629 93028 110243733
Overdose 583.23 10.66 1498 251040 232296 110104465
Somnolence 577.28 10.66 1739 250799 295710 110041051
Aggression 575.33 10.66 693 251845 58517 110278244
Exposure during pregnancy 552.78 10.66 1197 251341 166227 110170534
Drug interaction 543.17 10.66 2421 250117 497762 109838999
Multiple-drug resistance 513.33 10.66 340 252198 12895 110323866
Product substitution issue 498.78 10.66 417 252121 22644 110314117
Drug level increased 489.13 10.66 574 251964 47145 110289616
Intentional self-injury 481.45 10.66 507 252031 36922 110299839
Blepharospasm 467.21 10.66 601 251937 54250 110282511
Febrile neutropenia 459.31 10.66 84 252454 316683 110020078
Dyspnoea 458.53 10.66 1172 251366 1105700 109231061
Petit mal epilepsy 457.52 10.66 258 252280 7289 110329472
Anaemia 439.22 10.66 363 252175 546723 109790038
Coma 410.01 10.66 861 251677 117008 110219753
Agitation 407.52 10.66 838 251700 112213 110224548
Nystagmus 405.01 10.66 279 252259 11298 110325463
Diarrhoea 366.72 10.66 1354 251184 1138151 109198610
Mania 363.22 10.66 333 252205 20463 110316298
Depression 350.69 10.66 1545 250993 315790 110020971
Onychomadesis 349.78 10.66 475 252063 45188 110291573
Electrocardiogram QRS complex prolonged 346.70 10.66 266 252272 12755 110324006
Irritability 332.86 10.66 475 252063 47334 110289427
Sudden unexplained death in epilepsy 331.43 10.66 108 252430 715 110336046
Serotonin syndrome 321.73 10.66 524 252014 58629 110278132
Pneumonia 312.67 10.66 996 251542 875718 109461043
Taste disorder 307.66 10.66 543 251995 64844 110271917
Product quality issue 306.09 10.66 596 251942 76703 110260058
Acute kidney injury 306.08 10.66 619 251919 634811 109701950
Nail disorder 292.03 10.66 496 252042 57439 110279322
Disease progression 285.90 10.66 100 252438 243934 110092827
Rash maculo-papular 285.08 10.66 565 251973 73657 110263104
Focal dyscognitive seizures 281.56 10.66 149 252389 3700 110333061
Partial seizures 272.25 10.66 218 252320 11131 110325630
Cough 270.34 10.66 397 252141 461244 109875517
Atrial fibrillation 264.07 10.66 97 252441 229545 110107216
Memory impairment 263.20 10.66 1017 251521 195927 110140834
Breast cancer stage III 261.29 10.66 566 251972 78551 110258210
Back injury 252.51 10.66 416 252122 46983 110289778
Rash 252.17 10.66 2923 249615 818041 109518720
Back pain 251.24 10.66 286 252252 370710 109966051
Infection 251.00 10.66 274 252264 361926 109974835
Malignant neoplasm progression 247.16 10.66 49 252489 174518 110162243
Tremor 245.93 10.66 1014 251524 201218 110135543
Abnormal behaviour 237.39 10.66 364 252174 38675 110298086
Sinusitis 227.89 10.66 205 252333 296483 110040278
Live birth 227.07 10.66 495 252043 68989 110267772
Obsessive-compulsive disorder 222.00 10.66 161 252377 7080 110329681
Onychomycosis 218.62 10.66 348 252190 38183 110298578
Maternal exposure during pregnancy 210.37 10.66 1142 251396 253741 110083020
Cardiac failure congestive 208.36 10.66 45 252493 150955 110185806
Bipolar disorder 203.35 10.66 167 252371 8840 110327921
Diplopia 202.37 10.66 352 252186 41542 110295219
Anticonvulsant drug level decreased 200.92 10.66 98 252440 2038 110334723
Oral mucosa erosion 196.91 10.66 101 252437 2347 110334414
Chest pain 194.66 10.66 351 252187 376024 109960737
Neuropathy peripheral 194.15 10.66 83 252455 179194 110157567
Lymphadenopathy 193.13 10.66 441 252097 63394 110273367
Death 192.49 10.66 881 251657 697988 109638773
Pain 190.05 10.66 1339 251199 953616 109383145
Myocardial infarction 188.07 10.66 102 252436 191981 110144780
Myoclonus 185.80 10.66 297 252241 32701 110304060
Arthralgia 183.97 10.66 1037 251501 778595 109558166
Blood pressure increased 183.91 10.66 191 252347 258182 110078579
Brugada syndrome 183.62 10.66 84 252454 1504 110335257
Myoclonic epilepsy 182.33 10.66 99 252439 2592 110334169
Gastrointestinal haemorrhage 181.85 10.66 75 252463 165443 110171318
Haemophagocytic lymphohistiocytosis 180.38 10.66 286 252252 31273 110305488
Sepsis 178.64 10.66 295 252243 327051 110009710
Cardiac failure 177.42 10.66 104 252434 187522 110149239
Arthritis 176.10 10.66 81 252457 167505 110169256
Cardio-respiratory arrest 172.89 10.66 620 251918 115216 110221545
Adverse reaction 168.88 10.66 268 252270 29326 110307435
Drug eruption 168.23 10.66 376 252162 53283 110283478
Obesity 166.03 10.66 603 251935 112748 110224013
Lip erosion 164.76 10.66 82 252456 1784 110334977
Abortion spontaneous 164.22 10.66 287 252251 33995 110302766
Poisoning 163.92 10.66 262 252276 28843 110307918
Anticonvulsant drug level increased 163.28 10.66 94 252444 2764 110333997
Neuroleptic malignant syndrome 162.98 10.66 285 252253 33774 110302987
Oculogyric crisis 162.20 10.66 104 252434 3728 110333033
Haemoglobin decreased 161.60 10.66 198 252340 248529 110088232
Oedema peripheral 160.68 10.66 317 252221 328343 110008418
Migraine 160.18 10.66 796 251742 170856 110165905
Hyperkalaemia 158.38 10.66 56 252482 135740 110201021
Product label confusion 157.37 10.66 225 252313 22452 110314309
Facet joint syndrome 154.63 10.66 530 252008 96298 110240463
Suspected suicide 152.68 10.66 181 252357 15018 110321743
Neutropenia 152.57 10.66 399 252139 374221 109962540
Anticonvulsant drug level above therapeutic 149.84 10.66 68 252470 1194 110335567
Psychotic disorder 149.79 10.66 348 252190 50589 110286172
Tardive dyskinesia 148.61 10.66 169 252369 13410 110323351
Confusional state 147.14 10.66 1677 250861 467003 109869758
Wound infection 146.24 10.66 519 252019 95946 110240815
Fatigue 145.75 10.66 1931 250607 1214027 109122734
Hypercholesterolaemia 144.87 10.66 497 252041 90340 110246421
Chronic obstructive pulmonary disease 141.78 10.66 37 252501 109121 110227640
Foetal exposure during pregnancy 140.54 10.66 125 252413 7380 110329381
Erythema multiforme 138.65 10.66 204 252334 20893 110315868
Asthma 137.97 10.66 224 252314 250067 110086694
Disturbance in attention 136.89 10.66 380 252158 61615 110275146
Electroencephalogram abnormal 136.32 10.66 113 252425 6060 110330701
Rash morbilliform 136.27 10.66 126 252412 7825 110328936
Psychomotor hyperactivity 136.05 10.66 198 252340 20079 110316682
COVID-19 135.38 10.66 219 252319 244841 110091920
Peripheral venous disease 134.81 10.66 461 252077 83656 110253105
Cognitive disorder 134.52 10.66 473 252065 87038 110249723
Dehydration 131.15 10.66 276 252262 279235 110057526
Cerebrovascular accident 130.12 10.66 133 252405 181151 110155610
Hyperreflexia 130.07 10.66 133 252405 9352 110327409
Dyspnoea exertional 130.05 10.66 38 252500 104022 110232739
Cytokine release syndrome 128.60 10.66 8 252530 70298 110266463
Aura 128.53 10.66 59 252479 1065 110335696
Behaviour disorder 128.18 10.66 133 252405 9514 110327247
Renal impairment 127.76 10.66 145 252393 188300 110148461
Conjunctival hyperaemia 127.23 10.66 106 252432 5725 110331036
Pain in extremity 125.23 10.66 629 251909 486489 109850272
Extrapyramidal disorder 124.64 10.66 231 252307 28636 110308125
Partial seizures with secondary generalisation 123.68 10.66 53 252485 806 110335955
Constipation 123.28 10.66 412 252126 357374 109979387
Haematochezia 122.66 10.66 55 252483 115469 110221292
Gastrooesophageal reflux disease 120.92 10.66 764 251774 179212 110157549
Herpes zoster 120.84 10.66 48 252490 108331 110228430
Akathisia 120.52 10.66 171 252367 16942 110319819
Productive cough 120.46 10.66 55 252483 114250 110222511
Poisoning deliberate 120.40 10.66 216 252322 26115 110310646
Ascites 119.50 10.66 32 252506 92776 110243985
Weight decreased 117.69 10.66 609 251929 467448 109869313
Hallucination, auditory 117.46 10.66 214 252324 26183 110310578
Pulmonary embolism 117.21 10.66 193 252345 214281 110122480
Pleural effusion 116.96 10.66 140 252398 177569 110159192
Bursitis 116.62 10.66 596 251942 129322 110207439
Interstitial lung disease 114.63 10.66 90 252448 139244 110197517
Mydriasis 113.36 10.66 191 252347 21966 110314795
Platelet count decreased 111.95 10.66 223 252315 230220 110106541
Blood pressure systolic increased 111.92 10.66 26 252512 82965 110253796
Bipolar I disorder 111.86 10.66 68 252470 2215 110334546
Accidental exposure to product by child 111.69 10.66 77 252461 3121 110333640
Altered state of consciousness 111.58 10.66 337 252201 57289 110279472
Rheumatoid factor positive 109.60 10.66 84 252454 131556 110205205
Finger deformity 109.52 10.66 237 252301 32855 110303906
Pleurothotonus 108.72 10.66 69 252469 2429 110334332
Atonic seizures 108.71 10.66 53 252485 1101 110335660
Electrocardiogram QT prolonged 107.14 10.66 513 252025 108447 110228314
Rectal haemorrhage 106.94 10.66 71 252467 119762 110216999
Dyskinesia 106.41 10.66 308 252230 51138 110285623
Mood altered 106.37 10.66 182 252356 21193 110315568
Depressed level of consciousness 106.36 10.66 523 252015 111755 110225006
Coronary artery disease 106.01 10.66 18 252520 71672 110265089
Sleep disorder due to general medical condition, insomnia type 105.00 10.66 55 252483 105588 110231173
Lip dry 104.11 10.66 479 252059 99604 110237157
Delusion 103.70 10.66 191 252347 23564 110313197
Abdominal pain 103.36 10.66 716 251822 512273 109824488
