diiodohydroxyquinoline

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Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	4.107		Moderate	0.71
caco2-efflux	Caco-2 efflux ratio (BA/AB)	0.303		Moderate	0.71
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	14.689	10^-6 cm/s	Moderate	0.71
dh-clint	Dog hepatocyte intrinsic clearance	148.936	uL/min/10^6 cells	Moderate	0.71
dppb	Dog plasma protein binding (% unbound)	0.170	%	Moderate	0.71
fcs-ppb	Fetal calf serum protein binding (% unbound)	0.240	%	Moderate	0.71
herg	hERG pIC50	4.702	pIC50	Moderate	0.71
hh-clint	Human hepatocyte intrinsic clearance	100.462	uL/min/10^6 cells	Moderate	0.71
hlm-clint	Human liver microsomal intrinsic clearance	34.995	uL/min/mg protein	Moderate	0.71
hppb	Human plasma protein binding (% unbound)	0.380	%	Moderate	0.71
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKB,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK2,CDK4,CDK5,CDK7,CDK9,CHEK1,CLK4,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3A,GSK3B,IKBKB,IRAK1,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K1,MAP2K6,MAP3K1,MAP3K10,MAP3K11,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM1,PIM2,PIM3,PLK1,PRKAA1,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK10,STK33,SYK,TEK,TGFBR1,TTK,UHMK1,ULK1,ULK2,ZAP70	92
kinase-selectivity-class	ACVR2B,AURKA,AXL,BRAF,CAMK2D,CDK4,CDK9,DDR1,DYRK1B,EIF2AK3,GRK2,GSK3B,MAP2K1,MAP2K3,MAP2K6,MAPK1,MAPK12,MAPK7,MARK4,PIK3CB,PRKDC,SIK2,STK33,SYK,TEK,TTK,ULK1	27
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	0.242		Moderate	0.71
mh-clint	Mouse hepatocyte intrinsic clearance	483.059		Moderate	0.71
mppb	Mouse plasma protein binding (% unbound)	0.370		Moderate	0.71
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	0.072		Moderate	0.71
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pppb	Pig plasma protein binding (% unbound)	0.200	%	Moderate	0.71
rh-clint	Rat hepatocyte intrinsic clearance	338.065	uL/min/10^6 cells	Moderate	0.71
rh-fuinc	Rat hepatocyte fraction unbound in incubation	4.440	%	Moderate	0.71
rppb	Rat plasma protein binding (% unbound)	0.120	%	Moderate	0.71
solubility-dd	Solubility at pH 7.4 in DMSO	1.156	uM	Moderate	0.71

Source	Code	Description
ATC	G01AC01	GENITO URINARY SYSTEM AND SEX HORMONES GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS Quinoline derivatives
MeSH PA	D000563	Amebicides
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000977	Antiparasitic Agents
MeSH PA	D000981	Antiprotozoal Agents
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:35820	antiprotozoal drug
CHEBI has role	CHEBI:48218	antiseptic drug
CHEBI has role	CHEBI:171664	antiamoebic agent

Disease	Relation	SNOMED_ID	DOID
Amebic infection	indication	111910009	DOID:9181
Atopic dermatitis	off-label use	24079001	DOID:3310
Contact dermatitis	off-label use	40275004	DOID:2773
Lichen simplex chronicus	off-label use	53891004
Pruritus ani	off-label use	90446007
Pruritus of genital organs	off-label use	267802000
Eruption of skin	off-label use	271807003	DOID:0050486
Optic neuritis	contraindication	66760008	DOID:1210
Disease of liver	contraindication	235856003	DOID:409
Telangiectasia disorder	contraindication	247479008
Peripheral nerve disease	contraindication	302226006
Adrenal cortical hypofunction	contraindication	386584007	DOID:10493
Atrophoderma	contraindication	399979006
Peripheral vascular disease	contraindication	400047006