Hypomania 103.23 10.66 122 252416 10088 110326673
Face oedema 103.20 10.66 233 252305 33236 110303525
Clonus 101.41 10.66 112 252426 8604 110328157
Type 2 diabetes mellitus 100.83 10.66 722 251816 176510 110160251
Depressed mood 100.73 10.66 337 252201 60472 110276289
Colitis 100.62 10.66 54 252484 102269 110234492
Tonic convulsion 100.32 10.66 71 252467 3003 110333758
Urinary tract infection 99.02 10.66 396 252142 325886 110010875
Drug-induced liver injury 98.97 10.66 538 252000 119529 110217232
Renal failure 98.68 10.66 233 252305 226341 110110420
Dissociation 98.52 10.66 117 252421 9725 110327036
Sedation 97.23 10.66 365 252173 69318 110267443
Myelosuppression 96.93 10.66 47 252491 94293 110242468
Haemoptysis 96.93 10.66 22 252516 71332 110265429
Deep vein thrombosis 95.50 10.66 107 252431 139780 110196981
Apathy 95.34 10.66 149 252389 16090 110320671
Sopor 94.92 10.66 238 252300 36308 110300453
Chest discomfort 94.46 10.66 157 252381 173691 110163070
Blister 94.42 10.66 862 251676 226514 110110247
Blood creatinine increased 94.07 10.66 171 252367 182718 110154043
Muscle rigidity 93.52 10.66 184 252354 23847 110312914
Anxiety 93.45 10.66 1201 251337 343877 109992884
Bronchitis 92.79 10.66 134 252404 156898 110179863
Plasma cell myeloma 92.63 10.66 16 252522 62920 110273841
Influenza 92.54 10.66 152 252386 168949 110167812
Maternal exposure during breast feeding 92.38 10.66 77 252461 4161 110332600
Dizziness 92.08 10.66 2164 250374 696029 109640732
Wrong patient received product 90.46 10.66 93 252445 6581 110330180
Thinking abnormal 90.39 10.66 140 252398 15000 110321761
Infusion site reaction 89.89 10.66 152 252386 17530 110319231
Abortion induced 89.79 10.66 101 252437 7918 110328843
Anger 89.57 10.66 158 252380 18849 110317912
Cardiac arrest 89.50 10.66 761 251777 195992 110140769
Vertigo 89.05 10.66 414 252124 86456 110250305
Thrombosis 88.36 10.66 71 252467 108591 110228170
Suicidal behaviour 87.79 10.66 69 252469 3428 110333333
Joint swelling 87.75 10.66 621 251917 442224 109894537
Neoplasm progression 87.58 10.66 20 252518 64575 110272186
Drug level decreased 87.17 10.66 154 252384 18394 110318367
Blood pressure fluctuation 86.99 10.66 31 252507 74793 110261968
Meningitis aseptic 86.93 10.66 110 252428 9760 110327001
Respiratory arrest 86.92 10.66 312 252226 57987 110278774
Eosinophilic myocarditis 86.80 10.66 56 252482 2029 110334732
Hyperthermia 86.59 10.66 166 252372 21106 110315655
Dystonia 85.61 10.66 185 252353 25620 110311141
Heart rate decreased 85.37 10.66 41 252497 82715 110254046
Psychomotor retardation 85.31 10.66 97 252441 7695 110329066
Bezoar 84.95 10.66 72 252466 3982 110332779
Malaise 82.71 10.66 1060 251478 670759 109666002
Treatment noncompliance 82.43 10.66 358 252180 72632 110264129
Injection site pain 82.33 10.66 177 252361 177745 110159016
Acute myocardial infarction 81.23 10.66 45 252493 83732 110253029
Coeliac disease 81.21 10.66 250 252288 42937 110293824
Cellulitis 81.09 10.66 101 252437 125915 110210846
Liver function test increased 80.70 10.66 408 252130 88140 110248621
Neovascularisation 80.68 10.66 50 252488 1687 110335074
Hypoxia 80.04 10.66 107 252431 129408 110207353
Infarction 79.83 10.66 78 252460 5191 110331570
Toxic skin eruption 79.81 10.66 187 252351 27328 110309433
Nasal congestion 78.94 10.66 65 252473 98217 110238544
Postictal psychosis 78.76 10.66 28 252510 249 110336512
Balance disorder 77.76 10.66 494 252044 116066 110220695
Dysarthria 77.65 10.66 389 252149 83732 110253029
Eyelid erosion 77.62 10.66 20 252518 47 110336714
C-reactive protein increased 77.61 10.66 800 251738 217119 110119642
Melaena 77.39 10.66 30 252508 68727 110268034
Hypomagnesaemia 77.37 10.66 21 252517 60349 110276412
Neck pain 77.35 10.66 514 252024 122616 110214145
Septic shock 76.87 10.66 152 252386 157376 110179385
Gaze palsy 76.56 10.66 63 252475 3344 110333417
Cross sensitivity reaction 76.22 10.66 78 252460 5489 110331272
Nausea 76.21 10.66 2195 250343 1233495 109103266
Hallucination, visual 76.09 10.66 231 252307 39374 110297387
Mucosal inflammation 75.48 10.66 65 252473 96076 110240685
Colitis ulcerative 74.36 10.66 42 252496 77321 110259440
Oedema 74.20 10.66 239 252299 209737 110127024
Acute myeloid leukaemia 73.94 10.66 3 252535 38107 110298654
Camptocormia 73.21 10.66 31 252507 457 110336304
Oxygen saturation decreased 72.77 10.66 156 252382 156826 110179935
Fluid retention 72.54 10.66 65 252473 94242 110242519
Epistaxis 72.44 10.66 116 252422 130256 110206505
SJS-TEN overlap 72.32 10.66 48 252490 1826 110334935
Tubulointerstitial nephritis and uveitis syndrome 71.78 10.66 29 252509 377 110336384
Thrombocytopenia 71.67 10.66 484 252054 348401 109988360
Antipsychotic drug level increased 71.22 10.66 84 252454 6931 110329830
White blood cell count decreased 71.10 10.66 276 252262 229114 110107647
Drug resistance 71.08 10.66 286 252252 56088 110280673
Pulmonary oedema 70.91 10.66 75 252463 100584 110236177
Cytomegalovirus infection 69.66 10.66 19 252519 54425 110282336
Catatonia 69.58 10.66 106 252432 11194 110325567
Mood swings 69.43 10.66 158 252380 22654 110314107
Mental impairment 69.12 10.66 157 252381 22482 110314279
Epileptic aura 68.96 10.66 19 252519 63 110336698
Mental disorder 68.75 10.66 220 252318 38571 110298190
Cerebellar syndrome 68.23 10.66 78 252460 6224 110330537
Normal newborn 68.14 10.66 153 252385 21743 110315018
Diverticulitis 67.88 10.66 19 252519 53503 110283258
Developmental delay 67.61 10.66 42 252496 1423 110335338
Restlessness 67.44 10.66 281 252257 55978 110280783
Decreased appetite 67.30 10.66 728 251810 475118 109861643
Depressive symptom 66.66 10.66 89 252449 8325 110328436
Haematuria 66.53 10.66 55 252483 82950 110253811
Ischaemic stroke 66.51 10.66 8 252530 41255 110295506
Cheilitis 65.92 10.66 77 252461 6288 110330473
Liver injury 65.89 10.66 577 251961 149836 110186925
Cataract 65.80 10.66 51 252487 79434 110257327
Parkinsonism 65.68 10.66 152 252386 22035 110314726
Impulsive behaviour 65.65 10.66 57 252481 3258 110333503
Blood prolactin increased 65.31 10.66 66 252472 4576 110332185
Inappropriate schedule of product administration 65.06 10.66 242 252296 203395 110133366
Metastases to liver 64.80 10.66 4 252534 35382 110301379
Cerebral infarction 64.64 10.66 19 252519 51819 110284942
Hepatitis 64.04 10.66 388 252150 89666 110247095
Unresponsive to stimuli 63.90 10.66 302 252236 63488 110273273
Learning disorder 63.32 10.66 32 252506 720 110336041
Psychiatric symptom 63.32 10.66 91 252447 9122 110327639
Cystitis 63.26 10.66 36 252502 66000 110270761
Tic 63.08 10.66 57 252481 3436 110333325
Encephalopathy 62.66 10.66 357 252181 80698 110256063
Pneumocystis jirovecii pneumonia 62.59 10.66 11 252527 42724 110294037
Trichiasis 62.22 10.66 20 252518 126 110336635
Night sweats 61.85 10.66 520 252018 133463 110203298
Bronchiectasis 61.56 10.66 6 252532 36487 110300274
Upper gastrointestinal haemorrhage 61.31 10.66 19 252519 50077 110286684
Syncope 61.29 10.66 246 252292 202290 110134471
Myalgia 61.23 10.66 280 252258 222101 110114660
Lactic acidosis 61.17 10.66 73 252465 92738 110244023
Injection site erythema 61.09 10.66 75 252463 94101 110242660
Pulmonary hypertension 60.66 10.66 25 252513 55195 110281566
Exposure via ingestion 60.56 10.66 65 252473 4835 110331926
Major depression 60.34 10.66 96 252442 10525 110326236
Oscillopsia 60.05 10.66 26 252512 406 110336355
Angina pectoris 59.62 10.66 34 252504 62261 110274500
Pancytopenia 59.47 10.66 261 252277 209352 110127409
Gout 59.16 10.66 7 252531 36559 110300202
Hypogammaglobulinaemia 58.84 10.66 137 252401 19939 110316822
Crying 58.46 10.66 159 252379 25469 110311292
Pruritus 58.41 10.66 955 251583 580605 109756156
Pulmonary fibrosis 58.40 10.66 89 252449 101953 110234808
Conjunctivitis 58.39 10.66 190 252348 33602 110303159
Eosinophilia 57.83 10.66 274 252264 57662 110279099
Withdrawal syndrome 57.47 10.66 180 252358 31200 110305561
Pneumonitis 57.37 10.66 54 252484 76477 110260284
Osteonecrosis of jaw 57.36 10.66 19 252519 47998 110288763
Sleep disorder 56.98 10.66 699 251839 197945 110138816
Joint range of motion decreased 56.85 10.66 474 252064 121358 110215403
Dysmetria 56.83 10.66 37 252501 1362 110335399
Salivary hypersecretion 56.77 10.66 124 252414 17297 110319464
Temporal lobe epilepsy 56.51 10.66 26 252512 472 110336289
Pain in jaw 56.50 10.66 23 252515 51154 110285607
Skin ulcer 56.38 10.66 38 252500 63607 110273154
Grip strength decreased 56.10 10.66 344 252194 79830 110256931
Hyperglycaemia 56.00 10.66 67 252471 85023 110251738
Lung neoplasm malignant 55.96 10.66 6 252532 33836 110302925
Overlap syndrome 55.81 10.66 85 252453 8974 110327787
Palmar-plantar erythrodysaesthesia syndrome 55.02 10.66 13 252525 41012 110295749
Retinal pigment epitheliopathy 54.96 10.66 26 252512 504 110336257
Haemorrhoids 54.91 10.66 8 252530 35664 110301097
Hepatotoxicity 54.65 10.66 39 252499 63361 110273400
Change in seizure presentation 54.62 10.66 30 252508 804 110335957
Psychotic symptom 54.44 10.66 55 252483 3812 110332949
Palpitations 54.32 10.66 184 252354 159028 110177733
Coma scale abnormal 54.01 10.66 87 252451 9639 110327122
Postictal paralysis 53.98 10.66 27 252511 594 110336167
Blood glucose increased 53.96 10.66 141 252397 132355 110204406
Simple partial seizures 53.72 10.66 32 252506 1004 110335757
Euphoric mood 53.22 10.66 82 252456 8745 110328016
Loss of consciousness 52.99 10.66 683 251855 195623 110141138
Anticonvulsant drug level below therapeutic 52.84 10.66 33 252505 1129 110335632
Hostility 52.67 10.66 46 252492 2650 110334111
Rash macular 52.61 10.66 201 252337 38485 110298276
Paroxysmal perceptual alteration 52.25 10.66 21 252517 269 110336492
Speech disorder developmental 51.90 10.66 30 252508 889 110335872
Hypokalaemia 51.86 10.66 227 252311 182221 110154540
Upper respiratory tract infection 51.79 10.66 142 252396 131186 110205575
Respiratory failure 51.36 10.66 285 252253 215047 110121714
Chronic kidney disease 51.36 10.66 59 252479 76232 110260529
Enanthema 51.05 10.66 32 252506 1102 110335659
Respiratory tract infection 50.85 10.66 53 252485 71564 110265197
Sinus tachycardia 50.82 10.66 219 252319 44274 110292487
Paradoxical drug reaction 50.71 10.66 85 252453 9732 110327029
Sciatica 50.59 10.66 83 252455 92316 110244445
Hypertonia 50.56 10.66 78 252460 8328 110328433
Muscle twitching 50.55 10.66 167 252371 29768 110306993
Prostate cancer 50.34 10.66 12 252526 37629 110299132
Drug abuse 49.90 10.66 622 251916 176789 110159972
Intellectual disability 49.58 10.66 39 252499 1940 110334821
Contusion 49.28 10.66 321 252217 233040 110103721
Fibromyalgia 49.27 10.66 602 251936 170307 110166454
Drug titration error 49.08 10.66 36 252502 1611 110335150
Femur fracture 49.07 10.66 20 252518 44449 110292312
Libido increased 48.96 10.66 43 252495 2496 110334265
Exposure via breast milk 48.78 10.66 30 252508 998 110335763
Hypotension 48.77 10.66 872 251666 522977 109813784
Affective disorder 48.58 10.66 90 252448 11151 110325610
Mucosal disorder 48.38 10.66 55 252483 4362 110332399
Logorrhoea 48.09 10.66 58 252480 4899 110331862
Drug screen false positive 47.90 10.66 33 252505 1336 110335425
Inflammation 47.88 10.66 662 251876 192576 110144185
Injection site reaction 47.85 10.66 358 252180 88712 110248049
Pulmonary mass 47.75 10.66 13 252525 37288 110299473
Basal cell carcinoma 47.35 10.66 22 252516 45248 110291513
Blood pressure diastolic abnormal 47.02 10.66 3 252535 25812 110310949
Haemorrhage 47.00 10.66 109 252429 106583 110230178
Oral disorder 46.82 10.66 92 252446 11911 110324850
Speech disorder 46.81 10.66 270 252268 61299 110275462
Abulia 46.77 10.66 32 252506 1281 110335480
Dysphonia 46.63 10.66 63 252475 75866 110260895
Device related infection 46.58 10.66 16 252522 39503 110297258
Pulmonary arterial hypertension 46.37 10.66 9 252529 32559 110304202
Paranoia 46.31 10.66 134 252404 22240 110314521
Distributive shock 46.08 10.66 62 252476 5842 110330919
Neutrophil count decreased 46.04 10.66 133 252405 120808 110215953
Dry skin 45.82 10.66 112 252426 107541 110229220
Gastric ulcer 45.45 10.66 17 252521 39810 110296951
Full blood count decreased 45.43 10.66 9 252529 32090 110304671
Anaphylactic shock 45.36 10.66 31 252507 51515 110285246
Cardiac disorder 45.14 10.66 65 252473 76215 110260546
Discomfort 45.00 10.66 296 252242 214411 110122350
Localised infection 44.90 10.66 21 252517 43027 110293734
Protothecosis 44.86 10.66 23 252515 534 110336227
Dry mouth 44.78 10.66 673 251865 199275 110137486
Underdose 44.66 10.66 273 252265 63281 110273480
Overweight 44.65 10.66 64 252474 6400 110330361
Distractibility 44.57 10.66 27 252511 874 110335887
Oculomucocutaneous syndrome 44.55 10.66 20 252518 342 110336419
Hypervolaemia 44.53 10.66 29 252509 49431 110287330
Peritonitis 44.39 10.66 10 252528 32597 110304164
Drug withdrawal convulsions 44.29 10.66 40 252498 2409 110334352
Sinus congestion 44.26 10.66 8 252530 30451 110306310
Skin degenerative disorder 44.23 10.66 11 252527 21 110336740
Gambling disorder 44.05 10.66 38 252500 2153 110334608
Chills 43.96 10.66 255 252283 190325 110146436
Seizure cluster 43.90 10.66 26 252512 807 110335954
Hypercalcaemia 43.89 10.66 26 252512 46631 110290130
Full blood count abnormal 43.87 10.66 38 252500 56014 110280747
Rash papular 43.85 10.66 151 252387 27488 110309273
Thrombotic microangiopathy 43.81 10.66 7 252531 29142 110307619
Disorientation 43.76 10.66 294 252244 70377 110266384
Psoriasis 43.64 10.66 168 252370 139825 110196936
Papule 43.63 10.66 81 252457 10052 110326709
Hypophosphataemia 43.55 10.66 11 252527 33171 110303590
Rhinorrhoea 43.55 10.66 107 252431 102559 110234202
Psychogenic seizure 43.52 10.66 39 252499 2325 110334436
Pregnancy with implant contraceptive 43.41 10.66 39 252499 2333 110334428
Osteoarthritis 43.38 10.66 621 251917 182002 110154759
Anaphylactic reaction 43.28 10.66 126 252412 114174 110222587
Blood pressure diastolic decreased 43.22 10.66 14 252524 35871 110300890
Bone pain 43.17 10.66 51 252487 65082 110271679
Hepatic enzyme 43.05 10.66 56 252482 5107 110331654
Folliculitis 43.02 10.66 578 251960 167075 110169686
Hypersensitivity 43.01 10.66 656 251882 403342 109933419
Drug dose titration not performed 42.85 10.66 28 252510 1037 110335724
Illusion 42.79 10.66 36 252502 1971 110334790
Postictal state 42.38 10.66 39 252499 2407 110334354
Staring 42.31 10.66 42 252496 2850 110333911
Throat irritation 42.28 10.66 36 252502 53516 110283245
Adrenal insufficiency 42.22 10.66 22 252516 42368 110294393
COVID-19 pneumonia 42.14 10.66 16 252522 37127 110299634
Rash erythematous 41.77 10.66 325 252213 81507 110255254
Clostridium difficile colitis 41.74 10.66 24 252514 43754 110293007
Tachyphrenia 41.67 10.66 38 252500 2318 110334443
Psoriatic arthropathy 41.65 10.66 656 251882 196105 110140656
Posture abnormal 41.55 10.66 51 252487 4387 110332374
Inappropriate affect 41.53 10.66 33 252505 1666 110335095
Caesarean section 41.27 10.66 95 252443 13722 110323039
Nasopharyngitis 41.08 10.66 643 251895 393718 109943043
Metastases to lung 41.08 10.66 3 252535 23060 110313701
Dysmorphism 41.06 10.66 23 252515 641 110336120
Muscle injury 41.03 10.66 497 252041 140310 110196451
Bronchopulmonary aspergillosis 40.98 10.66 9 252529 29854 110306907
Transfusion 40.90 10.66 5 252533 25467 110311294
Excessive eye blinking 40.81 10.66 34 252504 1836 110334925
Swollen joint count increased 40.57 10.66 81 252457 83580 110253181
Haematemesis 40.56 10.66 45 252493 59063 110277698
Cataplexy 40.48 10.66 28 252510 1141 110335620
Gait inability 40.45 10.66 483 252055 135893 110200868
Blood test abnormal 40.43 10.66 8 252530 28546 110308215
Transient ischaemic attack 40.40 10.66 52 252486 63930 110272831
Hypocalcaemia 40.38 10.66 54 252484 65312 110271449
Feeling drunk 40.28 10.66 56 252482 5444 110331317
Obsessive thoughts 39.93 10.66 29 252509 1278 110335483
Heart rate increased 39.64 10.66 181 252357 143653 110193108
Cerebral atrophy 39.59 10.66 73 252465 9012 110327749
Educational problem 39.48 10.66 21 252517 527 110336234
Cerebellar atrophy 39.37 10.66 30 252508 1423 110335338
Wrong schedule 39.33 10.66 23 252515 697 110336064
Pseudolymphoma 39.09 10.66 28 252510 1207 110335554
Fungal infection 39.09 10.66 35 252503 50771 110285990
Psychomotor skills impaired 39.01 10.66 63 252475 6995 110329766
Cerebral haemorrhage 38.80 10.66 55 252483 64913 110271848
Oesophagitis 38.71 10.66 9 252529 28706 110308055
Peripheral swelling 38.39 10.66 670 251868 403364 109933397
Cerebral salt-wasting syndrome 38.34 10.66 17 252521 282 110336479
Unintended pregnancy 38.31 10.66 51 252487 4757 110332004
Nephropathy toxic 38.28 10.66 8 252530 27470 110309291
Gestational diabetes 38.20 10.66 64 252474 7325 110329436
Lip ulceration 38.17 10.66 39 252499 2739 110334022
Hypocholesterolaemia 37.81 10.66 59 252479 6362 110330399
Foot deformity 37.78 10.66 33 252505 48447 110288314
Chronic sinusitis 37.75 10.66 6 252532 25078 110311683
Clostridium difficile infection 37.66 10.66 38 252500 52091 110284670
Therapeutic response unexpected 37.60 10.66 130 252408 23713 110313048
Hallucination 37.34 10.66 375 252163 101057 110235704
Right ventricular failure 37.32 10.66 7 252531 25947 110310814
Retinogram abnormal 37.18 10.66 18 252520 368 110336393
Nodule 37.12 10.66 14 252524 32617 110304144
Epidermolysis bullosa 36.96 10.66 18 252520 373 110336388
Haematotoxicity 36.82 10.66 3 252535 21079 110315682
Bone marrow failure 36.54 10.66 47 252491 57801 110278960
Osteomyelitis 36.44 10.66 19 252519 36581 110300180
Pregnancy on oral contraceptive 36.37 10.66 24 252514 904 110335857
Increased appetite 36.26 10.66 95 252443 14882 110321879
Persecutory delusion 35.93 10.66 57 252481 6234 110330527
Hypoglycaemia 35.76 10.66 140 252398 115964 110220797
Suicide threat 35.65 10.66 12 252526 89 110336672
Cholelithiasis 35.63 10.66 56 252482 63366 110273395
Flatulence 35.46 10.66 40 252498 52109 110284652
Ejection fraction decreased 35.42 10.66 25 252513 40855 110295906
Blood urea increased 35.40 10.66 44 252494 54913 110281848
Feelings of worthlessness 35.30 10.66 20 252518 570 110336191
Injection site bruising 35.21 10.66 39 252499 51224 110285537
Soft tissue injury 35.06 10.66 34 252504 2242 110334519