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.61	acidic
pKa2	2.03	Basic

Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Adenosine receptor A3	GPCR	P0DMS8	AA3R_HUMAN	Ki	6.28	DRUG MATRIX
Epidermal growth factor receptor	Kinase	P00533	EGFR_HUMAN	IC50	5.72	DRUG MATRIX
Tyrosine-protein kinase Lck	Kinase	P06239	LCK_HUMAN	IC50	5.61	DRUG MATRIX
Tyrosine-protein kinase Fyn	Kinase	P06241	FYN_HUMAN	IC50	5.80	DRUG MATRIX
Receptor tyrosine-protein kinase erbB-2	Kinase	P04626	ERBB2_HUMAN	IC50	5.07	DRUG MATRIX
Mitogen-activated protein kinase 3	Kinase	P27361	MK03_HUMAN	IC50	5.28	DRUG MATRIX
Mitogen-activated protein kinase 14	Kinase	Q16539	MK14_HUMAN	IC50	6.44	DRUG MATRIX
Mitogen-activated protein kinase 1	Kinase	P28482	MK01_HUMAN	IC50	6.53	DRUG MATRIX
Angiotensin-converting enzyme	Enzyme		ACE_RABIT	IC50	6.04	DRUG MATRIX
Catechol O-methyltransferase	Enzyme		COMT_RAT	IC50	5.25	CHEMBL
Beta-lactamase NDM-1	Enzyme		BLAN1_KLEPN	IC50	5.60	CHEMBL

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diiodohydroxyquinoline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products:

ID	Source
4018600	VUID
N0000146916	NUI
D00581	KEGG_DRUG
4018600	VANDF
C0012341	UMLSCUI
CHEBI:5950	CHEBI
CHEMBL86754	ChEMBL_ID
DB09115	DRUGBANK_ID
3728	PUBCHEM_CID
3435	RXNORM
2439	MMSL
4903	MMSL
d01105	MMSL
002952	NDDF
387355005	SNOMEDCT_US
64851009	SNOMEDCT_US
D004103	MESH_DESCRIPTOR_UI
1613	INN_ID
63W7IE88K8	UNII

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Vytone	HUMAN PRESCRIPTION DRUG LABEL	2	44118-704	CREAM	10 mg	TOPICAL	unapproved drug other	9 sections
HYDROCORTISONE, IODOQUINOL	HUMAN PRESCRIPTION DRUG LABEL	2	52187-532	CREAM	10 mg	TOPICAL	unapproved drug other	11 sections
Hydrocortisone Acetate, Iodoquinol	HUMAN PRESCRIPTION DRUG LABEL	2	52187-551	CREAM	10 mg	TOPICAL	unapproved drug other	9 sections
Alcortin	HUMAN PRESCRIPTION DRUG LABEL	2	68040-702	GEL	1 g	TOPICAL	unapproved drug other	2 sections
Alcortin A	HUMAN PRESCRIPTION DRUG LABEL	3	68040-705	GEL	10 mg	TOPICAL	UNAPPROVED OTHER	17 sections
Aloquin	HUMAN PRESCRIPTION DRUG LABEL	2	68040-706	GEL	12.50 mg	TOPICAL	Unapproved other	15 sections
IODOQUINOL HYDROCORTISONE ACETATE ALOE POLYSACCHARIDES	HUMAN PRESCRIPTION DRUG LABEL	3	72056-020	GEL	10 mg	TOPICAL	UNAPPROVED DRUG OTHER	17 sections
HYDROCORTISONE IODOQUINOL	HUMAN PRESCRIPTION DRUG LABEL	2	72056-040	CREAM	10 mg	TOPICAL	Unapproved drug other	17 sections
HYDROCORTISONE 2.5% / IODOQUINOL 1% / KETOCONAZOLE 2%	HUMAN PRESCRIPTION DRUG LABEL	3	72934-2111	CREAM	1 g	TOPICAL	unapproved drug other	4 sections