Mental status changes 34.88 10.66 295 252243 75827 110260934
Blood cholesterol increased 34.66 10.66 604 251934 184181 110152580
Tonic clonic movements 34.46 10.66 38 252500 2914 110333847
Therapeutic response changed 34.45 10.66 29 252509 1589 110335172
Cytopenia 34.12 10.66 13 252525 30103 110306658
Learning disability 33.91 10.66 14 252524 193 110336568
Polyhydramnios 33.84 10.66 31 252507 1902 110334859
Myelodysplastic syndrome 33.72 10.66 22 252516 37462 110299299
Blood potassium increased 33.49 10.66 17 252521 33232 110303529
Pericarditis 33.47 10.66 694 251844 218420 110118341
Road traffic accident 33.40 10.66 129 252409 107269 110229492
Irregular sleep phase 33.33 10.66 13 252525 153 110336608
Drooling 33.19 10.66 59 252479 7080 110329681
Neoplasm malignant 33.14 10.66 22 252516 37121 110299640
Intermenstrual bleeding 33.14 10.66 58 252480 6876 110329885
Negative symptoms in schizophrenia 33.09 10.66 14 252524 206 110336555
Blood pressure systolic abnormal 33.08 10.66 8 252530 24842 110311919
Illness 33.03 10.66 88 252450 82083 110254678
Product dispensing error 32.97 10.66 97 252441 16248 110320513
Aspergillus infection 32.66 10.66 9 252529 25607 110311154
Ureteric perforation 32.61 10.66 8 252530 14 110336747
Hip arthroplasty 32.59 10.66 48 252490 55765 110280996
Persistent depressive disorder 32.54 10.66 27 252511 1450 110335311
Maternal exposure before pregnancy 32.45 10.66 59 252479 7206 110329555
Heart rate irregular 32.38 10.66 19 252519 34255 110302506
Osteoporosis 32.33 10.66 97 252441 87055 110249706
Knee arthroplasty 32.25 10.66 62 252476 64886 110271875
Breath sounds abnormal 32.25 10.66 9 252529 25395 110311366
Angiofibroma 32.08 10.66 12 252526 125 110336636
Blood pressure diastolic increased 31.97 10.66 3 252535 18804 110317957
Infusion related reaction 31.90 10.66 646 251892 380516 109956245
Bundle branch block right 31.87 10.66 80 252458 12211 110324550
Pharyngeal erythema 31.85 10.66 32 252506 2203 110334558
Vulvar erosion 31.77 10.66 13 252525 175 110336586
Epidermal necrosis 31.76 10.66 37 252501 3013 110333748
Presyncope 31.63 10.66 39 252499 48848 110287913
Cardiac failure acute 31.57 10.66 8 252530 24070 110312691
Injection site swelling 31.55 10.66 58 252480 61732 110275029
Benzodiazepine drug level increased 31.47 10.66 14 252524 234 110336527
Orthostatic hypotension 31.39 10.66 65 252473 66184 110270577
Vagal nerve stimulator implantation 31.37 10.66 14 252524 236 110336525
Corneal reflex decreased 31.09 10.66 18 252520 535 110336226
Metastases to central nervous system 31.06 10.66 7 252531 22810 110313951
Immunodeficiency 30.79 10.66 26 252512 38812 110297949
Acute respiratory failure 30.71 10.66 80 252458 75180 110261581
Drug clearance increased 30.65 10.66 16 252522 386 110336375
Frequent bowel movements 30.59 10.66 74 252464 71316 110265445
Flat affect 30.55 10.66 33 252505 2472 110334289
Premature baby 30.54 10.66 46 252492 4809 110331952
Attention deficit hyperactivity disorder 30.34 10.66 44 252494 4447 110332314
Bladder cancer 30.21 10.66 5 252533 20287 110316474
Galactorrhoea 29.97 10.66 42 252496 4113 110332648
Human herpesvirus 6 infection reactivation 29.91 10.66 23 252515 1106 110335655
Traumatic coma 29.73 10.66 10 252528 74 110336687
Dysphoria 29.73 10.66 53 252485 6375 110330386
Multiple congenital abnormalities 29.71 10.66 11 252527 111 110336650
Placental disorder 29.71 10.66 22 252516 999 110335762
Post-traumatic neck syndrome 29.59 10.66 33 252505 2562 110334199
Hiatus hernia 29.52 10.66 13 252525 27593 110309168
Hot flush 29.46 10.66 67 252471 65969 110270792
Automatism 29.41 10.66 13 252525 214 110336547
Loss of personal independence in daily activities 29.35 10.66 211 252327 149809 110186952
Sleep-related eating disorder 29.35 10.66 21 252517 904 110335857
Sternal fracture 29.27 10.66 37 252501 3279 110333482
Blood creatine phosphokinase increased 29.27 10.66 275 252263 72802 110263959
Duodenal ulcer perforation 29.19 10.66 569 251969 177131 110159630
Vanishing bile duct syndrome 29.00 10.66 36 252502 3132 110333629
Lymphocyte count decreased 28.99 10.66 54 252484 57189 110279572
Lymphangioleiomyomatosis 28.97 10.66 13 252525 222 110336539
Off label use 28.94 10.66 2993 249545 1497192 108839569
Hyperprolactinaemia 28.87 10.66 53 252485 6522 110330239
Lower gastrointestinal haemorrhage 28.79 10.66 4 252534 18482 110318279
Red blood cell sedimentation rate abnormal 28.75 10.66 10 252528 24499 110312262
Giant cell myocarditis 28.66 10.66 9 252529 52 110336709
International normalised ratio increased 28.44 10.66 102 252436 86670 110250091
Sinus disorder 28.38 10.66 20 252518 32708 110304053
Liver disorder 28.35 10.66 199 252339 142044 110194717
Tendonitis 28.34 10.66 12 252526 26071 110310690
Glossodynia 28.20 10.66 685 251853 221319 110115442
Procedural pain 27.96 10.66 24 252514 35541 110301220
Lower limb fracture 27.85 10.66 84 252454 75264 110261497
Gastritis 27.78 10.66 50 252488 53649 110283112
Persistent genital arousal disorder 27.76 10.66 18 252520 658 110336103
Angioedema 27.71 10.66 123 252415 98377 110238384
Spinal stenosis 27.70 10.66 5 252533 19051 110317710
Paraesthesia 27.64 10.66 827 251711 275694 110061067
Oral herpes 27.58 10.66 25 252513 36055 110300706
Arteriosclerosis 27.55 10.66 11 252527 24756 110312005
Peripheral sensory neuropathy 27.47 10.66 3 252535 16677 110320084
Bacterial infection 27.46 10.66 39 252499 45997 110290764
Shock haemorrhagic 27.34 10.66 14 252524 27233 110309528
Pulmonary toxicity 27.26 10.66 4 252534 17742 110319019
Pemphigus 27.23 10.66 662 251876 213908 110122853
Blood bilirubin increased 27.15 10.66 86 252452 75886 110260875
Blood pressure decreased 27.07 10.66 153 252385 114938 110221823
Panic attack 26.82 10.66 134 252404 28806 110307955
Helicobacter infection 26.78 10.66 573 251965 181304 110155457
Oral candidiasis 26.62 10.66 38 252500 44722 110292039
Therapeutic product effective for unapproved indication 26.62 10.66 11 252527 152 110336609
Myasthenia gravis 26.61 10.66 8 252530 21503 110315258
Squamous cell carcinoma 26.50 10.66 5 252533 18458 110318303
Intestinal ischaemia 26.42 10.66 3 252535 16176 110320585
Lichen spinulosus 26.36 10.66 6 252532 6 110336755
Irritable bowel syndrome 26.36 10.66 524 252014 163691 110173070
Injection site pruritus 26.27 10.66 48 252490 51210 110285551
Ulcer 26.25 10.66 36 252502 43080 110293681
Self-destructive behaviour 26.19 10.66 19 252519 836 110335925
Radiculopathy 26.18 10.66 6 252532 19330 110317431
Asthenia 26.18 10.66 1296 251242 687703 109649058
Hyperventilation 26.16 10.66 61 252477 8886 110327875
Squamous cell carcinoma of skin 26.15 10.66 4 252534 17199 110319562
Acute coronary syndrome 26.15 10.66 10 252528 23102 110313659
Autism spectrum disorder 26.14 10.66 27 252511 1921 110334840
Inappropriate antidiuretic hormone secretion 26.09 10.66 149 252389 33702 110303059
Blood calcium decreased 26.04 10.66 26 252512 35819 110300942
Volvulus 26.03 10.66 36 252502 3482 110333279
Decreased interest 26.03 10.66 43 252495 4865 110331896
Compulsive shopping 25.93 10.66 19 252519 849 110335912
Staphylococcal infection 25.83 10.66 78 252460 69866 110266895
Mucosal erosion 25.71 10.66 32 252506 2792 110333969
Cardiac murmur 25.71 10.66 12 252526 24616 110312145
Suspiciousness 25.69 10.66 18 252520 749 110336012
Sputum discoloured 25.69 10.66 16 252522 27929 110308832
Drop attacks 25.64 10.66 21 252517 1107 110335654
Derealisation 25.57 10.66 28 252510 2130 110334631
Pulmonary congestion 25.46 10.66 20 252518 30946 110305815
Transferrin increased 25.46 10.66 7 252531 23 110336738
Neonatal infection 25.46 10.66 7 252531 23 110336738
Creatinine renal clearance decreased 25.42 10.66 9 252529 21806 110314955
Accidental death 25.38 10.66 43 252495 4966 110331795
Premature labour 25.16 10.66 61 252477 9111 110327650
Diabetes mellitus 25.09 10.66 129 252409 99252 110237509
Photophobia 25.08 10.66 121 252417 25650 110311111
Vision blurred 25.01 10.66 424 252114 128598 110208163
Hypotonia 24.96 10.66 86 252452 15659 110321102
Convulsive threshold lowered 24.89 10.66 20 252518 1026 110335735
Delusional perception 24.84 10.66 14 252524 395 110336366
Stress 24.80 10.66 140 252398 105208 110231553
Disorganised speech 24.74 10.66 34 252504 3269 110333492
Vascular device infection 24.73 10.66 4 252534 16508 110320253
Chapped lips 24.65 10.66 33 252505 3095 110333666
Anti-cyclic citrullinated peptide antibody positive 24.48 10.66 566 251972 181418 110155343
Agoraphobia 24.44 10.66 17 252521 699 110336062
Gangrene 24.39 10.66 4 252534 16337 110320424
Ventricular septal defect 24.38 10.66 17 252521 702 110336059
Drug level changed 24.21 10.66 16 252522 604 110336157
Microcephaly 24.14 10.66 11 252527 195 110336566
Pyramidal tract syndrome 24.09 10.66 18 252520 829 110335932
Spinal osteoarthritis 24.08 10.66 8 252530 20175 110316586
Rash vesicular 24.08 10.66 81 252457 14571 110322190
Gastroenteritis 24.02 10.66 32 252506 38768 110297993
Therapeutic product effect incomplete 23.91 10.66 675 251863 223130 110113631
Appendicitis 23.89 10.66 18 252520 28446 110308315
Vasculitis 23.87 10.66 28 252510 35845 110300916
Accidental overdose 23.81 10.66 201 252337 51633 110285128
Brain malformation 23.81 10.66 8 252530 59 110336702
Chorea 23.78 10.66 33 252505 3202 110333559
Concussion 23.78 10.66 69 252469 11469 110325292
Rapid eye movement sleep behaviour disorder 23.78 10.66 16 252522 623 110336138
Lymphadenitis 23.77 10.66 44 252494 5449 110331312
Musculoskeletal disorder 23.72 10.66 11 252527 22653 110314108
Essential tremor 23.59 10.66 25 252513 1833 110334928
Gastric haemorrhage 23.52 10.66 4 252534 15911 110320850
Neuralgia 23.45 10.66 47 252491 48431 110288330
False positive investigation result 23.45 10.66 22 252516 1392 110335369
Joint stiffness 23.42 10.66 77 252461 67166 110269595
Mouth ulceration 23.37 10.66 189 252349 47949 110288812
Body temperature decreased 23.34 10.66 30 252508 36905 110299856
Intention tremor 23.22 10.66 18 252520 876 110335885
Product administration error 23.14 10.66 155 252383 37062 110299699
Injury corneal 23.08 10.66 11 252527 217 110336544
Hepatocellular injury 23.07 10.66 196 252342 50446 110286315
Hyperuricaemia 22.97 10.66 3 252535 14528 110322233
Cerebellar ataxia 22.87 10.66 26 252512 2062 110334699
Lennox-Gastaut syndrome 22.64 10.66 12 252526 299 110336462
Unevaluable event 22.63 10.66 65 252473 59162 110277599
Bone disorder 22.63 10.66 10 252528 21182 110315579
Colon cancer 22.47 10.66 5 252533 16438 110320323
Symblepharon 22.44 10.66 14 252524 478 110336283
Bacteraemia 22.35 10.66 39 252499 42351 110294410
Diabetes mellitus inadequate control 22.33 10.66 21 252517 29754 110307007
Renal disorder 22.23 10.66 50 252488 49429 110287332
Flushing 22.13 10.66 144 252394 104592 110232169
Circulating anticoagulant 21.97 10.66 5 252533 5 110336756
Hypersomnia 21.95 10.66 124 252414 27937 110308824
Pneumothorax 21.95 10.66 29 252509 35256 110301505
Skin erosion 21.79 10.66 44 252494 5810 110330951
Altered pitch perception 21.75 10.66 6 252532 20 110336741
Haematoma 21.75 10.66 65 252473 58411 110278350
Hypoaesthesia 21.74 10.66 901 251637 313322 110023439
Atrial septal defect 21.72 10.66 26 252512 2179 110334582
Granulocytopenia 21.52 10.66 71 252467 12644 110324117
Pemphigoid 21.52 10.66 9 252529 19698 110317063
Haematocrit decreased 21.48 10.66 78 252460 66039 110270722
Respiratory acidosis 21.47 10.66 75 252463 13751 110323010
Haemorrhagic stroke 21.44 10.66 3 252535 13786 110322975
Pancreatic carcinoma 21.41 10.66 4 252534 14868 110321893
Pregnancy on contraceptive 21.32 10.66 18 252520 990 110335771
Therapy non-responder 21.27 10.66 243 252295 157064 110179697
Postoperative wound infection 21.11 10.66 5 252533 15748 110321013
Pre-eclampsia 21.08 10.66 55 252483 8595 110328166
Parasomnia 21.07 10.66 16 252522 755 110336006
Glycosylated haemoglobin increased 21.06 10.66 14 252524 23605 110313156
Glomerular filtration rate decreased 21.04 10.66 21 252517 28935 110307826
Spinal pain 20.96 10.66 8 252530 18507 110318254
Maternal drugs affecting foetus 20.96 10.66 22 252516 1595 110335166
Oral mucosal blistering 20.95 10.66 52 252486 7882 110328879
Large intestine perforation 20.91 10.66 6 252532 16623 110320138
Hyperammonaemia 20.90 10.66 74 252464 13658 110323103
Musculoskeletal chest pain 20.87 10.66 21 252517 28826 110307935
Oral mucosal eruption 20.85 10.66 19 252519 1158 110335603
Developmental regression 20.79 10.66 7 252531 52 110336709
Spinal compression fracture 20.74 10.66 8 252530 18384 110318377
Weight increased 20.74 10.66 1164 251374 418480 109918281
Retinal deposits 20.70 10.66 9 252529 142 110336619
Intestinal perforation 20.66 10.66 11 252527 20933 110315828
Small intestinal obstruction 20.53 10.66 26 252512 32187 110304574
Human herpesvirus 6 infection 20.49 10.66 46 252492 6535 110330226
Pseudomonas infection 20.47 10.66 20 252518 27833 110308928
Hyperexplexia 20.45 10.66 7 252531 55 110336706
Anti-cyclic citrullinated peptide antibody 20.42 10.66 10 252528 19954 110316807
Pneumonia bacterial 20.31 10.66 18 252520 26243 110310518
Electrocardiogram ST segment depression 20.27 10.66 41 252497 5420 110331341
Arterial occlusive disease 20.24 10.66 5 252533 15303 110321458
Regressive behaviour 20.20 10.66 10 252528 215 110336546
Impulse-control disorder 20.20 10.66 25 252513 2169 110334592
Forced expiratory volume decreased 20.17 10.66 3 252535 13173 110323588
Escherichia infection 20.07 10.66 15 252523 23801 110312960
Emphysema 20.05 10.66 10 252528 19746 110317015
Hepatosplenomegaly 20.04 10.66 47 252491 6872 110329889
Tooth infection 20.03 10.66 13 252525 22203 110314558
Skin warm 20.03 10.66 56 252482 9114 110327647
Poor venous access 19.96 10.66 16 252522 24506 110312255
Hepatic encephalopathy 19.96 10.66 21 252517 28235 110308526
Conjunctival abrasion 19.95 10.66 5 252533 10 110336751
Hyperhidrosis 19.95 10.66 304 252234 186994 110149767
Product name confusion 19.91 10.66 10 252528 222 110336539
Self-medication 19.90 10.66 44 252494 6188 110330573
Posterior reversible encephalopathy syndrome 19.89 10.66 29 252509 33832 110302929
Eye movement disorder 19.88 10.66 58 252480 9670 110327091
Large intestine polyp 19.86 10.66 5 252533 15112 110321649
Idiopathic generalised epilepsy 19.71 10.66 7 252531 62 110336699
Bronchospasm 19.69 10.66 24 252514 30215 110306546
Injection site haemorrhage 19.68 10.66 28 252510 33000 110303761
Tooth disorder 19.67 10.66 23 252515 29486 110307275
Obstructive airways disorder 19.64 10.66 48 252490 46101 110290660
Skin cancer 19.62 10.66 8 252530 17776 110318985
Product dose omission issue 19.59 10.66 572 251966 321210 110015551
Cytomegalovirus viraemia 19.58 10.66 8 252530 17756 110319005
Nephrogenic diabetes insipidus 19.58 10.66 26 252512 2419 110334342
Homicidal ideation 19.54 10.66 32 252506 3595 110333166
Angiomyolipoma 19.49 10.66 11 252527 311 110336450
Rotator cuff syndrome 19.45 10.66 7 252531 16787 110319974
Bipolar II disorder 19.44 10.66 13 252525 501 110336260
Differential white blood cell count abnormal 19.40 10.66 25 252513 2259 110334502
Lymphoma 19.31 10.66 11 252527 20160 110316601
Pulmonary alveolar haemorrhage 19.28 10.66 11 252527 20139 110316622
Coronary artery occlusion 19.27 10.66 6 252532 15766 110320995
Vestibular migraine 19.24 10.66 9 252529 170 110336591
Immune effector cell-associated neurotoxicity syndrome 19.21 10.66 5 252533 14777 110321984
Treatment failure 19.19 10.66 795 251743 276439 110060322
Joint effusion 19.17 10.66 12 252526 20893 110315868
Stereotypy 19.16 10.66 17 252521 1000 110335761
Bruxism 19.14 10.66 38 252500 4956 110331805
Blood iron decreased 19.09 10.66 10 252528 19204 110317557
Pectus excavatum 19.05 10.66 5 252533 13 110336748
Macule 18.98 10.66 32 252506 3681 110333080
Systemic lupus erythematosus 18.91 10.66 735 251803 253603 110083158
Orthostatic hypertension 18.91 10.66 17 252521 1018 110335743
Negative thoughts 18.89 10.66 21 252517 1625 110335136
Dermatitis exfoliative 18.89 10.66 63 252475 11284 110325477
Jaundice cholestatic 18.87 10.66 5 252533 14603 110322158
Failure to thrive 18.81 10.66 4 252534 13570 110323191
Diverticulum 18.80 10.66 6 252532 15520 110321241
Tongue biting 18.71 10.66 28 252510 2911 110333850
Dry eye 18.67 10.66 65 252473 55728 110281033
Paraesthesia oral 18.66 10.66 30 252508 33641 110303120
Platelet distribution width decreased 18.64 10.66 6 252532 38 110336723
Sleep paralysis 18.62 10.66 16 252522 902 110335859
Stupor 18.57 10.66 51 252487 8214 110328547
Affect lability 18.49 10.66 88 252450 18549 110318212
Ear infection 18.46 10.66 77 252461 62655 110274106
Cardiomyopathy 18.46 10.66 30 252508 33495 110303266
Endocarditis 18.41 10.66 4 252534 13367 110323394
Cardiovascular disorder 18.34 10.66 15 252523 22745 110314016
Lethargy 18.31 10.66 308 252230 93268 110243493
Left ventricular dysfunction 18.29 10.66 16 252522 23477 110313284
Lipids 18.28 10.66 5 252533 16 110336745
Hyperbilirubinaemia 18.28 10.66 26 252512 30645 110306116
Enterococcal infection 18.25 10.66 12 252526 20354 110316407
Scab 18.18 10.66 69 252469 13167 110323594
Transaminases increased 18.13 10.66 223 252315 63167 110273594
Benign cardiac neoplasm 18.13 10.66 6 252532 42 110336719
Hepatic cirrhosis 18.10 10.66 86 252452 67540 110269221
Placental infarction 18.08 10.66 8 252530 132 110336629
Nasal polyps 18.07 10.66 4 252534 13196 110323565
Urinary incontinence 18.06 10.66 180 252358 48407 110288354
Bile acid malabsorption 17.95 10.66 12 252526 462 110336299
Red blood cell sedimentation rate increased 17.92 10.66 105 252433 78197 110258564
Plateletcrit decreased 17.89 10.66 6 252532 44 110336717
Disseminated intravascular coagulation 17.87 10.66 158 252380 41128 110295633
Borderline personality disorder 17.86 10.66 17 252521 1095 110335666
Hypothermia 17.86 10.66 112 252426 26190 110310571
Coagulopathy 17.85 10.66 42 252496 40869 110295892
Pathological fracture 17.83 10.66 3 252535 12029 110324732
Cholestasis of pregnancy 17.82 10.66 18 252520 1247 110335514
Iron deficiency 17.80 10.66 10 252528 18466 110318295
Macular degeneration 17.79 10.66 14 252524 21645 110315116
Aortic stenosis 17.79 10.66 4 252534 13055 110323706
Drug tolerance decreased 17.79 10.66 22 252516 27518 110309243
Gastritis erosive 17.77 10.66 3 252535 11997 110324764
Erythema of eyelid 17.75 10.66 32 252506 3883 110332878
Tonsillar hypertrophy 17.71 10.66 22 252516 1916 110334845
Respiratory symptom 17.70 10.66 6 252532 14939 110321822
Anticonvulsant drug level therapeutic 17.62 10.66 5 252533 19 110336742
Myocardial ischaemia 17.57 10.66 21 252517 26663 110310098
Red blood cell count decreased 17.54 10.66 84 252454 65839 110270922
Drug ineffective 17.49 10.66 3824 248714 1516716 108820045
Acute graft versus host disease 17.44 10.66 4 252534 12877 110323884
Electrocardiogram QT shortened 17.43 10.66 10 252528 292 110336469
Burnout syndrome 17.39 10.66 11 252527 385 110336376
Ileus 17.39 10.66 27 252511 30702 110306059
Screaming 17.36 10.66 36 252502 4845 110331916
Weight fluctuation 17.34 10.66 15 252523 22130 110314631
Breast cancer 17.28 10.66 39 252499 38503 110298258
Lymphocyte morphology abnormal 17.23 10.66 16 252522 999 110335762
Herpangina 17.22 10.66 6 252532 50 110336711
Faeces discoloured 17.21 10.66 32 252506 33916 110302845
Anorgasmia 17.19 10.66 20 252518 1626 110335135
Insomnia 17.19 10.66 997 251541 359593 109977168
Viral rash 17.16 10.66 12 252526 498 110336263
Substance abuse 17.15 10.66 65 252473 12398 110324363
Bradypnoea 17.13 10.66 51 252487 8598 110328163
Exomphalos 17.12 10.66 7 252531 94 110336667
Hip fracture 17.07 10.66 34 252504 35117 110301644
Cardiovascular symptom 17.05 10.66 7 252531 95 110336666
Hereditary ataxia 17.04 10.66 5 252533 22 110336739
Anal abscess 17.03 10.66 3 252535 11635 110325126
Blood loss anaemia 17.01 10.66 10 252528 18015 110318746
Injection site rash 17.00 10.66 17 252521 23402 110313359
Retinal pigmentation 16.99 10.66 7 252531 96 110336665
Drug dose omission by device 16.89 10.66 6 252532 14510 110322251
Carpal tunnel syndrome 16.89 10.66 16 252522 22594 110314167
Coordination abnormal 16.86 10.66 107 252431 25121 110311640
Deja vu 16.86 10.66 7 252531 98 110336663
Respiratory syncytial virus infection 16.83 10.66 6 252532 14478 110322283
Coprolalia 16.81 10.66 6 252532 54 110336707
Renal injury 16.81 10.66 11 252527 18702 110318059
Inflammatory marker increased 16.81 10.66 6 252532 14463 110322298
Congenital anomaly 16.75 10.66 16 252522 1035 110335726
Encephalocele 16.72 10.66 6 252532 55 110336706
Prostatic specific antigen increased 16.71 10.66 4 252534 12507 110324254
Lymphocyte stimulation test positive 16.69 10.66 16 252522 1040 110335721
Wrong product administered 16.63 10.66 59 252479 10901 110325860
Breast cancer female 16.62 10.66 4 252534 12464 110324297
Self-injurious ideation 16.58 10.66 33 252505 4313 110332448
SARS-CoV-2 test positive 16.55 10.66 9 252529 16926 110319835
Flank pain 16.55 10.66 17 252521 23113 110313648
Emotional disorder 16.54 10.66 77 252461 16083 110320678
Autoimmune disorder 16.53 10.66 85 252453 65398 110271363
Exposure via transplant 16.52 10.66 5 252533 25 110336736
Pancreatitis acute 16.51 10.66 76 252462 60198 110276563
Resting tremor 16.45 10.66 20 252518 1703 110335058
Gastric disorder 16.42 10.66 32 252506 33325 110303436
Self esteem decreased 16.42 10.66 16 252522 1061 110335700
Snoring 16.39 10.66 43 252495 6741 110330020
Food allergy 16.25 10.66 13 252525 19935 110316826
Diabetic ketoacidosis 16.18 10.66 46 252492 42012 110294749
Hydronephrosis 16.18 10.66 14 252524 20651 110316110
Dissociative disorder 16.18 10.66 17 252521 1234 110335527
Genital erosion 16.17 10.66 14 252524 797 110335964
Limb injury 16.13 10.66 39 252499 37597 110299164
Upper-airway cough syndrome 16.13 10.66 8 252530 15849 110320912
Social avoidant behaviour 16.13 10.66 37 252501 5332 110331429
Impatience 16.13 10.66 14 252524 800 110335961
Breast cancer metastatic 16.11 10.66 3 252535 11178 110325583
Flight of ideas 16.10 10.66 14 252524 802 110335959
Vomiting projectile 16.08 10.66 23 252515 2295 110334466
Tendon rupture 16.08 10.66 6 252532 14072 110322689
Muscle spasms 16.04 10.66 783 251755 277374 110059387
Decubitus ulcer 16.00 10.66 11 252527 18225 110318536
Plagiocephaly 16.00 10.66 6 252532 63 110336698
Tongue eruption 15.99 10.66 8 252530 176 110336585
Feeling of despair 15.90 10.66 30 252508 3768 110332993
Drug screen positive 15.87 10.66 41 252497 6369 110330392
Renal cancer 15.85 10.66 5 252533 13029 110323732
Rheumatic fever 15.79 10.66 379 252159 122200 110214561
Patent ductus arteriosus 15.79 10.66 8 252530 181 110336580
Autoimmune hepatitis 15.78 10.66 7 252531 14797 110321964
Hypertension 15.75 10.66 979 251559 509105 109827656
Adenovirus infection 15.73 10.66 3 252535 10991 110325770
Rales 15.73 10.66 20 252518 24719 110312042
Infective pulmonary exacerbation of cystic fibrosis 15.73 10.66 7 252531 14764 110321997
Pulmonary haemorrhage 15.72 10.66 9 252529 16447 110320314
Physical assault 15.71 10.66 19 252519 1609 110335152
Cleft lip 15.64 10.66 4 252534 9 110336752
Mucosal ulceration 15.62 10.66 23 252515 2356 110334405
Glaucoma 15.61 10.66 17 252521 22500 110314261
Post procedural haemorrhage 15.52 10.66 8 252530 15504 110321257
Delivery 15.51 10.66 15 252523 986 110335775
Enuresis 15.50 10.66 31 252507 4065 110332696
Post procedural complication 15.49 10.66 23 252515 26635 110310126
Astrocytoma, low grade 15.47 10.66 7 252531 122 110336639
Groin pain 15.37 10.66 8 252530 15420 110321341
Coma scale 15.36 10.66 6 252532 71 110336690
Congenital renal disorder 15.35 10.66 4 252534 10 110336751
Adjustment disorder 15.33 10.66 3 252535 10792 110325969
Immune reconstitution inflammatory syndrome 15.32 10.66 9 252529 16217 110320544
Judgement impaired 15.32 10.66 17 252521 1313 110335448
Pregnancy with contraceptive device 15.30 10.66 30 252508 3877 110332884
Wrong patient 15.30 10.66 18 252520 1481 110335280
Congenital cardiovascular anomaly 15.25 10.66 3 252535 0 110336761
Neonatal aspiration 15.25 10.66 3 252535 0 110336761
Lip oedema 15.23 10.66 45 252493 7555 110329206
Epidermolysis 15.22 10.66 16 252522 1162 110335599
Brain death 15.21 10.66 41 252497 6532 110330229
Renal tubular necrosis 15.21 10.66 29 252509 30446 110306315
Gait disturbance 15.19 10.66 779 251759 277429 110059332
Pericardial effusion 15.17 10.66 73 252465 57144 110279617
Miosis 15.17 10.66 94 252444 21889 110314872
Opsoclonus myoclonus 15.15 10.66 9 252529 281 110336480
Hallucinations, mixed 15.13 10.66 49 252489 8644 110328117
Product packaging confusion 15.10 10.66 10 252528 379 110336382
Sensory loss 15.09 10.66 16 252522 21441 110315320
Nephrolithiasis 15.04 10.66 89 252449 66123 110270638
Alopecia universalis 15.03 10.66 10 252528 382 110336379
Blood urine present 15.00 10.66 20 252518 24225 110312536
Selective IgG subclass deficiency 14.98 10.66 5 252533 36 110336725
Manic symptom 14.98 10.66 9 252529 287 110336474
Euglycaemic diabetic ketoacidosis 14.97 10.66 4 252534 11619 110325142
Haemorrhage intracranial 14.96 10.66 27 252511 28942 110307819
Aphasia 14.96 10.66 203 252335 58794 110277967
Product dose omission in error 14.96 10.66 19 252519 23493 110313268
Deep vein thrombosis postoperative 14.94 10.66 77 252461 59214 110277547
Iron deficiency anaemia 14.92 10.66 31 252507 31528 110305233
Cytomegalovirus infection reactivation 14.87 10.66 12 252526 18321 110318440
Somnambulism 14.87 10.66 40 252498 6365 110330396
Colitis microscopic 14.82 10.66 6 252532 13388 110323373
Product use in unapproved indication 14.80 10.66 1200 251338 446177 109890584
Hospice care 14.79 10.66 5 252533 12468 110324293
Corneal defect 14.75 10.66 5 252533 38 110336723
Mitral valve incompetence 14.72 10.66 34 252504 33295 110303466
Apnoea 14.71 10.66 66 252472 13573 110323188
Illogical thinking 14.71 10.66 6 252532 80 110336681
Spinal fracture 14.70 10.66 18 252520 22615 110314146
Polyarthritis 14.66 10.66 13 252525 18950 110317811
Generalised oedema 14.65 10.66 30 252508 30674 110306087
Rhabdomyolysis 14.53 10.66 369 252169 120032 110216729
Therapeutic product ineffective for unapproved indication 14.49 10.66 9 252529 305 110336456
Pyelonephritis 14.47 10.66 22 252516 25228 110311533
Blood calcium increased 14.40 10.66 12 252526 18028 110318733
Erysipelas 14.38 10.66 6 252532 13152 110323609
Eyelid oedema 14.38 10.66 71 252467 15191 110321570
Hypospadias 14.38 10.66 7 252531 145 110336616
Tachycardia 14.35 10.66 644 251894 226001 110110760
Secretion discharge 14.35 10.66 15 252523 20229 110316532
Hypnagogic hallucination 14.35 10.66 8 252530 221 110336540
Anxiety disorder 14.34 10.66 34 252504 5006 110331755
Hyperhomocysteinaemia 14.29 10.66 12 252526 655 110336106
Limbic encephalitis 14.23 10.66 13 252525 795 110335966
Febrile convulsion 14.20 10.66 15 252523 1095 110335666
Drug withdrawal syndrome 14.15 10.66 141 252397 37913 110298848
Conjunctival disorder 14.15 10.66 10 252528 422 110336339
Respiratory depression 14.13 10.66 123 252415 31878 110304883
Echolalia 14.11 10.66 11 252527 540 110336221
Limb discomfort 14.07 10.66 47 252491 40807 110295954
Metabolic function test abnormal 14.06 10.66 12 252526 670 110336091
Lipids abnormal 14.02 10.66 12 252526 673 110336088
Respiratory tract congestion 14.01 10.66 31 252507 30826 110305935
Foreign body in reproductive tract 13.98 10.66 14 252524 960 110335801
Musculoskeletal discomfort 13.98 10.66 20 252518 23518 110313243
Blood magnesium decreased 13.97 10.66 15 252523 19981 110316780
Gastric ulcer haemorrhage 13.93 10.66 3 252535 10091 110326670
Lymphocytic infiltration 13.91 10.66 20 252518 2005 110334756
Blood glucose decreased 13.91 10.66 29 252509 29459 110307302
Internal haemorrhage 13.89 10.66 3 252535 10068 110326693
Sexual dysfunction 13.88 10.66 47 252491 8483 110328278
Skin haemorrhage 13.87 10.66 22 252516 24805 110311956
Device issue 13.87 10.66 37 252501 34498 110302263
Acute encephalitis with refractory, repetitive partial seizures 13.82 10.66 5 252533 47 110336714
Gestational hypertension 13.82 10.66 21 252517 2213 110334548
Limited symptom panic attack 13.64 10.66 5 252533 49 110336712
Morose 13.64 10.66 5 252533 49 110336712
Clumsiness 13.58 10.66 28 252510 3752 110333009
Pupillary reflex impaired 13.56 10.66 29 252509 3986 110332775
Aortic aneurysm 13.56 10.66 3 252535 9901 110326860
Seasonal allergy 13.55 10.66 15 252523 19707 110317054
Conjunctival erosion 13.54 10.66 8 252530 247 110336514
Device occlusion 13.54 10.66 9 252529 15176 110321585
Anal fissure 13.51 10.66 3 252535 9878 110326883
Acute psychosis 13.50 10.66 33 252505 4954 110331807
Intestinal obstruction 13.49 10.66 69 252469 53158 110283603
Dialysis 13.39 10.66 15 252523 19604 110317157
Immunosuppressant drug level increased 13.38 10.66 5 252533 11719 110325042
Hallucination, olfactory 13.38 10.66 11 252527 583 110336178
Head titubation 13.36 10.66 16 252522 1341 110335420
Cushingoid 13.36 10.66 5 252533 11707 110325054
Hypovolaemia 13.29 10.66 18 252520 21656 110315105
Cerebral disorder 13.29 10.66 40 252498 6786 110329975
Device difficult to use 13.25 10.66 14 252524 18791 110317970
Thyroiditis 13.25 10.66 39 252499 6534 110330227
Hypertensive crisis 13.24 10.66 22 252516 24350 110312411
Blood potassium decreased 13.23 10.66 71 252467 54043 110282718
Cholecystitis acute 13.22 10.66 10 252528 15772 110320989
Amniocentesis abnormal 13.18 10.66 3 252535 3 110336758
Progressive multifocal leukoencephalopathy 13.12 10.66 23 252515 24933 110311828
Joint injury 13.11 10.66 47 252491 39947 110296814
Purpura 13.08 10.66 98 252440 24290 110312471
Protrusion tongue 13.06 10.66 10 252528 478 110336283
Attention-seeking behaviour 13.04 10.66 6 252532 109 110336652
Oesophageal candidiasis 13.03 10.66 5 252533 11529 110325232
Rhinitis allergic 13.02 10.66 13 252525 17909 110318852
Autoscopy 12.99 10.66 6 252532 110 110336651
Bone erosion 12.98 10.66 58 252480 46313 110290448
Abscess 12.97 10.66 27 252511 27442 110309319
Proctalgia 12.96 10.66 7 252531 13215 110323546
Therapy interrupted 12.96 10.66 64 252474 49758 110287003
Torticollis 12.94 10.66 25 252513 3196 110333565
Talipes 12.94 10.66 7 252531 182 110336579
Musculoskeletal stiffness 12.92 10.66 515 252023 279307 110057454
Activation syndrome 12.92 10.66 9 252529 371 110336390
Selective IgA immunodeficiency 12.90 10.66 4 252534 22 110336739
Carotid artery occlusion 12.89 10.66 3 252535 9562 110327199
Mononucleosis heterophile test positive 12.72 10.66 3 252535 4 110336757
Ideas of reference 12.70 10.66 7 252531 189 110336572
Infantile spasms 12.69 10.66 9 252529 382 110336379
Urticaria 12.69 10.66 868 251670 317989 110018772
Bacterial sepsis 12.67 10.66 4 252534 10422 110326339
Postmortem blood drug level abnormal 12.67 10.66 11 252527 629 110336132
Visual field defect 12.61 10.66 51 252487 10021 110326740
Gastrointestinal disorder 12.58 10.66 439 252099 241513 110095248
Malignant melanoma 12.56 10.66 12 252526 16879 110319882
Post procedural infection 12.56 10.66 8 252530 13801 110322960
Gait deviation 12.56 10.66 6 252532 119 110336642
Areflexia 12.55 10.66 39 252499 6730 110330031
Red cell distribution width increased 12.52 10.66 13 252525 17589 110319172
Hyperphagia 12.50 10.66 26 252512 3505 110333256
Dysmetropsia 12.47 10.66 6 252532 121 110336640
Bone density decreased 12.40 10.66 11 252527 16031 110320730
Basilar artery occlusion 12.35 10.66 8 252530 292 110336469
Small for dates baby 12.34 10.66 11 252527 651 110336110
Eye discharge 12.33 10.66 46 252492 8708 110328053
Dysphemia 12.33 10.66 28 252510 4009 110332752
Laryngeal tremor 12.32 10.66 3 252535 5 110336756
Wound 12.30 10.66 654 251884 233783 110102978
Haemodynamic instability 12.29 10.66 92 252446 22796 110313965
Renal cyst 12.29 10.66 14 252524 18158 110318603
Tongue movement disturbance 12.28 10.66 10 252528 523 110336238
Blood oestrogen increased 12.25 10.66 7 252531 203 110336558
Non-cardiac chest pain 12.24 10.66 4 252534 10194 110326567
Escherichia bacteraemia 12.18 10.66 4 252534 10160 110326601
Duodenal ulcer 12.18 10.66 16 252522 19498 110317263
Dyslexia 12.15 10.66 9 252529 409 110336352
Tooth abscess 12.14 10.66 15 252523 18774 110317987
Restless legs syndrome 12.12 10.66 97 252441 24529 110312232
Compulsions 12.11 10.66 9 252529 411 110336350
Headache 12.10 10.66 1799 250739 880578 109456183
Oral mucosal erythema 12.10 10.66 20 252518 2264 110334497
Pulmonary tuberculosis 12.05 10.66 3 252535 9136 110327625
Vitreous floaters 12.04 10.66 3 252535 9131 110327630
Hyperthyroidism 12.01 10.66 31 252507 29230 110307531
Gastrointestinal hypomotility 12.01 10.66 21 252517 2487 110334274
Myocarditis 11.98 10.66 113 252425 29942 110306819
Hemiplegia 11.98 10.66 21 252517 22761 110314000
Congenital renal cyst 11.97 10.66 3 252535 6 110336755
Wound healing normal 11.97 10.66 3 252535 6 110336755
Hyperkinesia 11.93 10.66 24 252514 3160 110333601
Anticoagulation drug level abnormal 11.88 10.66 8 252530 312 110336449
Premature rupture of membranes 11.83 10.66 30 252508 4607 110332154
Eye pruritus 11.78 10.66 37 252501 32738 110304023
Conjunctival irritation 11.75 10.66 6 252532 138 110336623
Ankylosing spondylitis 11.72 10.66 11 252527 15601 110321160
Drug level above therapeutic 11.70 10.66 55 252483 11533 110325228
Product administration interrupted 11.70 10.66 54 252484 11238 110325523
Cogwheel rigidity 11.68 10.66 26 252512 3672 110333089
Tuberous sclerosis complex 11.67 10.66 6 252532 140 110336621
Enthesopathy 11.67 10.66 7 252531 12471 110324290
Unintentional medical device removal 11.63 10.66 3 252535 8920 110327841
Visuospatial deficit 11.62 10.66 4 252534 32 110336729
Paralogism 11.62 10.66 4 252534 32 110336729
Metabolic syndrome 11.61 10.66 24 252514 3223 110333538
Polyneuropathy 11.60 10.66 36 252502 31976 110304785
Personality disorder 11.58 10.66 59 252479 12778 110323983
Aortic valve thickening 11.57 10.66 7 252531 226 110336535
Phlebitis 11.57 10.66 4 252534 9837 110326924
Diastolic dysfunction 11.54 10.66 7 252531 12397 110324364
Skin laceration 11.51 10.66 39 252499 33714 110303047
Strabismus 11.51 10.66 25 252513 3474 110333287
Dermatitis bullous 11.50 10.66 74 252464 17455 110319306
Urosepsis 11.48 10.66 34 252504 30641 110306120
Abdominal abscess 11.43 10.66 3 252535 8816 110327945
Verbigeration 11.41 10.66 4 252534 34 110336727
Illiteracy 11.41 10.66 4 252534 34 110336727
Kidney infection 11.39 10.66 26 252512 25573 110311188
Conjunctival ulcer 11.38 10.66 5 252533 81 110336680
Mucormycosis 11.37 10.66 5 252533 10623 110326138
Ageusia 11.37 10.66 17 252521 19628 110317133
Incorrect product administration duration 11.35 10.66 83 252455 20415 110316346
Drug withdrawal syndrome neonatal 11.33 10.66 8 252530 337 110336424
Ulcerative keratitis 11.30 10.66 30 252508 4736 110332025
Body height decreased 11.25 10.66 5 252533 10558 110326203
Viral infection 11.25 10.66 73 252465 53066 110283695
Food craving 11.23 10.66 18 252520 1985 110334776
Tooth malformation 11.23 10.66 6 252532 152 110336609
Peritonitis bacterial 11.20 10.66 5 252533 10528 110326233
Deafness 11.20 10.66 28 252510 26681 110310080
Teratogenicity 11.14 10.66 7 252531 242 110336519
Antipsychotic drug level above therapeutic 11.13 10.66 20 252518 2420 110334341
Niemann-Pick disease 11.11 10.66 4 252534 37 110336724
Antidepressant drug level above therapeutic 11.09 10.66 11 252527 746 110336015
Acquired immunodeficiency syndrome 11.07 10.66 8 252530 350 110336411
Subarachnoid haemorrhage 11.05 10.66 33 252505 29669 110307092
Central nervous system lesion 11.04 10.66 67 252471 15486 110321275
Endotracheal intubation 11.03 10.66 35 252503 6109 110330652
Diffuse large B-cell lymphoma 11.02 10.66 12 252526 15886 110320875
Bankruptcy 11.02 10.66 4 252534 38 110336723
Wrist fracture 11.01 10.66 10 252528 14407 110322354
Aphonia 10.96 10.66 8 252530 12852 110323909
Ear discomfort 10.96 10.66 6 252532 11243 110325518
Faeces soft 10.90 10.66 6 252532 11204 110325557
Sneezing 10.88 10.66 37 252501 31947 110304814
Atelectasis 10.84 10.66 45 252493 36667 110300094
Frontal lobe epilepsy 10.84 10.66 4 252534 40 110336721
Lung disorder 10.84 10.66 509 252029 179538 110157223
Odynophagia 10.82 10.66 62 252476 14039 110322722
Sexually transmitted disease 10.82 10.66 6 252532 164 110336597
Eclampsia 10.79 10.66 8 252530 364 110336397
Gambling 10.79 10.66 8 252530 364 110336397
Neuropsychiatric symptoms 10.79 10.66 14 252524 1274 110335487
Lip disorder 10.78 10.66 16 252522 1651 110335110
Anal fistula 10.76 10.66 3 252535 8470 110328291
Skin infection 10.73 10.66 22 252516 22487 110314274
Heavy menstrual bleeding 10.69 10.66 69 252469 16296 110320465

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 36.86 20.00 36 2548 4938 106431
Dehydration 28.39 20.00 45 2539 458 110911
Somnolence 27.43 20.00 43 2541 433 110936
Gastrooesophageal reflux disease 20.67 20.00 11 2573 18 111351

Pharmacologic Action:

SourceCodeDescription
ATC N03AX09 NERVOUS SYSTEM
ANTIEPILEPTICS
ANTIEPILEPTICS
Other antiepileptics
FDA MoA N0000000191 Dihydrofolate Reductase Inhibitors
FDA PE N0000008486 Decreased Central Nervous System Disorganized Electrical Activity
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D000927 Anticonvulsants
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D002317 Cardiovascular Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014150 Antipsychotic Agents
MeSH PA D026941 Sodium Channel Blockers
MeSH PA D049990 Membrane Transport Modulators
CHEBI has role CHEBI:35469 antidepressant
CHEBI has role CHEBI:35474 anxiolytic drug
CHEBI has role CHEBI:35476 antipsychotic agent
CHEBI has role CHEBI:35477 antimanic drug
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:35481 non-narcotic analgesic
CHEBI has role CHEBI:35623 anticonvulsant
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:38215 calcium channel blocker
CHEBI has role CHEBI:60798 excitatory amino acid antagonist
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:76779 EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
CHEBI has role CHEBI:78298 environmental contaminant
CHEBI has role CHEBI:176497 geroprotector
FDA EPC N0000175751 Mood Stabilizer
FDA EPC N0000175753 Anti-epileptic Agent
FDA MoA N0000187061 Organic Cation Transporter 2 Inhibitors

Related Drugs by ATC class:

N03AX Other antiepileptics 18 drugs
beclamidebrivaracetamcannabidiolcarisbamatecenobamatefelbamatefenfluramineganaxolonelacosamidelevetiracetamperampanelphenacemide show all 18 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tonic-clonic seizure indication 54200006
Epilepsy indication 84757009 DOID:1826
Bipolar disorder in remission indication 85248005
Lennox-Gastaut syndrome indication 230418006
Epilepsy characterized by intractable complex partial seizures indication 442481002
Simple partial seizure indication 117891000119100
Bipolar affective disorder, current episode depression off-label use 191627008 DOID:3312
Neuropathic pain off-label use 247398009
Rapid Cycling Bipolar Affective Disorder off-label use
Suicidal thoughts contraindication 6471006
Depressive disorder contraindication 35489007
Acute nephropathy contraindication 58574008
Pancytopenia contraindication 127034005 DOID:12450
Non-infective meningitis contraindication 230155003
Disease of liver contraindication 235856003 DOID:409
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Aplastic anemia contraindication 306058006 DOID:12449




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.3 Basic
pKa2 0.0 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/ML SUBVENITE OWP PHARMS N218879 Sept. 16, 2025 RX SUSPENSION ORAL 11596634 May 29, 2040 ADJUNCTIVE THERAPY FOR PARTIAL-ONSET, PRIMARY GENERALIZED TONIC-CLONIC (PGTC), OR LENNOX-GASTAUT SEIZURES IN PATIENTS 2 YEARS AND OLDER
10MG/ML SUBVENITE OWP PHARMS N218879 Sept. 16, 2025 RX SUSPENSION ORAL 11596634 May 29, 2040 CONVERSION TO MONOTHERAPY FOR PARTIAL-ONSET SEIZURES IN PATIENTS 16 YEARS AND OLDER
10MG/ML SUBVENITE OWP PHARMS N218879 Sept. 16, 2025 RX SUSPENSION ORAL 11596634 May 29, 2040 MAINTENANCE TREATMENT OF BIPOLAR I DISORDER TO DELAY MOOD EPISODES
10MG/ML SUBVENITE OWP PHARMS N218879 Sept. 16, 2025 RX SUSPENSION ORAL 11612566 May 29, 2040 ADJUNCTIVE THERAPY FOR PARTIAL-ONSET, PRIMARY GENERALIZED TONIC-CLONIC (PGTC), OR LENNOX-GASTAUT SEIZURES IN PATIENTS 2 YEARS AND OLDER
10MG/ML SUBVENITE OWP PHARMS N218879 Sept. 16, 2025 RX SUSPENSION ORAL 11612566 May 29, 2040 CONVERSION TO MONOTHERAPY FOR PARTIAL-ONSET SEIZURES IN PATIENTS 16 YEARS AND OLDER
10MG/ML SUBVENITE OWP PHARMS N218879 Sept. 16, 2025 RX SUSPENSION ORAL 11612566 May 29, 2040 MAINTENANCE TREATMENT OF BIPOLAR I DISORDER TO DELAY MOOD EPISODES
10MG/ML SUBVENITE OWP PHARMS N218879 Sept. 16, 2025 RX SUSPENSION ORAL 12629377 May 29, 2040 CONVERSION TO MONOTHERAPY IN ADULTS 16 YEARS AND OLDER WITH PARTIAL-ONSET SEIZURES WHO ARE RECEIVING CARBAMAZEPINE, PHENYTOIN, PHENOBARBITAL, PRIMIDONE, OR VALPROATE AS THE SINGLE ANTIEPILEPTIC DRUG
10MG/ML SUBVENITE OWP PHARMS N218879 Sept. 16, 2025 RX SUSPENSION ORAL 12629377 May 29, 2040 MAINTENANCE TREATMENT OF BIPOLAR I DISORDER TO DELAY THE TIME TO OCCURRENCE OF MOOD EPISODES IN PATIENTS TREATED FOR ACUTE MOOD EPISODES WITH STANDARD THERAPY
10MG/ML SUBVENITE OWP PHARMS N218879 Sept. 16, 2025 RX SUSPENSION ORAL 12629377 May 29, 2040 TREATMENT OF EPILEPSY AS ADJUNCTIVE THERAPY IN PATIENTS 2 YEARS AND OLDER WITH PARTIAL-ONSET SEIZURES, PRIMARY GENERALIZED TONIC-CLONIC SEIZURES, OR GENERALIZED SEIZURES OF LENNOX-GASTAUT SYNDROME

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER IC50 4.21 CHEMBL CHEMBL
Sodium channel protein type 1 subunit alpha Ion channel BLOCKER DRUGBANK CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel BLOCKER IC50 5 CHEMBL CHEMBL
Sodium channel protein type 3 subunit alpha Ion channel BLOCKER IC50 4.77 CHEMBL CHEMBL
Sodium channel protein type 4 subunit alpha Ion channel BLOCKER Ki 4.77 CHEMBL CHEMBL
Sodium channel protein type 8 subunit alpha Ion channel BLOCKER DRUGBANK CHEMBL
Sodium channel protein type 9 subunit alpha Ion channel BLOCKER IC50 4.77 CHEMBL CHEMBL
Sodium channel protein type 10 subunit alpha Ion channel BLOCKER IC50 4.02 CHEMBL CHEMBL
Sigma non-opioid intracellular receptor 1 Membrane receptor IC50 3.84 WOMBAT-PK
5-hydroxytryptamine receptor 3A Ion channel IC50 4.74 WOMBAT-PK
Sodium channel protein type X alpha subunit Ion channel IC50 4.60 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.82 CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel IC50 4.46 CHEMBL
Dihydrofolate reductase Enzyme Ki 4.82 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.51 CHEMBL

External reference:

IDSource
D00354 KEGG_DRUG
4020896 VANDF
C0064636 UMLSCUI
CHEBI:6367 CHEBI
CHEMBL741 ChEMBL_ID
DB00555 DRUGBANK_ID
D000077213 MESH_DESCRIPTOR_UI
3878 PUBCHEM_CID
2622 IUPHAR_LIGAND_ID
5638 INN_ID
U3H27498KS UNII
196502 RXNORM
1506 MMSL
4957 MMSL
69610 MMSL
d03809 MMSL
003988 NDDF
387562000 SNOMEDCT_US
96195007 SNOMEDCT_US
IYJ PDB_CHEM_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1526 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1527 TABLET, ORALLY DISINTEGRATING 50 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1528 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-1529 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 29 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9939 TABLET, ORALLY DISINTEGRATING 25 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9940 TABLET, ORALLY DISINTEGRATING 50 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9941 TABLET, ORALLY DISINTEGRATING 100 mg ORAL ANDA 28 sections
Lamotrigine HUMAN PRESCRIPTION DRUG LABEL 1 0115-9942 TABLET, ORALLY DISINTEGRATING 200 mg ORAL ANDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0526 TABLET, FOR SUSPENSION 5 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0526 TABLET, FOR SUSPENSION 5 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0527 TABLET, FOR SUSPENSION 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0527 TABLET, FOR SUSPENSION 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0633 TABLET 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0633 TABLET 25 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0642 TABLET 100 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0642 TABLET 100 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0643 TABLET 150 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0643 TABLET 150 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0644 TABLET 200 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0644 TABLET 200 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0699 TABLET, FOR SUSPENSION 2 mg ORAL NDA 28 sections
LAMICTAL HUMAN PRESCRIPTION DRUG LABEL 1 0173-0699 TABLET, FOR SUSPENSION 2 mg ORAL NDA 28 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0754 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0754 TABLET, FILM COATED, EXTENDED RELEASE 25 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0755 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0755 TABLET, FILM COATED, EXTENDED RELEASE 50 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0756 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0756 TABLET, FILM COATED, EXTENDED RELEASE 100 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0757 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL NDA 29 sections
LAMICTALXR HUMAN PRESCRIPTION DRUG LABEL 1 0173-0757 TABLET, FILM COATED, EXTENDED RELEASE 200 mg ORAL NDA 29 sections